Cell No. : Cell Name
RCB1015 : T3M-1 Clone2
update : 2024/11/12
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| Comment | G-CSF producing oral squamous cell carcinoma, the same patient as T3M-1 Cl-10 and CJM. |
| Comment from the depositor | |
| Terms and conditions | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| Remarks | |
| Order Form |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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Basic information
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Depositor |
Okabe, Tetsuro
|
| Originator |
Okabe, Tetsuro
|
| Year of deposit |
1994
|
| Another name |
CJM-25 C5
|
| Original cell |
T3M-1
|
| Animal |
_human
< Mammals
|
| Genus |
Homo
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| Species |
sapiens
|
| Race |
Japanese
|
| Gender |
Male
|
| Age at sampling |
33 years
|
| Tissue |
oral cavity
|
| Disease name |
squamous cell carcinoma
|
| Metastatic ability |
Yes
|
| Metastatic tissue |
the thoracic cavity
|
| Classification |
cancer
|
| Year of origin |
1997
|
| Memo_1 |
Mycoplasma was eliminated with MC-210.
|
|
Lifespan |
infinite
|
| Morphology |
epithelial-like
|
| Cellosaurus(Expasy) |
CVCL_8762
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| |
deposit info |
lot info |
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Medium |
Medium List |
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Culture type |
|
Adherent cells
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| Culture medium |
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HamF10 + 10% FBS
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| Antibiotics |
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Free
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|
Passage method |
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0.25% Trypsin
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Culture information
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Passage ratio |
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1 : 8 split
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| SC frequency |
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Subculture : once/10-14 days, Medium Renewal : 2 times/week
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| Temperature |
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37
℃
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| CO2 concentration |
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5
%
|
| Freeze medium |
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Medium + 10% DMSO
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| Freezing method |
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Slow freezing
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| Mycoplasma/Acholeplasma |
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(-)
|
| Virus (HIV) |
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(-)
|
| Isozyme |
|
LD, NP
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| Chromosome mode |
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59-130(50) : /61(8),62(13),63(8),64(11)/
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| STR(human) |
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OK
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| Images |
deposit info | lot info |
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| Reference information |
Reference |
6
|
| User's Publication |
8
|
| Reference |
|
2029
Okabe T, Kasuga T
Clonal heterogeneity of a human functioning tumor which produces granulocyte colony-stimulating factor.
Jpn J Clin Oncol
1990
20:349-55
PubMed ID: 1704443
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1998
Sato K, Fujii Y, Kakiuchi T, Kasono K, Imamura H, Kondo Y, Mano H, Okabe T, Asano S, Takaku F, et al.
Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor.
Cancer Res
1989
49:4740-6
PubMed ID: 2474371
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2018
Sato K, Mimura H, Han, D C, Kakiuchi T, Ueyama Y, Ohkawa H, Okabe T, Kondo Y, Ohsawa N, Tsushima T, et al.
Production of bone-resorbing activity and colony-stimulating activity in vivo and in vitro by a human squamous cell carcinoma associated with hypercalcemia and leukocytosis.
J Clin Invest
1986
78:145-54
PubMed ID: 3487554
DOI: 10.1172/JCI112544
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2019
Okabe T, Takaku F
Long-term cultivation of a human colony-stimulating factor-producing cell line in a protein-free chemically defined medium.
Cancer Res
1984
44:4503-6
PubMed ID: 6331879
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|
2051
Okabe T, Suzuki A, Ohsawa N, Kosaka K, Terasima T.
Immune elimination of host fibroblasts for the cultivation of human tumors transplanted into nude mice.
Cancer Res
1979
39(10):4189-94
PubMed ID: 476654
|
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2017
Okabe T, Sato N, Kondo Y, Asano S, Ohsawa N, Kosaka K, Ueyama Y
Establishment and characterization of a human cancer cell line that produces human colony-stimulating factor.
Cancer Res
1978
38:3910-7
PubMed ID: 308840
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| User's Publication |
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9935
Suganya S AA, Kochurani KJ, Nair MG, Louis JM, Sankaran S, Rajagopal R, Kumar KS, Abraham P, P G B, Sebastian P, Somananthan T, Maliekal TT.
TM1-IR680 peptide for assessment of surgical margin and lymph node metastasis in murine orthotopic model of oral cancer.
Sci Rep
2016
6:36726
PubMed ID: 27827443
DOI: 10.1038/srep36726
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6344
Parvathy M, Sreeja S, Kumar R, Pillai MR.
Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.
BMC Cancer.
2016
16 Suppl 1:293
PubMed ID: 27229476
DOI: 10.1186/s12885-016-2263-8
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6099
Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A.
Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer.
Oral Oncol
2012
48(11):1120-7
PubMed ID: 22694909
DOI: 10.1016/j.oraloncology.2012.05.009
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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6141
Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.
Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.
Cancer Sci
2008
99(7):1390-400
PubMed ID: 18452558
DOI: 10.1111/j.1349-7006.2008.00838.x
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2906
Nishimaki, Haruaki, Kasai, Kenji, Kozaki, Ken ichi, Takeo, Tomohiro, Ikeda, Hiroshi, Saga, Shinsuke, Nitta, Masakazu, Itoh, Gen
A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line.
Biochem Biophys Res Commun
2004
314:313-20
PubMed ID: 14733907
DOI: 10.1016/j.bbrc.2003.12.097
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6156
Nakayama S, Sasaki A, Mese H, Alcalde RE, Tsuji T, Matsumura T.
The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas.
Int J Cancer.
2001
93(5):667-73
PubMed ID: 11477576
DOI: 10.1002/ijc.1386
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1920
Nagai M, Kyakumoto S, Sato N.
Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation
Biochem Biophys Res Commun
2000
269(2):532-6
PubMed ID: 10708588
DOI: 10.1006/bbrc.2000.2314
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