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Cell No. : Cell Name
RCB1003 : MKN1  update : 2022/08/30
CommentPotentially differentiatable to both direction of adenomatous and squamous epithelial cells.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 72 years
Tissue stomach, lymph node meta
Disease name Gastric cancer.
Metastastatic ability Yes
Metastatsd tissue lymph node
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1415
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 63-71(50) : /65(5),66(5),67(6),68(5),69(17),70(6)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 7
User's Publication 84


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Reference
4399  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921   DOI: 10.1111/j.1349-7006.2005.00133.x
4501  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123   DOI: 10.1158/1078-0432.ccr-03-0107
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682   DOI: 10.1111/j.1349-7006.1990.tb03332.x
1890  Aizawa K, Motoyama T, Watanabe H  Placental alkaline phosphatase-like isoenzymes produced by human gastric cancer cells.  Acta Pathol Jpn  1989  39:630-7  PubMed ID: 2686348   DOI: 10.1111/j.1440-1827.1989.tb02409.x
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141  
4427  Hirata Y, Uchihashi M, Fujita T, Matsukura S, Motoyama T, Kaku M, Koshimizu K.  Characteristics of specific binding of epidermal growth factor (EGF) on human tumor cell lines.  Endocrinol Jpn  1983  30(5):601-7  PubMed ID: 6323154   DOI: 10.1507/endocrj1954.30.601

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User's Publication
20478  Xu J, Zhou Y, Yang J, Gu Y, Zhang E, Yuan W, Wang C, Jin G, Ma H, Hu Z.  Hypomethylation-activated cancer-testis gene LIN28B promotes cell proliferation and metastasis in gastric cancer.  Gene  2022  146115  PubMed ID: 34902508   DOI: 10.1016/j.gene.2021.146115
20571  Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.  Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.  Gastric Cancer  2022    PubMed ID: 35166958   DOI: 10.1007/s10120-022-01283-z
20593  Ebert K, Haffner I, Zwingenberger G, Keller S, Raimúndez E, Geffers R, Wirtz R, Barbaria E, Hollerieth V, Arnold R, Walch A, Hasenauer J, Maier D, Lordick F, Luber B.  Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies-the role of HAS2, SHB and HBEGF.  BMC Cancer  2022  22(1):254  PubMed ID: 35264144   DOI: 10.1186/s12885-022-09335-4
20664  Han Y, Dong Q, Liu T, Chen X, Yu C, Zhang Y.  The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.  Biochem Biophys Res Commun  2022  610:1-7  PubMed ID: 35461070   DOI: 10.1016/j.bbrc.2022.04.029
17107  Liu B, Katoh H, Komura D, Yamamoto A, Ochi M, Onoyama T, Abe H, Ushiku T, Seto Y, Suo J, Ishikawa S.  Functional genomics screening identifies aspartyl-tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers  J Pathol  2022  2022 Jun 13  PubMed ID: 35696251   DOI: 10.1002/path.5980
20887  Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W.  MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.  Theranostics  2022  12(15):6509-6526  PubMed ID: 36185598   DOI: 10.7150/thno.75431
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
13647  Hikita K, Yamakage Y, Okunaga H, Motoyama Y, Matsuyama H, Matsuoka K, Murata T, Nakayoshi T, Oda A, Kato K, Tanaka H, Asao N, Dan S, Kaneda N.  (S)-Erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells  Bioorg Med Chem  2021  30:115904.  PubMed ID: 33341500   DOI: 10.1016/j.bmc.2020.115904
14347  Matsumura S, Nakamori M, Tsuji T, Kato T, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H.  Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer  Oncotarget  2021  12(4):344-354  PubMed ID: 33659045   DOI: 10.18632/oncotarget.27873
20415  Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T.  Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.  Oncol Lett  2021  22(4):735  PubMed ID: 34466148   DOI: 10.3892/ol.2021.12996
11819  Moro H, Hattori N, Nakamura Y, Kimura K, Imai T, Maeda M, Yashiro M, Ushijima T.  Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.  Gastric Cancer  2020  23(1):105-115  PubMed ID: 31555951   DOI: 10.1007/s10120-019-01010-1
12039  Kim JH, Park S, Lim SM, Eom HJ, Balch C, Lee J, Kim GJ, Jeong JH, Nam S, Kim YH.  Rational design of small molecule RHOA inhibitors for gastric cancer.  Pharmacogenomics J.  2020    PubMed ID: 32015453   DOI: 10.1038/s41397-020-0153-6
13242  Uejima C, Morimoto M, Yamamoto M, Hara K, Miyauchi W, Sugezawa K, Tada Y, Tanio A, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y.  Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer.  Anticancer Res  2020  40(10):5593-5600  PubMed ID: 32988883   DOI: 10.21873/anticanres.14572
13315  Ebert K, Zwingenberger G, Barbaria E, Keller S, Heck C, Arnold R, Hollerieth V, Mattes J, Geffers R, Raimúndez E, Hasenauer J, Luber B.  Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines.  BMC Cancer  2020    PubMed ID: 33115415   DOI: 10.1186/s12885-020-07540-7
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217   DOI: 10.1016/j.bbrep.2019.100632
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826   DOI: 10.1038/s41586-019-1103-9
11499  S Zhang et al  Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation  BPB Reports  2019  2,130-133   
10766  Devanand P, Oya Y, Sundaramoorthy S, Song KY, Watanabe T, Kobayashi Y, Shimizu Y, Hong SA, Suganuma M, Lim IK.  Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2/TIS21 via downregulating cytoplasmic nucleolin expression.  Exp. Mol. Med.  2018  50:e449  PubMed ID: 29472702   DOI: 10.1038/emm.2017.281
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
11282  Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H.  The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis.  Anticancer Res.  2018    PubMed ID: 30396946   DOI: 10.21873/anticanres.12982
11338  Oku T, Shimada K, Kenmotsu H, Ando Y, Kurisaka C, Sano R, Tsuiji M, Hasegawa S, Fukui T, Tsuji T.  Stimulation of Peritoneal Mesothelial Cells to Secrete Matrix Metalloproteinase-9 (MMP-9) by TNF-α: A Role in the Invasion of Gastric Carcinoma Cells.  Int J Mol Sci  2018    PubMed ID: 30544870   DOI: 10.3390/ijms19123961
4425    Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients  PharmaNutrition  2018  6,100-106    DOI: 10.1016/j.phanu.2018.05.003
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864   DOI: 10.3892/or.2017.6093
4300  Keller S, Zwingenberger G, Ebert K, Hasenauer J, Wasmuth J, Maier D, Haffner I, Schierle K, Weirich G, Luber B.  Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines.  Mol Oncol  2018    PubMed ID: 29325228   DOI: 10.1002/1878-0261.12170
5801  Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z.  Targeting IRF3 as a YAP agonist therapy against gastric cancer.  J Exp Med  2018  215(2):699-718  PubMed ID: 29339449   DOI: 10.1084/jem.20171116
13126  Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K.  Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.  Cancer Sci  2018    PubMed ID: 30290054   DOI: 10.1111/cas.13824
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839   DOI: 10.1007/s10120-016-0627-z
10098  Ito C, Nishizuka SS, Ishida K, Uesugi N, Sugai T, Tamura G, Koeda K, Sasaki A.  Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer.  J. Surg. Res.  2017  212:195-204  PubMed ID: 28550907   DOI: 10.1016/j.jss.2017.01.018
4550  Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G.  Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.  Nat Commun  2017  8(1):1707  PubMed ID: 29167426   DOI: 10.1038/s41467-017-01645-7
5804  Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki  Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26  Oncology Letters  2017  13(1):215-221  PubMed ID: 28123544   DOI: 10.3892/ol.2016.5386
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
9670  Nukuda A, Endoh H, Yasuda M, Mizutani T, Kawabata K, Haga H.  Role of ATF5 in the invasive potential of diverse human cancer cell lines.  Biochem. Biophys. Res. Commun.  2016  474:509-514  PubMed ID: 27125458   DOI: 10.1016/j.bbrc.2016.04.131
9731  Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O.  Establishment of anti-mesothelioma monoclonal antibodies.  BMC Res Notes  2016  9:324  PubMed ID: 27342200   DOI: 10.1186/s13104-016-2128-x
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
5818  Feng Y et al  Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion.  Cancer Sci  2015  106(10):1313-22  PubMed ID: 26211905   DOI: 10.1111/cas.12754
14387  Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K, Fukayama M.  Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis  J Virol  2015  89(10):5581-91  PubMed ID: 25740983   DOI: 10.1128/JVI.03639-14
14977  Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y.  CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence  J Surg Oncol  2015  112(6):622-8  PubMed ID: 26416034   DOI: 10.1002/jso.24056
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
5827  Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.  Oncol Rep  2014  31(1):27-33  PubMed ID: 24146039   DOI: 10.3892/or.2013.2803
5828  Watanabe T, Takahashi A, Suzuki K, Kurusu-Kanno M, Yamaguchi K, Fujiki H, Suganuma M.  Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori.  Int J Cancer  2014  134(10):2373-82  PubMed ID: 24249671   DOI: 10.1002/ijc.28582
6398  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629   DOI: 10.1016/j.bbrc.2014.06.007
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082   DOI: 10.1371/journal.pone.0056766
9102  Toshiaki Tsuji, Mikihito Nakamori, Makoto Iwahashi, Masaki Nakamura, Toshiyasu Ojima, Takeshi Iida, Masahiro Katsuda, Keiji Hayata, Yasushi Ino, Tomoki Todo, Hiroki Yamaue  An Armed Oncolytic Herpes Simplex Virus Expressing thrombospondin-1 Has an Enhanced in Vivo Antitumor Effect Against Human Gastric Cancer  Int J Cancer  2013  132 (2), 485-94  PubMed ID: 22729516   DOI: 10.1002/ijc.27681
7628  Kamoshida G, Matsuda A, Sekine W, Mizuno H, Oku T, Itoh S, Irimura T, Tsuji T.  Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix.  Cancer Lett.  2012  315:145-52  PubMed ID: 22104730   DOI: 10.1016/j.canlet.2011.09.029
5848  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.  Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.  Invest New Drugs  2012  30(4):1352-60  PubMed ID: 21655918   DOI: 10.1007/s10637-011-9699-0
5850  Miyato H, Tsuno NH, Kitayama J.  Semaphorin 3C is involved in the progression of gastric cancer.  Cancer Sci  2012  103(11):1961-6  PubMed ID: 22924992   DOI: 10.1111/cas.12003
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071   DOI: 10.3892/ijo.2012.1485
7876  Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489   DOI: 10.1245/s10434-011-1636-0
8253  Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2011  128:1293-302  PubMed ID: 20473946   DOI: 10.1002/ijc.25459
5865  Nakata W, Hayakawa Y, Nakagawa H, Sakamoto K, Kinoshita H, Takahashi R, Hirata Y, Maeda S, Koike K.  Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer.  Int J Oncol  2011  39(6):1529-36  PubMed ID: 21785822   DOI: 10.3892/ijo.2011.1141
5866  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.  Am J Pathol  2011  178(2):515-24  PubMed ID: 21281785   DOI: 10.1016/j.ajpath.2010.10.010
6115  Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S.  Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers.  Oncol Rep  2011  26(6):1385-92  PubMed ID: 21894439   DOI: 10.3892/or.2011.1450
8110  Ramachandran S, Shida D, Nagahashi M, Fang X, Milstien S, Takabe K, Spiegel S.  Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.  FEBS Lett.  2010  584:4077-82  PubMed ID: 20804754   DOI: 10.1016/j.febslet.2010.08.035
8315  Saito Y, Sekine W, Sano R, Komatsu S, Mizuno H, Katabami K, Shimada K, Oku T, Tsuji T.  Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.  Clin. Exp. Metastasis  2010  27:197-205  PubMed ID: 20352300   DOI: 10.1007/s10585-010-9314-3
5868  Tsunemi S, Nakanishi T, Fujita Y, Bouras G, Miyamoto Y, Miyamoto A, Nomura E, Takubo T, Tanigawa N.  Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.  Oncol Rep  2010  23(4):949-56  PubMed ID: 20204278   DOI: 10.3892/or_00000719
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
5882  Shichiri M, Fukai N, Kono Y, Tanaka Y.  Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancers.  Cancer Res  2009  69(11):4760-8  PubMed ID: 19458074   DOI: 10.1158/0008-5472.CAN-08-3417
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
5886  Inoue M, Matsumoto S, Saito H, Tsujitani S, Ikeguchi M.  Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer.  Int J Cancer.   2008  123(11):2696-701  PubMed ID: 18798274   DOI: 10.1002/ijc.23867
12803  Lindén SK, Driessen KM, McGuckin MA.  Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions  Helicobacter  2007  12(4):341-53  PubMed ID: 17669108   DOI: 10.1111/j.1523-5378.2007.00509.x
16154  Higashiyama M, Ito T, Tanaka E, Shimada Y.  Prognostic significance of osteopontin expression in human gastric carcinoma  Ann Surg Oncol  2007  14(12):3419-27  PubMed ID: 17896150   DOI: 10.1245/s10434-007-9564-8
5897  Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M.  Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.  Oncology  2006  70(2):126-33  PubMed ID: 16645325   DOI: 10.1159/000093003
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