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Cell No. : Cell Name
RCB0988 : CACO-2  update : 2021/10/12
CommentHuman colon carcinoma. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA86010202 prior to order. Application consideration
Comment from the depositor
Terms and conditionsNaviCyte Scientific holds the exclusive commercial distribution rights to the CACO-2 cell line deposited by the Memorial Sloan-Kettering Cancer Center. Note: All uses of Catalogue Numbers RCB0988, other than for research by a non-commercial or academic entity, require a license and use authorization from NaviCyte Scientific under its exclusive arrangement with Memorial Sloan-Kettering Cancer Center. For information on the licensing terms, please contact NaviCyte Scientific via or (+1) 973-868-6100
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor ECACC
Year of deposit 1994
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 72 years
Tissue colon
Disease name adenocarcinoma
Classification cancer
History overseas, ECACC
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0025
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 20% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% trypsin + 0.02% EDTA
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 85-99(50) : /90(3),91(8),92(4),93(5),94(6)/
STR(human) OK
deposit info
lot info
Reference information Reference 1
User's Publication 349

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1170  Fogh J, Wright, W C, Loveless, J D  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.  J Natl Cancer Inst  1977  58:209-14  PubMed ID: 833871

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User's Publication
12864  Akter M, Atique Ullah AKM, Banik S, Sikder MT, Hosokawa T, Saito T, Kurasaki M.  Green Synthesized Silver Nanoparticles-Mediated Cytotoxic Effect in Colorectal Cancer Cells: NF-κB Signal Induced Apoptosis Through Autophagy  Biol Trace Elem Res  2021  199(9):3272-3286  PubMed ID: 33236292
20031  Yasuda G, Kobayashi M, Kubota A, Narumi K, Furugen A, Saito Y, Satoh T, Suzuki N, Iseki K.  Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin.  Biol Pharm Bull  2021  44(2):275-278  PubMed ID: 33518681
13512  Nozawa T, Iibushi J, Toh H, Minowa-Nozawa A, Murase K, Aikawa C, Nakagawa I.  Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase  mBio  2021  12(1):e01974-20  PubMed ID: 33563838
13556  Zhu Q, Komori H, Imamura R, Tamai I.  A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT  J Pharm Sci  2021  110(3):1392-1400  PubMed ID: 33278408
20064  Morii Y, Tsubaki M, Takeda T, Otubo R, Seki S, Yamatomo Y, Imano M, Satou T, Shimomura K, Nishida S.  Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.  Eur J Pharmacol  2021  898:173957  PubMed ID: 33662352
20066  Mikami D, Sakai S, Nishimukai M, Yuyama K, Mukai K, Igarashi Y.  Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.  Lipids Health Dis  2021  20(1):24  PubMed ID: 33648494
20080  Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M, Saito T.  Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.  Int J Environ Res Public Health  2021  18(4)  PubMed ID: 33671655
20149  Igarashi F, Nakagawa T, Shinohara Y, Tachibana T.  Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.  Pharm Res  2021  Pharm Res  PubMed ID: 34009624
14514  Sato Y, Yamaguchi K, Ogawa M, Takekuma Y, Sugawara M.  An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement  PLoS One  2021  16(6):e0253066  PubMed ID: 34115818
14782  Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A.  MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2  Sci Rep  2021  11(1):5376  PubMed ID: 33686154
14784  Yasuo Ariumi  Host cellular RNA helicases regulate SARS-CoV-2 infection  bioRxiv  2021  June 30, 2021. 
14786  Sasaki M, Uemura K, Sato A, Toba S, Sanaki T, Maenaka K, Hall WW, Orba Y, Sawa H.  SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells  PLoS Pathog  2021  17(1):e1009233  PubMed ID: 33476327
20226  Chowdhury MMI, Tomii A, Ishii K, Tahara M, Hitsuda Y, Koto Y, Kurata K, Yuasa K, Nishimura K, Shimizu H.  TLR4 may be a novel indole-3-acetic acid receptor that is implicated in the regulation of CYP1A1 and TNFα expression depending on the culture stage of Caco-2 cells.  Biosci Biotechnol Biochem  2021    PubMed ID: 34245564
15106  Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N.  Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted fr  Food Chem  2021  360:129822  PubMed ID: 33984564
15149  Gen Toshima, Takanobu Kiuchi, Yuka Iwama, Haruna Ohrui, Fumiko Kimura, Shiho Nakagawa, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata, Junichiro Takahashi  Anti-dyslipidemic effects of water extract from the leaves of Petasites japonicus subsp. giganteus (Akitabuki)  Journal of Biological Macromolecules  2021  21:33-44 
20293  Arai M, Komori H, Fujita D, Tamai I.  Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.  Pharm Res  2021  38(3):523-530  PubMed ID: 33723795
20300  Kitazawa M, Miyagawa Y, Koyama M, Nakamura S, Hondo N, Miyazaki S, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Kuroiwa M, Tanaka H, Komatsu D, Takeoka M, Soejima Y.  Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG-510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL.  Mol Clin Oncol  2021  15(1):148  PubMed ID: 34094546
15288  Akihiro Nishiguchi, Tetsushi Taguchi  Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis  Advanced Functional Materials  2021  2100548 
15412  Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.  Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer  Cancer Sci  2021  112(8):3173-3189  PubMed ID: 34008277
15564  Negoro R, Yamada N, Watanabe K, Kono Y, Fujita T.  Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system  Arch Toxicol  2021  Oct 16  PubMed ID: 34654938
13449  Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi  Structure-dependent absorption of sphingolipid long-chain bases from the digestive tract into lymph  BMC  2020/1/1   
11781  Tachibana K, Kondoh M.  A Method to Prepare Claudin-Modulating Recombinant Proteins.  Methods Mol. Biol  2020  2109:251-260  PubMed ID: 31471875
11784  Date K, Yamazaki T, Toyoda Y, Hoshi K, Ogawa H.  α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation.  J. Cell. Biochem  2020  121(2):1238-1249  PubMed ID: 31478242
11981  Kawahara T, Fujii K, Nakajima K, Fujii R, Inagaki S, Hara K, Yasui H.  Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells.  Planta Med.  2020    PubMed ID: 31896136
12099  Meparambu Prabhakaran D, Ramamurthy T, Thomas S.  Genetic and virulence characterisation of Vibrio parahaemolyticus isolated from Indian coast.  BMC Microbiol.  2020    PubMed ID: 32293257
12276  Michihito Sasaki, Kentaro Uemura, Akihiko Sato, Shinsuke Toba, Takao Sanaki, Katsumi Maenaka, William W. Hall, Yasuko Orba, Hirofumi Sawa  SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells  bioRxiv  2020  August 28 
13047  Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N.  Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential.  Bioorg Med Chem  2020    PubMed ID: 32616184
13091  Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.  Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.  Carbohydr Polym  2020    PubMed ID: 32829826
13136  Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S.  10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.  Biol Pharm Bull  2020    PubMed ID: 32741940
13162  Jutanom M, Higaki C, Yamashita S, Nakagawa K, Matsumoto S, Kinoshita M.  Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.  J Oleo Sci  2020    PubMed ID: 32788522
13201  Koyama M, Kitazawa M, Nakamura S, Matsumura T, Miyazaki S, Miyagawa Y, Muranaka F, Tokumaru S, Okumura M, Yamamoto Y, Ehara T, Hondo N, Takahata S, Takeoka M, Miyagawa SI, Soejima Y.  Low‑dose trametinib and Bcl‑xL antagonist have a specific antitumor effect in KRAS‑mutated colorectal cancer cells.  Int J Oncol  2020    PubMed ID: 32901840
13211  Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.  Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells.  Biochem Biophys Rep  2020    PubMed ID: 32964147
13234  Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32977947
13252  Yamashiro T, Yasujima T, Said HM, Yuasa H.  pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates.  J Biol Chem  2020    PubMed ID: 33008889
13289  Abe H, Koyama K, Koseki S.  Modeling Invasion of Campylobacter jejuni into Human Small Intestinal Epithelial-Like Cells by Bayesian Inference.  Appl Environ Microbiol  2020    PubMed ID: 33067190
13316  Nagata Y, Yamamoto T, Kadowaki M.  Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.  J Nutr Sci Vitaminol (Tokyo)  2020    PubMed ID: 33132350
13517  Takizawa Y, Tobe Y, Sakamoto N, Sakamoto J, Hayashi M.  Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route  J Membr Biol  2020  253(3):221-228  PubMed ID: 32328687
13550  Kawaguchi M, Yamamoto K, Kataoka H, Izumi A, Yamashita F, Kiwaki T, Nishida T, Camerer E, Fukushima T.  Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc Min/+ mice  Cancer Sci  2020  111(4):1193-1202  PubMed ID: 31997435
13574  Yamashita S, Seino T, Inobe M, Jutanom M, Matsumoto S, Kinoshita M.  Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro  J Oleo Sci  2020  69(7):751-757  PubMed ID: 32612025
13620  Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.  Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats  Front Pharmacol  2020  11:1277  PubMed ID: 32922296
13623  BaoruiLi et al  Theaflavins inhibit glucose transport across Caco-2 cells through the downregulation of the Ca2+/AMP-activated protein kinase-mediated glucose transporter SGLT1  Journal of Functional Foods  2020  75:104273 
13646  Sato Y, Yokoyama S, Yamaki Y, Nishimura Y, Miyashita M, Maruyama S, Takekuma Y, Sugawara M.  Enhancement of intestinal absorption of coenzyme Q10 using emulsions containing oleyl polyethylene acetic acids  Eur J Pharm Sci   2020  142:10514  PubMed ID: 31730802
13840  Nakajima T, Sasaki K, Yamamori A, Sakurai K, Miyata K, Watanabe T, Matsunaga YT.  A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays  Biomater Sci  2020  8(20):5615-5627  PubMed ID: 32945306
20270  Nguma E, Yamashita S, Kumagai K, Otoki Y, Yamamoto A, Eitsuka T, Nakagawa K, Miyazawa T, Kinoshita M.  Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress.  ACS Omega  2020  6(4):3140-3148  PubMed ID: 33553930
15260  Mu Y, Li J, Kang JH, Eto H, Zai K, Kishimura A, Hyodo F, Mori T, Katayama Y.  A Lipid-Based Nanocarrier Containing Active Vitamin D 3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation  Biol Pharm Bull  2020  43(9):1413-1420  PubMed ID: 32879216
11283  Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N.  NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.  FASEB J.  2019    PubMed ID: 30399323
11320  Hayashi I, Kanda S, Lamaningao P, Mishima N, Nishiyama T.  Shared expression of mucin12 in Ascaris lumbricoides and the human small intestine.  Mol. Biochem. Parasitol.  2019    PubMed ID: 30481538
11386  Uchiyama H, Wada Y, Hatanaka Y, Hirata Y, Taniguchi M, Kadota K, Tozuka Y.  Solubility and Permeability Improvement of Quercetin by an Interaction Between α-Glucosyl Stevia Nanoaggregates and Hydrophilic Polymer.  J Pharm Sci  2019    PubMed ID: 30653971
11426  Kurata K, Kawahara H, Nishimura K, Jisaka M, Yokota K, Shimizu H.  Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30739789
11487  Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N.  A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing.  Sci Rep  2019    PubMed ID: 30894579
11641  Morito K, Shimizu R, Kitamura N, Park SB, Kishino S, Ogawa J, Fukuta T, Kogure K, Tanaka T.  Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 31351225
11702  Hiroaki Shimada, Chiaki Kuma, Taichi Iseri, Shin-ichi Matsumura, Atsushi Kawase, Masayoshi Matsuura, Masahiro Iwaki  Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose  Natural Product Communications  2019   
11825  Manabe Y, Ichihara M, Fukuda K, Tomonaga N, Li ZS, Yamanashi Y, Suzuki H, Takada T, Matsuo M, Sugawara T.  Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin.  Lipids  2019    PubMed ID: 31574565
11871  Numata T, Sato-Numata K, Okada Y.  Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.  Sci Rep  2019    PubMed ID: 31664151
6882  Shinji S, Sasaki N, Yamada T, Koizumi M, Ohta R, Matsuda A, Yokoyama Y, Takahashi G, Hotta M, Hara K, Takeda K, Ueda K, Kuriyama S, Ishiwata T, Ueda Y, Murakami T, Kanazawa Y, Yoshida H.  Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.  Cancer Sci  2019  110(12):3708-3717  PubMed ID: 31648389
6921  Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.  Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.  Nutr Res  2019  72:92-104  PubMed ID: 31767206
6940  Nagayasu M, Ozeki K, Sakurai Y, Tsutsui H, Onoue S.  Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay Data.  Pharm Res  2019  37(1):13  PubMed ID: 31873817
6942  Mahmoud Abdel-Hamid et al  The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage  International Dairy Journal   2019  91:1-8 
6966  Matsuzaki T, Nakamura M, Nogita T, Sato A.  Cellular Uptake and Release of Intact Lactoferrin and Its Derivatives in an Intestinal Enterocyte Model of Caco-2 Cells.  Biol Pharm Bull  2019  42(6):989-995  PubMed ID: 31155596
9418  Masanori Horie, Hiroaki Sato, Atsumi Tada, Sayaka Nakamura, Sakiko Sugino, Yosuke Tabei, Miyuki Katoh, Takahito Toyotome  Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha  iosci Microbiota Food Health  2019  38(1):11-22  PubMed ID: 30705798
9414  Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2  CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin  Mol Cell Biol  2019  39(16):e00073-19  PubMed ID: 31160493
10420  Sanae Yoshimoto, Keiko Okada, Osamu Hayashi  Immuno-regulatory and anti-inflammatory actions of phycocyanin on Caco-2/U937 cells co-culture as a model of the intestinal barrier  Functional Foods in Health and Disease  2019  9(7):466-483  
10587  Selma Etteieb Jamila Tarhouni Hiroko Isoda  Cellular stress response biomarkers for toxicity potential assessment of treated wastewater complex mixtures  Water and Environment Journal  2019  33:4-13 
10588  Thaíse Maria Nogueira Mendes, Yukihisa Murayama, Natsumi Yamaguchi, Geni Rodrigues Sampaio, Luciana Cristina Brigatto Fontes, Elizabeth Aparecida Ferraz da Silva Torres, Hirotoshi Tamura, Lina Yonekura  Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients  Journal of Functional Foods  2019  55:352-361 
11913  Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.  Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.  Cancers (Basel)  2019    PubMed ID: 31769426
12013  Matsumoto A, Watanabe C, Murakami M.  Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.  Drug Discov Ther  2019    PubMed ID: 31956233
12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389
12517  Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.  Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)  Nat Prod Res  2019  33(2):189-195  PubMed ID: 29457741
10543  Seike S, Takehara M, Takagishi T, Miyamoto K, Kobayashi K, Nagahama M.  Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.  Biochim. Biophys. Acta  2018  1860:428-433  PubMed ID: 28988777
10556  Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.  Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.  Toxicol In Vitro  2018  46:284-293  PubMed ID: 29054700
10580  Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.  Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.  Glycobiology  2018  28:21-31  PubMed ID: 29069492
10656  Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M.  Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.  Arch. Biochem. Biophys.  2018  638:58-65  PubMed ID: 29242061
10665  Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.  The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.  Oncogene  2018  37:1205-1219  PubMed ID: 29242607
10681  Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J.  Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.  Exp. Anim.  2018  67:201-218  PubMed ID: 29276215
10794  Numata T, Sato-Numata K, Okada Y, Inoue R.  Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl-/water secretion that involves cAMP-dependent activation of CFTR.  J Nat Med  2018  72:694-705  PubMed ID: 29569221
11102  Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K.  A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.  Sci Rep  2018  8(1):9008  PubMed ID: 29899364
11130  Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W.  Probiotics in human gut microbiota can degrade host glycosaminoglycans.  Sci Rep  2018  8(1):10674  PubMed ID: 30006634
11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033
4174  Sakuta Y, Takehara I, Tsunoda KI, Sato K.  Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance.  Anal Sci  2018    PubMed ID: 29806615
4472  Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.  Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.  Inflamm. Res.  2018  67(11-12):975-984  PubMed ID: 30317465
4473  Yano A, Takahashi K, Mori Y, Watanabe S, Hanamura Y, Sugiyama T, Inoue N.  Peyer's Patches as a Portal for DNA Delivery by Lactococcus lactis in Vivo.  Biol. Pharm. Bull.  2018  41(2):190-197  PubMed ID: 29386479
9492  Kazuhide Nakayama # 1, Magdalena M Szewczyk # 2, Carlo Dela Sena # 2, Hong Wu 2, Aiping Dong 2, Hong Zeng 2, Fengling Li 2, Renato Ferreira de Freitas 2, Mohammad S Eram 2, Matthieu Schapira 2 3, Yuji Baba 1, Mihoko Kunitomo 1, Douglas R Cary 1, Michiko Tawada 4, Akihiro Ohashi 1, Yasuhiro Imaeda 1, Kumar Singh Saikatendu 5, Charles E Grimshaw 6, Masoud Vedadi 2 3, Cheryl H Arrowsmith 2 7, Dalia Barsyte-Lovejoy, Atsushi Kiba, Daisuke Tomita, Peter J Brown  TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma  Oncotarget  2018  9(26):18480-18493  PubMed ID: 29719619
9909  Takayama Y, Aoki R, Uchida R, Tajima A, Aoki-Yoshida A.  Role of CXC chemokine receptor type 4 as a lactoferrin receptor.  Biochem. Cell Biol.  2017  95:57-63  PubMed ID: 28075616
10056  Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E.  miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.  BMC Cancer  2017  17:33  PubMed ID: 28061765
10091  Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y.  Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.  Biochem. Biophys. Res. Commun.  2017  484:543-549  PubMed ID: 28130106
10167  Takahashi K, Suzuki N, Ogra Y.  Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.  Int J Mol Sci  2017  18:  PubMed ID: 28245633
10214  Nakahara T, Nishitani Y, Nishiumi S, Yoshida M, Azuma T.  Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers.  Eur. J. Pharmacol.  2017  804:46-51  PubMed ID: 28327343
10227  Sugihara N, Kuroda N, Watanabe F, Choshi T, Kamishikiryo J, Seo M.  Effects of Catechins and Their Related Compounds on Cellular Accumulation and Efflux Transport of Mitoxantrone in Caco-2 Cell Monolayers.  J. Food Sci.  2017  82:1224-1230  PubMed ID: 28346686
10247  Fujii K, Abe K, Kadooka K, Matsumoto T, Katakura Y.  Carnosine activates the CREB pathway in Caco-2 cells.  Cytotechnology  2017  69:523-527  PubMed ID: 28374107
10319  Nakayama T, Funakoshi-Tago M, Tamura H.  Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.  Oncol Lett  2017  14:1109-1114  PubMed ID: 28693281
10325  Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T.  Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides.  Toxicol. Lett.  2017  277:18-23  PubMed ID: 28552774
10474  Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.  Biochem. Pharmacol.  2017  145:192-201  PubMed ID: 28843775
10552  Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293
10635  Yamashita S, Seino T, Aida K, Kinoshita M.  Effects of Plant Sphingolipids on Inflammatory Stress in Differentiated Caco-2 Cells.  J Oleo Sci  2017  66:1337-1342  PubMed ID: 29199207
10976    Effect of luteolin on the expression of intestinal cholesterol transporters  Journal of Functional Foods  2017  36:274-279 
10979    1-alpha, 25-dihydroxyvitamin D3 up-regulates the expression of two types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis  Nutrition Research  2017  46, 59-67  PubMed ID: 28931466
10996    Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells  Journal of Functional Foods  2017  39, 91-95 
10999    Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity  Food Science and Technology Research  2017  23, 725-732 
4194  Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.  A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.  Lab Chip  2017    PubMed ID: 29184959
10008  Misato Kashiba, Masayuki Terashima, Tomofumi Sagawa, Shinichi Yoshimura, Yorihiro Yamamoto  Prosaposin Knockdown in Caco-2 Cells Decreases Cellular Levels of Coenzyme Q10 and ATP, and Results in the Loss of Tight Junction Barriers  J Clin Biochem Nutr  2017  60(2):81-85  PubMed ID: 28366985
10019  Tomoki Kabeya, Wakana Matsumura, Takahiro Iwao, Masakiyo Hosokawa, Tamihide Matsunaga  Functional Analysis of Carboxylesterase in Human Induced Pluripotent Stem Cell-Derived Enterocytes  Biochem Biophys Res Commun  2017  486(1):143-148  PubMed ID: 28285137
10025  Yang Liu, Yoshihiro Ojima, Masanobu Horie, Eiji Nagamori & Hideaki Fujita  Design and fabrication of devices for investigating cell-sheet stretch  BioChip Journal  2017  11:173–179 
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625
10035  Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari   Uric Acid Ameliorates Indomethacin-Induced Enteropathy in Mice Through Its Antioxidant Activity  J Gastroenterol Hepatol  2017  32(11):1839-1845  PubMed ID: 28295549
9931  Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito  Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications  Front Physiol  2017  8:997  PubMed ID: 29259558
14774  Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism  Kidney Int  2017  91(3):658-670  PubMed ID: 27988213
7107  Yamazoe H, Ichikawa T, Hagihara Y, Iwasaki Y.  Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.  Acta Biomater  2016  31:231-240  PubMed ID: 26685756
9508  Kaku Y, Tsuchiya A, Shimizu T, Tanaka A, Nishizaki T.  HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.  Anticancer Res.  2016  36:39-48  PubMed ID: 26722026
9525  Ikai A, Watanabe M, Sowa Y, Kishimoto M, Yanagisawa A, Fujiwara H, Otsuji E, Sakai T.  Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.  Int. J. Oncol.  2016  48:1297-304  PubMed ID: 26783196
9544  Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.  Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.  Sci Rep  2016  7:20069  PubMed ID: 26822058
9580  Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K.  Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.  J Nat Med  2016  70:661-6  PubMed ID: 26899240
9590  Jdir H, Khemakham B, Najjaa H, Chakroun M, Jridi M, Ben Arfa A, Ben Ali Y, Zouari N.  Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous: Diplotaxis simplex.  Pharm Biol  2016  54:2111-8  PubMed ID: 26916801
9638  Kaze N, Watanabe Y, Sato H, Murota K, Kotaniguchi M, Yamamoto H, Inui H, Kitamura S.  Estimation of the Intestinal Absorption and Metabolism Behaviors of 2- and 3-Monochloropropanediol Esters.  Lipids  2016  51:913-22  PubMed ID: 27023203
9646  Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T.  Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.  J. Biol. Chem.  2016  291:12586-600  PubMed ID: 27053111
9688  Kimura O, Fujii Y, Haraguchi K, Ohta C, Koga N, Kato Y, Endo T.  Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers.  J. Pharm. Pharmacol.  2016  68:883-9  PubMed ID: 27166429
9699  Kudo M, Katayoshi T, Kobayashi-Nakamura K, Akagawa M, Tsuji-Naito K.  H(+)/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport.  Biochem. Biophys. Res. Commun.  2016  475:335-41  PubMed ID: 27216463
10030  Zhao C, Sakaguchi T, Fujita K, Ito H, Nishida N, Nagatomo A, Tanaka-Azuma Y, Katakura Y.  Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation.  Oxid Med Cell Longev  2016  2016:2927131  PubMed ID: 27840668
10884    Combining Biological and Chemical Screenings to Assess Cytotoxicity of Emerging Contaminants in Discharges into Surface Water  Water, Air, & Soil Pollution  2016  227:341 
5810  Kitagawa N et al  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.  Int J Mol Sci  2016  17(12). pii: E1979  PubMed ID: 27898032
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591
9989  Takako Taniguchi, Wataru Yamazaki, Yuji Saeki, Ichiro Takajo, Akihiko Okayama, Tetsuya Hayashi, Naoaki Misawa  The Pathogenic Potential of Helicobacter Cinaedi Isolated From Non-Human Sources: Adherence, Invasion and Translocation Ability in Polarized Intestinal Epithelial Caco-2 Cells in Vitro  J Vet Med Sci  2016  78(4):627-32  PubMed ID: 26685883
10107  Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone  Menaquinone-4 (Vitamin K 2) Up-Regulates Expression of Human Intestinal Alkaline Phosphatase in Caco-2 Cells  Nutr Res .  2016  36(11):1269-1276  PubMed ID: 27865621
10108  Katsuya Narumi, Masaki Kobayashi, Ayuko Kondo, Ayako Furugen, Takehiro Yamada, Natsuko Takahashi, Ken Iseki  Characterization of Loxoprofen Transport in Caco-2 Cells: The Involvement of a Proton-Dependent Transport System in the Intestinal Transport of Loxoprofen  Biopharm Drug Dispos   2016  7(8):447-455  PubMed ID: 27514365
10110  Yuto Takekawa, Yuki Sato, Yoshiaki Yamaki, Mei Imai, Kazuma Noto, Masato Sumi, Yoh Takekuma, Ken Iseki, Mitsuru Sugawara  An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1  Biol Pharm Bull .   2016  39(3):301-7  PubMed ID: 26934923
10111  Yhiya M.Amen, Qinchang Zhu, Mohamed S.Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu  New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi  Phytochemistry Letters  2016  17:64-70 
12897  Iwazaki A, Takahashi N, Miyake R, Hiroshima Y, Abe M, Yasui A, Imai K.  Effect of dietary fibers on losartan uptake and transport in Caco-2 cells  Biopharm Drug Dispos  2016  37(4):212-9  PubMed ID: 26748460
14091  Gakuro Harada, Pawat Pattarawat, Kenji Ito, Takashi Matsumoto, Takanori Hasegawa, Yoshinori Katakura  Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1  Journal of Functional Foods  2016  23:444-452 
14133  Guo L, Yamashita H, Kou I, Takimoto A, Meguro-Horike M, Horike S, Sakuma T, Miura S, Adachi T, Yamamoto T, Ikegawa S, Hiraki Y, Shukunami C.  Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation  PLoS Genet  2016  12:e1005802  PubMed ID: 26820155
7117  Shimizu T, Ichimura K, Noda M.  The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.  Infect. Immun.  2015  84:537-49  PubMed ID: 26644384
7203  Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T.  The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus.  FEMS Microbiol. Lett.  2015  362:  PubMed ID: 26394644
7295  Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K.  Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.  Biochem. Pharmacol.  2015  97:89-98  PubMed ID: 26119820
7414  Kaku Y, Tsuchiya A, Kanno T, Nishizaki T.  Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.  Pharmacology  2015  95:154-9  PubMed ID: 25833236
7419  Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A.  Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.  Int. J. Mol. Med.  2015  35:1603-9  PubMed ID: 25816245
7436  Hsieh CY, Osaka T, Moriyama E, Date Y, Kikuchi J, Tsuneda S.  Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum.  Physiol Rep  2015  3:  PubMed ID: 25780093
7574  Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA  Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.  Deep Ocean Water Research  2015  15:117-124 
9472  Yasuyuki Kitaura, Kana Inoue, Naoki Kato, Nahomi Matsushita, Yoshiharu Shimomura  Enhanced Oleate Uptake and Lipotoxicity Associated With Laurate  FEBS Open Bio . 2015 May 29;5:485-91  2015  5:485-91  PubMed ID: 26106523
10118  Yuki Yoshioka, Hironosuke Fujibayashi, Kenji Kameda, Daijiro Kan, Shigenobu Tone, Minoru Tamura  Induction of Apoptosis in Caco-2 Cells by Exogenously Added O₂⁻ Produced by a Nanodevice  Exp Cell Res  2015  331(2):408-15  PubMed ID: 25542842
10149  Kazuya Ishida, Asuka Horie, Emi Matsuba, Yuri Watanabe, Miki Fukao, Yukiya Hashimoto    Jpn J Pharm Health Care Sci  2015  41(4): 236―243 
10150  Mai Furumiya, Takahiro Yamashiro, Katsuhisa Inoue, Chihiro Nishijima, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa  Sustained Inhibition of Proton-Coupled Folate Transporter by Myricetin  Drug Metab Pharmacokinet  2015  30(2):154-9.  PubMed ID: 25801697
10151  Yuki Shiga, Yuta Oshima, Yoshinori Kojima, Akinori Sugimoto, Naomi Tamaki, Daisuke Murata, Takashi Takeuchi, Atsushi Sato  Recombinant Human lactoferrin-Fc Fusion With an Improved Plasma Half-Life  Eur J Pharm Sci  2015  67:136-143  PubMed ID: 25433245
10152  Long Binh Vong, John Mo, Bertil Abrahamsson, Yukio Nagasaki  Specific Accumulation of Orally Administered Redox Nanotherapeutics in the Inflamed Colon Reducing Inflammation With Dose-Response Efficacy  J Control Release  2015  210:19-25  PubMed ID: 25998050
9993  Yasushi Hasegawa, Yukiya Kadota, Chihiro Hasegawa, Satoshi Kawaminami  Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption  J Nutr Sci Vitaminol (Tokyo)   2015  61(6):449-54  PubMed ID: 26875485
10154  Selma Etteieba, Atsushi Kawachib, Junkyu Hanb, Jamila Tarhouni and Hiroko Isodab  Bioanalytical tests for assessing cytotoxicity and estrogenicity effects of treated wastewater on mammalian cell lines   Energy Procedia  2015  74:878 – 885  
10156  Takashi Satoh, Masaki Igarashi, Shogo Yamada, Natsuko Takahashi, Kazuhiro Watanabe  Inhibitory Effect of Black Tea and Its Combination With Acarbose on Small Intestinal α-Glucosidase Activity  J Ethnopharmacol  2015  161:147-55  PubMed ID: 25523370
10157  Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano  The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells  J Cell Mol Med  2015  19(7):1569-81  PubMed ID: 25689483
10158  Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida  Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer  Mol Clin Oncol  2015  3(5):1080-1084  PubMed ID: 26623054
10159  Norisuke Shibuya, Ken-ichi Inoue, Genki Tanaka, Kazumi Akimoto, Keiichi Kubota  Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas  Oncology  2015  88(5):309-19  PubMed ID: 25591719
10160  Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa  Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval Through N-Glycan-specific Binding, Endocytosis, and Degradation  J Biol Chem  2015  ;290(28):17439-50  PubMed ID: 26023238
10172  Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-Ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C Gore, Wellington Pham  Toxicity Studies of Coumarin 6-encapsulated Polystyrene Nanospheres Conjugated With Peanut Agglutinin and poly(N-vinylacetamide) as a Colonoscopic Imaging Agent in Rats  Nanomedicine  2015  11(5):1227-36  PubMed ID: 25725490
14459  Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.  MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells  PLoS One  2015  10(5):e0127119  PubMed ID: 25970424
15177  Ozeki K, Kato M, Sakurai Y, Ishigai M, Kudo T, Ito K.  Evaluation of the appropriate time range for estimating the apparent permeability coefficient (P(app)) in a transcellular transport study  Int J Pharm  2015  495(2):963-71  PubMed ID: 26387619
10196  Mari Nekohashi, Mana Ogawa, Takuo Ogihara, Kyoko Nakazawa, Hisanori Kato, Takumi Misaka, Keiko Abe, Shoko Kobayashi  Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick c1-like 1 in caco-2 Cells and Rats  PLoS One   2014  9(5):e97901  PubMed ID: 24859282
10198  Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo  Carrier-mediated Uptake of Nobiletin, a Citrus Polymethoxyflavonoid, in Human Intestinal Caco-2 Cells  Food Chem  2014  154:145-50  PubMed ID: 24518326
10199  Kensuke Tsukagoshi, Osamu Kimura, Tetsuya Endo  Steric Hindrance of 2,6-disubstituted Benzoic Acid Derivatives on the Uptake via Monocarboxylic Acid Transporters From the Apical Membranes of Caco-2 Cells  Pestic Biochem Physiol .  2014  111:38-42  PubMed ID: 24861932
10202  Natsuko Takahashi 1, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki  Immunoprotective Effect of epigallocatechin-3-gallate on Oral Anticancer Drug-Induced α-Defensin Reduction in Caco-2 Cells  Biol Pharm Bull  2014  37(3):490-2  PubMed ID: 24583869
10203  Claudia Gemelli, Bendjedith Momo Dongmo, Fabrizio Ferrarini, Alexis Grande, Lorenzo Corsi  Cytotoxic Effect of Hemin in Colonic Epithelial Cell Line: Involvement of 18 kDa Translocator Protein (TSPO)  Life Sci .   2014  107(1-2):14-20  PubMed ID: 24792517
10204  Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo  Uptake of Aristolochic Acid I Into Caco-2 Cells by Monocarboxylic Acid Transporters  Biol Pharm Bull .   2014  37(9):1475-9  PubMed ID: 25177030
10208  Ayuko Imaoka, Michiko Hattori, Takeshi Akiyoshi, Hisakazu Ohtani  Decrease in Ciprofloxacin Absorption by Polyvalent Metal Cations Is Not Fully Attributable to Chelation or Adsorption  Drug Metab Pharmacokinet  2014  29(5):414-8  PubMed ID: 24806820
10209  Yuuki Kaito, Ryosuke Kataoka, Kento Takechi, Tatsuya Mihara, Minoru Tamura  Nox1 Activation by βPix and the Role of Ser-340 Phosphorylation  FEBS Lett .   2014  588(11):1997-2002  PubMed ID: 24792722
10223  Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, Yuji Sakurai, Osamu Kondoh, Hiroshi Sakamoto  Antitumor Activity of the Selective ALK Inhibitor Alectinib in Models of Intracranial Metastases  Cancer Chemother Pharmacol  2014  74(5):1023-8  PubMed ID: 25205428
10224  Toshio Ishikawa, Satoshi Takahashi, Koji Morita, Hiroko Okinaga, Tamio Teramoto  Induction of AhR-mediated Gene Transcription by Coffee  PLoS One  2014  9(7):e102152  PubMed ID: 25007155
10225  Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro Yamashiro, Erina Inaoka, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa  Noncompetitive Inhibition of Proton-Coupled Folate Transporter by Myricetin  Drug Metab Pharmacokinet  2014  29(4):312-6  PubMed ID: 24492671
10226  Yusuke Terada, Jiro Ogura, Takashi Tsujimoto, Kaori Kuwayama, Takahiro Koizumi, Shunichi Sasaki, Hajime Maruyama, Masaki Kobayashi, Hiroaki Yamaguchi, Ken Iseki  Intestinal P-glycoprotein Expression Is Multimodally Regulated by Intestinal Ischemia-Reperfusion  J Pharm Pharm Sci  2014  17(2):266-76  PubMed ID: 24934555
10229  Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto  Involvement of Intestinal Permeability in the Oral Absorption of Clarithromycin and Telithromycin  Biopharm Drug Dispos  2014  35(6):321-9  PubMed ID: 24801141
10237  Mayumi Chiba, Chikako Yokoyama, Mai Okada, Hisashi Hisatomi  Mitochondrial DNA Reduced by Hypoxic Conditions in Three-Dimensional (3D) Spheroid Cell Cultures  Tumour Biol  2014  35(12):12689-93  PubMed ID: 25217322
10242  T Nakayama, K Ezoe  Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O  Curr Microbiol .  2014  69(5):690-8  PubMed ID: 24974216
10243  Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki  Development of Nitroxide Radicals-Containing Polymer for Scavenging Reactive Oxygen Species From Cigarette Smoke  Sci Technol Adv Mater  2014  15(3):035002  PubMed ID: 27877678
10244  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto  Suppressive Action of Acetate on interleukin-8 Production via Tubulin-α Acetylation  Immunol Cell Biol  2014  92(7):624-30  PubMed ID: 24777307
10254  Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi  Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells  J Clin Biochem Nutr  2014  55(3):162-7  PubMed ID: 25411520
10259  Susumu Hama, Yuki Kimura, Aya Mikami, Kanako Shiota, Mao Toyoda, Atsushi Tamura, Yukio Nagasaki, Kiyoshi Kanamura, Kazuaki Kajimoto, Kentaro Kogure  Electric Stimulus Opens Intercellular Spaces in Skin  J Biol Chem  2014  24;289(4):2450-6  PubMed ID: 24318878
10262  Shin-Ichiro Miyashita, Koichi Niwa, Toshihiro Watanabe, Yoshimasa Sagane  Host-cell Specificity and Transcytosis of Nontoxic Nonhemagglutinin Protein of Botulinum Neurotoxin Serotype D  FEMS Microbiol Lett  2014  2014 Aug;357(2):115-22  PubMed ID: 25041523
6429  Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.  Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.  Biochim Biophys Acta  2013  1832(1):151-9  PubMed ID: 23064287
12694  Isshiki M, Ohta H, Tamura H.  Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells  Biol Pharm Bull  2013  36(2):299-304  PubMed ID: 23370358
12695  Togami K, Tosaki Y, Chono S, Morimoto K, Hayasaka M, Tada H.  Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells  J Pharm Pharmacol  2013  65(1):22-9  PubMed ID: 23215684
12696  Takahashi J, Ogihara K, Naya Y, Kimura F, Itoh M, Iwama Y, Matsumoto Y, Toshima G, Hata K.  An in vitro assay system for antihyperlipidemic agents by evaluating lipoprotein profiles from human intestinal epithelium-like cells  3 Biotech  2013  3(3):213-218  PubMed ID: 28324370
12697  Iraha A, Chinen H, Hokama A, Yonashiro T, Kinjo T, Kishimoto K, Nakamoto M, Hirata T, Kinjo N, Higa F, Tateyama M, Kinjo F, Fujita J.  Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1  World J Gastroenterol  2013  19(33):5500-7  PubMed ID: 24023493
12698  Seki T, Hamada A, Egawa Y, Yamaki T, Uchida M, Natsume H, Kimura S, Ueda H.  Evaluation of the effects of absorption enhancers on Caco-2 cell monolayers by using a pore permeation model involving two different sizes  Biol Pharm Bull  2013  36(11):1862-6  PubMed ID: 24189430
12699  Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.  Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation  J Biol Chem  2013  288(19):13317-24  PubMed ID: 23532847
12700  Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.  INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors  Biochem Biophys Res Commun  2013  432(4):586-92  PubMed ID: 23438439
12701  Huanbutta K, Sriamornsak P, Luangtana-Anan M, Limmatvapirat S, Puttipipatkhachorn S, Lim LY, Terada K, Nunthanid J.  Application of multiple stepwise spinning disk processing for the synthesis of poly(methyl acrylates) coated chitosan-diclofenac sodium nanoparticles for colonic drug delivery  Eur J Pharm Sci  2013  50(3-4):303-11  PubMed ID: 23896171
12702  Kamishikiryo J, Matsumura R, Takamori T, Sugihara N.  Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid  J Pharm Pharmacol  2013  65(7):1037-43  PubMed ID: 23738731
12704  Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K.  Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections  Microb Pathog  2013  65:14-20  PubMed ID: 24036179
12705  Sezaki T, Tomiyama L, Kimura Y, Ueda K, Kioka N.  Dlg5 interacts with the TGF-β receptor and promotes its degradation  FEBS Lett  2013  587(11):1624-9  PubMed ID: 23624079
12706  Tominaga A, Konishi Y, Taguchi T, Fukuoka S, Kawaguchi T, Noda T, Shimizu K.  Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides  Int Immunopharmacol  2013  17(4):1009-19  PubMed ID: 24126111
12693  Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.  Possible involvement of Wnt11 in colorectal cancer progression  Mol Carcinog   2013  52(3):207-17  PubMed ID: 22161723
7625  Ito N, Ohtsubo T, Kusu F, Hakamata H.  An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells.  Anal. Biochem.  2012  421:86-91  PubMed ID: 22119071
6316  Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F.  Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.  Int J Oncol  2012  40(1):217-26  PubMed ID: 21901246
10981  Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto  Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells  J Med Food  2012  15(6):511-9  PubMed ID: 22510151
12711  Kimura O, Tsukagoshi K, Hayasaka M, Endo T.  Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells  Arch Toxicol  2012  86(1):55-61  PubMed ID: 21766207
12712  Yanagihara S, Hirota T, Yamamoto N.  Transcriptional response of Lactobacillus acidophilus L-92 after attachment to epithelial Caco-2 cells  J Biosci Bioeng  2012  114(6):582-5  PubMed ID: 22841868
12713  Matsuo Y, Miyoshi Y, Okada S, Satoh E.  Receptor-like Molecules on Human Intestinal Epithelial Cells Interact with an Adhesion Factor from Lactobacillus reuteri  Biosci Microbiota Food Health  2012  31(4):93-102  PubMed ID: 24936355
12714  Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M.  CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer  Eur J Cancer  2012  48(14):2244-51.  PubMed ID: 22197219
12715  Zhang K, Yamamoto Y, Suzuki T, Yokota K, Ma S, Ni Nengah Dwi Fatmawati, Oguma K.  Clostridium botulinum type E toxins bind to Caco-2 cells by a different mechanism from that of type A toxins  Acta Med Okayama  2012  66(3):253-61  PubMed ID: 22729106
12716  Sato Y, Suzuki R, Kobayashi M, Itagaki S, Hirano T, Noda T, Mizuno S, Sugawara M, Iseki K.  Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein  J Pharm Pharm Sci  2012  15(2):256-64  PubMed ID: 22579005
12722  Pervin M, Paeng N, Yasui K, Imai S, Isemura M, Yokogoshi H, Nakayama T.  Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine  J Sci Food Agric  2012  92(4):857-61  PubMed ID: 21969243
12724  Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M.  Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients  Ann Surg Oncol  2012  19 Suppl 3:S518-27  PubMed ID: 21845497
12729  Ogura J, Kuwayama K, Takaya A, Terada Y, Tsujimoto T, Koizumi T, Maruyama H, Fujikawa A, Takahashi N, Kobayashi M, Itagaki S, Hirano T, Yamaguchi H, Iseki K.  Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP  J Pharm Pharm Sci  2012  15(2):295-304  PubMed ID: 22579008
12731  Shinobu WATANABE, Takuya KATSUBE, Kenji SONOMOTO  Cholesterol-lowering Effects of Lactobacillus brevis Isolated from Turnip “Tsuda Kabu”  Food Science and Technology Research  2012  18:825-834 
12732  Tagashira T, Choshi T, Hibino S, Kamishikiryou J, Sugihara N.  Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate  J Food Sci  2012  77(10):H208-15  PubMed ID: 22938538
12733  Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.  A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers  Biol Pharm Bull  2012  35(1):1-9  PubMed ID: 22223330
12740  Chaisowwong W, Kusumoto A, Hashimoto M, Harada T, Maklon K, Kawamoto K.  Physiological characterization of Campylobacter jejuni under cold stresses conditions: its potential for public threat  J Vet Med Sci  2012  74(1):43-50  PubMed ID: 21891974
7607  Kimura O, Tsukagoshi K, Hayasaka M, Endo T.  Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.  Basic Clin. Pharmacol. Toxicol.  2011  110:530-6  PubMed ID: 22181038
7622  Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.  Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.  Biol. Pharm. Bull.  2011  34:1885-9  PubMed ID: 22130247
7653  Yasui K, Tanabe H, Miyoshi N, Suzuki T, Goto S, Taguchi K, Ishigami Y, Paeng N, Fukutomi R, Imai S, Isemura M.  Effects of (-)-epigallocatechin-3-O-gallate on expression of gluconeogenesis-related genes in the mouse duodenum.  Biomed. Res.  2011  32:313-20  PubMed ID: 22033300
7668  Isshiki M, Umezawa K, Tamura H.  Coffee induces breast cancer resistance protein expression in Caco-2 cells.  Biol. Pharm. Bull.  2011  34:1624-7  PubMed ID: 21963506
7735  Mitsuyama K, Niwa M, Masuda J, Kuwaki K, Yamasaki H, Takedatsu H, Kobayashi T, Sata M.  Isolation and characterization of a novel short peptide associated with Crohn's disease.  Clin. Exp. Immunol.  2011  166:72-9  PubMed ID: 21797848
7749  Ashida N, Yanagihara S, Shinoda T, Yamamoto N.  Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.  J. Biosci. Bioeng.  2011  112:333-7  PubMed ID: 21763196
7783  Kimura O, Kotaki Y, Hamaue N, Haraguchi K, Endo T.  Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers.  Food Chem. Toxicol.  2011  49:2167-71  PubMed ID: 21672599
7820  Horie A, Sakata J, Nishimura M, Ishida K, Taguchi M, Hashimoto Y.  Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.  Biopharm Drug Dispos  2011  32:253-60  PubMed ID: 21567399
7988  Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.  Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.  J. Agric. Food Chem.  2011  59:1470-6  PubMed ID: 21226458
8039  Tsuruta H, Yagishita T, Shimizu M, Tamura H.  Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2.  Toxicol In Vitro  2011  25:500-4  PubMed ID: 21144891
8051  Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S.  Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.  J. Biol. Chem.  2011  286:2750-61  PubMed ID: 21084306
9083  Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai  Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis  Infect Immun  2011  79 (11), 4353-60  PubMed ID: 21911469
9085  Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda  Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli  Gene  2011  478 (1-2), 1-10  PubMed ID: 21262333
12742  Takeda S, Yamasaki K, Takeshita M, Kikuchi Y, Tsend-Ayush C, Dashnyam B, Ahhmed AM, Kawahara S, Muguruma M.  The investigation of probiotic potential of lactic acid bacteria isolated from traditional Mongolian dairy products  Anim Sci J  2011  82(4):571-9  PubMed ID: 21794017
12744  Okumura S, Saitoh H, Ishikawa T, Inouye K, Mizuki E.  Mode of action of parasporin-4, a cytocidal protein from Bacillus thuringiensis  Biochim Biophys Acta  2011  1808(6):1476-82  PubMed ID: 21073856
8119  Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M.  Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy.  JPEN J Parenter Enteral Nutr  2010  34:530-7  PubMed ID: 20852181
8137  Wang C, Ho PC, Lim LY.  Wheat germ agglutinin-conjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells.  Int J Pharm  2010  400:201-10  PubMed ID: 20804835
8144  Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.  Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition.  Cell. Physiol. Biochem.  2010  26:125-34  PubMed ID: 20798496
8156  Watanabe K, Kamata K, Sato J, Takahashi T.  Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption.  J Ethnopharmacol  2010  132:193-9  PubMed ID: 20713144
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387
8386  Takahashi T, Kaku T, Sato T, Watanabe K, Sato J.  Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2.  J Nat Med  2010  64:55-62  PubMed ID: 20091240
12749  Shirou Itagaki et al.  Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2  Food Chemistry  2010  120(2):552-555 
12766  Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T.  Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer   Cell Physiol Biochem  2010  54(8):1182-91  PubMed ID: 20112302
12751  Nagamatsu Y, Okamura S, Saitou H, Akao T, Mizuki E.  Three Cry toxins in two types from Bacillus thuringiensis strain M019 preferentially kill human hepatocyte cancer and uterus cervix cancer cells  Biosci Biotechnol Biochem  2010  74(3):494-8  PubMed ID: 20208360
12752  Mari Takaai, Jumpei Sakata, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto  Mechanisms for Transport of Methotrexate across Apical and Basolateral Membranes in Human Intestinal Epithelial Caco-2 Cells  ryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)  2010  36:63 
12753  Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y, Nishimura Y.  The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy  Int J Cancer  2010  126(9):2153-63  PubMed ID: 19688828
8429  Narita K, Kawate T, Kakinuma N, Takeda S.  Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium.  Traffic  2009  11:287-301  PubMed ID: 19958467
8476  Yamanashi Y, Takada T, Suzuki H.  In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.  Pharmacogenet. Genomics  2009  19:884-92  PubMed ID: 19823104
8512  Yoshimura S, Kawano K, Matsumura R, Sugihara N, Furuno K.  Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.  J. Biomed. Biotechnol.  2009  2009:467489  PubMed ID: 19688110
8569  Kimura O, Tsukagoshi K, Endo T.  Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters.  Toxicol. Lett.  2009  189:102-9  PubMed ID: 19465094
8666  Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T.  Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors.  J. Gastroenterol.  2009  44:56-65  PubMed ID: 19159073
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
12761  Sugawara T, Yamashita K, Asai A, Nagao A, Shiraishi T, Imai I, Hirata T.  Esterification of xanthophylls by human intestinal Caco-2 cells  Arch Biochem Biophys  2009  483(2):205-12  PubMed ID: 18952044
12762  Ishida K, Taguchi M, Akao T, Hashimoto Y.  Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in beta-naphthoflavone-treated Caco-2 cells  Biol Pharm Bull   2009  32(3):513-6  PubMed ID: 19252307
12763  Kazuhiro Yamamoto, Hideki Hakamata, Akira Yamaguchi, Fumiyo Kusu  An LC method for monitoring medium-chain fatty acid permeation through CaCo-2 cell monolayers  Anal Bioanal Chem  2009  395(2):533-8  PubMed ID: 19641905
12765  Fukumori S, Masago M, Ishida K, Kayano Y, Taguchi M, Hashimoto Y.  Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells  Biopharm Drug Dispos  2009  30(8):448-56  PubMed ID: 19725017
12773  Kitamura Y, Kurosawa G, Tanaka M, Sumitomo M, Muramatsu C, Eguchi K, Akahori Y, Iba Y, Tsuda H, Sugiura M, Hattori Y, Kurosawa Y.  Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma  Biochem Biophys Res Commun  2009  383(4):480-4  PubMed ID: 19371721
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405
8757  Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.  Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.  Biol. Pharm. Bull.  2008  31:949-54  PubMed ID: 18451525
10207  Ayako Saruwatari, Shigeaki Okamura, Yoko Nakajima, Yuji Narukawa, Tadahiro Takeda, Hiroomi Tamura  Pomegranate Juice Inhibits Sulfoconjugation in Caco-2 Human Colon Carcinoma Cells  J Med Food  2008  11(4):623-8  PubMed ID: 19053852
12774  Saruwatari A, Isshiki M, Tamura H.  Inhibitory effects of various beverages on the sulfoconjugation of 17beta-estradiol in human colon carcinoma Caco-2 cells  iol Pharm Bull   2008  31(11):2131-6  PubMed ID: 18981586
12775  Seki T, Harada S, Hosoya O, Morimoto K, Juni K.  Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes  Biol Pharm Bull   2008  31(1):163-6  PubMed ID: 18175963
12776  Kimura O, Tsukagoshi K, Endo T.  Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter  Toxicol Appl Pharmacol  2008  227(3):325-30  PubMed ID: 18096194
12777  Kimura H, Yamamoto T, Sakai H, Sakai Y, Fujii T.  An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models  Lab Chip  2008  8(5):741-6  PubMed ID: 18432344
12778  Han Y, Chin Tan TM, Lim LY.  In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression  Toxicol Appl Pharmacol  2008  230(3):283-9  PubMed ID: 18417181
12779  Fukumori S, Murata T, Takaai M, Tahara K, Taguchi M, Hashimoto Y.  The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells  Drug Metab Pharmacokinet  2008  23(5):373-8  PubMed ID: 18974615
12780  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.  Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia  J Lipid Res  2008  49(4):763-72.  PubMed ID: 18180267
12781  Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y.  The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption  Cell Microbiol  2008  10(2):355-64  PubMed ID: 17868282
12785  Takaai M, Morishita H, Ishida K, Taguchi M, Hashimoto Y.  Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells  Eur J Pharmacol  2008  601(1-3):61-5  PubMed ID: 19013148
12786  Kadowaki M, Sugihara N, Tagashira T, Terao K, Furuno K.  Presence or absence of a gallate moiety on catechins affects their cellular transport  J Pharm Pharmacol  2008  60(9):1189-95  PubMed ID: 18718123
12788  Shah AK, Kinoshita M, Kurihara H, Ohnishi M, Takahashi K.  Glycosylceramides obtain from the starfish Asterias amurensis Lütken  J Oleo Sci  2008  57(9):477-84  PubMed ID: 18685230
12791  Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.  Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity  Biol Pharm Bull  2008  31(10):1933-7  PubMed ID: 18827358
12796  Chono S, Takeda E, Seki T, Morimoto K.  Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin  Int J Pharm  2008  347(1-2):71-8  PubMed ID: 17689212
8807  Katsube T, Tsuji H, Onoda M.  Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.  Biochim. Biophys. Acta  2007  1773:794-803  PubMed ID: 17451824
8846  Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.  Br. J. Pharmacol.  2007  150:209-19  PubMed ID: 17160010
3580  Ito T, Maki N, Hazeki O, Sasaki K, Nekooki M.  Extracellular and transmembrane region of a podocalyxin-like protein 1 fragment identified from colon cancer cell lines.  Cell Biol Int  2007  31(12):1518-24  PubMed ID: 17719804
3692  Arimochi J, Ohashi-Kobayashi A, Maeda M.  Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.  Biol Pharm Bull  2007  30(4):648-54  PubMed ID: 17409496
3599  Tachibana S, Hirano M, Hirata T, Matsuo M, Ikeda I, Ueda K, Sato R.  Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.  Biosci Biotechnol Biochem  2007  71(8):1886-95  PubMed ID: 17690481
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453
9062  Hitoshi HORIE, Yuichi FUJII, Kouji KATABAMI, Masanori IWAMA, Akira YAMADA  Suppressive effects of traditional herbal medicines on reversion of attenuated polio vaccine viruses to neurovirulent genotype  Journal of Traditional Medicines  2007  24: 156-163 
11676  Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, Tomohiro Hosoi  Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid  Biosci Biotechnol Biochem  2007  71(10):2428-34  PubMed ID: 17928716
12815  Satoko GUNJI, Joko SANTOSO, Yumiko YOSHIE-STARK, Takeshi SUZUKI  Effects of Extracts from Tropical Seaweeds on DPPH Radicals and Caco-2 Cells Treated with Hydrogen Peroxide  Food Science and Technology Research  2007  13:275-279 
12799  Oda M, Fujimoto K, Kobayashi M, Saitoh H.  Bacampicillin uptake is shared with thiamine in Caco-2 cells  Biol Pharm Bull   2007  30(7):1344-9  PubMed ID: 17603179
12800  Sugihara N, Toyama K, Okamoto T, Kadowaki M, Terao K, Furuno K.  Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach  Toxicol In Vitro  2007  21(5):827-34  PubMed ID: 17408918
12801  Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y.  Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers  Biol Pharm Bull . 2007 Nov;30(11):2167-72  2007  30(11):2167-72  PubMed ID: 17978494
12802  Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M.  TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation  World J Gastroenterol  2007  13(19):2717-21  PubMed ID: 17569141
12804  Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y.  Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells  Biol Pharm Bull  2007  30(10):1930-3  PubMed ID: 17917264
12805  Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.  Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro  Am J Physiol Gastrointest Liver Physiol  2007  292(3):G923-9  PubMed ID: 17170030
12807  Katayama H, Kusaka Y, Yokota H, Akao T, Kojima M, Nakamura O, Mekada E, Mizuki E.  Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells  J Biol Chem  2007  282(10):7742-52  PubMed ID: 17204466
12810  Tomoki Nakano, Tomomi Goto, Tarushige Nakaji, Takayoshi Aoki  Bioavailability of Iron-fortified Whey Protein Concentrate in Iron-deficient Rats  Asian-Australasian Journal of Animal Sciences  2007  20(7): 1120-1126 
12811  Amioka K, Kuzuya T, Kushihara H, Ejiri M, Nitta A, Nabeshima T.  Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport  J Pharm Pharmacol  2007  59(10):1383-7  PubMed ID: 17910813
3432  Nakamura, Masato, Kawakita, Yasunori, Yasuhara, Akito, Fukasawa, Yoshiki, Yoshida, Koji, Sakagami, Kazunari, Nakazato, Atsuro  In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarb oxylic Acid), a potent metabotropic glutamate receptor antagonist.  Drug Metab Dispos  2006  34:369-74  PubMed ID: 16326817
3404  Yoshida, Naoko, Takagi, Akiyoshi, Kitazawa, Hidenori, Kawakami, Junichi, Adachi, Isao  Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo.  J Pharm Sci  2006  95:552-60  PubMed ID: 16419049
8890  Moriya Y, Nakamura T, Okamura N, Sakaeda T, Horinouchi M, Tamura T, Aoyama N, Kasuga M, Okumura K.  Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.  Biol. Pharm. Bull.  2006  29:535-8  PubMed ID: 16508161
12816  Han Y, Tan TM, Lim LY.  Effects of capsaicin on P-gp function and expression in Caco-2 cells  Biochem Pharmacol  2006  71(12):1727-34  PubMed ID: 16674925
12817  Watanabe K, Jinriki T, Sato J.  Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2  Biol Pharm Bull  2006  29(1):90-5  PubMed ID: 16394517
12818  Sugawara T, Zaima N, Yamamoto A, Sakai S, Noguchi R, Hirata T.  Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells  Biosci Biotechnol Biochem  2006  70(12):2906-12  PubMed ID: 17151482
12819  Seki T, Kanbayashi H, Nagao T, Chono S, Tabata Y, Morimoto K.  Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers  J Pharm Sci  2006  95(6):1393-401  PubMed ID: 16625653
12820  M Gueimonde et al  Adhesion and competitive inhibition and displacement of human enteropathogens by selected lactobacilli  Food Research International  2006  39:467-471 
12821  Sugihara N, Toyama K, Michihara A, Akasaki K, Tsuji H, Furuno K.  Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer  Toxicology  2006  223(1-2):156-65  PubMed ID: 16647797
12822  Ishida K, Takaai M, Hashimoto Y.  Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells  Biol Pharm Bull  2006  29(3):522-6  PubMed ID: 16508158
12823  Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells  Apoptosis-inducing Activity of Hot Water Extracts from the Sea Cucumber in Human Colon Tumor Cells  Food Science and Technology Research  2006  12:290-294 
12824  Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y.  Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines  J Gastroenterol  2006  2006 Feb;41(2):140-50  PubMed ID: 16568373
12825  Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K, Fujimoto Y, Kohgo Y.  Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF  Hepatol Res  2006  35(3):152-62  PubMed ID: 16707273
12826  Okumura S, Saitoh H, Wasano N, Katayama H, Higuchi K, Mizuki E, Inouye K.  Efficient solubilization, activation, and purification of recombinant Cry45Aa of Bacillus thuringiensis expressed as inclusion bodies in Escherichia coli  Protein Expr Purif   2006  47(1):144-51  PubMed ID: 16307894
12827  Makoto KIMURA, Kuninaga DANNO, Hisako YASUI  Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk  Bioscience and Microflora  2006  25:147-155 
12828  Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S.  Determination of p-glycoprotein ATPase activity using luciferase  Biol Pharm Bull   2006  29(3):560-4  PubMed ID: 16508168
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879
3026  Aiba T, Susa M, Fukumori S, Hashimoto Y  The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180  Drug Metab Pharmacokinet  2005  20:268-274  PubMed ID: 16141606
3025  Aiba, Tetsuya, Ishida, Kazuya, Yoshinaga, Mariko, Okuno, Marie, Hashimoto, Yukiya  Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.  Biol Pharm Bull  2005  28:114-9  PubMed ID: 15635174
3072  Koyama, Yu, Suzuki, Takuji, Kajiya, Akane, Isemura, Mamoru  Stimulation of IL-8 production by Aralia cordate lectin in human colon carcinoma Caco-2 cells.  Biosci Biotechnol Biochem  2005  69:202-5  PubMed ID: 15665486
3300  Kanno, Syu-Ichi, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Shouji, Ai, Ujibe, Mayuko, Ohtake, Takaharu, Kimura, Katsuhiko, Ishikawa, Masaaki  Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.  Biol Pharm Bull  2005  28:527-30  PubMed ID: 15744083
3155  Innami, Satoshi, Ishida, Hiroshi, Nakamura, Kahoru, Kondo, Mika, Tabata, Kimiko, Koguchi, Takashi, Shimizu, Jun, Furusho, Tadasu  Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.  Int J Vitam Nutr Res  2005  75:39-46  PubMed ID: 15830920
3164  Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923
3270  Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.  Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.  Hepatol. Res.  2005  33:198-205  PubMed ID: 16198622
9134  Piyawan Bunpo, B.Sc., Keiko Kataoka, Ph.D., Hideki Arimochi, Ph.D., Haruyuki Nakayama, M.Sc., Tomomi Kuwahara, Ph.D., Yoshinari Ohnishi, Ph.D., Usanee Vinitketkumnuen, Ph.D.  CENTELLA ASIATICA EXTRACT INDUCES CELL CYCLE ARREST IN CACO-2 HUMAN COLON CANCER CELLS  Chiang Mai Med Bull  2005  44:21-28 
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112
12832  Mariko OGUSHI, Yumiko YOSHIE-STARK, Takeshi SUZUKI  Cytostatic Activity of Hot Water Extracts from the Sea Cucumber in Caco-2  Food Science and Technology Research  2005  11:202-206 
12833  Okamura S, Suzuki K, Yanase M, Koizumi M, Tamura HO.  The effects of coffee on conjugation reactions in human colon carcinoma cells  Biol Pharm Bull   2005  28(2):271-4  PubMed ID: 15684482
12835  Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.  Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene  Biochim Biophys Acta  2005  1732(1-3):43-52  PubMed ID: 16380173
2720  Saegusa S, Totsuka M, Kaminogawa S, Hosoi T  Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid.  FEMS Immunol Med Microbiol  2004  41:227-35  PubMed ID: 15196572
2736  Watanabe, Kazuhiro, Terada, Kazuaya, Jinriki, Toshiya, Sato, Juichi  Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2.  Eur J Pharm Sci  2004  21:87-95  PubMed ID: 14706815
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424
2735  Watanabe, Kazuhiro, Jinriki, Toshiya, Sato, Juichi  Effects of progesterone and norethisterone on cephalexin uptake in the human intestinal cell line Caco-2.  Biol Pharm Bull  2004  27:559-63  PubMed ID: 15056866
3199  Minekawa, Ryoko, Takeda, Takashi, Sakata, Masahiro, Hayashi, Masami, Isobe, Aki, Yamamoto, Toshiya, Tasaka, Keiichi, Murata, Yuji  Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells.  Am J Physiol Cell Physiol  2004  287:C1404-11  PubMed ID: 15229109
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
3094  Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu  Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res  2004  64:6410-5  PubMed ID: 15374948
2708  Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153
3066  Aida K. et al.  Apoptosis Inducement by plant and fungus sphingoid beses in human colon cancer cells.  J Oleo Sci.  2004  53:503-510 
4723  Minagawa N, Nakayama Y, Inoue Y, Onitsuka K, Katsuki T, Tsurudome Y, Shibao K, Hirata K, Sako T, Nagata N, Ohie S, Kohno K, Itoh H.  4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.  Oncol Res  2004  14(9):407-14  PubMed ID: 15490972
12839  Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M.  Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells  Biosci Biotechnol Biochem  2004  68(12):2541-6  PubMed ID: 15618625
12840  Shigeaki Okamura, Hiro-omi Tamura  Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2  Journal of Health Science  2004  50:189-192 
12842  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity  Altern Lab Anim  2004  32 Suppl 1A:99-103  PubMed ID: 23577440
12843  Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T.  Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids  Cell Transplant  2004  13(4):463-73  PubMed ID: 15468688
12844  Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.  The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics  Biochem Pharmacol  2004  67(5):989-1000  PubMed ID: 15104253
2645  Hosoi, Tomohiro, Hirose, Rieko, Saegusa, Shizue, Ametani, Akio, Kiuchi, Kan, Kaminogawa, Shuichi  Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto).  Int J Food Microbiol  2003  82:255-64  PubMed ID: 12593928
3042  Shimizu, Takeshi, Hamabata, Takashi, Yoshiki, Akemi, Hori, Takeya, Ito, Satoru, Takeda, Yoshifumi, Hayashi, Hideo  An association of 27- and 40-kDa molecules with glycolipids that bind A-B bacterial enterotoxins to cultured cells.  Biochim Biophys Acta  2003  1612:186-94  PubMed ID: 12787937
3791  Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K.  Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.  Pharm Res  2003  20(2):324-7  PubMed ID: 12636175
3792  Takaishi S, Sawada M, Seno H, Kayahara T, Morita-Fujisawa Y, Fukuzawa H, Chiba T.  Growth promoting effect of thioredoxin on intestinal epithelial cells.  Dig Dis Sci  2003  48(2):379-85  PubMed ID: 12643619
3794  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.  J Artif Organs  2003  6(4):273-81  PubMed ID: 14691670
3796  Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, Takamoto S, Murakami Y.  Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.  Int J Cancer  2003  107(1):53-9  PubMed ID: 12925956
2734  Watanabe, Kazuhiro, Sawano, Tetsuya, Terada, Kazuaya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:885-90  PubMed ID: 12132663
2629  Ohama, Tohru, Hirano, Ken-ichi, Zhang, Zhongyan, Aoki, Ryo, Tsujii, Ken-ichi, Nakagawa-Toyama, Yumiko, Tsukamoto, Kosuke, Ikegami, Chiaki, Matsuyama, Akifumi, Ishigami, Masato, Sakai, Naohiko, Hiraoka, Hisatoyo, Ueda, Kazumitsu, Yamashita, Shizuya, Matsuzawa, Yuji  Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands.  Biochem Biophys Res Commun  2002  296:625-30  PubMed ID: 12176027
2633  Watanabe, Kazuhiro, Sawano, Tetsuya, Endo, Tetsuya, Sakata, Masakatsu, Sato, Juichi  Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.  Biol Pharm Bull  2002  25:1345-50  PubMed ID: 12392092
3750  Morita H1, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.  Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.  Microbiol Immunol  2002  46(4):293-7  PubMed ID: 12061632
3779  Yamauchi K, Komatsu T, Kulkarni AD, Ohmori Y, Minami H, Ushiyama Y, Nakayama M, Yamamoto S.  Glutamine and arginine affect Caco-2 cell proliferation by promotion of nucleotide synthesis.  Nutrition  2002  18(4):329-33  PubMed ID: 11934546
3781  Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ.  Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells.  Biol Pharm Bull  2002  25(3):393-6  PubMed ID: 11913542
3783  Noda M, Tatsumi Y, Tomizawa M, Takama T, Mitsufuji S, Sugihara H, Kashima K, Hattori T.  Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.  J Gastroenterol  2002  37(11):896-904  PubMed ID: 12483244
2554  Tamura, H., and Matsui, M.  Effects of Phenolic Enviromental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2  J Health Science  2001  47:468-472 
2544  Todoriki K, Mukai T, Sato S, Toba T  Inhibition of adhesion of food-borne pathogens to Caco-2 cells by Lactobacillus strains.  J Appl Microbiol  2001  91:154-9  PubMed ID: 11442725
2553  Isozaki T, Tamura H  Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2001  24:1076-8  PubMed ID: 11558573
2550  Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62  PubMed ID: 11725959
3768  Takeuchi K, Mizuno M, Uesu T, Nasu J, Kawada M, Hori S, Okada H, Endo Y, Fujita T, Tsuji T.  Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway.  J Lab Clin Med  2001  138(3):186-92  PubMed ID: 11528371
3771  Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.  DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.  Cancer Genet Cytogenet  2001  126(1):34-8  PubMed ID: 11343776
3772  Ijichi H, Ikenoue T, Kato N, Mitsuno Y, Togo G, Kato J, Kanai F, Shiratori Y, Omata M.  Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells.  Biochem Biophys Res Commun  2001  289(2):350-7  PubMed ID: 11716479
3774  Kawabata S, Oka M, Shiozawa K, Tsukamoto K, Nakatomi K, Soda H, Fukuda M, Ikegami Y, Sugahara K, Yamada Y, Kamihira S, Doyle LA, Ross DD, Kohno S.  Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.  Biochem Biophys Res Commun  2001  280(5):1216-23  PubMed ID: 11162657
2551  Tamura H, Matsui M  Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2000  23:695-9  PubMed ID: 10864017
2552  Satoh T, Matsui M, Tamura H  Sulfotransferases in a human colon carcinoma cell line, Caco-2.  Biol Pharm Bull  2000  23:810-4  PubMed ID: 10919357
3780  Endo T, Kimura O, Saitoh H, Sakata M.  Secretory transport of cadmium through intestinal brush border membrane via H(+)-antiport.  Toxicology  2000  150(1-3):129-36  PubMed ID: 10996669
3761  Nakayama A, Saitoh H, Oda M, Takada M, Aungst BJ.  Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system.  Eur J Pharm Sci  2000  11(4):317-24  PubMed ID: 11033075
3763  Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.  Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.  Biochem Biophys Res Commun  2000  19;267(2):658-62  PubMed ID: 10631118
3758  Miyata R, Iwabuchi K, Watanabe S, Sato N, Nagaoka I.  Short exposure of intestinal epithelial cells to TNF-alpha and histamine induces Mac-1-mediated neutrophil adhesion independent of protein synthesis.  J Leukoc Biol  1999  66(3):437-46  PubMed ID: 10496314
2273  Kanda T, Foucand L, Nakamura Y, Niot I, Besnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H  Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells  Biochem J  1998  330:261-265  PubMed ID: 9461519
12856  Tsuji S, Kawano S, Sawaoka H, Takei Y, Kobayashi I, Nagano K, Fusamoto H, Kamada T.  Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines  Prostaglandins Leukot Essent Fatty Acids  1996  ;55(3):179-83  PubMed ID: 8931116

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