利用者成果(英) |
20031
Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin.
Biol Pharm Bull
2021
44(2):275-278
PubMed ID: 33518681
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13512
Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I.
Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase
mBio
2021
12(1):e01974-20
PubMed ID: 33563838
|
13556
Zhu Q, Komori H, Imamura R, Tamai I.
A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT
J Pharm Sci
2021
110(3):1392-1400
PubMed ID: 33278408
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20064
Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S.
Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.
Eur J Pharmacol
2021
898:173957
PubMed ID: 33662352
|
20066
Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y.
Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
Lipids Health Dis
2021
20(1):24
PubMed ID: 33648494
|
20080
Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T.
Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.
Int J Environ Res Public Health
2021
18(4)
PubMed ID: 33671655
|
13449
Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi
Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph
BMC
2020/1/1
|
11981
Kawahara T, Fujii K, Nakajima K, Fujii R, Inagaki S, Hara K, Yasui H.
Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells.
Planta Med.
2020
PubMed ID: 31896136
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12099
Meparambu Prabhakaran D, Ramamurthy T, Thomas S.
Genetic and virulence characterisation of Vibrio parahaemolyticus isolated from Indian coast.
BMC Microbiol.
2020
PubMed ID: 32293257
|
12276
Michihito Sasaki, Kentaro Uemura, Akihiko Sato, Shinsuke Toba, Takao Sanaki, Katsumi Maenaka, William W. Hall, Yasuko Orba, Hirofumi Sawa
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
bioRxiv
2020
August 28
|
12864
Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M.
Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy
Biol Trace Elem Res
2020
Nov 24
PubMed ID: 33236292
|
13047
Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N.
Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.
Bioorg Med Chem
2020
PubMed ID: 32616184
|
13091
Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.
Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
Carbohydr Polym
2020
PubMed ID: 32829826
|
13136
Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S.
10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.
Biol Pharm Bull
2020
PubMed ID: 32741940
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13162
Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.
Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.
J Oleo Sci
2020
PubMed ID: 32788522
|
13201
Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y.
Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.
Int J Oncol
2020
PubMed ID: 32901840
|
13211
Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.
Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.
Biochem Biophys Rep
2020
PubMed ID: 32964147
|
13234
Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.
Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
Biochem Biophys Res Commun
2020
PubMed ID: 32977947
|
13252
Yamashiro T, Yasujima T, Said HM, Yuasa H.
pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.
J Biol Chem
2020
PubMed ID: 33008889
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13289
Abe H, Koyama K, Koseki S.
Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.
Appl Environ Microbiol
2020
PubMed ID: 33067190
|
13316
Nagata Y, Yamamoto T, Kadowaki M.
Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.
J Nutr Sci Vitaminol (Tokyo)
2020
PubMed ID: 33132350
|
13517
Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M.
Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route
J Membr Biol
2020
253(3):221-228
PubMed ID: 32328687
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13550
Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T.
Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice
Cancer Sci
2020
111(4):1193-1202
PubMed ID: 31997435
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13574
Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M.
Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro
J Oleo Sci
2020
69(7):751-757
PubMed ID: 32612025
|
13620
Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.
Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats
Front Pharmacol
2020
11:1277
PubMed ID: 32922296
|
13623
BaoruiLi et al
Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1
Journal of Functional Foods
2020
75:104273
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13646
Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M.
Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids
Eur J Pharm Sci
2020
142:10514
PubMed ID: 31730802
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13840
Nakajima T, Sasaki K, Yamamori A, Sakurai K, Miyata K, Watanabe T, Matsunaga YT.
A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays
Biomater Sci
2020
8(20):5615-5627
PubMed ID: 32945306
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11283
Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N.
NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.
FASEB J.
2019
PubMed ID: 30399323
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11320
Hayashi I, Kanda S, Lamaningao P, Mishima N, Nishiyama T.
Shared expression of mucin12 in Ascaris lumbricoides and the human small intestine.
Mol. Biochem. Parasitol.
2019
PubMed ID: 30481538
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11386
Uchiyama H, Wada Y, Hatanaka Y, Hirata Y, Taniguchi M, Kadota K, Tozuka Y.
Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.
J Pharm Sci
2019
PubMed ID: 30653971
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11426
Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.
Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
Biochem. Biophys. Res. Commun.
2019
PubMed ID: 30739789
|
11487
Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N.
A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing.
Sci Rep
2019
PubMed ID: 30894579
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11641
Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.
Biochim Biophys Acta Mol Cell Biol Lipids
2019
PubMed ID: 31351225
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11702
Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki
Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose
Natural Product Communications
2019
|
11781
Tachibana K, Kondoh M.
A Method to Prepare Claudin-Modulating Recombinant Proteins.
Methods Mol. Biol.
2019
PubMed ID: 31471875
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11784
Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H.
α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation.
J. Cell. Biochem.
2019
PubMed ID: 31478242
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11825
Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.
Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.
Lipids
2019
PubMed ID: 31574565
|
11871
Numata T, Sato-Numata K, Okada Y.
Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.
Sci Rep
2019
PubMed ID: 31664151
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6882
Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.
Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.
Cancer Sci
2019
110(12):3708-3717
PubMed ID: 31648389
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6921
Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.
Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.
Nutr Res
2019
72:92-104
PubMed ID: 31767206
|
6940
Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.
Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.
Pharm Res
2019
37(1):13
PubMed ID: 31873817
|
6942
Mahmoud Abdel-Hamid et al
The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage
International Dairy Journal
2019
91:1-8
|
6966
Matsuzaki T, Nakamura M, Nogita T, Sato A.
Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.
Biol Pharm Bull
2019
42(6):989-995
PubMed ID: 31155596
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9418
Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome
Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha
iosci Microbiota Food Health
2019
38(1):11-22
PubMed ID: 30705798
|
9414
Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2
CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin
Mol Cell Biol
2019
39(16):e00073-19
PubMed ID: 31160493
|
10420
Sanae Yoshimoto, Keiko Okada, Osamu Hayashi
Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier
Functional Foods in Health and Disease
2019
9(7):466-483
|
10587
Selma Etteieb Jamila Tarhouni Hiroko Isoda
Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures
Water and Environment Journal
2019
33:4-13
|
10588
Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients
Journal of Functional Foods
2019
55:352-361
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11913
Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.
Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.
Cancers (Basel)
2019
PubMed ID: 31769426
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12013
Matsumoto A, Watanabe C, Murakami M.
Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.
Drug Discov Ther
2019
PubMed ID: 31956233
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12437
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
PubMed ID: 30875389
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12517
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
2019
33(2):189-195
PubMed ID: 29457741
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10543
Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.
Biochim. Biophys. Acta
2018
1860:428-433
PubMed ID: 28988777
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10556
Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Toxicol In Vitro
2018
46:284-293
PubMed ID: 29054700
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10580
Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.
Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.
Glycobiology
2018
28:21-31
PubMed ID: 29069492
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10656
Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.
Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
Arch. Biochem. Biophys.
2018
638:58-65
PubMed ID: 29242061
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10665
Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene
2018
37:1205-1219
PubMed ID: 29242607
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10681
Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Exp. Anim.
2018
67:201-218
PubMed ID: 29276215
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10794
Numata T, Sato-Numata K, Okada Y, Inoue R.
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.
J Nat Med
2018
72:694-705
PubMed ID: 29569221
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11102
Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.
A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.
Sci Rep
2018
8(1):9008
PubMed ID: 29899364
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11130
Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.
Probiotics in human gut microbiota can degrade host glycosaminoglycans.
Sci Rep
2018
8(1):10674
PubMed ID: 30006634
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11260
Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.
Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.
Mol. Pharm.
2018
PubMed ID: 30359033
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4174
Sakuta Y, Takehara I, Tsunoda KI, Sato K.
Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.
Anal Sci
2018
PubMed ID: 29806615
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4472
Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
Inflamm. Res.
2018
67(11-12):975-984
PubMed ID: 30317465
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4473
Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.
Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo.
Biol. Pharm. Bull.
2018
41(2):190-197
PubMed ID: 29386479
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9492
Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown
TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma
Oncotarget
2018
9(26):18480-18493
PubMed ID: 29719619
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9991
Kota Noda, Eisuke Kato, Jun Kawabata
Search for Compounds Suppressing Intestinal α-Glucosidase Expression in Caco-2 Cells
Proceedings of the International Conference on Innovation, Entrepreneurship and Technology
2018
2:90-95
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9909
Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.
Role of CXC chemokine receptor type 4 as a lactoferrin receptor.
Biochem. Cell Biol.
2017
95:57-63
PubMed ID: 28075616
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10056
Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.
miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.
BMC Cancer
2017
17:33
PubMed ID: 28061765
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10091
Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.
Biochem. Biophys. Res. Commun.
2017
484:543-549
PubMed ID: 28130106
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10167
Takahashi K, Suzuki N, Ogra Y.
Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.
Int J Mol Sci
2017
18:
PubMed ID: 28245633
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10214
Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.
Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.
Eur. J. Pharmacol.
2017
804:46-51
PubMed ID: 28327343
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10227
Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.
Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.
J. Food Sci.
2017
82:1224-1230
PubMed ID: 28346686
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10247
Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y.
Carnosine activates the CREB pathway in Caco-2 cells.
Cytotechnology
2017
69:523-527
PubMed ID: 28374107
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10319
Nakayama T, Funakoshi-Tago M, Tamura H.
Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.
Oncol Lett
2017
14:1109-1114
PubMed ID: 28693281
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10325
Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.
Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.
Toxicol. Lett.
2017
277:18-23
PubMed ID: 28552774
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10474
Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.
Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Biochem. Pharmacol.
2017
145:192-201
PubMed ID: 28843775
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10552
Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.
Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.
Am. J. Chin. Med.
2017
45:1497-1511
PubMed ID: 29025293
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10635
Yamashita S, Seino T, Aida K, Kinoshita M.
Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.
J Oleo Sci
2017
66:1337-1342
PubMed ID: 29199207
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10976
Effect of luteolin on the expression of intestinal cholesterol transporters
Journal of Functional Foods
2017
36:274-279
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10979
1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis
Nutrition Research
2017
46, 59-67
PubMed ID: 28931466
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10996
Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells
Journal of Functional Foods
2017
39, 91-95
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10999
Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity
Food Science and Technology Research
2017
23, 725-732
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4194
Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.
A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.
Lab Chip
2017
PubMed ID: 29184959
|
10008
Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto
Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers
J Clin Biochem Nutr
2017
60(2):81-85
PubMed ID: 28366985
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10019
Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga
Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes
Biochem Biophys Res Commun
2017
486(1):143-148
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Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita
Design and fabrication of devices for investigating cell-sheet stretch
BioChip Journal
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11:173–179
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Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells
Int J Oncol
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Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity
J Gastroenterol Hepatol
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32(11):1839-1845
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Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito
Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications
Front Physiol
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Kaku Y, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T.
HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.
Anticancer Res.
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Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T.
Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.
Int. J. Oncol.
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Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.
Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.
Sci Rep
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Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K.
Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.
J Nat Med
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Jdir H, Khemakham B, Najjaa H, Chakroun M, Jridi M, Ben Arfa A, Ben Ali Y, Zouari N.
Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex.
Pharm Biol
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Kaze N, Watanabe Y, Sato H, Murota K, Kotaniguchi M, Yamamoto H, Inui H, Kitamura S.
Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters.
Lipids
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51:913-22
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Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T.
Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
J. Biol. Chem.
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Kimura O, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y, Endo T.
Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers.
J. Pharm. Pharmacol.
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Kudo M, Katayoshi T, Kobayashi-Nakamura K, Akagawa M, Tsuji-Naito K.
H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.
Biochem. Biophys. Res. Commun.
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Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y.
Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.
Oxid Med Cell Longev
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Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water
Water, Air, & Soil Pollution
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The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.
Int J Mol Sci
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17(12). pii: E1979
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Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama
Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis
PLoS One
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Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa
The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro
J Vet Med Sci
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78(4):627-32
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Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone
Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells
Nutr Res .
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Katsuya Narumi, Masaki Kobayashi, Ayuko Kondo, Ayako Furugen, Takehiro Yamada, Natsuko Takahashi, Ken Iseki
Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen
Biopharm Drug Dispos
2016
7(8):447-455
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Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara
An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1
Biol Pharm Bull .
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Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu
New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Phytochemistry Letters
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Iwazaki A, Takahashi N, Miyake R, Hiroshima Y, Abe M, Yasui A, Imai K.
Effect of dietary fibers on losartan uptake and transport in Caco-2 cells
Biopharm Drug Dispos
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37(4):212-9
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Shimizu T, Ichimura K, Noda M.
The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.
Infect. Immun.
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Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T.
The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus.
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Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K.
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Biochem. Pharmacol.
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Kaku Y, Tsuchiya A, Kanno T, Nishizaki T.
Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.
Pharmacology
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Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A.
Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.
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Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S.
Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum.
Physiol Rep
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Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA
Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.
Deep Ocean Water Research
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Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura
Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice
Exp Cell Res
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Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto
Jpn J Pharm Health Care Sci
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41(4): 236―243
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Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
Sustained Inhibition of Proton-Coupled Folate Transporter by Myricetin
Drug Metab Pharmacokinet
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Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato
Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life
Eur J Pharm Sci
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67:136-143
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Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki
Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy
J Control Release
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Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami
Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption
J Nutr Sci Vitaminol (Tokyo)
2015
61(6):449-54
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Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab
Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines
Energy Procedia
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74:878 – 885
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Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe
Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity
J Ethnopharmacol
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161:147-55
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Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano
The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells
J Cell Mol Med
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19(7):1569-81
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Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida
Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer
Mol Clin Oncol
2015
3(5):1080-1084
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Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota
Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas
Oncology
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88(5):309-19
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Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa
Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation
J Biol Chem
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Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham
Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats
Nanomedicine
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11(5):1227-36
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Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi
Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats
PLoS One
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9(5):e97901
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Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo
Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells
Food Chem
2014
154:145-50
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Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo
Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells
Pestic Biochem Physiol .
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Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki
Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells
Biol Pharm Bull
2014
37(3):490-2
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Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi
Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO)
Life Sci .
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107(1-2):14-20
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Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo
Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters
Biol Pharm Bull .
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37(9):1475-9
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Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani
Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption
Drug Metab Pharmacokinet
2014
29(5):414-8
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Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura
Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation
FEBS Lett .
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Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto
Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases
Cancer Chemother Pharmacol
2014
74(5):1023-8
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Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto
Induction of AhR-mediated Gene Transcription by Coffee
PLoS One
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9(7):e102152
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10225
Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin
Drug Metab Pharmacokinet
2014
29(4):312-6
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Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki
Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion
J Pharm Pharm Sci
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17(2):266-76
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Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto
Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin
Biopharm Drug Dispos
2014
35(6):321-9
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Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi
Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures
Tumour Biol
2014
35(12):12689-93
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T Nakayama, K Ezoe
Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O
Curr Microbiol .
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69(5):690-8
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Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki
Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke
Sci Technol Adv Mater
2014
15(3):035002
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Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation
Immunol Cell Biol
2014
92(7):624-30
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10254
Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi
Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells
J Clin Biochem Nutr
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55(3):162-7
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Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure
Electric Stimulus Opens Intercellular Spaces in Skin
J Biol Chem
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24;289(4):2450-6
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Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane
Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D
FEMS Microbiol Lett
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Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.
Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.
Biochim Biophys Acta
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Isshiki M, Ohta H, Tamura H.
Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells
Biol Pharm Bull
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Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H.
Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells
J Pharm Pharmacol
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Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K.
An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells
3 Biotech
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Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J.
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
World J Gastroenterol
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Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H.
Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes
Biol Pharm Bull
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Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.
Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
J Biol Chem
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Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.
INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors
Biochem Biophys Res Commun
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Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J.
Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery
Eur J Pharm Sci
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Kamishikiryo J, Matsumura R, Takamori T, Sugihara N.
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Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.
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Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N.
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Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K.
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Int Immunopharmacol
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Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.
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Int J Oncol
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Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto
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J Biosci Bioeng
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Matsuo Y, Miyoshi Y, Okada S, Satoh E.
Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri
Biosci Microbiota Food Health
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31(4):93-102
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Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M.
CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer
Eur J Cancer
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Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K.
Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins
Acta Med Okayama
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66(3):253-61
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Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K.
Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein
J Pharm Pharm Sci
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Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.
Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine
J Sci Food Agric
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Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M.
Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients
Ann Surg Oncol
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Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K.
Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP
J Pharm Pharm Sci
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15(2):295-304
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Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO
Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu”
Food Science and Technology Research
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18:825-834
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Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N.
Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate
J Food Sci
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Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.
A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers
Biol Pharm Bull
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Chaisowwong W, Kusumoto A, Hashimoto M, Harada T, Maklon K, Kawamoto K.
Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat
J Vet Med Sci
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Kimura O, Tsukagoshi K, Hayasaka M, Endo T.
Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.
Basic Clin. Pharmacol. Toxicol.
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Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.
Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.
Biol. Pharm. Bull.
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Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M.
Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum.
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Coffee induces breast cancer resistance protein expression in Caco-2 cells.
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Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M.
Isolation and characterization of a novel short peptide associated with Crohn's disease.
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Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.
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Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y.
Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.
Biopharm Drug Dispos
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Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.
Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
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Tsuruta H, Yagishita T, Shimizu M, Tamura H.
Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2.
Toxicol In Vitro
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25:500-4
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Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.
Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.
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Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai
Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis
Infect Immun
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Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda
Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli
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Takeda S, Yamasaki K, Takeshita M, Kikuchi Y, Tsend-Ayush C, Dashnyam B, Ahhmed AM, Kawahara S, Muguruma M.
The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products
Anim Sci J
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Okumura S, Saitoh H, Ishikawa T, Inouye K, Mizuki E.
Mode of action of parasporin-4, a cytocidal protein from Bacillus thuringiensis
Biochim Biophys Acta
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Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M.
Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy.
JPEN J Parenter Enteral Nutr
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Wang C, Ho PC, Lim LY.
Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells.
Int J Pharm
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400:201-10
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Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.
Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition.
Cell. Physiol. Biochem.
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26:125-34
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Watanabe K, Kamata K, Sato J, Takahashi T.
Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption.
J Ethnopharmacol
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132:193-9
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Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.
Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.
Br. J. Cancer
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103:517-23
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Takahashi T, Kaku T, Sato T, Watanabe K, Sato J.
Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2.
J Nat Med
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64:55-62
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Shirou Itagaki et al.
Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2
Food Chemistry
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120(2):552-555
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Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.
Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer
Cell Physiol Biochem
2010
54(8):1182-91
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Nagamatsu Y, Okamura S, Saitou H, Akao T, Mizuki E.
Three Cry toxins in two types from Bacillus thuringiensis strain M019 preferentially kill human hepatocyte cancer and uterus cervix cancer cells
Biosci Biotechnol Biochem
2010
74(3):494-8
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Mari Takaai, Jumpei Sakata, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto
Mechanisms for Transport of Methotrexate across Apical and Basolateral Membranes in Human Intestinal Epithelial Caco-2 Cells
ryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
2010
36:63
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Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y, Nishimura Y.
The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy
Int J Cancer
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126(9):2153-63
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Narita K, Kawate T, Kakinuma N, Takeda S.
Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium.
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Yamanashi Y, Takada T, Suzuki H.
In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.
Pharmacogenet. Genomics
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19:884-92
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Yoshimura S, Kawano K, Matsumura R, Sugihara N, Furuno K.
Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.
J. Biomed. Biotechnol.
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Kimura O, Tsukagoshi K, Endo T.
Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters.
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Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T.
Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors.
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Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.
Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.
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Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.
FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.
Biol Pharm Bull
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32(7):1148-54
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Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
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Sugawara T, Yamashita K, Asai A, Nagao A, Shiraishi T, Imai I, Hirata T.
Esterification of xanthophylls by human intestinal Caco-2 cells
Arch Biochem Biophys
2009
483(2):205-12
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Ishida K, Taguchi M, Akao T, Hashimoto Y.
Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells
Biol Pharm Bull
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32(3):513-6
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Kazuhiro Yamamoto, Hideki Hakamata, Akira Yamaguchi, Fumiyo Kusu
An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers
Anal Bioanal Chem
2009
395(2):533-8
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Fukumori S, Masago M, Ishida K, Kayano Y, Taguchi M, Hashimoto Y.
Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells
Biopharm Drug Dispos
2009
30(8):448-56
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Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y.
Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma
Biochem Biophys Res Commun
2009
383(4):480-4
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Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.
Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.
Biosci. Biotechnol. Biochem.
2008
72:3148-57
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Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.
Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.
J. Agric. Food Chem.
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56:10515-20
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Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.
Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.
Biol. Pharm. Bull.
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31:949-54
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Ayako Saruwatari, Shigeaki Okamura, Yoko Nakajima, Yuji Narukawa, Tadahiro Takeda, Hiroomi Tamura
Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells
J Med Food
2008
11(4):623-8
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Saruwatari A, Isshiki M, Tamura H.
Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells
iol Pharm Bull
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31(11):2131-6
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Seki T, Harada S, Hosoya O, Morimoto K, Juni K.
Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes
Biol Pharm Bull
2008
31(1):163-6
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Kimura O, Tsukagoshi K, Endo T.
Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter
Toxicol Appl Pharmacol
2008
227(3):325-30
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Kimura H, Yamamoto T, Sakai H, Sakai Y, Fujii T.
An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models
Lab Chip
2008
8(5):741-6
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Han Y, Chin Tan TM, Lim LY.
In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression
Toxicol Appl Pharmacol
2008
230(3):283-9
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Fukumori S, Murata T, Takaai M, Tahara K, Taguchi M, Hashimoto Y.
The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells
Drug Metab Pharmacokinet
2008
23(5):373-8
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Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.
Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia
J Lipid Res
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Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y.
The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption
Cell Microbiol
2008
10(2):355-64
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Takaai M, Morishita H, Ishida K, Taguchi M, Hashimoto Y.
Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells
Eur J Pharmacol
2008
601(1-3):61-5
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Kadowaki M, Sugihara N, Tagashira T, Terao K, Furuno K.
Presence or absence of a gallate moiety on catechins affects their cellular transport
J Pharm Pharmacol
2008
60(9):1189-95
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Shah AK, Kinoshita M, Kurihara H, Ohnishi M, Takahashi K.
Glycosylceramides obtain from the starfish Asterias amurensis Lütken
J Oleo Sci
2008
57(9):477-84
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Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.
Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity
Biol Pharm Bull
2008
31(10):1933-7
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Chono S, Takeda E, Seki T, Morimoto K.
Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin
Int J Pharm
2008
347(1-2):71-8
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Katsube T, Tsuji H, Onoda M.
Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.
Biochim. Biophys. Acta
2007
1773:794-803
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Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.
Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.
Br. J. Pharmacol.
2007
150:209-19
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Ito T, Maki N, Hazeki O, Sasaki K, Nekooki M.
Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines.
Cell Biol Int
2007
31(12):1518-24
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Arimochi J, Ohashi-Kobayashi A, Maeda M.
Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.
Biol Pharm Bull
2007
30(4):648-54
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Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R.
Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.
Biosci Biotechnol Biochem
2007
71(8):1886-95
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Y-C Jung, E Mizuki, T Akao, J-C Côté
Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells
J Appl Microbiol
2007
103 (1), 65-79
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Hitoshi HORIE, Yuichi FUJII, Kouji KATABAMI, Masanori IWAMA, Akira YAMADA
Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype
Journal of Traditional Medicines
2007
24: 156-163
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Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, Tomohiro Hosoi
Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid
Biosci Biotechnol Biochem
2007
71(10):2428-34
PubMed ID: 17928716
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12815
Satoko GUNJI, Joko SANTOSO, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide
Food Science and Technology Research
2007
13:275-279
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Oda M, Fujimoto K, Kobayashi M, Saitoh H.
Bacampicillin uptake is shared with thiamine in Caco-2 cells
Biol Pharm Bull
2007
30(7):1344-9
PubMed ID: 17603179
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Sugihara N, Toyama K, Okamoto T, Kadowaki M, Terao K, Furuno K.
Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach
Toxicol In Vitro
2007
21(5):827-34
PubMed ID: 17408918
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Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers
Biol Pharm Bull . 2007 Nov;30(11):2167-72
2007
30(11):2167-72
PubMed ID: 17978494
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Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M.
TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation
World J Gastroenterol
2007
13(19):2717-21
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Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y.
Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2007
30(10):1930-3
PubMed ID: 17917264
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Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.
Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro
Am J Physiol Gastrointest Liver Physiol
2007
292(3):G923-9
PubMed ID: 17170030
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12807
Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E.
Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells
J Biol Chem
2007
282(10):7742-52
PubMed ID: 17204466
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Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki
Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats
Asian-Australasian Journal of Animal Sciences
2007
20(7): 1120-1126
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Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T.
Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport
J Pharm Pharmacol
2007
59(10):1383-7
PubMed ID: 17910813
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Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro
In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.
Drug Metab Dispos
2006
34:369-74
PubMed ID: 16326817
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Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao
Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.
J Pharm Sci
2006
95:552-60
PubMed ID: 16419049
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8890
Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.
Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.
Biol. Pharm. Bull.
2006
29:535-8
PubMed ID: 16508161
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12816
Han Y, Tan TM, Lim LY.
Effects of capsaicin on P-gp function and expression in Caco-2 cells
Biochem Pharmacol
2006
71(12):1727-34
PubMed ID: 16674925
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12817
Watanabe K, Jinriki T, Sato J.
Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2
Biol Pharm Bull
2006
29(1):90-5
PubMed ID: 16394517
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12818
Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T.
Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells
Biosci Biotechnol Biochem
2006
70(12):2906-12
PubMed ID: 17151482
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12819
Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K.
Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers
J Pharm Sci
2006
95(6):1393-401
PubMed ID: 16625653
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12820
M Gueimonde et al
Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli
Food Research International
2006
39:467-471
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12821
Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.
Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer
Toxicology
2006
223(1-2):156-65
PubMed ID: 16647797
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12822
Ishida K, Takaai M, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2006
29(3):522-6
PubMed ID: 16508158
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12823
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Food Science and Technology Research
2006
12:290-294
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12824
Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
J Gastroenterol
2006
2006 Feb;41(2):140-50
PubMed ID: 16568373
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12825
Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.
Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
Hepatol Res
2006
35(3):152-62
PubMed ID: 16707273
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12826
Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.
Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli
Protein Expr Purif
2006
47(1):144-51
PubMed ID: 16307894
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12827
Makoto KIMURA, Kuninaga DANNO, Hisako YASUI
Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk
Bioscience and Microflora
2006
25:147-155
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12828
Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.
Determination of p-glycoprotein ATPase activity using luciferase
Biol Pharm Bull
2006
29(3):560-4
PubMed ID: 16508168
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
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3026
Aiba T, Susa M, Fukumori S, Hashimoto Y
The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180
Drug Metab Pharmacokinet
2005
20:268-274
PubMed ID: 16141606
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3025
Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya
Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.
Biol Pharm Bull
2005
28:114-9
PubMed ID: 15635174
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3072
Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru
Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.
Biosci Biotechnol Biochem
2005
69:202-5
PubMed ID: 15665486
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3300
Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.
Biol Pharm Bull
2005
28:527-30
PubMed ID: 15744083
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3155
Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu
Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.
Int J Vitam Nutr Res
2005
75:39-46
PubMed ID: 15830920
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3164
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Biochemistry
2005
44:6343-9
PubMed ID: 15835923
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3270
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
Hepatol. Res.
2005
33:198-205
PubMed ID: 16198622
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9134
Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.
CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS
Chiang Mai Med Bull
2005
44:21-28
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9048
Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye
Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines
J Agric Food Chem
2005
53 (16), 6313-8
PubMed ID: 16076112
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12832
Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2
Food Science and Technology Research
2005
11:202-206
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12833
Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.
The effects of coffee on conjugation reactions in human colon carcinoma cells
Biol Pharm Bull
2005
28(2):271-4
PubMed ID: 15684482
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12835
Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.
Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
Biochim Biophys Acta
2005
1732(1-3):43-52
PubMed ID: 16380173
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2720
Saegusa S, Totsuka M, Kaminogawa S, Hosoi T
Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.
FEMS Immunol Med Microbiol
2004
41:227-35
PubMed ID: 15196572
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2736
Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi
Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.
Eur J Pharm Sci
2004
21:87-95
PubMed ID: 14706815
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
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2735
Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi
Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.
Biol Pharm Bull
2004
27:559-63
PubMed ID: 15056866
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3199
Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji
Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.
Am J Physiol Cell Physiol
2004
287:C1404-11
PubMed ID: 15229109
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
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3094
Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Cancer Res
2004
64:6410-5
PubMed ID: 15374948
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2708
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.
Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.
J. Exp. Clin. Cancer Res.
2004
23:69-75
PubMed ID: 15149153
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3066
Aida K. et al.
Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.
J Oleo Sci.
2004
53:503-510
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4723
Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.
Oncol Res
2004
14(9):407-14
PubMed ID: 15490972
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12839
Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.
Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells
Biosci Biotechnol Biochem
2004
68(12):2541-6
PubMed ID: 15618625
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12840
Shigeaki Okamura, Hiro-omi Tamura
Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2
Journal of Health Science
2004
50:189-192
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
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12843
Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.
Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids
Cell Transplant
2004
13(4):463-73
PubMed ID: 15468688
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
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2645
Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi
Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).
Int J Food Microbiol
2003
82:255-64
PubMed ID: 12593928
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3042
Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo
An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.
Biochim Biophys Acta
2003
1612:186-94
PubMed ID: 12787937
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3791
Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Pharm Res
2003
20(2):324-7
PubMed ID: 12636175
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3792
Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.
Growth promoting effect of thioredoxin on intestinal epithelial cells.
Dig Dis Sci
2003
48(2):379-85
PubMed ID: 12643619
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
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3796
Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.
Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.
Int J Cancer
2003
107(1):53-9
PubMed ID: 12925956
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2734
Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:885-90
PubMed ID: 12132663
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2629
Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji
Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.
Biochem Biophys Res Commun
2002
296:625-30
PubMed ID: 12176027
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2633
Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:1345-50
PubMed ID: 12392092
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3750
Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.
Microbiol Immunol
2002
46(4):293-7
PubMed ID: 12061632
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3779
Yamauchi K, Komatsu T, Kulkarni AD, Ohmori Y, Minami H, Ushiyama Y, Nakayama M, Yamamoto S.
Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis.
Nutrition
2002
18(4):329-33
PubMed ID: 11934546
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3781
Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ.
Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells.
Biol Pharm Bull
2002
25(3):393-6
PubMed ID: 11913542
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3783
Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.
Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.
J Gastroenterol
2002
37(11):896-904
PubMed ID: 12483244
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2554
Tamura, H., and Matsui, M.
Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
J Health Science
2001
47:468-472
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2544
Todoriki K, Mukai T, Sato S, Toba T
Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.
J Appl Microbiol
2001
91:154-9
PubMed ID: 11442725
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2553
Isozaki T, Tamura H
Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2001
24:1076-8
PubMed ID: 11558573
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2550
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F
Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.
Biol Pharm Bull
2001
24:1258-62
PubMed ID: 11725959
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3768
Takeuchi K, Mizuno M, Uesu T, Nasu J, Kawada M, Hori S, Okada H, Endo Y, Fujita T, Tsuji T.
Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway.
J Lab Clin Med
2001
138(3):186-92
PubMed ID: 11528371
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3771
Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.
DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Cancer Genet Cytogenet
2001
126(1):34-8
PubMed ID: 11343776
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3772
Ijichi H, Ikenoue T, Kato N, Mitsuno Y, Togo G, Kato J, Kanai F, Shiratori Y, Omata M.
Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.
Biochem Biophys Res Commun
2001
289(2):350-7
PubMed ID: 11716479
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3774
Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S.
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.
Biochem Biophys Res Commun
2001
280(5):1216-23
PubMed ID: 11162657
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2551
Tamura H, Matsui M
Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:695-9
PubMed ID: 10864017
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2552
Satoh T, Matsui M, Tamura H
Sulfotransferases in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:810-4
PubMed ID: 10919357
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3780
Endo T, Kimura O, Saitoh H, Sakata M.
Secretory transport of cadmium through intestinal brush border membrane via H(+)-antiport.
Toxicology
2000
150(1-3):129-36
PubMed ID: 10996669
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3761
Nakayama A, Saitoh H, Oda M, Takada M, Aungst BJ.
Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system.
Eur J Pharm Sci
2000
11(4):317-24
PubMed ID: 11033075
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3763
Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.
Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.
Biochem Biophys Res Commun
2000
19;267(2):658-62
PubMed ID: 10631118
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3758
Miyata R, Iwabuchi K, Watanabe S, Sato N, Nagaoka I.
Short exposure of intestinal epithelial cells to TNF-alpha and histamine induces Mac-1-mediated neutrophil adhesion independent of protein synthesis.
J Leukoc Biol
1999
66(3):437-46
PubMed ID: 10496314
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2273
Kanda T, Foucand L, Nakamura Y, Niot I, Besnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H
Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells
Biochem J
1998
330:261-265
PubMed ID: 9461519
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12856
Tsuji S, Kawano S, Sawaoka H, Takei Y, Kobayashi I, Nagano K, Fusamoto H, Kamada T.
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines
Prostaglandins Leukot Essent Fatty Acids
1996
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PubMed ID: 8931116
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