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Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies.
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22980
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Biofabrication
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J Agric Food Chem
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EBioMedicine
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FEMS Microbiol Lett
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Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease.
World J Gastroenterol
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Biosens Bioelectron
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Food Production, Processing and Nutrition
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Int Immunopharmacol
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Specific inhibitory effects of exogenous d-Aspartate on the proliferation of intestinal epithelial cells.
Biochem Biophys Res Commun
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Mol Cell Biochem
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Therapeutic Effect of Proteinase-Activated Receptor-1 Antagonist on Colitis-Associated Carcinogenesis
Cell Mol Gastroenterol Hepatol
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Biomedicines
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Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease
Cells
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22323
Yusuke Takizawa, Yuka Nagai, Miho Ishii, Satoshi Yasunaga, Yuki Aizawa, Takahito Furuya, Takuro Kurita, Junichi Masuda, Takanori Nakajima
Comparison of a brand-name drug and its generic drugs - Impact of anti-human immunodeficiency virus drug exposure on the intestinal epithelial barrier
Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector
2024
20:77-85
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22402
Y. Takizawa, A. Kato, A. Onsui, S. Kanatanai, A. Ishimura, T. Kurita, T. Nakajima
Impact of Glucagon-like Peptide-1 Receptor Agonists on Intestinal Epithelial Cell Barrier
European Pharmaceutical Journal
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Mubarek MM, Othman A, Abdelkarem FM, Shimizu K.
Isolation of two new cucurbitane-type triterpenoids from Kedrostis gijef
Nat Prod Res
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SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption
Elife
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Size-Dependent Internalization of Microplastics and Nanoplastics Using In Vitro Model of the Human Intestine-Contribution of Each Cell in the Tri-Culture Models
Nanomaterials (Basel)
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Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation
Nutrients
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5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells
Biochem Biophys Res Commun
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Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H.
Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells
Biosci Biotechnol Biochem
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17775
Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima
The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells
J. Excipients and Food Chem
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Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels
BMC Cancer
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23(1):356
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International Journal of Agricultural Technology
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Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT
Food Funct
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Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound
Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound
Molecules
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28(11):4549
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Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cells
Biosci Biotechnol Biochem
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87(8):839-849
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Yusuke Takizawa, Naruya Kunii, Takanori Nakajima
Comparison of pharmaceutical characteristics and membrane permeability of truvada combination tablets and its generic drugs
Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector
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Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome
Gut Liver
2023
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Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid
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Characterization of Lactococcus lactis 11/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic
Microorganisms
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Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation
Toxicol Mech Methods
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Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers
J Pharm Sci
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Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer
In Vivo
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p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells
PLoS One
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Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system
Drug Metab Pharmacokinet
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Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α.
Biochem Biophys Res Commun
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Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Biochim Biophys Acta Mol Cell Res
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Tsubaki M, Takeda T, Matsuda T, Kishimoto K, Takefuji H, Taniwaki Y, Ueda M, Hoshida T, Tanabe K, Nishida S.
Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy.
Cancer Cell Int
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Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols.
Mol Biol Rep
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Lyu M, Bai Y, Orihara K, Miyanaga K, Yamamoto N.
GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions.
Microorganisms
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Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E.
Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.
Biochem Biophys Res Commun
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672:72-80
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Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.
Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.
Ann Surg Oncol
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Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
J Gastroenterol
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Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells.
Carbohydr Res
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21419
Shibamoto A, Kaji K, Nishimura N, Kubo T, Iwai S, Tomooka F, Suzuki J, Tsuji Y, Fujinaga Y, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin.
J Nutr Biochem
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Kataoka M, Kitazawa M, Nakamura S, Koyama M, Yamamoto Y, Miyazaki S, Hondo N, Tanaka H, Soejima Y.
Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment.
Anticancer Res
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43(10):4341-4348
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21445
Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M.
Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.
Pharmaceutics
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15(9)
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21455
Hiranphinyophat S, Hiraoka T, Kobayashi M, Fujii S, Kishida A, Tanabe T, Kimura T, Yamamoto M.
Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies.
Langmuir
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PubMed ID: 37882450
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Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine.
Biol Pharm Bull
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Kiba Y, Tanikawa T, Hayashi T, Kamauchi H, Seki T, Suzuki R, Kitamura M.
Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains.
Biomed Pharmacother
2023
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Hayashi A, Sakamoto N, Kobayashi K, Murata T.
Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion
Front Immunol
2023
14:1276852
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Effects of Synbiotic Lacticaseibacillus paracasei, Bifidobacterium breve, and Prebiotics on the Growth Stimulation of Beneficial Gut Microbiota
Foods
2023
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Usui S, Zhu Q, Komori H, Iwamoto Y, Nishiuchi T, Shirasaka Y, Tamai I.
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα
Drug Metab Pharmacokinet
2023
52:100512
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Hashizume J, Sato K, Nakagawa H, Harasawa H, Honda T, Kodama Y.
Examination of the Effect of Proton Pump Inhibitors on the Anticancer Activity of Oxaliplatin
Cancer Diagn Progn
2022
2(6):620-626
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Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells
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Journal of Applied Pharmaceutical Science
2022
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Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, Yamaji R.
Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide
J Agric Food Chem
2022
70(49):15499-15508
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Tlili H, Arfa AB, Boubakri A, Hanen N, Neffati M, Doria E.
Biochemical Composition and Biological Activities of Various Population of Brassica tournefortii Growing Wild in Tunisia
Plants (Basel)
2022
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Ariumi Y.
Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection
J Virol
2022
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Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T.
Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system
Arch Toxicol
2022
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PubMed ID: 34654938
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Shinji S, Shichi Y, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Yonaga K, Iwai T, Takeda K, Ueda K, Kuriyama S, Miyasaka T, Ueda Y, Sasaki N, Takahashi K, Ohashi R, Ishiwata T, Arai T, Yoshida H.
A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor
J Nippon Med Sch
2022
89(4):368-376
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Naoki Murata, Saki Keitoku, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata
Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers
Natural Product Communications
2022
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Inada A, Sawao A, Takahashi K, Oshima T.
Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate
J Food Sci
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Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S.
PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells
Oncol Lett
2022
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Diao X, Yamada K, Shibata Y, Imada C.
Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide.
Mar Drugs
2022
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PubMed ID: 35200617
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20610
Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.
TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.
Biochem Biophys Rep
2022
30:101239
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Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A.
Indigo plant leaf extract inhibits the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2.
Exp Ther Med
2022
23(4):274
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Enomoto M, Kaji K, Nishimura N, Fujimoto Y, Murata K, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.
Dig Liver Dis
2022
PubMed ID: 35514019
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Takahashi Y, Abe H, Koayama K, Koseki S.
Modeling the invasion of human small intestinal epithelial-like cells by Salmonella enterica Typhimurium and Listeria monocytogenes using Bayesian inference.
Lett Appl Microbiol
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PubMed ID: 35575530
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16510
Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu
Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation
Toxicology Reports
2022
9:937-944
PubMed ID: 35875256
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20749
Takizawa Y, Nakamura R, Kurita T, Nakajima T.
Lactose hydrate can increase the transcellular permeability of β-naphthol in rat jejunum and ileum.
Mol Biol Rep
2022
PubMed ID: 35767107
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Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima
Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells
Scholars Academic Journal of Pharmacy
2022
11:60-66
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16738
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama
Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding
BPB Reports
2022
5:66-69
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Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.
Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles
J Biotechnol
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354:34-44
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Kawahara T, Shimizu I, Tanaka Y, Tobita K, Tomokiyo M, Watanabe I.
Lactobacillus crispatus Strain KT-11 S-Layer Protein Inhibits Rotavirus Infection
Front Microbiol
2022
13:783879
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Onuma S, Kinoshita S, Shimba S, Ozono K, Michigami T, Kawai M.
The lack of Bmal1, a core clock gene, in the intestine decreases glucose absorption in mice.
Endocrinology
2022
PubMed ID: 35904419
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Sakakibara Y, Kojima A, Asai Y, Nadai M, Katoh M.
Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid.
Biopharm Drug Dispos
2022
PubMed ID: 36000181
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20956
Satow R, Suzuki Y, Asada S, Ota S, Idogawa M, Kubota S, Ikeo N, Yoneda A, Fukami K.
Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells.
iScience
2022
25(12):105501
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Akino S, Yasujima T, Yamashiro T, Yuasa H.
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter.
Life Sci Alliance
2022
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Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima
The influence of 4-methylimidazole on the gastrointestinal epithelial cells
J. Excipients and Food Chem
2021
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Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M.
Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy
Biol Trace Elem Res
2021
199(9):3272-3286
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Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T.
BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
Nat Commun
2021
12(1):6767
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Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin.
Biol Pharm Bull
2021
44(2):275-278
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Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I.
Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase
mBio
2021
12(1):e01974-20
PubMed ID: 33563838
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Zhu Q, Komori H, Imamura R, Tamai I.
A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT
J Pharm Sci
2021
110(3):1392-1400
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Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S.
Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.
Eur J Pharmacol
2021
898:173957
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20066
Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y.
Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
Lipids Health Dis
2021
20(1):24
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Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T.
Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.
Int J Environ Res Public Health
2021
18(4)
PubMed ID: 33671655
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20149
Igarashi F, Nakagawa T, Shinohara Y, Tachibana T.
Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.
Pharm Res
2021
Pharm Res
PubMed ID: 34009624
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Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M.
An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement
PLoS One
2021
16(6):e0253066
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14782
Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A.
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Sci Rep
2021
11(1):5376
PubMed ID: 33686154
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Sasaki M, Uemura K, Sato A, Toba S, Sanaki T, Maenaka K, Hall WW, Orba Y, Sawa H.
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
PLoS Pathog
2021
17(1):e1009233
PubMed ID: 33476327
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20226
Chowdhury MMI, Tomii A, Ishii K, Tahara M, Hitsuda Y, Koto Y, Kurata K, Yuasa K, Nishimura K, Shimizu H.
TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells.
Biosci Biotechnol Biochem
2021
PubMed ID: 34245564
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Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N.
Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted fr
Food Chem
2021
360:129822
PubMed ID: 33984564
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15149
Gen Toshima, Takanobu Kiuchi, Yuka Iwama, Haruna Ohrui, Fumiko Kimura, Shiho Nakagawa, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata, Junichiro Takahashi
Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki)
Journal of Biological Macromolecules
2021
21:33-44
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Nguma E, Yamashita S, Kumagai K, Otoki Y, Yamamoto A, Eitsuka T, Nakagawa K, Miyazawa T, Kinoshita M.
Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress.
ACS Omega
2021
6(4):3140-3148
PubMed ID: 33553930
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20293
Arai M, Komori H, Fujita D, Tamai I.
Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
Pharm Res
2021
38(3):523-530
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Kitazawa M, Miyagawa Y, Koyama M, Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu D, Takeoka M, Soejima Y.
Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL.
Mol Clin Oncol
2021
15(1):148
PubMed ID: 34094546
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15288
Akihiro Nishiguchi, Tetsushi Taguchi
Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis
Advanced Functional Materials
2021
2100548
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15412
Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.
Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer
Cancer Sci
2021
112(8):3173-3189
PubMed ID: 34008277
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20369
Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K.
Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.
Mol Ther Nucleic Acids
2021
PubMed ID: 34692233
DOI: 10.1016/j.omtn.2021.10.016
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20384
Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.
Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Mol Pharm
2021
PubMed ID: 34734526
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Suzuki T, Nagata M, Kagawa N, Takano S, Nahrowi, Nomura J.
Anti-Obesity Effects of Matoa ( Pometia pinnata) Fruit Peel Powder in High-Fat Diet-Fed Rats
Molecules
2021
26(21):6733
PubMed ID: 34771142
DOI: 10.3390/molecules26216733
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20406
Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.
High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.
Heliyon
2021
7(11):e08318
PubMed ID: 34816032
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15879
Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.
5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
iScience
2021
24(10):103120
PubMed ID: 34541466
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Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS.
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
Nat Commun
2021
12(1):6602
PubMed ID: 34782627
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Choeisoongnern T, Sirilun S, Waditee-Sirisattha R, Pintha K, Peerajan S, Chaiyasut C.
Potential Probiotic Enterococcus faecium OV3-6 and Its Bioactive Peptide as Alternative Bio-Preservation.
Foods
2021
10(10)
PubMed ID: 34681312
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Arung ET, Ramadhan R, Khairunnisa B, Amen Y, Matsumoto M, Nagata M, Kusuma IW, Paramita S, Sukemi, Yadi, Tandirogang N, Takemoto N, Syafrizal, Kim YU, Shimizu K.
Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
Saudi J Biol Sci
2021
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PubMed ID: 34867021
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Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M.
Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation
Front Oncol9
2021
11:70593
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Takashima Y, Ishikawa K, Miyawaki R, Ogawa M, Ishii T, Misaka T, Kobayashi S.
Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity
J Agric Food Chem
2021
69(33):9585-9596
PubMed ID: 34346218
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16292
Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity
World J Gastroenterol
2021
27(48):8323-8342
PubMed ID: 35068872
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Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A.
Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells
Chem Biol Interact
2021
348:109634
PubMed ID: 34506768
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Komori H, Fujita D, Shirasaki Y, Zhu Q, Iwamoto Y, Nakanishi T, Nakajima M, Tamai I.
MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-Transporting Peptide 2B1/ SLCO2B1 in Caco-2 Cells
Drug Metab Dispos
2021
49(9):803-809
PubMed ID: 34162689
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16369
Abdelbasset Boubakri, Hanen Najjaa, Hanane Maghrebi, Abdelkarim Ben Arfa, Marcos Antonio Das Neves, Hiroko Isoda, Mitsutoshi Nakajima, Mohamed Neffati
Effect of freeze‐drying on the antioxidant and the cytotoxic properties of Allium roseum L. and its application in stabilizing food emulsions
Journal of Food Processing and Preservation
2021
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Nashimoto Y, Abe M, Fujii R, Taira N, Ida H, Takahashi Y, Ino K, Ramon-Azcon J, Shiku H.
Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies
Adv Healthc Mater
2021
10(21):e2101186
PubMed ID: 34409770
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Ito S, Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T.
Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing
Mater Sci Eng C Mater Biol Appl
2021
123:111993
PubMed ID: 33812615
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16728
YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung
Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells
Biodiversitas Journal of Biological Diversity
2021
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Tachibana K, Kondoh M.
A Method to Prepare Claudin-Modulating Recombinant Proteins.
Methods Mol. Biol
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Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H.
α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation.
J. Cell. Biochem
2020
121(2):1238-1249
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Kawahara T, Fujii K, Nakajima K, Fujii R, Inagaki S, Hara K, Yasui H.
Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells.
Planta Med.
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PubMed ID: 31896136
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Meparambu Prabhakaran D, Ramamurthy T, Thomas S.
Genetic and virulence characterisation of Vibrio parahaemolyticus isolated from Indian coast.
BMC Microbiol.
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PubMed ID: 32293257
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Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N.
Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.
Bioorg Med Chem
2020
PubMed ID: 32616184
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Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.
Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
Carbohydr Polym
2020
PubMed ID: 32829826
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Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S.
10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.
Biol Pharm Bull
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PubMed ID: 32741940
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Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.
Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.
J Oleo Sci
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PubMed ID: 32788522
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Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y.
Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.
Int J Oncol
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PubMed ID: 32901840
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Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.
Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.
Biochem Biophys Rep
2020
PubMed ID: 32964147
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Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.
Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
Biochem Biophys Res Commun
2020
PubMed ID: 32977947
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Yamashiro T, Yasujima T, Said HM, Yuasa H.
pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.
J Biol Chem
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PubMed ID: 33008889
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Abe H, Koyama K, Koseki S.
Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.
Appl Environ Microbiol
2020
PubMed ID: 33067190
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Nagata Y, Yamamoto T, Kadowaki M.
Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.
J Nutr Sci Vitaminol (Tokyo)
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PubMed ID: 33132350
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Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi
Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph
BMC
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Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M.
Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route
J Membr Biol
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253(3):221-228
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Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T.
Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice
Cancer Sci
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111(4):1193-1202
PubMed ID: 31997435
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Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M.
Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro
J Oleo Sci
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69(7):751-757
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Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.
Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats
Front Pharmacol
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BaoruiLi et al
Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1
Journal of Functional Foods
2020
75:104273
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Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M.
Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids
Eur J Pharm Sci
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142:10514
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Nakajima T, Sasaki K, Yamamori A, Sakurai K, Miyata K, Watanabe T, Matsunaga YT.
A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays
Biomater Sci
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8(20):5615-5627
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Mu Y, Li J, Kang JH, Eto H, Zai K, Kishimura A, Hyodo F, Mori T, Katayama Y.
A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation
Biol Pharm Bull
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43(9):1413-1420
PubMed ID: 32879216
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Li Z, Zheng J, Luo X, Manabe Y, Hirata T, Sugawara T.
Absorption and Tissue Distribution of Siphonaxanthin from Green Algae
Mar Drugs
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18(6):291
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Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N.
Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria
Vaccine
2020
38(17):3330-3338
PubMed ID: 32197922
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17866
Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu
New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus
Phytochemistry Letters
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32:10-14
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Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N.
NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.
FASEB J.
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Hayashi I, Kanda S, Lamaningao P, Mishima N, Nishiyama T.
Shared expression of mucin12 in Ascaris lumbricoides and the human small intestine.
Mol. Biochem. Parasitol.
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Uchiyama H, Wada Y, Hatanaka Y, Hirata Y, Taniguchi M, Kadota K, Tozuka Y.
Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.
J Pharm Sci
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PubMed ID: 30653971
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Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.
Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
Biochem. Biophys. Res. Commun.
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PubMed ID: 30739789
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Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N.
A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing.
Sci Rep
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PubMed ID: 30894579
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Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.
Biochim Biophys Acta Mol Cell Biol Lipids
2019
PubMed ID: 31351225
DOI: 10.1016/j.bbalip.2019.07.010
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11702
Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki
Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose
Natural Product Communications
2019
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Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.
Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.
Lipids
2019
PubMed ID: 31574565
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Numata T, Sato-Numata K, Okada Y.
Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.
Sci Rep
2019
PubMed ID: 31664151
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Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.
Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.
Cancer Sci
2019
110(12):3708-3717
PubMed ID: 31648389
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6921
Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.
Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.
Nutr Res
2019
72:92-104
PubMed ID: 31767206
DOI: 10.1016/j.nutres.2019.10.010
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6940
Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.
Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.
Pharm Res
2019
37(1):13
PubMed ID: 31873817
DOI: 10.1007/s11095-019-2729-x
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6942
Mahmoud Abdel-Hamid et al
The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage
International Dairy Journal
2019
91:1-8
DOI: 10.1016/j.idairyj.2018.12.007
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6966
Matsuzaki T, Nakamura M, Nogita T, Sato A.
Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.
Biol Pharm Bull
2019
42(6):989-995
PubMed ID: 31155596
DOI: 10.1248/bpb.b19-00011
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9418
Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome
Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha
iosci Microbiota Food Health
2019
38(1):11-22
PubMed ID: 30705798
DOI: 10.12938/bmfh.18-005
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9414
Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2
CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin
Mol Cell Biol
2019
39(16):e00073-19
PubMed ID: 31160493
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
DOI: 10.1080/15592324.2019.1644594
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10420
Sanae Yoshimoto, Keiko Okada, Osamu Hayashi
Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier
Functional Foods in Health and Disease
2019
9(7):466-483
DOI: 10.31989/ffhd.v9i7.611
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10587
Selma Etteieb Jamila Tarhouni Hiroko Isoda
Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures
Water and Environment Journal
2019
33:4-13
DOI: 10.1111/wej.12361
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10588
Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients
Journal of Functional Foods
2019
55:352-361
DOI: 10.1016/j.jff.2019.02.026
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11913
Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.
Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.
Cancers (Basel)
2019
PubMed ID: 31769426
DOI: 10.3390/cancers11121866
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Matsumoto A, Watanabe C, Murakami M.
Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.
Drug Discov Ther
2019
PubMed ID: 31956233
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12437
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
PubMed ID: 30875389
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12517
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
2019
33(2):189-195
PubMed ID: 29457741
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Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.
Biochim. Biophys. Acta
2018
1860:428-433
PubMed ID: 28988777
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Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Toxicol In Vitro
2018
46:284-293
PubMed ID: 29054700
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Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.
Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.
Glycobiology
2018
28:21-31
PubMed ID: 29069492
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Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.
Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
Arch. Biochem. Biophys.
2018
638:58-65
PubMed ID: 29242061
DOI: 10.1016/j.abb.2017.12.010
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10665
Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene
2018
37:1205-1219
PubMed ID: 29242607
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Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Exp. Anim.
2018
67:201-218
PubMed ID: 29276215
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Numata T, Sato-Numata K, Okada Y, Inoue R.
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.
J Nat Med
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72:694-705
PubMed ID: 29569221
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Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.
A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.
Sci Rep
2018
8(1):9008
PubMed ID: 29899364
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Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.
Probiotics in human gut microbiota can degrade host glycosaminoglycans.
Sci Rep
2018
8(1):10674
PubMed ID: 30006634
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Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.
Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.
Mol. Pharm.
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PubMed ID: 30359033
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Sakuta Y, Takehara I, Tsunoda KI, Sato K.
Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.
Anal Sci
2018
PubMed ID: 29806615
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Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
Inflamm. Res.
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67(11-12):975-984
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Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.
Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo.
Biol. Pharm. Bull.
2018
41(2):190-197
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Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown
TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma
Oncotarget
2018
9(26):18480-18493
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Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.
Role of CXC chemokine receptor type 4 as a lactoferrin receptor.
Biochem. Cell Biol.
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Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.
miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.
BMC Cancer
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Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.
Biochem. Biophys. Res. Commun.
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484:543-549
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Takahashi K, Suzuki N, Ogra Y.
Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.
Int J Mol Sci
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Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.
Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.
Eur. J. Pharmacol.
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Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.
Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.
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Carnosine activates the CREB pathway in Caco-2 cells.
Cytotechnology
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69:523-527
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Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.
Oncol Lett
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14:1109-1114
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Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.
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Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Biochem. Pharmacol.
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Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.
Am. J. Chin. Med.
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Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.
J Oleo Sci
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66:1337-1342
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Journal of Functional Foods
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36:274-279
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1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis
Nutrition Research
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46, 59-67
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Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells
Journal of Functional Foods
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39, 91-95
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Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity
Food Science and Technology Research
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23, 725-732
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Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.
A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.
Lab Chip
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Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto
Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers
J Clin Biochem Nutr
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60(2):81-85
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Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga
Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes
Biochem Biophys Res Commun
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486(1):143-148
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Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita
Design and fabrication of devices for investigating cell-sheet stretch
BioChip Journal
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11:173–179
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10028
Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells
Int J Oncol
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Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity
J Gastroenterol Hepatol
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32(11):1839-1845
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Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito
Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications
Front Physiol
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Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.
Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism
Kidney Int
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91(3):658-670
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Acta Biomater
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Sci Rep
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Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.
J Nat Med
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Pharm Biol
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Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters.
Lipids
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Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
J. Biol. Chem.
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Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers.
J. Pharm. Pharmacol.
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H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.
Biochem. Biophys. Res. Commun.
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Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.
Oxid Med Cell Longev
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Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water
Water, Air, & Soil Pollution
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227:341
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The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.
Int J Mol Sci
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Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama
Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis
PLoS One
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11 (1), e0147957
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Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa
The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro
J Vet Med Sci
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78(4):627-32
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Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone
Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells
Nutr Res .
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Katsuya Narumi, Masaki Kobayashi, Ayuko Kondo, Ayako Furugen, Takehiro Yamada, Natsuko Takahashi, Ken Iseki
Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen
Biopharm Drug Dispos
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7(8):447-455
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Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara
An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1
Biol Pharm Bull .
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Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu
New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi
Phytochemistry Letters
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Iwazaki A, Takahashi N, Miyake R, Hiroshima Y, Abe M, Yasui A, Imai K.
Effect of dietary fibers on losartan uptake and transport in Caco-2 cells
Biopharm Drug Dispos
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Gakuro Harada, Pawat Pattarawat, Kenji Ito, Takashi Matsumoto, Takanori Hasegawa, Yoshinori Katakura
Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
Journal of Functional Foods
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Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation
PLoS Genet
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The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.
Infect. Immun.
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The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus.
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Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Biochem. Pharmacol.
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Kaku Y, Tsuchiya A, Kanno T, Nishizaki T.
Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.
Pharmacology
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Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A.
Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.
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Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S.
Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum.
Physiol Rep
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Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA
Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.
Deep Ocean Water Research
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Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura
Enhanced Oleate Uptake and Lipotoxicity Associated With Laurate
FEBS Open Bio . 2015 May 29;5:485-91
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Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura
Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice
Exp Cell Res
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331(2):408-15
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Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto
Jpn J Pharm Health Care Sci
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41(4): 236―243
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Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
Sustained Inhibition of Proton-Coupled Folate Transporter by Myricetin
Drug Metab Pharmacokinet
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30(2):154-9.
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10151
Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato
Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life
Eur J Pharm Sci
2015
67:136-143
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Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki
Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy
J Control Release
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210:19-25
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Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami
Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption
J Nutr Sci Vitaminol (Tokyo)
2015
61(6):449-54
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Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab
Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines
Energy Procedia
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74:878 – 885
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Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe
Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity
J Ethnopharmacol
2015
161:147-55
PubMed ID: 25523370
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10157
Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano
The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells
J Cell Mol Med
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19(7):1569-81
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Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida
Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer
Mol Clin Oncol
2015
3(5):1080-1084
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Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota
Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas
Oncology
2015
88(5):309-19
PubMed ID: 25591719
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Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa
Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation
J Biol Chem
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PubMed ID: 26023238
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Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham
Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats
Nanomedicine
2015
11(5):1227-36
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Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.
MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells
PLoS One
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10(5):e0127119
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Ozeki K, Kato M, Sakurai Y, Ishigai M, Kudo T, Ito K.
Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study
Int J Pharm
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495(2):963-71
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Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T.
An on-chip small intestine-liver model for pharmacokinetic studies
J Lab Autom
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20(3):265-73
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Shimozato O, Waraya M, Nakashima K, Souda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T.
Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation
Oncogene
2015
34(15):1949-60
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Kitajima T, Toiyama Y, Tanaka K, Saigusa S, Kobayashi M, Inoue Y, Mohri Y, Kusunoki M.
Vasohibin-1 increases the malignant potential of colorectal cancer and is a biomarker of poor prognosis
Anticancer Res
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34(10):5321-9
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Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi
Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats
PLoS One
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9(5):e97901
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10198
Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo
Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells
Food Chem
2014
154:145-50
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Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo
Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells
Pestic Biochem Physiol .
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10202
Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki
Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells
Biol Pharm Bull
2014
37(3):490-2
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10203
Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi
Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO)
Life Sci .
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107(1-2):14-20
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10204
Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo
Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters
Biol Pharm Bull .
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37(9):1475-9
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10208
Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani
Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption
Drug Metab Pharmacokinet
2014
29(5):414-8
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10209
Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura
Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation
FEBS Lett .
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588(11):1997-2002
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10223
Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto
Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases
Cancer Chemother Pharmacol
2014
74(5):1023-8
PubMed ID: 25205428
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10224
Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto
Induction of AhR-mediated Gene Transcription by Coffee
PLoS One
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9(7):e102152
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10225
Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin
Drug Metab Pharmacokinet
2014
29(4):312-6
PubMed ID: 24492671
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10226
Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki
Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion
J Pharm Pharm Sci
2014
17(2):266-76
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10229
Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto
Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin
Biopharm Drug Dispos
2014
35(6):321-9
PubMed ID: 24801141
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10237
Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi
Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures
Tumour Biol
2014
35(12):12689-93
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10242
T Nakayama, K Ezoe
Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O
Curr Microbiol .
2014
69(5):690-8
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10243
Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki
Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke
Sci Technol Adv Mater
2014
15(3):035002
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10244
Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation
Immunol Cell Biol
2014
92(7):624-30
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10254
Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi
Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells
J Clin Biochem Nutr
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55(3):162-7
PubMed ID: 25411520
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10259
Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure
Electric Stimulus Opens Intercellular Spaces in Skin
J Biol Chem
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24;289(4):2450-6
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10262
Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane
Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D
FEMS Microbiol Lett
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2014 Aug;357(2):115-22
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Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.
Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.
Biochim Biophys Acta
2013
1832(1):151-9
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12694
Isshiki M, Ohta H, Tamura H.
Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells
Biol Pharm Bull
2013
36(2):299-304
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Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H.
Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells
J Pharm Pharmacol
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65(1):22-9
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Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K.
An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells
3 Biotech
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3(3):213-218
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Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J.
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1
World J Gastroenterol
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19(33):5500-7
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12698
Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H.
Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes
Biol Pharm Bull
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36(11):1862-6
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Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.
Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
J Biol Chem
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288(19):13317-24
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Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.
INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors
Biochem Biophys Res Commun
2013
432(4):586-92
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Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J.
Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery
Eur J Pharm Sci
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50(3-4):303-11
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Kamishikiryo J, Matsumura R, Takamori T, Sugihara N.
Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid
J Pharm Pharmacol
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65(7):1037-43
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Kimura R, Rokkaku T, Takeda S, Senba M, Mori N.
Cytotoxic effects of fucoidan nanoparticles against osteosarcoma
Mar Drugs
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11(11):4267-78
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Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.
Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections
Microb Pathog
2013
65:14-20
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Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N.
Dlg5 interacts with the TGF-β receptor and promotes its degradation
FEBS Lett
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587(11):1624-9
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Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K.
Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides
Int Immunopharmacol
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17(4):1009-19
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Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.
Possible involvement of Wnt11 in colorectal cancer progression
Mol Carcinog
2013
52(3):207-17
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15922
Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.
Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers
Proc Natl Acad Sci U S A
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110(6):2105-10
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KATSUHITO ARAI – TAMIKO YAMAZAKI – YOSHIHIKO TOKUJI – MIKA KAWAHARA – KIYOSHI OHBA – KAZUNORI HIRONAKA – MIKIO KINOSHITA – MASAO OHNISHI
Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice
Journal of Food and Nutrition Research
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52:139–145
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15925
Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S.
Relationship between methyl CpG binding protein 2 and JC viral proteins
Jpn J Infect Dis
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Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.
Oncogene
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Kimura O, Tsukagoshi K, Hayasaka M, Endo T.
Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.
Basic Clin. Pharmacol. Toxicol.
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Ito N, Ohtsubo T, Kusu F, Hakamata H.
An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells.
Anal. Biochem.
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Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F.
Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.
Int J Oncol
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40(1):217-26
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Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto
Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells
J Med Food
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15(6):511-9
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Kimura O, Tsukagoshi K, Hayasaka M, Endo T.
Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells
Arch Toxicol
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Yanagihara S, Hirota T, Yamamoto N.
Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells
J Biosci Bioeng
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Matsuo Y, Miyoshi Y, Okada S, Satoh E.
Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri
Biosci Microbiota Food Health
2012
31(4):93-102
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Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M.
CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer
Eur J Cancer
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48(14):2244-51.
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Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K.
Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins
Acta Med Okayama
2012
66(3):253-61
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Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K.
Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein
J Pharm Pharm Sci
2012
15(2):256-64
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Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.
Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine
J Sci Food Agric
2012
92(4):857-61
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12724
Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M.
Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients
Ann Surg Oncol
2012
19 Suppl 3:S518-27
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Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K.
Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP
J Pharm Pharm Sci
2012
15(2):295-304
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Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO
Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu”
Food Science and Technology Research
2012
18:825-834
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Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N.
Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate
J Food Sci
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77(10):H208-15
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Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.
A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers
Biol Pharm Bull
2012
35(1):1-9
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Chaisowwong W, Kusumoto A, Hashimoto M, Harada T, Maklon K, Kawamoto K.
Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat
J Vet Med Sci
2012
74(1):43-50
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Megumi Ishimura, Mika Sakurai-Yageta, Tomoko Maruyama, Tomoko Ando, Masashi Fukayama, Akiteru Goto, Yoshinori Murakami
Involvement of miR-214 and miR-375 in Malignant Features of Non-Small-Cell Lung Cancer by Down-Regulating CADM1
Journal of Cancer Therapy
2012
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Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.
Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.
Biol. Pharm. Bull.
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Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M.
Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum.
Biomed. Res.
2011
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Isshiki M, Umezawa K, Tamura H.
Coffee induces breast cancer resistance protein expression in Caco-2 cells.
Biol. Pharm. Bull.
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Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M.
Isolation and characterization of a novel short peptide associated with Crohn's disease.
Clin. Exp. Immunol.
2011
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Ashida N, Yanagihara S, Shinoda T, Yamamoto N.
Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.
J. Biosci. Bioeng.
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Kimura O, Kotaki Y, Hamaue N, Haraguchi K, Endo T.
Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.
Food Chem. Toxicol.
2011
49:2167-71
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Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y.
Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.
Biopharm Drug Dispos
2011
32:253-60
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Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.
Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
J. Agric. Food Chem.
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Tsuruta H, Yagishita T, Shimizu M, Tamura H.
Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2.
Toxicol In Vitro
2011
25:500-4
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Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.
Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.
J. Biol. Chem.
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286:2750-61
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Norikura T, Fujiwara K, Narita T, Yamaguchi S, Morinaga Y, Iwai K, Matsue H.
Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta
J Agric Food Chem
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59(13):6974-9
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Imai K, Hirata S, Irie A, Senju S, Ikuta Y, Yokomine K, Harao M, Inoue M, Tomita Y, Tsunoda T, Nakagawa H, Nakamura Y, Baba H, Nishimura Y.
Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer
Br J Cancer
2011
104(2):300-7
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9083
Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai
Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis
Infect Immun
2011
79 (11), 4353-60
PubMed ID: 21911469
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Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda
Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli
Gene
2011
478 (1-2), 1-10
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12742
Takeda S, Yamasaki K, Takeshita M, Kikuchi Y, Tsend-Ayush C, Dashnyam B, Ahhmed AM, Kawahara S, Muguruma M.
The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products
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Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide
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M Gueimonde et al
Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli
Food Research International
2006
39:467-471
DOI: 10.1016/j.foodres.2005.10.003
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12821
Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.
Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer
Toxicology
2006
223(1-2):156-65
PubMed ID: 16647797
DOI: 10.1016/j.tox.2006.03.011
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12822
Ishida K, Takaai M, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2006
29(3):522-6
PubMed ID: 16508158
DOI: 10.1248/bpb.29.522
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12823
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Food Science and Technology Research
2006
12:290-294
DOI: 10.3136/fstr.12.290
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12824
Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
J Gastroenterol
2006
2006 Feb;41(2):140-50
PubMed ID: 16568373
DOI: 10.1007/s00535-005-1733-6
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12825
Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.
Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
Hepatol Res
2006
35(3):152-62
PubMed ID: 16707273
DOI: 10.1016/j.hepres.2006.03.011
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12826
Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.
Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli
Protein Expr Purif
2006
47(1):144-51
PubMed ID: 16307894
DOI: 10.1016/j.pep.2005.10.011
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12827
Makoto KIMURA, Kuninaga DANNO, Hisako YASUI
Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk
Bioscience and Microflora
2006
25:147-155
DOI: 10.12938/bifidus.25.147
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12828
Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.
Determination of p-glycoprotein ATPase activity using luciferase
Biol Pharm Bull
2006
29(3):560-4
PubMed ID: 16508168
DOI: 10.1248/bpb.29.560
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3026
Aiba T, Susa M, Fukumori S, Hashimoto Y
The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180
Drug Metab Pharmacokinet
2005
20:268-274
PubMed ID: 16141606
DOI: 10.2133/dmpk.20.268
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3025
Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya
Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.
Biol Pharm Bull
2005
28:114-9
PubMed ID: 15635174
DOI: 10.1248/bpb.28.114
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3072
Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru
Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.
Biosci Biotechnol Biochem
2005
69:202-5
PubMed ID: 15665486
DOI: 10.1271/bbb.69.202
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3300
Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.
Biol Pharm Bull
2005
28:527-30
PubMed ID: 15744083
DOI: 10.1248/bpb.28.527
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3155
Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu
Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.
Int J Vitam Nutr Res
2005
75:39-46
PubMed ID: 15830920
DOI: 10.1024/0300-9831.75.1.39
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3164
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Biochemistry
2005
44:6343-9
PubMed ID: 15835923
DOI: 10.1021/bi047606a
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3270
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
Hepatol. Res.
2005
33:198-205
PubMed ID: 16198622
DOI: 10.1016/j.hepres.2005.08.005
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9134
Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.
CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS
Chiang Mai Med Bull
2005
44:21-28
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9048
Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye
Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines
J Agric Food Chem
2005
53 (16), 6313-8
PubMed ID: 16076112
DOI: 10.1021/jf0506129
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12832
Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2
Food Science and Technology Research
2005
11:202-206
DOI: 10.3136/fstr.11.202
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12833
Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.
The effects of coffee on conjugation reactions in human colon carcinoma cells
Biol Pharm Bull
2005
28(2):271-4
PubMed ID: 15684482
DOI: 10.1248/bpb.28.271
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12835
Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.
Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
Biochim Biophys Acta
2005
1732(1-3):43-52
PubMed ID: 16380173
DOI: 10.1016/j.bbaexp.2005.11.003
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2720
Saegusa S, Totsuka M, Kaminogawa S, Hosoi T
Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.
FEMS Immunol Med Microbiol
2004
41:227-35
PubMed ID: 15196572
DOI: 10.1016/j.femsim.2004.03.006
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2736
Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi
Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.
Eur J Pharm Sci
2004
21:87-95
PubMed ID: 14706815
DOI: 10.1016/j.ejps.2003.10.002
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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2735
Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi
Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.
Biol Pharm Bull
2004
27:559-63
PubMed ID: 15056866
DOI: 10.1248/bpb.27.559
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3199
Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji
Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.
Am J Physiol Cell Physiol
2004
287:C1404-11
PubMed ID: 15229109
DOI: 10.1152/ajpcell.00471.2003
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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3094
Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Cancer Res
2004
64:6410-5
PubMed ID: 15374948
DOI: 10.1158/0008-5472.CAN-04-1543
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2708
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.
Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.
J. Exp. Clin. Cancer Res.
2004
23:69-75
PubMed ID: 15149153
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3066
Aida K. et al.
Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.
J Oleo Sci.
2004
53:503-510
DOI: 10.5650/jos.53.503
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4723
Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.
Oncol Res
2004
14(9):407-14
PubMed ID: 15490972
DOI: 10.3727/0965040041791464
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12839
Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.
Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells
Biosci Biotechnol Biochem
2004
68(12):2541-6
PubMed ID: 15618625
DOI: 10.1271/bbb.68.2541
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12840
Shigeaki Okamura, Hiro-omi Tamura
Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2
Journal of Health Science
2004
50:189-192
DOI: 10.1248/jhs.50.189
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
DOI: 10.1177/026119290403201s15
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12843
Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.
Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids
Cell Transplant
2004
13(4):463-73
PubMed ID: 15468688
DOI: 10.3727/000000004783983882
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
DOI: 10.1016/j.bcp.2003.11.002
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2268
Sue Hyung Choi, Osamu Fukuda, Akiyoshi Sakoda, Yasuyuki Sakai
Enhanced cytochrome P450 capacities of Caco-2 and Hep G2 cells in new coculture system under the static and perfused conditions: evidence for possible organ-to-organ interactions against exogenous stimuli
Materials Science and Engineering: C
2004
24:33-339
DOI: 10.1016/j.msec.2003.12.002
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2645
Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi
Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).
Int J Food Microbiol
2003
82:255-64
PubMed ID: 12593928
DOI: 10.1016/s0168-1605(02)00311-2
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3042
Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo
An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.
Biochim Biophys Acta
2003
1612:186-94
PubMed ID: 12787937
DOI: 10.1016/s0005-2736(03)00130-5
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18851
Sugawara T, Kinoshita M, Ohnishi M, Nagata J, Saito M.
Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cells
J Nutr
2003
133(9):2777-82
PubMed ID: 12949364
DOI: 10.1093/jn/133.9.2777
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3791
Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Pharm Res
2003
20(2):324-7
PubMed ID: 12636175
DOI: 10.1023/a:1022251910820
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3792
Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.
Growth promoting effect of thioredoxin on intestinal epithelial cells.
Dig Dis Sci
2003
48(2):379-85
PubMed ID: 12643619
DOI: 10.1023/a:1021952132241
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
DOI: 10.1007/s10047-003-0238-4
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3796
Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.
Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.
Int J Cancer
2003
107(1):53-9
PubMed ID: 12925956
DOI: 10.1002/ijc.11348
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2734
Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:885-90
PubMed ID: 12132663
DOI: 10.1248/bpb.25.885
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2629
Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji
Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.
Biochem Biophys Res Commun
2002
296:625-30
PubMed ID: 12176027
DOI: 10.1016/s0006-291x(02)00853-7
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2633
Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:1345-50
PubMed ID: 12392092
DOI: 10.1248/bpb.25.1345
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3750
Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.
Microbiol Immunol
2002
46(4):293-7
PubMed ID: 12061632
DOI: 10.1111/j.1348-0421.2002.tb02698.x
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3779
Yamauchi K, Komatsu T, Kulkarni AD, Ohmori Y, Minami H, Ushiyama Y, Nakayama M, Yamamoto S.
Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis.
Nutrition
2002
18(4):329-33
PubMed ID: 11934546
DOI: 10.1016/s0899-9007(01)00788-2
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3781
Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ.
Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells.
Biol Pharm Bull
2002
25(3):393-6
PubMed ID: 11913542
DOI: 10.1248/bpb.25.393
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3783
Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.
Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.
J Gastroenterol
2002
37(11):896-904
PubMed ID: 12483244
DOI: 10.1007/s005350200151
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16630
Nakamura T, Sakaeda T, Ohmoto N, Tamura T, Aoyama N, Shirakawa T, Kamigaki T, Nakamura T, Kim KI, Kim SR, Kuroda Y, Matsuo M, Kasuga M, Okumura K.
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas
Drug Metab Dispos
2002
30(1):4-6
PubMed ID: 11744604
DOI: 10.1124/dmd.30.1.4
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2554
Tamura, H., and Matsui, M.
Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
J Health Science
2001
47:468-472
DOI: 10.1248/jhs.47.468
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2544
Todoriki K, Mukai T, Sato S, Toba T
Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.
J Appl Microbiol
2001
91:154-9
PubMed ID: 11442725
DOI: 10.1046/j.1365-2672.2001.01371.x
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2553
Isozaki T, Tamura H
Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2001
24:1076-8
PubMed ID: 11558573
DOI: 10.1248/bpb.24.1076
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2550
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F
Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.
Biol Pharm Bull
2001
24:1258-62
PubMed ID: 11725959
DOI: 10.1248/bpb.24.1258
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3768
Takeuchi K, Mizuno M, Uesu T, Nasu J, Kawada M, Hori S, Okada H, Endo Y, Fujita T, Tsuji T.
Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway.
J Lab Clin Med
2001
138(3):186-92
PubMed ID: 11528371
DOI: 10.1067/mlc.2001.117405
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3771
Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.
DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Cancer Genet Cytogenet
2001
126(1):34-8
PubMed ID: 11343776
DOI: 10.1016/s0165-4608(00)00391-5
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3772
Ijichi H, Ikenoue T, Kato N, Mitsuno Y, Togo G, Kato J, Kanai F, Shiratori Y, Omata M.
Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.
Biochem Biophys Res Commun
2001
289(2):350-7
PubMed ID: 11716479
DOI: 10.1006/bbrc.2001.5988
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3774
Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S.
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.
Biochem Biophys Res Commun
2001
280(5):1216-23
PubMed ID: 11162657
DOI: 10.1006/bbrc.2001.4267
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16964
Ohishi K, Aiyama R, Hatano H, Yoshida Y, Wada Y, Yokoi W, Sawada H, Watanabe T, Yokokura T.
Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase
Chem Pharm Bull (Tokyo)
2001
49(7):830-9
PubMed ID: 11456087
DOI: 10.1248/cpb.49.830
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2551
Tamura H, Matsui M
Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:695-9
PubMed ID: 10864017
DOI: 10.1248/bpb.23.695
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2552
Satoh T, Matsui M, Tamura H
Sulfotransferases in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:810-4
PubMed ID: 10919357
DOI: 10.1248/bpb.23.810
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3780
Endo T, Kimura O, Saitoh H, Sakata M.
Secretory transport of cadmium through intestinal brush border membrane via H(+)-antiport.
Toxicology
2000
150(1-3):129-36
PubMed ID: 10996669
DOI: 10.1016/s0300-483x(00)00248-1
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3761
Nakayama A, Saitoh H, Oda M, Takada M, Aungst BJ.
Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system.
Eur J Pharm Sci
2000
11(4):317-24
PubMed ID: 11033075
DOI: 10.1016/s0928-0987(00)00113-5
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3763
Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.
Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.
Biochem Biophys Res Commun
2000
19;267(2):658-62
PubMed ID: 10631118
DOI: 10.1006/bbrc.1999.2010
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3758
Miyata R, Iwabuchi K, Watanabe S, Sato N, Nagaoka I.
Short exposure of intestinal epithelial cells to TNF-alpha and histamine induces Mac-1-mediated neutrophil adhesion independent of protein synthesis.
J Leukoc Biol
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66(3):437-46
PubMed ID: 10496314
DOI: 10.1002/jlb.66.3.437
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