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Cell No. : Cell Name
RCB1001 : MKN45  update : 2022/12/05
CommentPoorly differentiated gastric adenocarcinoma. Producing high level of CEA.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Motoyama, Teiichi
Originator Hojo, Haruto
Year of deposit 1994
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 62 years
Tissue stomach, liver meta
Disease name Gastric adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue liver
Classification cancer
Year of origin 1975
History Hojo, Haruto - Motoyama, Teiichi
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0434
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Virus (HIV) Lot.1 : (-)
Virus (HBV) Lot.1 : (-)
Virus (HCV) Lot.1 : (-)
Chromosome mode 40-44(50) : 40(1),41(1),42(7),43(36),44(5)
STR(human) OK
deposit info
lot info
Reference information Reference 10
User's Publication 318

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4399  Homma N, Tamura G, Honda T, Matsumoto Y, Nishizuka S, Kawata S, Motoyama T.  Spreading of methylation within RUNX3 CpG island in gastric cancer.  Cancer Sci  2006  97(1):51-6  PubMed ID: 16367921   DOI: 10.1111/j.1349-7006.2005.00133.x
4501  Yanagawa N, Tamura G, Honda T, Endoh M, Nishizuka S, Motoyama T.  Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.  Clin Cancer Res  2004  10(7):2447-51  PubMed ID: 15073123   DOI: 10.1158/1078-0432.ccr-03-0107
4447  Ogose A, Motoyama T, Hotta T, Watanabe H.  Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells.  Pathol Int.   1996  46(1):9-14  PubMed ID: 10846544   DOI: 10.1111/j.1440-1827.1996.tb03527.x
11693  T Fujiwara, T Motoyama, N Ishihara, H Watanabe, T Kumanishi, K Kato, H Ichinose, T Nagatsu  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma  Int J Cancer  1993  54(6):965-71  PubMed ID: 8392984   DOI: 10.1002/ijc.2910540617
3128  Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res.  1991  82:1428-35  PubMed ID: 1778766   DOI: 10.1111/j.1349-7006.1991.tb01816.x
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682   DOI: 10.1111/j.1349-7006.1990.tb03332.x
3126  Yokoyama I, Watanabe T, Nishikimi M, Ichihashi H, Kondo T, Takagi H, Sakuma S  Radioimmunoscintigraphy of human gastric carcinoma xenografts with 125I-labeled monoclonal antibody.  Jpn J Cancer Res  1986  77:1114-21  PubMed ID: 3098721  
1889  Motoyama T, Hojo H, Watanabe H  Comparison of seven cell lines derived from human gastric carcinomas.  Acta Pathol Jpn  1986  36:65-83  PubMed ID: 3962675   DOI: 10.1111/j.1440-1827.1986.tb01461.x
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
1861  Motoyama T, Watanabe H.  Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice.  Gan  1983  74(5):679-86  PubMed ID: 6642141  

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User's Publication
21016  Zhu S, Al-Mathkour M, Cao L, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Hu T, McDonald OG, Zaika A, El-Rifai W.  CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis.  Cell Rep  2023  42(1):112005  PubMed ID: 36681899   DOI: 10.1016/j.celrep.2023.112005
20316  Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N, Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K, Tashiro H.  Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.  J Gastrointest Surg  2022    PubMed ID: 34379296   DOI: 10.1007/s11605-021-05101-2
20377  Khalafi S, Zhu S, Khurana R, Lohse I, Giordano S, Corso S, Al-Ali H, Brothers SP, Wahlestedt C, Schürer S, El-Rifai W.  A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer.  Transl Oncol  2022  15(1):101260  PubMed ID: 34735897   DOI: 10.1016/j.tranon.2021.101260
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20476  Ando-Matsuoka R, Ando H, Abu Lila AS, Maeda N, Shimizu T, Ishima Y, Ishida T.  I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors.  J Control Release  2022    PubMed ID: 34896447   DOI: 10.1016/j.jconrel.2021.12.004
20571  Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.  Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.  Gastric Cancer  2022    PubMed ID: 35166958   DOI: 10.1007/s10120-022-01283-z
20600  Xie J, Fu L, Zhang J.  Analysis of Influencing Factors on the Occurrence and Development of Gastric Cancer in High-Incidence Areas of Digestive Tract Tumors Based on High Methylation of GPX3 Gene.  J Oncol  2022  3094881  PubMed ID: 35069731   DOI: 10.1155/2022/3094881
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
20664  Han Y, Dong Q, Liu T, Chen X, Yu C, Zhang Y.  The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.  Biochem Biophys Res Commun  2022  610:1-7  PubMed ID: 35461070   DOI: 10.1016/j.bbrc.2022.04.029
20688  Watanabe T, Nishio Y, Yamamoto Y, Shimizu T, Li XK, Okita H, Kuroda T.  Photodynamic therapy with 5-aminolevulinic acid: A new diagnostic, therapeutic, and surgical aid for neuroblastoma.  J Pediatr Surg  2022    PubMed ID: 35396087   DOI: 10.1016/j.jpedsurg.2022.02.028
16894  Kimura Y, Ohzawa H, Miyato H, Kaneko Y, Saito A, Takahashi K, Tojo M, Yamaguchi H, Kurashina K, Saito S, Hosoya Y, Lefor AK, Sata N, Kitayama J.  MiR-29b may suppresses peritoneal metastases through inhibition of the mesothelial-mesenchymal transition (MMT) of human peritoneal mesothelial cells  Sci Rep  2022  12(1):205  PubMed ID: 34997082   DOI: 10.1038/s41598-021-04065-2
20825  Wang Q, Chen C, Xu X, Shu C, Cao C, Wang Z, Fu Y, Xu L, Xu K, Xu J, Xia A, Wang B, Xu G, Zou X, Su R, Kang W, Xue Y, Mo R, Sun B, Wang S.  APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.  Adv Sci (Weinh)  2022  e2201889  PubMed ID: 35975461   DOI: 10.1002/advs.202201889
16979  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  Front Oncol  2022  12:802009  PubMed ID: 35251974   DOI: 10.3389/fonc.2022.802009
20887  Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W.  MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.  Theranostics  2022  12(15):6509-6526  PubMed ID: 36185598   DOI: 10.7150/thno.75431
20953  Sugezawa K, Morimoto M, Yamamoto M, Matsumi Y, Nakayama Y, Hara K, Uejima C, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Umekita Y, Fujiwara Y.  GPX4 Regulates Tumor Cell Proliferation via Suppressing Ferroptosis and Exhibits Prognostic Significance in Gastric Cancer.  Anticancer Res  2022  42(12):5719-5729  PubMed ID: 36456115   DOI: 10.21873/anticanres.16079
13245  Hasegawa K, Fujii S, Matsumoto S, Tajiri Y, Kikuchi A, Kiyoshima T.  YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation.  J Pathol  2021    PubMed ID: 32985688   DOI: 10.1002/path.5553
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
13361  Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T.  Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.  Fitoterapia  2021    PubMed ID: 33246033   DOI: 10.1016/j.fitote.2020.104780
20036  Akagi S, Ando H, Fujita K, Shimizu T, Ishima Y, Tajima K, Matsushima T, Kusano T, Ishida T.  Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model.  Int J Biol Macromol  2021  174:494-501  PubMed ID: 33545180   DOI: 10.1016/j.ijbiomac.2021.01.201
20061  Iwamuro M, Shiraha H, Oyama A, Uchida D, Horiguchi S, Okada H.  Laminin-411 and -511 Modulate the Proliferation, Adhesion, and Morphology of Gastric Cancer Cells.  Cell Biochem Biophys  2021    PubMed ID: 33629255   DOI: 10.1007/s12013-021-00972-3
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
14292  Hernández C, Toledo-Stuardo K, García-González P, Garrido-Tapia M, Kramm K, Rodríguez-Siza JA, Hermoso M, Ribeiro CH, Molina MC.  Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4  Helicobacter  2021  e12812  PubMed ID: 33928707   DOI: 10.1111/hel.12812
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
20224  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E.  Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer.  Photodiagnosis Photodyn Ther  2021    PubMed ID: 34242818   DOI: 10.1016/j.pdpdt.2021.102420
20385  Ito K, Kitajima Y, Kai K, Matsufuji S, Yamada K, Egawa N, Kitagawa H, Okuyama K, Tanaka T, Noshiro H.  Matrix metalloproteinase‑1 expression is regulated by HIF‑1‑dependent and epigenetic mechanisms and serves a tumor‑suppressive role in gastric cancer progression.  Int J Oncol  2021  59(6)  PubMed ID: 34738626   DOI: 10.3892/ijo.2021.5282
20415  Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T.  Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.  Oncol Lett  2021  22(4):735  PubMed ID: 34466148   DOI: 10.3892/ol.2021.12996
20421  Reyna-Jeldes M, De la Fuente-Ortega E, Cerda D, Velázquez-Miranda E, Pinto K, Vázquez-Cuevas FG, Coddou C.  Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines.  Pharmaceutics  2021  13(8)  PubMed ID: 34452195   DOI: 10.3390/pharmaceutics13081234
20520  Komatsu S, Imamura T, Kiuchi J, Takashima Y, Kamiya H, Ohashi T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer.  Am J Cancer Res  2021  11(12):6133-6146  PubMed ID: 35018247  
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
16803  Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H.  Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells  FEBS Open Bio  2021  11(5):1465-1475  PubMed ID: 33773069   DOI: 10.1002/2211-5463.13154
11630  Nishimura T, Mitsunaga M, Ito K, Kobayashi H, Saruta M.  Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT.  Gastric Cancer  2020  23(1):82-94  PubMed ID: 31302791   DOI: 10.1007/s10120-019-00988-y
12041  Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S.  FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.  Oncogenesis  2020    PubMed ID: 32029704   DOI: 10.1038/s41389-020-0190-7
13071  Tiffon C, Giraud J, Molina-Castro SE, Peru S, Seeneevassen L, Sifré E, Staedel C, Bessède E, Dubus P, Mégraud F, Lehours P, Martin OCB, Varon C.  TAZ Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties.  Cells  2020    PubMed ID: 32545795   DOI: 10.3390/cells9061462
13242  Uejima C, Morimoto M, Yamamoto M, Hara K, Miyauchi W, Sugezawa K, Tada Y, Tanio A, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y.  Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer.  Anticancer Res  2020  40(10):5593-5600  PubMed ID: 32988883   DOI: 10.21873/anticanres.14572
13299  Wang J, Li Q, Cheng X, Zhang B, Lin J, Tang Y, Li F, Yang CS, Wang TC, Tu S.  Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop.  Onco Targets Ther  2020    PubMed ID: 33116635   DOI: 10.2147/OTT.S266506
13504  Baatar S, Bai T, Yokobori T, Gombodorj N, Nakazawa N, Ubukata Y, Kimura A, Kogure N, Sano A, Sohda M, Sakai M, Tumenjargal A, Ogata K, Kuwano H, Shirabe K, Saeki H.  High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer  Ann Surg Oncol  2020  27(11):4360-4368  PubMed ID: 32356270   DOI: 10.1245/s10434-020-08518-2
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
13838  He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S.  MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression  FASEB J  2020  34(6):8544-8557  PubMed ID: 32356314   DOI: 10.1096/fj.201903217R
14297  Kumagai Y, Ohzawa H, Miyato H, Horie H, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Surgical Stress Increases Circulating Low-Density Neutrophils Which May Promote Tumor Recurrence  J Surg Res  2020  246:52-61  PubMed ID: 31561178   DOI: 10.1016/j.jss.2019.08.022
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14844  Zhu S, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Que J, Garcia-Buitrago M, Zaika A, El-Rifai W.  Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib  Cancer Lett  2020  491:87-96  PubMed ID: 32735911   DOI: 10.1016/j.canlet.2020.07.014
14847  Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T.  Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance  Cancer Res  2020  80(16):3222-3235  PubMed ID: 32605995   DOI: 10.1158/0008-5472.CAN-19-3803
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11409  Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M.  NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells.  Oncogene  2019    PubMed ID: 30700829   DOI: 10.1038/s41388-019-0702-0
11448  Kim JH, Eom HJ, Lim G, Park S, Lee J, Nam S, Kim YH, Jeong JH.  Differential effects, on oncogenic pathway signalling, by derivatives of the HNF4 α inhibitor BI6015.  Br. J. Cancer  2019    PubMed ID: 30792535   DOI: 10.1038/s41416-018-0374-5
11456  Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H.  Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.  Sci Rep  2019    PubMed ID: 30808977   DOI: 10.1038/s41598-019-39563-x
6418  Hevia MJ, Castro P, Pinto K1, Reyna-Jeldes M, Rodríguez-Tirado F, Robles-Planells C, Ramírez-Rivera S, Madariaga JA, Gutierrez F, López J, Barra M, De la Fuente-Ortega E, Bernal G, Coddou C.  Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors.  Front Pharmacol  2019  10:612  PubMed ID: 31249523   DOI: 10.3389/fphar.2019.00612
6419  Lin HJ, Jiang ZP, Lo HR, Feng CL, Chen CJ, Yang CY, Huang MZ, Wu HY, Chen YA, Chen Y, Chiu CH, Lai CH  Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation.  Front Immunol  2019  10:109  PubMed ID: 30863392   DOI: 10.3389/fimmu.2019.00109
11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217   DOI: 10.1016/j.bbrep.2019.100632
11527  Ando H, Abu Lila AS, Fukushima M, Matsuoka R, Shimizu T, Okuhira K, Ishima Y, Huang CL, Wada H, Ishida T.  A simplified method for manufacturing RNAi therapeutics for local administration.  Int J Pharm  2019    PubMed ID: 31015002   DOI: 10.1016/j.ijpharm.2019.04.054
11613  Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W.  Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.  Oncogene  2019  38(29):5805-5816  PubMed ID: 31235784   DOI: 10.1038/s41388-019-0843-1
11695  Shunsuke Odai, Hidehiro Ito, Toshiaki Kamachi  Dendrimer porphyrins as the oxygen sensor for intracellular imaging to suppress interaction towards biological molecules  Journal of Clinical Biochemistry and Nutrition  2019    PubMed ID: 31777418   DOI: 10.3164/jcbn.19-13
11733  Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.  Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.  Int. J. Oncol.  2019    PubMed ID: 31432150   DOI: 10.3892/ijo.2019.4853
11850  Ando H, Fukushima M, Eshima K, Hasui T, Shimizu T, Ishima Y, Huang CL, Wada H, Ishida T.  A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model.  Cancer Med  2019    PubMed ID: 31609087   DOI: 10.1002/cam4.2598
6888  Nakayama T, Kobayashi T, Shimpei O, Fukuhara H, Namikawa T, Inoue K, Hanazaki K, Takahashi K, Nakajima M, Tanaka T, Ogura SI.  Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway.  Photodiagnosis Photodyn Ther  2019  28:10-17  PubMed ID: 31404677   DOI: 10.1016/j.pdpdt.2019.07.021
10444  Yuta Sugiyama, Erika Takahashi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura  Inverse correlation between heme synthesis and the Warburg effect in cancer cells  bioRxiv  2019  August 30    DOI: 10.1101/753079
11904  Gomaa A, Peng D, Chen Z, Soutto M, Abouelezz K, Corvalan A, El-Rifai W.  Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers.  Sci Rep  2019    PubMed ID: 31740746   DOI: 10.1038/s41598-019-53174-6
11969  Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S.  Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma.  Sci Rep  2019    PubMed ID: 31873082   DOI: 10.1038/s41598-019-55465-4
12422  Miyagi A, Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents  Biol Pharm Bull  2019  42(4):638-644.  PubMed ID: 30930422   DOI: 10.1248/bpb.b18-00855
12423  Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W.  Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1  Gastroenterology  2019  156(3):662-675.e7  PubMed ID: 30342037   DOI: 10.1053/j.gastro.2018.10.030
12424  Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect  J Pharmacol Sci  2019  140(3):291-294  PubMed ID: 31377017   DOI: 10.1016/j.jphs.2019.05.009
10736  Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W.  A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.  Clin. Cancer Res.  2018  24:1905-1916  PubMed ID: 29386219   DOI: 10.1158/1078-0432.CCR-17-1716
10744  Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang LJ, Chen SJ.  HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells.  Gastric Cancer  2018  21(5):756-764  PubMed ID: 29417297   DOI: 10.1007/s10120-018-0801-6
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007   DOI: 10.1038/s41416-018-0008-y
10831  Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T.  A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.  Biol. Pharm. Bull.  2018  41:733-742  PubMed ID: 29709910   DOI: 10.1248/bpb.b17-00919
11106  Guan SS, Wu CT, Chiu CY, Luo TY, Wu JY, Liao TZ, Liu SH.  Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo.  J Transl Med  2018  16(1):168  PubMed ID: 29921305   DOI: 10.1186/s12967-018-1550-3
11210  Nguyen PH, Touchefeu Y, Durand T, Aubert P, Duchalais E, Bruley des Varannes S, Varon C, Neunlist M, Matysiak-Budnik T.  Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type.  Tumour Biol.  2018    PubMed ID: 30207200   DOI: 10.1177/1010428318799028
11211  Osanai-Sasakawa A, Hosomi K, Sumitomo Y, Takizawa T, Tomura-Suruki S, Imaizumi M, Kasai N, Poh TW, Yamano K, Yong WP, Kono K, Nakamura S, Ishii T, Nakai R.  An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models.  Am J Cancer Res  2018    PubMed ID: 30210919  
11219  Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H.  Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties.  Oncol Lett  2018    PubMed ID: 30250614   DOI: 10.3892/ol.2018.9301
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
11282  Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H.  The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis.  Anticancer Res.  2018    PubMed ID: 30396946   DOI: 10.21873/anticanres.12982
11280  Ueta K, Otowa Y, Kakeji Y, Hirashima M.  PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer.  Anticancer Res.  2018    PubMed ID: 30396930   DOI: 10.21873/anticanres.12966
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864   DOI: 10.3892/or.2017.6093
4301  Tsai WH, Yu KH, Huang YC, Lee CI.  EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles.  Int J Nanomedicine  2018    PubMed ID: 29445279   DOI: 10.2147/IJN.S148305
4302  Shin VY, Siu MT, Liu X, Ng EKO, Kwong A, Chu KM.  MiR-92 suppresses proliferation and induces apoptosis by targeting EP4/Notch1 axis in gastric cancer.  Oncotarget  2018    PubMed ID: 29849934   DOI: 10.18632/oncotarget.24819
4304  Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X.  Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.  Oncol Lett  2018    PubMed ID: 29805691   DOI: 10.3892/ol.2018.8562
4313  Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.  Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.  Am J Cancer Res  2018    PubMed ID: 30662802  
5801  Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z.  Targeting IRF3 as a YAP agonist therapy against gastric cancer.  J Exp Med  2018  215(2):699-718  PubMed ID: 29339449   DOI: 10.1084/jem.20171116
13126  Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K.  Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.  Cancer Sci  2018    PubMed ID: 30290054   DOI: 10.1111/cas.13824
14263  Shao L, Chen Z, Peng D, Soutto M, Zhu S, Bates A, Zhang S, El-Rifai W.  Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells  Mol Cancer Res  2018  16(4):696-706  PubMed ID: 29453320   DOI: 10.1158/1541-7786.MCR-17-0655
14602  Kanamaru R, Ohzawa H, Miyato H, Yamaguchi H, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment  J Vis Exp  2018  (138):58201  PubMed ID: 30124642   DOI: 10.3791/58201
14733  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma  Carcinogenesis  2018  39(2):263-271  PubMed ID: 29228320   DOI: 10.1093/carcin/bgx139
14901  Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K.  Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis  Mol Cancer Res  2018  16(3):554-563  PubMed ID: 29330298   DOI: 10.1158/1541-7786.MCR-17-0393
9788  Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y.  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma.  Gastric Cancer  2017  20:416-427  PubMed ID: 27517839   DOI: 10.1007/s10120-016-0627-z
10088  Tanaka S, Nagashima H, Uotani T, Graham DY, Yamaoka Y.  Autophagy-related genes in Helicobacter pylori infection.  Helicobacter  2017  22:  PubMed ID: 28111844   DOI: 10.1111/hel.12376
10177  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.  Oncol Lett  2017  13:3127-3130  PubMed ID: 28521417   DOI: 10.3892/ol.2017.5836
10253  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells.  Oncol Lett  2017  13:4322-4326  PubMed ID: 28599433   DOI: 10.3892/ol.2017.5987
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10328  Suzuki N, Nakagawa F, Takechi T.  Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.  Oncol Lett  2017  14:639-646  PubMed ID: 28693216   DOI: 10.3892/ol.2017.6258
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175   DOI: 10.3892/or.2017.5844
10486  Shibaguchi H, Luo N, Shirasu N, Kuroki M, Kuroki M.  Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen.  Onco Targets Ther  2017  10:3979-3990  PubMed ID: 28860806   DOI: 10.2147/OTT.S140174
10652  Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S.  Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F.  Oncotarget  2017  8:97371-97383  PubMed ID: 29228617   DOI: 10.18632/oncotarget.22126
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969   DOI: 10.18632/oncotarget.20860
10722  Lan KH, Lee WP, Wang YS, Liao SX, Lan KH.  Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells.  Oncotarget  2017  8:113460-113471  PubMed ID: 29371922   DOI: 10.18632/oncotarget.23050
10955  Kitayama J, Ishigami H, Yamaguchi H, Yamada J, Soma D, Miyato H, Kamei T, Lefor AK, Sata N.  Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model  Pleura Peritoneum  2017  2:95-102  PubMed ID: 30911637   DOI: 10.1515/pp-2017-0002
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5806  Shiroki T et al  Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.  Cancer Sci  2017  108(5):931-940  PubMed ID: 28235245   DOI: 10.1111/cas.13211
13680  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Proliferation and motility of hepatocellular, pancreatic and gastric cancer cells grown in a medium without glucose and arginine, but with galactose and ornithine  Oncol Lett  2017  13(3):1276-1280  PubMed ID: 28454246   DOI: 10.3892/ol.2017.5568
14097  Kimura A, Ogata K, Altan B, Yokobori T, Mochiki E, Yanai M, Kogure N, Yanoma T, Suzuki M, Bai T, Kuwano H.  Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis  World J Gastroenterol  2017  23(42):7541-7550  PubMed ID: 29204054   DOI: 10.3748/wjg.v23.i42.7541
14358  Garrido-Tapia M, Hernández CJ, Ascui G, Kramm K, Morales M, Ga Rate V, Zúñiga R, Bustamante M, Aguillón JC, Catala N D, Ribeiro CH, Molina MAC.  STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells  Immunobiology  2017  222(11):1043-1051  PubMed ID: 28578917   DOI: 10.1016/j.imbio.2017.05.009
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14619  Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E.  Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer  Oncotarget  2017  8(60):101394-101405  PubMed ID: 29254173   DOI: 10.18632/oncotarget.20736
14663  Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M, Nakajima Y.  Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer  Oncol Lett  2017  13(5):3131-3138  PubMed ID: 28521418   DOI: 10.3892/ol.2017.5806
14735  Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS.  Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil  Sci Rep  2017  7(1):2262  PubMed ID: 28536445   DOI: 10.1038/s41598-017-02548-9
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
14746  Chen Z, Hu T, Zhu S, Mukaisho K, El-Rifai W, Peng DF.  Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer  Oncotarget  2017  8(33):54345-54356  PubMed ID: 28903346   DOI: 10.18632/oncotarget.17527
14747  Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jiménez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, Graham DY, Yamaoka Y.  Interleukin-17C in Human Helicobacter pylori Gastritis  Infect Immun  2017  85(10):e00389-17  PubMed ID: 28739826   DOI: 10.1128/IAI.00389-17
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9541  Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H.  Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.  BMC Cancer  2016  16:37  PubMed ID: 26810644   DOI: 10.1186/s12885-016-2072-0
9542  Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.  Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia.  Int. J. Oncol.  2016  48:1379-90  PubMed ID: 26820502   DOI: 10.3892/ijo.2016.3359
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9625  Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K.  Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.  J. Gastroenterol.  2016  51:1101-1111  PubMed ID: 27002316   DOI: 10.1007/s00535-016-1197-x
9652  Lan H, Tang Z, Jin H, Sun Y.  Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.  Sci Rep  2016  6:24218  PubMed ID: 27063292   DOI: 10.1038/srep24218
9672  Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP.  Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.  Oncogene  2016  35:5388-5399  PubMed ID: 27109105   DOI: 10.1038/onc.2016.76
9760  Zhou J, You W, Sun G, Li Y, Chen B, Ai J, Jiang H.  The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis.  J. Pharmacol. Exp. Ther.  2016  359:54-61  PubMed ID: 27432893   DOI: 10.1124/jpet.116.234799
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9902  Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T.  Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer.  Anticancer Res.  2016  36:6005-6009  PubMed ID: 27793927   DOI: 10.21873/anticanres.11189
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12656  Kitayama J, Yamaguchi H, Ishigami H, Matsuzaki K, Sata N.  Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells  PLoS One  2016  11(5):e0154542  PubMed ID: 27136922   DOI: 10.1371/journal.pone.0154542
12873  Liu X, Kwong A, Sihoe A, Chu KM.  Plasma miR-940 may serve as a novel biomarker for gastric cancer  Tumour Biol  2016  37(3):3589-97  PubMed ID: 26456959   DOI: 10.1007/s13277-015-4019-5
12874  Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H.  Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients  Gastric Cancer  2016  19(3):789-97.  PubMed ID: 26472729   DOI: 10.1007/s10120-015-0551-7
12913  Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E.  Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells  Oncotarget  2016  7(35):56855-56863  PubMed ID: 27487135   DOI: 10.18632/oncotarget.10869
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
12966  Tseng PC, Chen CL, Shan YS, Lin CF.  An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells  Oncotarget  2016  7(12):15150-60  PubMed ID: 26934444   DOI: 10.18632/oncotarget.7750
12968  Kimura A, Ogata K, Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Yanoma T, Suzuki M, Bai T, Oyama T, Kuwano H.  Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer  Oncotarget  2016  7(14):18415-23  PubMed ID: 26943774   DOI: 10.18632/oncotarget.7821
13474  Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.  α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15  Sci Rep  2016  6:25895  PubMed ID: 27181033   DOI: 10.1038/srep25895
14008  Thura M, Al-Aidaroos AQO, Yong WP, Kono K, Gupta A, Lin YB, Mimura K, Thiery JP, Goh BC, Tan P, Soo R, Hong CW, Wang L, Lin SJ, Chen E, Rha SY, Chung HC, Li J, Nandi S, Yuen HF, Zhang SD, Guan YK, So J, Zeng Q.  PRL3-zumab, a first-in-class humanized antibody for cancer therapy  JCI Insight  2016  1(9):e87607  PubMed ID: 27699276   DOI: 10.1172/jci.insight.87607
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14577  Sougleri IS, Papadakos KS, Zadik MP, Mavri-Vavagianni M, Mentis AF, Sgouras DN.  Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner  FEBS J  2016  283(2):206-20  PubMed ID: 26907789   DOI: 10.1111/febs.13592
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7206  Sawamura T, Tanaka T, Ishige H, Iizuka M, Murayama Y, Otsuji E, Ohkubo A, Ogura S, Yuasa H.  The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency.  Int J Mol Sci  2015  16:22415-24  PubMed ID: 26389895   DOI: 10.3390/ijms160922415
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13701  Fujimoto D, Ueda Y, Hirono Y, Goi T, Yamaguchi A.  PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway  Oncotarget  2015  6(33):34788-99  PubMed ID: 26431277   DOI: 10.18632/oncotarget.5858
13728  Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Hiraki S, Horiguchi H, Miyazaki H, Ono S, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K.  Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer  Ann Surg Oncol  2015  22 Suppl 3:S923-8  PubMed ID: 25986868   DOI: 10.1245/s10434-015-4594-0
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15000  Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S.  DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells  PLoS One  2015  10(12):e0145630  PubMed ID: 26695186   DOI: 10.1371/journal.pone.0145630
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
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5823  Yoneda A, Taniguchi K, Torashima Y, Susumu S, Kanetaka K, Kuroki T, Eguchi S.  The detection of gastric cancer cells in intraoperative peritoneal lavage using the reverse transcription--loop-mediated isothermal amplification method.  J Surg Res  2014  187(1):e1-6  PubMed ID: 24360119   DOI: 10.1016/j.jss.2013.01.001
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5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286   DOI: 10.1371/journal.pone.0102831
5832  Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, Kan S, Li Z, Zhang X, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration.  Br J Cancer  2014  110(7):1801-10  PubMed ID: 24548863   DOI: 10.1038/bjc.2014.70
6398  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629   DOI: 10.1016/j.bbrc.2014.06.007
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5835  Funakoshi Y, Mukohara T, Ekyalongo RC, Tomioka H, Kataoka Y, Shimono Y, Chayahara N, Toyoda M, Kiyota N, Fujiwara Y, Minami H.  Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.  Oncol Res. 2  2013  21(6):287-93  PubMed ID: 25198658   DOI: 10.3727/096504014X13946388748956
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5842  Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, Li Z, Wang L, Li J, Liu H, Qu X, Wang C.  Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.  Carcinogenesis  2013  34(5):974-83  PubMed ID: 23354307   DOI: 10.1093/carcin/bgt028
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9102  Toshiaki Tsuji, Mikihito Nakamori, Makoto Iwahashi, Masaki Nakamura, Toshiyasu Ojima, Takeshi Iida, Masahiro Katsuda, Keiji Hayata, Yasushi Ino, Tomoki Todo, Hiroki Yamaue  An Armed Oncolytic Herpes Simplex Virus Expressing thrombospondin-1 Has an Enhanced in Vivo Antitumor Effect Against Human Gastric Cancer  Int J Cancer  2013  132 (2), 485-94  PubMed ID: 22729516   DOI: 10.1002/ijc.27681
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17166  Tao Y, Guo Y, Liu W, Zhang J, Li X, Shen L, Ru Y, Xue Y, Zheng J, Liu X, Zhang J, Yao L.  AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells  Braz J Med Biol Res  2013  46(4):394-40  PubMed ID: 23558861   DOI: 10.1590/1414-431x20122211
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5864  Mika Hoshino, Hiroyuki Suzuki, Seigo Kashimura, Norio Kanzaki, Hiroshi Yaginuma, Takeo Hasegawa, Atsushi Yonechi, Jun Ohsugi, Mitsunori Higuchi, Yutaka Shio, Kazuya Ise, Mitsukazu Gotoh  BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction  Annals of Cancer Research and Therapy  2011  19:1-8   
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