CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0995 : MDCK]

2581 Oberleithner H, Vogel U, Kersting U, Steigner W Madin-Darby canine kidney cells. II. Aldosterone stimulates Na+/H+ and Cl-/HCO3- exchange. Pflugers Arch 1990 416:533-9 PubMed ID: 2172916 DOI: 10.1007/bf00382686

260 Gaush CR, Hard WL, Smith TF. Characterization of an established line of canine kidney cells (MDCK) Proc Soc Exp Biol Med. 1966 122(3):931-5 PubMed ID: 5918973 DOI: 10.3181/00379727-122-31293

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21581 Watabe T, Yamahira S, Takakura K, Thumkeo D, Narumiya S, Matsuda M, Terai K. Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner. Elife 2024 12 PubMed ID: 38276879 DOI: 10.7554/eLife.86727

22089 Daidoji T, Sadakane H, Garan K, Kawashita N, Arai Y, Watanabe Y, Nakaya T. The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region. PLoS Pathog 2024 20(10):e1012427 PubMed ID: 39436936 DOI: 10.1371/journal.ppat.1012427

22132 Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, Tsukiji S, Otani T, Furuse M, Sorkin A, Matsuda M, Terai K. Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells. Cell Rep 2024 43(11):114986 PubMed ID: 39546398 DOI: 10.1016/j.celrep.2024.114986

18127 Yasuhiro Okada, Kenji Manabe, Kenichi Nagano, Maki Sakamoto, Atsuko Hayase, Takuya Mori, Risa Bandou, Hiroshi Ikegaya, Yoshito Itoh, Takaaki Nakaya, Ryohei Hirose Antipathogenic coating agents to improve the innate hand-barrier mechanism Environmental Technology & Innovation 2023 32:103249 DOI: 10.1016/j.eti.2023.103249

19642 Ryohei Hirose, Takehiro Yoshimatsu, Hajime Miyazaki, Katsuya Miura, Koji Fukazawa, Katsuma Yamauchi, Naoto Watanabe, Takuma Yoshida, Risa Bandou, Yoshito Itoh, Takaaki Nakaya Antiviral papers generated from copper-supported TEMPO-oxide cellulose: Antiviral surface objective performance evaluation and underlying mechanisms Journal of Environmental Chemical Engineering 2023 11:110592 DOI: 10.1016/j.jece.2023.110592

19860 Yamashita M, Tamamitsu M, Kirisako H, Goda Y, Chen X, Hattori K, Ota S. High-Throughput 3D Imaging Flow Cytometry of Suspended Adherent 3D Cell Cultures Small Methods 2023 e2301318 PubMed ID: 38133483 DOI: 10.1002/smtd.202301318

21178 Umehara Y, Aoyagi H. Development of a simple cultured cell-anaerobic microbial co-culture system using liquid paraffin. J Biosci Bioeng 2023 PubMed ID: 37069015 DOI: 10.1016/j.jbiosc.2023.03.008

21199 Sakakibara S, Abdellatef SA, Yamamoto S, Kamimura M, Nakanishi J. Photoactivatable surfaces resolve the impact of gravity vector on collective cell migratory characteristics. Sci Technol Adv Mater 2023 24(1):2206525 PubMed ID: 37151805 DOI: 10.1080/14686996.2023.2206525

21408 Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue-Sawano A, Miyawaki A, Matsuda M, Terai K. Knockout of all ErbB-family genes delineates their roles in proliferation, survival and migration. J Cell Sci 2023 136(16) PubMed ID: 37519219 DOI: 10.1242/jcs.261199

21435 Watabe T, Yamahira S, Matsuda M, Terai K. Visual quantification of prostaglandin E2 discharge from a single cell. Cell Struct Funct 2023 PubMed ID: 37813623 DOI: 10.1247/csf.23047

17620 Saito S, Funayama K, Kato W, Okuda M, Kawamoto M, Matsubara T, Sato T, Sato A, Otsuguro S, Sasaki M, Orba Y, Sawa H, Maenaka K, Shindo K, Imoto M, Arai MA. Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses J Nat Prod 2022 85(11):2583-2591 PubMed ID: 36223390 DOI: 10.1021/acs.jnatprod.2c00550

15686 Hosokawa-Muto J, Sassa-O'Brien Y, Fujinami Y, Nakahara H. Analysis Comparison for Rapid Identification of Pathogenic Virus from Infected Tissue Samples Diagnostics (Basel) 2022 12(1):196 PubMed ID: 35054363 DOI: 10.3390/diagnostics12010196

16141 Hatano H, Meng F, Sakata M, Matsumoto A, Ishihara K, Miyahara Y, Goda T. Transepithelial delivery of insulin conjugated with phospholipid-mimicking polymers via biomembrane fusion-mediated transcellular pathways Acta Biomater 2022 140:674-685 PubMed ID: 34896268 DOI: 10.1016/j.actbio.2021.12.003

16436 Hirose R, Miyazaki H, Bandou R, Watanabe N, Yoshida T, Daidoji T, Itoh Y, Nakaya T. Stability of SARS-CoV-2 and influenza virus varies across different paper types J Infect Chemother 2022 28(2):252-256 PubMed ID: 34799238 DOI: 10.1016/j.jiac.2021.11.006

16738 Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding BPB Reports 2022 5:66-69 DOI: 10.1248/bpbreports.5.3_66

20866 Matsuura R, Kawamura A, Matsumoto Y, Iida Y, Kanayama M, Kurokawa M, Aida Y. Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E. Microorganisms 2022 10(9) PubMed ID: 36144398 DOI: 10.3390/microorganisms10091796

12486 Hirose R, Ikegaya H, Naito Y, Watanabe N, Yoshida T, Bandou R, Daidoji T, Itoh Y, Nakaya T. Survival of SARS-CoV-2 and influenza virus on the human skin: Importance of hand hygiene in COVID-19 Clin Infect Dis 2021 73(11):e4329-e4335 PubMed ID: 33009907 DOI: 10.1093/cid/ciaa1517

20146 Chang AC, Uto K, Homma K, Nakanishi J. Viscoelastically tunable substrates elucidate the interface-relaxation-dependent adhesion and assembly behaviors of epithelial cells. Biomaterials 2021 274:120861 PubMed ID: 33991949 DOI: 10.1016/j.biomaterials.2021.120861

14235 Konishi Y, Ichise H, Watabe T, Oki C, Tsukiji S, Hamazaki Y, Murakawa Y, Takaori-Kondo A, Terai K, Matsuda M. Intravital imaging identifies the VEGF-TXA2 axis as a critical promoter of PGE2 secretion from tumor cells and immune evasion Cancer Res 2021 canres.4245.2020 PubMed ID: 34035084 DOI: 10.1158/0008-5472.CAN-20-4245

20156 Oyama TG, Oyama K, Kimura A, Yoshida F, Ishida R, Yamazaki M, Miyoshi H, Taguchi M. Collagen hydrogels with controllable combined cues of elasticity and topography to regulate cellular processes. Biomed Mater 2021 PubMed ID: 34030146 DOI: 10.1088/1748-605X/ac0452

15520 Tomoko Gowa Oyama, Kotaro Oyama, Hiromi Miyoshi, Mitsumasa Taguchi 3D cell sheets formed via cell-driven buckling-delamination of patterned thin films Materials & Design 2021 208:109975 DOI: 10.1016/j.matdes.2021.109975

20409 Nagahama M, Kobayashi K, Takehara M. Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin. Toxins (Basel) 2021 13(10) PubMed ID: 34679014 DOI: 10.3390/toxins13100721

20456 Hirose R, Itoh Y, Ikegaya H, Miyazaki H, Watanabe N, Yoshida T, Bandou R, Daidoji T, Nakaya T. Evaluation of the Residual Disinfection Effects of Commonly Used Skin Disinfectants against Viruses: An Innovative Contact Transmission Control Method. Environ Sci Technol 2021 55(23):16044-16055 PubMed ID: 34841856 DOI: 10.1021/acs.est.1c05296

16046 Yamamoto K, Miura H, Ishida M, Mii Y, Kinoshita N, Takada S, Ueno N, Sawai S, Kondo Y, Aoki K. Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis Nat Commun 2021 12(1):7145 PubMed ID: 34880255 DOI: 10.1038/s41467-021-27458-3

11826 Matsuo H, Nakanishi J, Noguchi Y, Kitagawa K, Shigemura K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T. Nanaomycin K, a new epithelial-mesenchymal transition inhibitor produced by the actinomycete "Streptomyces rosa subsp. notoensis" OS-3966. J. Biosci. Bioeng. 2020 129(3):291-295 PubMed ID: 31582334 DOI: 10.1016/j.jbiosc.2019.09.007

10499 Naoya Hino, Leone Rossetti, Ariadna Marín-Llauradó, Kazuhiro Aoki, Xavier Trepat, Michiyuki Matsuda, Tsuyoshi Hirashima ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization Dev Cell 2020 S1534-5807(20)30400-7 PubMed ID: 32497487 DOI: 10.1016/j.devcel.2020.05.011

11999 Daidoji T, Kajikawa J, Arai Y, Watanabe Y, Hirose R, Nakaya T. Infection of Human Tracheal Epithelial Cells by H5 Avian Influenza Virus Is Regulated by the Acid Stability of Hemagglutinin and the pH of Target Cell Endosomes. Viruses 2020 PubMed ID: 31936692 DOI: 10.3390/v12010082

12119 Suzuki S, Shichinohe S, Itoh Y, Nakayama M, Ishigaki H, Mori Y, Ogata-Nakahara A, Nguyen CT, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution. Antiviral Res. 2020 PubMed ID: 32272175 DOI: 10.1016/j.antiviral.2020.104790

13015 Nagahama M, Seike S, Ochi S, Kobayashi K, Takehara M. Clostridium perfringens Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca²⁺-Dependent Manner. Toxins (Basel) 2020 PubMed ID: 32365779 DOI: 10.3390/toxins12050286

13033 Ito H, Nishimura H, Kisu T, Hagiwara H, Watanabe O, Kadji FMN, Sato K, Omiya S, Takashita E, Nobusawa E. Low response in eliciting neuraminidase inhibition activity of sera among recipients of a split, monovalent pandemic influenza vaccine during the 2009 pandemic. PLoS One 2020 PubMed ID: 32401814 DOI: 10.1371/journal.pone.0233001

13084 Monden Y, Tsukamoto A, Ushida T, Kobayashi E, Nakagawa K, Sakuma I. An in vitro model of temporal enhancement of epithelium barrier permeability by low-energy shock waves without contrast agents. Med Biol Eng Comput 2020 PubMed ID: 32591989 DOI: 10.1007/s11517-020-02207-8

13398 Kajiwara N, Nomura N, Ukaji M, Yamamoto N, Kohara M, Yasui F, Sakoda Y, Kida H, Shibasaki F. Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus. Sci Rep 2020 PubMed ID: 33093460 DOI: 10.1038/s41598-020-74604-w

13560 Pezzotti G, Zhu W, Adachi T, Horiguchi S, Marin E, Boschetto F, Ogitani E, Mazda O. Metabolic machinery encrypted in the Raman spectrum of influenza A virus-inoculated mammalian cells J Cell Physiol 2020 235(6):5146-5170 PubMed ID: 31710091 DOI: 10.1002/jcp.29392

14807 Ishida-Ishihara S, Akiyama M, Furusawa K, Naguro I, Ryuno H, Sushida T, Ishihara S, Haga H. Osmotic gradients induce stable dome morphogenesis on extracellular matrix J Cell Sci 2020 133(14):jcs243865 PubMed ID: 32576662 DOI: 10.1242/jcs.243865

16815 Watabe T, Terai K, Sumiyama K, Matsuda M. Booster, a Red-Shifted Genetically Encoded Förster Resonance Energy Transfer (FRET) Biosensor Compatible with Cyan Fluorescent Protein/Yellow Fluorescent Protein-Based FRET Biosensors and Blue Light-Responsive Optogenetic Tools ACS Sens 2020 5(3):719-730 PubMed ID: 32101394 DOI: 10.1021/acssensors.9b01941

11278 Nakanishi J, Sugiyama K, Matsuo H, Takahashi Y, Omura S, Nakashima T. An Application of Photoactivatable Substrate for the Evaluation of Epithelial-mesenchymal Transition Inhibitors. Anal Sci 2019 PubMed ID: 30393243 DOI: 10.2116/analsci.18SDP07

11315 Arai Y, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y. Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals. J. Virol. 2019 PubMed ID: 30463961 DOI: 10.1128/JVI.01969-18

11362 Hatano H, Goda T, Matsumoto A, Miyahara Y. Induced Proton Perturbation for Sensitive and Selective Detection of Tight Junction Breakdown. Anal. Chem. 2019 PubMed ID: 30596415 DOI: 10.1021/acs.analchem.8b05237

5331 Kinjo T, Terai K, Horita S, Nomura N, Sumiyama K, Togashi K, Iwata S, Matsuda M. FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics. Nat Methods 2019 16(10):1029-1036 PubMed ID: 31501546 DOI: 10.1038/s41592-019-0541-5

5436 Hirose R, Nakaya T, Naito Y, Daidoji T, Bandou R, Inoue K, Dohi O, Yoshida N, Konishi H, Itoh Y. Situations Leading to Reduced Effectiveness of Current Hand Hygiene against Infectious Mucus from Influenza Virus-Infected Patients. mSphere 2019 4(5) PubMed ID: 31533996 DOI: 10.1128/mSphere.00474-19

11621 Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y. PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals. PLoS Pathog. 2019 PubMed ID: 31265471 DOI: 10.1371/journal.ppat.1007919

11918 Hatano H, Goda T, Matsumoto A, Miyahara Y. Induced Proton Dynamics on Semiconductor Surfaces for Sensing Tight Junction Formation Enhanced by an Extracellular Matrix and Drug. ACS Sens 2019 PubMed ID: 31763825 DOI: 10.1021/acssensors.9b01635

12518 Fujii Y, Ochi Y, Tuchiya M, Kajita M, Fujita Y, Ishimoto Y, Okajima T. Spontaneous Spatial Correlation of Elastic Modulus in Jammed Epithelial Monolayers Observed by AFM Biophys J 2019 116(6):1152-1158 PubMed ID: 30826009 DOI: 10.1016/j.bpj.2019.01.037

12978 Kojima C, Narita Y, Nakajima Y, Morimoto N, Yoshikawa T, Takahashi N, Handa A, Waku T, Tanaka N. Modulation of Cell Adhesion and Differentiation on Collagen Gels by the Addition of the Ovalbumin Secretory Signal Peptide. ACS Biomater Sci Eng 2019 PubMed ID: 33405701 DOI: 10.1021/acsbiomaterials.8b01505

10717 Zhou Y, Saito M, Miyamoto T, Novak P, Shevchuk AI, Korchev YE, Fukuma T, Takahashi Y. Nanoscale Imaging of Primary Cilia with Scanning Ion Conductance Microscopy. Anal. Chem. 2018 90:2891-2895 PubMed ID: 29345134 DOI: 10.1021/acs.analchem.7b05112

10801 Abdellatef SA, Nakanishi J. Photoactivatable substrates for systematic study of the impact of an extracellular matrix ligand on appearance of leader cells in collective cell migration. Biomaterials 2018 169:72-84 PubMed ID: 29655082 DOI: 10.1016/j.biomaterials.2018.03.045

11055 Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K. Automated Adherent Cell Elimination by a High-Speed Laser Mediated by a LightResponsive Polymer Commun Biol 2018 1:218 PubMed ID: 30534610 DOI: 10.1038/s42003-018-0222-4

11225 Miyamoto R, Kurita S, Tani H, Ikeda T, Ishizaka M, Saima H, Kobayashi M, Tamura K, Bonkobara M. Canine squamous cell carcinoma cell lines with high expression of survivin are sensitive to survivin inhibitor YM155. Vet. J. 2018 PubMed ID: 30268330 DOI: 10.1016/j.tvjl.2018.09.001

11494 Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N. Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport. J. Cell Biol. 2018 217(12):4164-4183 PubMed ID: 30297389 DOI: 10.1083/jcb.201711178

11238 Nagahama M, Takehara M, Kobayashi K. Interaction of Clostridium perfringens Iota Toxin and Lipolysis-Stimulated Lipoprotein Receptor (LSR). Toxins (Basel) 2018 PubMed ID: 30297616 DOI: 10.3390/toxins10100405

4121 Kumeta M, Panina Y, Yamazaki H, Takeyasu K, Yoshimura SH. N-terminal dual lipidation-coupled molecular targeting into the primary cilium. Genes Cells 2018 PubMed ID: 29900630 DOI: 10.1111/gtc.12603

4289 Nagahama M, Takehara M, Miyamoto K, Ishidoh K, Kobayashi K. Acid Sphingomyelinase Promotes Cellular Internalization of Clostridium perfringens Iota-Toxin. Toxins (Basel) 2018 PubMed ID: 29783772 DOI: 10.3390/toxins10050209

4290 Imanishi A, Murata T, Sato M, Hotta K, Imayoshi I, Matsuda M, Terai K. A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level. Cell Struct. Funct. 2018 PubMed ID: 29962383 DOI: 10.1247/csf.18013

4465 Watanabe Y, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T. Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells. J. Virol. 2018 92(11) PubMed ID: 29563293 DOI: 10.1128/JVI.02004-17

5776 Sumaru K, Takagi T, Morishita K, Kanamori T. Photoresponsive Aqueous Dissolution of Poly( N-Isopropylacrylamide) Functionalized with o-Nitrobenzaldehyde through Phase Transition. Biomacromolecules 2018 19(7):2913-2922 PubMed ID: 29641886 DOI: 10.1021/acs.biomac.8b00470

10515 Hirashima T, Hoshuyama M, Adachi T. In vitro tubulogenesis of Madin-Darby canine kidney (MDCK) spheroids occurs depending on constituent cell number and scaffold gel concentration. J. Theor. Biol. 2017 435:110-115 PubMed ID: 28923372 DOI: 10.1016/j.jtbi.2017.09.009

10604 Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh RE, Matsuda M. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev. Cell 2017 43:305-317.e5 PubMed ID: 29112851 DOI: 10.1016/j.devcel.2017.10.016

11030 Xu X, Yoshizaki H, Ishigaki Y, Kubo E, Minato H, Kiyokawa E. Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells Mol Vis 2017 23:1081-1092 PubMed ID: 29872253

9124 Masahiro Nagahama, Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi Cellular Uptake of Clostridium Botulinum C2 Toxin Requires Acid Sphingomyelinase Activity Infect Immun 2017 85 (4) PubMed ID: 28138018 DOI: 10.1128/IAI.00966-16

14258 Hirose R, Nakaya T, Naito Y, Daidoji T, Watanabe Y, Yasuda H, Konishi H, Itoh Y. Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus Sci Rep 2017 7(1):13186 PubMed ID: 29030631 DOI: 10.1038/s41598-017-13732-2

14767 Elgendy EM, Arai Y, Kawashita N, Daidoji T, Takagi T, Ibrahim MS, Nakaya T, Watanabe Y. Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons J Gen Virol 2017 98(1):6-17 PubMed ID: 27926816 DOI: 10.1099/jgv.0.000674

7058 Ueyama T, Ninoyu Y, Nishio SY, Miyoshi T, Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D, Sakaguchi H, Watanabe N, Usami SI, Saito N, Kitajiri SI. Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss. EMBO Mol Med 2016 8:1310-1324 PubMed ID: 27707755 DOI: 10.15252/emmm.201606609

7126 Fukao M, Kondo E, Nishino H, Hattori R, Horie A, Hashimoto Y. Presence of an H(+)/Quinidine Antiport System in Madin-Darby Canine Kidney Cells. Eur J Drug Metab Pharmacokinet 2016 41:819-824 PubMed ID: 26628429 DOI: 10.1007/s13318-015-0314-1

9986 Kawabata N, Matsuda M. Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. PLoS ONE 2016 11:e0167940 PubMed ID: 27936234 DOI: 10.1371/journal.pone.0167940

19247 Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y. Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses PLoS Pathog 2016 12(4):e1005583 PubMed ID: 27097026 DOI: 10.1371/journal.ppat.1005583

10863 Kazuya Furusawa, Takeomi Mizutani, Naoki Sasaki Development of the evaluation system for barrier functions of engineered epithelial lumens Regen Ther 2016 3:82-89 PubMed ID: 31245477 DOI: 10.1016/j.reth.2016.02.010

5336 Yoshizaki H, Ogiso H, Okazaki T, Kiyokawa E. Comparative lipid analysis in the normal and cancerous organoids of MDCK cells. J Biochem 2016 159(6):573-84 PubMed ID: 26783265 DOI: 10.1093/jb/mvw001

5339 Marlar S, Abdellatef SA, Nakanishi J. Reduced adhesive ligand density in engineered extracellular matrices induces an epithelial-mesenchymal-like transition. Acta Biomater 2016 39:106-113 PubMed ID: 27163400 DOI: 10.1016/j.actbio.2016.05.006

9117 Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis PLoS One 2016 11 (1), e0147957 PubMed ID: 26807591 DOI: 10.1371/journal.pone.0147957

10144 Teruhisa Takagishi, Masataka Oda, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama Oligomer Formation of Clostridium Perfringens Epsilon-Toxin Is Induced by Activation of Neutral Sphingomyelinase Biochim Biophys Acta 2016 1858(11):2681-2688 PubMed ID: 27453200 DOI: 10.1016/j.bbamem.2016.07.009

12209 R Hirose, T Daidoji, Y Naito, Y Watanabe, Y Arai 5, T Oda, H Konishi, M Yamawaki, Y Itoh, T Nakaya Long-term detection of seasonal influenza RNA in faeces and intestine Clin Microbiol Infect 2016 22(9):813.e1-813.e7 PubMed ID: 27424942 DOI: 10.1016/j.cmi.2016.06.015

14462 Ryosuke Takahashi and Takaharu Okajima Comparison between power-law rheological parameters of living cells in frequency and time domains measured by atomic force microscopy Japanese Journal of Applied Physics 2016 55 DOI: 10.7567/JJAP.55.08NB22

17108 Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M. OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia EMBO Mol Med 2016 8(4):422-36 PubMed ID: 26976612 DOI: 10.15252/emmm.201506154

7165 Yoshizaki H, Kuwajima Y, Minato H, Kiyokawa E. Regulation of Ripply1 expression in MDCK organoids. Biochem. Biophys. Res. Commun. 2015 468:337-42 PubMed ID: 26514726 DOI: 10.1016/j.bbrc.2015.10.099

7286 Hosokawa-Muto J, Fujinami Y, Mizuno N. Evaluation of the Universal Viral Transport system for long-term storage of virus specimens for microbial forensics. J Forensic Leg Med 2015 34:29-33 PubMed ID: 26165655 DOI: 10.1016/j.jflm.2015.04.019

7485 Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T. Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH. J. Biol. Chem. 2015 290:10627-42 PubMed ID: 25673693 DOI: 10.1074/jbc.M114.611327

7534 K Furusawa, T Mizutani, H Machino, S Yahata, A Fukui, N Sasaki Application of multichannel collagen gels in construction of epithelial lumen-like engineered tissues. ACS Biomater Sci Eng 2015 1:539-548 PubMed ID: 33434970 DOI: 10.1021/acsbiomaterials.5b00003

9116 Masahiro Nagahama, Akiko Ohkubo, Yoshihito Kinouchi, Keiko Kobayashi, Kazuaki Miyamoto, Masaya Takehara, Jun Sakurai Clostridium Perfringens TpeL Induces Formation of Stress Fibers via Activation of RhoA-ROCK Signaling Pathway Biol Pharm Bull 2015 38 (5), 732-9 PubMed ID: 25947919 DOI: 10.1248/bpb.b14-00842

14957 Yamaguchi N, Mizutani T, Kawabata K, Haga H. Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin β1 and PI3K Sci Rep 2015 5:7656 PubMed ID: 25563751 DOI: 10.1038/srep07656

14992 Imai M, Furusawa K, Mizutani T, Kawabata K, Haga H. Three-dimensional morphogenesis of MDCK cells induced by cellular contractile forces on a viscous substrate Sci Rep 2015 5:14208 PubMed ID: 26374384 DOI: 10.1038/srep14208

9107 Masahiro Nagahama, Chihiro Takahashi, Kouhei Aoyanagi, Ryo Tashiro, Keiko Kobayashi, Yoshihiko Sakaguchi, Kazumi Ishidoh, Jun Sakurai Intracellular Trafficking of Clostridium Botulinum C2 Toxin Toxicon 2014 82, 76-82 PubMed ID: 24582943 DOI: 10.1016/j.toxicon.2014.02.009

10262 Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D FEMS Microbiol Lett 2014 2014 Aug;357(2):115-22 PubMed ID: 25041523 DOI: 10.1111/1574-6968.12527

5338 Sogawa N, Hirai K, Sogawa C, Ohyama K, Miyazaki I, Tsukamoto G, Asanuma M, Sasaki A, Kitayama S. Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression. Life Sci 2013 92(12):727-32 PubMed ID: 23399700 DOI: 10.1016/j.lfs.2013.01.031

5340 Mori Y, Yagi S, Sakurai A, Matsuda M, Kiyokawa E. Insufficient ability of Rac1b to perturb cystogenesis. Small GTPases 2013 4(1):9-15 PubMed ID: 23411476 DOI: 10.4161/sgtp.23311

14193 Yu YC, Sohma Y, Takimoto S, Miyauchi T, Yasui M. Direct visualization and quantitative analysis of water diffusion in complex biological tissues using CARS microscopy Sci Rep 2013 3:2745 PubMed ID: 24067894 DOI: 10.1038/srep02745

17164 Hamamoto I, Takaku H, Tashiro M, Yamamoto N. High yield production of influenza virus in Madin Darby canine kidney (MDCK) cells with stable knockdown of IRF7 PLoS One 2013 8(3):e59892 PubMed ID: 23555825 DOI: 10.1371/journal.pone.0059892

7635 Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T. MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J. 2012 31:481-93 PubMed ID: 22085929 DOI: 10.1038/emboj.2011.416

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5335 Yagi S, Matsuda M, Kiyokawa E. Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure. PLoS One 2012 7(12):e52258 PubMed ID: 23284959 DOI: 10.1371/journal.pone.0052258

5343 Komura K, Ise H, Akaike T. Dynamic behaviors of vimentin induced by interaction with GlcNAc molecules. Glycobiology 2012 22(12):1741-59 PubMed ID: 22846177 DOI: 10.1093/glycob/cws118

9090 Masahiro Nagahama, Mariko Umezaki, Ryo Tashiro, Masataka Oda, Keiko Kobayashi, Masahiro Shibutani, Teruhisa Takagishi, Kazumi Ishidoh, Mitsunori Fukuda, Jun Sakurai Intracellular Trafficking of Clostridium Perfringens Iota-Toxin B Infect Immun 2012 80 (10), 3410-6 PubMed ID: 22825447 DOI: 10.1128/IAI.00483-12

7743 Nagahama M, Itohayashi Y, Hara H, Higashihara M, Fukatani Y, Takagishi T, Oda M, Kobayashi K, Nakagawa I, Sakurai J. Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. FEBS J. 2011 278:3395-407 PubMed ID: 21781280 DOI: 10.1111/j.1742-4658.2011.08263.x

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8048 Kobayashi N, Saito T, Uematsu T, Kishi K, Toba M, Kohda N, Suzuki T. Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice. Int. Immunopharmacol. 2011 11:199-203 PubMed ID: 21095259 DOI: 10.1016/j.intimp.2010.11.019

9083 Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis Infect Immun 2011 79 (11), 4353-60 PubMed ID: 21911469 DOI: 10.1128/IAI.05677-11

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15672 Yamasaki T, Kawamura K, Hatori A, Yui J, Yanamoto K, Yoshida Y, Ogawa M, Nengaki N, Wakisaka H, Fukumura T, Zhang MR. PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein Nucl Med Commun 2010 31(11):985-93 PubMed ID: 20859232 DOI: 10.1097/MNM.0b013e32833fbf87

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15692 Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura-Takagi Y, Morita N, Sato Y, Saruta C, Nishibe H, Sadakata T, Shinoda Y, Hayashi K, Mishima Y, Baba H, Furuichi T. Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia PLoS One 2010 5(11):e13932 PubMed ID: 21085684 DOI: 10.1371/journal.pone.0013932

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8503 Nagahama M, Hagiyama T, Kojima T, Aoyanagi K, Takahashi C, Oda M, Sakaguchi Y, Oguma K, Sakurai J. Binding and internalization of Clostridium botulinum C2 toxin. Infect. Immun. 2009 77:5139-48 PubMed ID: 19720757 DOI: 10.1128/IAI.00638-09

8710 Sugibayashi K, Onuki Y, Takayama K. Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate. Eur J Pharm Sci 2009 36:246-53 PubMed ID: 19013238 DOI: 10.1016/j.ejps.2008.09.011

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18377 Yoshida S, Higuchi M, Shoji T, Yoshita M, Ishioka K, Takahashi M, Oie M, Tanaka Y, Uchiyama M, Fujii M. Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1 Virus Genes 2008 37(1):9-15 PubMed ID: 18461433 DOI: 10.1007/s11262-008-0234-0

8721 Emoto Y. Cellular aggregation facilitates anoikis in MDCK cells. J Physiol Sci 2008 58:371-80 PubMed ID: 18842164 DOI: 10.2170/physiolsci.RP011108

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9067 Keiko Kobayashi, Masahiro Nagahama, Noriko Ohkubo, Takashi Kojima, Hidenori Shirai, Shinobu Iwamoto, Masataka Oda, Jun Sakurai Role of Ca2+-binding Motif in Cytotoxicity Induced by Clostridium Perfringens Iota-Toxin Microb Pathog 2008 44 (4), 265-70 PubMed ID: 18060735 DOI: 10.1016/j.micpath.2007.10.010

9068 Yasuhiro Yamasaki, Daisuke Katsuo, Seiichiro Nakayasu, Cristina Salati, JingJing Duan, Yanan Zou, Yukihiko Matsuyama, Kenichi Yamaguchi, Tatsuya Oda Purification and Characterization of a Novel High Molecular Weight Exotoxin Produced by Red Tide Phytoplankton, Alexandrium Tamarense J Biochem Mol Toxicol 2008 22 (6), 405-15 PubMed ID: 19111002 DOI: 10.1002/jbt.20253

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9038 Masahiro Nagahama, Shinya Hayashi, Shinsuke Morimitsu, Jun Sakurai Biological Activities and Pore Formation of Clostridium Perfringens Beta Toxin in HL 60 Cells J Biol Chem 2003 278 (38), 36934-41 PubMed ID: 12851396 DOI: 10.1074/jbc.M306562200

15543 Kazuya HAYASHI, Motoyuki MORI, Yoko MATSUTANI KNOX, Tatuo SUZUTAN, Masahiro OGASAWARA, Itsuro YOSHIDA, Keizo HOSOKAWA, Akio TSUKUI, Masanobu AZUMA Anti Influenza Virus Activity of a Red-Fleshed Potato Anthocyanin Food Science and Technology Research 2003 9:242-244 DOI: 10.3136/fstr.9.242

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