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Cell No. : Cell Name
RCB1129 : TGBC1TKB  update : 2022/09/16
CommentJapanese gallbadder carcinoma metastated to lymph node from the same patient of TGBC2TKB. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Todoroki, T. & Ohno, T.
Originator Todoroki, T. & Ohno, T. & Kim, B.
Year of deposit 1994
Another name TGBC-1, Na
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Tissue gallbladder, lymph node meta
Metastatic ability Yes
Metastatic tissue lymph node
Classification cancer
Year of origin 1994
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1769
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 5% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 58-65(65) : 58(5),59(8),60(15),61(16),62(8),63(4)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 46


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Reference
3718  Shoda J1, Matsuda A2, Shida T3, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.  Wisteria floribunda agglutinin-sialylated mucin core polypeptide 1 is a sensitive biomarker for biliary tract carcinoma and intrahepatic cholangiocarcinoma: a multicenter study.  J Gastroenterol  2017  52(2):218-228  PubMed ID: 27358229   DOI: 10.1007/s00535-016-1230-0
3704  Seto 1, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K.  Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.  Int J Hepatol  2014  584650  PubMed ID: 24868471   DOI: 10.1155/2014/584650
3716  Onuki K1, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.  Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.  J Gastroenterol  2014  49(4):702-14  PubMed ID: 23588887   DOI: 10.1007/s00535-013-0813-2
3708  Ishige K, Shoda J, Kawamoto T, Matsuda S, Ueda T, Hyodo I, Ohkohchi N, Puri RK, Kawakami K.  Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma.  Int J Cancer  2008  123(12):2915-22  PubMed ID: 18798553   DOI: 10.1002/ijc.23865
3707  Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, Tanaka N, Matsuo K, Yamada Y, Kohno K, Irimura T.  Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.  Clin Cancer Res  2004  10(6):2090-9  PubMed ID: 15041730   DOI: 10.1158/1078-0432.ccr-1024-03

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User's Publication
19816  J V, Palo A, Besra K, Dixit M.  Gallbladder cancer-associated genetic variants rs1003349 and rs1004030 regulate MMP14 expression by altering SOX10- and MYB-binding sites  Hum Mol Genet  2023  32(14):2357-2372  PubMed ID: 37162337   DOI: 10.1093/hmg/ddad077
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
15892  Khorsandi SE, Dokal AD, Rajeeve V, Britton DJ, Illingworth MS, Heaton N, Cutillas PR.  Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets.  Cancer Res  2021  81(22):5765-5776  PubMed ID: 34551960   DOI: 10.1158/0008-5472.CAN-21-0955
12106  García P, Rosa L, Vargas S, Weber H, Espinoza JA, Suárez F, Romero-Calvo I, Elgueta N, Rivera V, Nervi B, Obreque J, Leal P, Viñuela E, Aguayo G, Muñiz S, Sagredo A, Roa JC, Bizama C.  Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer.  Cancers (Basel)  2020    PubMed ID: 32218280   DOI: 10.3390/cancers12040778
12131  García P, Bizama C, Rosa L, Espinoza JA, Weber H, Cerda-Infante J, Sánchez M, Montecinos VP, Lorenzo-Bermejo J, Boekstegers F, Dávila-López M, Alfaro F, Leiva-Acevedo C, Parra Z, Romero D, Kato S, Leal P, Lagos M, Roa JC.  Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.  Biol. Res.  2020    PubMed ID: 32293552   DOI: 10.1186/s40659-020-00282-7
20122  Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R.  Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.  Front Immunol  2020  11:630139  PubMed ID: 33692777   DOI: 10.3389/fimmu.2020.630139
3721  Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM.  Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity.  JCI Insight  2019  4(2):e121490.  PubMed ID: 30674722   DOI: 10.1172/jci.insight.121490
3724  Zhou F, Zhang Y, Sun J, Yang X.  Characteristics of a novel cell line ZJU-0430 established from human gallbladder carcinoma.  Cancer Cell Int  2019  19:190  PubMed ID: 31367188   DOI: 10.1186/s12935-019-0911-1
10170  Weber H, Valbuena JR, Barbhuiya MA, Stein S, Kunkel H, García P, Bizama C, Riquelme I, Espinoza JA, Kurtz SE, Tyner JW, Calderon JF, Corvalán AH, Grez M, Pandey A, Leal-Rojas P, Roa JC.  Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.  Oncotarget  2017  8:26169-26184  PubMed ID: 28412732   DOI: 10.18632/oncotarget.15410
10222  Yang L, Huang S, Ma H, Wu X, Feng F.  MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer.  Tumour Biol.  2017  39:1010428317692249  PubMed ID: 28347246   DOI: 10.1177/1010428317692249
3690  uchegger K, Silva R2, López J1, Ili C1, Araya JC3, Leal P2, Brebi P1, Riquelme I4, Roa JC5.  The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer.  Pathol Res Pract.  2017  213(5):476-482  PubMed ID: 28285962   DOI: 10.1016/j.prp.2017.01.025
3720  Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N5.  Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma.  Sci Rep  2017  7(1):244  PubMed ID: 28325920   DOI: 10.1038/s41598-017-00357-8
3723  Liu ZY, Xu GL, Tao HH, Yang YQ, Fan YZ.  Establishment and characterization of a novel highly aggressive gallbladder cancer cell line, TJ-GBC2.  Cancer Cell Int  2017  17:20  PubMed ID: 28194091   DOI: 10.1186/s12935-017-0388-8
7134  Mohri D, Ijichi H, Miyabayashi K, Takahashi R, Kudo Y, Sasaki T, Asaoka Y, Tanaka Y, Ikenoue T, Tateishi K, Tada M, Isayama H, Koike K.  A potent therapeutics for gallbladder cancer by combinatorial inhibition of the MAPK and mTOR signaling networks.  J. Gastroenterol.  2016  51:711-21  PubMed ID: 26614007   DOI: 10.1007/s00535-015-1145-1
3710  Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y, Shoda J, Narimatsu H, Nagino M.  Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer.  Ann Surg Oncol  2016  23(2):671-7  PubMed ID: 26416714   DOI: 10.1245/s10434-015-4878-4
12665  Cavalloni G, Peraldo-Neia C, Varamo C, Chiorino G, Sassi F, Aglietta M, Leone F.  Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma  Oncotarget  2016  7(32):52354-52363  PubMed ID: 27429047   DOI: 10.18632/oncotarget.10587
7273  Nakano T, Saiki Y, Kudo C, Hirayama A, Mizuguchi Y, Fujiwara S, Soga T, Sunamura M, Matsumura N, Motoi F, Unno M, Horii A.  Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.  Biochem. Biophys. Res. Commun.  2015  464:1084-9  PubMed ID: 26196746   DOI: 10.1016/j.bbrc.2015.07.080
7355  Saeki N, Ono H, Sakamoto H, Yoshida T.  Down-regulation of Immune-related Genes by PSCA in Gallbladder Cancer Cells Implanted into Mice.  Anticancer Res.  2015  35:2619-25  PubMed ID: 25964537  
7466  Saeki N, Ono H, Yanagihara K, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T.  rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1.  Genes Cells  2015  20:382-91  PubMed ID: 25727947   DOI: 10.1111/gtc.12228
3706  Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H.  Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1.  Anal Chem  2015  87(14):7274-81  PubMed ID: 26091356   DOI: 10.1021/acs.analchem.5b01329
3709  Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.  Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.  J Gastroenterol  2015  50(4):467-79  PubMed ID: 25112701   DOI: 10.1007/s00535-014-0984-5
17464  Shi Z, Huang Q, Chen J, Yu P, Wang X, Qiu H, Chen Y, Dong Y.  Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder  Am J Transl Res  2015  7(10):2015-25  PubMed ID: 26692945  
4891  Peraldo Neia C, Cavalloni G, Balsamo A, Venesio T, Napoli F, Sassi F, Martin V, Frattini M, Aglietta M, Leone F.  Screening for the FIG-ROS1 fusion in biliary tract carcinomas by nested PCR.  Genes Chromosomes Cancer  2014  53(12):1033-40  PubMed ID: 25231053   DOI: 10.1002/gcc.22212
13739  Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC.  miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer  Int J Clin Exp Pathol  2014  7(5):1849-67  PubMed ID: 24966896  
3694  Yang S, Lee KT, Lee JY, Lee JK, Lee KH, Rhee JC.  Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells.  Tumour Biol  2013  34(5):2731-9  PubMed ID: 23653380   DOI: 10.1007/s13277-013-0825-9
3695  Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K.  Missense allele of a single nucleotide polymorphism rs2294008 attenuated antitumor effects of prostate stem cell antigen in gallbladder cancer cells.  J Carcinog  2013  12:4  PubMed ID: 23599686   DOI: 10.4103/1477-3163.109030
3714  Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y.  Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.  World J Gastroenterol  2013  19(11):1718-27  PubMed ID: 23555160   DOI: 10.3748/wjg.v19.i11.1718
3715  Idrees AS, Sugie T, Inoue C, Murata-Hirai K, Okamura H, Morita CT, Minato N, Toi M, Tanaka Y.  Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.  Cancer Sci  2013  104(5):536-42  PubMed ID: 23387443   DOI: 10.1111/cas.12124
3722  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.  Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.  Cancer Sci  2012  103(2):252-61  PubMed ID: 22044563   DOI: 10.1111/j.1349-7006.2011.02138.x
6101  Ono H, Hiraoka N, Lee YS, Woo SM, Lee WJ, Choi IJ, Saito A, Yanagihara K, Kanai Y, Ohnami S, Chiwaki F, Sasaki H, Sakamoto H, Yoshida T, Saeki N.  Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis.  Genes Chromosomes Cancer.  2012  51(1):30-41  PubMed ID: 21936014   DOI: 10.1002/gcc.20928
6319  Wu LC, Chen LT, Tsai YJ, Lin CM, Lin CY, Tian YF, Sheu MJ, Uen YH, Shiue YL, Wang YH, Yang SJ, Wu WR, Li SH, Iwamuro M, Kobayasshi N, Huang HY, Li CF.  Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator.  J Clin Pathol  2012  65(4):309-14  PubMed ID: 22267983   DOI: 10.1136/jclinpath-2011-200489
16078  Yang MH, Lee KT, Yang S, Lee JK, Lee KH, Moon IH, Rhee JC.  Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-κB  J Cancer Res Clin Oncol   2012  138(10):1743-51  PubMed ID: 22699931   DOI: 10.1007/s00432-012-1254-7
7862  Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M.  Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.  J Hepatobiliary Pancreat Sci  2011  18:700-11  PubMed ID: 21451941   DOI: 10.1007/s00534-011-0376-7
8068  Takeuchi T, Adachi Y, Nagayama T, Furihata M.  Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.  Int J Exp Pathol  2011  92:79-86  PubMed ID: 21039987   DOI: 10.1111/j.1365-2613.2010.00740.x
3711  Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H.  Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells.  Cancer Sci  2011  102(2):407-13  PubMed ID: 21166957   DOI: 10.1111/j.1349-7006.2010.01808.x
3702  Tan FL, Ooi A, Huang D, Wong JC, Qian CN, Chao C, Ooi L, Tan YM, Chung A, Cheow PC, Zhang Z, Petillo D, Yang XJ, Teh BT.  p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion.  Int J Cancer  2010  126(10):2353-61  PubMed ID: 19816939   DOI: 10.1002/ijc.24944
3705  Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.  Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.  World J Gastroenterol  2009  15(31):3865-73  PubMed ID: 19701966   DOI: 10.3748/wjg.15.3865
3719  van Haaften G et al  Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.  Nat Genet  2009  41(5):521-3  PubMed ID: 19330029   DOI: 10.1038/ng.349
3712  Maehata T, Taniguchi H, Yamamoto H, Nosho K, Adachi Y, Miyamoto N, Miyamoto C, Akutsu N, Yamaoka S, Itoh F.  Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer.  World J Gastroenterol  2008  14(17):2702-14  PubMed ID: 18461655   DOI: 10.3748/wjg.14.2702
3700  Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y.  Expression of homeodomain protein CDX2 in gallbladder carcinomas.  J Cancer Res Clin Oncol  2005  131(5):271-8  PubMed ID: 15645288   DOI: 10.1007/s00432-004-0658-4
3701  DINGAng TONGSaixiong SUOTao  Relations of hTERT and β-Catenin Expression with Cell Growth and Invasion in Gallbladder Cell Line  Clinical Medical Journal of China  2005     
3713  Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y.  Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.  Oncogene  2005  24(53):7946-52  PubMed ID: 16007117   DOI: 10.1038/sj.onc.1208910
3703  Sanada T, Yokoi S, Arii S, Yasui K, Imoto I, Inazawa J.  Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers.  Cancer Sci  2004  95(12):969-76  PubMed ID: 15596046   DOI: 10.1111/j.1349-7006.2004.tb03185.x
3717  Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T.  Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines.  Oncogene  2004  23(13):2401-7  PubMed ID: 14743205   DOI: 10.1038/sj.onc.1207395
3696  Hirata K, Takada M, Suzuki Y, Kuroda Y.  Expression of receptor for advanced glycation end products (RAGE) in human biliary cancer cells.  Hepatogastroenterology  2003  50(53):1205-7  PubMed ID: 14571699  
3699  Nakano K, Todo T, Chijiiwa K, Tanaka M.  Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters.  Mol Ther  2001  3(4):431-7.  PubMed ID: 11319903   DOI: 10.1006/mthe.2001.0303



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