CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0988 : CACO-2]

1170 Fogh J, Wright, W C, Loveless, J D Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst 1977 58:209-14 PubMed ID: 833871 DOI: 10.1093/jnci/58.2.209

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19855 Kida R, Tsugane M, Suzuki H. Horizontal and vertical microchamber platforms for evaluation of the paracellular permeability of an epithelial cell monolayer Lab Chip 2024 24(3):572-583 PubMed ID: 38175144 DOI: 10.1039/d3lc00855j

19990 Kiriko Iida, Asuka Iwasa, Yuuki Amano, Koshu Okubo, Junichi Hirahashi, Hiroshi Kawakami Preventive effect of lactoferrin peptides on ulcerative colitis International Dairy Journal 2024 150:105832 DOI: 10.1016/j.idairyj.2023.105832

21644 Nonaka S, Okamoto R, Katsuta Y, Kanetsuki S, Nakanishi H. Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol. Biochem Biophys Res Commun 2024 707:149783 PubMed ID: 38493746 DOI: 10.1016/j.bbrc.2024.149783

21669 Miyasaka K, Takada R, Wu J, Takeda S, Manse Y, Morikawa T, Shimoda H. Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption. J Nat Med 2024 PubMed ID: 38587581 DOI: 10.1007/s11418-024-01791-5

21702 Ikuno Y, Tsujino H, Haga Y, Manabe S, Idehara W, Hokaku M, Asahara H, Higashisaka K, Tsutsumi Y. Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches. Ecotoxicol Environ Saf 2024 277:116346 PubMed ID: 38669869 DOI: 10.1016/j.ecoenv.2024.116346

21709 Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T. Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine. J Gastroenterol 2024 PubMed ID: 38695904 DOI: 10.1007/s00535-024-02104-z

21729 Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Niitsuma F, Kawahara T, Watanabe J, Tanaka S. Heat-killed Lactiplantibacillus plantarum Shinshu N-07 exerts antiobesity effects in western diet-induced obese mice. J Appl Microbiol 2024 PubMed ID: 38740521 DOI: 10.1093/jambio/lxae119

21747 Nagasawa M, Onuki M, Imoto N, Tanaka K, Tanaka R, Kawada M, Imato K, Iitani K, Tsuchido Y, Takeda N. Fabrication of 3D engineered intestinal tissue producing abundant mucus by air-liquid interface culture using paper-based dual-layer scaffold. Biofabrication 2024 PubMed ID: 38788705 DOI: 10.1088/1758-5090/ad504b

21748 Nakatani E, Sasai M, Miyazaki H, Tanaka S, Hirota T, Okura T. Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in Caco-2 Cells. J Agric Food Chem 2024 PubMed ID: 38789103 DOI: 10.1021/acs.jafc.4c00974

21790 Fujita S, Plianchaisuk A, Deguchi S, Ito H, Nao N, Wang L, Nasser H, Tamura T, Kimura I, Kashima Y, Suzuki R, Suzuki S, Kida I, Tsuda M, Oda Y, Hashimoto R, Watanabe Y, Uriu K, Yamasoba D, Guo Z, Hinay AA Jr, Kosugi Y, Chen L, Pan L, Kaku Y, Chu H, Donati F, Temmam S, Eloit M, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Suzuki Y, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Ikeda T, Tanaka S, Matsuno K, Fukuhara T, Takayama K, Sato K. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236. EBioMedicine 2024 104:105181 PubMed ID: 38838469 DOI: 10.1016/j.ebiom.2024.105181

21877 Tanabe T, Tsukamoto M, Shioda M, Nagaoka K, Funahashi T. Expression regulation of type III secretion system 2 in Vibrio parahaemolyticus by catabolite activator protein. FEMS Microbiol Lett 2024 PubMed ID: 39054297 DOI: 10.1093/femsle/fnae054

21961 Koizumi A, Kaji K, Nishimura N, Asada S, Matsuda T, Tanaka M, Yorioka N, Tsuji Y, Kitagawa K, Sato S, Namisaki T, Akahane T, Yoshiji H. Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease. World J Gastroenterol 2024 30(28):3428-3446 PubMed ID: 39091710 DOI: 10.3748/wjg.v30.i28.3428

21964 Kurosu J, Sakamaki T, Kanai K, Morishita K, Sumaru K, Tsutsumi J. Spatiotemporal dynamics of microscopic biological barrier visualized by electric-double-layer modulation imaging. Biosens Bioelectron 2024 266:116721 PubMed ID: 39226753 DOI: 10.1016/j.bios.2024.116721

21987 Lina Yonekura, Haruka Hisada, Jittipon Intravichakul Human α-glucosidase inhibition and phytochemical profile of natural and shinzuke treated olives: implications from the processing method Food Production, Processing and Nutrition 2024 6 DOI: 10.1186/s43014-024-00227-7

22092 Itoh T, Miyazono D, Sugata H, Mori C, Takahata M. Anti-inflammatory effects of heat-killed Lactiplantibacillus argentoratensis BBLB001 on a gut inflammation co-culture cell model and dextran sulfate sodium-induced colitis mouse model. Int Immunopharmacol 2024 143(Pt 2):113408 PubMed ID: 39461236 DOI: 10.1016/j.intimp.2024.113408

22153 Takizawa Y, Furuya T, Uno M, Ohashi R, Mimura E, Kurita T, Nakajima T. Specific inhibitory effects of exogenous d-Aspartate on the proliferation of intestinal epithelial cells. Biochem Biophys Res Commun 2024 734:150659 PubMed ID: 39245027 DOI: 10.1016/j.bbrc.2024.150659

17773 Watanabe K, Negoro R, Fujita T. 5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells Biochem Biophys Res Commun 2023 664:94-99 PubMed ID: 37141642 DOI: 10.1016/j.bbrc.2023.04.077

17774 Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H. Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells Biosci Biotechnol Biochem 2023 zbad030 PubMed ID: 36941128 DOI: 10.1093/bbb/zbad030

17775 Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells J. Excipients and Food Chem 2023 14:22-32

17776 Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H. Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels BMC Cancer 2023 23(1):356 PubMed ID: 37072777 DOI: 10.1186/s12885-023-10845-y

17778 Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα Drug Metabolism and Pharmacokinetics 2023 DOI: 10.1016/j.dmpk.2023.100512

17779 Sansawat, A., Ratanacoon, M. and Nitteranon, V. Antioxidative, anti-inflammatory, antibacterial, and anti- adhesive activities of different solvent extracts from various parts of Basella rubra L. International Journal of Agricultural Technology 2023 19(2):655-668

17780 Zhu Q, Iwai R, Okaguchi T, Shirasaka Y, Tamai I. Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT Food Funct 2023 May 2 PubMed ID: 37129213 DOI: 10.1039/d3fo00510k

19578 Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound Molecules 2023 28(11):4549 PubMed ID: 37299024 DOI: 10.3390/molecules28114549

19634 Tomii A, Higa M, Naito K, Kurata K, Kobayashi J, Takei C, Yuasa K, Koto Y, Shimizu H. Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cells Biosci Biotechnol Biochem 2023 87(8):839-849 PubMed ID: 37147026 DOI: 10.1093/bbb/zbad055

19662 Yusuke Takizawa, Naruya Kunii, Takanori Nakajima Comparison of pharmaceutical characteristics and membrane permeability of truvada combination tablets and its generic drugs Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 2023 19 DOI: 10.1177/174113432311916

19704 Orita T, Chogahara S, Okuda M, Sakao K, Miyata T, Hou DX. Extraction Efficiency and Alpha-Glucosidase Inhibitory Activities of Green Tea Catechins by Different Infusion Methods Foods 2023 12(13):2611. PubMed ID: 37444349 DOI: 10.3390/foods12132611

19835 Sugihara N, Okada Y, Tomioka A, Ito S, Tanemoto R, Nishii S, Mizoguchi A, Inaba K, Hanawa Y, Horiuchi K, Wada A, Akita Y, Higashiyama M, Kurihara C, Komoto S, Tomita K, Hokari R. Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome Gut Liver 2023 Jun 9 PubMed ID: 37291901 DOI: 10.5009/gnl220100

19840 Alghurabi H, Jassim Muhammad H, Tagami T, Ogawa K, Ozeki T. Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid Int J Pharm 2023 648:123597. PubMed ID: 37952559 DOI: 10.1016/j.ijpharm.2023.123597

19883 Maruyama M, Yoshikata M, Sakaguchi M, Wakushima S, Higaki K. Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs Int J Pharm 2023 633:122617 PubMed ID: 36657552 DOI: 10.1016/j.ijpharm.2023.122617

19917 Ishioka K, Miyazaki N, Nishiyama K, Suzutani T. Characterization of Lactococcus lactis 11/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic Microorganisms 2023 11(12):2949 PubMed ID: 38138093 DOI: 10.3390/microorganisms11122949

19918 Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I. Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation Toxicol Mech Methods 2023 33(9):741-754 PubMed ID: 37496379 DOI: 10.1080/15376516.2023.2238061

19925 Mukai H, Takanashi M, Ogawara KI, Maruyama M, Higaki K. Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers J Pharm Sci 2023 S0022-3549(23)00486-0 PubMed ID: 37984697 DOI: 10.1016/j.xphs.2023.11.010

19943 Koyama Y, Fujihara S, Chiyo T, Matsui T, Hamaya S, Fujita K, Tani J, Morishita A, Kobara H, Ono M, Iwama H, Masaki T. Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer In Vivo 2023 37(5):1980-1990 PubMed ID: 37652512 DOI: 10.21873/invivo.13295

19959 Tamura S, Tazawa H, Hori N, Li Y, Yamada M, Kikuchi S, Kuroda S, Urata Y, Kagawa S, Fujiwara T. p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells PLoS One 2023 18(11):e0294491 PubMed ID: 37972012 DOI: 10.1371/journal.pone.0294491

13874 Yamada N, Negoro R, Watanabe K, Fujita T. Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system Drug Metab Pharmacokinet 2023 50:100497. PubMed ID: 37037169 DOI: 10.1016/j.dmpk.2023.100497

21020 Kudo K, Kobayashi T, Kasai K, Nozaka H, Nakamura T. Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α. Biochem Biophys Res Commun 2023 642:185-191 PubMed ID: 36586186 DOI: 10.1016/j.bbrc.2022.12.051

21021 Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T. Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p. Biochim Biophys Acta Mol Cell Res 2023 1870(2):119404 PubMed ID: 36535369 DOI: 10.1016/j.bbamcr.2022.119404

21182 Tsubaki M, Takeda T, Matsuda T, Kishimoto K, Takefuji H, Taniwaki Y, Ueda M, Hoshida T, Tanabe K, Nishida S. Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy. Cancer Cell Int 2023 23(1):73 PubMed ID: 37069612 DOI: 10.1186/s12935-023-02884-z

21203 Kuriya K, Goto S, Kobayashi E, Nishio M, Nakamura M, Umekawa H. Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols. Mol Biol Rep 2023 PubMed ID: 37160631 DOI: 10.1007/s11033-023-08481-7

21281 Lyu M, Bai Y, Orihara K, Miyanaga K, Yamamoto N. GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions. Microorganisms 2023 11(6) PubMed ID: 37374895 DOI: 10.3390/microorganisms11061393

21285 Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E. Prohaptoglobin is a possible prognostic biomarker for colorectal cancer. Biochem Biophys Res Commun 2023 672:72-80 PubMed ID: 37343317 DOI: 10.1016/j.bbrc.2023.06.017

21307 Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E. Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer. Ann Surg Oncol 2023 PubMed ID: 37407874 DOI: 10.1245/s10434-023-13779-8

21310 Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T. Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis. J Gastroenterol 2023 PubMed ID: 37410250 DOI: 10.1007/s00535-023-02016-4

21358 Yamaguchi R, Kanie Y, Kazamaki T, Kanie O, Shimizu Y. Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells. Carbohydr Res 2023 532:108921 PubMed ID: 37562111 DOI: 10.1016/j.carres.2023.108921

21419 Shibamoto A, Kaji K, Nishimura N, Kubo T, Iwai S, Tomooka F, Suzuki J, Tsuji Y, Fujinaga Y, Kawaratani H, Namisaki T, Akahane T, Yoshiji H. Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin. J Nutr Biochem 2023 109450 PubMed ID: 37777163 DOI: 10.1016/j.jnutbio.2023.109450

21424 Kataoka M, Kitazawa M, Nakamura S, Koyama M, Yamamoto Y, Miyazaki S, Hondo N, Tanaka H, Soejima Y. Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment. Anticancer Res 2023 43(10):4341-4348 PubMed ID: 37772552 DOI: 10.21873/anticanres.16629

21445 Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M. Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability. Pharmaceutics 2023 15(9) PubMed ID: 37765306 DOI: 10.3390/pharmaceutics15092338

21455 Hiranphinyophat S, Hiraoka T, Kobayashi M, Fujii S, Kishida A, Tanabe T, Kimura T, Yamamoto M. Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies. Langmuir 2023 PubMed ID: 37882450 DOI: 10.1021/acs.langmuir.3c01858

21494 Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H. The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine. Biol Pharm Bull 2023 46(12):1745-1752 PubMed ID: 38044133 DOI: 10.1248/bpb.b23-00479

21521 Kiba Y, Tanikawa T, Hayashi T, Kamauchi H, Seki T, Suzuki R, Kitamura M. Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains. Biomed Pharmacother 2023 169:115940 PubMed ID: 38007936 DOI: 10.1016/j.biopha.2023.115940

17506 Hashizume J, Sato K, Nakagawa H, Harasawa H, Honda T, Kodama Y. Examination of the Effect of Proton Pump Inhibitors on the Anticancer Activity of Oxaliplatin Cancer Diagn Progn 2022 2(6):620-626 PubMed ID: 36340458 DOI: 10.21873/cdp.10151

17564 Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells Journal of Applied Pharmaceutical Science 2022 147-159 DOI: 10.7324/japs.2022.120715

17586 Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, Yamaji R. Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide J Agric Food Chem 2022 70(49):15499-15508 PubMed ID: 36458736 DOI: 10.1021/acs.jafc.2c06791

14784 Ariumi Y. Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection J Virol 2022 96(6):e0000222 PubMed ID: 35107372 DOI: 10.1128/jvi.00002-22

15564 Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T. Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system Arch Toxicol 2022 Oct 16 PubMed ID: 34654938 DOI: 10.1007/s00204-021-03175-0

20541 Shinji S, Shichi Y, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Yonaga K, Iwai T, Takeda K, Ueda K, Kuriyama S, Miyasaka T, Ueda Y, Sasaki N, Takahashi K, Ohashi R, Ishiwata T, Arai T, Yoshida H. A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor J Nippon Med Sch 2022 89(4):368-376 PubMed ID: 35082206 DOI: 10.1272/jnms.JNMS.2022_89-402

16347 Naoki Murata, Saki Keitoku, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers Natural Product Communications 2022 17:1934578X2110704 DOI: 10.1177/1934578x211070415

16348 Inada A, Sawao A, Takahashi K, Oshima T. Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate J Food Sci 2022 87(3):1174-1183 PubMed ID: 35122241 DOI: 10.1111/1750-3841.16049

16349 Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S. PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells Oncol Lett 2022 23(4):106 PubMed ID: 35242234 DOI: 10.3892/ol.2022.13226

20603 Diao X, Yamada K, Shibata Y, Imada C. Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide. Mar Drugs 2022 20(2) PubMed ID: 35200617 DOI: 10.3390/md20020087

20610 Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H. TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition. Biochem Biophys Rep 2022 30:101239 PubMed ID: 35252596 DOI: 10.1016/j.bbrep.2022.101239

20640 Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A. Indigo plant leaf extract inhibits the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2. Exp Ther Med 2022 23(4):274 PubMed ID: 35251340 DOI: 10.3892/etm.2022.11200

20686 Enomoto M, Kaji K, Nishimura N, Fujimoto Y, Murata K, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H. Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis. Dig Liver Dis 2022 PubMed ID: 35514019 DOI: 10.1016/j.dld.2022.04.012

20699 Takahashi Y, Abe H, Koayama K, Koseki S. Modeling the invasion of human small intestinal epithelial-like cells by Salmonella enterica Typhimurium and Listeria monocytogenes using Bayesian inference. Lett Appl Microbiol 2022 PubMed ID: 35575530 DOI: 10.1111/lam.13738

16510 Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation Toxicology Reports 2022 9:937-944 PubMed ID: 35875256 DOI: 10.1016/j.toxrep.2022.04.019

20749 Takizawa Y, Nakamura R, Kurita T, Nakajima T. Lactose hydrate can increase the transcellular permeability of β-naphthol in rat jejunum and ileum. Mol Biol Rep 2022 PubMed ID: 35767107 DOI: 10.1007/s11033-022-07709-2

16737 Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells Scholars Academic Journal of Pharmacy 2022 11:60-66 DOI: 10.36347/sajp.2022.v11i04.002

16738 Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding BPB Reports 2022 5:66-69 DOI: 10.1248/bpbreports.5.3_66

16739 Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T. Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles J Biotechnol 2022 354:34-44 PubMed ID: 35724765 DOI: 10.1016/j.jbiotec.2022.06.006

16742 Kawahara T, Shimizu I, Tanaka Y, Tobita K, Tomokiyo M, Watanabe I. Lactobacillus crispatus Strain KT-11 S-Layer Protein Inhibits Rotavirus Infection Front Microbiol 2022 13:783879 PubMed ID: 35273580 DOI: 10.3389/fmicb.2022.783879

20798 Onuma S, Kinoshita S, Shimba S, Ozono K, Michigami T, Kawai M. The lack of Bmal1, a core clock gene, in the intestine decreases glucose absorption in mice. Endocrinology 2022 PubMed ID: 35904419 DOI: 10.1210/endocr/bqac119

20829 Sakakibara Y, Kojima A, Asai Y, Nadai M, Katoh M. Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid. Biopharm Drug Dispos 2022 PubMed ID: 36000181 DOI: 10.1002/bdd.2328

20956 Satow R, Suzuki Y, Asada S, Ota S, Idogawa M, Kubota S, Ikeo N, Yoneda A, Fukami K. Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells. iScience 2022 25(12):105501 PubMed ID: 36404918 DOI: 10.1016/j.isci.2022.105501

20966 Akino S, Yasujima T, Yamashiro T, Yuasa H. Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter. Life Sci Alliance 2022 6(2) PubMed ID: 36456177 DOI: 10.26508/lsa.202201629

17777 Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima The influence of 4-methylimidazole on the gastrointestinal epithelial cells J. Excipients and Food Chem 2021 12:4-15

12864 Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M. Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy Biol Trace Elem Res 2021 199(9):3272-3286 PubMed ID: 33236292 DOI: 10.1007/s12011-020-02463-7

20031 Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K. Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin. Biol Pharm Bull 2021 44(2):275-278 PubMed ID: 33518681 DOI: 10.1248/bpb.b20-00644

13512 Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I. Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase mBio 2021 12(1):e01974-20 PubMed ID: 33563838 DOI: 10.1128/mBio.01974-20

13556 Zhu Q, Komori H, Imamura R, Tamai I. A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT J Pharm Sci 2021 110(3):1392-1400 PubMed ID: 33278408 DOI: 10.1016/j.xphs.2020.11.030

20064 Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S. Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation. Eur J Pharmacol 2021 898:173957 PubMed ID: 33662352 DOI: 10.1016/j.ejphar.2021.173957

20066 Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y. Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph. Lipids Health Dis 2021 20(1):24 PubMed ID: 33648494 DOI: 10.1186/s12944-021-01448-2

20080 Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T. Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells. Int J Environ Res Public Health 2021 18(4) PubMed ID: 33671655 DOI: 10.3390/ijerph18042126

20149 Igarashi F, Nakagawa T, Shinohara Y, Tachibana T. Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment. Pharm Res 2021 Pharm Res PubMed ID: 34009624 DOI: 10.1007/s11095-021-03054-4

14514 Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M. An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement PLoS One 2021 16(6):e0253066 PubMed ID: 34115818 DOI: 10.1371/journal.pone.0253066

14782 Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A. MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Sci Rep 2021 11(1):5376 PubMed ID: 33686154 DOI: 10.1038/s41598-021-84882-7

14786 Sasaki M, Uemura K, Sato A, Toba S, Sanaki T, Maenaka K, Hall WW, Orba Y, Sawa H. SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells PLoS Pathog 2021 17(1):e1009233 PubMed ID: 33476327 DOI: 10.1371/journal.ppat.1009233

20226 Chowdhury MMI, Tomii A, Ishii K, Tahara M, Hitsuda Y, Koto Y, Kurata K, Yuasa K, Nishimura K, Shimizu H. TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells. Biosci Biotechnol Biochem 2021 PubMed ID: 34245564 DOI: 10.1093/bbb/zbab128

15106 Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N. Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted fr Food Chem 2021 360:129822 PubMed ID: 33984564 DOI: 10.1016/j.foodchem.2021.129822

15149 Gen Toshima, Takanobu Kiuchi, Yuka Iwama, Haruna Ohrui, Fumiko Kimura, Shiho Nakagawa, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata, Junichiro Takahashi Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki) Journal of Biological Macromolecules 2021 21:33-44 DOI: 10.14533/jbm.21.33

20270 Nguma E, Yamashita S, Kumagai K, Otoki Y, Yamamoto A, Eitsuka T, Nakagawa K, Miyazawa T, Kinoshita M. Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress. ACS Omega 2021 6(4):3140-3148 PubMed ID: 33553930 DOI: 10.1021/acsomega.0c05545

20293 Arai M, Komori H, Fujita D, Tamai I. Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo. Pharm Res 2021 38(3):523-530 PubMed ID: 33723795 DOI: 10.1007/s11095-021-03018-8

20300 Kitazawa M, Miyagawa Y, Koyama M, Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu D, Takeoka M, Soejima Y. Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL. Mol Clin Oncol 2021 15(1):148 PubMed ID: 34094546 DOI: 10.3892/mco.2021.2310

15288 Akihiro Nishiguchi, Tetsushi Taguchi Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis Advanced Functional Materials 2021 2100548 DOI: 10.1002/adfm.202100548

15412 Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K. Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer Cancer Sci 2021 112(8):3173-3189 PubMed ID: 34008277 DOI: 10.1111/cas.14969

20369 Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K. Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells. Mol Ther Nucleic Acids 2021 PubMed ID: 34692233 DOI: 10.1016/j.omtn.2021.10.016

20384 Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T. Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia. Mol Pharm 2021 PubMed ID: 34734526 DOI: 10.1021/acs.molpharmaceut.1c00490

15758 Suzuki T, Nagata M, Kagawa N, Takano S, Nahrowi, Nomura J. Anti-Obesity Effects of Matoa ( Pometia pinnata) Fruit Peel Powder in High-Fat Diet-Fed Rats Molecules 2021 26(21):6733 PubMed ID: 34771142 DOI: 10.3390/molecules26216733

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

15879 Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K. 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2 iScience 2021 24(10):103120 PubMed ID: 34541466 DOI: 10.1016/j.isci.2021.103120

15881 Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Nat Commun 2021 12(1):6602 PubMed ID: 34782627 DOI: 10.1038/s41467-021-26910-8

20468 Choeisoongnern T, Sirilun S, Waditee-Sirisattha R, Pintha K, Peerajan S, Chaiyasut C. Potential Probiotic Enterococcus faecium OV3-6 and Its Bioactive Peptide as Alternative Bio-Preservation. Foods 2021 10(10) PubMed ID: 34681312 DOI: 10.3390/foods10102264

16102 Arung ET, Ramadhan R, Khairunnisa B, Amen Y, Matsumoto M, Nagata M, Kusuma IW, Paramita S, Sukemi, Yadi, Tandirogang N, Takemoto N, Syafrizal, Kim YU, Shimizu K. Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines Saudi J Biol Sci 2021 ;28(12):7182-7189 PubMed ID: 34867021 DOI: 10.1016/j.sjbs.2021.08.017

16123 Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M. Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation Front Oncol9 2021 11:70593 PubMed ID: 34595111 DOI: 10.3389/fonc.2021.705939

16137 Takashima Y, Ishikawa K, Miyawaki R, Ogawa M, Ishii T, Misaka T, Kobayashi S. Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity J Agric Food Chem 2021 69(33):9585-9596 PubMed ID: 34346218 DOI: 10.1021/acs.jafc.1c03483

16292 Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H. Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity World J Gastroenterol 2021 27(48):8323-8342 PubMed ID: 35068872 DOI: 10.3748/wjg.v27.i48.8323

16367 Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A. Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells Chem Biol Interact 2021 348:109634 PubMed ID: 34506768 DOI: 10.1016/j.cbi.2021.109634

16368 Komori H, Fujita D, Shirasaki Y, Zhu Q, Iwamoto Y, Nakanishi T, Nakajima M, Tamai I. MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-Transporting Peptide 2B1/ SLCO2B1 in Caco-2 Cells Drug Metab Dispos 2021 49(9):803-809 PubMed ID: 34162689 DOI: 10.1124/dmd.121.000380

16369 Abdelbasset Boubakri, Hanen Najjaa, Hanane Maghrebi, Abdelkarim Ben Arfa, Marcos Antonio Das Neves, Hiroko Isoda, Mitsutoshi Nakajima, Mohamed Neffati Effect of freeze‐drying on the antioxidant and the cytotoxic properties of Allium roseum L. and its application in stabilizing food emulsions Journal of Food Processing and Preservation 2021 45 DOI: 10.1111/jfpp.15389

16371 Nashimoto Y, Abe M, Fujii R, Taira N, Ida H, Takahashi Y, Ino K, Ramon-Azcon J, Shiku H. Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies Adv Healthc Mater 2021 10(21):e2101186 PubMed ID: 34409770 DOI: 10.1002/adhm.202101186

16373 Ito S, Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T. Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing Mater Sci Eng C Mater Biol Appl 2021 123:111993 PubMed ID: 33812615 DOI: 10.1016/j.msec.2021.111993

16728 YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells Biodiversitas Journal of Biological Diversity 2021 DOI: 10.13057/biodiv/d220412

11781 Tachibana K, Kondoh M. A Method to Prepare Claudin-Modulating Recombinant Proteins. Methods Mol. Biol 2020 2109:251-260 PubMed ID: 31471875 DOI: 10.1007/7651_2019_258

11784 Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H. α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation. J. Cell. Biochem 2020 121(2):1238-1249 PubMed ID: 31478242 DOI: 10.1002/jcb.29357

11981 Kawahara T, Fujii K, Nakajima K, Fujii R, Inagaki S, Hara K, Yasui H. Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells. Planta Med. 2020 PubMed ID: 31896136 DOI: 10.1055/a-1078-7860

12099 Meparambu Prabhakaran D, Ramamurthy T, Thomas S. Genetic and virulence characterisation of Vibrio parahaemolyticus isolated from Indian coast. BMC Microbiol. 2020 PubMed ID: 32293257 DOI: 10.1186/s12866-020-01746-2

13047 Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem 2020 PubMed ID: 32616184 DOI: 10.1016/j.bmc.2020.115562

13091 Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y. Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds. Carbohydr Polym 2020 PubMed ID: 32829826 DOI: 10.1016/j.carbpol.2020.116698

13136 Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S. 10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses. Biol Pharm Bull 2020 PubMed ID: 32741940 DOI: 10.1248/bpb.b20-00101

13162 Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M. Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model. J Oleo Sci 2020 PubMed ID: 32788522 DOI: 10.5650/jos.ess20105

13201 Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y. Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells. Int J Oncol 2020 PubMed ID: 32901840 DOI: 10.3892/ijo.2020.5117

13211 Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T. Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells. Biochem Biophys Rep 2020 PubMed ID: 32964147 DOI: 10.1016/j.bbrep.2020.100807

13234 Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K. Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells. Biochem Biophys Res Commun 2020 PubMed ID: 32977947 DOI: 10.1016/j.bbrc.2020.09.007

13252 Yamashiro T, Yasujima T, Said HM, Yuasa H. pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates. J Biol Chem 2020 PubMed ID: 33008889 DOI: 10.1074/jbc.RA120.013610

13289 Abe H, Koyama K, Koseki S. Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference. Appl Environ Microbiol 2020 PubMed ID: 33067190 DOI: 10.1128/AEM.01551-20

13316 Nagata Y, Yamamoto T, Kadowaki M. Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line. J Nutr Sci Vitaminol (Tokyo) 2020 PubMed ID: 33132350 DOI: 10.3177/jnsv.66.462

13449 Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph BMC 2020 DOI: 10.21203/rs.3.rs-88680/v1

13517 Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M. Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route J Membr Biol 2020 253(3):221-228 PubMed ID: 32328687 DOI: 10.1007/s00232-020-00118-1

13550 Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T. Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice Cancer Sci 2020 111(4):1193-1202 PubMed ID: 31997435 DOI: 10.1111/cas.14335

13574 Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M. Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro J Oleo Sci 2020 69(7):751-757 PubMed ID: 32612025 DOI: 10.5650/jos.ess20050

13620 Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N. Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats Front Pharmacol 2020 11:1277 PubMed ID: 32922296 DOI: 10.3389/fphar.2020.01277

13623 BaoruiLi et al Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1 Journal of Functional Foods 2020 75:104273 DOI: 10.1016/j.jff.2020.104273

13646 Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M. Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids Eur J Pharm Sci 2020 142:10514 PubMed ID: 31730802 DOI: 10.1016/j.ejps.2019.105144

13840 Nakajima T, Sasaki K, Yamamori A, Sakurai K, Miyata K, Watanabe T, Matsunaga YT. A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays Biomater Sci 2020 8(20):5615-5627 PubMed ID: 32945306 DOI: 10.1039/d0bm00763c

15260 Mu Y, Li J, Kang JH, Eto H, Zai K, Kishimura A, Hyodo F, Mori T, Katayama Y. A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation Biol Pharm Bull 2020 43(9):1413-1420 PubMed ID: 32879216 DOI: 10.1248/bpb.b20-00432

16823 Li Z, Zheng J, Luo X, Manabe Y, Hirata T, Sugawara T. Absorption and Tissue Distribution of Siphonaxanthin from Green Algae Mar Drugs 2020 18(6):291 PubMed ID: 32492769 DOI: 10.3390/md18060291

16825 Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N. Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria Vaccine 2020 38(17):3330-3338 PubMed ID: 32197922 DOI: 10.1016/j.vaccine.2020.02.084

17866 Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus Phytochemistry Letters 2019 32:10-14 DOI: 10.1016/j.phytol.2019.04.017

11283 Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N. NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells. FASEB J. 2019 PubMed ID: 30399323 DOI: 10.1096/fj.201801408R

11320 Hayashi I, Kanda S, Lamaningao P, Mishima N, Nishiyama T. Shared expression of mucin12 in Ascaris lumbricoides and the human small intestine. Mol. Biochem. Parasitol. 2019 PubMed ID: 30481538 DOI: 10.1016/j.molbiopara.2018.11.004

11386 Uchiyama H, Wada Y, Hatanaka Y, Hirata Y, Taniguchi M, Kadota K, Tozuka Y. Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer. J Pharm Sci 2019 PubMed ID: 30653971 DOI: 10.1016/j.xphs.2019.01.007

11426 Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30739789 DOI: 10.1016/j.bbrc.2019.01.122

11487 Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N. A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing. Sci Rep 2019 PubMed ID: 30894579 DOI: 10.1038/s41598-019-41151-y

11641 Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T. Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells. Biochim Biophys Acta Mol Cell Biol Lipids 2019 PubMed ID: 31351225 DOI: 10.1016/j.bbalip.2019.07.010

11702 Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose Natural Product Communications 2019 DOI: 10.1177/1934578X19883728

11825 Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T. Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin. Lipids 2019 PubMed ID: 31574565 DOI: 10.1002/lipd.12194

11871 Numata T, Sato-Numata K, Okada Y. Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels. Sci Rep 2019 PubMed ID: 31664151 DOI: 10.1038/s41598-019-52171-z

6882 Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H. Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor. Cancer Sci 2019 110(12):3708-3717 PubMed ID: 31648389 DOI: 10.1111/cas.14221

6921 Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A. Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells. Nutr Res 2019 72:92-104 PubMed ID: 31767206 DOI: 10.1016/j.nutres.2019.10.010

6940 Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S. Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data. Pharm Res 2019 37(1):13 PubMed ID: 31873817 DOI: 10.1007/s11095-019-2729-x

6942 Mahmoud Abdel-Hamid et al The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage International Dairy Journal 2019 91:1-8 DOI: 10.1016/j.idairyj.2018.12.007

6966 Matsuzaki T, Nakamura M, Nogita T, Sato A. Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells. Biol Pharm Bull 2019 42(6):989-995 PubMed ID: 31155596 DOI: 10.1248/bpb.b19-00011

9418 Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha iosci Microbiota Food Health 2019 38(1):11-22 PubMed ID: 30705798 DOI: 10.12938/bmfh.18-005

9414 Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2 CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin Mol Cell Biol 2019 39(16):e00073-19 PubMed ID: 31160493 DOI: 10.1128/MCB.00073-19

9810 Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves Plant Signal Behav 2019 14(10):e1644594 PubMed ID: 31342859 DOI: 10.1080/15592324.2019.1644594

10420 Sanae Yoshimoto, Keiko Okada, Osamu Hayashi Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier Functional Foods in Health and Disease 2019 9(7):466-483 DOI: 10.31989/ffhd.v9i7.611

10587 Selma Etteieb Jamila Tarhouni Hiroko Isoda Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures Water and Environment Journal 2019 33:4-13 DOI: 10.1111/wej.12361

10588 Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients Journal of Functional Foods 2019 55:352-361 DOI: 10.1016/j.jff.2019.02.026

11913 Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S. Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells. Cancers (Basel) 2019 PubMed ID: 31769426 DOI: 10.3390/cancers11121866

12013 Matsumoto A, Watanabe C, Murakami M. Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer. Drug Discov Ther 2019 PubMed ID: 31956233 DOI: 10.5582/ddt.2019.01090

12437 Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M. Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry PLoS One 2019 14(3):e0214000 PubMed ID: 30875389 DOI: 10.1371/journal.pone.0214000

12517 Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) Nat Prod Res 2019 33(2):189-195 PubMed ID: 29457741 DOI: 10.1080/14786419.2018.1440229

10543 Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M. Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers. Biochim. Biophys. Acta 2018 1860:428-433 PubMed ID: 28988777 DOI: 10.1016/j.bbamem.2017.10.003

10556 Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S. Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicol In Vitro 2018 46:284-293 PubMed ID: 29054700 DOI: 10.1016/j.tiv.2017.10.019

10580 Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K. Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites. Glycobiology 2018 28:21-31 PubMed ID: 29069492 DOI: 10.1093/glycob/cwx088

10656 Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M. Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells. Arch. Biochem. Biophys. 2018 638:58-65 PubMed ID: 29242061 DOI: 10.1016/j.abb.2017.12.010

10665 Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A. The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene 2018 37:1205-1219 PubMed ID: 29242607 DOI: 10.1038/s41388-017-0033-y

10681 Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J. Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis. Exp. Anim. 2018 67:201-218 PubMed ID: 29276215 DOI: 10.1538/expanim.17-0112

10794 Numata T, Sato-Numata K, Okada Y, Inoue R. Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR. J Nat Med 2018 72:694-705 PubMed ID: 29569221 DOI: 10.1007/s11418-018-1207-9

11102 Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K. A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling. Sci Rep 2018 8(1):9008 PubMed ID: 29899364 DOI: 10.1038/s41598-018-27408-y

11130 Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W. Probiotics in human gut microbiota can degrade host glycosaminoglycans. Sci Rep 2018 8(1):10674 PubMed ID: 30006634 DOI: 10.1038/s41598-018-28886-w

11260 Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I. Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells. Mol. Pharm. 2018 PubMed ID: 30359033 DOI: 10.1021/acs.molpharmaceut.8b00921

4174 Sakuta Y, Takehara I, Tsunoda KI, Sato K. Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance. Anal Sci 2018 PubMed ID: 29806615 DOI: 10.2116/analsci.18P141

4472 Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T. Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage. Inflamm. Res. 2018 67(11-12):975-984 PubMed ID: 30317465 DOI: 10.1007/s00011-018-1193-0

4473 Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N. Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo. Biol. Pharm. Bull. 2018 41(2):190-197 PubMed ID: 29386479 DOI: 10.1248/bpb.b17-00657

9492 Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma Oncotarget 2018 9(26):18480-18493 PubMed ID: 29719619 DOI: 10.18632/oncotarget.24883

9909 Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A. Role of CXC chemokine receptor type 4 as a lactoferrin receptor. Biochem. Cell Biol. 2017 95:57-63 PubMed ID: 28075616 DOI: 10.1139/bcb-2016-0039

10056 Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E. miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway. BMC Cancer 2017 17:33 PubMed ID: 28061765 DOI: 10.1186/s12885-016-3003-9

10091 Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y. Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure. Biochem. Biophys. Res. Commun. 2017 484:543-549 PubMed ID: 28130106 DOI: 10.1016/j.bbrc.2017.01.114

10167 Takahashi K, Suzuki N, Ogra Y. Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo. Int J Mol Sci 2017 18: PubMed ID: 28245633 DOI: 10.3390/ijms18030506

10214 Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T. Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers. Eur. J. Pharmacol. 2017 804:46-51 PubMed ID: 28327343 DOI: 10.1016/j.ejphar.2017.03.041

10227 Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M. Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers. J. Food Sci. 2017 82:1224-1230 PubMed ID: 28346686 DOI: 10.1111/1750-3841.13680

10247 Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y. Carnosine activates the CREB pathway in Caco-2 cells. Cytotechnology 2017 69:523-527 PubMed ID: 28374107 DOI: 10.1007/s10616-017-0089-0

10319 Nakayama T, Funakoshi-Tago M, Tamura H. Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs. Oncol Lett 2017 14:1109-1114 PubMed ID: 28693281 DOI: 10.3892/ol.2017.6227

10325 Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T. Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides. Toxicol. Lett. 2017 277:18-23 PubMed ID: 28552774 DOI: 10.1016/j.toxlet.2017.05.012

10474 Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T. Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism. Biochem. Pharmacol. 2017 145:192-201 PubMed ID: 28843775 DOI: 10.1016/j.bcp.2017.08.016

10552 Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y. Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships. Am. J. Chin. Med. 2017 45:1497-1511 PubMed ID: 29025293 DOI: 10.1142/S0192415X17500811

10635 Yamashita S, Seino T, Aida K, Kinoshita M. Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells. J Oleo Sci 2017 66:1337-1342 PubMed ID: 29199207 DOI: 10.5650/jos.ess17171

10976 Effect of luteolin on the expression of intestinal cholesterol transporters Journal of Functional Foods 2017 36:274-279 DOI: 10.1016/j.jff.2017.07.008

10979 1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis Nutrition Research 2017 46, 59-67 PubMed ID: 28931466 DOI: 10.1016/j.nutres.2017.07.005

10996 Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells Journal of Functional Foods 2017 39, 91-95 DOI: 10.1016/j.jff.2017.10.013

10999 Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity Food Science and Technology Research 2017 23, 725-732 DOI: 10.3136/fstr.23.725

4194 Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T. A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. Lab Chip 2017 PubMed ID: 29184959 DOI: 10.1039/c7lc00952f

10008 Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers J Clin Biochem Nutr 2017 60(2):81-85 PubMed ID: 28366985 DOI: 10.3164/jcbn.16-32

10019 Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes Biochem Biophys Res Commun 2017 486(1):143-148 PubMed ID: 28285137 DOI: 10.1016/j.bbrc.2017.03.014

10025 Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita Design and fabrication of devices for investigating cell-sheet stretch BioChip Journal 2017 11:173–179 DOI: 10.1007/s13206-017-1301-1

10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

10035 Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity J Gastroenterol Hepatol 2017 32(11):1839-1845 PubMed ID: 28295549 DOI: 10.1111/jgh.13785

9931 Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications Front Physiol 2017 8:997 PubMed ID: 29259558 DOI: 10.3389/fphys.2017.00997

14774 Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T. Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism Kidney Int 2017 91(3):658-670 PubMed ID: 27988213 DOI: 10.1016/j.kint.2016.09.041

7107 Yamazoe H, Ichikawa T, Hagihara Y, Iwasaki Y. Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells. Acta Biomater 2016 31:231-240 PubMed ID: 26685756 DOI: 10.1016/j.actbio.2015.12.016

9508 Kaku Y, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T. HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage. Anticancer Res. 2016 36:39-48 PubMed ID: 26722026

9525 Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T. Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer. Int. J. Oncol. 2016 48:1297-304 PubMed ID: 26783196 DOI: 10.3892/ijo.2016.3332

9544 Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S. Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Sci Rep 2016 7:20069 PubMed ID: 26822058 DOI: 10.1038/srep20069

9580 Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K. Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. J Nat Med 2016 70:661-6 PubMed ID: 26899240 DOI: 10.1007/s11418-016-0976-2

9590 Jdir H, Khemakham B, Najjaa H, Chakroun M, Jridi M, Ben Arfa A, Ben Ali Y, Zouari N. Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex. Pharm Biol 2016 54:2111-8 PubMed ID: 26916801 DOI: 10.3109/13880209.2016.1145704

9638 Kaze N, Watanabe Y, Sato H, Murota K, Kotaniguchi M, Yamamoto H, Inui H, Kitamura S. Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters. Lipids 2016 51:913-22 PubMed ID: 27023203 DOI: 10.1007/s11745-016-4143-z

9646 Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T. Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells. J. Biol. Chem. 2016 291:12586-600 PubMed ID: 27053111 DOI: 10.1074/jbc.M116.717561

9688 Kimura O, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y, Endo T. Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers. J. Pharm. Pharmacol. 2016 68:883-9 PubMed ID: 27166429 DOI: 10.1111/jphp.12557

9699 Kudo M, Katayoshi T, Kobayashi-Nakamura K, Akagawa M, Tsuji-Naito K. H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport. Biochem. Biophys. Res. Commun. 2016 475:335-41 PubMed ID: 27216463 DOI: 10.1016/j.bbrc.2016.05.093

10030 Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y. Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation. Oxid Med Cell Longev 2016 2016:2927131 PubMed ID: 27840668 DOI: 10.1155/2016/2927131

10884 Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water Water, Air, & Soil Pollution 2016 227:341 DOI: 10.1007/s11270-016-3049-y

5810 Kitagawa N et al The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines. Int J Mol Sci 2016 17(12). pii: E1979 PubMed ID: 27898032 DOI: 10.3390/ijms17121979

9117 Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis PLoS One 2016 11 (1), e0147957 PubMed ID: 26807591 DOI: 10.1371/journal.pone.0147957

9989 Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro J Vet Med Sci 2016 78(4):627-32 PubMed ID: 26685883 DOI: 10.1292/jvms.15-0595

10107 Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells Nutr Res . 2016 36(11):1269-1276 PubMed ID: 27865621 DOI: 10.1016/j.nutres.2016.10.001

10108 Katsuya Narumi, Masaki Kobayashi, Ayuko Kondo, Ayako Furugen, Takehiro Yamada, Natsuko Takahashi, Ken Iseki Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen Biopharm Drug Dispos 2016 7(8):447-455 PubMed ID: 27514365 DOI: 10.1002/bdd.2026

10110 Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1 Biol Pharm Bull . 2016 39(3):301-7 PubMed ID: 26934923 DOI: 10.1248/bpb.b15-00359

10111 Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi Phytochemistry Letters 2016 17:64-70 DOI: 10.1016/j.phytol.2016.07.024

12897 Iwazaki A, Takahashi N, Miyake R, Hiroshima Y, Abe M, Yasui A, Imai K. Effect of dietary fibers on losartan uptake and transport in Caco-2 cells Biopharm Drug Dispos 2016 37(4):212-9 PubMed ID: 26748460 DOI: 10.1002/bdd.2004

14091 Gakuro Harada, Pawat Pattarawat, Kenji Ito, Takashi Matsumoto, Takanori Hasegawa, Yoshinori Katakura Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1 Journal of Functional Foods 2016 23:444-452 DOI: 10.1016/j.jff.2016.01.016

14133 Guo L, Yamashita H, Kou I, Takimoto A, Meguro-Horike M, Horike S, Sakuma T, Miura S, Adachi T, Yamamoto T, Ikegawa S, Hiraki Y, Shukunami C. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation PLoS Genet 2016 12:e1005802 PubMed ID: 26820155 DOI: 10.1371/journal.pgen.1005802

7117 Shimizu T, Ichimura K, Noda M. The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion. Infect. Immun. 2015 84:537-49 PubMed ID: 26644384 DOI: 10.1128/IAI.00881-15

7203 Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T. The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus. FEMS Microbiol. Lett. 2015 362: PubMed ID: 26394644 DOI: 10.1093/femsle/fnv173

7295 Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K. Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen. Biochem. Pharmacol. 2015 97:89-98 PubMed ID: 26119820 DOI: 10.1016/j.bcp.2015.06.021

7414 Kaku Y, Tsuchiya A, Kanno T, Nishizaki T. Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines. Pharmacology 2015 95:154-9 PubMed ID: 25833236 DOI: 10.1159/000381029

7419 Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways. Int. J. Mol. Med. 2015 35:1603-9 PubMed ID: 25816245 DOI: 10.3892/ijmm.2015.2156

7436 Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S. Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum. Physiol Rep 2015 3: PubMed ID: 25780093 DOI: 10.14814/phy2.12327

7574 Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan. Deep Ocean Water Research 2015 15:117-124

9472 Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura Enhanced Oleate Uptake and Lipotoxicity Associated With Laurate FEBS Open Bio . 2015 May 29;5:485-91 2015 5:485-91 PubMed ID: 26106523 DOI: 10.1016/j.fob.2015.05.008

10118 Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice Exp Cell Res 2015 331(2):408-15 PubMed ID: 25542842 DOI: 10.1016/j.yexcr.2014.12.007

10149 Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto Jpn J Pharm Health Care Sci 2015 41(4): 236―243 DOI: 10.5649/jjphcs.41.236

10150 Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa Sustained Inhibition of Proton-Coupled Folate Transporter by Myricetin Drug Metab Pharmacokinet 2015 30(2):154-9. PubMed ID: 25801697 DOI: 10.1016/j.dmpk.2014.11.001

10151 Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life Eur J Pharm Sci 2015 67:136-143 PubMed ID: 25433245 DOI: 10.1016/j.ejps.2014.11.005

10152 Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy J Control Release 2015 210:19-25 PubMed ID: 25998050 DOI: 10.1016/j.jconrel.2015.05.275

9993 Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption J Nutr Sci Vitaminol (Tokyo) 2015 61(6):449-54 PubMed ID: 26875485 DOI: 10.3177/jnsv.61.449

10154 Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines Energy Procedia 2015 74:878 – 885 DOI: 10.1016/j.egypro.2015.07.823

10156 Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity J Ethnopharmacol 2015 161:147-55 PubMed ID: 25523370 DOI: 10.1016/j.jep.2014.12.009

10157 Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells J Cell Mol Med 2015 19(7):1569-81 PubMed ID: 25689483 DOI: 10.1111/jcmm.12531

10158 Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer Mol Clin Oncol 2015 3(5):1080-1084 PubMed ID: 26623054 DOI: 10.3892/mco.2015.577

10159 Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas Oncology 2015 88(5):309-19 PubMed ID: 25591719 DOI: 10.1159/000369905

10160 Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation J Biol Chem 2015 ;290(28):17439-50 PubMed ID: 26023238 DOI: 10.1074/jbc.M114.594937

10172 Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats Nanomedicine 2015 11(5):1227-36 PubMed ID: 25725490 DOI: 10.1016/j.nano.2015.02.003

14459 Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H. MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells PLoS One 2015 10(5):e0127119 PubMed ID: 25970424 DOI: 10.1371/journal.pone.0127119

15177 Ozeki K, Kato M, Sakurai Y, Ishigai M, Kudo T, Ito K. Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study Int J Pharm 2015 495(2):963-71 PubMed ID: 26387619 DOI: 10.1016/j.ijpharm.2015.09.035

17443 Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T. An on-chip small intestine-liver model for pharmacokinetic studies J Lab Autom 2015 20(3):265-73 PubMed ID: 25385717 DOI: 10.1177/2211068214557812

17455 Shimozato O, Waraya M, Nakashima K, Souda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T. Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation Oncogene 2015 34(15):1949-60 PubMed ID: 24882578 DOI: 10.1038/onc.2014.141

10196 Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats PLoS One 2014 9(5):e97901 PubMed ID: 24859282 DOI: 10.1371/journal.pone.0097901

10198 Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells Food Chem 2014 154:145-50 PubMed ID: 24518326 DOI: 10.1016/j.foodchem.2013.12.069

10199 Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells Pestic Biochem Physiol . 2014 111:38-42 PubMed ID: 24861932 DOI: 10.1016/j.pestbp.2014.04.002

10202 Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells Biol Pharm Bull 2014 37(3):490-2 PubMed ID: 24583869 DOI: 10.1248/bpb.b13-00700

10203 Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO) Life Sci . 2014 107(1-2):14-20 PubMed ID: 24792517 DOI: 10.1016/j.lfs.2014.04.026

10204 Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters Biol Pharm Bull . 2014 37(9):1475-9 PubMed ID: 25177030 DOI: 10.1248/bpb.b14-00219

10208 Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption Drug Metab Pharmacokinet 2014 29(5):414-8 PubMed ID: 24806820 DOI: 10.2133/dmpk.dmpk-14-rg-001

10209 Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation FEBS Lett . 2014 588(11):1997-2002 PubMed ID: 24792722 DOI: 10.1016/j.febslet.2014.04.025

10223 Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases Cancer Chemother Pharmacol 2014 74(5):1023-8 PubMed ID: 25205428 DOI: 10.1007/s00280-014-2578-6

10224 Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto Induction of AhR-mediated Gene Transcription by Coffee PLoS One 2014 9(7):e102152 PubMed ID: 25007155 DOI: 10.1371/journal.pone.0102152

10225 Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin Drug Metab Pharmacokinet 2014 29(4):312-6 PubMed ID: 24492671 DOI: 10.2133/dmpk.dmpk-13-rg-107

10226 Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion J Pharm Pharm Sci 2014 17(2):266-76 PubMed ID: 24934555 DOI: 10.18433/j3jg7d

10229 Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin Biopharm Drug Dispos 2014 35(6):321-9 PubMed ID: 24801141 DOI: 10.1002/bdd.1900

10237 Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures Tumour Biol 2014 35(12):12689-93 PubMed ID: 25217322 DOI: 10.1007/s13277-014-2593-6

10242 T Nakayama, K Ezoe Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O Curr Microbiol . 2014 69(5):690-8 PubMed ID: 24974216 DOI: 10.1007/s00284-014-0639-z

10243 Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke Sci Technol Adv Mater 2014 15(3):035002 PubMed ID: 27877678 DOI: 10.1088/1468-6996/15/3/035002

10244 Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation Immunol Cell Biol 2014 92(7):624-30 PubMed ID: 24777307 DOI: 10.1038/icb.2014.31

10254 Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells J Clin Biochem Nutr 2014 55(3):162-7 PubMed ID: 25411520 DOI: 10.3164/jcbn.14-25

10259 Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure Electric Stimulus Opens Intercellular Spaces in Skin J Biol Chem 2014 24;289(4):2450-6 PubMed ID: 24318878 DOI: 10.1074/jbc.M113.514414

10262 Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D FEMS Microbiol Lett 2014 2014 Aug;357(2):115-22 PubMed ID: 25041523 DOI: 10.1111/1574-6968.12527

6429 Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T. Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction. Biochim Biophys Acta 2013 1832(1):151-9 PubMed ID: 23064287 DOI: 10.1016/j.bbadis.2012.10.006

12694 Isshiki M, Ohta H, Tamura H. Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells Biol Pharm Bull 2013 36(2):299-304 PubMed ID: 23370358 DOI: 10.1248/bpb.b12-00902

12695 Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H. Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells J Pharm Pharmacol 2013 65(1):22-9 PubMed ID: 23215684 DOI: 10.1111/j.2042-7158.2012.01569.x

12696 Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K. An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells 3 Biotech 2013 3(3):213-218 PubMed ID: 28324370 DOI: 10.1007/s13205-012-0085-1

12697 Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J. Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1 World J Gastroenterol 2013 19(33):5500-7 PubMed ID: 24023493 DOI: 10.3748/wjg.v19.i33.5500

12698 Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H. Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes Biol Pharm Bull 2013 36(11):1862-6 PubMed ID: 24189430 DOI: 10.1248/bpb.b13-00471

12699 Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S. Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation J Biol Chem 2013 288(19):13317-24 PubMed ID: 23532847 DOI: 10.1074/jbc.M113.459875

12700 Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H. INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors Biochem Biophys Res Commun 2013 432(4):586-92 PubMed ID: 23438439 DOI: 10.1016/j.bbrc.2013.02.042

12701 Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J. Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery Eur J Pharm Sci 2013 50(3-4):303-11 PubMed ID: 23896171 DOI: 10.1016/j.ejps.2013.07.010

12702 Kamishikiryo J, Matsumura R, Takamori T, Sugihara N. Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid J Pharm Pharmacol 2013 65(7):1037-43 PubMed ID: 23738731 DOI: 10.1111/jphp.12062

12703 Kimura R, Rokkaku T, Takeda S, Senba M, Mori N. Cytotoxic effects of fucoidan nanoparticles against osteosarcoma Mar Drugs 2013 11(11):4267-78 PubMed ID: 24177673 DOI: 10.3390/md11114267

12704 Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K. Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections Microb Pathog 2013 65:14-20 PubMed ID: 24036179 DOI: 10.1016/j.micpath.2013.08.006

12705 Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N. Dlg5 interacts with the TGF-β receptor and promotes its degradation FEBS Lett 2013 587(11):1624-9 PubMed ID: 23624079 DOI: 10.1016/j.febslet.2013.04.015

12706 Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K. Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides Int Immunopharmacol 2013 17(4):1009-19 PubMed ID: 24126111 DOI: 10.1016/j.intimp.2013.09.023

12693 Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y. Possible involvement of Wnt11 in colorectal cancer progression Mol Carcinog 2013 52(3):207-17 PubMed ID: 22161723 DOI: 10.1002/mc.21845

15922 Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y. Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers Proc Natl Acad Sci U S A 2013 110(6):2105-10 PubMed ID: 23345451 DOI: 10.1073/pnas.1214233110

15924 KATSUHITO ARAI – TAMIKO YAMAZAKI – YOSHIHIKO TOKUJI – MIKA KAWAHARA – KIYOSHI OHBA – KAZUNORI HIRONAKA – MIKIO KINOSHITA – MASAO OHNISHI Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice Journal of Food and Nutrition Research 2013 52:139–145

15925 Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S. Relationship between methyl CpG binding protein 2 and JC viral proteins Jpn J Infect Dis 2013 66(2):126-32. PubMed ID: 23514909 DOI: 10.7883/yoken.66.126

21985 Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y. Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene 2013 32(41):4903-12 PubMed ID: 23208499 DOI: 10.1038/onc.2012.516

7607 Kimura O, Tsukagoshi K, Hayasaka M, Endo T. Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers. Basic Clin. Pharmacol. Toxicol. 2012 110:530-6 PubMed ID: 22181038 DOI: 10.1111/j.1742-7843.2011.00850.x

7625 Ito N, Ohtsubo T, Kusu F, Hakamata H. An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells. Anal. Biochem. 2012 421:86-91 PubMed ID: 22119071 DOI: 10.1016/j.ab.2011.10.051

6316 Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F. Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer. Int J Oncol 2012 40(1):217-26 PubMed ID: 21901246 DOI: 10.3892/ijo.2011.1189

10981 Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells J Med Food 2012 15(6):511-9 PubMed ID: 22510151 DOI: 10.1089/jmf.2012.0040

12711 Kimura O, Tsukagoshi K, Hayasaka M, Endo T. Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells Arch Toxicol 2012 86(1):55-61 PubMed ID: 21766207 DOI: 10.1007/s00204-011-0734-x

12712 Yanagihara S, Hirota T, Yamamoto N. Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells J Biosci Bioeng 2012 114(6):582-5 PubMed ID: 22841868 DOI: 10.1016/j.jbiosc.2012.07.001

12713 Matsuo Y, Miyoshi Y, Okada S, Satoh E. Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri Biosci Microbiota Food Health 2012 31(4):93-102 PubMed ID: 24936355 DOI: 10.12938/bmfh.31.93

12714 Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer Eur J Cancer 2012 48(14):2244-51. PubMed ID: 22197219 DOI: 10.1016/j.ejca.2011.11.032

12715 Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K. Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins Acta Med Okayama 2012 66(3):253-61 PubMed ID: 22729106 DOI: 10.18926/AMO/48565

12716 Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K. Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein J Pharm Pharm Sci 2012 15(2):256-64 PubMed ID: 22579005 DOI: 10.18433/j38k56

12722 Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T. Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine J Sci Food Agric 2012 92(4):857-61 PubMed ID: 21969243 DOI: 10.1002/jsfa.4658

12724 Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M. Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients Ann Surg Oncol 2012 19 Suppl 3:S518-27 PubMed ID: 21845497 DOI: 10.1245/s10434-011-1993-8

12729 Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K. Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP J Pharm Pharm Sci 2012 15(2):295-304 PubMed ID: 22579008 DOI: 10.18433/j3w896

12731 Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu” Food Science and Technology Research 2012 18:825-834 DOI: 10.3136/fstr.18.825

12732 Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N. Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate J Food Sci 2012 77(10):H208-15 PubMed ID: 22938538 DOI: 10.1111/j.1750-3841.2012.02902.x

12733 Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M. A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers Biol Pharm Bull 2012 35(1):1-9 PubMed ID: 22223330 DOI: 10.1248/bpb.35.1

12740 Chaisowwong W, Kusumoto A, Hashimoto M, Harada T, Maklon K, Kawamoto K. Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat J Vet Med Sci 2012 74(1):43-50 PubMed ID: 21891974 DOI: 10.1292/jvms.11-0305

16159 Megumi Ishimura, Mika Sakurai-Yageta, Tomoko Maruyama, Tomoko Ando, Masashi Fukayama, Akiteru Goto, Yoshinori Murakami Involvement of miR-214 and miR-375 in Malignant Features of Non-Small-Cell Lung Cancer by Down-Regulating CADM1 Journal of Cancer Therapy 2012 03:379-387 DOI: 10.4236/jct.2012.324050

7622 Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y. Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice. Biol. Pharm. Bull. 2011 34:1885-9 PubMed ID: 22130247 DOI: 10.1248/bpb.34.1885

7653 Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M. Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum. Biomed. Res. 2011 32:313-20 PubMed ID: 22033300 DOI: 10.2220/biomedres.32.313

7668 Isshiki M, Umezawa K, Tamura H. Coffee induces breast cancer resistance protein expression in Caco-2 cells. Biol. Pharm. Bull. 2011 34:1624-7 PubMed ID: 21963506 DOI: 10.1248/bpb.34.1624

7735 Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M. Isolation and characterization of a novel short peptide associated with Crohn's disease. Clin. Exp. Immunol. 2011 166:72-9 PubMed ID: 21797848 DOI: 10.1111/j.1365-2249.2011.04444.x

7749 Ashida N, Yanagihara S, Shinoda T, Yamamoto N. Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis. J. Biosci. Bioeng. 2011 112:333-7 PubMed ID: 21763196 DOI: 10.1016/j.jbiosc.2011.06.001

7783 Kimura O, Kotaki Y, Hamaue N, Haraguchi K, Endo T. Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers. Food Chem. Toxicol. 2011 49:2167-71 PubMed ID: 21672599 DOI: 10.1016/j.fct.2011.06.001

7820 Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y. Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells. Biopharm Drug Dispos 2011 32:253-60 PubMed ID: 21567399 DOI: 10.1002/bdd.755

7988 Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J. Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells. J. Agric. Food Chem. 2011 59:1470-6 PubMed ID: 21226458 DOI: 10.1021/jf103820b

8039 Tsuruta H, Yagishita T, Shimizu M, Tamura H. Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2. Toxicol In Vitro 2011 25:500-4 PubMed ID: 21144891 DOI: 10.1016/j.tiv.2010.12.002

8051 Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S. Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. J. Biol. Chem. 2011 286:2750-61 PubMed ID: 21084306 DOI: 10.1074/jbc.M110.171504

18940 Norikura T, Fujiwara K, Narita T, Yamaguchi S, Morinaga Y, Iwai K, Matsue H. Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta J Agric Food Chem 2011 59(13):6974-9 PubMed ID: 21630659 DOI: 10.1021/jf200461j

9083 Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis Infect Immun 2011 79 (11), 4353-60 PubMed ID: 21911469 DOI: 10.1128/IAI.05677-11

9085 Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli Gene 2011 478 (1-2), 1-10 PubMed ID: 21262333 DOI: 10.1016/j.gene.2011.01.006

12742 Takeda S, Yamasaki K, Takeshita M, Kikuchi Y, Tsend-Ayush C, Dashnyam B, Ahhmed AM, Kawahara S, Muguruma M. The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products Anim Sci J 2011 82(4):571-9 PubMed ID: 21794017 DOI: 10.1111/j.1740-0929.2011.00874.x

12744 Okumura S, Saitoh H, Ishikawa T, Inouye K, Mizuki E. Mode of action of parasporin-4, a cytocidal protein from Bacillus thuringiensis Biochim Biophys Acta 2011 1808(6):1476-82 PubMed ID: 21073856 DOI: 10.1016/j.bbamem.2010.11.003

15705 Masayuki TAKEUCHI, Katsuki OHTANI, Yanju MA, Sanae KATO, Shingo SEMBA, Tsuyoshi KATOH, Nobutaka WAKAMIYA, Takanobu TANIGUCHI Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lin Food Science and Technology Research 2011 17:515-521 DOI: 10.3136/fstr.17.515

16160 Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid Int J Pharm 2011 403(1-2):136-8 PubMed ID: 20933071 DOI: 10.1016/j.ijpharm.2010.09.035

8119 Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M. Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy. JPEN J Parenter Enteral Nutr 2010 34:530-7 PubMed ID: 20852181 DOI: 10.1177/0148607110362694

8137 Wang C, Ho PC, Lim LY. Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells. Int J Pharm 2010 400:201-10 PubMed ID: 20804835 DOI: 10.1016/j.ijpharm.2010.08.023

8144 Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T. Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition Cell. Physiol. Biochem. 2010 26:125-34 PubMed ID: 20798496 DOI: 10.1159/000320518

8156 Watanabe K, Kamata K, Sato J, Takahashi T. Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption. J Ethnopharmacol 2010 132:193-9 PubMed ID: 20713144 DOI: 10.1016/j.jep.2010.08.014

8186 Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y. Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion. Br. J. Cancer 2010 103:517-23 PubMed ID: 20628387 DOI: 10.1038/sj.bjc.6605786

8386 Takahashi T, Kaku T, Sato T, Watanabe K, Sato J. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med 2010 64:55-62 PubMed ID: 20091240 DOI: 10.1007/s11418-009-0371-3

8429 Narita K, Kawate T, Kakinuma N, Takeda S. Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium. Traffic 2010 11:287-301 PubMed ID: 19958467 DOI: 10.1111/j.1600-0854.2009.01016.x

18483 Imura Y, Sato K, Yoshimura E. Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity Anal Chem 2010 82(24):9983-8 PubMed ID: 21090751 DOI: 10.1021/ac100806x

12749 Shirou Itagaki et al. Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2 Food Chemistry 2010 120(2):552-555 DOI: 10.1016/j.foodchem.2009.10.052

12766 Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T. Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer Cell Physiol Biochem 2010 54(8):1182-91 PubMed ID: 20112302 DOI: 10.1002/mnfr.200900348

12751 Nagamatsu Y, Okamura S, Saitou H, Akao T, Mizuki E. Three Cry toxins in two types from Bacillus thuringiensis strain M019 preferentially kill human hepatocyte cancer and uterus cervix cancer cells Biosci Biotechnol Biochem 2010 74(3):494-8 PubMed ID: 20208360 DOI: 10.1271/bbb.90615

12752 Mari Takaai, Jumpei Sakata, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto Mechanisms for Transport of Methotrexate across Apical and Basolateral Membranes in Human Intestinal Epithelial Caco-2 Cells ryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 2010 36:63 DOI: 10.5649/jjphcs.36.63

12753 Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y, Nishimura Y. The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy Int J Cancer 2010 126(9):2153-63 PubMed ID: 19688828 DOI: 10.1002/ijc.24836

15672 Yamasaki T, Kawamura K, Hatori A, Yui J, Yanamoto K, Yoshida Y, Ogawa M, Nengaki N, Wakisaka H, Fukumura T, Zhang MR. PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein Nucl Med Commun 2010 31(11):985-93 PubMed ID: 20859232 DOI: 10.1097/MNM.0b013e32833fbf87

8476 Yamanashi Y, Takada T, Suzuki H. In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers. Pharmacogenet. Genomics 2009 19:884-92 PubMed ID: 19823104 DOI: 10.1097/FPC.0b013e3283327925

8512 Yoshimura S, Kawano K, Matsumura R, Sugihara N, Furuno K. Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. J. Biomed. Biotechnol. 2009 2009:467489 PubMed ID: 19688110 DOI: 10.1155/2009/467489

8569 Kimura O, Tsukagoshi K, Endo T. Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters. Toxicol. Lett. 2009 189:102-9 PubMed ID: 19465094 DOI: 10.1016/j.toxlet.2009.05.006

8666 Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T. Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors. J. Gastroenterol. 2009 44:56-65 PubMed ID: 19159073 DOI: 10.1007/s00535-008-2273-7

8698 Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A. Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice. J. Nutr. 2009 139:69-75 PubMed ID: 19056655 DOI: 10.3945/jn.108.092528

5877 Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. Biol Pharm Bull 2009 32(7):1148-54 PubMed ID: 19571376 DOI: 10.1248/bpb.32.1148

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

12761 Sugawara T, Yamashita K, Asai A, Nagao A, Shiraishi T, Imai I, Hirata T. Esterification of xanthophylls by human intestinal Caco-2 cells Arch Biochem Biophys 2009 483(2):205-12 PubMed ID: 18952044 DOI: 10.1016/j.abb.2008.10.007

12762 Ishida K, Taguchi M, Akao T, Hashimoto Y. Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells Biol Pharm Bull 2009 32(3):513-6 PubMed ID: 19252307 DOI: 10.1248/bpb.32.513

12763 Kazuhiro Yamamoto, Hideki Hakamata, Akira Yamaguchi, Fumiyo Kusu An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers Anal Bioanal Chem 2009 395(2):533-8 PubMed ID: 19641905 DOI: 10.1007/s00216-009-2976-5

12765 Fukumori S, Masago M, Ishida K, Kayano Y, Taguchi M, Hashimoto Y. Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells Biopharm Drug Dispos 2009 30(8):448-56 PubMed ID: 19725017 DOI: 10.1002/bdd.679

12773 Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y. Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma Biochem Biophys Res Commun 2009 383(4):480-4 PubMed ID: 19371721 DOI: 10.1016/j.bbrc.2009.04.039

8700 Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K. Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice. Biosci. Biotechnol. Biochem. 2008 72:3148-57 PubMed ID: 19060399 DOI: 10.1271/bbb.80324

8715 Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J. Agric. Food Chem. 2008 56:10515-20 PubMed ID: 18959405 DOI: 10.1021/jf8020877

8757 Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M. Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria. Biol. Pharm. Bull. 2008 31:949-54 PubMed ID: 18451525 DOI: 10.1248/bpb.31.949

10207 Ayako Saruwatari, Shigeaki Okamura, Yoko Nakajima, Yuji Narukawa, Tadahiro Takeda, Hiroomi Tamura Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells J Med Food 2008 11(4):623-8 PubMed ID: 19053852 DOI: 10.1089/jmf.2007.0050

12774 Saruwatari A, Isshiki M, Tamura H. Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells iol Pharm Bull 2008 31(11):2131-6 PubMed ID: 18981586 DOI: 10.1248/bpb.31.2131

12775 Seki T, Harada S, Hosoya O, Morimoto K, Juni K. Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes Biol Pharm Bull 2008 31(1):163-6 PubMed ID: 18175963 DOI: 10.1248/bpb.31.163

12776 Kimura O, Tsukagoshi K, Endo T. Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter Toxicol Appl Pharmacol 2008 227(3):325-30 PubMed ID: 18096194 DOI: 10.1016/j.taap.2007.10.028

12777 Kimura H, Yamamoto T, Sakai H, Sakai Y, Fujii T. An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models Lab Chip 2008 8(5):741-6 PubMed ID: 18432344 DOI: 10.1039/b717091b

12778 Han Y, Chin Tan TM, Lim LY. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression Toxicol Appl Pharmacol 2008 230(3):283-9 PubMed ID: 18417181 DOI: 10.1016/j.taap.2008.02.026

12779 Fukumori S, Murata T, Takaai M, Tahara K, Taguchi M, Hashimoto Y. The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells Drug Metab Pharmacokinet 2008 23(5):373-8 PubMed ID: 18974615 DOI: 10.2133/dmpk.23.373

12780 Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M. Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia J Lipid Res 2008 49(4):763-72. PubMed ID: 18180267 DOI: 10.1194/jlr.M700293-JLR200

12781 Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y. The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption Cell Microbiol 2008 10(2):355-64 PubMed ID: 17868282 DOI: 10.1111/j.1462-5822.2007.01048.x

12785 Takaai M, Morishita H, Ishida K, Taguchi M, Hashimoto Y. Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells Eur J Pharmacol 2008 601(1-3):61-5 PubMed ID: 19013148 DOI: 10.1016/j.ejphar.2008.10.047

12786 Kadowaki M, Sugihara N, Tagashira T, Terao K, Furuno K. Presence or absence of a gallate moiety on catechins affects their cellular transport J Pharm Pharmacol 2008 60(9):1189-95 PubMed ID: 18718123 DOI: 10.1211/jpp.60.9.0011

12788 Shah AK, Kinoshita M, Kurihara H, Ohnishi M, Takahashi K. Glycosylceramides obtain from the starfish Asterias amurensis Lütken J Oleo Sci 2008 57(9):477-84 PubMed ID: 18685230 DOI: 10.5650/jos.57.477

12791 Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y. Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity Biol Pharm Bull 2008 31(10):1933-7 PubMed ID: 18827358 DOI: 10.1248/bpb.31.1933

12796 Chono S, Takeda E, Seki T, Morimoto K. Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin Int J Pharm 2008 347(1-2):71-8 PubMed ID: 17689212 DOI: 10.1016/j.ijpharm.2007.06.037

8807 Katsube T, Tsuji H, Onoda M. Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell. Biochim. Biophys. Acta 2007 1773:794-803 PubMed ID: 17451824 DOI: 10.1016/j.bbamcr.2007.03.002

8846 Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H. Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells. Br. J. Pharmacol. 2007 150:209-19 PubMed ID: 17160010 DOI: 10.1038/sj.bjp.0706972

3580 Ito T, Maki N, Hazeki O, Sasaki K, Nekooki M. Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines. Cell Biol Int 2007 31(12):1518-24 PubMed ID: 17719804 DOI: 10.1016/j.cellbi.2007.06.017

3692 Arimochi J, Ohashi-Kobayashi A, Maeda M. Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells. Biol Pharm Bull 2007 30(4):648-54 PubMed ID: 17409496 DOI: 10.1248/bpb.30.648

3599 Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R. Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters. Biosci Biotechnol Biochem 2007 71(8):1886-95 PubMed ID: 17690481 DOI: 10.1271/bbb.70109

9059 Y-C Jung, E Mizuki, T Akao, J-C Côté Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells J Appl Microbiol 2007 103 (1), 65-79 PubMed ID: 17584453 DOI: 10.1111/j.1365-2672.2006.03260.x

9062 Hitoshi HORIE, Yuichi FUJII, Kouji KATABAMI, Masanori IWAMA, Akira YAMADA Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype Journal of Traditional Medicines 2007 24: 156-163 DOI: 10.11339/jtm.24.156

11676 Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, Tomohiro Hosoi Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid Biosci Biotechnol Biochem 2007 71(10):2428-34 PubMed ID: 17928716 DOI: 10.1271/bbb.70172

12815 Satoko GUNJI, Joko SANTOSO, Yumiko YOSHIE-STARK, Takeshi SUZUKI Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide Food Science and Technology Research 2007 13:275-279 DOI: 10.3136/fstr.13.27

12799 Oda M, Fujimoto K, Kobayashi M, Saitoh H. Bacampicillin uptake is shared with thiamine in Caco-2 cells Biol Pharm Bull 2007 30(7):1344-9 PubMed ID: 17603179 DOI: 10.1248/bpb.30.1344

12800 Sugihara N, Toyama K, Okamoto T, Kadowaki M, Terao K, Furuno K. Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach Toxicol In Vitro 2007 21(5):827-34 PubMed ID: 17408918 DOI: 10.1016/j.tiv.2007.02.005

12801 Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y. Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers Biol Pharm Bull . 2007 Nov;30(11):2167-72 2007 30(11):2167-72 PubMed ID: 17978494 DOI: 10.1248/bpb.30.2167

12802 Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation World J Gastroenterol 2007 13(19):2717-21 PubMed ID: 17569141 DOI: 10.3748/wjg.v13.i19.2717

12804 Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y. Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells Biol Pharm Bull 2007 30(10):1930-3 PubMed ID: 17917264 DOI: 10.1248/bpb.30.1930

12805 Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K. Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro Am J Physiol Gastrointest Liver Physiol 2007 292(3):G923-9 PubMed ID: 17170030 DOI: 10.1152/ajpgi.00145.2006

12807 Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E. Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells J Biol Chem 2007 282(10):7742-52 PubMed ID: 17204466 DOI: 10.1074/jbc.M611382200

12810 Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats Asian-Australasian Journal of Animal Sciences 2007 20(7): 1120-1126 DOI: 10.5713/ajas.2007.1120

12811 Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T. Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport J Pharm Pharmacol 2007 59(10):1383-7 PubMed ID: 17910813 DOI: 10.1211/jpp.59.10.0008

3432 Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist. Drug Metab Dispos 2006 34:369-74 PubMed ID: 16326817 DOI: 10.1124/dmd.105.006213

3404 Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo. J Pharm Sci 2006 95:552-60 PubMed ID: 16419049 DOI: 10.1002/jps.20563

8890 Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K. Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction. Biol. Pharm. Bull. 2006 29:535-8 PubMed ID: 16508161 DOI: 10.1248/bpb.29.535

12816 Han Y, Tan TM, Lim LY. Effects of capsaicin on P-gp function and expression in Caco-2 cells Biochem Pharmacol 2006 71(12):1727-34 PubMed ID: 16674925 DOI: 10.1016/j.bcp.2006.03.024

12817 Watanabe K, Jinriki T, Sato J. Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2 Biol Pharm Bull 2006 29(1):90-5 PubMed ID: 16394517 DOI: 10.1248/bpb.29.90

12818 Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T. Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells Biosci Biotechnol Biochem 2006 70(12):2906-12 PubMed ID: 17151482 DOI: 10.1271/bbb.60318

12819 Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K. Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers J Pharm Sci 2006 95(6):1393-401 PubMed ID: 16625653 DOI: 10.1002/jps.20616

12820 M Gueimonde et al Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli Food Research International 2006 39:467-471 DOI: 10.1016/j.foodres.2005.10.003

12821 Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K. Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer Toxicology 2006 223(1-2):156-65 PubMed ID: 16647797 DOI: 10.1016/j.tox.2006.03.011

12822 Ishida K, Takaai M, Hashimoto Y. Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells Biol Pharm Bull 2006 29(3):522-6 PubMed ID: 16508158 DOI: 10.1248/bpb.29.522

12823 Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells Food Science and Technology Research 2006 12:290-294 DOI: 10.3136/fstr.12.290

12824 Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y. Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines J Gastroenterol 2006 2006 Feb;41(2):140-50 PubMed ID: 16568373 DOI: 10.1007/s00535-005-1733-6

12825 Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y. Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF Hepatol Res 2006 35(3):152-62 PubMed ID: 16707273 DOI: 10.1016/j.hepres.2006.03.011

12826 Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K. Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli Protein Expr Purif 2006 47(1):144-51 PubMed ID: 16307894 DOI: 10.1016/j.pep.2005.10.011

12827 Makoto KIMURA, Kuninaga DANNO, Hisako YASUI Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk Bioscience and Microflora 2006 25:147-155 DOI: 10.12938/bifidus.25.147

12828 Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S. Determination of p-glycoprotein ATPase activity using luciferase Biol Pharm Bull 2006 29(3):560-4 PubMed ID: 16508168 DOI: 10.1248/bpb.29.560

3413 Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells. J Biochem 2005 138:663-72 PubMed ID: 16428294 DOI: 10.1093/jb/mvi177

2892 Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis J Biochem (Tokyo) 2005 137:17-25 PubMed ID: 15713879 DOI: 10.1093/jb/mvi003

3026 Aiba T, Susa M, Fukumori S, Hashimoto Y The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180 Drug Metab Pharmacokinet 2005 20:268-274 PubMed ID: 16141606 DOI: 10.2133/dmpk.20.268

3025 Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers. Biol Pharm Bull 2005 28:114-9 PubMed ID: 15635174 DOI: 10.1248/bpb.28.114

3072 Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells. Biosci Biotechnol Biochem 2005 69:202-5 PubMed ID: 15665486 DOI: 10.1271/bbb.69.202

3300 Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice. Biol Pharm Bull 2005 28:527-30 PubMed ID: 15744083 DOI: 10.1248/bpb.28.527

3155 Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans. Int J Vitam Nutr Res 2005 75:39-46 PubMed ID: 15830920 DOI: 10.1024/0300-9831.75.1.39

3164 Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures. Biochemistry 2005 44:6343-9 PubMed ID: 15835923 DOI: 10.1021/bi047606a

3270 Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y. Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Hepatol. Res. 2005 33:198-205 PubMed ID: 16198622 DOI: 10.1016/j.hepres.2005.08.005

9134 Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D. CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS Chiang Mai Med Bull 2005 44:21-28

9048 Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines J Agric Food Chem 2005 53 (16), 6313-8 PubMed ID: 16076112 DOI: 10.1021/jf0506129

12832 Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2 Food Science and Technology Research 2005 11:202-206 DOI: 10.3136/fstr.11.202

12833 Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO. The effects of coffee on conjugation reactions in human colon carcinoma cells Biol Pharm Bull 2005 28(2):271-4 PubMed ID: 15684482 DOI: 10.1248/bpb.28.271

12835 Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E. Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene Biochim Biophys Acta 2005 1732(1-3):43-52 PubMed ID: 16380173 DOI: 10.1016/j.bbaexp.2005.11.003

2720 Saegusa S, Totsuka M, Kaminogawa S, Hosoi T Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid. FEMS Immunol Med Microbiol 2004 41:227-35 PubMed ID: 15196572 DOI: 10.1016/j.femsim.2004.03.006

2736 Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2. Eur J Pharm Sci 2004 21:87-95 PubMed ID: 14706815 DOI: 10.1016/j.ejps.2003.10.002

2894 Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells. J Biol Chem 2004 279:21282-6 PubMed ID: 15026424 DOI: 10.1074/jbc.M401881200

2735 Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2. Biol Pharm Bull 2004 27:559-63 PubMed ID: 15056866 DOI: 10.1248/bpb.27.559

3199 Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells. Am J Physiol Cell Physiol 2004 287:C1404-11 PubMed ID: 15229109 DOI: 10.1152/ajpcell.00471.2003

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3094 Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res 2004 64:6410-5 PubMed ID: 15374948 DOI: 10.1158/0008-5472.CAN-04-1543

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12839 Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M. Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells Biosci Biotechnol Biochem 2004 68(12):2541-6 PubMed ID: 15618625 DOI: 10.1271/bbb.68.2541

12840 Shigeaki Okamura, Hiro-omi Tamura Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2 Journal of Health Science 2004 50:189-192 DOI: 10.1248/jhs.50.189

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2645 Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto). Int J Food Microbiol 2003 82:255-64 PubMed ID: 12593928 DOI: 10.1016/s0168-1605(02)00311-2

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2629 Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. Biochem Biophys Res Commun 2002 296:625-30 PubMed ID: 12176027 DOI: 10.1016/s0006-291x(02)00853-7

2633 Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2. Biol Pharm Bull 2002 25:1345-50 PubMed ID: 12392092 DOI: 10.1248/bpb.25.1345

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