CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1001 : MKN45]

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20600 Xie J, Fu L, Zhang J. Analysis of Influencing Factors on the Occurrence and Development of Gastric Cancer in High-Incidence Areas of Digestive Tract Tumors Based on High Methylation of GPX3 Gene. J Oncol 2022 3094881 PubMed ID: 35069731 DOI: 10.1155/2022/3094881

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16979 Ma J, Zhang C, Liang W, Li L, Du J, Pan C, Chen B, Chen Y, Wang Y. ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway Front Oncol 2022 12:802009 PubMed ID: 35251974 DOI: 10.3389/fonc.2022.802009

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20953 Sugezawa K, Morimoto M, Yamamoto M, Matsumi Y, Nakayama Y, Hara K, Uejima C, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Umekita Y, Fujiwara Y. GPX4 Regulates Tumor Cell Proliferation via Suppressing Ferroptosis and Exhibits Prognostic Significance in Gastric Cancer. Anticancer Res 2022 42(12):5719-5729 PubMed ID: 36456115 DOI: 10.21873/anticanres.16079

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13361 Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. Fitoterapia 2021 PubMed ID: 33246033 DOI: 10.1016/j.fitote.2020.104780

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20061 Iwamuro M, Shiraha H, Oyama A, Uchida D, Horiguchi S, Okada H. Laminin-411 and -511 Modulate the Proliferation, Adhesion, and Morphology of Gastric Cancer Cells. Cell Biochem Biophys 2021 PubMed ID: 33629255 DOI: 10.1007/s12013-021-00972-3

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14292 Hernández C, Toledo-Stuardo K, García-González P, Garrido-Tapia M, Kramm K, Rodríguez-Siza JA, Hermoso M, Ribeiro CH, Molina MC. Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4 Helicobacter 2021 e12812 PubMed ID: 33928707 DOI: 10.1111/hel.12812

14345 Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer Cancer Sci 2021 112(3):1026-1037. PubMed ID: 33404124 DOI: 10.1111/cas.14796

20224 Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E. Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer. Photodiagnosis Photodyn Ther 2021 PubMed ID: 34242818 DOI: 10.1016/j.pdpdt.2021.102420

20385 Ito K, Kitajima Y, Kai K, Matsufuji S, Yamada K, Egawa N, Kitagawa H, Okuyama K, Tanaka T, Noshiro H. Matrix metalloproteinase‑1 expression is regulated by HIF‑1‑dependent and epigenetic mechanisms and serves a tumor‑suppressive role in gastric cancer progression. Int J Oncol 2021 59(6) PubMed ID: 34738626 DOI: 10.3892/ijo.2021.5282

20415 Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T. Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells. Oncol Lett 2021 22(4):735 PubMed ID: 34466148 DOI: 10.3892/ol.2021.12996

20421 Reyna-Jeldes M, De la Fuente-Ortega E, Cerda D, Velázquez-Miranda E, Pinto K, Vázquez-Cuevas FG, Coddou C. Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines. Pharmaceutics 2021 13(8) PubMed ID: 34452195 DOI: 10.3390/pharmaceutics13081234

20520 Komatsu S, Imamura T, Kiuchi J, Takashima Y, Kamiya H, Ohashi T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Otsuji E. Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer. Am J Cancer Res 2021 11(12):6133-6146 PubMed ID: 35018247

16126 Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer Gastric Cancer 2021 24(6):1278-1292 PubMed ID: 34251542 DOI: 10.1007/s10120-021-01212-6

16803 Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H. Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells FEBS Open Bio 2021 11(5):1465-1475 PubMed ID: 33773069 DOI: 10.1002/2211-5463.13154

18207 Shigematsu N, Kawashiri T, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T. Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro Sci Rep 2020 10(1):6734 PubMed ID: 32317735 DOI: 10.1038/s41598-020-62738-w

11630 Nishimura T, Mitsunaga M, Ito K, Kobayashi H, Saruta M. Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT. Gastric Cancer 2020 23(1):82-94 PubMed ID: 31302791 DOI: 10.1007/s10120-019-00988-y

12041 Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S. FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer. Oncogenesis 2020 PubMed ID: 32029704 DOI: 10.1038/s41389-020-0190-7

13071 Tiffon C, Giraud J, Molina-Castro SE, Peru S, Seeneevassen L, Sifré E, Staedel C, Bessède E, Dubus P, Mégraud F, Lehours P, Martin OCB, Varon C. TAZ Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties. Cells 2020 PubMed ID: 32545795 DOI: 10.3390/cells9061462

13242 Uejima C, Morimoto M, Yamamoto M, Hara K, Miyauchi W, Sugezawa K, Tada Y, Tanio A, Kihara K, Matsunaga T, Tokuyasu N, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y. Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer. Anticancer Res 2020 40(10):5593-5600 PubMed ID: 32988883 DOI: 10.21873/anticanres.14572

13299 Wang J, Li Q, Cheng X, Zhang B, Lin J, Tang Y, Li F, Yang CS, Wang TC, Tu S. Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop. Onco Targets Ther 2020 PubMed ID: 33116635 DOI: 10.2147/OTT.S266506

13504 Baatar S, Bai T, Yokobori T, Gombodorj N, Nakazawa N, Ubukata Y, Kimura A, Kogure N, Sano A, Sohda M, Sakai M, Tumenjargal A, Ogata K, Kuwano H, Shirabe K, Saeki H. High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer Ann Surg Oncol 2020 27(11):4360-4368 PubMed ID: 32356270 DOI: 10.1245/s10434-020-08518-2

13600 Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K. p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers Biochem Biophys Res Commun 2020 529(3):582-589. PubMed ID: 32736677 DOI: 10.1016/j.bbrc.2020.05.168

13838 He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S. MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression FASEB J 2020 34(6):8544-8557 PubMed ID: 32356314 DOI: 10.1096/fj.201903217R

14297 Kumagai Y, Ohzawa H, Miyato H, Horie H, Hosoya Y, Lefor AK, Sata N, Kitayama J. Surgical Stress Increases Circulating Low-Density Neutrophils Which May Promote Tumor Recurrence J Surg Res 2020 246:52-61 PubMed ID: 31561178 DOI: 10.1016/j.jss.2019.08.022

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14844 Zhu S, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Que J, Garcia-Buitrago M, Zaika A, El-Rifai W. Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib Cancer Lett 2020 491:87-96 PubMed ID: 32735911 DOI: 10.1016/j.canlet.2020.07.014

14847 Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T. Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance Cancer Res 2020 80(16):3222-3235 PubMed ID: 32605995 DOI: 10.1158/0008-5472.CAN-19-3803

11202 Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E. Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer. Gastric Cancer 2019 PubMed ID: 30191346 DOI: 10.1007/s10120-018-0874-2

11360 Futami K, Kimoto M, Lim YWS, Hirao I. Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells. Mol Ther Nucleic Acids 2019 PubMed ID: 30594072 DOI: 10.1016/j.omtn.2018.11.011

11409 Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M. NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells. Oncogene 2019 PubMed ID: 30700829 DOI: 10.1038/s41388-019-0702-0

11448 Kim JH, Eom HJ, Lim G, Park S, Lee J, Nam S, Kim YH, Jeong JH. Differential effects, on oncogenic pathway signalling, by derivatives of the HNF4 α inhibitor BI6015. Br. J. Cancer 2019 PubMed ID: 30792535 DOI: 10.1038/s41416-018-0374-5

11456 Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H. Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation. Sci Rep 2019 PubMed ID: 30808977 DOI: 10.1038/s41598-019-39563-x

6418 Hevia MJ, Castro P, Pinto K1, Reyna-Jeldes M, Rodríguez-Tirado F, Robles-Planells C, Ramírez-Rivera S, Madariaga JA, Gutierrez F, López J, Barra M, De la Fuente-Ortega E, Bernal G, Coddou C. Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors. Front Pharmacol 2019 10:612 PubMed ID: 31249523 DOI: 10.3389/fphar.2019.00612

6419 Lin HJ, Jiang ZP, Lo HR, Feng CL, Chen CJ, Yang CY, Huang MZ, Wu HY, Chen YA, Chen Y, Chiu CH, Lai CH Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation. Front Immunol 2019 10:109 PubMed ID: 30863392 DOI: 10.3389/fimmu.2019.00109

11505 Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K. Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression. Biochem Biophys Rep 2019 18:100632 PubMed ID: 30993217 DOI: 10.1016/j.bbrep.2019.100632

11527 Ando H, Abu Lila AS, Fukushima M, Matsuoka R, Shimizu T, Okuhira K, Ishima Y, Huang CL, Wada H, Ishida T. A simplified method for manufacturing RNAi therapeutics for local administration. Int J Pharm 2019 PubMed ID: 31015002 DOI: 10.1016/j.ijpharm.2019.04.054

11613 Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W. Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells. Oncogene 2019 38(29):5805-5816 PubMed ID: 31235784 DOI: 10.1038/s41388-019-0843-1

11695 Shunsuke Odai, Hidehiro Ito, Toshiaki Kamachi Dendrimer porphyrins as the oxygen sensor for intracellular imaging to suppress interaction towards biological molecules Journal of Clinical Biochemistry and Nutrition 2019 PubMed ID: 31777418 DOI: 10.3164/jcbn.19-13

11733 Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E. Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. Int. J. Oncol. 2019 PubMed ID: 31432150 DOI: 10.3892/ijo.2019.4853

11850 Ando H, Fukushima M, Eshima K, Hasui T, Shimizu T, Ishima Y, Huang CL, Wada H, Ishida T. A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model. Cancer Med 2019 PubMed ID: 31609087 DOI: 10.1002/cam4.2598

6888 Nakayama T, Kobayashi T, Shimpei O, Fukuhara H, Namikawa T, Inoue K, Hanazaki K, Takahashi K, Nakajima M, Tanaka T, Ogura SI. Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway. Photodiagnosis Photodyn Ther 2019 28:10-17 PubMed ID: 31404677 DOI: 10.1016/j.pdpdt.2019.07.021

10444 Yuta Sugiyama, Erika Takahashi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura Inverse correlation between heme synthesis and the Warburg effect in cancer cells bioRxiv 2019 August 30 DOI: 10.1101/753079

11904 Gomaa A, Peng D, Chen Z, Soutto M, Abouelezz K, Corvalan A, El-Rifai W. Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. Sci Rep 2019 PubMed ID: 31740746 DOI: 10.1038/s41598-019-53174-6

11969 Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S. Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma. Sci Rep 2019 PubMed ID: 31873082 DOI: 10.1038/s41598-019-55465-4

12422 Miyagi A, Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T. Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents Biol Pharm Bull 2019 42(4):638-644. PubMed ID: 30930422 DOI: 10.1248/bpb.b18-00855

12423 Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W. Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1 Gastroenterology 2019 156(3):662-675.e7 PubMed ID: 30342037 DOI: 10.1053/j.gastro.2018.10.030

12424 Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T. Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect J Pharmacol Sci 2019 140(3):291-294 PubMed ID: 31377017 DOI: 10.1016/j.jphs.2019.05.009

10736 Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W. A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers. Clin. Cancer Res. 2018 24:1905-1916 PubMed ID: 29386219 DOI: 10.1158/1078-0432.CCR-17-1716

10744 Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang LJ, Chen SJ. HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. Gastric Cancer 2018 21(5):756-764 PubMed ID: 29417297 DOI: 10.1007/s10120-018-0801-6

10787 Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S. Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer 2018 118:972-984 PubMed ID: 29527007 DOI: 10.1038/s41416-018-0008-y

10831 Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T. A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research. Biol. Pharm. Bull. 2018 41:733-742 PubMed ID: 29709910 DOI: 10.1248/bpb.b17-00919

19424 Sato H, Hiraki M, Namba T, Egawa N, Baba K, Tanaka T, Noshiro H. Andrographolide induces degradation of mutant p53 via activation of Hsp70 Int J Oncol 2018 53(2):761-770 PubMed ID: 29845212 DOI: 10.3892/ijo.2018.4416

19425 Kanamaru R, Ohzawa H, Miyato H, Matsumoto S, Haruta H, Kurashina K, Saito S, Hosoya Y, Yamaguchi H, Yamashita H, Seto Y, Lefor AK, Sata N, Kitayama J. Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs) Sci Rep 2018 8(1):632 PubMed ID: 29330531 DOI: 10.1038/s41598-017-19091-2

11106 Guan SS, Wu CT, Chiu CY, Luo TY, Wu JY, Liao TZ, Liu SH. Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo. J Transl Med 2018 16(1):168 PubMed ID: 29921305 DOI: 10.1186/s12967-018-1550-3

11210 Nguyen PH, Touchefeu Y, Durand T, Aubert P, Duchalais E, Bruley des Varannes S, Varon C, Neunlist M, Matysiak-Budnik T. Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type. Tumour Biol. 2018 PubMed ID: 30207200 DOI: 10.1177/1010428318799028

11211 Osanai-Sasakawa A, Hosomi K, Sumitomo Y, Takizawa T, Tomura-Suruki S, Imaizumi M, Kasai N, Poh TW, Yamano K, Yong WP, Kono K, Nakamura S, Ishii T, Nakai R. An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models. Am J Cancer Res 2018 PubMed ID: 30210919

11219 Kato R, Iwamuro M, Shiraha H, Horiguchi S, Tanaka E, Matsumoto K, Ohyama A, Sawahara H, Nagahara T, Uchida D, Tsutsumi K, Okada H. Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties. Oncol Lett 2018 PubMed ID: 30250614 DOI: 10.3892/ol.2018.9301

11231 Wang Z, Qu H, Gong W, Liu A. Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer. IUBMB Life 2018 PubMed ID: 30281914 DOI: 10.1002/iub.1934

11282 Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H. The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis. Anticancer Res. 2018 PubMed ID: 30396946 DOI: 10.21873/anticanres.12982

11280 Ueta K, Otowa Y, Kakeji Y, Hirashima M. PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer. Anticancer Res. 2018 PubMed ID: 30396930 DOI: 10.21873/anticanres.12966

4190 Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M. Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma. Oncol. Rep. 2018 PubMed ID: 29138864 DOI: 10.3892/or.2017.6093

4301 Tsai WH, Yu KH, Huang YC, Lee CI. EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles. Int J Nanomedicine 2018 PubMed ID: 29445279 DOI: 10.2147/IJN.S148305

4302 Shin VY, Siu MT, Liu X, Ng EKO, Kwong A, Chu KM. MiR-92 suppresses proliferation and induces apoptosis by targeting EP4/Notch1 axis in gastric cancer. Oncotarget 2018 PubMed ID: 29849934 DOI: 10.18632/oncotarget.24819

4304 Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X. Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer. Oncol Lett 2018 PubMed ID: 29805691 DOI: 10.3892/ol.2018.8562

4313 Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E. Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma. Am J Cancer Res 2018 PubMed ID: 30662802

5801 Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z. Targeting IRF3 as a YAP agonist therapy against gastric cancer. J Exp Med 2018 215(2):699-718 PubMed ID: 29339449 DOI: 10.1084/jem.20171116

14263 Shao L, Chen Z, Peng D, Soutto M, Zhu S, Bates A, Zhang S, El-Rifai W. Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells Mol Cancer Res 2018 16(4):696-706 PubMed ID: 29453320 DOI: 10.1158/1541-7786.MCR-17-0655

14602 Kanamaru R, Ohzawa H, Miyato H, Yamaguchi H, Hosoya Y, Lefor AK, Sata N, Kitayama J. Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment J Vis Exp 2018 (138):58201 PubMed ID: 30124642 DOI: 10.3791/58201

14733 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E. Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma Carcinogenesis 2018 39(2):263-271 PubMed ID: 29228320 DOI: 10.1093/carcin/bgx139

14901 Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis Mol Cancer Res 2018 16(3):554-563 PubMed ID: 29330298 DOI: 10.1158/1541-7786.MCR-17-0393

9788 Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y. PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma. Gastric Cancer 2017 20:416-427 PubMed ID: 27517839 DOI: 10.1007/s10120-016-0627-z

10088 Tanaka S, Nagashima H, Uotani T, Graham DY, Yamaoka Y. Autophagy-related genes in Helicobacter pylori infection. Helicobacter 2017 22: PubMed ID: 28111844 DOI: 10.1111/hel.12376

10177 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Introduction of plasmids into gastric cancer cells by endoscopic ultrasound. Oncol Lett 2017 13:3127-3130 PubMed ID: 28521417 DOI: 10.3892/ol.2017.5836

10253 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. CCAAT/enhancer-binding protein α decreases the viability of gastric cancer cells. Oncol Lett 2017 13:4322-4326 PubMed ID: 28599433 DOI: 10.3892/ol.2017.5987

10258 Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y. ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer. Cancer Lett. 2017 398:52-61 PubMed ID: 28400336 DOI: 10.1016/j.canlet.2017.04.002

10328 Suzuki N, Nakagawa F, Takechi T. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett 2017 14:639-646 PubMed ID: 28693216 DOI: 10.3892/ol.2017.6258

10437 Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H. Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70. Oncol. Rep. 2017 38:1500-1506 PubMed ID: 28731175 DOI: 10.3892/or.2017.5844

10486 Shibaguchi H, Luo N, Shirasu N, Kuroki M, Kuroki M. Enhancement of antitumor activity by using a fully human gene encoding a single-chain fragmented antibody specific for carcinoembryonic antigen. Onco Targets Ther 2017 10:3979-3990 PubMed ID: 28860806 DOI: 10.2147/OTT.S140174

10652 Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S. Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F. Oncotarget 2017 8:97371-97383 PubMed ID: 29228617 DOI: 10.18632/oncotarget.22126

10686 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E. Low plasma levels of miR-101 are associated with tumor progression in gastric cancer. Oncotarget 2017 8:106538-106550 PubMed ID: 29290969 DOI: 10.18632/oncotarget.20860

10722 Lan KH, Lee WP, Wang YS, Liao SX, Lan KH. Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells. Oncotarget 2017 8:113460-113471 PubMed ID: 29371922 DOI: 10.18632/oncotarget.23050

10955 Kitayama J, Ishigami H, Yamaguchi H, Yamada J, Soma D, Miyato H, Kamei T, Lefor AK, Sata N. Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model Pleura Peritoneum 2017 2:95-102 PubMed ID: 30911637 DOI: 10.1515/pp-2017-0002

5804 Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26 Oncology Letters 2017 13(1):215-221 PubMed ID: 28123544 DOI: 10.3892/ol.2016.5386

5806 Shiroki T et al Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism. Cancer Sci 2017 108(5):931-940 PubMed ID: 28235245 DOI: 10.1111/cas.13211

13680 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Proliferation and motility of hepatocellular, pancreatic and gastric cancer cells grown in a medium without glucose and arginine, but with galactose and ornithine Oncol Lett 2017 13(3):1276-1280 PubMed ID: 28454246 DOI: 10.3892/ol.2017.5568

14097 Kimura A, Ogata K, Altan B, Yokobori T, Mochiki E, Yanai M, Kogure N, Yanoma T, Suzuki M, Bai T, Kuwano H. Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis World J Gastroenterol 2017 23(42):7541-7550 PubMed ID: 29204054 DOI: 10.3748/wjg.v23.i42.7541

14358 Garrido-Tapia M, Hernández CJ, Ascui G, Kramm K, Morales M, Ga Rate V, Zúñiga R, Bustamante M, Aguillón JC, Catala N D, Ribeiro CH, Molina MAC. STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells Immunobiology 2017 222(11):1043-1051 PubMed ID: 28578917 DOI: 10.1016/j.imbio.2017.05.009

14615 Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K. Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer Oncotarget 2017 8(64):107666-107677 PubMed ID: 29296196 DOI: 10.18632/oncotarget.22587

14619 Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E. Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer Oncotarget 2017 8(60):101394-101405 PubMed ID: 29254173 DOI: 10.18632/oncotarget.20736

14663 Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M, Nakajima Y. Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer Oncol Lett 2017 13(5):3131-3138 PubMed ID: 28521418 DOI: 10.3892/ol.2017.5806

14735 Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS. Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil Sci Rep 2017 7(1):2262 PubMed ID: 28536445 DOI: 10.1038/s41598-017-02548-9

14737 Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H. Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines Sci Rep 2017 7(1):11127 PubMed ID: 28894280 DOI: 10.1038/s41598-017-11769-x

14746 Chen Z, Hu T, Zhu S, Mukaisho K, El-Rifai W, Peng DF. Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer Oncotarget 2017 8(33):54345-54356 PubMed ID: 28903346 DOI: 10.18632/oncotarget.17527

14747 Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jiménez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, Graham DY, Yamaoka Y. Interleukin-17C in Human Helicobacter pylori Gastritis Infect Immun 2017 85(10):e00389-17 PubMed ID: 28739826 DOI: 10.1128/IAI.00389-17

7297 Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W. Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis. Oncogene 2016 35:1847-56 PubMed ID: 26119931 DOI: 10.1038/onc.2015.250

9517 Lin CJ, Liao WC, Lin HJ, Hsu YM, Lin CL, Chen YA, Feng CL, Chen CJ, Kao MC, Lai CH, Kao CH. Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies. PLoS ONE 2016 11:e0146432 PubMed ID: 26730715 DOI: 10.1371/journal.pone.0146432

9541 Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H. Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms. BMC Cancer 2016 16:37 PubMed ID: 26810644 DOI: 10.1186/s12885-016-2072-0

9542 Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H. Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia. Int. J. Oncol. 2016 48:1379-90 PubMed ID: 26820502 DOI: 10.3892/ijo.2016.3359

9548 Mu J, Liu T, Jiang L, Wu X, Cao Y, Li M, Dong Q, Liu Y, Xu H. The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells. J Cancer 2016 7:453-61 PubMed ID: 26918059 DOI: 10.7150/jca.13548

9625 Shiraishi K, Mimura K, Kua LF, Koh V, Siang LK, Nakajima S, Fujii H, Shabbir A, Yong WP, So J, Takenoshita S, Kono K. Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility. J. Gastroenterol. 2016 51:1101-1111 PubMed ID: 27002316 DOI: 10.1007/s00535-016-1197-x

9652 Lan H, Tang Z, Jin H, Sun Y. Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Sci Rep 2016 6:24218 PubMed ID: 27063292 DOI: 10.1038/srep24218

9672 Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 2016 35:5388-5399 PubMed ID: 27109105 DOI: 10.1038/onc.2016.76

9760 Zhou J, You W, Sun G, Li Y, Chen B, Ai J, Jiang H. The Marine-Derived Oligosaccharide Sulfate MS80, a Novel Transforming Growth Factor β1 Inhibitor, Reverses Epithelial Mesenchymal Transition Induced by Transforming Growth Factor-β1 and Suppresses Tumor Metastasis. J. Pharmacol. Exp. Ther. 2016 359:54-61 PubMed ID: 27432893 DOI: 10.1124/jpet.116.234799

9795 Xie P, Fujii I, Zhao J, Shinohara M, Matsukura M. A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway. Int. J. Oncol. 2016 49:1561-1568 PubMed ID: 27633119 DOI: 10.3892/ijo.2016.3658

9902 Hayashi N, Kataoka H, Yano S, Kikuchi JI, Tanaka M, Nishie H, Kinoshita Y, Hatano M, Nomoto A, Ogawa A, Inoue M, Mizoshita T, Shimura T, Mori Y, Kubota E, Tanida S, Joh T. Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer. Anticancer Res. 2016 36:6005-6009 PubMed ID: 27793927 DOI: 10.21873/anticanres.11189

9919 Chang HR, Nam S, Lee J, Kim JH, Jung HR, Park HS, Park S, Ahn YZ, Huh I, Balch C, Ku JL, Powis G, Park T, Jeong JH, Kim YH. Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer. Oncotarget 2016 7:81435-81451 PubMed ID: 27806312 DOI: 10.18632/oncotarget.12963

9928 Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 2016 113:E7535-E7544 PubMed ID: 27821766 DOI: 10.1073/pnas.1608585113

3733 Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S. Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget 2016 7(41):67251-67265 PubMed ID: 27572307 DOI: 10.18632/oncotarget.11625

5808 Hughes PE et al In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models. Mol Cancer Ther 2016 15(7):1568-79 PubMed ID: 27196782 DOI: 10.1158/1535-7163.MCT-15-0871

5809 Ninomiya K et al Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines. J Nat Med 2016 70(3):435-51 PubMed ID: 27178360 DOI: 10.1007/s11418-016-0998-9

5810 Kitagawa N et al The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines. Int J Mol Sci 2016 17(12). pii: E1979 PubMed ID: 27898032 DOI: 10.3390/ijms17121979

5813 Costa AM　etal Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways. J Infect Dis 2016 213(11):1767-76 PubMed ID: 26802142 DOI: 10.1093/infdis/jiw031

12613 Takeda S, Tanigawa T, Watanabe T, Tatsuwaki H, Nadatani Y, Otani K, Nagami Y, Tanaka F, Kamata N, Yamagami H, Shiba M, Tominaga K, Fujiwara Y, Muguruma K, Ohira M, Hirakawa K, Arakawa T. Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma J Gastroenterol Hepatol 2016 31(2):376-83 PubMed ID: 26250887 DOI: 10.1111/jgh.13079

12633 Hu W, Zhang Y, Jiang Z, Wang L, Li J, Chen S, Dai N, Si J. The tumor promoting roles of erythropoietin/erythropoietin receptor signaling pathway in gastric cancer Tumour Biol 2016 ;37(8):11523-33 PubMed ID: 27086036 DOI: 10.1007/s13277-016-5053-7

12656 Kitayama J, Yamaguchi H, Ishigami H, Matsuzaki K, Sata N. Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells PLoS One 2016 11(5):e0154542 PubMed ID: 27136922 DOI: 10.1371/journal.pone.0154542

12873 Liu X, Kwong A, Sihoe A, Chu KM. Plasma miR-940 may serve as a novel biomarker for gastric cancer Tumour Biol 2016 37(3):3589-97 PubMed ID: 26456959 DOI: 10.1007/s13277-015-4019-5

12874 Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients Gastric Cancer 2016 19(3):789-97. PubMed ID: 26472729 DOI: 10.1007/s10120-015-0551-7

12913 Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E. Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells Oncotarget 2016 7(35):56855-56863 PubMed ID: 27487135 DOI: 10.18632/oncotarget.10869

12951 Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H. Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer Oncol Lett 2016 11(2):1026-1034. PubMed ID: 26893686 DOI: 10.3892/ol.2015.4011

12966 Tseng PC, Chen CL, Shan YS, Lin CF. An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells Oncotarget 2016 7(12):15150-60 PubMed ID: 26934444 DOI: 10.18632/oncotarget.7750

12968 Kimura A, Ogata K, Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Yanoma T, Suzuki M, Bai T, Oyama T, Kuwano H. Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer Oncotarget 2016 7(14):18415-23 PubMed ID: 26943774 DOI: 10.18632/oncotarget.7821

13474 Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15 Sci Rep 2016 6:25895 PubMed ID: 27181033 DOI: 10.1038/srep25895

14008 Thura M, Al-Aidaroos AQO, Yong WP, Kono K, Gupta A, Lin YB, Mimura K, Thiery JP, Goh BC, Tan P, Soo R, Hong CW, Wang L, Lin SJ, Chen E, Rha SY, Chung HC, Li J, Nandi S, Yuen HF, Zhang SD, Guan YK, So J, Zeng Q. PRL3-zumab, a first-in-class humanized antibody for cancer therapy JCI Insight 2016 1(9):e87607 PubMed ID: 27699276 DOI: 10.1172/jci.insight.87607

14159 Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR. CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions Cancer Discov 2016 ;6(8):900-13 PubMed ID: 27260157 DOI: 10.1158/2159-8290.CD-16-0178

14577 Sougleri IS, Papadakos KS, Zadik MP, Mavri-Vavagianni M, Mentis AF, Sgouras DN. Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner FEBS J 2016 283(2):206-20 PubMed ID: 26907789 DOI: 10.1111/febs.13592

17834 Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T. High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime Sci Rep 2015 5:10657 PubMed ID: 26065366 DOI: 10.1038/srep10657

7097 Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S. Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia. PLoS ONE 2015 10:e0146026 PubMed ID: 26717566 DOI: 10.1371/journal.pone.0146026

7206 Sawamura T, Tanaka T, Ishige H, Iizuka M, Murayama Y, Otsuji E, Ohkubo A, Ogura S, Yuasa H. The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency. Int J Mol Sci 2015 16:22415-24 PubMed ID: 26389895 DOI: 10.3390/ijms160922415

7233 Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H. Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation. Sci Rep 2015 5:13474 PubMed ID: 26310847 DOI: 10.1038/srep13474

7277 Yoshimoto M, Higaki K, Nanba E, Ikeguchi M. Anti-Proliferation Activity of Fucoidan in MKN45 Gastric Cancer Cells and Downregulation of Phosphorylated ASK1, a Cell Cycle-Regulated Kinase. Yonago Acta Med 2015 58:1-7 PubMed ID: 26190891

7334 Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H. Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. Sci Rep 2015 5:10455 PubMed ID: 25994878 DOI: 10.1038/srep10455

7470 Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R, Sakimura E, Shinden Y, Iguchi T, Eguchi H, Oba Y, Hoka S, Mimori K. The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer. Ann. Surg. Oncol. 2015 22 Suppl 3:S1436-43 PubMed ID: 25707493 DOI: 10.1245/s10434-015-4418-2

7512 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA. Int. J. Oncol. 2015 46:1018-24 PubMed ID: 25586465 DOI: 10.3892/ijo.2015.2830

7529 H Niwa, Y Maeyama, S Kikuchi, H Kawaguchi, T Daimon, Y Furuya, H Ito, N Mizuno, M Otsu, H Yasuhara, M Sasako Impacts of Cancer-Associated Stromal Cells on Growth of Human Gastric Cancer Cell Lines. Cancer Cell & Microenvironment 2015 2:e921 DOI: 10.14800/ccm.921

18974 Jun Yu, Wai K. Leung 10 Loss of Cyclin D2 Expression in Gastric Cancer Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma 2015 161-168 DOI: 10.1016/s1874-5784(05)80072-8

5819 Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K. CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Cancer Med 2015 4(9):1322-33 PubMed ID: 26077800 DOI: 10.1002/cam4.478

5820 Torii K et al Effectiveness of plasma treatment on gastric cancer cells. Gastric Cancer 2015 18(3):635-43 PubMed ID: 24997570 DOI: 10.1007/s10120-014-0395-6

13701 Fujimoto D, Ueda Y, Hirono Y, Goi T, Yamaguchi A. PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway Oncotarget 2015 6(33):34788-99 PubMed ID: 26431277 DOI: 10.18632/oncotarget.5858

13728 Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Hiraki S, Horiguchi H, Miyazaki H, Ono S, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K. Theranostic Photosensitive Nanoparticles for Lymph Node Metastasis of Gastric Cancer Ann Surg Oncol 2015 22 Suppl 3:S923-8 PubMed ID: 25986868 DOI: 10.1245/s10434-015-4594-0

14977 Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y. CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence J Surg Oncol 2015 112(6):622-8 PubMed ID: 26416034 DOI: 10.1002/jso.24056

15000 Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S. DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells PLoS One 2015 10(12):e0145630 PubMed ID: 26695186 DOI: 10.1371/journal.pone.0145630

15037 Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M. Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients Carcinogenesis 2015 36(12):1474-83 PubMed ID: 26420253 DOI: 10.1093/carcin/bgv139

15179 Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T. 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells Int J Oncol 2015 46(1):63-70 PubMed ID: 25310623 DOI: 10.3892/ijo.2014.2693

17451 Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Hiramoto H, Hamada J, Shoda K, Kawaguchi T, Hirajima S, Nagata H, Fujiwara H, Okamoto K, Otsuji E. Increase in peritoneal recurrence induced by intraoperative hemorrhage in gastrectomy Ann Surg Oncol 2015 22(3):758-64 PubMed ID: 25201501 DOI: 10.1245/s10434-014-4060-4

18176 Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. HDM2 regulation by AURKA promotes cell survival in gastric cancer Clin Cancer Res 2014 20(1):76-86 PubMed ID: 24240108 DOI: 10.1158/1078-0432.CCR-13-1187

18179 Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses Elife 2014 3:e04177 PubMed ID: 25149452 DOI: 10.7554/eLife.04177

18932 Kang W, Tong JH, Chan AW, Zhao J, Dong Y, Wang S, Yang W, Sin FM, Ng SS, Yu J, Cheng AS, To KF. Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma J Transl Med 2014 12:80 PubMed ID: 24674326 DOI: 10.1186/1479-5876-12-80

18949 Murai T, Yamada S, Fuchs BC, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Tanabe KK, Kodera Y. Epithelial-to-mesenchymal transition predicts prognosis in clinical gastric cancer J Surg Oncol 2014 109(7):684-9 PubMed ID: 24453058 DOI: 10.1002/jso.23564

19060 Tawada M, Hayashi S, Ikegame Y, Nakashima S, Yoshida K. Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow Oncol Rep 2014 32(6):2359-64 PubMed ID: 25242215 DOI: 10.3892/or.2014.3499

5822 Montiel-Eulefi, E. Jara, F. Toro, C. Garcés, M.& Leal, P. Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4 Loaded PLA Nanoparticles on MKN-45 Gastric Adenocarcinoma Cell Line Int J Morphol 2014 32(1):61-69

5823 Yoneda A, Taniguchi K, Torashima Y, Susumu S, Kanetaka K, Kuroki T, Eguchi S. The detection of gastric cancer cells in intraoperative peritoneal lavage using the reverse transcription--loop-mediated isothermal amplification method. J Surg Res 2014 187(1):e1-6 PubMed ID: 24360119 DOI: 10.1016/j.jss.2013.01.001

5824 Shen Q, Tang W, Sun J, Feng L, Jin H, Wang X. Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer. Am J Transl Res 2014 6(5):538-47 PubMed ID: 25360218

5830 Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS One 2014 9(7):e102831 PubMed ID: 25033286 DOI: 10.1371/journal.pone.0102831

5832 Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, Kan S, Li Z, Zhang X, Wang L, Li J, Liu H, Qu X, Wang C. Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration. Br J Cancer 2014 110(7):1801-10 PubMed ID: 24548863 DOI: 10.1038/bjc.2014.70

6398 Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S Eph receptor A10 has a potential as a target for a prostate cancer therapy. Biochem Biophys Res Commun 2014 450(1):545-9 PubMed ID: 24924629 DOI: 10.1016/j.bbrc.2014.06.007

14396 Zhang Z, Miao L, Wu X, Liu G, Peng Y, Xin X, Jiao B, Kong X. Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling J Cancer 2014 5(5):382-9 PubMed ID: 24799956 DOI: 10.7150/jca.8024

15817 Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G. A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines PLoS One 2014 9(2):e90155 PubMed ID: 24587255 DOI: 10.1371/journal.pone.0090155

15826 Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Watanabe T. CD90+ mesothelial-like cells in peritoneal fluid promote peritoneal metastasis by forming a tumor permissive microenvironment PLoS One 2014 9(1):e86516 PubMed ID: 24466130 DOI: 10.1371/journal.pone.0086516

15903 Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T. Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin Cancer Biol Ther 2014 15(1):81-8 PubMed ID: 24149371 DOI: 10.4161/cbt.26610

15904 E Montiel-Eulefi, F Jara, C Toro, M Garcés, P Leal Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4 Loaded PLA Nanoparticles on MKN-45 Gastric Adenocarcinoma Cell Line International Journal of Morphology 2014 32:61-69 DOI: 10.4067/s0717-95022014000100011

15998 Tsujimoto H, Morimoto Y, Takahata R, Nomura S, Yoshida K, Horiguchi H, Hiraki S, Ono S, Miyazaki H, Saito D, Hara I, Ozeki E, Yamamoto J, Hase K. Photodynamic therapy using nanoparticle loaded with indocyanine green for experimental peritoneal dissemination of gastric cancer Cancer Sci 2014 105(12):1626-30 PubMed ID: 25287817 DOI: 10.1111/cas.12553

16650 Otsuki T, Fujimoto D, Hirono Y, Goi T, Yamaguchi A. Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer Int J Oncol 2014 45(6):2287-94 PubMed ID: 25231630 DOI: 10.3892/ijo.2014.2651

17126 Migita K, Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Ito M, Nishiwada S, Nakajima Y. Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer Gastric Cancer 2014 17(4):601-9 PubMed ID: 24292229 DOI: 10.1007/s10120-013-0318-y

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18960 Matsuda K, Yamauchi K, Matsumoto T, Sano K, Yamaoka Y, Ota H. Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and Scand J Gastroenterol 2008 43(1):25-33 PubMed ID: 18938748 DOI: 10.1080/00365520701579795

18966 Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Okada Y, Takeyama H, Manabe T. Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines J Surg Res 2008 148(2):197-204 PubMed ID: 18395750 DOI: 10.1016/j.jss.2007.08.014

18978 Yamauchi K, Choi IJ, Lu H, Ogiwara H, Graham DY, Yamaoka Y. Regulation of IL-18 in Helicobacter pylori infection J Immunol 2008 180(2):1207-16 PubMed ID: 18178861 DOI: 10.4049/jimmunol.180.2.1207

3574 Tanaka F, Tominaga K, Shiota M, Ochi M, Kuwamura H, Tanigawa T, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Iwao H, Arakawa T. Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity. Cancer Gene Ther. 2008 15(1):51-9 PubMed ID: 17992202 DOI: 10.1038/sj.cgt.7701104

5885 Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, Zeng Z, Shah M, Christensen JG, Rosen N, Solit DB, Weiser MR. HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol Cancer Ther 2008 7(11):3499-508 PubMed ID: 18974395 DOI: 10.1158/1535-7163.MCT-08-0374

5886 Inoue M, Matsumoto S, Saito H, Tsujitani S, Ikeguchi M. Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer. Int J Cancer. 2008 123(11):2696-701 PubMed ID: 18798274 DOI: 10.1002/ijc.23867

5887 Hara M, Nakanishi H, Tsujimura K, Matsui M, Yatabe Y, Manabe T, Tatematsu M. Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. Cancer Sci 2008 99(7):1471-8 PubMed ID: 18422755 DOI: 10.1111/j.1349-7006.2008.00821.x

5889 Sakurai Y, Yoshida I, Kamoshida S, Inaba K, Isogaki J, Komori Y, Uyama I, Tsutsumi Y. Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts. Anticancer Res 2008 28(3A):1593-602 PubMed ID: 18630517

5891 Tozawa K, Oshima T, Kobayashi T, Yamamoto N, Hayashi C, Matsumoto T, Miwa H Oxaliplatin in treatment of the cisplatin-resistant MKN45 cell line of gastric cancer. Anticancer Res 2008 28(4B):2087-92 PubMed ID: 18751380

6139 Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer 2008 122(5):1040-6 PubMed ID: 17957782 DOI: 10.1002/ijc.23181

7935 Han Z, Wu K, Shen H, Li C, Han S, Hong L, Shi Y, Liu N, Guo C, Xue Y, Qiao T, Fan D. Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation. Dig Dis Sci 2008 53(7):1801-10 PubMed ID: 18379876 DOI: 10.1007/s10620-007-9824-2

13878 Tanaka Y, Goto K, Matsumoto Y, Ueoka R. Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis Int J Pharm 2008 359(1-2):264-71 PubMed ID: 18511224 DOI: 10.1016/j.ijpharm.2008.03.045

1962 Shimokawa O, Matsui H, Nagano Y, Kaneko T, Shibahara T, Nakahara A, Hyodo I, Yanaka A, Majima HJ, Nakamura Y, Matsuzaki Y. Neoplastic transformation and induction of H+,K+ -adenosine triphosphatase by N-methyl-N'-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line In Vitro Cell Dev Biol Anim 2008 44(1-2):26-30 PubMed ID: 18034283 DOI: 10.1007/s11626-007-9067-8

18621 Lu H, Wu JY, Beswick EJ, Ohno T, Odenbreit S, Haas R, Reyes VE, Kita M, Graham DY, Yamaoka Y. Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains J Biol Chem 2007 282(9):6242-54 PubMed ID: 17202133 DOI: 10.1074/jbc.M611178200

18853 Carl-McGrath S, Ebert MP, Lendeckel U, Röcken C. Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread Cancer Biol Ther 2007 6(8):1218-26 PubMed ID: 18059164 DOI: 10.4161/cbt.6.8.4412

18924 Osaki T, Saito H, Yoshikawa T, Matsumoto S, Tatebe S, Tsujitani S, Ikeguchi M. Decreased NKG2D expression on CD8+ T cell is involved in immune evasion in patients with gastric cancer Clin Cancer Res 2007 13(2 Pt 1):382-7 PubMed ID: 17255258 DOI: 10.1158/1078-0432.CCR-06-1454

18969 Takahashi H, Murai Y, Tsuneyama K, Nomoto K, Okada E, Fujita H, Takano Y. High labeling indices of cdc25B is linked to progression of gastric cancers and associated with a poor prognosis Appl Immunohistochem Mol Morphol 2007 15(3):267-72 PubMed ID: 17721270 DOI: 10.1097/01.pai.0000213120.58472.57

19035 Chan MW, Wong CY, Cheng AS, Chan VY, Chan KK, To KF, Chan FK, Sung JJ, Leung WK. Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells Oncol Rep 2007 18(6):1557-62 PubMed ID: 17982644

19342 Ning X, Sun S, Hong L, Liang J, Liu L, Han S, Liu Z, Shi Y, Li Y, Gong W, Zhang S, Chen Y, Guo X, Cheng Y, Wu K, Fan D. Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer Mol Cancer Res 2007 5(12):1254-62 PubMed ID: 18171983 DOI: 10.1158/1541-7786.MCR-06-0426

5892 Setoyama T, Natsugoe S, Okumura H, Matsumoto M, Uchikado Y, Aikou T. Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer. Br J Surg 2007 94(8):984-91 PubMed ID: 17410638 DOI: 10.1002/bjs.5717

5893 Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T. Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer. Clin Exp Metastasis 2007 24(3):179-89 PubMed ID: 17487561 DOI: 10.1007/s10585-007-9067-9

5895 Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A. Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14. Cancer Res 2007 67(18):8682-9 PubMed ID: 17875708 DOI: 10.1158/0008-5472.CAN-07-1586

15600 Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK. Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer Br J Cancer 2007 97(7):895-901 PubMed ID: 17848950 DOI: 10.1038/sj.bjc.6603968

16154 Higashiyama M, Ito T, Tanaka E, Shimada Y. Prognostic significance of osteopontin expression in human gastric carcinoma Ann Surg Oncol 2007 14(12):3419-27 PubMed ID: 17896150 DOI: 10.1245/s10434-007-9564-8

3430 Wu, Jeng Yih, Lu, Hong, Sun, Yubo, Graham, David Y, Cheung, Herman S, Yamaoka, Yoshio Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression. Cancer Res 2006 66:5111-20 PubMed ID: 16707434 DOI: 10.1158/0008-5472.CAN-06-0383

18448 Yamashita H, Kitayama J, Shida D, Yamaguchi H, Mori K, Osada M, Aoki S, Yatomi Y, Takuwa Y, Nagawa H. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation J Surg Res 2006 130(1):80-7 PubMed ID: 16183075 DOI: 10.1016/j.jss.2005.08.004

8916 Hitoshi KAWAMOTO, Yasunari MIKI, Takayuki KIMURA, Katsunori TANAKA, Tsuyoshi NAKAGAWA, Makoto KAWAMUKAI and Hideyuki MATSUDA Effects of fucoidan from Mozuku on human stomach cell lines Food Sci Technol Res 2006 12:218-222 DOI: 10.3136/fstr.12.218

18965 Koga Y, Kitajima Y, Miyoshi A, Sato K, Sato S, Miyazaki K. The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer J Gastroenterol 2006 41(2):133-9 PubMed ID: 16568372 DOI: 10.1007/s00535-005-1732-7

19059 Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MC, Wang J, He H, Jiang SH, Sun YW, Yu LF, Yuen ST, Kung HF, Wong BC. Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers Gastroenterology 2006 131(6):1835-43 PubMed ID: 17087954 DOI: 10.1053/j.gastro.2006.09.050

5897 Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M. Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma. Oncology 2006 70(2):126-33 PubMed ID: 16645325 DOI: 10.1159/000093003

5898 Handa O, Yoshida N, Fujita N, Tanaka Y, Ueda M, Takagi T, Kokura S, Naito Y, Okanoue T, Yoshikawa T. Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors. Inflamm Res 2006 55(11):476-80 PubMed ID: 17122965 DOI: 10.1007/s00011-006-6056-4

5899 Yokoyama H, Ikehara Y, Kodera Y, Ikehara S, Yatabe Y, Mochizuki Y, Koike M, Fujiwara M, Nakao A, Tatematsu M, Nakanishi H. Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. Br J Cancer 2006 95(11):1504-13 PubMed ID: 17088902 DOI: 10.1038/sj.bjc.6603459

5900 Xia HH, He H, De Wang J, Gu Q, Lin MC, Zou B, Yu LF, Sun YW, Chan AO, Kung HF, Wong BC. Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. Cancer Lett 2006 241(2):268-74 PubMed ID: 16337741 DOI: 10.1016/j.canlet.2005.10.031

5904 Matsumoto S, Saito H, Tsujitani S, Ikeguchi M. Allogeneic gastric cancer cell-dendritic cell hybrids induce tumor antigen (carcinoembryonic antigen) specific CD8(+) T cells. Cancer Immunol Immunother 2006 55(2):131-9 PubMed ID: 15891883 DOI: 10.1007/s00262-005-0684-3

5907 Sako A, Kitayama J, Shida D, Suzuki R, Sakai T, Ohta H, Nagawa H. Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites. J Surg Res 2006 130(1):94-101 PubMed ID: 16171822 DOI: 10.1016/j.jss.2005.08.007

3109 Honjo, Soichiro, Osaki, Mitsuhiko, Ardyanto, Tonang Dwi, Hiramatsu, Toshiki, Maeta, Noritaka, Ito, Hisao COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. DNA Cell Biol 2005 24:141-7 PubMed ID: 15767780 DOI: 10.1089/dna.2005.24.141

3167 Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol Pharm Bull 2005 28:574-9 PubMed ID: 15802789 DOI: 10.1248/bpb.28.574

3375 Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M. p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res. 2005 65:10822-9 PubMed ID: 16322228 DOI: 10.1158/0008-5472.CAN-05-0777

3867 Nakagiri A, Kato S, Takeuchi K. Irritative action of alcoholic beverages in rat stomachs: a comparative study with ethanol. Inflammopharmacology 2005 13(1-3):273-9 PubMed ID: 16259746 DOI: 10.1163/156856005774423845

5908 Ohashi N, Kodera Y, Nakanishi H, Yokoyama H, Fujiwara M, Koike M, Hibi K, Nakao A, Tatematsu M. Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice. nt J Oncol 2005 27(3):637-44 PubMed ID: 16077911

5911 Kanzaki N, Terashima M, Kashimura S, Hoshino M, Ohtani S, Matsuyama S, Hoshino Y, Kogure M, Oshibe I, Endo H, Saito T, Yaginuma H, Gotoh M, Ohto H. Understanding the response of dendritic cells to activation by streptococcal preparation OK-432. Anticancer Res 2005 25(6B):4231-8 PubMed ID: 16309221

5913 Kakinuma N, Sato M, Yamada T, Kohu K, Nakajima M, Akiyama T, Ohwada S, Shibanaka Y. Cloning of novel LERGU mRNAs in GPR30 3' untranslated region and detection of 2 bp-deletion polymorphism in gastric cancer. Cancer Sci 2005 96(3):191-6 PubMed ID: 15771623 DOI: 10.1111/j.1349-7006.2005.00031.x

5914 Xia HH, Lam SK, Chan AO, Lin MC, Kung HF, Ogura K, Berg DE, Wong BC. Macrophage migration inhibitory factor stimulated by Helicobacter pylori increases proliferation of gastric epithelial cells. World J Gastroenterol 2005 11(13):1946-50 PubMed ID: 15800984 DOI: 10.3748/wjg.v11.i13.1946

5917 Endo K, Kohnoe S, Tsujita E, Watanabe A, Nakashima H, Baba H, Maehara Y. Modulation of anti-apoptosis by endogenous IAP expression in MKN45 human gastric cancer cells. Anticancer Res 2005 25(4):2713-7 PubMed ID: 16080516

5919 Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines Yonago Acta medica 2005 48:7–16

5920 Chang YJ, Wu MS, Lin JT, Chen CC. Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation. J Immunol 2005 175(12):8242-52 PubMed ID: 16339564 DOI: 10.4049/jimmunol.175.12.8242

6449 Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M. Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping. World J Gastroenterol 2005 11(33):5129-35 PubMed ID: 16127741 DOI: 10.3748/wjg.v11.i33.5129

3596 Fujiwara H, Kubota T, Amaike H, Inada S, Takashima K, Atsuji K, Yoshimura M, Maemondo M, Narumi K, Nukiwa T, Matsumoto K, Nakamura T, Hagiwara A, Yamagishi H. Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression. Cancer Gene Ther 2005 12(2):206-16 PubMed ID: 15486556 DOI: 10.1038/sj.cgt.7700782

12834 Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y. Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori Mol Biol Cell 2005 16(10):4954-66. PubMed ID: 16030249 DOI: 10.1091/mbc.e05-05-0426

13836 Murai Y, Hayashi S, Takahashi H, Tsuneyama K, Takano Y. Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines Pathol Res Pract 2005 201(2):109-15 PubMed ID: 15901131 DOI: 10.1016/j.prp.2005.01.002

16808 Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Röcken C. The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer Int J Oncol 2005 26(1):17-24 PubMed ID: 15586220

17369 Pak H, Teixeira F, Punjabi S, Nicholson M, Van Rij A. Small bowel obstruction in a young woman Gut 2005 927, 1050 PubMed ID: 15951535 DOI: 10.1136/gut.2004.058032

2807 Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells. Exp Cell Res 2004 301:168-78 PubMed ID: 15530853 DOI: 10.1016/j.yexcr.2004.08.008

3104 Osaki, Mitsuhiko, Kase, Satoru, Adachi, Keiko, Takeda, Ami, Hashimoto, Kiyoshi, Ito, Hisao Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J Cancer Res Clin Oncol 2004 130:8-14 PubMed ID: 14605879 DOI: 10.1007/s00432-003-0505-z

2921 Ishihara, Shunji, Rumi, Mohammad Azharul Karim, Kadowaki, Yasunori, Ortega-Cava, Cesar Francisco, Yuki, Takafumi, Yoshino, Nagisa, Miyaoka, Youichi, Kazumori, Hideaki, Ishimura, Norihisa, Amano, Yuji, Kinoshita, Yoshikazu Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol 2004 173:1406-16 PubMed ID: 15240737 DOI: 10.4049/jimmunol.173.2.1406

3105 Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma. Eur J Clin Invest 2004 34:605-12 PubMed ID: 15379759 DOI: 10.1111/j.1365-2362.2004.01401.x

18758 Leung WK, Bai AH, Chan VY, Yu J, Chan MW, To KF, Wu JR, Chan KK, Fu YG, Chan FK, Sung JJ. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells Gut 2004 53(3):331-8 PubMed ID: 14960510 DOI: 10.1136/gut.2003.021105

18973 Nozawa Y, Nishihara K, Akizawa Y, Orimoto N, Nakano M, Uji T, Ajioka H, Kanda A, Matsuura N, Kiniwa M. Protein kinase C activation by Helicobacter pylori in human gastric epithelial cells limits interleukin-8 production through suppression of extracellular signal-regulated kinase J Pharmacol Sci 2004 94(3):233-9. PubMed ID: 15037807 DOI: 10.1254/jphs.94.233

18977 Nozawa Y, Nishihara K, Akizawa Y, Orimoto N, Nakano M, Uji T, Ajioka H, Kanda A, Matsuura N, Kiniwa M. Lafutidine inhibits Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells J Gastroenterol Hepatol 2004 19(5):506-11 PubMed ID: 15086593 DOI: 10.1111/j.1440-1746.2003.03330.x

19052 Ueda K, Iwahashi M, Matsuura I, Nakamori M, Nakamura M, Ojima T, Naka T, Ishida K, Matsumoto K, Nakamura T, Yamaue H. Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice Eur J Cancer 2004 40(14):2135-42 PubMed ID: 15341989 DOI: 10.1016/j.ejca.2004.05.006

19061 Mitsuko MASUTANI, Tadashige NOZAKI, Hiroki SASAKI, Tesshi YAMADA, Takashi KOHNO, Kimiko SHIMIZU, Masahiro GOTOH, Masahiko SHIRAISHI, Jun YOKOTA, Setsuo HIROHASHI, Hitoshi NAKAGAMA, Takashi SUGIMURA Poly(ADP-ribose) polymerase-1 gene in human tumor cell lines: Its expression and structural alteration Proceedings of the Japan Academy, Series B 2004 80:114-118 DOI: 10.2183/pjab.80.114

3865 Tominaga K, Higuchi K, Sasaki E, Suto R, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Kim S, Iwao H, Arakawa T. Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. Aliment Pharmacol Ther. 2004 20 Suppl 1:143-50 PubMed ID: 15298620 DOI: 10.1111/j.1365-2036.2004.01986.x

5922 Meng H, Lu C, Mabuchi H, Tanigawa N. Prognostic significance and different properties of survivin splicing variants in gastric cancer. Cancer Lett 2004 216(2):147-55 PubMed ID: 15533590 DOI: 10.1016/j.canlet.2003.12.020

5923 Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H. Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome. Pharmacol Res. 2004 50(1):65-76 PubMed ID: 15082031 DOI: 10.1016/j.phrs.2003.12.015

5924 Oyama K, Terashima M, Takagane A, Maesawa C. Prognostic significance of peritoneal minimal residual disease in gastric cancer detected by reverse transcription-polymerase chain reaction. Br J Surg 2004 91(4):435-43 PubMed ID: 15048743 DOI: 10.1002/bjs.4455

5925 Wong BC, Jiang XH, Lin MC, Tu SP, Cui JT, Jiang SH, Wong WM, Yuen MF, Lam SK, Kung HF. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Gastroenterology 2004 126(1):136-47 PubMed ID: 14699495 DOI: 10.1053/j.gastro.2003.10.063

5926 Jiang XH, Tu SP, Cui JT, Lin MC, Xia HH, Wong WM, Chan AO, Yuen MF, Jiang SH, Lam SK, Kung HF, Soh JW, Weinstein IB, Wong BC. Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis. Cancer Res 2004 64(16):5787-94 PubMed ID: 15313921 DOI: 10.1158/0008-5472.CAN-03-1172

5929 Chang YJ, Wu MS, Lin JT, Sheu BS, Muta T, Inoue H, Chen CC. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol 2004 66(6):1465-77 PubMed ID: 15456896 DOI: 10.1124/mol.104.005199

3103 Adachi, Keiko, Osaki, Mitsuhiko, Kase, Satoru, Takeda, Ami, Ito, Hisao Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines. Int J Oncol 2003 23:713-9 PubMed ID: 12888908

18645 Helicobacter pylori induces antiapoptosis through buclear factor-kappaB activation Helicobacter pylori induces antiapoptosis through buclear factor-kappaB activation J Infect Dis 2003 188(11):1741-51 PubMed ID: 14639546 DOI: 10.1086/379629

18915 Yu J, Leung WK, Lee TL, Tse PC, To KF, Sung JJ. Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma Int J Oncol 2003 22(5):1025-31 PubMed ID: 12684668

18964 Ebert MP, Yu J, Hoffmann J, Rocco A, Röcken C, Kahmann S, Müller O, Korc M, Sung JJ, Malfertheiner P. Loss of beta-catenin expression in metastatic gastric cancer J Clin Oncol 2003 21(9):1708-14 PubMed ID: 12721245 DOI: 10.1200/JCO.2003.10.017

3797 Wu J, Xia HH, Tu SP, Fan DM, Lin MC, Kung HF, Lam SK, Wong BC. 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. Carcinogenesis 2003 24(2):243-7 PubMed ID: 12584173 DOI: 10.1093/carcin/24.2.243

5930 Tu SP, Jiang XH, Lin MC, Cui JT, Yang Y, Lum CT, Zou B, Zhu YB, Jiang SH, Wong WM, Chan AO, Yuen MF, Lam SK, Kung HF, Wong BC. Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res 2003 63(22):7724-32 PubMed ID: 14633697

14329 Hata K, Hori K, Ogasawara H, Takahashi S. Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene Toxicol Lett 2003 143(1):1-7 PubMed ID: 12697374 DOI: 10.1016/s0378-4274(03)00092-4

17305 Jawhari AU, Buda A, Jenkins M, Shehzad K, Sarraf C, Noda M, Farthing MJ, Pignatelli M, Adams JC. Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro Am J Pathol 2003 162(1):69-80 PubMed ID: 12507891 DOI: 10.1016/S0002-9440(10)63799-6

18970 Leung WK, Yu J, Chan FK, To KF, Chan MW, Ebert MP, Ng EK, Chung SC, Malfertheiner P, Sung JJ. Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues J Pathol 2002 197(5):582-8 PubMed ID: 12210076 DOI: 10.1002/path.1147

5939 Okuyama T, Ishihara S, Sato H, Rumi MA, Kawashima K, Miyaoka Y, Suetsugu H, Kazumori H, Cava CF, Kadowaki Y, Fukuda R, Kinoshita Y. Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines. J Lab Clin Med 2002 140(2):92-102 PubMed ID: 12228765 DOI: 10.1067/mlc.2002.125784

5940 Chong JM, Sakuma K, Sudo M, Osawa T, Ohara E, Uozaki H, Shibahara J, Kuroiwa K, Tominaga S, Hippo Y, Aburatani H, Funata N, Fukayama M. Interleukin-1beta expression in human gastric carcinoma with Epstein-Barr virus infection. J Virol 2002 76(13):6825-31 PubMed ID: 12050395 DOI: 10.1128/jvi.76.13.6825-6831.2002

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