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Cell No. : Cell Name
RCB1148 : TGBC11TKB  update : 2024/04/12
CommentJapanese gastric cancer, lymph node metastated. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Ohno, T. & Todoroki, T.
Originator Kim, B. & Ohno, Tadao
Year of deposit 1995
Another name NaTo
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 72 years
Tissue stomach, lymph node meta
Classification cancer
Year of origin 1995
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1768
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 5% FBS
Antibiotics Free
Passage method pipetting
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 42-95(50) : 42(5),43(5),44(6),45(11),46(6),47(6)/
STR(human) OK
Reference information Reference 0
User's Publication 13

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User's Publication
20664  Han Y, Dong Q, Liu T, Chen X, Yu C, Zhang Y.  The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.  Biochem Biophys Res Commun  2022  610:1-7  PubMed ID: 35461070   DOI: 10.1016/j.bbrc.2022.04.029
16768  J V, Mishra D, Meher D, Dash S, Besra K, Pattnaik N, Singh SP, Dixit M.  Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis  J Hum Genet  2021  66(10):947-956  PubMed ID: 33727629   DOI: 10.1038/s10038-021-00917-x
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826   DOI: 10.1038/s41586-019-1103-9
3734  Cirmi S, Maugeri A, Ferlazzo N, Gangemi S, Calapai G, Schumacher U, Navarra M.  Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies.  Front Pharmacol  2017  8:420  PubMed ID: 28713272   DOI: 10.3389/fphar.2017.00420
14266  Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD.  Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma  Proc Natl Acad Sci U S A  2017  114(43):11404-11409  PubMed ID: 29073064   DOI: 10.1073/pnas.1706617114
9928  Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766   DOI: 10.1073/pnas.1608585113
3733  Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S.  Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer.  Oncotarget  2016  7(41):67251-67265  PubMed ID: 27572307   DOI: 10.18632/oncotarget.11625
5812  Hirashita Y et al  Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells.  Cancer Sci  2016  107(12):1919-1928  PubMed ID: 27699948   DOI: 10.1111/cas.13094
3719  van Haaften G et al  Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.  Nat Genet  2009  41(5):521-3  PubMed ID: 19330029   DOI: 10.1038/ng.349
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
6139  Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y.  IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  Int J Cancer  2008  122(5):1040-6  PubMed ID: 17957782   DOI: 10.1002/ijc.23181
1906  Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y.  Alterations and hypermethylation of the p14(ARF) gene in gastric cancer  Int J Cancer  2000  87(5):654-8  PubMed ID: 10925358   DOI: 10.1002/1097-0215(20000901)87:5<654::aid-ijc6>;2-p
2747  Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M, Takemura Y, Ju-ichi M, Ito C, Furukawa H.  The antiproliferative effect of acridone alkaloids on several cancer cell lines  J Nat Prod  1999  62(4):587-9  PubMed ID: 10217715   DOI: 10.1021/np980504z

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