| 利用者成果(英) |
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17773
Watanabe K, Negoro R, Fujita T.
5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells
Biochem Biophys Res Commun
2023
664:94-99
PubMed ID: 37141642
DOI: 10.1016/j.bbrc.2023.04.077
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17774
Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H.
Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells
Biosci Biotechnol Biochem
2023
zbad030
PubMed ID: 36941128
DOI: 10.1093/bbb/zbad030
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|
17775
Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima
The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells
J. Excipients and Food Chem
2023
14:22-32
|
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17776
Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.
Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels
BMC Cancer
2023
23(1):356
PubMed ID: 37072777
DOI: 10.1186/s12885-023-10845-y
|
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17778
Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα
Drug Metabolism and Pharmacokinetics
2023
DOI: 10.1016/j.dmpk.2023.100512
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17779
Sansawat, A., Ratanacoon, M. and Nitteranon, V.
Antioxidative, anti-inflammatory, antibacterial, and anti- adhesive activities of different solvent extracts from various parts of Basella rubra L.
International Journal of Agricultural Technology
2023
19(2):655-668
|
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17780
Zhu Q, Iwai R, Okaguchi T, Shirasaka Y, Tamai I.
Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT
Food Funct
2023
May 2
PubMed ID: 37129213
DOI: 10.1039/d3fo00510k
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13874
Yamada N, Negoro R, Watanabe K, Fujita T.
Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system
Drug Metab Pharmacokinet
2023
50:100497.
PubMed ID: 37037169
DOI: 10.1016/j.dmpk.2023.100497
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21020
Kudo K, Kobayashi T, Kasai K, Nozaka H, Nakamura T.
Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α.
Biochem Biophys Res Commun
2023
642:185-191
PubMed ID: 36586186
DOI: 10.1016/j.bbrc.2022.12.051
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21021
Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T.
Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Biochim Biophys Acta Mol Cell Res
2023
1870(2):119404
PubMed ID: 36535369
DOI: 10.1016/j.bbamcr.2022.119404
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21182
Tsubaki M, Takeda T, Matsuda T, Kishimoto K, Takefuji H, Taniwaki Y, Ueda M, Hoshida T, Tanabe K, Nishida S.
Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy.
Cancer Cell Int
2023
23(1):73
PubMed ID: 37069612
DOI: 10.1186/s12935-023-02884-z
|
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21203
Kuriya K, Goto S, Kobayashi E, Nishio M, Nakamura M, Umekawa H.
Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols.
Mol Biol Rep
2023
PubMed ID: 37160631
DOI: 10.1007/s11033-023-08481-7
|
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21281
Lyu M, Bai Y, Orihara K, Miyanaga K, Yamamoto N.
GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions.
Microorganisms
2023
11(6)
PubMed ID: 37374895
DOI: 10.3390/microorganisms11061393
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21285
Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E.
Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.
Biochem Biophys Res Commun
2023
672:72-80
PubMed ID: 37343317
DOI: 10.1016/j.bbrc.2023.06.017
|
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21307
Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.
Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.
Ann Surg Oncol
2023
PubMed ID: 37407874
DOI: 10.1245/s10434-023-13779-8
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21310
Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T.
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
J Gastroenterol
2023
PubMed ID: 37410250
DOI: 10.1007/s00535-023-02016-4
|
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21358
Yamaguchi R, Kanie Y, Kazamaki T, Kanie O, Shimizu Y.
Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells.
Carbohydr Res
2023
532:108921
PubMed ID: 37562111
DOI: 10.1016/j.carres.2023.108921
|
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21419
Shibamoto A, Kaji K, Nishimura N, Kubo T, Iwai S, Tomooka F, Suzuki J, Tsuji Y, Fujinaga Y, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin.
J Nutr Biochem
2023
109450
PubMed ID: 37777163
DOI: 10.1016/j.jnutbio.2023.109450
|
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21424
Kataoka M, Kitazawa M, Nakamura S, Koyama M, Yamamoto Y, Miyazaki S, Hondo N, Tanaka H, Soejima Y.
Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment.
Anticancer Res
2023
43(10):4341-4348
PubMed ID: 37772552
DOI: 10.21873/anticanres.16629
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21445
Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M.
Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.
Pharmaceutics
2023
15(9)
PubMed ID: 37765306
DOI: 10.3390/pharmaceutics15092338
|
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21455
Hiranphinyophat S, Hiraoka T, Kobayashi M, Fujii S, Kishida A, Tanabe T, Kimura T, Yamamoto M.
Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies.
Langmuir
2023
PubMed ID: 37882450
DOI: 10.1021/acs.langmuir.3c01858
|
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21494
Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine.
Biol Pharm Bull
2023
46(12):1745-1752
PubMed ID: 38044133
DOI: 10.1248/bpb.b23-00479
|
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17506
Hashizume J, Sato K, Nakagawa H, Harasawa H, Honda T, Kodama Y.
Examination of the Effect of Proton Pump Inhibitors on the Anticancer Activity of Oxaliplatin
Cancer Diagn Progn
2022
2(6):620-626
PubMed ID: 36340458
DOI: 10.21873/cdp.10151
|
|
17564
Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells
Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells
Journal of Applied Pharmaceutical Science
2022
147-159
DOI: 10.7324/japs.2022.120715
|
|
17586
Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, Yamaji R.
Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide
J Agric Food Chem
2022
70(49):15499-15508
PubMed ID: 36458736
DOI: 10.1021/acs.jafc.2c06791
|
|
14784
Ariumi Y.
Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection
J Virol
2022
96(6):e0000222
PubMed ID: 35107372
DOI: 10.1128/jvi.00002-22
|
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15564
Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T.
Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system
Arch Toxicol
2022
Oct 16
PubMed ID: 34654938
DOI: 10.1007/s00204-021-03175-0
|
|
20541
Shinji S, Shichi Y, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Yonaga K, Iwai T, Takeda K, Ueda K, Kuriyama S, Miyasaka T, Ueda Y, Sasaki N, Takahashi K, Ohashi R, Ishiwata T, Arai T, Yoshida H.
A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor
J Nippon Med Sch
2022
89(4):368-376
PubMed ID: 35082206
DOI: 10.1272/jnms.JNMS.2022_89-402
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16347
Naoki Murata, Saki Keitoku, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata
Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers
Natural Product Communications
2022
17:1934578X2110704
DOI: 10.1177/1934578x211070415
|
|
16348
Inada A, Sawao A, Takahashi K, Oshima T.
Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate
J Food Sci
2022
87(3):1174-1183
PubMed ID: 35122241
DOI: 10.1111/1750-3841.16049
|
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16349
Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S.
PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells
Oncol Lett
2022
23(4):106
PubMed ID: 35242234
DOI: 10.3892/ol.2022.13226
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|
20603
Diao X, Yamada K, Shibata Y, Imada C.
Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide.
Mar Drugs
2022
20(2)
PubMed ID: 35200617
DOI: 10.3390/md20020087
|
|
20610
Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.
TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.
Biochem Biophys Rep
2022
30:101239
PubMed ID: 35252596
DOI: 10.1016/j.bbrep.2022.101239
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|
20640
Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A.
Indigo plant leaf extract inhibits the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2.
Exp Ther Med
2022
23(4):274
PubMed ID: 35251340
DOI: 10.3892/etm.2022.11200
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|
20686
Enomoto M, Kaji K, Nishimura N, Fujimoto Y, Murata K, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.
Dig Liver Dis
2022
PubMed ID: 35514019
DOI: 10.1016/j.dld.2022.04.012
|
|
20699
Takahashi Y, Abe H, Koayama K, Koseki S.
Modeling the invasion of human small intestinal epithelial-like cells by Salmonella enterica Typhimurium and Listeria monocytogenes using Bayesian inference.
Lett Appl Microbiol
2022
PubMed ID: 35575530
DOI: 10.1111/lam.13738
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16510
Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu
Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation
Toxicology Reports
2022
9:937-944
PubMed ID: 35875256
DOI: 10.1016/j.toxrep.2022.04.019
|
|
20749
Takizawa Y, Nakamura R, Kurita T, Nakajima T.
Lactose hydrate can increase the transcellular permeability of β-naphthol in rat jejunum and ileum.
Mol Biol Rep
2022
PubMed ID: 35767107
DOI: 10.1007/s11033-022-07709-2
|
|
16737
Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima
Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells
Scholars Academic Journal of Pharmacy
2022
11:60-66
DOI: 10.36347/sajp.2022.v11i04.002
|
|
16738
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama
Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding
BPB Reports
2022
5:66-69
DOI: 10.1248/bpbreports.5.3_66
|
|
16739
Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.
Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles
J Biotechnol
2022
354:34-44
PubMed ID: 35724765
DOI: 10.1016/j.jbiotec.2022.06.006
|
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16742
Kawahara T, Shimizu I, Tanaka Y, Tobita K, Tomokiyo M, Watanabe I.
Lactobacillus crispatus Strain KT-11 S-Layer Protein Inhibits Rotavirus Infection
Front Microbiol
2022
13:783879
PubMed ID: 35273580
DOI: 10.3389/fmicb.2022.783879
|
|
20798
Onuma S, Kinoshita S, Shimba S, Ozono K, Michigami T, Kawai M.
The lack of Bmal1, a core clock gene, in the intestine decreases glucose absorption in mice.
Endocrinology
2022
PubMed ID: 35904419
DOI: 10.1210/endocr/bqac119
|
|
20829
Sakakibara Y, Kojima A, Asai Y, Nadai M, Katoh M.
Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid.
Biopharm Drug Dispos
2022
PubMed ID: 36000181
DOI: 10.1002/bdd.2328
|
|
20956
Satow R, Suzuki Y, Asada S, Ota S, Idogawa M, Kubota S, Ikeo N, Yoneda A, Fukami K.
Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells.
iScience
2022
25(12):105501
PubMed ID: 36404918
DOI: 10.1016/j.isci.2022.105501
|
|
20966
Akino S, Yasujima T, Yamashiro T, Yuasa H.
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter.
Life Sci Alliance
2022
6(2)
PubMed ID: 36456177
DOI: 10.26508/lsa.202201629
|
|
17777
Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima
The influence of 4-methylimidazole on the gastrointestinal epithelial cells
J. Excipients and Food Chem
2021
12:4-15
|
|
12864
Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M.
Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy
Biol Trace Elem Res
2021
199(9):3272-3286
PubMed ID: 33236292
DOI: 10.1007/s12011-020-02463-7
|
|
20031
Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin.
Biol Pharm Bull
2021
44(2):275-278
PubMed ID: 33518681
DOI: 10.1248/bpb.b20-00644
|
|
13512
Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I.
Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase
mBio
2021
12(1):e01974-20
PubMed ID: 33563838
DOI: 10.1128/mBio.01974-20
|
|
13556
Zhu Q, Komori H, Imamura R, Tamai I.
A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT
J Pharm Sci
2021
110(3):1392-1400
PubMed ID: 33278408
DOI: 10.1016/j.xphs.2020.11.030
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|
20064
Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S.
Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.
Eur J Pharmacol
2021
898:173957
PubMed ID: 33662352
DOI: 10.1016/j.ejphar.2021.173957
|
|
20066
Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y.
Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
Lipids Health Dis
2021
20(1):24
PubMed ID: 33648494
DOI: 10.1186/s12944-021-01448-2
|
|
20080
Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T.
Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.
Int J Environ Res Public Health
2021
18(4)
PubMed ID: 33671655
DOI: 10.3390/ijerph18042126
|
|
20149
Igarashi F, Nakagawa T, Shinohara Y, Tachibana T.
Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.
Pharm Res
2021
Pharm Res
PubMed ID: 34009624
DOI: 10.1007/s11095-021-03054-4
|
|
14514
Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M.
An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement
PLoS One
2021
16(6):e0253066
PubMed ID: 34115818
DOI: 10.1371/journal.pone.0253066
|
|
14782
Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A.
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Sci Rep
2021
11(1):5376
PubMed ID: 33686154
DOI: 10.1038/s41598-021-84882-7
|
|
14786
Sasaki M, Uemura K, Sato A, Toba S, Sanaki T, Maenaka K, Hall WW, Orba Y, Sawa H.
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
PLoS Pathog
2021
17(1):e1009233
PubMed ID: 33476327
DOI: 10.1371/journal.ppat.1009233
|
|
20226
Chowdhury MMI, Tomii A, Ishii K, Tahara M, Hitsuda Y, Koto Y, Kurata K, Yuasa K, Nishimura K, Shimizu H.
TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells.
Biosci Biotechnol Biochem
2021
PubMed ID: 34245564
DOI: 10.1093/bbb/zbab128
|
|
15106
Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N.
Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted fr
Food Chem
2021
360:129822
PubMed ID: 33984564
DOI: 10.1016/j.foodchem.2021.129822
|
|
15149
Gen Toshima, Takanobu Kiuchi, Yuka Iwama, Haruna Ohrui, Fumiko Kimura, Shiho Nakagawa, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata, Junichiro Takahashi
Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki)
Journal of Biological Macromolecules
2021
21:33-44
DOI: 10.14533/jbm.21.33
|
|
20270
Nguma E, Yamashita S, Kumagai K, Otoki Y, Yamamoto A, Eitsuka T, Nakagawa K, Miyazawa T, Kinoshita M.
Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress.
ACS Omega
2021
6(4):3140-3148
PubMed ID: 33553930
DOI: 10.1021/acsomega.0c05545
|
|
20293
Arai M, Komori H, Fujita D, Tamai I.
Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
Pharm Res
2021
38(3):523-530
PubMed ID: 33723795
DOI: 10.1007/s11095-021-03018-8
|
|
20300
Kitazawa M, Miyagawa Y, Koyama M, Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu D, Takeoka M, Soejima Y.
Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL.
Mol Clin Oncol
2021
15(1):148
PubMed ID: 34094546
DOI: 10.3892/mco.2021.2310
|
|
15288
Akihiro Nishiguchi, Tetsushi Taguchi
Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis
Advanced Functional Materials
2021
2100548
DOI: 10.1002/adfm.202100548
|
|
15412
Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.
Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer
Cancer Sci
2021
112(8):3173-3189
PubMed ID: 34008277
DOI: 10.1111/cas.14969
|
|
20369
Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K.
Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.
Mol Ther Nucleic Acids
2021
PubMed ID: 34692233
DOI: 10.1016/j.omtn.2021.10.016
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|
20384
Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.
Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Mol Pharm
2021
PubMed ID: 34734526
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Heliyon
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5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
iScience
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Foods
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Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
Saudi J Biol Sci
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Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation
Front Oncol9
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Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity
J Agric Food Chem
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Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity
World J Gastroenterol
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Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A.
Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells
Chem Biol Interact
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Drug Metab Dispos
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Abdelbasset Boubakri, Hanen Najjaa, Hanane Maghrebi, Abdelkarim Ben Arfa, Marcos Antonio Das Neves, Hiroko Isoda, Mitsutoshi Nakajima, Mohamed Neffati
Effect of freeze‐drying on the antioxidant and the cytotoxic properties of Allium roseum L. and its application in stabilizing food emulsions
Journal of Food Processing and Preservation
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Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies
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Mater Sci Eng C Mater Biol Appl
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YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung
Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells
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J. Cell. Biochem
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Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells.
Planta Med.
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BMC Microbiol.
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Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.
Bioorg Med Chem
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Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
Carbohydr Polym
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Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S.
10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.
Biol Pharm Bull
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Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.
Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.
J Oleo Sci
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Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y.
Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.
Int J Oncol
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Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.
Biochem Biophys Rep
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Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.
Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
Biochem Biophys Res Commun
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Yamashiro T, Yasujima T, Said HM, Yuasa H.
pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.
J Biol Chem
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Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.
Appl Environ Microbiol
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Nagata Y, Yamamoto T, Kadowaki M.
Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.
J Nutr Sci Vitaminol (Tokyo)
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Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi
Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph
BMC
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Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M.
Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route
J Membr Biol
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253(3):221-228
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Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T.
Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice
Cancer Sci
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Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M.
Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro
J Oleo Sci
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Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats
Front Pharmacol
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Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1
Journal of Functional Foods
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Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids
Eur J Pharm Sci
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A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays
Biomater Sci
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A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation
Biol Pharm Bull
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Li Z, Zheng J, Luo X, Manabe Y, Hirata T, Sugawara T.
Absorption and Tissue Distribution of Siphonaxanthin from Green Algae
Mar Drugs
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Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N.
Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria
Vaccine
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Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu
New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus
Phytochemistry Letters
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Mol. Biochem. Parasitol.
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Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.
J Pharm Sci
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Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.
Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
Biochem. Biophys. Res. Commun.
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Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N.
A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing.
Sci Rep
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Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.
Biochim Biophys Acta Mol Cell Biol Lipids
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PubMed ID: 31351225
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Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki
Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose
Natural Product Communications
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Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.
Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.
Lipids
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Numata T, Sato-Numata K, Okada Y.
Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.
Sci Rep
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Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.
Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.
Cancer Sci
2019
110(12):3708-3717
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Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.
Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.
Nutr Res
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72:92-104
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Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.
Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.
Pharm Res
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37(1):13
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Mahmoud Abdel-Hamid et al
The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage
International Dairy Journal
2019
91:1-8
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Matsuzaki T, Nakamura M, Nogita T, Sato A.
Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.
Biol Pharm Bull
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42(6):989-995
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Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome
Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha
iosci Microbiota Food Health
2019
38(1):11-22
PubMed ID: 30705798
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Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2
CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin
Mol Cell Biol
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39(16):e00073-19
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Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
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10420
Sanae Yoshimoto, Keiko Okada, Osamu Hayashi
Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier
Functional Foods in Health and Disease
2019
9(7):466-483
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Selma Etteieb Jamila Tarhouni Hiroko Isoda
Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures
Water and Environment Journal
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33:4-13
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Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients
Journal of Functional Foods
2019
55:352-361
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Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.
Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.
Cancers (Basel)
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PubMed ID: 31769426
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Matsumoto A, Watanabe C, Murakami M.
Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.
Drug Discov Ther
2019
PubMed ID: 31956233
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Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
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Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
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33(2):189-195
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Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.
Biochim. Biophys. Acta
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Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Toxicol In Vitro
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46:284-293
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Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.
Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.
Glycobiology
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28:21-31
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Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.
Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
Arch. Biochem. Biophys.
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The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
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Exp. Anim.
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J Nat Med
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A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.
Sci Rep
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Sci Rep
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Mol. Pharm.
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Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.
Anal Sci
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Inflamm. Res.
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TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma
Oncotarget
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miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.
BMC Cancer
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Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.
Biochem. Biophys. Res. Commun.
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Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.
Int J Mol Sci
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Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.
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Cytotechnology
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Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.
Oncol Lett
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Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
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Am. J. Chin. Med.
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J Oleo Sci
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Journal of Functional Foods
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1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis
Nutrition Research
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Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells
Journal of Functional Foods
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Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity
Food Science and Technology Research
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A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.
Lab Chip
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Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto
Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers
J Clin Biochem Nutr
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Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga
Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes
Biochem Biophys Res Commun
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Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita
Design and fabrication of devices for investigating cell-sheet stretch
BioChip Journal
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Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells
Int J Oncol
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Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity
J Gastroenterol Hepatol
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32(11):1839-1845
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Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito
Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications
Front Physiol
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Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.
Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism
Kidney Int
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Acta Biomater
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Sci Rep
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Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.
J Nat Med
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Pharm Biol
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Lipids
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Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
J. Biol. Chem.
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J. Pharm. Pharmacol.
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H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.
Biochem. Biophys. Res. Commun.
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Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.
Oxid Med Cell Longev
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Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water
Water, Air, & Soil Pollution
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The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.
Int J Mol Sci
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Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama
Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis
PLoS One
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Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa
The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro
J Vet Med Sci
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Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone
Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells
Nutr Res .
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Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen
Biopharm Drug Dispos
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Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara
An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1
Biol Pharm Bull .
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Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu
New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Phytochemistry Letters
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Effect of dietary fibers on losartan uptake and transport in Caco-2 cells
Biopharm Drug Dispos
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Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
Journal of Functional Foods
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Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation
PLoS Genet
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Pharmacology
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Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.
Deep Ocean Water Research
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Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura
Enhanced Oleate Uptake and Lipotoxicity Associated With Laurate
FEBS Open Bio . 2015 May 29;5:485-91
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Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura
Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice
Exp Cell Res
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Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto
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Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
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Drug Metab Pharmacokinet
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Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato
Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life
Eur J Pharm Sci
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Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki
Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy
J Control Release
2015
210:19-25
PubMed ID: 25998050
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9993
Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami
Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption
J Nutr Sci Vitaminol (Tokyo)
2015
61(6):449-54
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10154
Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab
Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines
Energy Procedia
2015
74:878 – 885
DOI: 10.1016/j.egypro.2015.07.823
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10156
Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe
Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity
J Ethnopharmacol
2015
161:147-55
PubMed ID: 25523370
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10157
Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano
The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells
J Cell Mol Med
2015
19(7):1569-81
PubMed ID: 25689483
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10158
Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida
Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer
Mol Clin Oncol
2015
3(5):1080-1084
PubMed ID: 26623054
DOI: 10.3892/mco.2015.577
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10159
Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota
Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas
Oncology
2015
88(5):309-19
PubMed ID: 25591719
DOI: 10.1159/000369905
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10160
Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa
Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation
J Biol Chem
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PubMed ID: 26023238
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10172
Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham
Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats
Nanomedicine
2015
11(5):1227-36
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14459
Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.
MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells
PLoS One
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10(5):e0127119
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15177
Ozeki K, Kato M, Sakurai Y, Ishigai M, Kudo T, Ito K.
Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study
Int J Pharm
2015
495(2):963-71
PubMed ID: 26387619
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17443
Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T.
An on-chip small intestine-liver model for pharmacokinetic studies
J Lab Autom
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20(3):265-73
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Shimozato O, Waraya M, Nakashima K, Souda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T.
Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation
Oncogene
2015
34(15):1949-60
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10196
Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi
Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats
PLoS One
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9(5):e97901
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10198
Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo
Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells
Food Chem
2014
154:145-50
PubMed ID: 24518326
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10199
Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo
Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells
Pestic Biochem Physiol .
2014
111:38-42
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10202
Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki
Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells
Biol Pharm Bull
2014
37(3):490-2
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10203
Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi
Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO)
Life Sci .
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107(1-2):14-20
PubMed ID: 24792517
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10204
Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo
Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters
Biol Pharm Bull .
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37(9):1475-9
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10208
Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani
Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption
Drug Metab Pharmacokinet
2014
29(5):414-8
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10209
Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura
Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation
FEBS Lett .
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588(11):1997-2002
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10223
Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto
Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases
Cancer Chemother Pharmacol
2014
74(5):1023-8
PubMed ID: 25205428
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10224
Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto
Induction of AhR-mediated Gene Transcription by Coffee
PLoS One
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9(7):e102152
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10225
Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin
Drug Metab Pharmacokinet
2014
29(4):312-6
PubMed ID: 24492671
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10226
Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki
Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion
J Pharm Pharm Sci
2014
17(2):266-76
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10229
Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto
Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin
Biopharm Drug Dispos
2014
35(6):321-9
PubMed ID: 24801141
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10237
Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi
Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures
Tumour Biol
2014
35(12):12689-93
PubMed ID: 25217322
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10242
T Nakayama, K Ezoe
Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O
Curr Microbiol .
2014
69(5):690-8
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10243
Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki
Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke
Sci Technol Adv Mater
2014
15(3):035002
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10244
Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation
Immunol Cell Biol
2014
92(7):624-30
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10254
Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi
Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells
J Clin Biochem Nutr
2014
55(3):162-7
PubMed ID: 25411520
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10259
Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure
Electric Stimulus Opens Intercellular Spaces in Skin
J Biol Chem
2014
24;289(4):2450-6
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10262
Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane
Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D
FEMS Microbiol Lett
2014
2014 Aug;357(2):115-22
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16629
Sakai T, Mashima H, Yamada Y, Goto T, Sato W, Dohmen T, Kamada K, Yoshioka M, Uchinami H, Yamamoto Y, Ohnishi H.
The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer
Pancreas
2014
43(6):909-16
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Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.
Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.
Biochim Biophys Acta
2013
1832(1):151-9
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12694
Isshiki M, Ohta H, Tamura H.
Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells
Biol Pharm Bull
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36(2):299-304
PubMed ID: 23370358
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Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H.
Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells
J Pharm Pharmacol
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65(1):22-9
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Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K.
An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells
3 Biotech
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3(3):213-218
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Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J.
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
World J Gastroenterol
2013
19(33):5500-7
PubMed ID: 24023493
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12698
Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H.
Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes
Biol Pharm Bull
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36(11):1862-6
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Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.
Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
J Biol Chem
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288(19):13317-24
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Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.
INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors
Biochem Biophys Res Commun
2013
432(4):586-92
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Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J.
Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery
Eur J Pharm Sci
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50(3-4):303-11
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Kamishikiryo J, Matsumura R, Takamori T, Sugihara N.
Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid
J Pharm Pharmacol
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65(7):1037-43
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Kimura R, Rokkaku T, Takeda S, Senba M, Mori N.
Cytotoxic effects of fucoidan nanoparticles against osteosarcoma
Mar Drugs
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11(11):4267-78
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Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.
Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections
Microb Pathog
2013
65:14-20
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Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N.
Dlg5 interacts with the TGF-β receptor and promotes its degradation
FEBS Lett
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587(11):1624-9
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Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K.
Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides
Int Immunopharmacol
2013
17(4):1009-19
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Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.
Possible involvement of Wnt11 in colorectal cancer progression
Mol Carcinog
2013
52(3):207-17
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Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.
Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers
Proc Natl Acad Sci U S A
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110(6):2105-10
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KATSUHITO ARAI – TAMIKO YAMAZAKI – YOSHIHIKO TOKUJI – MIKA KAWAHARA – KIYOSHI OHBA – KAZUNORI HIRONAKA – MIKIO KINOSHITA – MASAO OHNISHI
Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice
Journal of Food and Nutrition Research
2013
52:139–145
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15925
Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S.
Relationship between methyl CpG binding protein 2 and JC viral proteins
Jpn J Infect Dis
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66(2):126-32.
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Kimura O, Tsukagoshi K, Hayasaka M, Endo T.
Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.
Basic Clin. Pharmacol. Toxicol.
2012
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Ito N, Ohtsubo T, Kusu F, Hakamata H.
An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells.
Anal. Biochem.
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421:86-91
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Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F.
Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
Int J Oncol
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40(1):217-26
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Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto
Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells
J Med Food
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15(6):511-9
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Kimura O, Tsukagoshi K, Hayasaka M, Endo T.
Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells
Arch Toxicol
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86(1):55-61
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Yanagihara S, Hirota T, Yamamoto N.
Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells
J Biosci Bioeng
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114(6):582-5
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Matsuo Y, Miyoshi Y, Okada S, Satoh E.
Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri
Biosci Microbiota Food Health
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31(4):93-102
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Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M.
CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer
Eur J Cancer
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48(14):2244-51.
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Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K.
Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins
Acta Med Okayama
2012
66(3):253-61
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12716
Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K.
Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein
J Pharm Pharm Sci
2012
15(2):256-64
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Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.
Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine
J Sci Food Agric
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92(4):857-61
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Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M.
Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients
Ann Surg Oncol
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19 Suppl 3:S518-27
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Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K.
Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP
J Pharm Pharm Sci
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15(2):295-304
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Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO
Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu”
Food Science and Technology Research
2012
18:825-834
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Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N.
Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate
J Food Sci
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77(10):H208-15
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Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.
A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers
Biol Pharm Bull
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35(1):1-9
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Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat
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Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M.
TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation
World J Gastroenterol
2007
13(19):2717-21
PubMed ID: 17569141
DOI: 10.3748/wjg.v13.i19.2717
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12804
Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y.
Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2007
30(10):1930-3
PubMed ID: 17917264
DOI: 10.1248/bpb.30.1930
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12805
Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.
Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro
Am J Physiol Gastrointest Liver Physiol
2007
292(3):G923-9
PubMed ID: 17170030
DOI: 10.1152/ajpgi.00145.2006
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12807
Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E.
Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells
J Biol Chem
2007
282(10):7742-52
PubMed ID: 17204466
DOI: 10.1074/jbc.M611382200
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12810
Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki
Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats
Asian-Australasian Journal of Animal Sciences
2007
20(7): 1120-1126
DOI: 10.5713/ajas.2007.1120
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12811
Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T.
Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport
J Pharm Pharmacol
2007
59(10):1383-7
PubMed ID: 17910813
DOI: 10.1211/jpp.59.10.0008
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3432
Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro
In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.
Drug Metab Dispos
2006
34:369-74
PubMed ID: 16326817
DOI: 10.1124/dmd.105.006213
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3404
Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao
Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.
J Pharm Sci
2006
95:552-60
PubMed ID: 16419049
DOI: 10.1002/jps.20563
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8890
Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.
Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.
Biol. Pharm. Bull.
2006
29:535-8
PubMed ID: 16508161
DOI: 10.1248/bpb.29.535
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12816
Han Y, Tan TM, Lim LY.
Effects of capsaicin on P-gp function and expression in Caco-2 cells
Biochem Pharmacol
2006
71(12):1727-34
PubMed ID: 16674925
DOI: 10.1016/j.bcp.2006.03.024
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12817
Watanabe K, Jinriki T, Sato J.
Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2
Biol Pharm Bull
2006
29(1):90-5
PubMed ID: 16394517
DOI: 10.1248/bpb.29.90
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12818
Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T.
Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells
Biosci Biotechnol Biochem
2006
70(12):2906-12
PubMed ID: 17151482
DOI: 10.1271/bbb.60318
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12819
Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K.
Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers
J Pharm Sci
2006
95(6):1393-401
PubMed ID: 16625653
DOI: 10.1002/jps.20616
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12820
M Gueimonde et al
Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli
Food Research International
2006
39:467-471
DOI: 10.1016/j.foodres.2005.10.003
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12821
Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.
Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer
Toxicology
2006
223(1-2):156-65
PubMed ID: 16647797
DOI: 10.1016/j.tox.2006.03.011
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12822
Ishida K, Takaai M, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2006
29(3):522-6
PubMed ID: 16508158
DOI: 10.1248/bpb.29.522
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12823
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Food Science and Technology Research
2006
12:290-294
DOI: 10.3136/fstr.12.290
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12824
Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
J Gastroenterol
2006
2006 Feb;41(2):140-50
PubMed ID: 16568373
DOI: 10.1007/s00535-005-1733-6
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12825
Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.
Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
Hepatol Res
2006
35(3):152-62
PubMed ID: 16707273
DOI: 10.1016/j.hepres.2006.03.011
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12826
Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.
Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli
Protein Expr Purif
2006
47(1):144-51
PubMed ID: 16307894
DOI: 10.1016/j.pep.2005.10.011
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12827
Makoto KIMURA, Kuninaga DANNO, Hisako YASUI
Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk
Bioscience and Microflora
2006
25:147-155
DOI: 10.12938/bifidus.25.147
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12828
Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.
Determination of p-glycoprotein ATPase activity using luciferase
Biol Pharm Bull
2006
29(3):560-4
PubMed ID: 16508168
DOI: 10.1248/bpb.29.560
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3026
Aiba T, Susa M, Fukumori S, Hashimoto Y
The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180
Drug Metab Pharmacokinet
2005
20:268-274
PubMed ID: 16141606
DOI: 10.2133/dmpk.20.268
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3025
Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya
Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.
Biol Pharm Bull
2005
28:114-9
PubMed ID: 15635174
DOI: 10.1248/bpb.28.114
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3072
Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru
Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.
Biosci Biotechnol Biochem
2005
69:202-5
PubMed ID: 15665486
DOI: 10.1271/bbb.69.202
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3300
Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.
Biol Pharm Bull
2005
28:527-30
PubMed ID: 15744083
DOI: 10.1248/bpb.28.527
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3155
Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu
Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.
Int J Vitam Nutr Res
2005
75:39-46
PubMed ID: 15830920
DOI: 10.1024/0300-9831.75.1.39
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3164
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Biochemistry
2005
44:6343-9
PubMed ID: 15835923
DOI: 10.1021/bi047606a
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3270
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
Hepatol. Res.
2005
33:198-205
PubMed ID: 16198622
DOI: 10.1016/j.hepres.2005.08.005
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9134
Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.
CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS
Chiang Mai Med Bull
2005
44:21-28
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9048
Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye
Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines
J Agric Food Chem
2005
53 (16), 6313-8
PubMed ID: 16076112
DOI: 10.1021/jf0506129
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12832
Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2
Food Science and Technology Research
2005
11:202-206
DOI: 10.3136/fstr.11.202
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12833
Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.
The effects of coffee on conjugation reactions in human colon carcinoma cells
Biol Pharm Bull
2005
28(2):271-4
PubMed ID: 15684482
DOI: 10.1248/bpb.28.271
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12835
Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.
Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
Biochim Biophys Acta
2005
1732(1-3):43-52
PubMed ID: 16380173
DOI: 10.1016/j.bbaexp.2005.11.003
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2720
Saegusa S, Totsuka M, Kaminogawa S, Hosoi T
Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.
FEMS Immunol Med Microbiol
2004
41:227-35
PubMed ID: 15196572
DOI: 10.1016/j.femsim.2004.03.006
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2736
Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi
Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.
Eur J Pharm Sci
2004
21:87-95
PubMed ID: 14706815
DOI: 10.1016/j.ejps.2003.10.002
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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2735
Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi
Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.
Biol Pharm Bull
2004
27:559-63
PubMed ID: 15056866
DOI: 10.1248/bpb.27.559
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3199
Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji
Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.
Am J Physiol Cell Physiol
2004
287:C1404-11
PubMed ID: 15229109
DOI: 10.1152/ajpcell.00471.2003
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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3094
Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Cancer Res
2004
64:6410-5
PubMed ID: 15374948
DOI: 10.1158/0008-5472.CAN-04-1543
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2708
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.
Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.
J. Exp. Clin. Cancer Res.
2004
23:69-75
PubMed ID: 15149153
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3066
Aida K. et al.
Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.
J Oleo Sci.
2004
53:503-510
DOI: 10.5650/jos.53.503
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4723
Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.
Oncol Res
2004
14(9):407-14
PubMed ID: 15490972
DOI: 10.3727/0965040041791464
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12839
Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.
Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells
Biosci Biotechnol Biochem
2004
68(12):2541-6
PubMed ID: 15618625
DOI: 10.1271/bbb.68.2541
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12840
Shigeaki Okamura, Hiro-omi Tamura
Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2
Journal of Health Science
2004
50:189-192
DOI: 10.1248/jhs.50.189
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
DOI: 10.1177/026119290403201s15
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12843
Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.
Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids
Cell Transplant
2004
13(4):463-73
PubMed ID: 15468688
DOI: 10.3727/000000004783983882
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
DOI: 10.1016/j.bcp.2003.11.002
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2645
Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi
Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).
Int J Food Microbiol
2003
82:255-64
PubMed ID: 12593928
DOI: 10.1016/s0168-1605(02)00311-2
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3042
Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo
An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.
Biochim Biophys Acta
2003
1612:186-94
PubMed ID: 12787937
DOI: 10.1016/s0005-2736(03)00130-5
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3791
Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Pharm Res
2003
20(2):324-7
PubMed ID: 12636175
DOI: 10.1023/a:1022251910820
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3792
Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.
Growth promoting effect of thioredoxin on intestinal epithelial cells.
Dig Dis Sci
2003
48(2):379-85
PubMed ID: 12643619
DOI: 10.1023/a:1021952132241
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
DOI: 10.1007/s10047-003-0238-4
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3796
Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.
Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.
Int J Cancer
2003
107(1):53-9
PubMed ID: 12925956
DOI: 10.1002/ijc.11348
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2734
Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:885-90
PubMed ID: 12132663
DOI: 10.1248/bpb.25.885
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2629
Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji
Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.
Biochem Biophys Res Commun
2002
296:625-30
PubMed ID: 12176027
DOI: 10.1016/s0006-291x(02)00853-7
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2633
Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:1345-50
PubMed ID: 12392092
DOI: 10.1248/bpb.25.1345
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3750
Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.
Microbiol Immunol
2002
46(4):293-7
PubMed ID: 12061632
DOI: 10.1111/j.1348-0421.2002.tb02698.x
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3779
Yamauchi K, Komatsu T, Kulkarni AD, Ohmori Y, Minami H, Ushiyama Y, Nakayama M, Yamamoto S.
Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis.
Nutrition
2002
18(4):329-33
PubMed ID: 11934546
DOI: 10.1016/s0899-9007(01)00788-2
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3781
Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ.
Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells.
Biol Pharm Bull
2002
25(3):393-6
PubMed ID: 11913542
DOI: 10.1248/bpb.25.393
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3783
Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.
Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.
J Gastroenterol
2002
37(11):896-904
PubMed ID: 12483244
DOI: 10.1007/s005350200151
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16630
Nakamura T, Sakaeda T, Ohmoto N, Tamura T, Aoyama N, Shirakawa T, Kamigaki T, Nakamura T, Kim KI, Kim SR, Kuroda Y, Matsuo M, Kasuga M, Okumura K.
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas
Drug Metab Dispos
2002
30(1):4-6
PubMed ID: 11744604
DOI: 10.1124/dmd.30.1.4
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2554
Tamura, H., and Matsui, M.
Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
J Health Science
2001
47:468-472
DOI: 10.1248/jhs.47.468
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2544
Todoriki K, Mukai T, Sato S, Toba T
Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.
J Appl Microbiol
2001
91:154-9
PubMed ID: 11442725
DOI: 10.1046/j.1365-2672.2001.01371.x
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2553
Isozaki T, Tamura H
Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2001
24:1076-8
PubMed ID: 11558573
DOI: 10.1248/bpb.24.1076
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2550
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F
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