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Cell No. : Cell Name
RCB0988 : CACO-2  update : 2024/05/24
CommentHuman colon carcinoma. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 86010202 prior to order. Application consideration
Comment from the depositor
Terms and conditionsAbcam Inc doing business as NaviCyte Scientific holds the exclusive commercial distribution rights to the CACO-2 cell line deposited by the Memorial Sloan-Kettering Cancer Center. Note : All uses of Catalogue Number RCB0988, other than for research by a non-commercial or academic entity, require a license and use authorization from Abcam Inc doing business as NaviCyte Scientific under its exclusive arrangement with Memorial Sloan-Kettering Cancer Center. For information on the licensing terms, please contact Abcam Inc doing business as NaviCyte Scientific via or phone +44(0) 1223 696000.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor ECACC
Year of deposit 1994
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 72 years
Tissue colon
Disease name adenocarcinoma
Classification cancer
History overseas, ECACC
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0025
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 20% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 85-99(50) : /90(3),91(8),92(4),93(5),94(6)/
STR(human) OK
deposit info
lot info
Reference information Reference 1
User's Publication 453

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1170  Fogh J, Wright, W C, Loveless, J D  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.  J Natl Cancer Inst  1977  58:209-14  PubMed ID: 833871   DOI: 10.1093/jnci/58.2.209

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User's Publication
19855  Kida R, Tsugane M, Suzuki H.  Horizontal and vertical microchamber platforms for evaluation of the paracellular permeability of an epithelial cell monolayer  Lab Chip  2024  24(3):572-583  PubMed ID: 38175144   DOI: 10.1039/d3lc00855j
19990  Kiriko Iida, Asuka Iwasa, Yuuki Amano, Koshu Okubo, Junichi Hirahashi, Hiroshi Kawakami  Preventive effect of lactoferrin peptides on ulcerative colitis  International Dairy Journal  2024  150:105832    DOI: 10.1016/j.idairyj.2023.105832
21644  Nonaka S, Okamoto R, Katsuta Y, Kanetsuki S, Nakanishi H.  Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol.  Biochem Biophys Res Commun  2024  707:149783  PubMed ID: 38493746   DOI: 10.1016/j.bbrc.2024.149783
21669  Miyasaka K, Takada R, Wu J, Takeda S, Manse Y, Morikawa T, Shimoda H.  Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption.  J Nat Med  2024    PubMed ID: 38587581   DOI: 10.1007/s11418-024-01791-5
21702  Ikuno Y, Tsujino H, Haga Y, Manabe S, Idehara W, Hokaku M, Asahara H, Higashisaka K, Tsutsumi Y.  Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.  Ecotoxicol Environ Saf  2024  277:116346  PubMed ID: 38669869   DOI: 10.1016/j.ecoenv.2024.116346
21709  Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T.  Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.  J Gastroenterol  2024    PubMed ID: 38695904   DOI: 10.1007/s00535-024-02104-z
21729  Tanaka Y, Inaba C, Sawa T, Endo K, Saiki T, Haga H, Niitsuma F, Kawahara T, Watanabe J, Tanaka S.  Heat-killed Lactiplantibacillus plantarum Shinshu N-07 exerts antiobesity effects in western diet-induced obese mice.  J Appl Microbiol  2024    PubMed ID: 38740521   DOI: 10.1093/jambio/lxae119
21747  Nagasawa M, Onuki M, Imoto N, Tanaka K, Tanaka R, Kawada M, Imato K, Iitani K, Tsuchido Y, Takeda N.  Fabrication of 3D engineered intestinal tissue producing abundant mucus by air-liquid interface culture using paper-based dual-layer scaffold.  Biofabrication  2024    PubMed ID: 38788705   DOI: 10.1088/1758-5090/ad504b
21748  Nakatani E, Sasai M, Miyazaki H, Tanaka S, Hirota T, Okura T.  Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in Caco-2 Cells.  J Agric Food Chem  2024    PubMed ID: 38789103   DOI: 10.1021/acs.jafc.4c00974
21790  Fujita S, Plianchaisuk A, Deguchi S, Ito H, Nao N, Wang L, Nasser H, Tamura T, Kimura I, Kashima Y, Suzuki R, Suzuki S, Kida I, Tsuda M, Oda Y, Hashimoto R, Watanabe Y, Uriu K, Yamasoba D, Guo Z, Hinay AA Jr, Kosugi Y, Chen L, Pan L, Kaku Y, Chu H, Donati F, Temmam S, Eloit M, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Suzuki Y, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Ikeda T, Tanaka S, Matsuno K, Fukuhara T, Takayama K, Sato K.  Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236.  EBioMedicine  2024  104:105181  PubMed ID: 38838469   DOI: 10.1016/j.ebiom.2024.105181
17773  Watanabe K, Negoro R, Fujita T.  5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells  Biochem Biophys Res Commun  2023  664:94-99  PubMed ID: 37141642   DOI: 10.1016/j.bbrc.2023.04.077
17774  Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H.  Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells  Biosci Biotechnol Biochem  2023  zbad030  PubMed ID: 36941128   DOI: 10.1093/bbb/zbad030
17775  Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima  The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells  J. Excipients and Food Chem  2023  14:22-32   
17776  Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.  Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels  BMC Cancer  2023  23(1):356  PubMed ID: 37072777   DOI: 10.1186/s12885-023-10845-y
17778  Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai  Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα  Drug Metabolism and Pharmacokinetics  2023      DOI: 10.1016/j.dmpk.2023.100512
17779  Sansawat, A., Ratanacoon, M. and Nitteranon, V.  Antioxidative, anti-inflammatory, antibacterial, and anti- adhesive activities of different solvent extracts from various parts of Basella rubra L.  International Journal of Agricultural Technology  2023  19(2):655-668   
17780  Zhu Q, Iwai R, Okaguchi T, Shirasaka Y, Tamai I.  Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT  Food Funct  2023  May 2  PubMed ID: 37129213   DOI: 10.1039/d3fo00510k
19578  Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound  Deacylated Derivative of Hericenone C Treated by Lipase Shows Enhanced Neuroprotective Properties Compared to Its Parent Compound  Molecules  2023  28(11):4549  PubMed ID: 37299024   DOI: 10.3390/molecules28114549
19634  Tomii A, Higa M, Naito K, Kurata K, Kobayashi J, Takei C, Yuasa K, Koto Y, Shimizu H.  Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cells  Biosci Biotechnol Biochem  2023  87(8):839-849  PubMed ID: 37147026   DOI: 10.1093/bbb/zbad055
19662  Yusuke Takizawa, Naruya Kunii, Takanori Nakajima  Comparison of pharmaceutical characteristics and membrane permeability of truvada combination tablets and its generic drugs  Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector  2023  19    DOI: 10.1177/174113432311916
19704  Orita T, Chogahara S, Okuda M, Sakao K, Miyata T, Hou DX.  Extraction Efficiency and Alpha-Glucosidase Inhibitory Activities of Green Tea Catechins by Different Infusion Methods  Foods  2023  12(13):2611.  PubMed ID: 37444349   DOI: 10.3390/foods12132611
19835  Sugihara N, Okada Y, Tomioka A, Ito S, Tanemoto R, Nishii S, Mizoguchi A, Inaba K, Hanawa Y, Horiuchi K, Wada A, Akita Y, Higashiyama M, Kurihara C, Komoto S, Tomita K, Hokari R.  Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome  Gut Liver  2023  Jun 9  PubMed ID: 37291901   DOI: 10.5009/gnl220100
19840  Alghurabi H, Jassim Muhammad H, Tagami T, Ogawa K, Ozeki T.  Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid  Int J Pharm  2023  648:123597.  PubMed ID: 37952559   DOI: 10.1016/j.ijpharm.2023.123597
19883  Maruyama M, Yoshikata M, Sakaguchi M, Wakushima S, Higaki K.  Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs  Int J Pharm   2023  633:122617  PubMed ID: 36657552   DOI: 10.1016/j.ijpharm.2023.122617
19917  Ishioka K, Miyazaki N, Nishiyama K, Suzutani T.  Characterization of Lactococcus lactis 11/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic  Microorganisms   2023  11(12):2949  PubMed ID: 38138093   DOI: 10.3390/microorganisms11122949
19918  Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I.  Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation  Toxicol Mech Methods  2023  33(9):741-754  PubMed ID: 37496379   DOI: 10.1080/15376516.2023.2238061
19925  Mukai H, Takanashi M, Ogawara KI, Maruyama M, Higaki K.  Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers  J Pharm Sci  2023  S0022-3549(23)00486-0  PubMed ID: 37984697   DOI: 10.1016/j.xphs.2023.11.010
19943  Koyama Y, Fujihara S, Chiyo T, Matsui T, Hamaya S, Fujita K, Tani J, Morishita A, Kobara H, Ono M, Iwama H, Masaki T.  Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer  In Vivo  2023  37(5):1980-1990  PubMed ID: 37652512   DOI: 10.21873/invivo.13295
19959  Tamura S, Tazawa H, Hori N, Li Y, Yamada M, Kikuchi S, Kuroda S, Urata Y, Kagawa S, Fujiwara T.  p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells  PLoS One  2023  18(11):e0294491  PubMed ID: 37972012   DOI: 10.1371/journal.pone.0294491
13874  Yamada N, Negoro R, Watanabe K, Fujita T.  Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system  Drug Metab Pharmacokinet  2023  50:100497.  PubMed ID: 37037169   DOI: 10.1016/j.dmpk.2023.100497
21020  Kudo K, Kobayashi T, Kasai K, Nozaka H, Nakamura T.  Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α.  Biochem Biophys Res Commun  2023  642:185-191  PubMed ID: 36586186   DOI: 10.1016/j.bbrc.2022.12.051
21021  Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T.  Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.  Biochim Biophys Acta Mol Cell Res  2023  1870(2):119404  PubMed ID: 36535369   DOI: 10.1016/j.bbamcr.2022.119404
21182  Tsubaki M, Takeda T, Matsuda T, Kishimoto K, Takefuji H, Taniwaki Y, Ueda M, Hoshida T, Tanabe K, Nishida S.  Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy.  Cancer Cell Int  2023  23(1):73  PubMed ID: 37069612   DOI: 10.1186/s12935-023-02884-z
21203  Kuriya K, Goto S, Kobayashi E, Nishio M, Nakamura M, Umekawa H.  Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols.  Mol Biol Rep  2023    PubMed ID: 37160631   DOI: 10.1007/s11033-023-08481-7
21281  Lyu M, Bai Y, Orihara K, Miyanaga K, Yamamoto N.  GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions.  Microorganisms  2023  11(6)  PubMed ID: 37374895   DOI: 10.3390/microorganisms11061393
21285  Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E.  Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.  Biochem Biophys Res Commun  2023  672:72-80  PubMed ID: 37343317   DOI: 10.1016/j.bbrc.2023.06.017
21307  Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.  Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.  Ann Surg Oncol  2023    PubMed ID: 37407874   DOI: 10.1245/s10434-023-13779-8
21310  Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T.  Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.  J Gastroenterol  2023    PubMed ID: 37410250   DOI: 10.1007/s00535-023-02016-4
21358  Yamaguchi R, Kanie Y, Kazamaki T, Kanie O, Shimizu Y.  Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells.  Carbohydr Res  2023  532:108921  PubMed ID: 37562111   DOI: 10.1016/j.carres.2023.108921
21419  Shibamoto A, Kaji K, Nishimura N, Kubo T, Iwai S, Tomooka F, Suzuki J, Tsuji Y, Fujinaga Y, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.  Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin.  J Nutr Biochem  2023  109450  PubMed ID: 37777163   DOI: 10.1016/j.jnutbio.2023.109450
21424  Kataoka M, Kitazawa M, Nakamura S, Koyama M, Yamamoto Y, Miyazaki S, Hondo N, Tanaka H, Soejima Y.  Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment.  Anticancer Res  2023  43(10):4341-4348  PubMed ID: 37772552   DOI: 10.21873/anticanres.16629
21445  Cheng Y, Watanabe C, Ando Y, Kitaoka S, Egawa Y, Takashima T, Matsumoto A, Murakami M.  Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.  Pharmaceutics  2023  15(9)  PubMed ID: 37765306   DOI: 10.3390/pharmaceutics15092338
21455  Hiranphinyophat S, Hiraoka T, Kobayashi M, Fujii S, Kishida A, Tanabe T, Kimura T, Yamamoto M.  Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies.  Langmuir  2023    PubMed ID: 37882450   DOI: 10.1021/acs.langmuir.3c01858
21494  Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.  The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine.  Biol Pharm Bull  2023  46(12):1745-1752  PubMed ID: 38044133   DOI: 10.1248/bpb.b23-00479
21521  Kiba Y, Tanikawa T, Hayashi T, Kamauchi H, Seki T, Suzuki R, Kitamura M.  Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains.  Biomed Pharmacother  2023  169:115940  PubMed ID: 38007936   DOI: 10.1016/j.biopha.2023.115940
17506  Hashizume J, Sato K, Nakagawa H, Harasawa H, Honda T, Kodama Y.  Examination of the Effect of Proton Pump Inhibitors on the Anticancer Activity of Oxaliplatin  Cancer Diagn Progn  2022  2(6):620-626  PubMed ID: 36340458   DOI: 10.21873/cdp.10151
17564  Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells  Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells  Journal of Applied Pharmaceutical Science  2022  147-159    DOI: 10.7324/japs.2022.120715
17586  Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, Yamaji R.  Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide  J Agric Food Chem  2022  70(49):15499-15508  PubMed ID: 36458736   DOI: 10.1021/acs.jafc.2c06791
14784  Ariumi Y.  Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection  J Virol  2022  96(6):e0000222  PubMed ID: 35107372   DOI: 10.1128/jvi.00002-22
15564  Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T.  Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system  Arch Toxicol  2022  Oct 16  PubMed ID: 34654938   DOI: 10.1007/s00204-021-03175-0
20541  Shinji S, Shichi Y, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Yonaga K, Iwai T, Takeda K, Ueda K, Kuriyama S, Miyasaka T, Ueda Y, Sasaki N, Takahashi K, Ohashi R, Ishiwata T, Arai T, Yoshida H.  A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor  J Nippon Med Sch  2022  89(4):368-376  PubMed ID: 35082206   DOI: 10.1272/jnms.JNMS.2022_89-402
16347  Naoki Murata, Saki Keitoku, Hideo Miyake, Reiji Tanaka, Toshiyuki Shibata  Evaluation on Intestinal Permeability of Phlorotannins Using Caco-2 Cell Monolayers  Natural Product Communications  2022  17:1934578X2110704    DOI: 10.1177/1934578x211070415
16348  Inada A, Sawao A, Takahashi K, Oshima T.  Enhanced water dispersibility and Caco-2 cell monolayer permeability of quercetin by complexation with casein hydrolysate  J Food Sci  2022  87(3):1174-1183  PubMed ID: 35122241   DOI: 10.1111/1750-3841.16049
16349  Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S.  PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells  Oncol Lett  2022  23(4):106  PubMed ID: 35242234   DOI: 10.3892/ol.2022.13226
20603  Diao X, Yamada K, Shibata Y, Imada C.  Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide.  Mar Drugs  2022  20(2)  PubMed ID: 35200617   DOI: 10.3390/md20020087
20610  Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.  TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.  Biochem Biophys Rep  2022  30:101239  PubMed ID: 35252596   DOI: 10.1016/j.bbrep.2022.101239
20640  Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A.  Indigo plant leaf extract inhibits the binding of SARS-CoV-2 spike protein to angiotensin-converting enzyme 2.  Exp Ther Med  2022  23(4):274  PubMed ID: 35251340   DOI: 10.3892/etm.2022.11200
20686  Enomoto M, Kaji K, Nishimura N, Fujimoto Y, Murata K, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H.  Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.  Dig Liver Dis  2022    PubMed ID: 35514019   DOI: 10.1016/j.dld.2022.04.012
20699  Takahashi Y, Abe H, Koayama K, Koseki S.  Modeling the invasion of human small intestinal epithelial-like cells by Salmonella enterica Typhimurium and Listeria monocytogenes using Bayesian inference.  Lett Appl Microbiol  2022    PubMed ID: 35575530   DOI: 10.1111/lam.13738
16510  Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu  Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation  Toxicology Reports  2022  9:937-944  PubMed ID: 35875256   DOI: 10.1016/j.toxrep.2022.04.019
20749  Takizawa Y, Nakamura R, Kurita T, Nakajima T.  Lactose hydrate can increase the transcellular permeability of β-naphthol in rat jejunum and ileum.  Mol Biol Rep  2022    PubMed ID: 35767107   DOI: 10.1007/s11033-022-07709-2
16737  Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima  Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells  Scholars Academic Journal of Pharmacy  2022  11:60-66    DOI: 10.36347/sajp.2022.v11i04.002
16738  Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama  Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding  BPB Reports  2022  5:66-69    DOI: 10.1248/bpbreports.5.3_66
16739  Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.  Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles  J Biotechnol  2022  354:34-44  PubMed ID: 35724765   DOI: 10.1016/j.jbiotec.2022.06.006
16742  Kawahara T, Shimizu I, Tanaka Y, Tobita K, Tomokiyo M, Watanabe I.  Lactobacillus crispatus Strain KT-11 S-Layer Protein Inhibits Rotavirus Infection  Front Microbiol  2022  13:783879  PubMed ID: 35273580   DOI: 10.3389/fmicb.2022.783879
20798  Onuma S, Kinoshita S, Shimba S, Ozono K, Michigami T, Kawai M.  The lack of Bmal1, a core clock gene, in the intestine decreases glucose absorption in mice.  Endocrinology  2022    PubMed ID: 35904419   DOI: 10.1210/endocr/bqac119
20829  Sakakibara Y, Kojima A, Asai Y, Nadai M, Katoh M.  Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid.  Biopharm Drug Dispos  2022    PubMed ID: 36000181   DOI: 10.1002/bdd.2328
20956  Satow R, Suzuki Y, Asada S, Ota S, Idogawa M, Kubota S, Ikeo N, Yoneda A, Fukami K.  Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells.  iScience  2022  25(12):105501  PubMed ID: 36404918   DOI: 10.1016/j.isci.2022.105501
20966  Akino S, Yasujima T, Yamashiro T, Yuasa H.  Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter.  Life Sci Alliance  2022  6(2)  PubMed ID: 36456177   DOI: 10.26508/lsa.202201629
17777  Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima  The influence of 4-methylimidazole on the gastrointestinal epithelial cells  J. Excipients and Food Chem  2021  12:4-15   
12864  Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M.  Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy  Biol Trace Elem Res  2021  199(9):3272-3286  PubMed ID: 33236292   DOI: 10.1007/s12011-020-02463-7
20031  Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.  Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin.  Biol Pharm Bull  2021  44(2):275-278  PubMed ID: 33518681   DOI: 10.1248/bpb.b20-00644
13512  Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I.  Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase  mBio  2021  12(1):e01974-20  PubMed ID: 33563838   DOI: 10.1128/mBio.01974-20
13556  Zhu Q, Komori H, Imamura R, Tamai I.  A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT  J Pharm Sci  2021  110(3):1392-1400  PubMed ID: 33278408   DOI: 10.1016/j.xphs.2020.11.030
20064  Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S.  Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.  Eur J Pharmacol  2021  898:173957  PubMed ID: 33662352   DOI: 10.1016/j.ejphar.2021.173957
20066  Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y.  Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.  Lipids Health Dis  2021  20(1):24  PubMed ID: 33648494   DOI: 10.1186/s12944-021-01448-2
20080  Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T.  Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.  Int J Environ Res Public Health  2021  18(4)  PubMed ID: 33671655   DOI: 10.3390/ijerph18042126
20149  Igarashi F, Nakagawa T, Shinohara Y, Tachibana T.  Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.  Pharm Res  2021  Pharm Res  PubMed ID: 34009624   DOI: 10.1007/s11095-021-03054-4
14514  Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M.  An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement  PLoS One  2021  16(6):e0253066  PubMed ID: 34115818   DOI: 10.1371/journal.pone.0253066
14782  Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A.  MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2  Sci Rep  2021  11(1):5376  PubMed ID: 33686154   DOI: 10.1038/s41598-021-84882-7
14786  Sasaki M, Uemura K, Sato A, Toba S, Sanaki T, Maenaka K, Hall WW, Orba Y, Sawa H.  SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells  PLoS Pathog  2021  17(1):e1009233  PubMed ID: 33476327   DOI: 10.1371/journal.ppat.1009233
20226  Chowdhury MMI, Tomii A, Ishii K, Tahara M, Hitsuda Y, Koto Y, Kurata K, Yuasa K, Nishimura K, Shimizu H.  TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells.  Biosci Biotechnol Biochem  2021    PubMed ID: 34245564   DOI: 10.1093/bbb/zbab128
15106  Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N.  Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted fr  Food Chem  2021  360:129822  PubMed ID: 33984564   DOI: 10.1016/j.foodchem.2021.129822
15149  Gen Toshima, Takanobu Kiuchi, Yuka Iwama, Haruna Ohrui, Fumiko Kimura, Shiho Nakagawa, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata, Junichiro Takahashi  Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki)  Journal of Biological Macromolecules  2021  21:33-44    DOI: 10.14533/jbm.21.33
20270  Nguma E, Yamashita S, Kumagai K, Otoki Y, Yamamoto A, Eitsuka T, Nakagawa K, Miyazawa T, Kinoshita M.  Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress.  ACS Omega  2021  6(4):3140-3148  PubMed ID: 33553930   DOI: 10.1021/acsomega.0c05545
20293  Arai M, Komori H, Fujita D, Tamai I.  Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.  Pharm Res  2021  38(3):523-530  PubMed ID: 33723795   DOI: 10.1007/s11095-021-03018-8
20300  Kitazawa M, Miyagawa Y, Koyama M, Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu D, Takeoka M, Soejima Y.  Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL.  Mol Clin Oncol  2021  15(1):148  PubMed ID: 34094546   DOI: 10.3892/mco.2021.2310
15288  Akihiro Nishiguchi, Tetsushi Taguchi  Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis  Advanced Functional Materials  2021  2100548    DOI: 10.1002/adfm.202100548
15412  Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.  Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer  Cancer Sci  2021  112(8):3173-3189  PubMed ID: 34008277   DOI: 10.1111/cas.14969
20369  Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K.  Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells.  Mol Ther Nucleic Acids  2021    PubMed ID: 34692233   DOI: 10.1016/j.omtn.2021.10.016
20384  Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.  Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.  Mol Pharm  2021    PubMed ID: 34734526   DOI: 10.1021/acs.molpharmaceut.1c00490
15758  Suzuki T, Nagata M, Kagawa N, Takano S, Nahrowi, Nomura J.  Anti-Obesity Effects of Matoa ( Pometia pinnata) Fruit Peel Powder in High-Fat Diet-Fed Rats  Molecules  2021  26(21):6733  PubMed ID: 34771142   DOI: 10.3390/molecules26216733
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032   DOI: 10.1016/j.heliyon.2021.e08318
15879  Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.  5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2  iScience  2021  24(10):103120  PubMed ID: 34541466   DOI: 10.1016/j.isci.2021.103120
15881  Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS.  SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis  Nat Commun  2021  12(1):6602  PubMed ID: 34782627   DOI: 10.1038/s41467-021-26910-8
20468  Choeisoongnern T, Sirilun S, Waditee-Sirisattha R, Pintha K, Peerajan S, Chaiyasut C.  Potential Probiotic Enterococcus faecium OV3-6 and Its Bioactive Peptide as Alternative Bio-Preservation.  Foods  2021  10(10)  PubMed ID: 34681312   DOI: 10.3390/foods10102264
16102  Arung ET, Ramadhan R, Khairunnisa B, Amen Y, Matsumoto M, Nagata M, Kusuma IW, Paramita S, Sukemi, Yadi, Tandirogang N, Takemoto N, Syafrizal, Kim YU, Shimizu K.  Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines  Saudi J Biol Sci  2021  ;28(12):7182-7189  PubMed ID: 34867021   DOI: 10.1016/j.sjbs.2021.08.017
16123  Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M.  Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation  Front Oncol9  2021  11:70593  PubMed ID: 34595111   DOI: 10.3389/fonc.2021.705939
16137  Takashima Y, Ishikawa K, Miyawaki R, Ogawa M, Ishii T, Misaka T, Kobayashi S.  Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity  J Agric Food Chem  2021  69(33):9585-9596  PubMed ID: 34346218   DOI: 10.1021/acs.jafc.1c03483
16292  Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.  Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity  World J Gastroenterol  2021  27(48):8323-8342  PubMed ID: 35068872   DOI: 10.3748/wjg.v27.i48.8323
16367  Endo S, Nishiyama T, Matuoka T, Miura T, Nishinaka T, Matsunaga T, Ikari A.  Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells  Chem Biol Interact  2021  348:109634  PubMed ID: 34506768   DOI: 10.1016/j.cbi.2021.109634
16368  Komori H, Fujita D, Shirasaki Y, Zhu Q, Iwamoto Y, Nakanishi T, Nakajima M, Tamai I.  MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-Transporting Peptide 2B1/ SLCO2B1 in Caco-2 Cells  Drug Metab Dispos  2021  49(9):803-809  PubMed ID: 34162689   DOI: 10.1124/dmd.121.000380
16369  Abdelbasset Boubakri, Hanen Najjaa, Hanane Maghrebi, Abdelkarim Ben Arfa, Marcos Antonio Das Neves, Hiroko Isoda, Mitsutoshi Nakajima, Mohamed Neffati  Effect of freeze‐drying on the antioxidant and the cytotoxic properties of Allium roseum L. and its application in stabilizing food emulsions  Journal of Food Processing and Preservation  2021  45    DOI: 10.1111/jfpp.15389
16371  Nashimoto Y, Abe M, Fujii R, Taira N, Ida H, Takahashi Y, Ino K, Ramon-Azcon J, Shiku H.  Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies  Adv Healthc Mater  2021  10(21):e2101186  PubMed ID: 34409770   DOI: 10.1002/adhm.202101186
16373  Ito S, Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T.  Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing  Mater Sci Eng C Mater Biol Appl  2021  123:111993  PubMed ID: 33812615   DOI: 10.1016/j.msec.2021.111993
16728  YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung  Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells  Biodiversitas Journal of Biological Diversity  2021      DOI: 10.13057/biodiv/d220412
11781  Tachibana K, Kondoh M.  A Method to Prepare Claudin-Modulating Recombinant Proteins.  Methods Mol. Biol  2020  2109:251-260  PubMed ID: 31471875   DOI: 10.1007/7651_2019_258
11784  Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H.  α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation.  J. Cell. Biochem  2020  121(2):1238-1249  PubMed ID: 31478242   DOI: 10.1002/jcb.29357
11981  Kawahara T, Fujii K, Nakajima K, Fujii R, Inagaki S, Hara K, Yasui H.  Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells.  Planta Med.  2020    PubMed ID: 31896136   DOI: 10.1055/a-1078-7860
12099  Meparambu Prabhakaran D, Ramamurthy T, Thomas S.  Genetic and virulence characterisation of Vibrio parahaemolyticus isolated from Indian coast.  BMC Microbiol.  2020    PubMed ID: 32293257   DOI: 10.1186/s12866-020-01746-2
13047  Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N.  Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.  Bioorg Med Chem  2020    PubMed ID: 32616184   DOI: 10.1016/j.bmc.2020.115562
13091  Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.  Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.  Carbohydr Polym  2020    PubMed ID: 32829826   DOI: 10.1016/j.carbpol.2020.116698
13136  Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S.  10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.  Biol Pharm Bull  2020    PubMed ID: 32741940   DOI: 10.1248/bpb.b20-00101
13162  Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.  Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.  J Oleo Sci  2020    PubMed ID: 32788522   DOI: 10.5650/jos.ess20105
13201  Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y.  Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.  Int J Oncol  2020    PubMed ID: 32901840   DOI: 10.3892/ijo.2020.5117
13211  Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.  Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.  Biochem Biophys Rep  2020    PubMed ID: 32964147   DOI: 10.1016/j.bbrep.2020.100807
13234  Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32977947   DOI: 10.1016/j.bbrc.2020.09.007
13252  Yamashiro T, Yasujima T, Said HM, Yuasa H.  pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.  J Biol Chem  2020    PubMed ID: 33008889   DOI: 10.1074/jbc.RA120.013610
13289  Abe H, Koyama K, Koseki S.  Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.  Appl Environ Microbiol  2020    PubMed ID: 33067190   DOI: 10.1128/AEM.01551-20
13316  Nagata Y, Yamamoto T, Kadowaki M.  Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.  J Nutr Sci Vitaminol (Tokyo)  2020    PubMed ID: 33132350   DOI: 10.3177/jnsv.66.462
13449  Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi  Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph  BMC  2020      DOI: 10.21203/
13517  Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M.  Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route  J Membr Biol  2020  253(3):221-228  PubMed ID: 32328687   DOI: 10.1007/s00232-020-00118-1
13550  Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T.  Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice  Cancer Sci  2020  111(4):1193-1202  PubMed ID: 31997435   DOI: 10.1111/cas.14335
13574  Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M.  Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro  J Oleo Sci  2020  69(7):751-757  PubMed ID: 32612025   DOI: 10.5650/jos.ess20050
13620  Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.  Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats  Front Pharmacol  2020  11:1277  PubMed ID: 32922296   DOI: 10.3389/fphar.2020.01277
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13646  Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M.  Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids  Eur J Pharm Sci   2020  142:10514  PubMed ID: 31730802   DOI: 10.1016/j.ejps.2019.105144
13840  Nakajima T, Sasaki K, Yamamori A, Sakurai K, Miyata K, Watanabe T, Matsunaga YT.  A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays  Biomater Sci  2020  8(20):5615-5627  PubMed ID: 32945306   DOI: 10.1039/d0bm00763c
15260  Mu Y, Li J, Kang JH, Eto H, Zai K, Kishimura A, Hyodo F, Mori T, Katayama Y.  A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation  Biol Pharm Bull  2020  43(9):1413-1420  PubMed ID: 32879216   DOI: 10.1248/bpb.b20-00432
16823  Li Z, Zheng J, Luo X, Manabe Y, Hirata T, Sugawara T.  Absorption and Tissue Distribution of Siphonaxanthin from Green Algae  Mar Drugs  2020  18(6):291  PubMed ID: 32492769   DOI: 10.3390/md18060291
16825  Takahashi K, Orito N, Yanagisawa D, Yano A, Mori Y, Inoue N.  Eosinophils are the main cellular targets for oral gene delivery using Lactic acid bacteria  Vaccine  2020  38(17):3330-3338  PubMed ID: 32197922   DOI: 10.1016/j.vaccine.2020.02.084
17866  Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu  New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus  Phytochemistry Letters  2019  32:10-14    DOI: 10.1016/j.phytol.2019.04.017
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11386  Uchiyama H, Wada Y, Hatanaka Y, Hirata Y, Taniguchi M, Kadota K, Tozuka Y.  Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.  J Pharm Sci  2019    PubMed ID: 30653971   DOI: 10.1016/j.xphs.2019.01.007
11426  Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.  Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30739789   DOI: 10.1016/j.bbrc.2019.01.122
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11641  Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.  Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 31351225   DOI: 10.1016/j.bbalip.2019.07.010
11702  Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki  Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose  Natural Product Communications  2019      DOI: 10.1177/1934578X19883728
11825  Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.  Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.  Lipids  2019    PubMed ID: 31574565   DOI: 10.1002/lipd.12194
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6882  Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.  Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.  Cancer Sci  2019  110(12):3708-3717  PubMed ID: 31648389   DOI: 10.1111/cas.14221
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6940  Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.  Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.  Pharm Res  2019  37(1):13  PubMed ID: 31873817   DOI: 10.1007/s11095-019-2729-x
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6966  Matsuzaki T, Nakamura M, Nogita T, Sato A.  Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.  Biol Pharm Bull  2019  42(6):989-995  PubMed ID: 31155596   DOI: 10.1248/bpb.b19-00011
9418  Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome  Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha  iosci Microbiota Food Health  2019  38(1):11-22  PubMed ID: 30705798   DOI: 10.12938/bmfh.18-005
9414  Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2  CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin  Mol Cell Biol  2019  39(16):e00073-19  PubMed ID: 31160493   DOI: 10.1128/MCB.00073-19
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
10420  Sanae Yoshimoto, Keiko Okada, Osamu Hayashi  Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier  Functional Foods in Health and Disease  2019  9(7):466-483     DOI: 10.31989/ffhd.v9i7.611
10587  Selma Etteieb Jamila Tarhouni Hiroko Isoda  Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures  Water and Environment Journal  2019  33:4-13    DOI: 10.1111/wej.12361
10588  Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura  Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients  Journal of Functional Foods  2019  55:352-361    DOI: 10.1016/j.jff.2019.02.026
11913  Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.  Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.  Cancers (Basel)  2019    PubMed ID: 31769426   DOI: 10.3390/cancers11121866
12013  Matsumoto A, Watanabe C, Murakami M.  Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.  Drug Discov Ther  2019    PubMed ID: 31956233   DOI: 10.5582/ddt.2019.01090
12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389   DOI: 10.1371/journal.pone.0214000
12517  Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.  Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)  Nat Prod Res  2019  33(2):189-195  PubMed ID: 29457741   DOI: 10.1080/14786419.2018.1440229
10543  Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.  Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.  Biochim. Biophys. Acta  2018  1860:428-433  PubMed ID: 28988777   DOI: 10.1016/j.bbamem.2017.10.003
10556  Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.  Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.  Toxicol In Vitro  2018  46:284-293  PubMed ID: 29054700   DOI: 10.1016/j.tiv.2017.10.019
10580  Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.  Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.  Glycobiology  2018  28:21-31  PubMed ID: 29069492   DOI: 10.1093/glycob/cwx088
10656  Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.  Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.  Arch. Biochem. Biophys.  2018  638:58-65  PubMed ID: 29242061   DOI: 10.1016/
10665  Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.  The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.  Oncogene  2018  37:1205-1219  PubMed ID: 29242607   DOI: 10.1038/s41388-017-0033-y
10681  Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.  Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.  Exp. Anim.  2018  67:201-218  PubMed ID: 29276215   DOI: 10.1538/expanim.17-0112
10794  Numata T, Sato-Numata K, Okada Y, Inoue R.  Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.  J Nat Med  2018  72:694-705  PubMed ID: 29569221   DOI: 10.1007/s11418-018-1207-9
11102  Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.  A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.  Sci Rep  2018  8(1):9008  PubMed ID: 29899364   DOI: 10.1038/s41598-018-27408-y
11130  Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.  Probiotics in human gut microbiota can degrade host glycosaminoglycans.  Sci Rep  2018  8(1):10674  PubMed ID: 30006634   DOI: 10.1038/s41598-018-28886-w
11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033   DOI: 10.1021/acs.molpharmaceut.8b00921
4174  Sakuta Y, Takehara I, Tsunoda KI, Sato K.  Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.  Anal Sci  2018    PubMed ID: 29806615   DOI: 10.2116/analsci.18P141
4472  Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.  Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.  Inflamm. Res.  2018  67(11-12):975-984  PubMed ID: 30317465   DOI: 10.1007/s00011-018-1193-0
4473  Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.  Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo.  Biol. Pharm. Bull.  2018  41(2):190-197  PubMed ID: 29386479   DOI: 10.1248/bpb.b17-00657
9492  Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown  TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma  Oncotarget  2018  9(26):18480-18493  PubMed ID: 29719619   DOI: 10.18632/oncotarget.24883
9909  Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.  Role of CXC chemokine receptor type 4 as a lactoferrin receptor.  Biochem. Cell Biol.  2017  95:57-63  PubMed ID: 28075616   DOI: 10.1139/bcb-2016-0039
10056  Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.  miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.  BMC Cancer  2017  17:33  PubMed ID: 28061765   DOI: 10.1186/s12885-016-3003-9
10091  Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.  Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.  Biochem. Biophys. Res. Commun.  2017  484:543-549  PubMed ID: 28130106   DOI: 10.1016/j.bbrc.2017.01.114
10167  Takahashi K, Suzuki N, Ogra Y.  Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.  Int J Mol Sci  2017  18:  PubMed ID: 28245633   DOI: 10.3390/ijms18030506
10214  Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.  Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.  Eur. J. Pharmacol.  2017  804:46-51  PubMed ID: 28327343   DOI: 10.1016/j.ejphar.2017.03.041
10227  Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.  Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.  J. Food Sci.  2017  82:1224-1230  PubMed ID: 28346686   DOI: 10.1111/1750-3841.13680
10247  Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y.  Carnosine activates the CREB pathway in Caco-2 cells.  Cytotechnology  2017  69:523-527  PubMed ID: 28374107   DOI: 10.1007/s10616-017-0089-0
10319  Nakayama T, Funakoshi-Tago M, Tamura H.  Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.  Oncol Lett  2017  14:1109-1114  PubMed ID: 28693281   DOI: 10.3892/ol.2017.6227
10325  Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.  Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.  Toxicol. Lett.  2017  277:18-23  PubMed ID: 28552774   DOI: 10.1016/j.toxlet.2017.05.012
10474  Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.  Biochem. Pharmacol.  2017  145:192-201  PubMed ID: 28843775   DOI: 10.1016/j.bcp.2017.08.016
10552  Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293   DOI: 10.1142/S0192415X17500811
10635  Yamashita S, Seino T, Aida K, Kinoshita M.  Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.  J Oleo Sci  2017  66:1337-1342  PubMed ID: 29199207   DOI: 10.5650/jos.ess17171
10976    Effect of luteolin on the expression of intestinal cholesterol transporters  Journal of Functional Foods  2017  36:274-279    DOI: 10.1016/j.jff.2017.07.008
10979    1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis  Nutrition Research  2017  46, 59-67  PubMed ID: 28931466   DOI: 10.1016/j.nutres.2017.07.005
10996    Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells  Journal of Functional Foods  2017  39, 91-95    DOI: 10.1016/j.jff.2017.10.013
10999    Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity  Food Science and Technology Research  2017  23, 725-732    DOI: 10.3136/fstr.23.725
4194  Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.  A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.  Lab Chip  2017    PubMed ID: 29184959   DOI: 10.1039/c7lc00952f
10008  Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto  Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers  J Clin Biochem Nutr  2017  60(2):81-85  PubMed ID: 28366985   DOI: 10.3164/jcbn.16-32
10019  Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga  Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes  Biochem Biophys Res Commun  2017  486(1):143-148  PubMed ID: 28285137   DOI: 10.1016/j.bbrc.2017.03.014
10025  Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita  Design and fabrication of devices for investigating cell-sheet stretch  BioChip Journal  2017  11:173–179    DOI: 10.1007/s13206-017-1301-1
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625   DOI: 10.3892/ijo.2017.3859
10035  Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari   Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity  J Gastroenterol Hepatol  2017  32(11):1839-1845  PubMed ID: 28295549   DOI: 10.1111/jgh.13785
9931  Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito  Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications  Front Physiol  2017  8:997  PubMed ID: 29259558   DOI: 10.3389/fphys.2017.00997
14774  Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism  Kidney Int  2017  91(3):658-670  PubMed ID: 27988213   DOI: 10.1016/j.kint.2016.09.041
7107  Yamazoe H, Ichikawa T, Hagihara Y, Iwasaki Y.  Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.  Acta Biomater  2016  31:231-240  PubMed ID: 26685756   DOI: 10.1016/j.actbio.2015.12.016
9508  Kaku Y, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T.  HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.  Anticancer Res.  2016  36:39-48  PubMed ID: 26722026  
9525  Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T.  Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.  Int. J. Oncol.  2016  48:1297-304  PubMed ID: 26783196   DOI: 10.3892/ijo.2016.3332
9544  Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.  Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.  Sci Rep  2016  7:20069  PubMed ID: 26822058   DOI: 10.1038/srep20069
9580  Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K.  Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.  J Nat Med  2016  70:661-6  PubMed ID: 26899240   DOI: 10.1007/s11418-016-0976-2
9590  Jdir H, Khemakham B, Najjaa H, Chakroun M, Jridi M, Ben Arfa A, Ben Ali Y, Zouari N.  Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex.  Pharm Biol  2016  54:2111-8  PubMed ID: 26916801   DOI: 10.3109/13880209.2016.1145704
9638  Kaze N, Watanabe Y, Sato H, Murota K, Kotaniguchi M, Yamamoto H, Inui H, Kitamura S.  Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters.  Lipids  2016  51:913-22  PubMed ID: 27023203   DOI: 10.1007/s11745-016-4143-z
9646  Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T.  Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.  J. Biol. Chem.  2016  291:12586-600  PubMed ID: 27053111   DOI: 10.1074/jbc.M116.717561
9688  Kimura O, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y, Endo T.  Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers.  J. Pharm. Pharmacol.  2016  68:883-9  PubMed ID: 27166429   DOI: 10.1111/jphp.12557
9699  Kudo M, Katayoshi T, Kobayashi-Nakamura K, Akagawa M, Tsuji-Naito K.  H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.  Biochem. Biophys. Res. Commun.  2016  475:335-41  PubMed ID: 27216463   DOI: 10.1016/j.bbrc.2016.05.093
10030  Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y.  Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.  Oxid Med Cell Longev  2016  2016:2927131  PubMed ID: 27840668   DOI: 10.1155/2016/2927131
10884    Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water  Water, Air, & Soil Pollution  2016  227:341    DOI: 10.1007/s11270-016-3049-y
5810  Kitagawa N et al  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.  Int J Mol Sci  2016  17(12). pii: E1979  PubMed ID: 27898032   DOI: 10.3390/ijms17121979
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591   DOI: 10.1371/journal.pone.0147957
9989  Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa  The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro  J Vet Med Sci  2016  78(4):627-32  PubMed ID: 26685883   DOI: 10.1292/jvms.15-0595
10107  Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone  Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells  Nutr Res .  2016  36(11):1269-1276  PubMed ID: 27865621   DOI: 10.1016/j.nutres.2016.10.001
10108  Katsuya Narumi, Masaki Kobayashi, Ayuko Kondo, Ayako Furugen, Takehiro Yamada, Natsuko Takahashi, Ken Iseki  Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen  Biopharm Drug Dispos   2016  7(8):447-455  PubMed ID: 27514365   DOI: 10.1002/bdd.2026
10110  Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara  An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1  Biol Pharm Bull .   2016  39(3):301-7  PubMed ID: 26934923   DOI: 10.1248/bpb.b15-00359
10111  Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu  New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi  Phytochemistry Letters  2016  17:64-70    DOI: 10.1016/j.phytol.2016.07.024
12897  Iwazaki A, Takahashi N, Miyake R, Hiroshima Y, Abe M, Yasui A, Imai K.  Effect of dietary fibers on losartan uptake and transport in Caco-2 cells  Biopharm Drug Dispos  2016  37(4):212-9  PubMed ID: 26748460   DOI: 10.1002/bdd.2004
14091  Gakuro Harada, Pawat Pattarawat, Kenji Ito, Takashi Matsumoto, Takanori Hasegawa, Yoshinori Katakura  Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1  Journal of Functional Foods  2016  23:444-452    DOI: 10.1016/j.jff.2016.01.016
14133  Guo L, Yamashita H, Kou I, Takimoto A, Meguro-Horike M, Horike S, Sakuma T, Miura S, Adachi T, Yamamoto T, Ikegawa S, Hiraki Y, Shukunami C.  Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation  PLoS Genet  2016  12:e1005802  PubMed ID: 26820155   DOI: 10.1371/journal.pgen.1005802
7117  Shimizu T, Ichimura K, Noda M.  The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.  Infect. Immun.  2015  84:537-49  PubMed ID: 26644384   DOI: 10.1128/IAI.00881-15
7203  Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T.  The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus.  FEMS Microbiol. Lett.  2015  362:  PubMed ID: 26394644   DOI: 10.1093/femsle/fnv173
7295  Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K.  Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.  Biochem. Pharmacol.  2015  97:89-98  PubMed ID: 26119820   DOI: 10.1016/j.bcp.2015.06.021
7414  Kaku Y, Tsuchiya A, Kanno T, Nishizaki T.  Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.  Pharmacology  2015  95:154-9  PubMed ID: 25833236   DOI: 10.1159/000381029
7419  Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A.  Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.  Int. J. Mol. Med.  2015  35:1603-9  PubMed ID: 25816245   DOI: 10.3892/ijmm.2015.2156
7436  Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S.  Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum.  Physiol Rep  2015  3:  PubMed ID: 25780093   DOI: 10.14814/phy2.12327
7574  Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA  Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.  Deep Ocean Water Research  2015  15:117-124   
9472  Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura  Enhanced Oleate Uptake and Lipotoxicity Associated With Laurate  FEBS Open Bio . 2015 May 29;5:485-91  2015  5:485-91  PubMed ID: 26106523   DOI: 10.1016/j.fob.2015.05.008
10118  Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura  Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice  Exp Cell Res  2015  331(2):408-15  PubMed ID: 25542842   DOI: 10.1016/j.yexcr.2014.12.007
10149  Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto    Jpn J Pharm Health Care Sci  2015  41(4): 236―243    DOI: 10.5649/jjphcs.41.236
10150  Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa  Sustained Inhibition of Proton-Coupled Folate Transporter by Myricetin  Drug Metab Pharmacokinet  2015  30(2):154-9.  PubMed ID: 25801697   DOI: 10.1016/j.dmpk.2014.11.001
10151  Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato  Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life  Eur J Pharm Sci  2015  67:136-143  PubMed ID: 25433245   DOI: 10.1016/j.ejps.2014.11.005
10152  Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki  Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy  J Control Release  2015  210:19-25  PubMed ID: 25998050   DOI: 10.1016/j.jconrel.2015.05.275
9993  Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami  Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption  J Nutr Sci Vitaminol (Tokyo)   2015  61(6):449-54  PubMed ID: 26875485   DOI: 10.3177/jnsv.61.449
10154  Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab  Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines   Energy Procedia  2015  74:878 – 885     DOI: 10.1016/j.egypro.2015.07.823
10156  Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe  Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity  J Ethnopharmacol  2015  161:147-55  PubMed ID: 25523370   DOI: 10.1016/j.jep.2014.12.009
10157  Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano  The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells  J Cell Mol Med  2015  19(7):1569-81  PubMed ID: 25689483   DOI: 10.1111/jcmm.12531
10158  Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida  Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer  Mol Clin Oncol  2015  3(5):1080-1084  PubMed ID: 26623054   DOI: 10.3892/mco.2015.577
10159  Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota  Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas  Oncology  2015  88(5):309-19  PubMed ID: 25591719   DOI: 10.1159/000369905
10160  Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa  Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation  J Biol Chem  2015  ;290(28):17439-50  PubMed ID: 26023238   DOI: 10.1074/jbc.M114.594937
10172  Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham  Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats  Nanomedicine  2015  11(5):1227-36  PubMed ID: 25725490   DOI: 10.1016/j.nano.2015.02.003
14459  Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.  MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells  PLoS One  2015  10(5):e0127119  PubMed ID: 25970424   DOI: 10.1371/journal.pone.0127119
15177  Ozeki K, Kato M, Sakurai Y, Ishigai M, Kudo T, Ito K.  Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study  Int J Pharm  2015  495(2):963-71  PubMed ID: 26387619   DOI: 10.1016/j.ijpharm.2015.09.035
17443  Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T.  An on-chip small intestine-liver model for pharmacokinetic studies  J Lab Autom  2015  20(3):265-73  PubMed ID: 25385717   DOI: 10.1177/2211068214557812
17455  Shimozato O, Waraya M, Nakashima K, Souda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T.  Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation  Oncogene  2015  34(15):1949-60  PubMed ID: 24882578   DOI: 10.1038/onc.2014.141
10196  Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi  Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats  PLoS One   2014  9(5):e97901  PubMed ID: 24859282   DOI: 10.1371/journal.pone.0097901
10198  Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo  Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells  Food Chem  2014  154:145-50  PubMed ID: 24518326   DOI: 10.1016/j.foodchem.2013.12.069
10199  Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo  Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells  Pestic Biochem Physiol .  2014  111:38-42  PubMed ID: 24861932   DOI: 10.1016/j.pestbp.2014.04.002
10202  Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki  Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells  Biol Pharm Bull  2014  37(3):490-2  PubMed ID: 24583869   DOI: 10.1248/bpb.b13-00700
10203  Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi  Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO)  Life Sci .   2014  107(1-2):14-20  PubMed ID: 24792517   DOI: 10.1016/j.lfs.2014.04.026
10204  Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo  Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters  Biol Pharm Bull .   2014  37(9):1475-9  PubMed ID: 25177030   DOI: 10.1248/bpb.b14-00219
10208  Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani  Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption  Drug Metab Pharmacokinet  2014  29(5):414-8  PubMed ID: 24806820   DOI: 10.2133/dmpk.dmpk-14-rg-001
10209  Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura  Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation  FEBS Lett .   2014  588(11):1997-2002  PubMed ID: 24792722   DOI: 10.1016/j.febslet.2014.04.025
10223  Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto  Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases  Cancer Chemother Pharmacol  2014  74(5):1023-8  PubMed ID: 25205428   DOI: 10.1007/s00280-014-2578-6
10224  Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto  Induction of AhR-mediated Gene Transcription by Coffee  PLoS One  2014  9(7):e102152  PubMed ID: 25007155   DOI: 10.1371/journal.pone.0102152
10225  Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa  Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin  Drug Metab Pharmacokinet  2014  29(4):312-6  PubMed ID: 24492671   DOI: 10.2133/dmpk.dmpk-13-rg-107
10226  Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki  Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion  J Pharm Pharm Sci  2014  17(2):266-76  PubMed ID: 24934555   DOI: 10.18433/j3jg7d
10229  Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto  Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin  Biopharm Drug Dispos  2014  35(6):321-9  PubMed ID: 24801141   DOI: 10.1002/bdd.1900
10237  Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi  Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures  Tumour Biol  2014  35(12):12689-93  PubMed ID: 25217322   DOI: 10.1007/s13277-014-2593-6
10242  T Nakayama, K Ezoe  Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O  Curr Microbiol .  2014  69(5):690-8  PubMed ID: 24974216   DOI: 10.1007/s00284-014-0639-z
10243  Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki  Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke  Sci Technol Adv Mater  2014  15(3):035002  PubMed ID: 27877678   DOI: 10.1088/1468-6996/15/3/035002
10244  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto  Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation  Immunol Cell Biol  2014  92(7):624-30  PubMed ID: 24777307   DOI: 10.1038/icb.2014.31
10254  Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi  Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells  J Clin Biochem Nutr  2014  55(3):162-7  PubMed ID: 25411520   DOI: 10.3164/jcbn.14-25
10259  Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure  Electric Stimulus Opens Intercellular Spaces in Skin  J Biol Chem  2014  24;289(4):2450-6  PubMed ID: 24318878   DOI: 10.1074/jbc.M113.514414
10262  Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane  Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D  FEMS Microbiol Lett  2014  2014 Aug;357(2):115-22  PubMed ID: 25041523   DOI: 10.1111/1574-6968.12527
6429  Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.  Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.  Biochim Biophys Acta  2013  1832(1):151-9  PubMed ID: 23064287   DOI: 10.1016/j.bbadis.2012.10.006
12694  Isshiki M, Ohta H, Tamura H.  Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells  Biol Pharm Bull  2013  36(2):299-304  PubMed ID: 23370358   DOI: 10.1248/bpb.b12-00902
12695  Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H.  Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells  J Pharm Pharmacol  2013  65(1):22-9  PubMed ID: 23215684   DOI: 10.1111/j.2042-7158.2012.01569.x
12696  Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K.  An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells  3 Biotech  2013  3(3):213-218  PubMed ID: 28324370   DOI: 10.1007/s13205-012-0085-1
12697  Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J.  Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1  World J Gastroenterol  2013  19(33):5500-7  PubMed ID: 24023493   DOI: 10.3748/wjg.v19.i33.5500
12698  Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H.  Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes  Biol Pharm Bull  2013  36(11):1862-6  PubMed ID: 24189430   DOI: 10.1248/bpb.b13-00471
12699  Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.  Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation  J Biol Chem  2013  288(19):13317-24  PubMed ID: 23532847   DOI: 10.1074/jbc.M113.459875
12700  Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.  INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors  Biochem Biophys Res Commun  2013  432(4):586-92  PubMed ID: 23438439   DOI: 10.1016/j.bbrc.2013.02.042
12701  Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J.  Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery  Eur J Pharm Sci  2013  50(3-4):303-11  PubMed ID: 23896171   DOI: 10.1016/j.ejps.2013.07.010
12702  Kamishikiryo J, Matsumura R, Takamori T, Sugihara N.  Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid  J Pharm Pharmacol  2013  65(7):1037-43  PubMed ID: 23738731   DOI: 10.1111/jphp.12062
12703  Kimura R, Rokkaku T, Takeda S, Senba M, Mori N.  Cytotoxic effects of fucoidan nanoparticles against osteosarcoma  Mar Drugs  2013  11(11):4267-78  PubMed ID: 24177673   DOI: 10.3390/md11114267
12704  Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.  Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections  Microb Pathog  2013  65:14-20  PubMed ID: 24036179   DOI: 10.1016/j.micpath.2013.08.006
12705  Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N.  Dlg5 interacts with the TGF-β receptor and promotes its degradation  FEBS Lett  2013  587(11):1624-9  PubMed ID: 23624079   DOI: 10.1016/j.febslet.2013.04.015
12706  Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K.  Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides  Int Immunopharmacol  2013  17(4):1009-19  PubMed ID: 24126111   DOI: 10.1016/j.intimp.2013.09.023
12693  Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.  Possible involvement of Wnt11 in colorectal cancer progression  Mol Carcinog   2013  52(3):207-17  PubMed ID: 22161723   DOI: 10.1002/mc.21845
15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110
15924  KATSUHITO ARAI – TAMIKO YAMAZAKI – YOSHIHIKO TOKUJI – MIKA KAWAHARA – KIYOSHI OHBA – KAZUNORI HIRONAKA – MIKIO KINOSHITA – MASAO OHNISHI  Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice  Journal of Food and Nutrition Research  2013  52:139–145   
15925  Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S.  Relationship between methyl CpG binding protein 2 and JC viral proteins  Jpn J Infect Dis  2013  66(2):126-32.  PubMed ID: 23514909   DOI: 10.7883/yoken.66.126
7607  Kimura O, Tsukagoshi K, Hayasaka M, Endo T.  Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.  Basic Clin. Pharmacol. Toxicol.  2012  110:530-6  PubMed ID: 22181038   DOI: 10.1111/j.1742-7843.2011.00850.x
7625  Ito N, Ohtsubo T, Kusu F, Hakamata H.  An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells.  Anal. Biochem.  2012  421:86-91  PubMed ID: 22119071   DOI: 10.1016/j.ab.2011.10.051
6316  Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F.  Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.  Int J Oncol  2012  40(1):217-26  PubMed ID: 21901246   DOI: 10.3892/ijo.2011.1189
10981  Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto  Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells  J Med Food  2012  15(6):511-9  PubMed ID: 22510151   DOI: 10.1089/jmf.2012.0040
12711  Kimura O, Tsukagoshi K, Hayasaka M, Endo T.  Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells  Arch Toxicol  2012  86(1):55-61  PubMed ID: 21766207   DOI: 10.1007/s00204-011-0734-x
12712  Yanagihara S, Hirota T, Yamamoto N.  Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells  J Biosci Bioeng  2012  114(6):582-5  PubMed ID: 22841868   DOI: 10.1016/j.jbiosc.2012.07.001
12713  Matsuo Y, Miyoshi Y, Okada S, Satoh E.  Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri  Biosci Microbiota Food Health  2012  31(4):93-102  PubMed ID: 24936355   DOI: 10.12938/bmfh.31.93
12714  Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M.  CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer  Eur J Cancer  2012  48(14):2244-51.  PubMed ID: 22197219   DOI: 10.1016/j.ejca.2011.11.032
12715  Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K.  Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins  Acta Med Okayama  2012  66(3):253-61  PubMed ID: 22729106   DOI: 10.18926/AMO/48565
12716  Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K.  Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein  J Pharm Pharm Sci  2012  15(2):256-64  PubMed ID: 22579005   DOI: 10.18433/j38k56
12722  Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.  Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine  J Sci Food Agric  2012  92(4):857-61  PubMed ID: 21969243   DOI: 10.1002/jsfa.4658
12724  Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M.  Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients  Ann Surg Oncol  2012  19 Suppl 3:S518-27  PubMed ID: 21845497   DOI: 10.1245/s10434-011-1993-8
12729  Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K.  Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP  J Pharm Pharm Sci  2012  15(2):295-304  PubMed ID: 22579008   DOI: 10.18433/j3w896
12731  Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO  Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu”  Food Science and Technology Research  2012  18:825-834    DOI: 10.3136/fstr.18.825
12732  Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N.  Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate  J Food Sci  2012  77(10):H208-15  PubMed ID: 22938538   DOI: 10.1111/j.1750-3841.2012.02902.x
12733  Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.  A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers  Biol Pharm Bull  2012  35(1):1-9  PubMed ID: 22223330   DOI: 10.1248/bpb.35.1
12740  Chaisowwong W, Kusumoto A, Hashimoto M, Harada T, Maklon K, Kawamoto K.  Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat  J Vet Med Sci  2012  74(1):43-50  PubMed ID: 21891974   DOI: 10.1292/jvms.11-0305
16159  Megumi Ishimura, Mika Sakurai-Yageta, Tomoko Maruyama, Tomoko Ando, Masashi Fukayama, Akiteru Goto, Yoshinori Murakami  Involvement of miR-214 and miR-375 in Malignant Features of Non-Small-Cell Lung Cancer by Down-Regulating CADM1  Journal of Cancer Therapy  2012  03:379-387    DOI: 10.4236/jct.2012.324050
7622  Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.  Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.  Biol. Pharm. Bull.  2011  34:1885-9  PubMed ID: 22130247   DOI: 10.1248/bpb.34.1885
7653  Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M.  Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum.  Biomed. Res.  2011  32:313-20  PubMed ID: 22033300   DOI: 10.2220/biomedres.32.313
7668  Isshiki M, Umezawa K, Tamura H.  Coffee induces breast cancer resistance protein expression in Caco-2 cells.  Biol. Pharm. Bull.  2011  34:1624-7  PubMed ID: 21963506   DOI: 10.1248/bpb.34.1624
7735  Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M.  Isolation and characterization of a novel short peptide associated with Crohn's disease.  Clin. Exp. Immunol.  2011  166:72-9  PubMed ID: 21797848   DOI: 10.1111/j.1365-2249.2011.04444.x
7749  Ashida N, Yanagihara S, Shinoda T, Yamamoto N.  Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.  J. Biosci. Bioeng.  2011  112:333-7  PubMed ID: 21763196   DOI: 10.1016/j.jbiosc.2011.06.001
7783  Kimura O, Kotaki Y, Hamaue N, Haraguchi K, Endo T.  Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.  Food Chem. Toxicol.  2011  49:2167-71  PubMed ID: 21672599   DOI: 10.1016/j.fct.2011.06.001
7820  Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y.  Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.  Biopharm Drug Dispos  2011  32:253-60  PubMed ID: 21567399   DOI: 10.1002/bdd.755
7988  Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.  Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.  J. Agric. Food Chem.  2011  59:1470-6  PubMed ID: 21226458   DOI: 10.1021/jf103820b
8039  Tsuruta H, Yagishita T, Shimizu M, Tamura H.  Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2.  Toxicol In Vitro  2011  25:500-4  PubMed ID: 21144891   DOI: 10.1016/j.tiv.2010.12.002
8051  Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.  Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.  J. Biol. Chem.  2011  286:2750-61  PubMed ID: 21084306   DOI: 10.1074/jbc.M110.171504
18940  Norikura T, Fujiwara K, Narita T, Yamaguchi S, Morinaga Y, Iwai K, Matsue H.  Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta  J Agric Food Chem  2011  59(13):6974-9  PubMed ID: 21630659   DOI: 10.1021/jf200461j
9083  Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai  Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis  Infect Immun  2011  79 (11), 4353-60  PubMed ID: 21911469   DOI: 10.1128/IAI.05677-11
9085  Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda  Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli  Gene  2011  478 (1-2), 1-10  PubMed ID: 21262333   DOI: 10.1016/j.gene.2011.01.006
12742  Takeda S, Yamasaki K, Takeshita M, Kikuchi Y, Tsend-Ayush C, Dashnyam B, Ahhmed AM, Kawahara S, Muguruma M.  The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products  Anim Sci J  2011  82(4):571-9  PubMed ID: 21794017   DOI: 10.1111/j.1740-0929.2011.00874.x
12744  Okumura S, Saitoh H, Ishikawa T, Inouye K, Mizuki E.  Mode of action of parasporin-4, a cytocidal protein from Bacillus thuringiensis  Biochim Biophys Acta  2011  1808(6):1476-82  PubMed ID: 21073856   DOI: 10.1016/j.bbamem.2010.11.003
15705  Masayuki TAKEUCHI, Katsuki OHTANI, Yanju MA, Sanae KATO, Shingo SEMBA, Tsuyoshi KATOH, Nobutaka WAKAMIYA, Takanobu TANIGUCHI  Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lin  Food Science and Technology Research  2011  17:515-521    DOI: 10.3136/fstr.17.515
16160  Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K.  In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid  Int J Pharm  2011  403(1-2):136-8  PubMed ID: 20933071   DOI: 10.1016/j.ijpharm.2010.09.035
8119  Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M.  Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy.  JPEN J Parenter Enteral Nutr  2010  34:530-7  PubMed ID: 20852181   DOI: 10.1177/0148607110362694
8137  Wang C, Ho PC, Lim LY.  Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells.  Int J Pharm  2010  400:201-10  PubMed ID: 20804835   DOI: 10.1016/j.ijpharm.2010.08.023
8144  Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.  Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition  Cell. Physiol. Biochem.  2010  26:125-34  PubMed ID: 20798496   DOI: 10.1159/000320518
8156  Watanabe K, Kamata K, Sato J, Takahashi T.  Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption.  J Ethnopharmacol  2010  132:193-9  PubMed ID: 20713144   DOI: 10.1016/j.jep.2010.08.014
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387   DOI: 10.1038/sj.bjc.6605786
8386  Takahashi T, Kaku T, Sato T, Watanabe K, Sato J.  Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2.  J Nat Med  2010  64:55-62  PubMed ID: 20091240   DOI: 10.1007/s11418-009-0371-3
8429  Narita K, Kawate T, Kakinuma N, Takeda S.  Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium.  Traffic  2010  11:287-301  PubMed ID: 19958467   DOI: 10.1111/j.1600-0854.2009.01016.x
18483  Imura Y, Sato K, Yoshimura E.  Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity  Anal Chem  2010  82(24):9983-8  PubMed ID: 21090751   DOI: 10.1021/ac100806x
12749  Shirou Itagaki et al.  Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2  Food Chemistry  2010  120(2):552-555    DOI: 10.1016/j.foodchem.2009.10.052
12766  Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.  Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer   Cell Physiol Biochem  2010  54(8):1182-91  PubMed ID: 20112302   DOI: 10.1002/mnfr.200900348
12751  Nagamatsu Y, Okamura S, Saitou H, Akao T, Mizuki E.  Three Cry toxins in two types from Bacillus thuringiensis strain M019 preferentially kill human hepatocyte cancer and uterus cervix cancer cells  Biosci Biotechnol Biochem  2010  74(3):494-8  PubMed ID: 20208360   DOI: 10.1271/bbb.90615
12752  Mari Takaai, Jumpei Sakata, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto  Mechanisms for Transport of Methotrexate across Apical and Basolateral Membranes in Human Intestinal Epithelial Caco-2 Cells  ryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)  2010  36:63    DOI: 10.5649/jjphcs.36.63
12753  Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y, Nishimura Y.  The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy  Int J Cancer  2010  126(9):2153-63  PubMed ID: 19688828   DOI: 10.1002/ijc.24836
15672  Yamasaki T, Kawamura K, Hatori A, Yui J, Yanamoto K, Yoshida Y, Ogawa M, Nengaki N, Wakisaka H, Fukumura T, Zhang MR.  PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein  Nucl Med Commun  2010  31(11):985-93  PubMed ID: 20859232   DOI: 10.1097/MNM.0b013e32833fbf87
8476  Yamanashi Y, Takada T, Suzuki H.  In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.  Pharmacogenet. Genomics  2009  19:884-92  PubMed ID: 19823104   DOI: 10.1097/FPC.0b013e3283327925
8512  Yoshimura S, Kawano K, Matsumura R, Sugihara N, Furuno K.  Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.  J. Biomed. Biotechnol.  2009  2009:467489  PubMed ID: 19688110   DOI: 10.1155/2009/467489
8569  Kimura O, Tsukagoshi K, Endo T.  Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters.  Toxicol. Lett.  2009  189:102-9  PubMed ID: 19465094   DOI: 10.1016/j.toxlet.2009.05.006
8666  Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T.  Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors.  J. Gastroenterol.  2009  44:56-65  PubMed ID: 19159073   DOI: 10.1007/s00535-008-2273-7
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655   DOI: 10.3945/jn.108.092528
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
12761  Sugawara T, Yamashita K, Asai A, Nagao A, Shiraishi T, Imai I, Hirata T.  Esterification of xanthophylls by human intestinal Caco-2 cells  Arch Biochem Biophys  2009  483(2):205-12  PubMed ID: 18952044   DOI: 10.1016/
12762  Ishida K, Taguchi M, Akao T, Hashimoto Y.  Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells  Biol Pharm Bull   2009  32(3):513-6  PubMed ID: 19252307   DOI: 10.1248/bpb.32.513
12763  Kazuhiro Yamamoto, Hideki Hakamata, Akira Yamaguchi, Fumiyo Kusu  An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers  Anal Bioanal Chem  2009  395(2):533-8  PubMed ID: 19641905   DOI: 10.1007/s00216-009-2976-5
12765  Fukumori S, Masago M, Ishida K, Kayano Y, Taguchi M, Hashimoto Y.  Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells  Biopharm Drug Dispos  2009  30(8):448-56  PubMed ID: 19725017   DOI: 10.1002/bdd.679
12773  Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y.  Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma  Biochem Biophys Res Commun  2009  383(4):480-4  PubMed ID: 19371721   DOI: 10.1016/j.bbrc.2009.04.039
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399   DOI: 10.1271/bbb.80324
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
8757  Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.  Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.  Biol. Pharm. Bull.  2008  31:949-54  PubMed ID: 18451525   DOI: 10.1248/bpb.31.949
10207  Ayako Saruwatari, Shigeaki Okamura, Yoko Nakajima, Yuji Narukawa, Tadahiro Takeda, Hiroomi Tamura  Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells  J Med Food  2008  11(4):623-8  PubMed ID: 19053852   DOI: 10.1089/jmf.2007.0050
12774  Saruwatari A, Isshiki M, Tamura H.  Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells  iol Pharm Bull   2008  31(11):2131-6  PubMed ID: 18981586   DOI: 10.1248/bpb.31.2131
12775  Seki T, Harada S, Hosoya O, Morimoto K, Juni K.  Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes  Biol Pharm Bull   2008  31(1):163-6  PubMed ID: 18175963   DOI: 10.1248/bpb.31.163
12776  Kimura O, Tsukagoshi K, Endo T.  Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter  Toxicol Appl Pharmacol  2008  227(3):325-30  PubMed ID: 18096194   DOI: 10.1016/j.taap.2007.10.028
12777  Kimura H, Yamamoto T, Sakai H, Sakai Y, Fujii T.  An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models  Lab Chip  2008  8(5):741-6  PubMed ID: 18432344   DOI: 10.1039/b717091b
12778  Han Y, Chin Tan TM, Lim LY.  In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression  Toxicol Appl Pharmacol  2008  230(3):283-9  PubMed ID: 18417181   DOI: 10.1016/j.taap.2008.02.026
12779  Fukumori S, Murata T, Takaai M, Tahara K, Taguchi M, Hashimoto Y.  The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells  Drug Metab Pharmacokinet  2008  23(5):373-8  PubMed ID: 18974615   DOI: 10.2133/dmpk.23.373
12780  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.  Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia  J Lipid Res  2008  49(4):763-72.  PubMed ID: 18180267   DOI: 10.1194/jlr.M700293-JLR200
12781  Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y.  The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption  Cell Microbiol  2008  10(2):355-64  PubMed ID: 17868282   DOI: 10.1111/j.1462-5822.2007.01048.x
12785  Takaai M, Morishita H, Ishida K, Taguchi M, Hashimoto Y.  Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells  Eur J Pharmacol  2008  601(1-3):61-5  PubMed ID: 19013148   DOI: 10.1016/j.ejphar.2008.10.047
12786  Kadowaki M, Sugihara N, Tagashira T, Terao K, Furuno K.  Presence or absence of a gallate moiety on catechins affects their cellular transport  J Pharm Pharmacol  2008  60(9):1189-95  PubMed ID: 18718123   DOI: 10.1211/jpp.60.9.0011
12788  Shah AK, Kinoshita M, Kurihara H, Ohnishi M, Takahashi K.  Glycosylceramides obtain from the starfish Asterias amurensis Lütken  J Oleo Sci  2008  57(9):477-84  PubMed ID: 18685230   DOI: 10.5650/jos.57.477
12791  Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.  Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity  Biol Pharm Bull  2008  31(10):1933-7  PubMed ID: 18827358   DOI: 10.1248/bpb.31.1933
12796  Chono S, Takeda E, Seki T, Morimoto K.  Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin  Int J Pharm  2008  347(1-2):71-8  PubMed ID: 17689212   DOI: 10.1016/j.ijpharm.2007.06.037
8807  Katsube T, Tsuji H, Onoda M.  Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.  Biochim. Biophys. Acta  2007  1773:794-803  PubMed ID: 17451824   DOI: 10.1016/j.bbamcr.2007.03.002
8846  Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.  Br. J. Pharmacol.  2007  150:209-19  PubMed ID: 17160010   DOI: 10.1038/sj.bjp.0706972
3580  Ito T, Maki N, Hazeki O, Sasaki K, Nekooki M.  Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines.  Cell Biol Int  2007  31(12):1518-24  PubMed ID: 17719804   DOI: 10.1016/j.cellbi.2007.06.017
3692  Arimochi J, Ohashi-Kobayashi A, Maeda M.  Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.  Biol Pharm Bull  2007  30(4):648-54  PubMed ID: 17409496   DOI: 10.1248/bpb.30.648
3599  Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R.  Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.  Biosci Biotechnol Biochem  2007  71(8):1886-95  PubMed ID: 17690481   DOI: 10.1271/bbb.70109
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453   DOI: 10.1111/j.1365-2672.2006.03260.x
9062  Hitoshi HORIE, Yuichi FUJII, Kouji KATABAMI, Masanori IWAMA, Akira YAMADA  Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype  Journal of Traditional Medicines  2007  24: 156-163    DOI: 10.11339/jtm.24.156
11676  Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, Tomohiro Hosoi  Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid  Biosci Biotechnol Biochem  2007  71(10):2428-34  PubMed ID: 17928716   DOI: 10.1271/bbb.70172
12815  Satoko GUNJI, Joko SANTOSO, Yumiko YOSHIE-STARK, Takeshi SUZUKI  Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide  Food Science and Technology Research  2007  13:275-279    DOI: 10.3136/fstr.13.27
12799  Oda M, Fujimoto K, Kobayashi M, Saitoh H.  Bacampicillin uptake is shared with thiamine in Caco-2 cells  Biol Pharm Bull   2007  30(7):1344-9  PubMed ID: 17603179   DOI: 10.1248/bpb.30.1344
12800  Sugihara N, Toyama K, Okamoto T, Kadowaki M, Terao K, Furuno K.  Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach  Toxicol In Vitro  2007  21(5):827-34  PubMed ID: 17408918   DOI: 10.1016/j.tiv.2007.02.005
12801  Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y.  Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers  Biol Pharm Bull . 2007 Nov;30(11):2167-72  2007  30(11):2167-72  PubMed ID: 17978494   DOI: 10.1248/bpb.30.2167
12802  Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M.  TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation  World J Gastroenterol  2007  13(19):2717-21  PubMed ID: 17569141   DOI: 10.3748/wjg.v13.i19.2717
12804  Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y.  Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells  Biol Pharm Bull  2007  30(10):1930-3  PubMed ID: 17917264   DOI: 10.1248/bpb.30.1930
12805  Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.  Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro  Am J Physiol Gastrointest Liver Physiol  2007  292(3):G923-9  PubMed ID: 17170030   DOI: 10.1152/ajpgi.00145.2006
12807  Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E.  Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells  J Biol Chem  2007  282(10):7742-52  PubMed ID: 17204466   DOI: 10.1074/jbc.M611382200
12810  Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki  Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats  Asian-Australasian Journal of Animal Sciences  2007  20(7): 1120-1126    DOI: 10.5713/ajas.2007.1120
12811  Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T.  Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport  J Pharm Pharmacol  2007  59(10):1383-7  PubMed ID: 17910813   DOI: 10.1211/jpp.59.10.0008
3432  Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro  In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.  Drug Metab Dispos  2006  34:369-74  PubMed ID: 16326817   DOI: 10.1124/dmd.105.006213
3404  Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao  Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.  J Pharm Sci  2006  95:552-60  PubMed ID: 16419049   DOI: 10.1002/jps.20563
8890  Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.  Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.  Biol. Pharm. Bull.  2006  29:535-8  PubMed ID: 16508161   DOI: 10.1248/bpb.29.535
12816  Han Y, Tan TM, Lim LY.  Effects of capsaicin on P-gp function and expression in Caco-2 cells  Biochem Pharmacol  2006  71(12):1727-34  PubMed ID: 16674925   DOI: 10.1016/j.bcp.2006.03.024
12817  Watanabe K, Jinriki T, Sato J.  Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2  Biol Pharm Bull  2006  29(1):90-5  PubMed ID: 16394517   DOI: 10.1248/bpb.29.90
12818  Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T.  Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells  Biosci Biotechnol Biochem  2006  70(12):2906-12  PubMed ID: 17151482   DOI: 10.1271/bbb.60318
12819  Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K.  Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers  J Pharm Sci  2006  95(6):1393-401  PubMed ID: 16625653   DOI: 10.1002/jps.20616
12820  M Gueimonde et al  Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli  Food Research International  2006  39:467-471    DOI: 10.1016/j.foodres.2005.10.003
12821  Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.  Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer  Toxicology  2006  223(1-2):156-65  PubMed ID: 16647797   DOI: 10.1016/j.tox.2006.03.011
12822  Ishida K, Takaai M, Hashimoto Y.  Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells  Biol Pharm Bull  2006  29(3):522-6  PubMed ID: 16508158   DOI: 10.1248/bpb.29.522
12823  Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells  Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells  Food Science and Technology Research  2006  12:290-294    DOI: 10.3136/fstr.12.290
12824  Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.  Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines  J Gastroenterol  2006  2006 Feb;41(2):140-50  PubMed ID: 16568373   DOI: 10.1007/s00535-005-1733-6
12825  Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.  Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF  Hepatol Res  2006  35(3):152-62  PubMed ID: 16707273   DOI: 10.1016/j.hepres.2006.03.011
12826  Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.  Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli  Protein Expr Purif   2006  47(1):144-51  PubMed ID: 16307894   DOI: 10.1016/j.pep.2005.10.011
12827  Makoto KIMURA, Kuninaga DANNO, Hisako YASUI  Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk  Bioscience and Microflora  2006  25:147-155    DOI: 10.12938/bifidus.25.147
12828  Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.  Determination of p-glycoprotein ATPase activity using luciferase  Biol Pharm Bull   2006  29(3):560-4  PubMed ID: 16508168   DOI: 10.1248/bpb.29.560
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294   DOI: 10.1093/jb/mvi177
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879   DOI: 10.1093/jb/mvi003
3026  Aiba T, Susa M, Fukumori S, Hashimoto Y  The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180  Drug Metab Pharmacokinet  2005  20:268-274  PubMed ID: 16141606   DOI: 10.2133/dmpk.20.268
3025  Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya  Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.  Biol Pharm Bull  2005  28:114-9  PubMed ID: 15635174   DOI: 10.1248/bpb.28.114
3072  Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru  Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.  Biosci Biotechnol Biochem  2005  69:202-5  PubMed ID: 15665486   DOI: 10.1271/bbb.69.202
3300  Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki  Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.  Biol Pharm Bull  2005  28:527-30  PubMed ID: 15744083   DOI: 10.1248/bpb.28.527
3155  Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu  Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.  Int J Vitam Nutr Res  2005  75:39-46  PubMed ID: 15830920   DOI: 10.1024/0300-9831.75.1.39
3164  Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923   DOI: 10.1021/bi047606a
3270  Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.  Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.  Hepatol. Res.  2005  33:198-205  PubMed ID: 16198622   DOI: 10.1016/j.hepres.2005.08.005
9134  Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.  CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS  Chiang Mai Med Bull  2005  44:21-28   
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
12832  Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI  Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2  Food Science and Technology Research  2005  11:202-206    DOI: 10.3136/fstr.11.202
12833  Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.  The effects of coffee on conjugation reactions in human colon carcinoma cells  Biol Pharm Bull   2005  28(2):271-4  PubMed ID: 15684482   DOI: 10.1248/bpb.28.271
12835  Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.  Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene  Biochim Biophys Acta  2005  1732(1-3):43-52  PubMed ID: 16380173   DOI: 10.1016/j.bbaexp.2005.11.003
2720  Saegusa S, Totsuka M, Kaminogawa S, Hosoi T  Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.  FEMS Immunol Med Microbiol  2004  41:227-35  PubMed ID: 15196572   DOI: 10.1016/j.femsim.2004.03.006
2736  Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi  Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.  Eur J Pharm Sci  2004  21:87-95  PubMed ID: 14706815   DOI: 10.1016/j.ejps.2003.10.002
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424   DOI: 10.1074/jbc.M401881200
2735  Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi  Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.  Biol Pharm Bull  2004  27:559-63  PubMed ID: 15056866   DOI: 10.1248/bpb.27.559
3199  Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji  Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.  Am J Physiol Cell Physiol  2004  287:C1404-11  PubMed ID: 15229109   DOI: 10.1152/ajpcell.00471.2003
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795
3094  Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu  Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res  2004  64:6410-5  PubMed ID: 15374948   DOI: 10.1158/0008-5472.CAN-04-1543
2708  Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153  
3066  Aida K. et al.  Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.  J Oleo Sci.  2004  53:503-510    DOI: 10.5650/jos.53.503
4723  Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.  4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.  Oncol Res  2004  14(9):407-14  PubMed ID: 15490972   DOI: 10.3727/0965040041791464
12839  Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.  Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells  Biosci Biotechnol Biochem  2004  68(12):2541-6  PubMed ID: 15618625   DOI: 10.1271/bbb.68.2541
12840  Shigeaki Okamura, Hiro-omi Tamura  Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2  Journal of Health Science  2004  50:189-192    DOI: 10.1248/jhs.50.189
12842  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity  Altern Lab Anim  2004  32 Suppl 1A:99-103  PubMed ID: 23577440   DOI: 10.1177/026119290403201s15
12843  Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.  Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids  Cell Transplant  2004  13(4):463-73  PubMed ID: 15468688   DOI: 10.3727/000000004783983882
12844  Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.  The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics  Biochem Pharmacol  2004  67(5):989-1000  PubMed ID: 15104253   DOI: 10.1016/j.bcp.2003.11.002
2645  Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi  Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).  Int J Food Microbiol  2003  82:255-64  PubMed ID: 12593928   DOI: 10.1016/s0168-1605(02)00311-2
3042  Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo  An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.  Biochim Biophys Acta  2003  1612:186-94  PubMed ID: 12787937   DOI: 10.1016/s0005-2736(03)00130-5
18851  Sugawara T, Kinoshita M, Ohnishi M, Nagata J, Saito M.  Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cells  J Nutr  2003  133(9):2777-82  PubMed ID: 12949364   DOI: 10.1093/jn/133.9.2777
3791  Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.  Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.  Pharm Res  2003  20(2):324-7  PubMed ID: 12636175   DOI: 10.1023/a:1022251910820
3792  Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.  Growth promoting effect of thioredoxin on intestinal epithelial cells.  Dig Dis Sci  2003  48(2):379-85  PubMed ID: 12643619   DOI: 10.1023/a:1021952132241
3794  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.  J Artif Organs  2003  6(4):273-81  PubMed ID: 14691670   DOI: 10.1007/s10047-003-0238-4
3796  Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.  Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.  Int J Cancer  2003  107(1):53-9  PubMed ID: 12925956   DOI: 10.1002/ijc.11348
2734  Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:885-90  PubMed ID: 12132663   DOI: 10.1248/bpb.25.885
2629  Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji  Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.  Biochem Biophys Res Commun  2002  296:625-30  PubMed ID: 12176027   DOI: 10.1016/s0006-291x(02)00853-7
2633  Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:1345-50  PubMed ID: 12392092   DOI: 10.1248/bpb.25.1345
3750  Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.  Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.  Microbiol Immunol  2002  46(4):293-7  PubMed ID: 12061632   DOI: 10.1111/j.1348-0421.2002.tb02698.x
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3783  Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.  Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.  J Gastroenterol  2002  37(11):896-904  PubMed ID: 12483244   DOI: 10.1007/s005350200151
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2553  Isozaki T, Tamura H  Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2001  24:1076-8  PubMed ID: 11558573   DOI: 10.1248/bpb.24.1076
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