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細胞番号 : 細胞名
RCB1001 : MKN45  update : 2024/06/17
細胞特性(Comment:英)Poorly differentiated gastric adenocarcinoma. Producing high level of CEA.
細胞特性(日)日本人胃癌細胞株で低分化型充実型腺癌由来。CEA高産生株。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Motoyama, Teiichi
樹立者 Hojo, Haruto
寄託日 1994
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Female
62 years
採取組織 stomach, liver meta
病名 Gastric adenocarcinoma
転移 Yes
転移巣 liver
細胞分類 cancer
初代培養日 1975
入手歴 Hojo, Haruto - Motoyama, Teiichi
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0434
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
動物種PCR OK
ウィルス(HIV) Lot.1 : (-)
ウィルス(HBV) Lot.1 : (-)
ウィルス(HCV) Lot.1 : (-)
染色体検査 40-44(50) : 40(1),41(1),42(7),43(36),44(5)
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 11件
Reference(日) 1件
利用者成果(英) 399件
利用者成果(日) 1件

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Reference(英)
4399  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921   DOI: 10.1111/j.1349-7006.2005.00133.x
4501  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123   DOI: 10.1158/1078-0432.ccr-03-0107
17278  Kim CH, Todoroki T, Matsumura M, Ohno T.  Eligibility of antigenic-peptide-pre-loaded and fixed adhesive peripheral blood cells for induction of cytotoxic T lymphocytes from cancer patients with elevated serum levels of carcinoembryonic antigen  J Cancer Res Clin Oncol  2000  126(7):383-90  PubMed ID: 10929760   DOI: 10.1007/pl00008486
4447  Ogose A, Motoyama T, Hotta T, Watanabe H.  Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells.  Pathol Int.   1996  46(1):9-14  PubMed ID: 10846544   DOI: 10.1111/j.1440-1827.1996.tb03527.x
11693  T Fujiwara, T Motoyama, N Ishihara, H Watanabe, T Kumanishi, K Kato, H Ichinose, T Nagatsu  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma  Int J Cancer  1993  54(6):965-71  PubMed ID: 8392984   DOI: 10.1002/ijc.2910540617
3128  Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res.  1991  82:1428-35  PubMed ID: 1778766   DOI: 10.1111/j.1349-7006.1991.tb01816.x
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682   DOI: 10.1111/j.1349-7006.1990.tb03332.x
3126  Yokoyama I, Watanabe T, Nishikimi M, Ichihashi H, Kondo T, Takagi H, Sakuma S  Radioimmunoscintigraphy of human gastric carcinoma xenografts with 125I-labeled monoclonal antibody.  Jpn J Cancer Res  1986  77:1114-21  PubMed ID: 3098721  
1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675   DOI: 10.1111/j.1440-1827.1986.tb01461.x
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141  

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Reference(日)
253  本山 悌一, 山本 尊彦, 佐藤 昭太郎  ヒト睾丸胎児性癌細胞の表面マーカー  日本泌尿器科學會雑誌  1985  76:74-80    DOI: 10.5980/jpnjurol1928.76.1_74

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利用者成果(英)
21538  Tang T, Zhao H, Shen S, Yang L, Lim CT.  Enhancing single-cell encapsulation in droplet microfluidics with fine-tunable on-chip sample enrichment.  Microsyst Nanoeng  2024  10:3  PubMed ID: 38169721   DOI: 10.1038/s41378-023-00631-y
21566  Lin H, Kobayashi M, Kushiro K, Yanagie H, Shimazoe K, Takahashi H.  In-vivo correlations of fluorescent or radioisotope glucose-analogs in imaging cancer metabolism.  Nucl Med Commun  2024    PubMed ID: 38247556   DOI: 10.1097/MNM.0000000000001812
21710  Makinoya M, Miyatani K, Matsumi Y, Sakano Y, Shimizu S, Shishido Y, Hanaki T, Kihara K, Matsunaga T, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Saito H, Nakayama Y, Osaki M, Okada F, Fujiwara Y.  Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.  Sci Rep  2024  14(1):10075  PubMed ID: 38698201   DOI: 10.1038/s41598-024-60967-x
21759  Cao Z, Hou Y, Zhao Z, Zhang H, Tian L, Zhang Y, Dong C, Guo F, Tan L, Han Y, Wang W, Jiao S, Tang Y, An L, Zhou Z.  Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity.  J Biol Chem  2024  300(6):107311  PubMed ID: 38657866   DOI: 10.1016/j.jbc.2024.107311
22091  Kume K, Iida M, Iwaya T, Yashima-Abo A, Koizumi Y, Endo A, Wade K, Hiraki H, Calvert V, Wulfkuhle J, Espina V, Siwak DR, Lu Y, Takemoto K, Suzuki Y, Sasaki Y, Tokino T, Petricoin E 3rd, Liotta LA, Mills GB, Nishizuka SS.  Targeted dynamic phospho-proteogenomic analysis of gastric cancer cells suggests host immunity provides survival benefit.  Mol Cell Proteomics  2024  100870  PubMed ID: 39461475   DOI: 10.1016/j.mcpro.2024.100870
22097  Fujimoto D, Kobayashi H.  PAR1 Is a Candidate Target for the Treatment of Peritoneal Dissemination in Gastric Cancer.  Anticancer Res  2024  44(11):4857-4867  PubMed ID: 39477325   DOI: 10.21873/anticanres.17311
22133  Shen Y, Zhong B, Zheng W, Wang D, Chen L, Song H, Pan X, Mo S, Jin B, Cui H, Zhan H, Luo F, Liu J.  Rg3-lipo biomimetic delivery of paclitaxel enhances targeting of tumors and myeloid-derived suppressor cells.  J Clin Invest  2024  134(22)  PubMed ID: 39545407   DOI: 10.1172/JCI178617
17785  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K.  Relationship between a deep learning model and liquid-based cytological processing techniques  Cytopathology  2023  Apr 13  PubMed ID: 37051774   DOI: 10.1111/cyt.13235
18073  Nor Azlin Safina Abdul Aziz, Maslinda Musa, Siti Hamimah Sheikh Abdul Kadir, Zeti Rahayu Abdul Karim, Narimah Abdul Hamid Hasani  Overexpression of Bactericidal/Permeability-Increasing Fold-Containing Family BPIFB1 in Gastric Cancer Cells Leads to Differential Expression of E-Cadherin and MUC5AC  Biology Bulletin  2023      DOI: 10.1134/s1062359022601756
19553  Fujino H, Sonoda-Fukuda E, Isoda L, Kawabe A, Takarada T, Kasahara N, Kubo S.  Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model  Int J Mol Sci  2023  24(19):14823  PubMed ID: 37834271   DOI: 10.3390/ijms241914823
19687  Mori Y, Nishikawa SG, Fratiloiu AR, Tsutsui M, Kataoka H, Joh T, Johnston RN.  Modulation of Reoviral Cytolysis (I): Combination Therapeutics  Viruses  2023  15(7):1472  PubMed ID: 37515160   DOI: 10.3390/v15071472
19708  Hachisu K, Tsuchida A, Takada Y, Mizuno M, Ideo H.  Galectin-4 Is Involved in the Structural Changes of Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer Cells with High Metastatic Potential  Int J Mol Sci  2023  24(15):12305  PubMed ID: 37569679   DOI: 10.3390/ijms241512305
19722  Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.  Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis  J Clin Invest  2023  133(18):e161847  PubMed ID: 37712427   DOI: 10.1172/JCI161847
19729  Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K.  ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer  Gastric Cancer  2023  26(3):379-392  PubMed ID: 36811690   DOI: 10.1007/s10120-023-01373-6
19939  hiozaki A, Fukami T, Shimizu H, Kosuga T, Kudou M, Takemoto K, Katsurahara K, Nishibeppu K, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Otsuji E.  Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer  Ann Surg Oncol  2023  30(13):8704-8716  PubMed ID: 37599296   DOI: 10.1245/s10434-023-14084-0
19962  Foscarini A, Tricarico R, Gentile F, Satam S, Mohr H, Kiss-Toth E, Ranzani GN, Pellegata NS.  Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2  Genes (Basel)  2023  15(1):26  PubMed ID: 38254916   DOI: 10.3390/genes15010026
21016  Zhu S, Al-Mathkour M, Cao L, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Hu T, McDonald OG, Zaika A, El-Rifai W.  CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis.  Cell Rep  2023  42(1):112005  PubMed ID: 36681899   DOI: 10.1016/j.celrep.2023.112005
21059  Hashimoto N, Kitai R, Fujita S, Yamauchi T, Isozaki M, Kikuta KI.  Single-Cell Analysis of Unidirectional Migration of Glioblastoma Cells Using a Fiber-Based Scaffold.  ACS Appl Bio Mater  2023    PubMed ID: 36758146   DOI: 10.1021/acsabm.2c00958
21229  Sihombing AM, Murata S, Shimoji M, Miyake T, Takebayashi K, Kodama H, Tokuda A, Kojima M, Ueki T, Kitamura N, Kitamura M, Mekata E, Tani M.  CD44-positive Cancer Stem-like Cells as a Potential Source of Peritoneal Metastasis After Surgery.  Anticancer Res  2023  43(6):2491-2500  PubMed ID: 37247920   DOI: 10.21873/anticanres.16416
21264  Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sudo K, Sato S, Ikeda K.  Effect of liquid-based cytology fixing solution on immunocytochemistry: Efficacy of antigen retrieval in cytologic specimens.  Diagn Cytopathol  2023    PubMed ID: 37329327   DOI: 10.1002/dc.25178
21269  Saito-Adachi M, Hama N, Totoki Y, Nakamura H, Arai Y, Hosoda F, Rokutan H, Yachida S, Kato M, Fukagawa A, Shibata T.  Oncogenic structural aberration landscape in gastric cancer genomes.  Nat Commun  2023  14(1):3688  PubMed ID: 37349325   DOI: 10.1038/s41467-023-39263-1
21486  Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H.  Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.  Ann Surg Oncol  2023    PubMed ID: 38006530   DOI: 10.1245/s10434-023-14586-x
21559  Soutto M, Zhang X, Bhat N, Chen Z, Zhu S, Maacha S, Genoula M, El-Gazzaz O, Peng D, Lu H, McDonald OG, Chen XS, Cao L, Xu Z, El-Rifai W.  Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis.  Redox Biol  2023  69:102998  PubMed ID: 38154380   DOI: 10.1016/j.redox.2023.102998
17553  Koike K, Masuda T, Sato K, Fujii A, Wakiyama H, Tobo T, Takahashi J, Motomura Y, Nakano T, Saito H, Matsumoto Y, Otsu H, Takeishi K, Yonemura Y, Mimori K, Nakagawa T.  GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein  Cancer Sci  2022  113(1):156-169  PubMed ID: 34704338   DOI: 10.1111/cas.15174
17567  Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer  Cancer Sci  2022  113(6):1984-1998  PubMed ID: 35307915   DOI: 10.1111/cas.15342
17575  Inhibition of EP2 receptor suppresses tumor growth and chemoresistance of gastric cancer  Inhibition of EP2 receptor suppresses tumor growth and chemoresistance of gastric cancer  Am J Cancer Res  2022  12(10):4680-4692  PubMed ID: 36381319  
17617  Cao L, Zhu S, Lu H, Soutto M, Bhat N, Chen Z, Peng D, Lin J, Lu J, Li P, Zheng C, Huang C, El-Rifai W.  Helicobacter pylori-induced RASAL2 Through Activation of Nuclear Factor-κB Promotes Gastric Tumorigenesis via β-catenin Signaling Axis  Gastroenterology  2022  162(6):1716-1731.e17  PubMed ID: 35134322   DOI: 10.1053/j.gastro.2022.01.046
18828  Iwamuro M, Shiraha H, Kobashi M, Horiguchi S, Okada H.  Laminin 511-E8 Fragment Offers Superior Adhesion Properties for Gastric Cancer Cells Compared with Full-Length Laminin 511  Curr Issues Mol Biol  2022  44(4):1539-1551  PubMed ID: 35723363   DOI: 10.3390/cimb44040105
20316  Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N, Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K, Tashiro H.  Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.  J Gastrointest Surg  2022    PubMed ID: 34379296   DOI: 10.1007/s11605-021-05101-2
20377  Khalafi S, Zhu S, Khurana R, Lohse I, Giordano S, Corso S, Al-Ali H, Brothers SP, Wahlestedt C, Schürer S, El-Rifai W.  A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer.  Transl Oncol  2022  15(1):101260  PubMed ID: 34735897   DOI: 10.1016/j.tranon.2021.101260
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20476  Ando-Matsuoka R, Ando H, Abu Lila AS, Maeda N, Shimizu T, Ishima Y, Ishida T.  I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors.  J Control Release  2022    PubMed ID: 34896447   DOI: 10.1016/j.jconrel.2021.12.004
20571  Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.  Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.  Gastric Cancer  2022    PubMed ID: 35166958   DOI: 10.1007/s10120-022-01283-z
20600  Xie J, Fu L, Zhang J.  Analysis of Influencing Factors on the Occurrence and Development of Gastric Cancer in High-Incidence Areas of Digestive Tract Tumors Based on High Methylation of GPX3 Gene.  J Oncol  2022  3094881  PubMed ID: 35069731   DOI: 10.1155/2022/3094881
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
20664  Han Y, Dong Q, Liu T, Chen X, Yu C, Zhang Y.  The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.  Biochem Biophys Res Commun  2022  610:1-7  PubMed ID: 35461070   DOI: 10.1016/j.bbrc.2022.04.029
20688  Watanabe T, Nishio Y, Yamamoto Y, Shimizu T, Li XK, Okita H, Kuroda T.  Photodynamic therapy with 5-aminolevulinic acid: A new diagnostic, therapeutic, and surgical aid for neuroblastoma.  J Pediatr Surg  2022    PubMed ID: 35396087   DOI: 10.1016/j.jpedsurg.2022.02.028
16894  Kimura Y, Ohzawa H, Miyato H, Kaneko Y, Saito A, Takahashi K, Tojo M, Yamaguchi H, Kurashina K, Saito S, Hosoya Y, Lefor AK, Sata N, Kitayama J.  MiR-29b may suppresses peritoneal metastases through inhibition of the mesothelial-mesenchymal transition (MMT) of human peritoneal mesothelial cells  Sci Rep  2022  12(1):205  PubMed ID: 34997082   DOI: 10.1038/s41598-021-04065-2
20825  Wang Q, Chen C, Xu X, Shu C, Cao C, Wang Z, Fu Y, Xu L, Xu K, Xu J, Xia A, Wang B, Xu G, Zou X, Su R, Kang W, Xue Y, Mo R, Sun B, Wang S.  APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.  Adv Sci (Weinh)  2022  e2201889  PubMed ID: 35975461   DOI: 10.1002/advs.202201889
16979  Ma J, Zhang C, Liang W, Li L, Du J, Pan C, Chen B, Chen Y, Wang Y.  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  Front Oncol  2022  12:802009  PubMed ID: 35251974   DOI: 10.3389/fonc.2022.802009
20887  Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W.  MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.  Theranostics  2022  12(15):6509-6526  PubMed ID: 36185598   DOI: 10.7150/thno.75431
20953  Sugezawa K, Morimoto M, Yamamoto M, Matsumi Y, Nakayama Y, Hara K, Uejima C, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Umekita Y, Fujiwara Y.  GPX4 Regulates Tumor Cell Proliferation via Suppressing Ferroptosis and Exhibits Prognostic Significance in Gastric Cancer.  Anticancer Res  2022  42(12):5719-5729  PubMed ID: 36456115   DOI: 10.21873/anticanres.16079
21996  Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Morinaga Y, Konishi E, Otsuji E.  Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer  World J Gastroenterol  2022  28(32):4649-4667.  PubMed ID: 36157935   DOI: 10.3748/wjg.v28.i32.4649
18099  Kato T, Nakamori M, Matsumura S, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H.  Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer  Oncol Lett  2021  21(6):490  PubMed ID: 33968206   DOI: 10.3892/ol.2021.12751
13245  Hasegawa K, Fujii S, Matsumoto S, Tajiri Y, Kikuchi A, Kiyoshima T.  YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation.  J Pathol  2021    PubMed ID: 32985688   DOI: 10.1002/path.5553
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
13361  Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T.  Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.  Fitoterapia  2021    PubMed ID: 33246033   DOI: 10.1016/j.fitote.2020.104780
20036  Akagi S, Ando H, Fujita K, Shimizu T, Ishima Y, Tajima K, Matsushima T, Kusano T, Ishida T.  Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model.  Int J Biol Macromol  2021  174:494-501  PubMed ID: 33545180   DOI: 10.1016/j.ijbiomac.2021.01.201
20061  Iwamuro M, Shiraha H, Oyama A, Uchida D, Horiguchi S, Okada H.  Laminin-411 and -511 Modulate the Proliferation, Adhesion, and Morphology of Gastric Cancer Cells.  Cell Biochem Biophys  2021    PubMed ID: 33629255   DOI: 10.1007/s12013-021-00972-3
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
14292  Hernández C, Toledo-Stuardo K, García-González P, Garrido-Tapia M, Kramm K, Rodríguez-Siza JA, Hermoso M, Ribeiro CH, Molina MC.  Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4  Helicobacter  2021  e12812  PubMed ID: 33928707   DOI: 10.1111/hel.12812
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
20224  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E.  Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer.  Photodiagnosis Photodyn Ther  2021    PubMed ID: 34242818   DOI: 10.1016/j.pdpdt.2021.102420
20385  Ito K, Kitajima Y, Kai K, Matsufuji S, Yamada K, Egawa N, Kitagawa H, Okuyama K, Tanaka T, Noshiro H.  Matrix metalloproteinase‑1 expression is regulated by HIF‑1‑dependent and epigenetic mechanisms and serves a tumor‑suppressive role in gastric cancer progression.  Int J Oncol  2021  59(6)  PubMed ID: 34738626   DOI: 10.3892/ijo.2021.5282
20415  Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T.  Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.  Oncol Lett  2021  22(4):735  PubMed ID: 34466148   DOI: 10.3892/ol.2021.12996
20421  Reyna-Jeldes M, De la Fuente-Ortega E, Cerda D, Velázquez-Miranda E, Pinto K, Vázquez-Cuevas FG, Coddou C.  Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines.  Pharmaceutics  2021  13(8)  PubMed ID: 34452195   DOI: 10.3390/pharmaceutics13081234
20520  Komatsu S, Imamura T, Kiuchi J, Takashima Y, Kamiya H, Ohashi T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer.  Am J Cancer Res  2021  11(12):6133-6146  PubMed ID: 35018247  
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
16803  Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H.  Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells  FEBS Open Bio  2021  11(5):1465-1475  PubMed ID: 33773069   DOI: 10.1002/2211-5463.13154
18207  Shigematsu N, Kawashiri T, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T.  Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro  Sci Rep  2020  10(1):6734  PubMed ID: 32317735   DOI: 10.1038/s41598-020-62738-w
11630  Nishimura T, Mitsunaga M, Ito K, Kobayashi H, Saruta M.  Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT.  Gastric Cancer  2020  23(1):82-94  PubMed ID: 31302791   DOI: 10.1007/s10120-019-00988-y
12041  Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S.  FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.  Oncogenesis  2020    PubMed ID: 32029704   DOI: 10.1038/s41389-020-0190-7
13071  Tiffon C, Giraud J, Molina-Castro SE, Peru S, Seeneevassen L, Sifré E, Staedel C, Bessède E, Dubus P, Mégraud F, Lehours P, Martin OCB, Varon C.  TAZ Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties.  Cells  2020    PubMed ID: 32545795   DOI: 10.3390/cells9061462
13242  Uejima C, Morimoto M, Yamamoto M, Hara K, Miyauchi W, Sugezawa K, Tada Y, Tanio A, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y.  Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer.  Anticancer Res  2020  40(10):5593-5600  PubMed ID: 32988883   DOI: 10.21873/anticanres.14572
13299  Wang J, Li Q, Cheng X, Zhang B, Lin J, Tang Y, Li F, Yang CS, Wang TC, Tu S.  Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop.  Onco Targets Ther  2020    PubMed ID: 33116635   DOI: 10.2147/OTT.S266506
13504  Baatar S, Bai T, Yokobori T, Gombodorj N, Nakazawa N, Ubukata Y, Kimura A, Kogure N, Sano A, Sohda M, Sakai M, Tumenjargal A, Ogata K, Kuwano H, Shirabe K, Saeki H.  High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer  Ann Surg Oncol  2020  27(11):4360-4368  PubMed ID: 32356270   DOI: 10.1245/s10434-020-08518-2
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
13838  He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S.  MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression  FASEB J  2020  34(6):8544-8557  PubMed ID: 32356314   DOI: 10.1096/fj.201903217R
14297  Kumagai Y, Ohzawa H, Miyato H, Horie H, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Surgical Stress Increases Circulating Low-Density Neutrophils Which May Promote Tumor Recurrence  J Surg Res  2020  246:52-61  PubMed ID: 31561178   DOI: 10.1016/j.jss.2019.08.022
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14844  Zhu S, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Que J, Garcia-Buitrago M, Zaika A, El-Rifai W.  Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib  Cancer Lett  2020  491:87-96  PubMed ID: 32735911   DOI: 10.1016/j.canlet.2020.07.014
14847  Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T.  Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance  Cancer Res  2020  80(16):3222-3235  PubMed ID: 32605995   DOI: 10.1158/0008-5472.CAN-19-3803
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11360  Futami K, Kimoto M, Lim YWS, Hirao I.  Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells.  Mol Ther Nucleic Acids  2019    PubMed ID: 30594072   DOI: 10.1016/j.omtn.2018.11.011
11409  Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M.  NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells.  Oncogene  2019    PubMed ID: 30700829   DOI: 10.1038/s41388-019-0702-0
11448  Kim JH, Eom HJ, Lim G, Park S, Lee J, Nam S, Kim YH, Jeong JH.  Differential effects, on oncogenic pathway signalling, by derivatives of the HNF4 α inhibitor BI6015.  Br. J. Cancer  2019    PubMed ID: 30792535   DOI: 10.1038/s41416-018-0374-5
11456  Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H.  Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.  Sci Rep  2019    PubMed ID: 30808977   DOI: 10.1038/s41598-019-39563-x
6418  Hevia MJ, Castro P, Pinto K1, Reyna-Jeldes M, Rodríguez-Tirado F, Robles-Planells C, Ramírez-Rivera S, Madariaga JA, Gutierrez F, López J, Barra M, De la Fuente-Ortega E, Bernal G, Coddou C.  Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors.  Front Pharmacol  2019  10:612  PubMed ID: 31249523   DOI: 10.3389/fphar.2019.00612
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11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217   DOI: 10.1016/j.bbrep.2019.100632
11527  Ando H, Abu Lila AS, Fukushima M, Matsuoka R, Shimizu T, Okuhira K, Ishima Y, Huang CL, Wada H, Ishida T.  A simplified method for manufacturing RNAi therapeutics for local administration.  Int J Pharm  2019    PubMed ID: 31015002   DOI: 10.1016/j.ijpharm.2019.04.054
11613  Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W.  Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.  Oncogene  2019  38(29):5805-5816  PubMed ID: 31235784   DOI: 10.1038/s41388-019-0843-1
11695  Shunsuke Odai, Hidehiro Ito, Toshiaki Kamachi  Dendrimer porphyrins as the oxygen sensor for intracellular imaging to suppress interaction towards biological molecules  Journal of Clinical Biochemistry and Nutrition  2019    PubMed ID: 31777418   DOI: 10.3164/jcbn.19-13
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11850  Ando H, Fukushima M, Eshima K, Hasui T, Shimizu T, Ishima Y, Huang CL, Wada H, Ishida T.  A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model.  Cancer Med  2019    PubMed ID: 31609087   DOI: 10.1002/cam4.2598
6888  Nakayama T, Kobayashi T, Shimpei O, Fukuhara H, Namikawa T, Inoue K, Hanazaki K, Takahashi K, Nakajima M, Tanaka T, Ogura SI.  Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway.  Photodiagnosis Photodyn Ther  2019  28:10-17  PubMed ID: 31404677   DOI: 10.1016/j.pdpdt.2019.07.021
10444  Yuta Sugiyama, Erika Takahashi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura  Inverse correlation between heme synthesis and the Warburg effect in cancer cells  bioRxiv  2019  August 30    DOI: 10.1101/753079
11904  Gomaa A, Peng D, Chen Z, Soutto M, Abouelezz K, Corvalan A, El-Rifai W.  Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers.  Sci Rep  2019    PubMed ID: 31740746   DOI: 10.1038/s41598-019-53174-6
11969  Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S.  Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma.  Sci Rep  2019    PubMed ID: 31873082   DOI: 10.1038/s41598-019-55465-4
12422  Miyagi A, Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents  Biol Pharm Bull  2019  42(4):638-644.  PubMed ID: 30930422   DOI: 10.1248/bpb.b18-00855
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12424  Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect  J Pharmacol Sci  2019  140(3):291-294  PubMed ID: 31377017   DOI: 10.1016/j.jphs.2019.05.009
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10744  Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang LJ, Chen SJ.  HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells.  Gastric Cancer  2018  21(5):756-764  PubMed ID: 29417297   DOI: 10.1007/s10120-018-0801-6
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007   DOI: 10.1038/s41416-018-0008-y
10831  Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T.  A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.  Biol. Pharm. Bull.  2018  41:733-742  PubMed ID: 29709910   DOI: 10.1248/bpb.b17-00919
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11210  Nguyen PH, Touchefeu Y, Durand T, Aubert P, Duchalais E, Bruley des Varannes S, Varon C, Neunlist M, Matysiak-Budnik T.  Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type.  Tumour Biol.  2018    PubMed ID: 30207200   DOI: 10.1177/1010428318799028
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11219  Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H.  Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.  Oncol Lett  2018    PubMed ID: 30250614   DOI: 10.3892/ol.2018.9301
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
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10253  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433   DOI: 10.3892/ol.2017.5987
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10328  Suzuki N, Nakagawa F, Takechi T.  Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.  Oncol Lett  2017  14:639-646  PubMed ID: 28693216   DOI: 10.3892/ol.2017.6258
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175   DOI: 10.3892/or.2017.5844
10486  Shibaguchi H, Luo N, Shirasu N, Kuroki M, Kuroki M.  Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen.  Onco Targets Ther  2017  10:3979-3990  PubMed ID: 28860806   DOI: 10.2147/OTT.S140174
10652  Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S.  Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F.  Oncotarget  2017  8:97371-97383  PubMed ID: 29228617   DOI: 10.18632/oncotarget.22126
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969   DOI: 10.18632/oncotarget.20860
10722  Lan KH, Lee WP, Wang YS, Liao SX, Lan KH.  Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells.  Oncotarget  2017  8:113460-113471  PubMed ID: 29371922   DOI: 10.18632/oncotarget.23050
10955  Kitayama J, Ishigami H, Yamaguchi H, Yamada J, Soma D, Miyato H, Kamei T, Lefor AK, Sata N.  Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model  Pleura Peritoneum  2017  2:95-102  PubMed ID: 30911637   DOI: 10.1515/pp-2017-0002
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5806  Shiroki T et al  Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.  Cancer Sci  2017  108(5):931-940  PubMed ID: 28235245   DOI: 10.1111/cas.13211
13680  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Proliferation and motility of hepatocellular, pancreatic and gastric cancer cells grown in a medium without glucose and arginine, but with galactose and ornithine  Oncol Lett  2017  13(3):1276-1280  PubMed ID: 28454246   DOI: 10.3892/ol.2017.5568
14097  Kimura A, Ogata K, Altan B, Yokobori T, Mochiki E, Yanai M, Kogure N, Yanoma T, Suzuki M, Bai T, Kuwano H.  Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis  World J Gastroenterol  2017  23(42):7541-7550  PubMed ID: 29204054   DOI: 10.3748/wjg.v23.i42.7541
14358  Garrido-Tapia M, Hernández CJ, Ascui G, Kramm K, Morales M, Ga Rate V, Zúñiga R, Bustamante M, Aguillón JC, Catala N D, Ribeiro CH, Molina MAC.  STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells  Immunobiology  2017  222(11):1043-1051  PubMed ID: 28578917   DOI: 10.1016/j.imbio.2017.05.009
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14619  Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E.  Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer  Oncotarget  2017  8(60):101394-101405  PubMed ID: 29254173   DOI: 10.18632/oncotarget.20736
14663  Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M, Nakajima Y.  Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer  Oncol Lett  2017  13(5):3131-3138  PubMed ID: 28521418   DOI: 10.3892/ol.2017.5806
14735  Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS.  Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil  Sci Rep  2017  7(1):2262  PubMed ID: 28536445   DOI: 10.1038/s41598-017-02548-9
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
14746  Chen Z, Hu T, Zhu S, Mukaisho K, El-Rifai W, Peng DF.  Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer  Oncotarget  2017  8(33):54345-54356  PubMed ID: 28903346   DOI: 10.18632/oncotarget.17527
14747  Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jiménez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, Graham DY, Yamaoka Y.  Interleukin-17C in Human Helicobacter pylori Gastritis  Infect Immun  2017  85(10):e00389-17  PubMed ID: 28739826   DOI: 10.1128/IAI.00389-17
7297  Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W.  Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.  Oncogene  2016  35:1847-56  PubMed ID: 26119931   DOI: 10.1038/onc.2015.250
9517  Lin CJ, Liao WC, Lin HJ, Hsu YM, Lin CL, Chen YA, Feng CL, Chen CJ, Kao MC, Lai CH, Kao CH.  Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies.  PLoS ONE  2016  11:e0146432  PubMed ID: 26730715   DOI: 10.1371/journal.pone.0146432
9541  Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H.  Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.  BMC Cancer  2016  16:37  PubMed ID: 26810644   DOI: 10.1186/s12885-016-2072-0
9542  Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.  Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia.  Int. J. Oncol.  2016  48:1379-90  PubMed ID: 26820502   DOI: 10.3892/ijo.2016.3359
9548  Mu J, Liu T, Jiang L, Wu X, Cao Y, Li M, Dong Q, Liu Y, Xu H.  The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells.  J Cancer  2016  7:453-61  PubMed ID: 26918059   DOI: 10.7150/jca.13548
9625  Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K.  Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.  J. Gastroenterol.  2016  51:1101-1111  PubMed ID: 27002316   DOI: 10.1007/s00535-016-1197-x
9652  Lan H, Tang Z, Jin H, Sun Y.  Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.  Sci Rep  2016  6:24218  PubMed ID: 27063292   DOI: 10.1038/srep24218
9672  Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP.  Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.  Oncogene  2016  35:5388-5399  PubMed ID: 27109105   DOI: 10.1038/onc.2016.76
9760  Zhou J, You W, Sun G, Li Y, Chen B, Ai J, Jiang H.  The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis.  J. Pharmacol. Exp. Ther.  2016  359:54-61  PubMed ID: 27432893   DOI: 10.1124/jpet.116.234799
9795  Xie P, Fujii I, Zhao J, Shinohara M, Matsukura M.  A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.  Int. J. Oncol.  2016  49:1561-1568  PubMed ID: 27633119   DOI: 10.3892/ijo.2016.3658
9902  Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T.  Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer.  Anticancer Res.  2016  36:6005-6009  PubMed ID: 27793927   DOI: 10.21873/anticanres.11189
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9928  Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:E7535-E7544  PubMed ID: 27821766   DOI: 10.1073/pnas.1608585113
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5808  Hughes PE et al  In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.  Mol Cancer Ther  2016  15(7):1568-79  PubMed ID: 27196782   DOI: 10.1158/1535-7163.MCT-15-0871
5809  Ninomiya K et al  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  J Nat Med   2016  70(3):435-51  PubMed ID: 27178360   DOI: 10.1007/s11418-016-0998-9
5810  Kitagawa N et al  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.  Int J Mol Sci  2016  17(12). pii: E1979  PubMed ID: 27898032   DOI: 10.3390/ijms17121979
5813  Costa AM etal  Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.  J Infect Dis  2016  213(11):1767-76  PubMed ID: 26802142   DOI: 10.1093/infdis/jiw031
12613  Takeda S, Tanigawa T, Watanabe T, Tatsuwaki H, Nadatani Y, Otani K, Nagami Y, Tanaka F, Kamata N, Yamagami H, Shiba M, Tominaga K, Fujiwara Y, Muguruma K, Ohira M, Hirakawa K, Arakawa T.  Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma  J Gastroenterol Hepatol  2016  31(2):376-83  PubMed ID: 26250887   DOI: 10.1111/jgh.13079
12633  Hu W, Zhang Y, Jiang Z, Wang L, Li J, Chen S, Dai N, Si J.  The tumor promoting roles of erythropoietin/erythropoietin receptor signaling pathway in gastric cancer  Tumour Biol  2016  ;37(8):11523-33  PubMed ID: 27086036   DOI: 10.1007/s13277-016-5053-7
12656  Kitayama J, Yamaguchi H, Ishigami H, Matsuzaki K, Sata N.  Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells  PLoS One  2016  11(5):e0154542  PubMed ID: 27136922   DOI: 10.1371/journal.pone.0154542
12873  Liu X, Kwong A, Sihoe A, Chu KM.  Plasma miR-940 may serve as a novel biomarker for gastric cancer  Tumour Biol  2016  37(3):3589-97  PubMed ID: 26456959   DOI: 10.1007/s13277-015-4019-5
12874  Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H.  Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients  Gastric Cancer  2016  19(3):789-97.  PubMed ID: 26472729   DOI: 10.1007/s10120-015-0551-7
12913  Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E.  Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells  Oncotarget  2016  7(35):56855-56863  PubMed ID: 27487135   DOI: 10.18632/oncotarget.10869
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
12966  Tseng PC, Chen CL, Shan YS, Lin CF.  An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells  Oncotarget  2016  7(12):15150-60  PubMed ID: 26934444   DOI: 10.18632/oncotarget.7750
12968  Kimura A, Ogata K, Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Yanoma T, Suzuki M, Bai T, Oyama T, Kuwano H.  Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer  Oncotarget  2016  7(14):18415-23  PubMed ID: 26943774   DOI: 10.18632/oncotarget.7821
13474  Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.  α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15  Sci Rep  2016  6:25895  PubMed ID: 27181033   DOI: 10.1038/srep25895
14008  Thura M, Al-Aidaroos AQO, Yong WP, Kono K, Gupta A, Lin YB, Mimura K, Thiery JP, Goh BC, Tan P, Soo R, Hong CW, Wang L, Lin SJ, Chen E, Rha SY, Chung HC, Li J, Nandi S, Yuen HF, Zhang SD, Guan YK, So J, Zeng Q.  PRL3-zumab, a first-in-class humanized antibody for cancer therapy  JCI Insight  2016  1(9):e87607  PubMed ID: 27699276   DOI: 10.1172/jci.insight.87607
14159  Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR.  CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions  Cancer Discov  2016  ;6(8):900-13  PubMed ID: 27260157   DOI: 10.1158/2159-8290.CD-16-0178
14577  Sougleri IS, Papadakos KS, Zadik MP, Mavri-Vavagianni M, Mentis AF, Sgouras DN.  Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner  FEBS J  2016  283(2):206-20  PubMed ID: 26907789   DOI: 10.1111/febs.13592
17834  Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T.  High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime  Sci Rep   2015  5:10657  PubMed ID: 26065366   DOI: 10.1038/srep10657
7097  Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566   DOI: 10.1371/journal.pone.0146026
7206  Sawamura T, Tanaka T, Ishige H, Iizuka M, Murayama Y, Otsuji E, Ohkubo A, Ogura S, Yuasa H.  The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency.  Int J Mol Sci  2015  16:22415-24  PubMed ID: 26389895   DOI: 10.3390/ijms160922415
7233  Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.  Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.  Sci Rep  2015  5:13474  PubMed ID: 26310847   DOI: 10.1038/srep13474
7277  Yoshimoto M, Higaki K, Nanba E, Ikeguchi M.  Anti-Proliferation Activity of Fucoidan in MKN45 Gastric Cancer Cells and Downregulation of Phosphorylated ASK1, a Cell Cycle-Regulated Kinase.  Yonago Acta Med  2015  58:1-7  PubMed ID: 26190891  
7334  Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H.  Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.  Sci Rep  2015  5:10455  PubMed ID: 25994878   DOI: 10.1038/srep10455
7470  Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K.  The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.  Ann. Surg. Oncol.  2015  22 Suppl 3:S1436-43  PubMed ID: 25707493   DOI: 10.1245/s10434-015-4418-2
7512  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA.  Int. J. Oncol.  2015  46:1018-24  PubMed ID: 25586465   DOI: 10.3892/ijo.2015.2830
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5819  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.  CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.  Cancer Med  2015  4(9):1322-33  PubMed ID: 26077800   DOI: 10.1002/cam4.478
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13701  Fujimoto D, Ueda Y, Hirono Y, Goi T, Yamaguchi A.  PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway  Oncotarget  2015  6(33):34788-99  PubMed ID: 26431277   DOI: 10.18632/oncotarget.5858
13728  Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Hiraki S, Horiguchi H, Miyazaki H, Ono S, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K.  Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer  Ann Surg Oncol  2015  22 Suppl 3:S923-8  PubMed ID: 25986868   DOI: 10.1245/s10434-015-4594-0
14977  Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y.  CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence  J Surg Oncol  2015  112(6):622-8  PubMed ID: 26416034   DOI: 10.1002/jso.24056
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15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
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18179  Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.  Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses  Elife  2014  3:e04177  PubMed ID: 25149452   DOI: 10.7554/eLife.04177
18932  Kang W, Tong JH, Chan AW, Zhao J, Dong Y, Wang S, Yang W, Sin FM, Ng SS, Yu J, Cheng AS, To KF.  Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma  J Transl Med  2014  12:80  PubMed ID: 24674326   DOI: 10.1186/1479-5876-12-80
18949  Murai T, Yamada S, Fuchs BC, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Tanabe KK, Kodera Y.  Epithelial-to-mesenchymal transition predicts prognosis in clinical gastric cancer  J Surg Oncol  2014  109(7):684-9  PubMed ID: 24453058   DOI: 10.1002/jso.23564
19060  Tawada M, Hayashi S, Ikegame Y, Nakashima S, Yoshida K.  Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow  Oncol Rep  2014  32(6):2359-64  PubMed ID: 25242215   DOI: 10.3892/or.2014.3499
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5823  Yoneda A, Taniguchi K, Torashima Y, Susumu S, Kanetaka K, Kuroki T, Eguchi S.  The detection of gastric cancer cells in intraoperative peritoneal lavage using the reverse transcription--loop-mediated isothermal amplification method.  J Surg Res  2014  187(1):e1-6  PubMed ID: 24360119   DOI: 10.1016/j.jss.2013.01.001
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5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286   DOI: 10.1371/journal.pone.0102831
5832  Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, Kan S, Li Z, Zhang X, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration.  Br J Cancer  2014  110(7):1801-10  PubMed ID: 24548863   DOI: 10.1038/bjc.2014.70
6398  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629   DOI: 10.1016/j.bbrc.2014.06.007
14396  Zhang Z, Miao L, Wu X, Liu G, Peng Y, Xin X, Jiao B, Kong X.  Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling  J Cancer  2014  5(5):382-9  PubMed ID: 24799956   DOI: 10.7150/jca.8024
15817  Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G.  A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines  PLoS One  2014  9(2):e90155  PubMed ID: 24587255   DOI: 10.1371/journal.pone.0090155
15826  Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Watanabe T.  CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment  PLoS One  2014  9(1):e86516  PubMed ID: 24466130   DOI: 10.1371/journal.pone.0086516
15903  Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T.  Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin  Cancer Biol Ther  2014  15(1):81-8  PubMed ID: 24149371   DOI: 10.4161/cbt.26610
15904  E Montiel-Eulefi, F Jara, C Toro, M Garcés, P Leal  Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4 Loaded PLA Nanoparticles on MKN-45 Gastric Adenocarcinoma Cell Line  International Journal of Morphology  2014  32:61-69    DOI: 10.4067/s0717-95022014000100011
15998  Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Horiguchi H, Hiraki S, Ono S, Miyazaki H, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K.  Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer  Cancer Sci   2014  105(12):1626-30  PubMed ID: 25287817   DOI: 10.1111/cas.12553
16650  Otsuki T, Fujimoto D, Hirono Y, Goi T, Yamaguchi A.  Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer  Int J Oncol  2014  45(6):2287-94  PubMed ID: 25231630   DOI: 10.3892/ijo.2014.2651
17126  Migita K, Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Ito M, Nishiwada S, Nakajima Y.  Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer  Gastric Cancer  2014  17(4):601-9  PubMed ID: 24292229   DOI: 10.1007/s10120-013-0318-y
18277  Funakoshi Y, Mukohara T, Tomioka H, Ekyalongo RC, Kataoka Y, Inui Y, Kawamori Y, Toyoda M, Kiyota N, Fujiwara Y, Minami H.  Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line  Invest New Drugs  2013  31(5):1158-68  PubMed ID: 23568717   DOI: 10.1007/s10637-013-9959-2
18600  Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A.  The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion  Int J Oncol  2013  42(2):565-73  PubMed ID: 23242308   DOI: 10.3892/ijo.2012.1738
18959  Okada K, Fujiwara Y, Takahashi T, Nakamura Y, Takiguchi S, Nakajima K, Miyata H, Yamasaki M, Kurokawa Y, Mori M, Doki Y.  Overexpression of forkhead box M1 transcription factor (FOXM1) is a potential prognostic marker and enhances chemoresistance for docetaxel in gastric cancer  Ann Surg Oncol  2013  20(3):1035-43  PubMed ID: 23054116   DOI: 10.1245/s10434-012-2680-0
19053  Mimura K, Shiraishi K, Mueller A, Izawa S, Kua LF, So J, Yong WP, Fujii H, Seliger B, Kiessling R, Kono K.  The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer  J Immunol  2013  191(12):6261-72  PubMed ID: 24244023   DOI: 10.4049/jimmunol.1301597
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5835  Funakoshi Y, Mukohara T, Ekyalongo RC, Tomioka H, Kataoka Y, Shimono Y, Chayahara N, Toyoda M, Kiyota N, Fujiwara Y, Minami H.  Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.  Oncol Res. 2  2013  21(6):287-93  PubMed ID: 25198658   DOI: 10.3727/096504014X13946388748956
5839  Ikawa-Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, Ida S, Tokunaga E, Kitao H, Morita M, Maehara Y.  Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells.  Cancer Med  2013  2(4):447-56  PubMed ID: 24156017   DOI: 10.1002/cam4.101
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5842  Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, Li Z, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.  Carcinogenesis  2013  34(5):974-83  PubMed ID: 23354307   DOI: 10.1093/carcin/bgt028
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9102  Toshiaki Tsuji, Mikihito Nakamori, Makoto Iwahashi, Masaki Nakamura, Toshiyasu Ojima, Takeshi Iida, Masahiro Katsuda, Keiji Hayata, Yasushi Ino, Tomoki Todo, Hiroki Yamaue  An Armed Oncolytic Herpes Simplex Virus Expressing thrombospondin-1 Has an Enhanced in Vivo Antitumor Effect Against Human Gastric Cancer  Int J Cancer  2013  132 (2), 485-94  PubMed ID: 22729516   DOI: 10.1002/ijc.27681
14202  Navabi N, McGuckin MA, Lindén SK.  Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation  PLoS One  2013  8(7):e68761  PubMed ID: 23869232   DOI: 10.1371/journal.pone.0068761
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17166  Tao Y, Guo Y, Liu W, Zhang J, Li X, Shen L, Ru Y, Xue Y, Zheng J, Liu X, Zhang J, Yao L.  AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells  Braz J Med Biol Res  2013  46(4):394-40  PubMed ID: 23558861   DOI: 10.1590/1414-431x20122211
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5849  Tu SP, Jin H, Shi JD, Zhu LM, Suo Y, Lu G, Liu A, Wang TC, Yang CS.  Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth.  Cancer Prev Res (Phila)  2012  5(2):205-15  PubMed ID: 22030090   DOI: 10.1158/1940-6207.CAPR-11-0247
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8439  Zhang DX, Zhao PT, Xia L, Liu LL, Liang J, Zhai HH, Zhang HB, Guo XG, Wu KC, Xu YM, Jia LT, Yang AG, Chen SY, Fan DM.  Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.  Gut  2010  59:292-9  PubMed ID: 19951902   DOI: 10.1136/gut.2008.155226
18757  Kawaguchi K, Etoh T, Suzuki K, Mitui MT, Nishizono A, Shiraishi N, Kitano S.  Efficacy of oncolytic reovirus against human gastric cancer with peritoneal metastasis in experimental animal model  Int J Oncol  2010  37(6):1433-8  PubMed ID: 21042711   DOI: 10.3892/ijo_00000795
18967  Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A.  The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion  BMC Cancer  2010  10:443  PubMed ID: 20723226   DOI: 10.1186/1471-2407-10-443
19089  Komiyama H, Aoki A, Tanaka S, Maekawa H, Kato Y, Wada R, Maekawa T, Tamura M, Shiroishi T.  Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)  Genes Genet Syst  2010  85(1):75-83  PubMed ID: 20410667   DOI: 10.1266/ggs.85.75
5868  Tsunemi S, Nakanishi T, Fujita Y, Bouras G, Miyamoto Y, Miyamoto A, Nomura E, Takubo T, Tanigawa N.  Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.  Oncol Rep  2010  23(4):949-56  PubMed ID: 20204278   DOI: 10.3892/or_00000719
8457  Zaidi SF, Yamamoto T, Refaat A, Ahmed K, Sakurai H, Saiki I, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.  Helicobacter  2009  14:588-95  PubMed ID: 19889077   DOI: 10.1111/j.1523-5378.2009.00724.x
8460  Zaidi SF, Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T.  Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.  Biol. Pharm. Bull.  2009  32:1931-5  PubMed ID: 19881312   DOI: 10.1248/bpb.32.1931
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8601  Auyeung KK, Cho CH, Ko JK.  A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.  Int. J. Cancer  2009  125:1082-91  PubMed ID: 19384947   DOI: 10.1002/ijc.24397
18961  Peng TL, Chen J, Mao W, Liu X, Tao Y, Chen LZ, Chen MH.  Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer  World J Gastroenterol  2009  15(14):1719-29.  PubMed ID: 19360915   DOI: 10.3748/wjg.15.1719
18972  Franke K, Carl-McGrath S, Röhl FW, Lendeckel U, Ebert MP, Tänzer M, Pross M, Röcken C.  Differential Expression of SPARC in Intestinal-type Gastric Cancer Correlates with Tumor Progression and Nodal Spread  Transl Oncol  2009  2(4):310-20  PubMed ID: 19956393   DOI: 10.1593/tlo.09169
19055  Wang LJ, Jin HC, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ.  ZIC1 is downregulated through promoter hypermethylation in gastric cancer  Biochem Biophys Res Commun  2009  379(4):959-63  PubMed ID: 19135984   DOI: 10.1016/j.bbrc.2008.12.180
19057  Carl-McGrath S, Gräntzdörffer I, Lendeckel U, Ebert MP, Röcken C.  Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines  Pathology  2009  41(5):419-27  PubMed ID: 19424904   DOI: 10.1080/00313020902885037
5031  Ohnuma S, Miura K, Horii A, Fujibuchi W, Kaneko N, Gotoh O, Nagasaki H, Mizoi T, Tsukamoto N, Kobayashi T, Kinouchi M, Okabe M, Sasaki H, Shiiba K, Miyagawa K, Sasaki I.  Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues.  Surgery  2009  145(1):57-68  PubMed ID: 19081476   DOI: 10.1016/j.surg.2008.08.010
5873  Yu J, Cheng YY, Tao Q, Cheung KF, Lam CN, Geng H, Tian LW, Wong YP, Tong JH, Ying JM, Jin H, To KF, Chan FK, Sung JJ.  Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.  Gastroenterology  2009  136(2):640  PubMed ID: 19084528   DOI: 10.1053/j.gastro.2008.10.050
5874  Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.  p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.  Am J Physiol Gastrointest Liver Physiol  2009  297(2):G385-96  PubMed ID: 19541923   DOI: 10.1152/ajpgi.90620.2008
5876  Takaishi S1, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.  Identification of gastric cancer stem cells using the cell surface marker CD44.  Stem Cells.   2009  27(5):1006-20  PubMed ID: 19415765   DOI: 10.1002/stem.30
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
5883  Li J, Ng EK, Ng YP, Wong CY, Yu J, Jin H, Cheng VY, Go MY, Cheung PK, Ebert MP, Tong J, To KF, Chan FK, Sung JJ, Ip NY, Leung WK.  Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer  Br J Cancer  2009  101(4):691-8  PubMed ID: 19672268   DOI: 10.1038/sj.bjc.6605202
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
18418  Goto K, Tanaka Y, Matsumoto Y, Ueoka R.  Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid  Bioorg Med Chem Lett  2008  18(6):1880-3  PubMed ID: 18294848   DOI: 10.1016/j.bmcl.2008.02.019
18960  Matsuda K, Yamauchi K, Matsumoto T, Sano K, Yamaoka Y, Ota H.  Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and  Scand J Gastroenterol  2008  43(1):25-33  PubMed ID: 18938748   DOI: 10.1080/00365520701579795
18966  Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Okada Y, Takeyama H, Manabe T.  Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines  J Surg Res  2008  148(2):197-204  PubMed ID: 18395750   DOI: 10.1016/j.jss.2007.08.014
18978  Yamauchi K, Choi IJ, Lu H, Ogiwara H, Graham DY, Yamaoka Y.  Regulation of IL-18 in Helicobacter pylori infection  J Immunol  2008  180(2):1207-16  PubMed ID: 18178861   DOI: 10.4049/jimmunol.180.2.1207
3574  Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T.  Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity.  Cancer Gene Ther.  2008  15(1):51-9  PubMed ID: 17992202   DOI: 10.1038/sj.cgt.7701104
5885  Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, Zeng Z, Shah M, Christensen JG, Rosen N, Solit DB, Weiser MR.  HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells.  Mol Cancer Ther  2008  7(11):3499-508  PubMed ID: 18974395   DOI: 10.1158/1535-7163.MCT-08-0374
5886  Inoue M, Matsumoto S, Saito H, Tsujitani S, Ikeguchi M.  Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer.  Int J Cancer.   2008  123(11):2696-701  PubMed ID: 18798274   DOI: 10.1002/ijc.23867
5887  Hara M, Nakanishi H, Tsujimura K, Matsui M, Yatabe Y, Manabe T, Tatematsu M.  Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity.  Cancer Sci  2008  99(7):1471-8  PubMed ID: 18422755   DOI: 10.1111/j.1349-7006.2008.00821.x
5889  Sakurai Y, Yoshida I, Kamoshida S, Inaba K, Isogaki J, Komori Y, Uyama I, Tsutsumi Y.  Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts.  Anticancer Res  2008  28(3A):1593-602  PubMed ID: 18630517  
5891  Tozawa K, Oshima T, Kobayashi T, Yamamoto N, Hayashi C, Matsumoto T, Miwa H  Oxaliplatin in treatment of the cisplatin-resistant MKN45 cell line of gastric cancer.  Anticancer Res  2008  28(4B):2087-92  PubMed ID: 18751380  
6139  Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y.  IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  Int J Cancer  2008  122(5):1040-6  PubMed ID: 17957782   DOI: 10.1002/ijc.23181
7935  Han Z, Wu K, Shen H, Li C, Han S, Hong L, Shi Y, Liu N, Guo C, Xue Y, Qiao T, Fan D.  Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation.  Dig Dis Sci  2008  53(7):1801-10  PubMed ID: 18379876   DOI: 10.1007/s10620-007-9824-2
13878  Tanaka Y, Goto K, Matsumoto Y, Ueoka R.  Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis  Int J Pharm  2008  359(1-2):264-71  PubMed ID: 18511224   DOI: 10.1016/j.ijpharm.2008.03.045
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18621  Lu H, Wu JY, Beswick EJ, Ohno T, Odenbreit S, Haas R, Reyes VE, Kita M, Graham DY, Yamaoka Y.  Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains  J Biol Chem  2007  282(9):6242-54  PubMed ID: 17202133   DOI: 10.1074/jbc.M611178200
18853  Carl-McGrath S, Ebert MP, Lendeckel U, Röcken C.  Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread  Cancer Biol Ther  2007  6(8):1218-26  PubMed ID: 18059164   DOI: 10.4161/cbt.6.8.4412
18924  Osaki T, Saito H, Yoshikawa T, Matsumoto S, Tatebe S, Tsujitani S, Ikeguchi M.  Decreased NKG2D expression on CD8+ T cell is involved in immune evasion in patients with gastric cancer  Clin Cancer Res  2007  13(2 Pt 1):382-7  PubMed ID: 17255258   DOI: 10.1158/1078-0432.CCR-06-1454
18969  Takahashi H, Murai Y, Tsuneyama K, Nomoto K, Okada E, Fujita H, Takano Y.  High labeling indices of cdc25B is linked to progression of gastric cancers and associated with a poor prognosis  Appl Immunohistochem Mol Morphol  2007  15(3):267-72  PubMed ID: 17721270   DOI: 10.1097/01.pai.0000213120.58472.57
19035  Chan MW, Wong CY, Cheng AS, Chan VY, Chan KK, To KF, Chan FK, Sung JJ, Leung WK.  Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells  Oncol Rep  2007  18(6):1557-62  PubMed ID: 17982644  
5892  Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Aikou T.  Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer.  Br J Surg  2007  94(8):984-91  PubMed ID: 17410638   DOI: 10.1002/bjs.5717
5893  Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T.  Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.  Clin Exp Metastasis  2007  24(3):179-89  PubMed ID: 17487561   DOI: 10.1007/s10585-007-9067-9
5895  Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A.  Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.  Cancer Res  2007  67(18):8682-9  PubMed ID: 17875708   DOI: 10.1158/0008-5472.CAN-07-1586
15600  Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK.  Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer  Br J Cancer  2007  97(7):895-901  PubMed ID: 17848950   DOI: 10.1038/sj.bjc.6603968
16154  Higashiyama M, Ito T, Tanaka E, Shimada Y.  Prognostic significance of osteopontin expression in human gastric carcinoma  Ann Surg Oncol  2007  14(12):3419-27  PubMed ID: 17896150   DOI: 10.1245/s10434-007-9564-8
3430  Wu, Jeng Yih, Lu, Hong, Sun, Yubo, Graham, David Y, Cheung, Herman S, Yamaoka, Yoshio  Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression.  Cancer Res  2006  66:5111-20  PubMed ID: 16707434   DOI: 10.1158/0008-5472.CAN-06-0383
8916  Hitoshi KAWAMOTO, Yasunari MIKI, Takayuki KIMURA, Katsunori TANAKA, Tsuyoshi NAKAGAWA, Makoto KAWAMUKAI and Hideyuki MATSUDA  Effects of fucoidan from Mozuku on human stomach cell lines  Food Sci Technol Res  2006  12:218-222    DOI: 10.3136/fstr.12.218
18965  Koga Y, Kitajima Y, Miyoshi A, Sato K, Sato S, Miyazaki K.  The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer  J Gastroenterol  2006  41(2):133-9  PubMed ID: 16568372   DOI: 10.1007/s00535-005-1732-7
19059  Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MC, Wang J, He H, Jiang SH, Sun YW, Yu LF, Yuen ST, Kung HF, Wong BC.  Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers  Gastroenterology  2006  131(6):1835-43  PubMed ID: 17087954   DOI: 10.1053/j.gastro.2006.09.050
5897  Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M.  Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.  Oncology  2006  70(2):126-33  PubMed ID: 16645325   DOI: 10.1159/000093003
5898  Handa O, Yoshida N, Fujita N, Tanaka Y, Ueda M, Takagi T, Kokura S, Naito Y, Okanoue T, Yoshikawa T.  Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors.  Inflamm Res  2006  55(11):476-80  PubMed ID: 17122965   DOI: 10.1007/s00011-006-6056-4
5899  Yokoyama H, Ikehara Y, Kodera Y, Ikehara S, Yatabe Y, Mochizuki Y, Koike M, Fujiwara M, Nakao A, Tatematsu M, Nakanishi H.  Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.  Br J Cancer  2006  95(11):1504-13  PubMed ID: 17088902   DOI: 10.1038/sj.bjc.6603459
5900  Xia HH, He H, De Wang J, Gu Q, Lin MC, Zou B, Yu LF, Sun YW, Chan AO, Kung HF, Wong BC.  Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.  Cancer Lett  2006  241(2):268-74  PubMed ID: 16337741   DOI: 10.1016/j.canlet.2005.10.031
5904  Matsumoto S, Saito H, Tsujitani S, Ikeguchi M.  Allogeneic gastric cancer cell-dendritic cell hybrids induce tumor antigen (carcinoembryonic antigen) specific CD8(+) T cells.  Cancer Immunol Immunother  2006  55(2):131-9  PubMed ID: 15891883   DOI: 10.1007/s00262-005-0684-3
5907  Sako A, Kitayama J, Shida D, Suzuki R, Sakai T, Ohta H, Nagawa H.  Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.  J Surg Res  2006  130(1):94-101  PubMed ID: 16171822   DOI: 10.1016/j.jss.2005.08.007
3109  Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao  COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.  DNA Cell Biol  2005  24:141-7  PubMed ID: 15767780   DOI: 10.1089/dna.2005.24.141
3167  Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789   DOI: 10.1248/bpb.28.574
3375  Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.  Cancer Res.  2005  65:10822-9  PubMed ID: 16322228   DOI: 10.1158/0008-5472.CAN-05-0777
3867  Nakagiri A, Kato S, Takeuchi K.  Irritative action of alcoholic beverages in rat stomachs: a comparative study with ethanol.  Inflammopharmacology  2005  13(1-3):273-9  PubMed ID: 16259746   DOI: 10.1163/156856005774423845
5908  Ohashi N, Kodera Y, Nakanishi H, Yokoyama H, Fujiwara M, Koike M, Hibi K, Nakao A, Tatematsu M.  Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice.  nt J Oncol  2005  27(3):637-44  PubMed ID: 16077911  
5911  Kanzaki N, Terashima M, Kashimura S, Hoshino M, Ohtani S, Matsuyama S, Hoshino Y, Kogure M, Oshibe I, Endo H, Saito T, Yaginuma H, Gotoh M, Ohto H.  Understanding the response of dendritic cells to activation by streptococcal preparation OK-432.  Anticancer Res  2005  25(6B):4231-8  PubMed ID: 16309221  
5913  Kakinuma N, Sato M, Yamada T, Kohu K, Nakajima M, Akiyama T, Ohwada S, Shibanaka Y.  Cloning of novel LERGU mRNAs in GPR30 3' untranslated region and detection of 2 bp-deletion polymorphism in gastric cancer.  Cancer Sci  2005  96(3):191-6  PubMed ID: 15771623   DOI: 10.1111/j.1349-7006.2005.00031.x
5914  Xia HH, Lam SK, Chan AO, Lin MC, Kung HF, Ogura K, Berg DE, Wong BC.  Macrophage migration inhibitory factor stimulated by Helicobacter pylori increases proliferation of gastric epithelial cells.  World J Gastroenterol  2005  11(13):1946-50  PubMed ID: 15800984   DOI: 10.3748/wjg.v11.i13.1946
5917  Endo K, Kohnoe S, Tsujita E, Watanabe A, Nakashima H, Baba H, Maehara Y.  Modulation of anti-apoptosis by endogenous IAP expression in MKN45 human gastric cancer cells.  Anticancer Res  2005  25(4):2713-7  PubMed ID: 16080516  
5919  Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi  The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines  Yonago Acta medica  2005  48:7–16   
5920  Chang YJ, Wu MS, Lin JT, Chen CC.  Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation.  J Immunol  2005  175(12):8242-52  PubMed ID: 16339564   DOI: 10.4049/jimmunol.175.12.8242
6449  Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M.  Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping.  World J Gastroenterol  2005  11(33):5129-35  PubMed ID: 16127741   DOI: 10.3748/wjg.v11.i33.5129
3596  Fujiwara H, Kubota T, Amaike H, Inada S, Takashima K, Atsuji K, Yoshimura M, Maemondo M, Narumi K, Nukiwa T, Matsumoto K, Nakamura T, Hagiwara A, Yamagishi H.  Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression.  Cancer Gene Ther  2005  12(2):206-16  PubMed ID: 15486556   DOI: 10.1038/sj.cgt.7700782
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5869  野田頭 達也, 小田桐 弘毅, 池永 照史郎一期, 丸山 将輝, 佐藤 利行, 袴田 健一  Cre/loxP system を用いた HER2/neu 発現細胞に対する特異的かつ効率的遺伝子導入システムの開発  弘前医学  2010  61:26―34    DOI: 10.32216/hirosakiigaku.61.1_26



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