Search
CELL BANK Website

Back Back
Cell No. : Cell Name
RCB1002 : MKN74  update : 2022/03/28
CommentModerately differentiated adenocarcinoma. Once they were hypodiploids.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruo
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 37 years
Tissue stomach, liver meta
Disease name Gastric adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue liver
Classification cancer
Year of origin 1975
History Hojo, Haruo - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_2791
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 42-49(50) : 42(2),45(4),46(10),47(25),48(7),49(2)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 6
User's Publication 162


To topTop
Reference
4399  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921   DOI: 10.1111/j.1349-7006.2005.00133.x
4501  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123   DOI: 10.1158/1078-0432.ccr-03-0107
1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675  
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141  
4522  Sakakibara K, Suzuki T, Motoyama T, Watanabe H, Nagai Y.  Biosynthesis of an interstitial type of collagen by cloned human gastric carcinoma cells.  Cancer Res  1982  42(5):2019-27  PubMed ID: 7066911  

To topTop
User's Publication
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20478  Xu J, Zhou Y, Yang J, Gu Y, Zhang E, Yuan W, Wang C, Jin G, Ma H, Hu Z.  Hypomethylation-activated cancer-testis gene LIN28B promotes cell proliferation and metastasis in gastric cancer.  Gene  2022  146115  PubMed ID: 34902508   DOI: 10.1016/j.gene.2021.146115
16170  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.  Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)  ACS Chem Biol  2022  Feb 7.  PubMed ID: 35128925   DOI: 10.1021/acschembio.2c00028
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20625  Ishikawa A, Kuraoka K, Zaitsu J, Saito A, Kuwai T, Tazawa H, Suzuki T, Tashiro H, Taniyama K, Yasui W.  Transcriptomic Analysis of Annexin A10 and Chemosensitivity in Gastric Adenocarcinoma Cells.  Anticancer Res  2022  42(4):1707-1717  PubMed ID: 35346989   DOI: 10.21873/anticanres.15647
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
16979  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  Front Oncol  2022  12:802009  PubMed ID: 35251974   DOI: 10.3389/fonc.2022.802009
13160  Sakuratani T, Takeuchi T, Yasufuku I, Iwata Y, Saigo C, Kito Y, Yoshida K.  Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway.  Virchows Arch  2021  478(3):401-411  PubMed ID: 32789692   DOI: 10.1007/s00428-020-02899-1
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
13414  Yuza K, Nagahashi M, Ichikawa H, Hanyu T, Nakajima M, Shimada Y, Ishikawa T, Sakata J, Takeuchi S, Okuda S, Matsuda Y, Abe M, Sakimura K, Takabe K, Wakai T.  Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer.  J Gastrointest Surg  2021    PubMed ID: 33420656   DOI: 10.1007/s11605-020-04889-9
20005  Iwata Y, Yasufuku I, Saigo C, Kito Y, Takeuchi T, Yoshida K.  Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma.  J Cancer  2021  12(4):1161-1168  PubMed ID: 33442414   DOI: 10.7150/jca.46765
20061  Iwamuro M, Shiraha H, Oyama A, Uchida D, Horiguchi S, Okada H.  Laminin-411 and -511 Modulate the Proliferation, Adhesion, and Morphology of Gastric Cancer Cells.  Cell Biochem Biophys  2021    PubMed ID: 33629255   DOI: 10.1007/s12013-021-00972-3
20098  Tsuji T, Maeda Y, Kita K, Murakami K, Saya H, Takemura H, Inaki N, Oshima M, Oshima H.  FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells.  Oncogene  2021    PubMed ID: 33795838   DOI: 10.1038/s41388-021-01757-x
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
14347  Matsumura S, Nakamori M, Tsuji T, Kato T, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H.  Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer  Oncotarget  2021  12(4):344-354  PubMed ID: 33659045   DOI: 10.18632/oncotarget.27873
20224  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E.  Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer.  Photodiagnosis Photodyn Ther  2021    PubMed ID: 34242818   DOI: 10.1016/j.pdpdt.2021.102420
20324  Abe H, Kunita A, Otake Y, Kanda T, Kaneda A, Ushiku T, Fukayama M.  Virus-host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage.  PLoS One  2021  16(9):e0256440  PubMed ID: 34469459   DOI: 10.1371/journal.pone.0256440
20358  Zhang J, Wang F, Zhang H, Cao M.  A novel circular RNA circ_HN1/miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network regulates gastric cancer development.  Bioengineered  2021    PubMed ID: 34637682   DOI: 10.1080/21655979.2021.1989259
20385  Ito K, Kitajima Y, Kai K, Matsufuji S, Yamada K, Egawa N, Kitagawa H, Okuyama K, Tanaka T, Noshiro H.  Matrix metalloproteinase‑1 expression is regulated by HIF‑1‑dependent and epigenetic mechanisms and serves a tumor‑suppressive role in gastric cancer progression.  Int J Oncol  2021  59(6)  PubMed ID: 34738626   DOI: 10.3892/ijo.2021.5282
20421  Reyna-Jeldes M, De la Fuente-Ortega E, Cerda D, Velázquez-Miranda E, Pinto K, Vázquez-Cuevas FG, Coddou C.  Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines.  Pharmaceutics  2021  13(8)  PubMed ID: 34452195   DOI: 10.3390/pharmaceutics13081234
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
16522  Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.  Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth  ACS Chem Biol  2021  16(8):1576-1586  PubMed ID: 34296611   DOI: 10.1021/acschembio.1c00480
16803  Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H.  Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells  FEBS Open Bio  2021  11(5):1465-1475  PubMed ID: 33773069   DOI: 10.1002/2211-5463.13154
16896  Shiozaki A, Katsurahara K, Kudou M, Shimizu H, Kosuga T, Ito H, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Otsuji E.  Amlodipine and Verapamil, Voltage-Gated Ca 2+ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells  Ann Surg Oncol  2021  28(9):5400-5411  PubMed ID: 33566246   DOI: 10.1245/s10434-021-09645-0
11815  Nakade H, Migita K, Matsumoto S, Wakatsuki K, Kunishige T, Miyao S, Sho M.  Overexpression of Cullin4A correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma.  Int. J. Clin. Oncol.  2020  25(3):446-455  PubMed ID: 31535245   DOI: 10.1007/s10147-019-01547-2
12041  Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S.  FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.  Oncogenesis  2020    PubMed ID: 32029704   DOI: 10.1038/s41389-020-0190-7
13242  Uejima C, Morimoto M, Yamamoto M, Hara K, Miyauchi W, Sugezawa K, Tada Y, Tanio A, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y.  Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer.  Anticancer Res  2020  40(10):5593-5600  PubMed ID: 32988883   DOI: 10.21873/anticanres.14572
13344  Hinata M, Kunita A, Abe H, Morishita Y, Sakuma K, Yamashita H, Seto Y, Ushiku T, Fukayama M.  Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation.  Microorganisms  2020    PubMed ID: 33198173   DOI: 10.3390/microorganisms8111776
13504  Baatar S, Bai T, Yokobori T, Gombodorj N, Nakazawa N, Ubukata Y, Kimura A, Kogure N, Sano A, Sohda M, Sakai M, Tumenjargal A, Ogata K, Kuwano H, Shirabe K, Saeki H.  High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer  Ann Surg Oncol  2020  27(11):4360-4368  PubMed ID: 32356270   DOI: 10.1245/s10434-020-08518-2
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
13626  Migita K, Matsumoto S, Wakatsuki K, Kunishige T, Nakade H, Miyao S, Sho M.  RNF126 as a Marker of Prognosis and Proliferation of Gastric Cancer  Anticancer Res  2020  40(3):1367-1374  PubMed ID: 32132033   DOI: 10.21873/anticanres.14078
13838  He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S.  MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression  FASEB J  2020  34(6):8544-8557  PubMed ID: 32356314   DOI: 10.1096/fj.201903217R
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
6418  Hevia MJ, Castro P, Pinto K1, Reyna-Jeldes M, Rodríguez-Tirado F, Robles-Planells C, Ramírez-Rivera S, Madariaga JA, Gutierrez F, López J, Barra M, De la Fuente-Ortega E, Bernal G, Coddou C.  Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors.  Front Pharmacol  2019  10:612  PubMed ID: 31249523   DOI: 10.3389/fphar.2019.00612
11641  Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.  Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 31351225   DOI: 10.1016/j.bbalip.2019.07.010
11499  S Zhang et al  Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation  BPB Reports  2019  2,130-133   
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007   DOI: 10.1038/s41416-018-0008-y
10796  Matsuoka K, Nakagawa F, Kobunai T, Takechi T.  Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression.  Oncotarget  2018  9:13438-13450  PubMed ID: 29568368   DOI: 10.18632/oncotarget.24412
11095  Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH.  Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.  PLoS ONE  2018  13(6):e0198347  PubMed ID: 29874279   DOI: 10.1371/journal.pone.0198347
11219  Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H.  Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.  Oncol Lett  2018    PubMed ID: 30250614   DOI: 10.3892/ol.2018.9301
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
4299  Yoshida J, Abe H, Watanabe T, Kawada M.  Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.  Oncol Lett  2018    PubMed ID: 30405822   DOI: 10.3892/ol.2018.9485
4303  Afroz S, Yagi A, Fujikawa K, Rahman MM, Morito K, Fukuta T, Watanabe S, Kiyokage E, Toida K, Shimizu T, Ishida T, Kogure K, Tokumura A, Tanaka T.  Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro.  Prostaglandins Other Lipid Mediat.  2018    PubMed ID: 29462674   DOI: 10.1016/j.prostaglandins.2018.01.003
4304  Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X.  Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.  Oncol Lett  2018    PubMed ID: 29805691   DOI: 10.3892/ol.2018.8562
13126  Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K.  Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.  Cancer Sci  2018    PubMed ID: 30290054   DOI: 10.1111/cas.13824
14733  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma  Carcinogenesis  2018  39(2):263-271  PubMed ID: 29228320   DOI: 10.1093/carcin/bgx139
14901  Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K.  Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis  Mol Cancer Res  2018  16(3):554-563  PubMed ID: 29330298   DOI: 10.1158/1541-7786.MCR-17-0393
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839   DOI: 10.1007/s10120-016-0627-z
10177  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.  Oncol Lett  2017  13:3127-3130  PubMed ID: 28521417   DOI: 10.3892/ol.2017.5836
10253  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433   DOI: 10.3892/ol.2017.5987
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175   DOI: 10.3892/or.2017.5844
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808   DOI: 10.18632/oncotarget.20209
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969   DOI: 10.18632/oncotarget.20860
4426    Biological activity of intervenolin analogs with a phenyl substituent  The Journal of Antibiotics  2017  71, 86–90  PubMed ID: 29018268   DOI: 10.1038/ja.2017.123
5806  Shiroki T et al  Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.  Cancer Sci  2017  108(5):931-940  PubMed ID: 28235245   DOI: 10.1111/cas.13211
13680  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Proliferation and motility of hepatocellular, pancreatic and gastric cancer cells grown in a medium without glucose and arginine, but with galactose and ornithine  Oncol Lett  2017  13(3):1276-1280  PubMed ID: 28454246   DOI: 10.3892/ol.2017.5568
14242  Wakiyama K, Kitajima Y, Tanaka T, Kaneki M, Yanagihara K, Aishima S, Nakamura J, Noshiro H.  Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis  Sci Rep  2017  7(1):12653  PubMed ID: 28978999   DOI: 10.1038/s41598-017-12929-9
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14735  Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS.  Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil  Sci Rep  2017  7(1):2262  PubMed ID: 28536445   DOI: 10.1038/s41598-017-02548-9
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
14746  Chen Z, Hu T, Zhu S, Mukaisho K, El-Rifai W, Peng DF.  Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer  Oncotarget  2017  8(33):54345-54356  PubMed ID: 28903346   DOI: 10.18632/oncotarget.17527
9573  Maeda Y, Echizen K, Oshima H, Yu L, Sakulsak N, Hirose O, Yamada Y, Taniguchi T, Jenkins BJ, Saya H, Oshima M.  Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.  Cancer Prev Res (Phila)  2016  9:253-63  PubMed ID: 26888865   DOI: 10.1158/1940-6207.CAPR-15-0315
9610  Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M.  Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.  Nat Microbiol  2016  1:16026  PubMed ID: 27572445   DOI: 10.1038/nmicrobiol.2016.26
9678  Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, Ohata Y, Akashi T, Saitoh M, Harada K, Harada H, Yamaguchi A.  NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma.  PLoS ONE  2016  11:e0154112  PubMed ID: 27124156   DOI: 10.1371/journal.pone.0154112
9679  Narukawa Y, Komatsu C, Yamauchi R, Shibayama S, Hachisuka M, Kiuchi F.  Two new lignans and melanogenesis inhibitors from Schisandra nigra.  J Nat Med  2016  70:460-6  PubMed ID: 27142263   DOI: 10.1007/s11418-016-1000-6
9681  Widyowati R, Sugimoto S, Yamano Y, Sukardiman , Otsuka H, Matsunami K.  New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica.  Chem. Pharm. Bull.  2016  64:517-21  PubMed ID: 27150486   DOI: 10.1248/cpb.c16-00073
9684  Isono T, Chano T, Yonese J, Yuasa T.  Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas.  Sci Rep  2016  6:25669  PubMed ID: 27157976   DOI: 10.1038/srep25669
9685  Gao J, Fu S, Zeng Z, Li F, Niu Q, Jing D, Feng X.  Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism.  Mol Med Rep  2016  14:218-24  PubMed ID: 27177232   DOI: 10.3892/mmr.2016.5239
3733  Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S.  Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer.  Oncotarget  2016  7(41):67251-67265  PubMed ID: 27572307   DOI: 10.18632/oncotarget.11625
5811  Maejima R et al  Enhanced expression of semaphorin 3E is involved in the gastric cancer development.  Int J Oncol  2016  49(3):887-94  PubMed ID: 27572291   DOI: 10.3892/ijo.2016.3593
12639  Yamashita K, Kuno A, Matsuda A, Ikehata Y, Katada N, Hirabayashi J, Narimatsu H, Watanabe M.  Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer  Gastric Cancer  2016  19(2):531-54  PubMed ID: 25840959   DOI: 10.1007/s10120-015-0491-2
12874  Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H.  Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients  Gastric Cancer  2016  19(3):789-97.  PubMed ID: 26472729   DOI: 10.1007/s10120-015-0551-7
12913  Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E.  Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells  Oncotarget  2016  7(35):56855-56863  PubMed ID: 27487135   DOI: 10.18632/oncotarget.10869
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
12968  Kimura A, Ogata K, Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Yanoma T, Suzuki M, Bai T, Oyama T, Kuwano H.  Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer  Oncotarget  2016  7(14):18415-23  PubMed ID: 26943774   DOI: 10.18632/oncotarget.7821
14146  B Rupavani, V Peesapati, V G M Naiduc & S Ramakrishnad  Synthesis of some new physiologically active polyheterocycles derived from benzocyclohepten-5-ones  Indian Journal of Chemistry  2016  55B:88-93   
7097  Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566   DOI: 10.1371/journal.pone.0146026
7255  Nukatsuka M, Nakagawa F, Takechi T.  Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts.  Anticancer Res.  2015  35:4605-15  PubMed ID: 26254349  
7512  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.  Int. J. Oncol.  2015  46:1018-24  PubMed ID: 25586465   DOI: 10.3892/ijo.2015.2830
5816  Xianqiang Liu, Meili Sun, Shui Yu, Kai Liu, Xirui Li, and Huan Shi  Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells  Onco Targets Ther  2015  8:3095–3104  PubMed ID: 26543378   DOI: 10.2147/OTT.S91122
5819  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.  CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.  Cancer Med  2015  4(9):1322-33  PubMed ID: 26077800   DOI: 10.1002/cam4.478
6064  Tanaka T et al  The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions.  PLoS One  2015  10(9):e0137257  PubMed ID: 26339797   DOI: 10.1371/journal.pone.0137257
13701  Fujimoto D, Ueda Y, Hirono Y, Goi T, Yamaguchi A.  PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway  Oncotarget  2015  6(33):34788-99  PubMed ID: 26431277   DOI: 10.18632/oncotarget.5858
14977  Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y.  CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence  J Surg Oncol  2015  112(6):622-8  PubMed ID: 26416034   DOI: 10.1002/jso.24056
15000  Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S.  DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells  PLoS One  2015  10(12):e0145630  PubMed ID: 26695186   DOI: 10.1371/journal.pone.0145630
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
5827  Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.  Oncol Rep  2014  31(1):27-33  PubMed ID: 24146039   DOI: 10.3892/or.2013.2803
5829  Tanaka T, Ohmoto M, Morito K, Kondo H, Urikura M, Satouchi K, Tokumura A.  Type 2 lysophosphatidic acid receptor in gastric surface mucous cells: Possible implication of prostaglandin E2 production.  Biofactors  2014  40(3):355-61  PubMed ID: 24375908   DOI: 10.1002/biof.1147
12542  Suzuki R, Aruga A, Kobayashi H, Yamato M, Yamamoto M.  Development of a novel in vivo cancer model using cell sheet engineering  Anticancer Res  2014  34(9):4747-54.  PubMed ID: 25202053  
15817  Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G.  A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines  PLoS One  2014  9(2):e90155  PubMed ID: 24587255   DOI: 10.1371/journal.pone.0090155
15903  Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T.  Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin  Cancer Biol Ther  2014  15(1):81-8  PubMed ID: 24149371   DOI: 10.4161/cbt.26610
16006  Ramesh V, Ananda Rao B, Sharma P, Swarna B, Thummuri D, Srinivas K, Naidu VG, Jayathirtha Rao V.  Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo[h]quinoline scaffolds as anticancer agents  Eur J Med Chem  2014  83:569-80  PubMed ID: 24996143   DOI: 10.1016/j.ejmech.2014.06.013
16016  Nakamura A, Nakajima G, Okuyama R, Kuramochi H, Kondoh Y, Kanemura T, Takechi T, Yamamoto M, Hayashi K.  Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase  Gastric Cancer  2014  17(1):188-95  PubMed ID: 23494117   DOI: 10.1007/s10120-013-0249-7
16650  Otsuki T, Fujimoto D, Hirono Y, Goi T, Yamaguchi A.  Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer  Int J Oncol  2014  45(6):2287-94  PubMed ID: 25231630   DOI: 10.3892/ijo.2014.2651
17126  Migita K, Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Ito M, Nishiwada S, Nakajima Y.  Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer  Gastric Cancer  2014  17(4):601-9  PubMed ID: 24292229   DOI: 10.1007/s10120-013-0318-y
5838  Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh  Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer.  PLoS One  2013  8(10):e77070  PubMed ID: 24130837   DOI: 10.1371/journal.pone.0077070
5840  Kawada M, Inoue H, Ohba S, Hatano M, Amemiya M, Hayashi C, Usami I, Abe H, Watanabe T, Kinoshita N, Igarashi M, Masuda T, Ikeda D, Nomoto   Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.  J Antibiot (Tokyo)  2013  66(9):543-8  PubMed ID: 23632919   DOI: 10.1038/ja.2013.42
9102  Toshiaki Tsuji, Mikihito Nakamori, Makoto Iwahashi, Masaki Nakamura, Toshiyasu Ojima, Takeshi Iida, Masahiro Katsuda, Keiji Hayata, Yasushi Ino, Tomoki Todo, Hiroki Yamaue  An Armed Oncolytic Herpes Simplex Virus Expressing thrombospondin-1 Has an Enhanced in Vivo Antitumor Effect Against Human Gastric Cancer  Int J Cancer  2013  132 (2), 485-94  PubMed ID: 22729516   DOI: 10.1002/ijc.27681
15775  Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K.  Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis  PLoS One  2013  8(4):e60914  PubMed ID: 23593346   DOI: 10.1371/journal.pone.0060914
5848  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.  Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.  Invest New Drugs  2012  30(4):1352-60  PubMed ID: 21655918   DOI: 10.1007/s10637-011-9699-0
5850  Miyato H, Tsuno NH, Kitayama J.  Semaphorin 3C is involved in the progression of gastric cancer.  Cancer Sci  2012  103(11):1961-6  PubMed ID: 22924992   DOI: 10.1111/cas.12003
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071   DOI: 10.3892/ijo.2012.1485
6104  Hiraki M, Kitajima Y, Kai K, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Knockdown of hypoxia-inducible factor-1α accelerates peritoneal dissemination via the upregulation of MMP-1 expression in gastric cancer cell lines.  Exp Ther Med  2012  4(3):355-362  PubMed ID: 23181099   DOI: 10.3892/etm.2012.600
15746  Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K.  Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer  Cancer Sci  2012  103:2181-5  PubMed ID: 23110662   DOI: 10.1111/cas.12024
7876  Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489   DOI: 10.1245/s10434-011-1636-0
7937  Saito S, Tomida A.  Use of chemical genomics in assessment of the UPR.  Meth. Enzymol.  2011  491:327-41  PubMed ID: 21329808   DOI: 10.1016/B978-0-12-385928-0.00018-3
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856   DOI: 10.1038/sj.bjc.6606075
8253  Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M.  Reduced expression of RAS protein activator like-1 in gastric cancer.  Int. J. Cancer  2011  128:1293-302  PubMed ID: 20473946   DOI: 10.1002/ijc.25459
5890  Matsunaga T, Saito H, Ikeguchi M.  Increased B7-H1 and B7-H4 Expressions on Circulating Monocytes and Tumor-Associated Macrophages are Involved in Immune Evasion in Patients with Gastric Cancer.  Yonago Acta Med  2011  54(1):1-10  PubMed ID: 24031123  
5866  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.  Am J Pathol  2011  178(2):515-24  PubMed ID: 21281785   DOI: 10.1016/j.ajpath.2010.10.010
6115  Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S.  Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers.  Oncol Rep  2011  26(6):1385-92  PubMed ID: 21894439   DOI: 10.3892/or.2011.1450
16307  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M.  Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer  BMC Cancer  2011  11:122  PubMed ID: 21466710   DOI: 10.1186/1471-2407-11-122
8325  Otani K, Kitayama J, Kamei T, Soma D, Miyato H, Yamauchi T, Kadowaki T, Nagawa H.  Adiponectin receptors are downregulated in human gastric cancer.  J. Gastroenterol.  2010  45:918-27  PubMed ID: 20336470   DOI: 10.1007/s00535-010-0228-2
8416  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy.  Int. J. Cancer  2009  127:1158-71  PubMed ID: 20020496   DOI: 10.1002/ijc.25129
8520  Kim JC, Shin ES, Kim CW, Roh SA, Cho DH, Na YS, Kim TW, Kim MB, Hyun YL, Ro S, Kim SY, Kim YS.  In vitro evaluation of histone deacetylase inhibitors as combination agents for colorectal cancer.  Anticancer Res.  2009  29:3027-34  PubMed ID: 19661311  
8590  Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, Nagawa H.  Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.  J. Surg. Res.  2009  155:40-7  PubMed ID: 19394652   DOI: 10.1016/j.jss.2008.06.045
5031  Ohnuma S, Miura K, Horii A, Fujibuchi W, Kaneko N, Gotoh O, Nagasaki H, Mizoi T, Tsukamoto N, Kobayashi T, Kinouchi M, Okabe M, Sasaki H, Shiiba K, Miyagawa K, Sasaki I.  Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues.  Surgery  2009  145(1):57-68  PubMed ID: 19081476   DOI: 10.1016/j.surg.2008.08.010
5874  Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.  p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.  Am J Physiol Gastrointest Liver Physiol  2009  297(2):G385-96  PubMed ID: 19541923   DOI: 10.1152/ajpgi.90620.2008
5876  Takaishi S1, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.  Identification of gastric cancer stem cells using the cell surface marker CD44.  Stem Cells.   2009  27(5):1006-20  PubMed ID: 19415765   DOI: 10.1002/stem.30
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
5893  Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T.  Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.  Clin Exp Metastasis  2007  24(3):179-89  PubMed ID: 17487561   DOI: 10.1007/s10585-007-9067-9
16154  Higashiyama M, Ito T, Tanaka E, Shimada Y.  Prognostic significance of osteopontin expression in human gastric carcinoma  Ann Surg Oncol  2007  14(12):3419-27  PubMed ID: 17896150   DOI: 10.1245/s10434-007-9564-8
5897  Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M.  Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.  Oncology  2006  70(2):126-33  PubMed ID: 16645325   DOI: 10.1159/000093003
5899  Yokoyama H, Ikehara Y, Kodera Y, Ikehara S, Yatabe Y, Mochizuki Y, Koike M, Fujiwara M, Nakao A, Tatematsu M, Nakanishi H.  Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.  Br J Cancer  2006  95(11):1504-13  PubMed ID: 17088902   DOI: 10.1038/sj.bjc.6603459
5902  Mori A, Asano T, Maruyama T, Ohashi N, Inoue H, Takekoshi S, Okuno M.  Transnasal ERCP/ENBD using an ultrathin esophagogastroduodenoscope.  J Gastroenterol  2006  41(12):1237-8  PubMed ID: 17287905   DOI: 10.1007/s00535-006-1911-1
3376  Shida, Dai, Kitayama, Joji, Mori, Ken, Watanabe, Toshiaki, Nagawa, Hirokazu  Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.  Cancer Res  2005  65:9159-63  PubMed ID: 16230373   DOI: 10.1158/0008-5472.CAN-05-0598
3109  Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780   DOI: 10.1089/dna.2005.24.141
3167  Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789   DOI: 10.1248/bpb.28.574
3375  Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228   DOI: 10.1158/0008-5472.CAN-05-0777
5919  Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi  The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines  Yonago Acta medica  2005  48:7–16   
6449  Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M.  Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping.  World J Gastroenterol  2005  11(33):5129-35  PubMed ID: 16127741   DOI: 10.3748/wjg.v11.i33.5129
12834  Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y.  Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori  Mol Biol Cell  2005  16(10):4954-66.  PubMed ID: 16030249   DOI: 10.1091/mbc.e05-05-0426
2807  Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H  Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.  Exp Cell Res  2004  301:168-78  PubMed ID: 15530853   DOI: 10.1016/j.yexcr.2004.08.008
3206  Wen, Xian-Zi, Miyake, Satoshi, Akiyama, Yoshimitsu, Yuasa, Yasuhito  BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells.  Biochem Biophys Res Commun  2004  316:100-6  PubMed ID: 15003517   DOI: 10.1016/j.bbrc.2004.02.016
3105  Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H  Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma.  Eur J Clin Invest  2004  34:605-12  PubMed ID: 15379759   DOI: 10.1111/j.1365-2362.2004.01401.x
5922  Meng H, Lu C, Mabuchi H, Tanigawa N.  Prognostic significance and different properties of survivin splicing variants in gastric cancer.  Cancer Lett  2004  216(2):147-55  PubMed ID: 15533590   DOI: 10.1016/j.canlet.2003.12.020
5923  Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H.  Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.  Pharmacol Res.   2004  50(1):65-76  PubMed ID: 15082031   DOI: 10.1016/j.phrs.2003.12.015
5924  Oyama K, Terashima M, Takagane A, Maesawa C.  Prognostic significance of peritoneal minimal residual disease in gastric cancer detected by reverse transcription-polymerase chain reaction.  Br J Surg  2004  91(4):435-43  PubMed ID: 15048743   DOI: 10.1002/bjs.4455
3103  Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao  Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines.  Int J Oncol  2003  23:713-9  PubMed ID: 12888908  
5931  Terashima M, Fujiwara H, Takagane A, Abe K, Irinoda T, Nakaya T, Yonezawa H, Oyama K, Saito K, Kanzaki N, Ohtani S, Nemoto T, Hoshino Y, Kogure M, Gotoh M.  Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer.  Gastric Cancer  2003  6 Suppl 1:71-81.  PubMed ID: 12775024   DOI: 10.1007/s10120-003-0221-z
5932  Fujiwara 1, Terashima M, Irinoda T, Takagane A, Abe K, Nakaya T, Yonezawa H, Oyama K, Takahashi M, Saito K, Takechi T, Fukushima M, Shirasaka T.  Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity.  Eur J Cancer  2003  39(16):2387-94  PubMed ID: 14556932   DOI: 10.1016/s0959-8049(03)00513-6
5936  Terashima M, Irinoda T, Kawamura H, Takagane A, Abe K, Oyama K, Fujiwara H, Saito K, Gotoh M, Shirasaka T.  Intermittent FLDP: 24-h infusion of 5-FU on days 1, 3 and 5 combined with low-dose cisplatin on days 1-5 for gastric cancer, and its pharmacologic and kinetic rationale.  Cancer Chemother Pharmacol  2003  51(3):240-6  PubMed ID: 12655443   DOI: 10.1007/s00280-003-0568-1
5940  Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga S, Hippo Y, Aburatani H, Funata N, Fukayama M.  Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection.  J Virol  2002  76(13):6825-31  PubMed ID: 12050395   DOI: 10.1128/jvi.76.13.6825-6831.2002
5941  Fujiwara H, Terashima M, Irinoda T, Takagane A, Abe K, Kashiwaba M, Oyama K, Takahashi M, Maesawa C, Saito K, Takechi T, Fukushima M.  Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR.  Jpn J Cancer Res  2002  93(12):1342-50  PubMed ID: 12495474   DOI: 10.1111/j.1349-7006.2002.tb01243.x
5944  Shinohara H, Morita S, Kawai M, Miyamoto A, Sonoda T, Pastan I, Tanigawa N.  Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin.  J Surg Res  2002  102(2):169-77  PubMed ID: 11796015   DOI: 10.1006/jsre.2001.6305
3772  Ijichi H, Ikenoue T, Kato N, Mitsuno Y, Togo G, Kato J, Kanai F, Shiratori Y, Omata M.  Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.  Biochem Biophys Res Commun  2001  289(2):350-7  PubMed ID: 11716479   DOI: 10.1006/bbrc.2001.5988
5950  Sato K, Sasaki K, Akiyama Y, Yamaguchi K.  Mass spectrometric high-throughput analysis of serum-free conditioned medium from cancer cell lines.  Cancer Lett  2001  170(2):153-9  PubMed ID: 11463493   DOI: 10.1016/s0304-3835(01)00567-5
5953  Matsumura M, Ijichi M, Shiratori Y, Togo G, Hikiba Y, Inoued K, Kohara M, Omata M.  Simple quantitative assay of alpha-fetoprotein mRNA in liver tissue using the real-time detection polymerase chain reaction assay - its application for clinical use.  Hepatol Res  2001  20(1):84-96  PubMed ID: 11282488   DOI: 10.1016/s1386-6346(00)00131-5
5957  Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S.  Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.  Br J Cancer  2001  84(9):1235-41  PubMed ID: 11336476   DOI: 10.1054/bjoc.2000.1735
5958  Sakakura C, Hagiwara A, Yasuoka R, Fujita Y, Nakanishi M, Masuda K, Shimomura K, Nakamura Y, Inazawa J, Abe T, Yamagishi H.  Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation.  Br J Cancer  2001  84(6):824-31  PubMed ID: 11259099   DOI: 10.1054/bjoc.2000.1684
15590  Kataoka H, Miura Y, Joh T, Seno K, Tada T, Tamaoki T, Nakabayashi H, Kawaguchi M, Asai K, Kato T, Itoh M.  Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1  Oncogene  2001  20(7):869-73  PubMed ID: 11314020   DOI: 10.1038/sj.onc.1204160
6160  Jawhari AU, Noda M, Farthing MJ, Pignatelli M.  Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines.  Br J Cancer  1999  80(3-4):322-30  PubMed ID: 10408833   DOI: 10.1038/sj.bjc.6690358
5971  Kataoka H, Joh T, Kasugai K, Okayama N, Moriyama A, Asai K, Kato T.  Expression of mRNA for heregulin and its receptor, ErbB-3 and ErbB-4, in human upper gastrointestinal mucosa.  Life Sci  1998  63(7):553-64  PubMed ID: 9718081   DOI: 10.1016/s0024-3205(98)00306-3
2194  Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R  Analysis of the DPC4 gene in gastric carcinoma  Jpn J Cancer Res  1997  88:335-339  PubMed ID: 9197522   DOI: 10.1111/j.1349-7006.1997.tb00385.x
5973  Tamura G, Sakata K, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R.  Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines.  Genes Chromosomes Cancer  1997  20(1):98-102  PubMed ID: 9290961  
2248  Koike N, Todoroki T, Komano H, Shimokama T, Ban S, Ohno T, Fukao K, Watanabe T.  Invasive potentials of gastric carcinoma cell lines: role of alpha 2 and alpha 6 integrins in invasion.  J Cancer Res Clin Oncol  1997  123(6):310-6  PubMed ID: 9222296   DOI: 10.1007/bf01438306



Back Back Return Top Page