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Cell No. : Cell Name
RCB1009 : ECC12  update : 2020/09/24
CommentSmall cell gastrointestinal carcinoma showing creatine kinase-BB and aromatic L-amino-acid decarboxy. Cell growth is slow. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Motoyama, Teiichi
Originator Ishihara, Noriko
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 63 years
Tissue stomach, subcutis
Case history small-cell gastrointestinal
Metastastatic ability Yes
Metastatsd tissue liver
Genetics small-cell gastrointestinal
Classification cancer
Year of origin 1986
History originator
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/2-3 weeks, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 40-52(50) : /47(4), 48(23), 49(5), 50(8), 51(1)/
Images
deposit info
lot info
Reference information Reference 0
User's Publication 6


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Reference

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User's Publication
6405  Matsuo K, Taniguchi K, Hamamoto H, Ito Y, Futaki S, Inomata Y, Shima T, Asakuma M, Lee SW, Tanaka K, Okuda J, Kondo Y, Uchiyama K.  Delta-like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy.  Cancer Sci  2019  110(10):3122-3131  PubMed ID: 31369178
6413  Lin JX, Weng XF, Xie XS, Lian NZ, Qiu SL, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Yang YH, Liu SJ, Hu M, Lin YK, Huang CM, Zheng CH, Li P, Xie JW.  CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling.  Cancer Cell Int  2019  7;19:282  PubMed ID: 31728130
5302  Yamaguchi H, Takanashi M, Yoshida N, Ito Y, Kamata R, Fukami K, Yanagihara K, Sakai R.  Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors.  Cancer Sci  2014  105(5):528-36  PubMed ID: 24612061
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
6412  Shida T, Furuya M, Nikaido T, Hasegawa M, Koda K, Oda K, Miyazaki M, Kishimoto T, Nakatani Y, Ishikura H.  Sonic Hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas.  Cancer Biol Ther  2006  5(11):1530-8  PubMed ID: 17102592
1783  Fujiwara T, Motoyama T, Ishihara N, Watanabe H, Kumanishi T, Kato K, Ichinose H, Nagatsu T  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.  Int J Cancer  1993  54:965-71  PubMed ID: 8392984



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