CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1130 : TGBC2TKB]

3716 Onuki K1, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J. Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol 2014 49(4):702-14 PubMed ID: 23588887 DOI: 10.1007/s00535-013-0813-2

2323 Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK. EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus Int J Cancer 2011 129(5):1244-53 PubMed ID: 21710497 DOI: 10.1002/ijc.25758

3708 Ishige K, Shoda J, Kawamoto T, Matsuda S, Ueda T, Hyodo I, Ohkohchi N, Puri RK, Kawakami K. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Int J Cancer 2008 123(12):2915-22 PubMed ID: 18798553 DOI: 10.1002/ijc.23865

2317 Hori H, Ajiki T, Mita Y, Horiuchi H, Hirata K, Matsumoto T, Morimoto H, Fujita T, Ku Y, Kuroda Y. Frequent activation of mitogen-activated protein kinase relative to Akt in extrahepatic biliary tract cancer J Gastroenterol 2007 42(7):567-72 PubMed ID: 17653653 DOI: 10.1007/s00535-007-2055-7

2324 Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK. E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers Clin Cancer Res 2007 13(10):3043-50 PubMed ID: 17505007 DOI: 10.1158/1078-0432.CCR-06-2103

2673 Ghosh, Mila, Koike, Naoto, Yanagimoto, Go, Tsunoda, Shin-Ichi, Kaul, Sunil, Hirano, Takashi, Emura, Fabian, Kashiwagi, Hironobu, Kawamoto, Toru, Ohkohchi, Nobuhiro, Saijo, Kaoru, Ohno, Tadao, Miwa, Masanao, Todoroki, Takeshi Establishment and characterization of unique human gallbladder cancer cell lines. Int J Oncol 2004 24:1189-96 PubMed ID: 15067341

3707 Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, Tanaka N, Matsuo K, Yamada Y, Kohno K, Irimura T. Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. Clin Cancer Res 2004 10(6):2090-9 PubMed ID: 15041730 DOI: 10.1158/1078-0432.ccr-1024-03

2322 Shoda J, Ueda T, Kawamoto T, Todoroki T, Asano T, Sugimoto Y, Ichikawa A, Maruyama T, Nimura Y, Tanaka N. Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis Clin Gastroenterol Hepatol 2003 1(4):285-96 PubMed ID: 15017670

3697 Takada M, Ku Y, Habara K, Ajiki T, Suzuki Y, Kuroda Y. Inhibitory effect of epigallocatechin-3-gallate on growth and invasion in human biliary tract carcinoma cells. World J Surg 2002 26(6):683-6 PubMed ID: 12053219 DOI: 10.1007/s00268-001-0290-2

2237 Moon,Y., Dahlberg,W. K., Yu,Y., Ohno,T. Todoroki,T., and Little,J. B. Radiosensitivity of human biliary tract cancer cell lines in vitro Int J Oncol 1997 10:545-551 PubMed ID: 21533411 DOI: 10.3892/ijo.10.3.545

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21193 Na L, Masuda S, Nagao S, Morisaki S, Iwamoto N, Sakanashi K, Onishi H. C4orf47 Contributes to the Induction of Stem-like Properties in Gallbladder Cancer Under Hypoxia. Anticancer Res 2023 43(5):1925-1932 PubMed ID: 37097647 DOI: 10.21873/anticanres.16352

20194 Ueta E, Tsutsumi K, Kato H, Matsushita H, Shiraha H, Fujii M, Matsumoto K, Horiguchi S, Okada H. Extracellular vesicle-shuttled miRNAs as a diagnostic and prognostic biomarker and their potential roles in gallbladder cancer patients. Sci Rep 2021 11(1):12298 PubMed ID: 34112884 DOI: 10.1038/s41598-021-91804-0

16869 Ichimiya S, Onishi H, Nagao S, Koga S, Sakihama K, Nakayama K, Fujimura A, Oyama Y, Imaizumi A, Oda Y, Nakamura M. GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer Oncol Rep 2021 45(3):997-1010 PubMed ID: 33650666 DOI: 10.3892/or.2021.7947

12106 García P, Rosa L, Vargas S, Weber H, Espinoza JA, Suárez F, Romero-Calvo I, Elgueta N, Rivera V, Nervi B, Obreque J, Leal P, Viñuela E, Aguayo G, Muñiz S, Sagredo A, Roa JC, Bizama C. Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer. Cancers (Basel) 2020 PubMed ID: 32218280 DOI: 10.3390/cancers12040778

12131 García P, Bizama C, Rosa L, Espinoza JA, Weber H, Cerda-Infante J, Sánchez M, Montecinos VP, Lorenzo-Bermejo J, Boekstegers F, Dávila-López M, Alfaro F, Leiva-Acevedo C, Parra Z, Romero D, Kato S, Leal P, Lagos M, Roa JC. Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor. Biol. Res. 2020 PubMed ID: 32293552 DOI: 10.1186/s40659-020-00282-7

13185 Pandey A, Stawiski EW, Durinck S, Gowda H, Goldstein LD, Barbhuiya MA, Schröder MS, Sreenivasamurthy SK, Kim SW, Phalke S, Suryamohan K, Lee K, Chakraborty P, Kode V, Shi X, Chatterjee A, Datta K, Khan AA, Subbannayya T, Wang J, Chaudhuri S, Gupta S, Shrivastav BR, Jaiswal BS, Poojary SS, Bhunia S, Garcia P, Bizama C, Rosa L, Kwon W, Kim H, Han Y, Yadav TD, Ramprasad VL, Chaudhuri A, Modrusan Z, Roa JC, Tiwari PK, Jang JY, Seshagiri S. Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. Nat Commun 2020 PubMed ID: 32839463 DOI: 10.1038/s41467-020-17880-4

20122 Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R. Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers. Front Immunol 2020 11:630139 PubMed ID: 33692777 DOI: 10.3389/fimmu.2020.630139

11395 Subbannayya T, Leal-Rojas P, Zhavoronkov A, Ozerov IV, Korzinkin M, Babu N, Radhakrishnan A, Chavan S, Raja R, Pinto SM, Patil AH, Barbhuiya MA, Kumar P, Guerrero-Preston R, Navani S, Tiwari PK, Kumar RV, Prasad TSK, Roa JC, Pandey A, Sidransky D, Gowda H, Izumchenko E, Chatterjee A. PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40). J Cell Commun Signal 2019 PubMed ID: 30666556 DOI: 10.1007/s12079-018-00503-5

3724 Zhou F, Zhang Y, Sun J, Yang X. Characteristics of a novel cell line ZJU-0430 established from human gallbladder carcinoma. Cancer Cell Int 2019 19:190 PubMed ID: 31367188 DOI: 10.1186/s12935-019-0911-1

3726 Kirti Gondkar, Krishna Patel, Geeta V. Patil Okaly, Bipin Nair, Akhilesh Pandey, Harsha Gowda and Prashant Kumar Dickkopf Homolog 3 (DKK3) Acts as a Potential Tumor Suppressor in Gallbladder Cancer Front Oncol 2019 9:1121 PubMed ID: 31737564 DOI: 10.3389/fonc.2019.01121

3738 Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N. Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate. Cancer Chemother Pharmacol. 2019 83(4):659-671 PubMed ID: 30659304 DOI: 10.1007/s00280-019-03768-8

3730 Gamo K, Okuzono Y, Yabuki M, Ochi T, Sugimura K, Sato Y, Sagara M, Hayashi H, Ishimura Y, Nishimoto Y, Murakawa Y, Shiokawa Z, Gotoh M, Miyazaki T, Ebisuno Y. Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease. Inflamm Bowel Dis 2018 24(6):1251-1265 PubMed ID: 29669006 DOI: 10.1093/ibd/izy079

10170 Weber H, Valbuena JR, Barbhuiya MA, Stein S, Kunkel H, García P, Bizama C, Riquelme I, Espinoza JA, Kurtz SE, Tyner JW, Calderon JF, Corvalán AH, Grez M, Pandey A, Leal-Rojas P, Roa JC. Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer. Oncotarget 2017 8:26169-26184 PubMed ID: 28412732 DOI: 10.18632/oncotarget.15410

10222 Yang L, Huang S, Ma H, Wu X, Feng F. MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer. Tumour Biol. 2017 39:1010428317692249 PubMed ID: 28347246 DOI: 10.1177/1010428317692249

3690 uchegger K, Silva R2, López J1, Ili C1, Araya JC3, Leal P2, Brebi P1, Riquelme I4, Roa JC5. The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer. Pathol Res Pract. 2017 213(5):476-482 PubMed ID: 28285962 DOI: 10.1016/j.prp.2017.01.025

3723 Liu ZY, Xu GL, Tao HH, Yang YQ, Fan YZ. Establishment and characterization of a novel highly aggressive gallbladder cancer cell line, TJ-GBC2. Cancer Cell Int 2017 17:20 PubMed ID: 28194091 DOI: 10.1186/s12935-017-0388-8

3725 Kawamoto M, Onishi H, Ozono K, Yamasaki A, Imaizumi A, Kamakura S, Nakano K, Oda Y, Sumimoto H, Nakamura M Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer. Oncotarget 2017 8(22):36211-36224 PubMed ID: 28423707 DOI: 10.18632/oncotarget.16063

3727 Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines. Mol Oncol 2017 11(9):1130-1142 PubMed ID: 28544747 DOI: 10.1002/1878-0261.12078

3728 Makoto Kawamoto, Hideya Onishi, Keigo Ozono, Akio Yamasaki, Akira Imaizumi and Masafumi Nakamura TrkB-mediated signaling contributes to malignant phenotypes of gallbladder cancer Cancer Research 2017 1-5 DOI: 10.1158/1538-7445.AM2017-5794

3731 Mittal B, Yadav S. Targeting the hedgehog pathway for gallbladder cancer therapy? Chin Clin Oncol 2016 5(1):2 PubMed ID: 26932426 DOI: 10.3978/j.issn.2304-3865.2015.12.03

3691 Weber H, Leal P, Stein S, Kunkel H, García P, Bizama C, Espinoza JA, Riquelme I, Nervi B, Araya JC, Grez M, Roa JC. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice. Oncotarget 2015 6(31):31877-88 PubMed ID: 26397134 DOI: 10.18632/oncotarget.5047

3709 Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J. Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab. J Gastroenterol 2015 50(4):467-79 PubMed ID: 25112701 DOI: 10.1007/s00535-014-0984-5

3729 Subbannayya T et al Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. BMC Cancer 2015 15:843 PubMed ID: 26530123 DOI: 10.1186/s12885-015-1855-z

3732 Zhang P, Guo Z, Wu Y, Hu R, Du J, He X, Jiao X, Zhu X. Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. PLoS One 2015 10(8):e0136193 PubMed ID: 26287365 DOI: 10.1371/journal.pone.0136193

17464 Shi Z, Huang Q, Chen J, Yu P, Wang X, Qiu H, Chen Y, Dong Y. Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder Am J Transl Res 2015 7(10):2015-25 PubMed ID: 26692945

13739 Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC. miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer Int J Clin Exp Pathol 2014 7(5):1849-67 PubMed ID: 24966896

14930 Takahashi N, Aoyama F, Hiyoshi M, Kataoka H, Sawaguchi A. Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater Int J Oncol 2014 44(4):1139-45 PubMed ID: 24481592 DOI: 10.3892/ijo.2014.2282

3693 Leal P, Garcia P, Sandoval A, Buchegger K, Weber H, Tapia O, Roa JC. AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines. Onco Targets Ther 2013 6:1373-84 PubMed ID: 24124380 DOI: 10.2147/OTT.S46897

3694 Yang S, Lee KT, Lee JY, Lee JK, Lee KH, Rhee JC. Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. Tumour Biol 2013 34(5):2731-9 PubMed ID: 23653380 DOI: 10.1007/s13277-013-0825-9

3714 Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y. Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World J Gastroenterol 2013 19(11):1718-27 PubMed ID: 23555160 DOI: 10.3748/wjg.v19.i11.1718

19025 Sekine S, Shimada Y, Nagata T, Moriyama M, Omura T, Yoshioka I, Hori R, Matsui K, Sawada S, Okumura T, Yoshida T, Tsukada K. Establishment and characterization of a new human gallbladder carcinoma cell line Anticancer Res 2012 32(8):3211-8 PubMed ID: 22843894

3722 Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci 2012 103(2):252-61 PubMed ID: 22044563 DOI: 10.1111/j.1349-7006.2011.02138.x

6101 Ono H, Hiraoka N, Lee YS, Woo SM, Lee WJ, Choi IJ, Saito A, Yanagihara K, Kanai Y, Ohnami S, Chiwaki F, Sasaki H, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes Chromosomes Cancer. 2012 51(1):30-41 PubMed ID: 21936014 DOI: 10.1002/gcc.20928

6319 Wu LC, Chen LT, Tsai YJ, Lin CM, Lin CY, Tian YF, Sheu MJ, Uen YH, Shiue YL, Wang YH, Yang SJ, Wu WR, Li SH, Iwamuro M, Kobayasshi N, Huang HY, Li CF. Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator. J Clin Pathol 2012 65(4):309-14 PubMed ID: 22267983 DOI: 10.1136/jclinpath-2011-200489

16078 Yang MH, Lee KT, Yang S, Lee JK, Lee KH, Moon IH, Rhee JC. Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-κB J Cancer Res Clin Oncol 2012 138(10):1743-51 PubMed ID: 22699931 DOI: 10.1007/s00432-012-1254-7

7862 Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M. Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2011 18:700-11 PubMed ID: 21451941 DOI: 10.1007/s00534-011-0376-7

19029 Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y. LRRN4 and UPK3B are markers of primary mesothelial cells PLoS One 2011 6(10):e25391 PubMed ID: 21984916 DOI: 10.1371/journal.pone.0025391

3711 Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H. Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells. Cancer Sci 2011 102(2):407-13 PubMed ID: 21166957 DOI: 10.1111/j.1349-7006.2010.01808.x

8464 Yamaguchi J, Sasaki M, Sato Y, Itatsu K, Harada K, Zen Y, Ikeda H, Nimura Y, Nagino M, Nakanuma Y. Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma. Cancer Sci. 2010 101:355-62 PubMed ID: 19860841 DOI: 10.1111/j.1349-7006.2009.01387.x

8548 Yamaguchi J, Sasaki M, Harada K, Zen Y, Sato Y, Ikeda H, Itatsu K, Yokoyama Y, Ando H, Ohta T, Kubota A, Shimizu K, Nimura Y, Nagino M, Nakanuma Y. Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin. Lab. Invest. 2009 89:1018-31 PubMed ID: 19564843 DOI: 10.1038/labinvest.2009.65

3705 Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y. Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer. World J Gastroenterol 2009 15(31):3865-73 PubMed ID: 19701966 DOI: 10.3748/wjg.15.3865

18693 Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer Gastroenterology 2008 135(4):1358-1368 PubMed ID: 18692501 DOI: 10.1053/j.gastro.2008.06.082

3712 Maehata T, Taniguchi H, Yamamoto H, Nosho K, Adachi Y, Miyamoto N, Miyamoto C, Akutsu N, Yamaoka S, Itoh F. Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. World J Gastroenterol 2008 14(17):2702-14 PubMed ID: 18461655 DOI: 10.3748/wjg.14.2702

19308 Taniguchi H, Yamamoto H, Akutsu N, Nosho K, Adachi Y, Imai K, Shinomura Y. Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer J Pathol 2007 213(2):131-9 PubMed ID: 17724792 DOI: 10.1002/path.2216

19219 Sato K, Kitajima Y, Koga Y, Miyazaki K. The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells Anticancer Res 2005 25(6B):4021-8 PubMed ID: 16309194

3701 DINGAng TONGSaixiong SUOTao Relations of hTERT and β-Catenin Expression with Cell Growth and Invasion in Gallbladder Cell Line Clinical Medical Journal of China 2005

3713 Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 2005 24(53):7946-52 PubMed ID: 16007117 DOI: 10.1038/sj.onc.1208910

13744 Sato K, Kitajima Y, Kohya N, Miyoshi A, Koga Y, Miyazaki K. Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest Int J Oncol 2005 26(6):1653-61 PubMed ID: 15870882

3717 Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene 2004 23(13):2401-7 PubMed ID: 14743205 DOI: 10.1038/sj.onc.1207395

3699 Nakano K, Todo T, Chijiiwa K, Tanaka M. Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters. Mol Ther 2001 3(4):431-7. PubMed ID: 11319903 DOI: 10.1006/mthe.2001.0303