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19855
Kida R, Tsugane M, Suzuki H.
Horizontal and vertical microchamber platforms for evaluation of the paracellular permeability of an epithelial cell monolayer
Lab Chip
2024
24(3):572-583
PubMed ID: 38175144
DOI: 10.1039/d3lc00855j
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19990
Kiriko Iida, Asuka Iwasa, Yuuki Amano, Koshu Okubo, Junichi Hirahashi, Hiroshi Kawakami
Preventive effect of lactoferrin peptides on ulcerative colitis
International Dairy Journal
2024
150:105832
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21644
Nonaka S, Okamoto R, Katsuta Y, Kanetsuki S, Nakanishi H.
Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol.
Biochem Biophys Res Commun
2024
707:149783
PubMed ID: 38493746
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21669
Miyasaka K, Takada R, Wu J, Takeda S, Manse Y, Morikawa T, Shimoda H.
Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption.
J Nat Med
2024
PubMed ID: 38587581
DOI: 10.1007/s11418-024-01791-5
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21702
Ikuno Y, Tsujino H, Haga Y, Manabe S, Idehara W, Hokaku M, Asahara H, Higashisaka K, Tsutsumi Y.
Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.
Ecotoxicol Environ Saf
2024
277:116346
PubMed ID: 38669869
DOI: 10.1016/j.ecoenv.2024.116346
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21709
Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T.
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
J Gastroenterol
2024
PubMed ID: 38695904
DOI: 10.1007/s00535-024-02104-z
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21729
Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Niitsuma F, Kawahara T, Watanabe J, Tanaka S.
Heat-killed Lactiplantibacillus plantarum Shinshu N-07 exerts antiobesity effects in western diet-induced obese mice.
J Appl Microbiol
2024
PubMed ID: 38740521
DOI: 10.1093/jambio/lxae119
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21747
Nagasawa M, Onuki M, Imoto N, Tanaka K, Tanaka R, Kawada M, Imato K, Iitani K, Tsuchido Y, Takeda N.
Fabrication of 3D engineered intestinal tissue producing abundant mucus by air-liquid interface culture using paper-based dual-layer scaffold.
Biofabrication
2024
PubMed ID: 38788705
DOI: 10.1088/1758-5090/ad504b
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21748
Nakatani E, Sasai M, Miyazaki H, Tanaka S, Hirota T, Okura T.
Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in Caco-2 Cells.
J Agric Food Chem
2024
PubMed ID: 38789103
DOI: 10.1021/acs.jafc.4c00974
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21790
Fujita S, Plianchaisuk A, Deguchi S, Ito H, Nao N, Wang L, Nasser H, Tamura T, Kimura I, Kashima Y, Suzuki R, Suzuki S, Kida I, Tsuda M, Oda Y, Hashimoto R, Watanabe Y, Uriu K, Yamasoba D, Guo Z, Hinay AA Jr, Kosugi Y, Chen L, Pan L, Kaku Y, Chu H, Donati F, Temmam S, Eloit M, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Suzuki Y, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Ikeda T, Tanaka S, Matsuno K, Fukuhara T, Takayama K, Sato K.
Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236.
EBioMedicine
2024
104:105181
PubMed ID: 38838469
DOI: 10.1016/j.ebiom.2024.105181
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21877
Tanabe T, Tsukamoto M, Shioda M, Nagaoka K, Funahashi T.
Expression regulation of type III secretion system 2 in Vibrio parahaemolyticus by catabolite activator protein.
FEMS Microbiol Lett
2024
PubMed ID: 39054297
DOI: 10.1093/femsle/fnae054
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21961
Koizumi A, Kaji K, Nishimura N, Asada S, Matsuda T, Tanaka M, Yorioka N, Tsuji Y, Kitagawa K, Sato S, Namisaki T, Akahane T, Yoshiji H.
Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease.
World J Gastroenterol
2024
30(28):3428-3446
PubMed ID: 39091710
DOI: 10.3748/wjg.v30.i28.3428
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21964
Kurosu J, Sakamaki T, Kanai K, Morishita K, Sumaru K, Tsutsumi J.
Spatiotemporal dynamics of microscopic biological barrier visualized by electric-double-layer modulation imaging.
Biosens Bioelectron
2024
266:116721
PubMed ID: 39226753
DOI: 10.1016/j.bios.2024.116721
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21987
Lina Yonekura, Haruka Hisada, Jittipon Intravichakul
Human α-glucosidase inhibition and phytochemical profile of natural and shinzuke treated olives: implications from the processing method
Food Production, Processing and Nutrition
2024
6
DOI: 10.1186/s43014-024-00227-7
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22092
Itoh T, Miyazono D, Sugata H, Mori C, Takahata M.
Anti-inflammatory effects of heat-killed Lactiplantibacillus argentoratensis BBLB001 on a gut inflammation co-culture cell model and dextran sulfate sodium-induced colitis mouse model.
Int Immunopharmacol
2024
143(Pt 2):113408
PubMed ID: 39461236
DOI: 10.1016/j.intimp.2024.113408
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22153
Takizawa Y, Furuya T, Uno M, Ohashi R, Mimura E, Kurita T, Nakajima T.
Specific inhibitory effects of exogenous d-Aspartate on the proliferation of intestinal epithelial cells.
Biochem Biophys Res Commun
2024
734:150659
PubMed ID: 39245027
DOI: 10.1016/j.bbrc.2024.150659
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17773
Watanabe K, Negoro R, Fujita T.
5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells
Biochem Biophys Res Commun
2023
664:94-99
PubMed ID: 37141642
DOI: 10.1016/j.bbrc.2023.04.077
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17774
Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H.
Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells
Biosci Biotechnol Biochem
2023
zbad030
PubMed ID: 36941128
DOI: 10.1093/bbb/zbad030
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17775
Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima
The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells
J. Excipients and Food Chem
2023
14:22-32
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17776
Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.
Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels
BMC Cancer
2023
23(1):356
PubMed ID: 37072777
DOI: 10.1186/s12885-023-10845-y
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17778
Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα
Drug Metabolism and Pharmacokinetics
2023
DOI: 10.1016/j.dmpk.2023.100512
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17779
Sansawat, A., Ratanacoon, M. and Nitteranon, V.
Antioxidative, anti-inflammatory, antibacterial, and anti- adhesive activities of different solvent extracts from various parts of Basella rubra L.
International Journal of Agricultural Technology
2023
19(2):655-668
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17780
Zhu Q, Iwai R, Okaguchi T, Shirasaka Y, Tamai I.
Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT
Food Funct
2023
May 2
PubMed ID: 37129213
DOI: 10.1039/d3fo00510k
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19578
Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound
Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound
Molecules
2023
28(11):4549
PubMed ID: 37299024
DOI: 10.3390/molecules28114549
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19634
Tomii A, Higa M, Naito K, Kurata K, Kobayashi J, Takei C, Yuasa K, Koto Y, Shimizu H.
Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cells
Biosci Biotechnol Biochem
2023
87(8):839-849
PubMed ID: 37147026
DOI: 10.1093/bbb/zbad055
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19662
Yusuke Takizawa, Naruya Kunii, Takanori Nakajima
Comparison of pharmaceutical characteristics and membrane permeability of truvada combination tablets and its generic drugs
Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector
2023
19
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19704
Orita T, Chogahara S, Okuda M, Sakao K, Miyata T, Hou DX.
Extraction Efficiency and Alpha-Glucosidase Inhibitory Activities of Green Tea Catechins by Different Infusion Methods
Foods
2023
12(13):2611.
PubMed ID: 37444349
DOI: 10.3390/foods12132611
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19835
Sugihara N, Okada Y, Tomioka A, Ito S, Tanemoto R, Nishii S, Mizoguchi A, Inaba K, Hanawa Y, Horiuchi K, Wada A, Akita Y, Higashiyama M, Kurihara C, Komoto S, Tomita K, Hokari R.
Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome
Gut Liver
2023
Jun 9
PubMed ID: 37291901
DOI: 10.5009/gnl220100
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19840
Alghurabi H, Jassim Muhammad H, Tagami T, Ogawa K, Ozeki T.
Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid
Int J Pharm
2023
648:123597.
PubMed ID: 37952559
DOI: 10.1016/j.ijpharm.2023.123597
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19883
Maruyama M, Yoshikata M, Sakaguchi M, Wakushima S, Higaki K.
Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs
Int J Pharm
2023
633:122617
PubMed ID: 36657552
DOI: 10.1016/j.ijpharm.2023.122617
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19917
Ishioka K, Miyazaki N, Nishiyama K, Suzutani T.
Characterization of Lactococcus lactis 11/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic
Microorganisms
2023
11(12):2949
PubMed ID: 38138093
DOI: 10.3390/microorganisms11122949
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19918
Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I.
Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation
Toxicol Mech Methods
2023
33(9):741-754
PubMed ID: 37496379
DOI: 10.1080/15376516.2023.2238061
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19925
Mukai H, Takanashi M, Ogawara KI, Maruyama M, Higaki K.
Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers
J Pharm Sci
2023
S0022-3549(23)00486-0
PubMed ID: 37984697
DOI: 10.1016/j.xphs.2023.11.010
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19943
Koyama Y, Fujihara S, Chiyo T, Matsui T, Hamaya S, Fujita K, Tani J, Morishita A, Kobara H, Ono M, Iwama H, Masaki T.
Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer
In Vivo
2023
37(5):1980-1990
PubMed ID: 37652512
DOI: 10.21873/invivo.13295
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19959
Tamura S, Tazawa H, Hori N, Li Y, Yamada M, Kikuchi S, Kuroda S, Urata Y, Kagawa S, Fujiwara T.
p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells
PLoS One
2023
18(11):e0294491
PubMed ID: 37972012
DOI: 10.1371/journal.pone.0294491
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13874
Yamada N, Negoro R, Watanabe K, Fujita T.
Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system
Drug Metab Pharmacokinet
2023
50:100497.
PubMed ID: 37037169
DOI: 10.1016/j.dmpk.2023.100497
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21020
Kudo K, Kobayashi T, Kasai K, Nozaka H, Nakamura T.
Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α.
Biochem Biophys Res Commun
2023
642:185-191
PubMed ID: 36586186
DOI: 10.1016/j.bbrc.2022.12.051
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21021
Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T.
Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Biochim Biophys Acta Mol Cell Res
2023
1870(2):119404
PubMed ID: 36535369
DOI: 10.1016/j.bbamcr.2022.119404
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21182
Tsubaki M, Takeda T, Matsuda T, Kishimoto K, Takefuji H, Taniwaki Y, Ueda M, Hoshida T, Tanabe K, Nishida S.
Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy.
Cancer Cell Int
2023
23(1):73
PubMed ID: 37069612
DOI: 10.1186/s12935-023-02884-z
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21203
Kuriya K, Goto S, Kobayashi E, Nishio M, Nakamura M, Umekawa H.
Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols.
Mol Biol Rep
2023
PubMed ID: 37160631
DOI: 10.1007/s11033-023-08481-7
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21281
Lyu M, Bai Y, Orihara K, Miyanaga K, Yamamoto N.
GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions.
Microorganisms
2023
11(6)
PubMed ID: 37374895
DOI: 10.3390/microorganisms11061393
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21285
Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E.
Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.
Biochem Biophys Res Commun
2023
672:72-80
PubMed ID: 37343317
DOI: 10.1016/j.bbrc.2023.06.017
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21307
Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.
Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.
Ann Surg Oncol
2023
PubMed ID: 37407874
DOI: 10.1245/s10434-023-13779-8
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21310
Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T.
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
J Gastroenterol
2023
PubMed ID: 37410250
DOI: 10.1007/s00535-023-02016-4
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21358
Yamaguchi R, Kanie Y, Kazamaki T, Kanie O, Shimizu Y.
Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells.
Carbohydr Res
2023
532:108921
PubMed ID: 37562111
DOI: 10.1016/j.carres.2023.108921
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21419
Shibamoto A, Kaji K, Nishimura N, Kubo T, Iwai S, Tomooka F, Suzuki J, Tsuji Y, Fujinaga Y, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin.
J Nutr Biochem
2023
109450
PubMed ID: 37777163
DOI: 10.1016/j.jnutbio.2023.109450
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21424
Kataoka M, Kitazawa M, Nakamura S, Koyama M, Yamamoto Y, Miyazaki S, Hondo N, Tanaka H, Soejima Y.
Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment.
Anticancer Res
2023
43(10):4341-4348
PubMed ID: 37772552
DOI: 10.21873/anticanres.16629
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21445
Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M.
Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.
Pharmaceutics
2023
15(9)
PubMed ID: 37765306
DOI: 10.3390/pharmaceutics15092338
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21455
Hiranphinyophat S, Hiraoka T, Kobayashi M, Fujii S, Kishida A, Tanabe T, Kimura T, Yamamoto M.
Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies.
Langmuir
2023
PubMed ID: 37882450
DOI: 10.1021/acs.langmuir.3c01858
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21494
Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine.
Biol Pharm Bull
2023
46(12):1745-1752
PubMed ID: 38044133
DOI: 10.1248/bpb.b23-00479
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21521
Kiba Y, Tanikawa T, Hayashi T, Kamauchi H, Seki T, Suzuki R, Kitamura M.
Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains.
Biomed Pharmacother
2023
169:115940
PubMed ID: 38007936
DOI: 10.1016/j.biopha.2023.115940
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17506
Hashizume J, Sato K, Nakagawa H, Harasawa H, Honda T, Kodama Y.
Examination of the Effect of Proton Pump Inhibitors on the Anticancer Activity of Oxaliplatin
Cancer Diagn Progn
2022
2(6):620-626
PubMed ID: 36340458
DOI: 10.21873/cdp.10151
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17564
Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells
Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells
Journal of Applied Pharmaceutical Science
2022
147-159
DOI: 10.7324/japs.2022.120715
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17586
Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, Yamaji R.
Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide
J Agric Food Chem
2022
70(49):15499-15508
PubMed ID: 36458736
DOI: 10.1021/acs.jafc.2c06791
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14784
Ariumi Y.
Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection
J Virol
2022
96(6):e0000222
PubMed ID: 35107372
DOI: 10.1128/jvi.00002-22
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15564
Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T.
Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system
Arch Toxicol
2022
Oct 16
PubMed ID: 34654938
DOI: 10.1007/s00204-021-03175-0
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20541
Shinji S, Shichi Y, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Yonaga K, Iwai T, Takeda K, Ueda K, Kuriyama S, Miyasaka T, Ueda Y, Sasaki N, Takahashi K, Ohashi R, Ishiwata T, Arai T, Yoshida H.
A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor
J Nippon Med Sch
2022
89(4):368-376
PubMed ID: 35082206
DOI: 10.1272/jnms.JNMS.2022_89-402
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16347
Naoki Murata, Saki Keitoku, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata
Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers
Natural Product Communications
2022
17:1934578X2110704
DOI: 10.1177/1934578x211070415
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16348
Inada A, Sawao A, Takahashi K, Oshima T.
Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate
J Food Sci
2022
87(3):1174-1183
PubMed ID: 35122241
DOI: 10.1111/1750-3841.16049
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16349
Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S.
PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells
Oncol Lett
2022
23(4):106
PubMed ID: 35242234
DOI: 10.3892/ol.2022.13226
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20603
Diao X, Yamada K, Shibata Y, Imada C.
Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide.
Mar Drugs
2022
20(2)
PubMed ID: 35200617
DOI: 10.3390/md20020087
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20610
Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.
TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.
Biochem Biophys Rep
2022
30:101239
PubMed ID: 35252596
DOI: 10.1016/j.bbrep.2022.101239
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20640
Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A.
Indigo plant leaf extract inhibits the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2.
Exp Ther Med
2022
23(4):274
PubMed ID: 35251340
DOI: 10.3892/etm.2022.11200
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20686
Enomoto M, Kaji K, Nishimura N, Fujimoto Y, Murata K, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.
Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.
Dig Liver Dis
2022
PubMed ID: 35514019
DOI: 10.1016/j.dld.2022.04.012
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20699
Takahashi Y, Abe H, Koayama K, Koseki S.
Modeling the invasion of human small intestinal epithelial-like cells by Salmonella enterica Typhimurium and Listeria monocytogenes using Bayesian inference.
Lett Appl Microbiol
2022
PubMed ID: 35575530
DOI: 10.1111/lam.13738
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16510
Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu
Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation
Toxicology Reports
2022
9:937-944
PubMed ID: 35875256
DOI: 10.1016/j.toxrep.2022.04.019
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Biopharm Drug Dispos
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Life Sci Alliance
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Biol Trace Elem Res
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Biol Pharm Bull
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Eur J Pharmacol
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Lipids Health Dis
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Int J Environ Res Public Health
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Pharm Res
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PLoS One
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MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Sci Rep
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PLoS Pathog
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TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells.
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Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki)
Journal of Biological Macromolecules
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Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress.
ACS Omega
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Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
Pharm Res
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Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL.
Mol Clin Oncol
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Akihiro Nishiguchi, Tetsushi Taguchi
Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis
Advanced Functional Materials
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Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.
Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer
Cancer Sci
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Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.
Mol Ther Nucleic Acids
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Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Mol Pharm
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Anti-Obesity Effects of Matoa ( Pometia pinnata) Fruit Peel Powder in High-Fat Diet-Fed Rats
Molecules
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High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.
Heliyon
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7(11):e08318
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5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
iScience
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SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
Nat Commun
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Potential Probiotic Enterococcus faecium OV3-6 and Its Bioactive Peptide as Alternative Bio-Preservation.
Foods
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Arung ET, Ramadhan R, Khairunnisa B, Amen Y, Matsumoto M, Nagata M, Kusuma IW, Paramita S, Sukemi, Yadi, Tandirogang N, Takemoto N, Syafrizal, Kim YU, Shimizu K.
Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
Saudi J Biol Sci
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Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M.
Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation
Front Oncol9
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Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity
J Agric Food Chem
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Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity
World J Gastroenterol
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Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A.
Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells
Chem Biol Interact
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Komori H, Fujita D, Shirasaki Y, Zhu Q, Iwamoto Y, Nakanishi T, Nakajima M, Tamai I.
MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-Transporting Peptide 2B1/ SLCO2B1 in Caco-2 Cells
Drug Metab Dispos
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Abdelbasset Boubakri, Hanen Najjaa, Hanane Maghrebi, Abdelkarim Ben Arfa, Marcos Antonio Das Neves, Hiroko Isoda, Mitsutoshi Nakajima, Mohamed Neffati
Effect of freeze‐drying on the antioxidant and the cytotoxic properties of Allium roseum L. and its application in stabilizing food emulsions
Journal of Food Processing and Preservation
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Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies
Adv Healthc Mater
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Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing
Mater Sci Eng C Mater Biol Appl
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YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung
Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells
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Planta Med.
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Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.
Bioorg Med Chem
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Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
Carbohydr Polym
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10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.
Biol Pharm Bull
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Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.
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J Oleo Sci
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Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.
Int J Oncol
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Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.
Biochem Biophys Rep
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Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.
Biochem Biophys Res Commun
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pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.
J Biol Chem
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Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.
Appl Environ Microbiol
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Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.
J Nutr Sci Vitaminol (Tokyo)
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Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi
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BMC
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Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice
Cancer Sci
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Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro
J Oleo Sci
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Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats
Front Pharmacol
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Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1
Journal of Functional Foods
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Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids
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A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays
Biomater Sci
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A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation
Biol Pharm Bull
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Li Z, Zheng J, Luo X, Manabe Y, Hirata T, Sugawara T.
Absorption and Tissue Distribution of Siphonaxanthin from Green Algae
Mar Drugs
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Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N.
Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria
Vaccine
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38(17):3330-3338
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17866
Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu
New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus
Phytochemistry Letters
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FASEB J.
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Mol. Biochem. Parasitol.
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Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.
J Pharm Sci
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Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.
Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
Biochem. Biophys. Res. Commun.
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Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N.
A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing.
Sci Rep
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PubMed ID: 30894579
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Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.
Biochim Biophys Acta Mol Cell Biol Lipids
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PubMed ID: 31351225
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Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki
Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose
Natural Product Communications
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Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.
Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.
Lipids
2019
PubMed ID: 31574565
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Numata T, Sato-Numata K, Okada Y.
Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.
Sci Rep
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PubMed ID: 31664151
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Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.
Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.
Cancer Sci
2019
110(12):3708-3717
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Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.
Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.
Nutr Res
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72:92-104
PubMed ID: 31767206
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6940
Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.
Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.
Pharm Res
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37(1):13
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Mahmoud Abdel-Hamid et al
The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage
International Dairy Journal
2019
91:1-8
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6966
Matsuzaki T, Nakamura M, Nogita T, Sato A.
Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.
Biol Pharm Bull
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42(6):989-995
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9418
Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome
Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha
iosci Microbiota Food Health
2019
38(1):11-22
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9414
Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2
CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin
Mol Cell Biol
2019
39(16):e00073-19
PubMed ID: 31160493
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
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10420
Sanae Yoshimoto, Keiko Okada, Osamu Hayashi
Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier
Functional Foods in Health and Disease
2019
9(7):466-483
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10587
Selma Etteieb Jamila Tarhouni Hiroko Isoda
Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures
Water and Environment Journal
2019
33:4-13
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10588
Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients
Journal of Functional Foods
2019
55:352-361
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Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.
Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.
Cancers (Basel)
2019
PubMed ID: 31769426
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Matsumoto A, Watanabe C, Murakami M.
Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.
Drug Discov Ther
2019
PubMed ID: 31956233
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Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
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14(3):e0214000
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Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
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33(2):189-195
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Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.
Biochim. Biophys. Acta
2018
1860:428-433
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Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.
Toxicol In Vitro
2018
46:284-293
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Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.
Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.
Glycobiology
2018
28:21-31
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Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.
Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
Arch. Biochem. Biophys.
2018
638:58-65
PubMed ID: 29242061
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Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene
2018
37:1205-1219
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Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Exp. Anim.
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67:201-218
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Numata T, Sato-Numata K, Okada Y, Inoue R.
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.
J Nat Med
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72:694-705
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Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.
A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.
Sci Rep
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8(1):9008
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Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.
Probiotics in human gut microbiota can degrade host glycosaminoglycans.
Sci Rep
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Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.
Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.
Mol. Pharm.
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Sakuta Y, Takehara I, Tsunoda KI, Sato K.
Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.
Anal Sci
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Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
Inflamm. Res.
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Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.
Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo.
Biol. Pharm. Bull.
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Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown
TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma
Oncotarget
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9(26):18480-18493
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Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.
Role of CXC chemokine receptor type 4 as a lactoferrin receptor.
Biochem. Cell Biol.
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Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.
miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.
BMC Cancer
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Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.
Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.
Biochem. Biophys. Res. Commun.
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484:543-549
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Takahashi K, Suzuki N, Ogra Y.
Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.
Int J Mol Sci
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Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.
Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.
Eur. J. Pharmacol.
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Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.
Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.
J. Food Sci.
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Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y.
Carnosine activates the CREB pathway in Caco-2 cells.
Cytotechnology
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69:523-527
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Nakayama T, Funakoshi-Tago M, Tamura H.
Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.
Oncol Lett
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Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.
Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.
Toxicol. Lett.
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Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.
Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.
Biochem. Pharmacol.
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Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.
Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.
Am. J. Chin. Med.
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Yamashita S, Seino T, Aida K, Kinoshita M.
Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.
J Oleo Sci
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Effect of luteolin on the expression of intestinal cholesterol transporters
Journal of Functional Foods
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36:274-279
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1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis
Nutrition Research
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46, 59-67
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Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells
Journal of Functional Foods
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39, 91-95
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Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity
Food Science and Technology Research
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23, 725-732
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Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.
A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.
Lab Chip
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Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto
Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers
J Clin Biochem Nutr
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60(2):81-85
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Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga
Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes
Biochem Biophys Res Commun
2017
486(1):143-148
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Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita
Design and fabrication of devices for investigating cell-sheet stretch
BioChip Journal
2017
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Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells
Int J Oncol
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Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity
J Gastroenterol Hepatol
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32(11):1839-1845
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Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito
Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications
Front Physiol
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Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.
Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism
Kidney Int
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91(3):658-670
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Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.
Acta Biomater
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HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.
Anticancer Res.
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Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T.
Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.
Int. J. Oncol.
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Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.
Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.
Sci Rep
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Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer
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Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas
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Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats
Nanomedicine
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Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats
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Food Chem
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Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo
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Drug Metab Pharmacokinet
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Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases
Cancer Chemother Pharmacol
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Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa
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Drug Metab Pharmacokinet
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Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki
Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion
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Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto
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Biopharm Drug Dispos
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Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures
Tumour Biol
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Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke
Sci Technol Adv Mater
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Immunol Cell Biol
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Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells
J Clin Biochem Nutr
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Electric Stimulus Opens Intercellular Spaces in Skin
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Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D
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Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells
Biol Pharm Bull
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32(3):513-6
PubMed ID: 19252307
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12763
Kazuhiro Yamamoto, Hideki Hakamata, Akira Yamaguchi, Fumiyo Kusu
An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers
Anal Bioanal Chem
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395(2):533-8
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12765
Fukumori S, Masago M, Ishida K, Kayano Y, Taguchi M, Hashimoto Y.
Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells
Biopharm Drug Dispos
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30(8):448-56
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12773
Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y.
Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma
Biochem Biophys Res Commun
2009
383(4):480-4
PubMed ID: 19371721
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8700
Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.
Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.
Biosci. Biotechnol. Biochem.
2008
72:3148-57
PubMed ID: 19060399
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8715
Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.
Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.
J. Agric. Food Chem.
2008
56:10515-20
PubMed ID: 18959405
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Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.
Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.
Biol. Pharm. Bull.
2008
31:949-54
PubMed ID: 18451525
DOI: 10.1248/bpb.31.949
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10207
Ayako Saruwatari, Shigeaki Okamura, Yoko Nakajima, Yuji Narukawa, Tadahiro Takeda, Hiroomi Tamura
Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells
J Med Food
2008
11(4):623-8
PubMed ID: 19053852
DOI: 10.1089/jmf.2007.0050
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12774
Saruwatari A, Isshiki M, Tamura H.
Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells
iol Pharm Bull
2008
31(11):2131-6
PubMed ID: 18981586
DOI: 10.1248/bpb.31.2131
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12775
Seki T, Harada S, Hosoya O, Morimoto K, Juni K.
Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes
Biol Pharm Bull
2008
31(1):163-6
PubMed ID: 18175963
DOI: 10.1248/bpb.31.163
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12776
Kimura O, Tsukagoshi K, Endo T.
Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter
Toxicol Appl Pharmacol
2008
227(3):325-30
PubMed ID: 18096194
DOI: 10.1016/j.taap.2007.10.028
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12777
Kimura H, Yamamoto T, Sakai H, Sakai Y, Fujii T.
An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models
Lab Chip
2008
8(5):741-6
PubMed ID: 18432344
DOI: 10.1039/b717091b
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12778
Han Y, Chin Tan TM, Lim LY.
In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression
Toxicol Appl Pharmacol
2008
230(3):283-9
PubMed ID: 18417181
DOI: 10.1016/j.taap.2008.02.026
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12779
Fukumori S, Murata T, Takaai M, Tahara K, Taguchi M, Hashimoto Y.
The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells
Drug Metab Pharmacokinet
2008
23(5):373-8
PubMed ID: 18974615
DOI: 10.2133/dmpk.23.373
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12780
Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.
Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia
J Lipid Res
2008
49(4):763-72.
PubMed ID: 18180267
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12781
Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y.
The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption
Cell Microbiol
2008
10(2):355-64
PubMed ID: 17868282
DOI: 10.1111/j.1462-5822.2007.01048.x
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12785
Takaai M, Morishita H, Ishida K, Taguchi M, Hashimoto Y.
Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells
Eur J Pharmacol
2008
601(1-3):61-5
PubMed ID: 19013148
DOI: 10.1016/j.ejphar.2008.10.047
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12786
Kadowaki M, Sugihara N, Tagashira T, Terao K, Furuno K.
Presence or absence of a gallate moiety on catechins affects their cellular transport
J Pharm Pharmacol
2008
60(9):1189-95
PubMed ID: 18718123
DOI: 10.1211/jpp.60.9.0011
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12788
Shah AK, Kinoshita M, Kurihara H, Ohnishi M, Takahashi K.
Glycosylceramides obtain from the starfish Asterias amurensis Lütken
J Oleo Sci
2008
57(9):477-84
PubMed ID: 18685230
DOI: 10.5650/jos.57.477
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12791
Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.
Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity
Biol Pharm Bull
2008
31(10):1933-7
PubMed ID: 18827358
DOI: 10.1248/bpb.31.1933
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12796
Chono S, Takeda E, Seki T, Morimoto K.
Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin
Int J Pharm
2008
347(1-2):71-8
PubMed ID: 17689212
DOI: 10.1016/j.ijpharm.2007.06.037
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8807
Katsube T, Tsuji H, Onoda M.
Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.
Biochim. Biophys. Acta
2007
1773:794-803
PubMed ID: 17451824
DOI: 10.1016/j.bbamcr.2007.03.002
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8846
Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.
Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.
Br. J. Pharmacol.
2007
150:209-19
PubMed ID: 17160010
DOI: 10.1038/sj.bjp.0706972
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3580
Ito T, Maki N, Hazeki O, Sasaki K, Nekooki M.
Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines.
Cell Biol Int
2007
31(12):1518-24
PubMed ID: 17719804
DOI: 10.1016/j.cellbi.2007.06.017
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3692
Arimochi J, Ohashi-Kobayashi A, Maeda M.
Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.
Biol Pharm Bull
2007
30(4):648-54
PubMed ID: 17409496
DOI: 10.1248/bpb.30.648
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3599
Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R.
Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.
Biosci Biotechnol Biochem
2007
71(8):1886-95
PubMed ID: 17690481
DOI: 10.1271/bbb.70109
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9059
Y-C Jung, E Mizuki, T Akao, J-C Côté
Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells
J Appl Microbiol
2007
103 (1), 65-79
PubMed ID: 17584453
DOI: 10.1111/j.1365-2672.2006.03260.x
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9062
Hitoshi HORIE, Yuichi FUJII, Kouji KATABAMI, Masanori IWAMA, Akira YAMADA
Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype
Journal of Traditional Medicines
2007
24: 156-163
DOI: 10.11339/jtm.24.156
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11676
Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, Tomohiro Hosoi
Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid
Biosci Biotechnol Biochem
2007
71(10):2428-34
PubMed ID: 17928716
DOI: 10.1271/bbb.70172
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12815
Satoko GUNJI, Joko SANTOSO, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide
Food Science and Technology Research
2007
13:275-279
DOI: 10.3136/fstr.13.27
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12799
Oda M, Fujimoto K, Kobayashi M, Saitoh H.
Bacampicillin uptake is shared with thiamine in Caco-2 cells
Biol Pharm Bull
2007
30(7):1344-9
PubMed ID: 17603179
DOI: 10.1248/bpb.30.1344
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12800
Sugihara N, Toyama K, Okamoto T, Kadowaki M, Terao K, Furuno K.
Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach
Toxicol In Vitro
2007
21(5):827-34
PubMed ID: 17408918
DOI: 10.1016/j.tiv.2007.02.005
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12801
Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers
Biol Pharm Bull . 2007 Nov;30(11):2167-72
2007
30(11):2167-72
PubMed ID: 17978494
DOI: 10.1248/bpb.30.2167
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12802
Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M.
TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation
World J Gastroenterol
2007
13(19):2717-21
PubMed ID: 17569141
DOI: 10.3748/wjg.v13.i19.2717
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12804
Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y.
Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2007
30(10):1930-3
PubMed ID: 17917264
DOI: 10.1248/bpb.30.1930
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12805
Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.
Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro
Am J Physiol Gastrointest Liver Physiol
2007
292(3):G923-9
PubMed ID: 17170030
DOI: 10.1152/ajpgi.00145.2006
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12807
Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E.
Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells
J Biol Chem
2007
282(10):7742-52
PubMed ID: 17204466
DOI: 10.1074/jbc.M611382200
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12810
Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki
Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats
Asian-Australasian Journal of Animal Sciences
2007
20(7): 1120-1126
DOI: 10.5713/ajas.2007.1120
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12811
Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T.
Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport
J Pharm Pharmacol
2007
59(10):1383-7
PubMed ID: 17910813
DOI: 10.1211/jpp.59.10.0008
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3432
Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro
In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.
Drug Metab Dispos
2006
34:369-74
PubMed ID: 16326817
DOI: 10.1124/dmd.105.006213
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3404
Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao
Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.
J Pharm Sci
2006
95:552-60
PubMed ID: 16419049
DOI: 10.1002/jps.20563
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8890
Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.
Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.
Biol. Pharm. Bull.
2006
29:535-8
PubMed ID: 16508161
DOI: 10.1248/bpb.29.535
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12816
Han Y, Tan TM, Lim LY.
Effects of capsaicin on P-gp function and expression in Caco-2 cells
Biochem Pharmacol
2006
71(12):1727-34
PubMed ID: 16674925
DOI: 10.1016/j.bcp.2006.03.024
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12817
Watanabe K, Jinriki T, Sato J.
Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2
Biol Pharm Bull
2006
29(1):90-5
PubMed ID: 16394517
DOI: 10.1248/bpb.29.90
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12818
Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T.
Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells
Biosci Biotechnol Biochem
2006
70(12):2906-12
PubMed ID: 17151482
DOI: 10.1271/bbb.60318
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12819
Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K.
Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers
J Pharm Sci
2006
95(6):1393-401
PubMed ID: 16625653
DOI: 10.1002/jps.20616
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12820
M Gueimonde et al
Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli
Food Research International
2006
39:467-471
DOI: 10.1016/j.foodres.2005.10.003
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12821
Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.
Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer
Toxicology
2006
223(1-2):156-65
PubMed ID: 16647797
DOI: 10.1016/j.tox.2006.03.011
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12822
Ishida K, Takaai M, Hashimoto Y.
Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells
Biol Pharm Bull
2006
29(3):522-6
PubMed ID: 16508158
DOI: 10.1248/bpb.29.522
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12823
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells
Food Science and Technology Research
2006
12:290-294
DOI: 10.3136/fstr.12.290
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12824
Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.
Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
J Gastroenterol
2006
2006 Feb;41(2):140-50
PubMed ID: 16568373
DOI: 10.1007/s00535-005-1733-6
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12825
Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.
Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
Hepatol Res
2006
35(3):152-62
PubMed ID: 16707273
DOI: 10.1016/j.hepres.2006.03.011
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12826
Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.
Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli
Protein Expr Purif
2006
47(1):144-51
PubMed ID: 16307894
DOI: 10.1016/j.pep.2005.10.011
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12827
Makoto KIMURA, Kuninaga DANNO, Hisako YASUI
Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk
Bioscience and Microflora
2006
25:147-155
DOI: 10.12938/bifidus.25.147
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12828
Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.
Determination of p-glycoprotein ATPase activity using luciferase
Biol Pharm Bull
2006
29(3):560-4
PubMed ID: 16508168
DOI: 10.1248/bpb.29.560
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3026
Aiba T, Susa M, Fukumori S, Hashimoto Y
The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180
Drug Metab Pharmacokinet
2005
20:268-274
PubMed ID: 16141606
DOI: 10.2133/dmpk.20.268
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3025
Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya
Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.
Biol Pharm Bull
2005
28:114-9
PubMed ID: 15635174
DOI: 10.1248/bpb.28.114
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3072
Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru
Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.
Biosci Biotechnol Biochem
2005
69:202-5
PubMed ID: 15665486
DOI: 10.1271/bbb.69.202
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3300
Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.
Biol Pharm Bull
2005
28:527-30
PubMed ID: 15744083
DOI: 10.1248/bpb.28.527
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3155
Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu
Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.
Int J Vitam Nutr Res
2005
75:39-46
PubMed ID: 15830920
DOI: 10.1024/0300-9831.75.1.39
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3164
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Biochemistry
2005
44:6343-9
PubMed ID: 15835923
DOI: 10.1021/bi047606a
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3270
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
Hepatol. Res.
2005
33:198-205
PubMed ID: 16198622
DOI: 10.1016/j.hepres.2005.08.005
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9134
Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.
CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS
Chiang Mai Med Bull
2005
44:21-28
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9048
Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye
Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines
J Agric Food Chem
2005
53 (16), 6313-8
PubMed ID: 16076112
DOI: 10.1021/jf0506129
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12832
Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI
Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2
Food Science and Technology Research
2005
11:202-206
DOI: 10.3136/fstr.11.202
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12833
Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.
The effects of coffee on conjugation reactions in human colon carcinoma cells
Biol Pharm Bull
2005
28(2):271-4
PubMed ID: 15684482
DOI: 10.1248/bpb.28.271
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12835
Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.
Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
Biochim Biophys Acta
2005
1732(1-3):43-52
PubMed ID: 16380173
DOI: 10.1016/j.bbaexp.2005.11.003
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2720
Saegusa S, Totsuka M, Kaminogawa S, Hosoi T
Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.
FEMS Immunol Med Microbiol
2004
41:227-35
PubMed ID: 15196572
DOI: 10.1016/j.femsim.2004.03.006
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2736
Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi
Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.
Eur J Pharm Sci
2004
21:87-95
PubMed ID: 14706815
DOI: 10.1016/j.ejps.2003.10.002
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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2735
Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi
Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.
Biol Pharm Bull
2004
27:559-63
PubMed ID: 15056866
DOI: 10.1248/bpb.27.559
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3199
Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji
Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.
Am J Physiol Cell Physiol
2004
287:C1404-11
PubMed ID: 15229109
DOI: 10.1152/ajpcell.00471.2003
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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3094
Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Cancer Res
2004
64:6410-5
PubMed ID: 15374948
DOI: 10.1158/0008-5472.CAN-04-1543
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2708
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.
Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.
J. Exp. Clin. Cancer Res.
2004
23:69-75
PubMed ID: 15149153
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3066
Aida K. et al.
Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.
J Oleo Sci.
2004
53:503-510
DOI: 10.5650/jos.53.503
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4723
Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.
Oncol Res
2004
14(9):407-14
PubMed ID: 15490972
DOI: 10.3727/0965040041791464
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12839
Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.
Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells
Biosci Biotechnol Biochem
2004
68(12):2541-6
PubMed ID: 15618625
DOI: 10.1271/bbb.68.2541
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12840
Shigeaki Okamura, Hiro-omi Tamura
Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2
Journal of Health Science
2004
50:189-192
DOI: 10.1248/jhs.50.189
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
DOI: 10.1177/026119290403201s15
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12843
Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.
Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids
Cell Transplant
2004
13(4):463-73
PubMed ID: 15468688
DOI: 10.3727/000000004783983882
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
DOI: 10.1016/j.bcp.2003.11.002
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2645
Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi
Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).
Int J Food Microbiol
2003
82:255-64
PubMed ID: 12593928
DOI: 10.1016/s0168-1605(02)00311-2
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3042
Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo
An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.
Biochim Biophys Acta
2003
1612:186-94
PubMed ID: 12787937
DOI: 10.1016/s0005-2736(03)00130-5
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18851
Sugawara T, Kinoshita M, Ohnishi M, Nagata J, Saito M.
Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cells
J Nutr
2003
133(9):2777-82
PubMed ID: 12949364
DOI: 10.1093/jn/133.9.2777
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3791
Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
Pharm Res
2003
20(2):324-7
PubMed ID: 12636175
DOI: 10.1023/a:1022251910820
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3792
Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.
Growth promoting effect of thioredoxin on intestinal epithelial cells.
Dig Dis Sci
2003
48(2):379-85
PubMed ID: 12643619
DOI: 10.1023/a:1021952132241
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
DOI: 10.1007/s10047-003-0238-4
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3796
Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.
Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.
Int J Cancer
2003
107(1):53-9
PubMed ID: 12925956
DOI: 10.1002/ijc.11348
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2734
Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:885-90
PubMed ID: 12132663
DOI: 10.1248/bpb.25.885
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2629
Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji
Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.
Biochem Biophys Res Commun
2002
296:625-30
PubMed ID: 12176027
DOI: 10.1016/s0006-291x(02)00853-7
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2633
Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi
Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.
Biol Pharm Bull
2002
25:1345-50
PubMed ID: 12392092
DOI: 10.1248/bpb.25.1345
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3750
Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.
Microbiol Immunol
2002
46(4):293-7
PubMed ID: 12061632
DOI: 10.1111/j.1348-0421.2002.tb02698.x
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3779
Yamauchi K, Komatsu T, Kulkarni AD, Ohmori Y, Minami H, Ushiyama Y, Nakayama M, Yamamoto S.
Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis.
Nutrition
2002
18(4):329-33
PubMed ID: 11934546
DOI: 10.1016/s0899-9007(01)00788-2
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3781
Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ.
Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells.
Biol Pharm Bull
2002
25(3):393-6
PubMed ID: 11913542
DOI: 10.1248/bpb.25.393
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3783
Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.
Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.
J Gastroenterol
2002
37(11):896-904
PubMed ID: 12483244
DOI: 10.1007/s005350200151
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16630
Nakamura T, Sakaeda T, Ohmoto N, Tamura T, Aoyama N, Shirakawa T, Kamigaki T, Nakamura T, Kim KI, Kim SR, Kuroda Y, Matsuo M, Kasuga M, Okumura K.
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas
Drug Metab Dispos
2002
30(1):4-6
PubMed ID: 11744604
DOI: 10.1124/dmd.30.1.4
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2554
Tamura, H., and Matsui, M.
Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
J Health Science
2001
47:468-472
DOI: 10.1248/jhs.47.468
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2544
Todoriki K, Mukai T, Sato S, Toba T
Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.
J Appl Microbiol
2001
91:154-9
PubMed ID: 11442725
DOI: 10.1046/j.1365-2672.2001.01371.x
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2553
Isozaki T, Tamura H
Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2001
24:1076-8
PubMed ID: 11558573
DOI: 10.1248/bpb.24.1076
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2550
Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F
Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.
Biol Pharm Bull
2001
24:1258-62
PubMed ID: 11725959
DOI: 10.1248/bpb.24.1258
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3768
Takeuchi K, Mizuno M, Uesu T, Nasu J, Kawada M, Hori S, Okada H, Endo Y, Fujita T, Tsuji T.
Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway.
J Lab Clin Med
2001
138(3):186-92
PubMed ID: 11528371
DOI: 10.1067/mlc.2001.117405
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3771
Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.
DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Cancer Genet Cytogenet
2001
126(1):34-8
PubMed ID: 11343776
DOI: 10.1016/s0165-4608(00)00391-5
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3772
Ijichi H, Ikenoue T, Kato N, Mitsuno Y, Togo G, Kato J, Kanai F, Shiratori Y, Omata M.
Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.
Biochem Biophys Res Commun
2001
289(2):350-7
PubMed ID: 11716479
DOI: 10.1006/bbrc.2001.5988
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3774
Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S.
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.
Biochem Biophys Res Commun
2001
280(5):1216-23
PubMed ID: 11162657
DOI: 10.1006/bbrc.2001.4267
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16964
Ohishi K, Aiyama R, Hatano H, Yoshida Y, Wada Y, Yokoi W, Sawada H, Watanabe T, Yokokura T.
Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase
Chem Pharm Bull (Tokyo)
2001
49(7):830-9
PubMed ID: 11456087
DOI: 10.1248/cpb.49.830
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2551
Tamura H, Matsui M
Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:695-9
PubMed ID: 10864017
DOI: 10.1248/bpb.23.695
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2552
Satoh T, Matsui M, Tamura H
Sulfotransferases in a human colon carcinoma cell line, Caco-2.
Biol Pharm Bull
2000
23:810-4
PubMed ID: 10919357
DOI: 10.1248/bpb.23.810
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3780
Endo T, Kimura O, Saitoh H, Sakata M.
Secretory transport of cadmium through intestinal brush border membrane via H(+)-antiport.
Toxicology
2000
150(1-3):129-36
PubMed ID: 10996669
DOI: 10.1016/s0300-483x(00)00248-1
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3761
Nakayama A, Saitoh H, Oda M, Takada M, Aungst BJ.
Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system.
Eur J Pharm Sci
2000
11(4):317-24
PubMed ID: 11033075
DOI: 10.1016/s0928-0987(00)00113-5
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3763
Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.
Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.
Biochem Biophys Res Commun
2000
19;267(2):658-62
PubMed ID: 10631118
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3758
Miyata R, Iwabuchi K, Watanabe S, Sato N, Nagaoka I.
Short exposure of intestinal epithelial cells to TNF-alpha and histamine induces Mac-1-mediated neutrophil adhesion independent of protein synthesis.
J Leukoc Biol
1999
66(3):437-46
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Kanda T, Foucand L, Nakamura Y, Niot I, Besnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H
Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells
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1998
330:261-265
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Tsuji S, Kawano S, Sawaoka H, Takei Y, Kobayashi I, Nagano K, Fusamoto H, Kamada T.
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines
Prostaglandins Leukot Essent Fatty Acids
1996
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1430
Hayashi S, Watanabe J, Kawajiri K.
Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.
J Biochem
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PubMed ID: 1778977
DOI: 10.1093/oxfordjournals.jbchem.a123619
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