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Cell No. : Cell Name
RCB1152 : Sawano  update : 2021/02/26
CommentHuman cell line derived from endometrial adenocarcinoma of uterus. Resistant to cisplatin.
Comment from the depositor
Terms and conditionsA prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
Remarks
approver's address
×
English
Address
University of Tsukuba

1-1-1, Tenno-dai, Tsukuba, Ibaraki, 305-8577, Japan
Dr.Satoh, Toyomi
Fax. +81-29-853-3072
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Satoh, Toyomi
Originator Satoh, Toyomi
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 61 years
Tissue uterus
Disease name endometrial adenocarcinoma
Metastastatic ability Yes
Classification cancer
Year of origin 1992
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 15% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 41-92(50) : /44(3),45(9),46(7),47(10),48(11)/
Reference information Reference 1
User's Publication 17


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Reference
1977  Satoh T, Nishida M, Miyazaki Y, Sugita M, Arai Y, Oki A, Kono K, Tsunoda H, Kasahara K, Kubo T  [Establishment of a cisplatin-resistant new human endometrial adenocarcinoma cell line, Sawano cells]  Hum Cell  1995  8:67-72  PubMed ID: 8555123

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User's Publication
11947  Konno T, Kohno T, Kikuchi S, Shimada H, Satohisa S, Saito T, Kondoh M, Kojima T.  Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1.  Tissue Barriers  2020    PubMed ID: 31782346
13069  Okada T, Konno T, Kohno T, Shimada H, Saito K, Satohisa S, Saito T, Kojima T.  Possibility of Targeting Claudin-2 in Therapy for Human Endometrioid Endometrial Carcinoma.  Reprod Sci  2020    PubMed ID: 32548807
13627  Konno T, Kohno T, Okada T, Shimada H, Satohisa S, Kikuchi S, Saito T, Kojima T.  ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer  Histochem Cell Biol  2020  154(2):197-213.  PubMed ID: 32266459
4346  Hashimoto C, Miki Y, Tanaka S, Takagi K, Fue M, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K.  17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer.  Int J Mol Sci  2018    PubMed ID: 29642629
10060  Shimada H, Abe S, Kohno T, Satohisa S, Konno T, Takahashi S, Hatakeyama T, Arimoto C, Kakuki T, Kaneko Y, Takano KI, Saito T, Kojima T.  Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.  Sci Rep  2017  7:37049  PubMed ID: 28071680
10303  Kohno T, Kikuchi S, Ninomiya T, Kojima T.  The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions.  Ann. N. Y. Acad. Sci.  2017  1397:185-194  PubMed ID: 28493278
10532  Shimada H, Satohisa S, Kohno T, Konno T, Takano KI, Takahashi S, Hatakeyama T, Arimoto C, Saito T, Kojima T.  Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer.  Oncol Lett  2017  14:6776-6782  PubMed ID: 29151917
12976  Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno T, Tsujiwaki M, Saito T, Kojima T.  The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells  Oncotarget  2016  7(19):27735-52  PubMed ID: 27036040
8169  Egawa-Takata T, Endo H, Fujita M, Ueda Y, Miyatake T, Okuyama H, Yoshino K, Kamiura S, Enomoto T, Kimura T, Inoue M.  Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer.  Cancer Sci.  2010  101:2171-8  PubMed ID: 20678156
8749  Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S.  Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction.  Endocr. Relat. Cancer  2008  15:451-63  PubMed ID: 18508998
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424
3101  Matsushima-Nishiu M, Unoki M, Ono K, Tsunoda T, Minaguchi T, Kuramoto H, Nishida M, Satoh T, Tanaka T, Nakamura Y  Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.  Cancer Res  2001  61:3741-9  PubMed ID: 11325847
6166  Unoki M, Nakamura Y.  Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.  Oncogene  2001  20(33):4457-65  PubMed ID: 11494141


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