CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1129 : TGBC1TKB]

3718 Shoda J1, Matsuda A2, Shida T3, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H. Wisteria floribunda agglutinin-sialylated mucin core polypeptide 1 is a sensitive biomarker for biliary tract carcinoma and intrahepatic cholangiocarcinoma: a multicenter study. J Gastroenterol 2017 52(2):218-228 PubMed ID: 27358229 DOI: 10.1007/s00535-016-1230-0

3704 Seto 1, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Int J Hepatol 2014 584650 PubMed ID: 24868471 DOI: 10.1155/2014/584650

3716 Onuki K1, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J. Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol 2014 49(4):702-14 PubMed ID: 23588887 DOI: 10.1007/s00535-013-0813-2

2323 Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK. EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus Int J Cancer 2011 129(5):1244-53 PubMed ID: 21710497 DOI: 10.1002/ijc.25758

3708 Ishige K, Shoda J, Kawamoto T, Matsuda S, Ueda T, Hyodo I, Ohkohchi N, Puri RK, Kawakami K. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Int J Cancer 2008 123(12):2915-22 PubMed ID: 18798553 DOI: 10.1002/ijc.23865

2324 Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK. E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers Clin Cancer Res 2007 13(10):3043-50 PubMed ID: 17505007 DOI: 10.1158/1078-0432.CCR-06-2103

2321 Hirata K, Ajiki T, Okazaki T, Horiuchi H, Fujita T, Kuroda Y. Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis Oncology 2006 71(1-2):102-10 PubMed ID: 17341890 DOI: 10.1159/000100478

2673 Ghosh, Mila, Koike, Naoto, Yanagimoto, Go, Tsunoda, Shin-Ichi, Kaul, Sunil, Hirano, Takashi, Emura, Fabian, Kashiwagi, Hironobu, Kawamoto, Toru, Ohkohchi, Nobuhiro, Saijo, Kaoru, Ohno, Tadao, Miwa, Masanao, Todoroki, Takeshi Establishment and characterization of unique human gallbladder cancer cell lines. Int J Oncol 2004 24:1189-96 PubMed ID: 15067341

3707 Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, Tanaka N, Matsuo K, Yamada Y, Kohno K, Irimura T. Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. Clin Cancer Res 2004 10(6):2090-9 PubMed ID: 15041730 DOI: 10.1158/1078-0432.ccr-1024-03

2322 Shoda J, Ueda T, Kawamoto T, Todoroki T, Asano T, Sugimoto Y, Ichikawa A, Maruyama T, Nimura Y, Tanaka N. Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis Clin Gastroenterol Hepatol 2003 1(4):285-96 PubMed ID: 15017670

2319 Koike N, Todoroki T, Kawamoto T, Yoshida S, Kashiwagi H, Fukao K, Ohno T, Watanabe T The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics. Int J Oncol 1998 13:1269-74 PubMed ID: 9824643 DOI: 10.3892/ijo.13.6.1269

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23078 Jeeyar V, Besra K, Singh SP, Dixit M. Unveiling the causative role of promoter variant rs113823671 in MMP7 in gallbladder cancer susceptibility. Sci Rep 2025 15(1):27958 PubMed ID: 40745028 DOI: 10.1038/s41598-025-13833-3

22703 Triboulet R, Sadykov K, Harvey DM, Wilson DM, Steinbaugh MJ, Mayo CB, Hawley D, Madanjian A, Fyfe C, Bracken C, Rivera-Rivera I, Ericsson A, Snyder AR, Knutson SK, Stein RL, Gibaja V, Ghosh S, Campbell RM. Targeting the Synthetic Lethal Relationship between FOCAD and TUT7 Represents a Potential Therapeutic Opportunity for TUT4/7 Small-Molecule Inhibitors in Cancer Mol Cancer Ther 2024 23(12):1779-1788 PubMed ID: 39235218 DOI: 10.1158/1535-7163.MCT-24-0176

19816 J V, Palo A, Besra K, Dixit M. Gallbladder cancer-associated genetic variants rs1003349 and rs1004030 regulate MMP14 expression by altering SOX10- and MYB-binding sites Hum Mol Genet 2023 32(14):2357-2372 PubMed ID: 37162337 DOI: 10.1093/hmg/ddad077

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

15892 Khorsandi SE, Dokal AD, Rajeeve V, Britton DJ, Illingworth MS, Heaton N, Cutillas PR. Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets. Cancer Res 2021 81(22):5765-5776 PubMed ID: 34551960 DOI: 10.1158/0008-5472.CAN-21-0955

12106 García P, Rosa L, Vargas S, Weber H, Espinoza JA, Suárez F, Romero-Calvo I, Elgueta N, Rivera V, Nervi B, Obreque J, Leal P, Viñuela E, Aguayo G, Muñiz S, Sagredo A, Roa JC, Bizama C. Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer. Cancers (Basel) 2020 PubMed ID: 32218280 DOI: 10.3390/cancers12040778

12131 García P, Bizama C, Rosa L, Espinoza JA, Weber H, Cerda-Infante J, Sánchez M, Montecinos VP, Lorenzo-Bermejo J, Boekstegers F, Dávila-López M, Alfaro F, Leiva-Acevedo C, Parra Z, Romero D, Kato S, Leal P, Lagos M, Roa JC. Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor. Biol. Res. 2020 PubMed ID: 32293552 DOI: 10.1186/s40659-020-00282-7

20122 Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R. Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers. Front Immunol 2020 11:630139 PubMed ID: 33692777 DOI: 10.3389/fimmu.2020.630139

3721 Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM. Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity. JCI Insight 2019 4(2):e121490. PubMed ID: 30674722 DOI: 10.1172/jci.insight.121490

10170 Weber H, Valbuena JR, Barbhuiya MA, Stein S, Kunkel H, García P, Bizama C, Riquelme I, Espinoza JA, Kurtz SE, Tyner JW, Calderon JF, Corvalán AH, Grez M, Pandey A, Leal-Rojas P, Roa JC. Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer. Oncotarget 2017 8:26169-26184 PubMed ID: 28412732 DOI: 10.18632/oncotarget.15410

10222 Yang L, Huang S, Ma H, Wu X, Feng F. MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer. Tumour Biol. 2017 39:1010428317692249 PubMed ID: 28347246 DOI: 10.1177/1010428317692249

3690 uchegger K, Silva R2, López J1, Ili C1, Araya JC3, Leal P2, Brebi P1, Riquelme I4, Roa JC5. The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer. Pathol Res Pract. 2017 213(5):476-482 PubMed ID: 28285962 DOI: 10.1016/j.prp.2017.01.025

3720 Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N5. Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma. Sci Rep 2017 7(1):244 PubMed ID: 28325920 DOI: 10.1038/s41598-017-00357-8

7134 Mohri D, Ijichi H, Miyabayashi K, Takahashi R, Kudo Y, Sasaki T, Asaoka Y, Tanaka Y, Ikenoue T, Tateishi K, Tada M, Isayama H, Koike K. A potent therapeutics for gallbladder cancer by combinatorial inhibition of the MAPK and mTOR signaling networks. J. Gastroenterol. 2016 51:711-21 PubMed ID: 26614007 DOI: 10.1007/s00535-015-1145-1

3710 Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y, Shoda J, Narimatsu H, Nagino M. Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer. Ann Surg Oncol 2016 23(2):671-7 PubMed ID: 26416714 DOI: 10.1245/s10434-015-4878-4

12665 Cavalloni G, Peraldo-Neia C, Varamo C, Chiorino G, Sassi F, Aglietta M, Leone F. Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma Oncotarget 2016 7(32):52354-52363 PubMed ID: 27429047 DOI: 10.18632/oncotarget.10587

7273 Nakano T, Saiki Y, Kudo C, Hirayama A, Mizuguchi Y, Fujiwara S, Soga T, Sunamura M, Matsumura N, Motoi F, Unno M, Horii A. Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK. Biochem. Biophys. Res. Commun. 2015 464:1084-9 PubMed ID: 26196746 DOI: 10.1016/j.bbrc.2015.07.080

7355 Saeki N, Ono H, Sakamoto H, Yoshida T. Down-regulation of Immune-related Genes by PSCA in Gallbladder Cancer Cells Implanted into Mice. Anticancer Res. 2015 35:2619-25 PubMed ID: 25964537

7466 Saeki N, Ono H, Yanagihara K, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T. rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1. Genes Cells 2015 20:382-91 PubMed ID: 25727947 DOI: 10.1111/gtc.12228

3706 Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1. Anal Chem 2015 87(14):7274-81 PubMed ID: 26091356 DOI: 10.1021/acs.analchem.5b01329

3709 Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J. Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab. J Gastroenterol 2015 50(4):467-79 PubMed ID: 25112701 DOI: 10.1007/s00535-014-0984-5

17464 Shi Z, Huang Q, Chen J, Yu P, Wang X, Qiu H, Chen Y, Dong Y. Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder Am J Transl Res 2015 7(10):2015-25 PubMed ID: 26692945

4891 Peraldo Neia C, Cavalloni G, Balsamo A, Venesio T, Napoli F, Sassi F, Martin V, Frattini M, Aglietta M, Leone F. Screening for the FIG-ROS1 fusion in biliary tract carcinomas by nested PCR. Genes Chromosomes Cancer 2014 53(12):1033-40 PubMed ID: 25231053 DOI: 10.1002/gcc.22212

13739 Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC. miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer Int J Clin Exp Pathol 2014 7(5):1849-67 PubMed ID: 24966896

3693 Leal P, Garcia P, Sandoval A, Buchegger K, Weber H, Tapia O, Roa JC. AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines. Onco Targets Ther 2013 6:1373-84 PubMed ID: 24124380 DOI: 10.2147/OTT.S46897

3694 Yang S, Lee KT, Lee JY, Lee JK, Lee KH, Rhee JC. Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. Tumour Biol 2013 34(5):2731-9 PubMed ID: 23653380 DOI: 10.1007/s13277-013-0825-9

3695 Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K. Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells. J Carcinog 2013 12:4 PubMed ID: 23599686 DOI: 10.4103/1477-3163.109030

3714 Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y. Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World J Gastroenterol 2013 19(11):1718-27 PubMed ID: 23555160 DOI: 10.3748/wjg.v19.i11.1718

3715 Idrees AS, Sugie T, Inoue C, Murata-Hirai K, Okamura H, Morita CT, Minato N, Toi M, Tanaka Y. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci 2013 104(5):536-42 PubMed ID: 23387443 DOI: 10.1111/cas.12124

3722 Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci 2012 103(2):252-61 PubMed ID: 22044563 DOI: 10.1111/j.1349-7006.2011.02138.x

6101 Ono H, Hiraoka N, Lee YS, Woo SM, Lee WJ, Choi IJ, Saito A, Yanagihara K, Kanai Y, Ohnami S, Chiwaki F, Sasaki H, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes Chromosomes Cancer. 2012 51(1):30-41 PubMed ID: 21936014 DOI: 10.1002/gcc.20928

6319 Wu LC, Chen LT, Tsai YJ, Lin CM, Lin CY, Tian YF, Sheu MJ, Uen YH, Shiue YL, Wang YH, Yang SJ, Wu WR, Li SH, Iwamuro M, Kobayasshi N, Huang HY, Li CF. Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator. J Clin Pathol 2012 65(4):309-14 PubMed ID: 22267983 DOI: 10.1136/jclinpath-2011-200489

16078 Yang MH, Lee KT, Yang S, Lee JK, Lee KH, Moon IH, Rhee JC. Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-κB J Cancer Res Clin Oncol 2012 138(10):1743-51 PubMed ID: 22699931 DOI: 10.1007/s00432-012-1254-7

7862 Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M. Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2011 18:700-11 PubMed ID: 21451941 DOI: 10.1007/s00534-011-0376-7

8068 Takeuchi T, Adachi Y, Nagayama T, Furihata M. Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer. Int J Exp Pathol 2011 92:79-86 PubMed ID: 21039987 DOI: 10.1111/j.1365-2613.2010.00740.x

3711 Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H. Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells. Cancer Sci 2011 102(2):407-13 PubMed ID: 21166957 DOI: 10.1111/j.1349-7006.2010.01808.x

3702 Tan FL, Ooi A, Huang D, Wong JC, Qian CN, Chao C, Ooi L, Tan YM, Chung A, Cheow PC, Zhang Z, Petillo D, Yang XJ, Teh BT. p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. Int J Cancer 2010 126(10):2353-61 PubMed ID: 19816939 DOI: 10.1002/ijc.24944

3705 Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y. Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer. World J Gastroenterol 2009 15(31):3865-73 PubMed ID: 19701966 DOI: 10.3748/wjg.15.3865

3719 van Haaften G et al Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009 41(5):521-3 PubMed ID: 19330029 DOI: 10.1038/ng.349

3712 Maehata T, Taniguchi H, Yamamoto H, Nosho K, Adachi Y, Miyamoto N, Miyamoto C, Akutsu N, Yamaoka S, Itoh F. Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. World J Gastroenterol 2008 14(17):2702-14 PubMed ID: 18461655 DOI: 10.3748/wjg.14.2702

19308 Taniguchi H, Yamamoto H, Akutsu N, Nosho K, Adachi Y, Imai K, Shinomura Y. Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer J Pathol 2007 213(2):131-9 PubMed ID: 17724792 DOI: 10.1002/path.2216

3700 Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol 2005 131(5):271-8 PubMed ID: 15645288 DOI: 10.1007/s00432-004-0658-4

3701 DINGAng TONGSaixiong SUOTao Relations of hTERT and β-Catenin Expression with Cell Growth and Invasion in Gallbladder Cell Line Clinical Medical Journal of China 2005

3713 Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene 2005 24(53):7946-52 PubMed ID: 16007117 DOI: 10.1038/sj.onc.1208910

3703 Sanada T, Yokoi S, Arii S, Yasui K, Imoto I, Inazawa J. Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers. Cancer Sci 2004 95(12):969-76 PubMed ID: 15596046 DOI: 10.1111/j.1349-7006.2004.tb03185.x

3717 Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene 2004 23(13):2401-7 PubMed ID: 14743205 DOI: 10.1038/sj.onc.1207395

3696 Hirata K, Takada M, Suzuki Y, Kuroda Y. Expression of receptor for advanced glycation end products (RAGE) in human biliary cancer cells. Hepatogastroenterology 2003 50(53):1205-7 PubMed ID: 14571699

3699 Nakano K, Todo T, Chijiiwa K, Tanaka M. Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters. Mol Ther 2001 3(4):431-7. PubMed ID: 11319903 DOI: 10.1006/mthe.2001.0303