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細胞番号 : 細胞名
RCB0993 : IEC 6  update : 2023/06/30
細胞特性(Comment:英)Rat small intestine epithelial cells. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 88071401 prior to order.
細胞特性(日)ラット小腸上皮細胞株。コラーゲン産生能があるとされているが未確認。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECACC 88071401 を必ずご参照ください。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA88071401 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 基礎的研究につきましては、使用制限はありません。しかし、使用条件等がECACCによって随時変更となる可能性があるので、購入前に、ECA88071401 を必ず参照すること。2) 商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 1994
動物種 _rat < Mammals
属名 Rattus
種名 norvegicus
採取組織 small intestine
細胞分類 normal
入手歴 overseas, ECACC
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0343
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 5% FBS + 4μg/ml Insulin
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
動物種PCR OK
アイソザイム検査 LD, NP
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 1件
Reference(日) 0件
利用者成果(英) 61件
利用者成果(日) 0件

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Reference(英)
1831  Quaroni A, Wands J, Trelstad, R L, Isselbacher, K J  Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria.  J Cell Biol  1979  80:248-65  PubMed ID: 88453   DOI: 10.1083/jcb.80.2.248

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19858  Mohamad Ishak NS, Kikuchi M, Ikemoto K.  Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells  Front Aging  2024  5:1351860  PubMed ID: 38487591   DOI: 10.3389/fragi.2024.1351860
17775  Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima  The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells  J. Excipients and Food Chem  2023  14:22-32   
19613  Sadia Afrin Rimi, Jaroslav Kristof, Md Jahangir Alam, Kyohei Oishi, Takumi Okada, Abubakar Hamza Sadiq, Kazuo Shimizu  Changes in Membrane Lipid Order of Cells by Optimized Microplasma Irradiation for High-Molecule Drug Absorption  Plasma Medicine  2023  13:15-32    DOI: 10.1615/plasmamed.2023050304
20460  Akao Y, Kuranaga Y, Heishima K, Sugito N, Morikawa K, Ito Y, Soga T, Ito T.  Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I.  J Nutr Biochem  2022  108922  PubMed ID: 34856354   DOI: 10.1016/j.jnutbio.2021.108922
16737  Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima  Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells  Scholars Academic Journal of Pharmacy  2022  11:60-66    DOI: 10.36347/sajp.2022.v11i04.002
20951  Huang IH, Miyashita SI, Hata T, Karatsu S, Hosoya K, Sagane Y.  Complete subunit structure of serotype C and D botulinum progenitor toxin complex induces vacuolation in the specific epithelial cell line.  Biochem Biophys Res Commun  2022  632:55-61  PubMed ID: 36201881   DOI: 10.1016/j.bbrc.2022.09.093
21150  Hosoya K, Miyashita SI, Karatsu S, Huang IH, Sagane Y.  Species-specific gene duplication in Clostridia produces variations of cholesterol-dependent cytolysin with different cytotoxicity.  Biochem Biophys Res Commun  2022  637:240-246  PubMed ID: 36410272   DOI: 10.1016/j.bbrc.2022.11.043
17777  Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima  The influence of 4-methylimidazole on the gastrointestinal epithelial cells  J. Excipients and Food Chem  2021  12:4-15   
20151  Guo M, Xu W, Yamamoto Y, Suzuki T.  Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells.  Arch Biochem Biophys  2021  707:108938  PubMed ID: 34051214   DOI: 10.1016/j.abb.2021.108938
20343  Xu W, Watanabe K, Mizukami Y, Yamamoto Y, Suzuki T.  Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest.  Arch Biochem Biophys  2021  109044  PubMed ID: 34597656   DOI: 10.1016/j.abb.2021.109044
16834  Ito Y, Taniguchi K, Kuranaga Y, Eid N, Inomata Y, Lee SW, Uchiyama K.  Uptake of MicroRNAs from Exosome-Like Nanovesicles of Edible Plant Juice by Rat Enterocytes  Int J Mol Sci  2021  22(7):3749  PubMed ID: 33916868   DOI: 10.3390/ijms22073749
11431  Matsui T, Ichikawa H, Fujita T, Takemura S, Takagi T, Osada-Oka M, Minamiyama Y.  Histidine and arginine modulate intestinal cell restitution via transforming growth factor-β1.  Eur. J. Pharmacol.  2019    PubMed ID: 30753862   DOI: 10.1016/j.ejphar.2019.02.006
9160  Minori Kubota, Kazuki Kakimoto, Takatoshi Nakagawa, Eiko Koubayashi, Kei Nakazawa, Hideki Tawa, Yuki Hirata, Toshihiko Okada, Ken Kawakami, Akira Asai, Shuhei Hosomi, Toshihisa Takeuchi, Shinya Fukunishi, Takuya Inoue, Michio Asahi, Kazuhide Higuchi  Autophagy Deficiency Exacerbates Colitis Through Excessive Oxidative Stress and MAPK Signaling Pathway Activation  PLoS One  2019  14 (11), e0225066  PubMed ID: 31703091   DOI: 10.1371/journal.pone.0225066
12474  Makino Y, Munakata S, Ueyama T, Honjo K, Kawano S, Takahashi M, Kojima Y, Tomiki Y, Sakamoto K.  Effects of Receptor for Advanced Glycation End-Products (RAGE) Signaling on Intestinal Ischemic Damage in Mice  Eur Surg Res  2019  60(5-6):239-247  PubMed ID: 31914449   DOI: 10.1159/000504751
10726  Mashima H, Watanabe N, Sekine M, Matsumoto S, Asano T, Yuhashi K, Sagihara N, Urayoshi S, Uehara T, Fujiwara J, Ishii T, Tsuboi R, Miyatani H, Ohnishi H.  The role of Gαq/Gα11 signaling in intestinal epithelial cells.  Biochem Biophys Rep  2018  13:93-98  PubMed ID: 29387814   DOI: 10.1016/j.bbrep.2018.01.003
10825  Islam MS, Kaji N, Mikawa S, Yang Q, Kusabe M, Hori M, Ozaki H.  Induction of myosin light chain kinase and CPI-17 by TGF-β accelerates contractile activity in intestinal epithelial cells.  J. Vet. Med. Sci.  2018  80(6):977-984  PubMed ID: 29695674   DOI: 10.1292/jvms.17-0684
12475  Kawano M, Miura T, Fujita M, Koike S, Imadome K, Ishikawa A, Yasuda T, Imamura T, Imai T, Nakayama F.  The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma  Clin Transl Radiat Oncol  2018  14:8-16  PubMed ID: 30406211   DOI: 10.1016/j.ctro.2018.10.004
9907  Kojo Y, Matsunaga S, Suzuki H, Sato H, Seto Y, Onoue S.  Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach.  Eur J Pharm Sci  2017  97:55-61  PubMed ID: 27810562   DOI: 10.1016/j.ejps.2016.10.032
10382  Tsukahara T, Hamouda N, Utsumi D, Matsumoto K, Amagase K, Kato S.  G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells.  Pharmacol. Res.  2017  123:27-39  PubMed ID: 28648739   DOI: 10.1016/j.phrs.2017.06.009
10414  Kamao M, Hirota Y, Suhara Y, Tsugawa N, Nakagawa K, Okano T, Hasegawa H.  Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring.  Anal Sci  2017  33:863-867  PubMed ID: 28690267   DOI: 10.2116/analsci.33.863
3919  Tatsunobu Matsui, Hiroshi Ichikawa, Tomoka Fujita, Tomohisa Takagi, Mayuko Osada-Oka, Yukiko Minamiyama  Histidine deficiency attenuates cell viability in rat intestinal epithelial cells by apoptosis via mitochondrial dysfunction  Journal of Nutrition & Intermediary Metabolism  2017  8:21-28    DOI: 10.1016/j.jnim.2017.05.002
9781  Miyashita S, Sagane Y, Suzuki T, Matsumoto T, Niwa K, Watanabe T.  Non-Toxic Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity.  Sci Rep  2016  6:31043  PubMed ID: 27507612   DOI: 10.1038/srep31043
10931    Interleukin-33, an interleukin-1 like cytokine accelerates cell migration in IEC-6 cells  Asian Journal of Medical and Biological Research  2016  2    DOI: 10.3329/ajmbr.v2i4.30999
12692  Narita T, Naganuma T, Sase Y, Kihara A.  Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases  Sci Rep  2016  6:25469  PubMed ID: 27136724   DOI: 10.1038/srep25469
13969  Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.  Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells  Br J Pharmacol  2016  173(16):2532-42  PubMed ID: 27300306   DOI: 10.1111/bph.13535
7156  Yokoe S, Nakagawa T, Kojima Y, Higuchi K, Asahi M.  Indomethacin-induced intestinal epithelial cell damage is mediated by pVHL activation through the degradation of collagen I and HIF-1α.  Biochem. Biophys. Res. Commun.  2015  468:671-6  PubMed ID: 26551465   DOI: 10.1016/j.bbrc.2015.11.014
9147  Satoshi Harada, Takatoshi Nakagawa, Shunichi Yokoe, Shoko Edogawa, Toshihisa Takeuchi, Takuya Inoue, Kazuhide Higuchi, Michio Asahi  Autophagy Deficiency Diminishes Indomethacin-Induced Intestinal Epithelial Cell Damage Through Activation of the ERK/Nrf2/HO-1 Pathway  J Pharmacol Exp Ther  2015  355 (3), 353-61  PubMed ID: 26404472   DOI: 10.1124/jpet.115.226431
9191  Ken Narabayashi, Yuko Ito, Nabil Eid, Kentaro Maemura, Takuya Inoue, Toshihisa Takeuchi, Yoshinori Otsuki, Kazuhide Higuchi  Indomethacin Suppresses LAMP-2 Expression and Induces Lipophagy and Lipoapoptosis in Rat Enterocytes via the ER Stress Pathway  J Gastroenterol   2015  50 (5), 541-54  PubMed ID: 25212253   DOI: 10.1007/s00535-014-0995-2
15199  Miyata K, Suzuki T, Hayashi S, Miyashita S, Ohyama T, Niwa K, Watanabe T, Sagane Y.  Hemagglutinin gene shuffling among Clostridium botulinum serotypes C and D yields distinct sugar recognition of the botulinum toxin complex  Pathog Dis  2015  73(7):ftv05  PubMed ID: 26223883   DOI: 10.1093/femspd/ftv054
16235  Saito R, Tamura M, Matsui H, Nagano Y, Suzuki H, Kaneko T, Mizokami Y, Hyodo I.  Qing Dai attenuates nonsteroidal anti-inflammatory drug-induced mitochondrial reactive oxygen species in gastrointestinal epithelial cells  J Clin Biochem Nutr  2015  56(1):8-14  PubMed ID: 25678747   DOI: 10.3164/jcbn.14-59
10262  Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane  Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D  FEMS Microbiol Lett  2014  2014 Aug;357(2):115-22  PubMed ID: 25041523   DOI: 10.1111/1574-6968.12527
15923  Yamawaki H, Mihara H, Suzuki N, Nishizono H, Uchida K, Watanabe S, Tominaga M, Sugiyama T.  Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage  Am J Physiol Gastrointest Liver Physiol  2014  307(1):G33-40  PubMed ID: 24789205   DOI: 10.1152/ajpgi.00105.2013
19008  Yamada Y, Mashima H, Sakai T, Matsuhashi T, Jin M, Ohnishi H.  Functional roles of TGF-β1 in intestinal epithelial cells through Smad-dependent and non-Smad pathways  Dig Dis Sci  2013  58(5):1207-17  PubMed ID: 23306843   DOI: 10.1007/s10620-012-2515-7
12707  Sekiya M, Kiyohara H, Maruyama H, Yabe T, Yamada H.  Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients  J Nat Med  2013  67(3):626-35  PubMed ID: 23203627   DOI: 10.1007/s11418-012-0724-1
12728  Miyashita S, Sagane Y, Inui K, Hayashi S, Miyata K, Suzuki T, Ohyama T, Watanabe T, Niwa K.  Botulinum toxin complex increases paracellular permeability in intestinal epithelial cells via activation of p38 mitogen-activated protein kinase  J Vet Med Sci   2013  75(12):1637-42  PubMed ID: 23884081   DOI: 10.1292/jvms.13-0164
12709  Miyashita S, Sagane Y, Niwa K, Watanabe T.  Transport of the botulinum neurotoxin-associating protein, nontoxic nonhemagglutinin, across the rat small intestinal epithelial cell monolayer  FEMS Microbiol Lett  2013  346(1):73-80  PubMed ID: 23809018   DOI: 10.1111/1574-6968.12205
16297  Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T.  Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats  J Biol Chem  2013  288(46):33071-80  PubMed ID: 24085302   DOI: 10.1074/jbc.M113.477356
7726  Tamaki K, Otaka M, Shibuya T, Sakamoto N, Yamamoto S, Odashima M, Itoh H, Watanabe S.  Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer.  Evid Based Complement Alternat Med  2012  2012:278958  PubMed ID: 21822440   DOI: 10.1155/2012/278958
3894  Nagano Y1, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo HP, Majima HJ, Hyodo I.  Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells.  J Physiol Pharmacol  2012  63(2):137-42  PubMed ID: 22653900  
3909  Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I.  Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation.  J Clin Biochem Nutr  2012  51(3):196-203  PubMed ID: 23170047   DOI: 10.3164/jcbn.12-41
17936  Nakayama F, Yasuda T, Umeda S, Asada M, Imamura T, Meineke V, Akashi M.  Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12  J Biol Chem  2011  286(29):25823-34  PubMed ID: 21518765   DOI: 10.1074/jbc.M110.198267
7796  Matsuo T, Miyata K, Inui K, Ito H, Horiuchi R, Suzuki T, Yoneyama T, Oguma K, Niwa K, Watanabe T, Ohyama T.  Characterization of sugar recognition by the toxin complex produced by the Clostridium botulinum serotype C variant strain Yoichi.  FEMS Immunol. Med. Microbiol.  2011  63:35-43  PubMed ID: 21635567   DOI: 10.1111/j.1574-695X.2011.00825.x
7890  Ishihara H, Tanaka I, Yakumaru H, Tanaka M, Satoh A, Ishiwata A, Yokochi K, Kurematsu A, Ueda J, Shibata T, Hachiya M, Akashi M.  Acceleration of regeneration of mucosa in small intestine damaged by ionizing radiation using anabolic steroids.  Radiat. Res.  2011  175:367-74  PubMed ID: 21388280   DOI: 10.1667/RR2154.1
7981  Tamaki K, Otaka M, Takada M, Yamamoto S, Odashima M, Itoh H, Watanabe S.  Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cells.  Dig. Dis. Sci.  2011  56:1954-61  PubMed ID: 21253835   DOI: 10.1007/s10620-010-1558-x
7998  Ito H, Sagane Y, Miyata K, Inui K, Matsuo T, Horiuchi R, Ikeda T, Suzuki T, Hasegawa K, Kouguchi H, Oguma K, Niwa K, Ohyama T, Watanabe T.  HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer.  FEMS Immunol. Med. Microbiol.  2011  61:323-31  PubMed ID: 21219447   DOI: 10.1111/j.1574-695X.2011.00779.x
8245  Takeda K, Hashimoto K, Uchikawa R, Tegoshi T, Yamada M, Arizono N.  Direct effects of IL-4/IL-13 and the nematode Nippostrongylus brasiliensis on intestinal epithelial cells in vitro.  Parasite Immunol.  2010  32:420-9  PubMed ID: 20500673   DOI: 10.1111/j.1365-3024.2010.01200.x
8339  Sato N, Morimoto H, Baba R, Nakamata J, Doi Y, Yamaguchi K.  Functional expression of double-stranded RNA-dependent protein kinase in rat intestinal epithelial cells.  J. Cell. Biochem.  2010  110:104-11  PubMed ID: 20213745   DOI: 10.1002/jcb.22513
8361  Takada M, Otaka M, Takahashi T, Izumi Y, Tamaki K, Shibuya T, Sakamoto N, Osada T, Yamamoto S, Ishida R, Odashima M, Itoh H, Watanabe S.  Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells.  Life Sci.  2010  86:499-504  PubMed ID: 20159025   DOI: 10.1016/j.lfs.2010.02.010
8485  Niwa K, Yoneyama T, Ito H, Taira M, Chikai T, Kouguchi H, Suzuki T, Hasegawa K, Miyata K, Inui K, Ikeda T, Watanabe T, Ohyama T.  Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells.  Vet. Microbiol.  2010  141:312-20  PubMed ID: 19786330   DOI: 10.1016/j.vetmic.2009.09.008
12756  Inui K, Ito H, Miyata K, Matsuo T, Horiuchi R, Ikeda T, Watanabe T, Ohyama T, Niwa K.  Involvement of sialic acid in transport of serotype C1 botulinum toxins through rat intestinal epithelial cells  J Vet Med Sci  2010  72(9):1251-5  PubMed ID: 20453451   DOI: 10.1292/jvms.10-0090
12806  Shoji H, Oguchi S, Shinohara K, Shimizu T, Yamashiro Y.  Effects of iron-unsaturated human lactoferrin on hydrogen peroxide-induced oxidative damage in intestinal epithelial cells  Pediatr Res  2007  61(1):89-92.  PubMed ID: 17211147   DOI: 10.1203/01.pdr.0000250198.22735.20
3877  Yuki T, Ishihara S, Rumi MA, Ortega-Cava CF, Kadowaki Y, Kazumori H, Ishimura N, Amano Y, Moriyama N, Kinoshita Y.  Increased expression of midkine in the rat colon during healing of experimental colitis.  Am J Physiol Gastrointest Liver Physiol  2006  291(4):G735-43  PubMed ID: 16959957   DOI: 10.1152/ajpgi.00388.2005
3408  Qian, Wei, Nishikawa, Manabu, Haque, Anwarul Md, Hirose, Masaki, Mashimo, Masayuki, Sato, Eisuke, Inoue, Masayasu  Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death.  Am J Physiol Cell Physiol  2005  289:C1466-75  PubMed ID: 16107504   DOI: 10.1152/ajpcell.00265.2005
2907  Uesaka T, Kageyama N, Watanabe H  Identifying target genes regulated downstream of Cdx2 by microarray analysis.  J Mol Biol  2004  337:647-60  PubMed ID: 15019784   DOI: 10.1016/j.jmb.2004.01.061
2864  Ikenoue, Tsuneo, Hikiba, Yohko, Kanai, Fumihiko, Aragaki, Jun, Tanaka, Yasuo, Imamura, Jun, Imamura, Takaaki, Ohta, Miki, Ijichi, Hideaki, Tateishi, Keisuke, Kawakami, Takayuki, Matsumura, Masayuki, Kawabe, Takao, Omata, Masao  Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.  Cancer Res  2004  64:3428-35  PubMed ID: 15150094   DOI: 10.1158/0008-5472.CAN-03-3591
3178  Uesaka, Toshihiro, Kageyama, Noriko  Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.  FEBS Lett  2004  573:147-54  PubMed ID: 15327990   DOI: 10.1016/j.febslet.2004.07.070
18572  Kuroda A, Uchikawa R, Matsuda S, Yamada M, Tegoshi T, Arizono N.  Up-regulation of Fas (CD95) and induction of apoptosis in intestinal epithelial cells by nematode-derived molecules  Infect Immun  2002  70(8):4002-8  PubMed ID: 12117905   DOI: 10.1128/IAI.70.8.4002-4008.2002
18647  Yoshida S, Kajimoto Y, Yasuda T, Watada H, Fujitani Y, Kosaka H, Gotow T, Miyatsuka T, Umayahara Y, Yamasaki Y, Hori M.  PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells  Diabetes  2002  51(8):2505-13  PubMed ID: 12145164   DOI: 10.2337/diabetes.51.8.2505
3789  Uesaka T, Lu H, Katoh O, Watanabe H.  Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.  Am J Physiol Gastrointest Liver Physiol  2002  283(4):G840-7  PubMed ID: 12223343   DOI: 10.1152/ajpgi.00075.2002
3832  Mizuno M, Okayama N, Kasugai K, Yoshida T, Miyata M, Nitta M, Kataoka H, Akita S, Joh T, Itoh M, Asai K, Kato T.  Acid stimulates E-cadherin surface expression on gastric epithelial cells to stabilize barrier functions via influx of calcium.  Eur J Gastroenterol Hepatol.  2001  13(2):127-36  PubMed ID: 11246611   DOI: 10.1097/00042737-200102000-00007
3809  Hassan S, Kinoshita Y, Okada A, Maekawa T, Fukui H, Chiba T.  Geranylgeranylacetone, an anti-ulcer drug, stimulates hexosamine production in a rat gastric mucosal cell line through binding to a specific cytosolic protein.  J Gastroenterol Hepatol.  1998  13(8):809-15  PubMed ID: 9736174   DOI: 10.1111/j.1440-1746.1998.tb00737.x

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