Cell No. : Cell Name RCB0987 : C2C12  update : 2025/06/09
Comment			Said differentiate to myotubes, but need confirmation. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 91031101 prior to order.
Comment from the depositor
Terms and conditions			1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA91031101 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	ECACC
		Year of deposit	1994
		Animal	_mouse < Mammals
		Strain name	C3H
		Tissue	muscle
		Classification	other
		History	overseas, ECACC
		Lifespan	infinite
		Morphology	other
		Cellosaurus(Expasy)	CVCL_0188
			deposit info	lot info
		Medium	Medium List
		Culture type		Adherent cells
		Culture medium		DMEM (low glucose) + 10% FBS
		Antibiotics		Free
		Passage method		0.25% Trypsin
	Culture information	Passage ratio		1 : 10-20 split
		SC frequency		Subculture : once/2-3 days
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma/Acholeplasma		(-)
		Animal PCR		OK
		SSLP(mouse)		OK
Images			deposit info	lot info
Reference information		Reference	3
		User's Publication	371

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Reference

4921  atagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T.  Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.  J Cell Biol  1994  127(6 Pt 1):1755-66.  PubMed ID: 7798324   DOI: 10.1083/jcb.127.6.1755

4920  Blau HM, Pavlath GK, Hardeman EC, Chiu CP, Silberstein L, Webster SG, Miller SC, Webster C.  Plasticity of the differentiated state.  Science  1985  230(4727):758-66  PubMed ID: 2414846   DOI: 10.1126/science.2414846

1832  Yaffe D, Saxel O  Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle.  Nature  1977  270:725-7  PubMed ID: 563524   DOI: 10.1038/270725a0

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User's Publication

22473  Hattori M, Wazawa T, Orioka M, Hiruta Y, Nagai T.  Creating coveted bioluminescence colors for simultaneous multi-color bioimaging.  Sci Adv  2025  11(4):eadp4750  PubMed ID: 39841832   DOI: 10.1126/sciadv.adp4750

22735  Kumeta M, Otani M, Toyoda M, Yoshimura SH.  Acoustic modulation of mechanosensitive genes and adipocyte differentiation.  Commun Biol  2025  8(1):595  PubMed ID: 40240542   DOI: 10.1038/s42003-025-07969-1

22738  Shirai T, Uemichi K, Iwai R, Shinkai H, Iwata T, Tanimura R, Sugiyama S, Takemasa T.  Systemic effect of combined functional overload and endurance-type swimming exercise on whole-body metabolism in mice.  Am J Physiol Endocrinol Metab  2025    PubMed ID: 40248969   DOI: 10.1152/ajpendo.00433.2024

22739  Kawaguchi Y, Kataoka Y, Okamoto K, Yoden M, Shiratori T, Kaku R, Ueda K, Ohshio Y, Terashima T, Hanaoka J.  Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients.  Sci Rep  2025  15(1):13641  PubMed ID: 40254615   DOI: 10.1038/s41598-025-97907-2

22784  Matsuhashi S, Choisez A, Xu Y, Firouzjah SD, Harada K, Zeng L, Osana S, Takada H, Nagatomi R, Kusuyama J.  Signaling balance of MCTs and GPR81 controls lactate-induced metabolic function and cell death in skeletal muscle cells through Ranbp3l/Nfat5 and Atf4.  Cell Signal  2025  111852  PubMed ID: 40318798   DOI: 10.1016/j.cellsig.2025.111852

22820  Ikeda M, Matsumoto M, Tamura M, Kobayashi M, Iida K.  Glucose, glutamine, lactic acid and α‑ketoglutarate restore metabolic disturbances and atrophic changes in energy‑deprived muscle cells.  Mol Med Rep  2025  32(1)  PubMed ID: 40376969   DOI: 10.3892/mmr.2025.13562

22967  Tu-Shen Chen H, Shiwaku Y, Hamai R, Tsuchiya K, Yamauchi K, Takahashi T, Suzuki O.  C2C12 myoblast differentiation stimulated by octacalcium phosphate material.  Dent Mater J  2025    PubMed ID: 40500213   DOI: 10.4012/dmj.2024-382

19858  Mohamad Ishak NS, Kikuchi M, Ikemoto K.  Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells  Front Aging  2024  5:1351860  PubMed ID: 38487591   DOI: 10.3389/fragi.2024.1351860

21473  Hirai T, Wang W, Murono N, Iwasa K, Inoue M.  Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine.  J Nat Med  2024  78(1):169-179  PubMed ID: 37951850   DOI: 10.1007/s11418-023-01755-1

21611  Fu X, Murakami M, Hashimoto O, Matsui T, Funaba M.  Regulatory mechanisms underlying interleukin-6 expression in murine brown adipocytes.  Cell Biochem Funct  2024  42(1):e3915  PubMed ID: 38269513   DOI: 10.1002/cbf.3915

21625  Jo-Watanabe A, Inaba T, Osada T, Hashimoto R, Nishizawa T, Okuno T, Ihara S, Touhara K, Hattori N, Oh-Hora M, Nureki O, Yokomizo T.  Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury.  Nat Commun  2024  15(1):1530  PubMed ID: 38413581   DOI: 10.1038/s41467-024-45579-3

21656  Kashiwagi R, Udono M, Katakura Y.  Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells.  Cytotechnology  2024  76(2):209-216  PubMed ID: 38495295   DOI: 10.1007/s10616-023-00610-1

21713  Furuno K, Suzuki K, Sakai S.  Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics.  Biomolecules  2024  14(4)  PubMed ID: 38672522   DOI: 10.3390/biom14040506

21756  Othman MB, Takeda R, Sekita M, Okazaki K, Sakamoto K.  Amber (Succinite) Extract Enhances Glucose Uptake through the Up-Regulation of ATP and Down-Regulation of ROS in Mouse C2C12 Cells.  Pharmaceuticals (Basel)  2024  17(5)  PubMed ID: 38794156   DOI: 10.3390/ph17050586

21760  Noguchi I, Maeda H, Kobayashi K, Nagasaki T, Kato H, Yanagisawa H, Wada N, Kanazawa G, Kaji T, Sakai H, Fujimaki S, Ono Y, Taguchi K, Chuang VTG, Saruwatari J, Otagiri M, Watanabe H, Maruyama T.  Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment.  Free Radic Biol Med  2024  220:67-77  PubMed ID: 38657755   DOI: 10.1016/j.freeradbiomed.2024.04.231

21798  Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R.  Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.  JCI Insight  2024  9(11)  PubMed ID: 38855864   DOI: 10.1172/jci.insight.175486

21809  Zhang R, Farshadyeganeh P, Ohkawara B, Nakajima K, Takeda JI, Ito M, Zhang S, Miyasaka Y, Ohno T, Mori-Yoshimura M, Masuda A, Ohno K.  Muscle-specific lack of GFPT1 in knock-in mice triggers ER stress to alleviate misfolded proteins.  Dis Model Mech  2024    PubMed ID: 38903011   DOI: 10.1242/dmm.050768

21880  Okura T, Ito Y, Anno M, Endo S, Kitao S, Nakamura R, Matsumoto K, Shoji K, Okura H, Matsuzawa K, Izawa S, Ichihara Y, Ueta E, Kato M, Imamura T, Taniguchi SI, Yamamoto K.  Postprandial fatty acid-binding protein 4 is associated with muscle insulin resistance.  Diabetologia  2024    PubMed ID: 39060707   DOI: 10.1007/s00125-024-06222-4

21881  Tabe S, Hikiji H, Hashidate-Yoshida T, Shindou H, Shimizu T, Tominaga K.  The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells.  FEBS Open Bio  2024    PubMed ID: 39075841   DOI: 10.1002/2211-5463.13845

21885  Fujiki J, Naoyuki M, Yamaguchi K, Ohtsuki Y, Iwano H.  DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts.  Mol Cell Endocrinol  2024    PubMed ID: 39094930   DOI: 10.1016/j.mce.2024.112336

21951  Nishida R, Nukaga S, Kawahara I, Miyagawa Y, Goto K, Nakashima C, Luo Y, Sasaki T, Fujii K, Ohmori H, Ogata R, Mori S, Fujiwara-Tani R, Kuniyasu H.  Differential Effects of Three Medium-Chain Fatty Acids on Mitochondrial Quality Control and Skeletal Muscle Maturation.  Antioxidants (Basel)  2024  13(7)  PubMed ID: 39061890   DOI: 10.3390/antiox13070821

21978  Hayashi Y, Kamimura-Aoyagi Y, Nishikawa S, Noka R, Iwata R, Iwabuchi A, Watanabe Y, Matsunuma N, Yuki K, Kobayashi H, Harada Y, Harada H.  IL36G-producing neutrophil-like monocytes promote cachexia in cancer.  Nat Commun  2024  15(1):7662  PubMed ID: 39266531   DOI: 10.1038/s41467-024-51873-x

22027  Morishima N, Ito Y.  Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation.  J Biol Chem  2024  107842  PubMed ID: 39357823   DOI: 10.1016/j.jbc.2024.107842

22163  Sato S, Hanai T, Kanamoto T, Kawano F, Hikida M, Yokoi H, Take Y, Magome T, Ebina K, Mae T, Tanaka H, Nakata K.  Vibration acceleration enhances proliferation, migration, and maturation of C2C12 cells and promotes regeneration of muscle injury in male rats.  Physiol Rep  2024  12(4):e15905  PubMed ID: 38396237   DOI: 10.14814/phy2.15905

22168  Miyauchi Y, Kiyama M, Soga S, Nanri H, Ogiwara T, Yonamine S, Kon R, Ikarashi N, Chiba Y, Hosoe T, Sakai H  Downregulation of Genes for Skeletal Muscle Extracellular Matrix Components by Cisplatin.  Biol Pharm Bull  2024  47(11):1846-1850  PubMed ID: 39522978   DOI: 10.1248/bpb.b24-00428

22230  Kanai M, Ganbaatar B, Endo I, Ohnishi Y, Teramachi J, Tenshin H, Higa Y, Hiasa M, Mitsui Y, Hara T, Masuda S, Yamagami H, Yamaguchi Y, Aihara KI, Sebe M, Tsutsumi R, Sakaue H, Matsumoto T, Abe M.  Inflammatory Cytokine-Induced Muscle Atrophy and Weakness Can Be Ameliorated by an Inhibition of TGF-β-Activated Kinase-1  Int J Mol Sci  2024  25(11):5715  PubMed ID: 38891908   DOI: 10.3390/ijms25115715

22231  Ito T, Rojasawasthien T, Takeuchi SY, Okamoto H, Okumura N, Shirakawa T, Matsubara T, Kawamoto T, Kokabu S.  Royal Jelly Enhances the Ability of Myoblast C2C12 Cells to Differentiate into Multilineage Cells  Molecules  2024  29(7):1449.  PubMed ID: 38611729   DOI: 10.3390/molecules29071449

22232  Yoshizaki H, Kawaharada R, Tsutsumi S, Okami H, Toriumi A, Miyata E, Nakamura A.  Unveiling the Threat of Maternal Advanced Glycation End Products to Fetal Muscle: Palmitoleic Acid to the Rescue  Nutrients  2024  16(12):1898  PubMed ID: 38931253   DOI: 10.3390/nu16121898

22242  Diao Z, Jia S, Itoyama E, Yoshioka H, Murakami M, Funaba M.  A possibility of uncoupling protein 1 induction with the enhancement of myogenesis related to ruminal fermentation.  Sci Rep  2024  14(1):29857  PubMed ID: 39622913   DOI: 10.1038/s41598-024-81272-7

22392  Kokabu S, Kodama N, Miyawaki A, Tsuji K, Hino J, Ono Y, Matsubara T.  Excessive BMP3b suppresses skeletal muscle differentiation.  Biochem Biophys Res Commun  2024  746:151261  PubMed ID: 39742789   DOI: 10.1016/j.bbrc.2024.151261

22627  Kobayashi Y, Kurokawa H, Tokinoya K, Matsui H.  Monascus pigment prevent the oxidative cytotoxicity in myotube derived hydrogen peroxide  J Clin Biochem Nutr  2024  75(1):33-39  PubMed ID: 39070528   DOI: 10.3164/jcbn.22-62

22693  Misaizu R, Endo-Takahashi Y, Nirasawa K, Negishi Y, Asayama S.  Diffusive delivery of plasmid DNA using zwitterionic carboxyalkyl poly(1-vinylimidazole) into skeletal muscle in vivo  Biomater Sci  2024  12(15):3947-3955  PubMed ID: 8949480   DOI: 10.1039/d4bm00510d

22709  Ohyama Y, Ohta Y, Sugama R, Minoda Y, Masuda S, Terai H, Nakamura H.  Effect of recombinant irisin on recombinant human bone morphogenetic protein-2 induced osteogenesis and osteoblast differentiation  Biochem Biophys Res Commun  2024  734:150787  PubMed ID: 39368373   DOI: 10.1016/j.bbrc.2024.150787

22811  Hiroki Miyazako, Kohei Tsuchiyama, Takaaki Nara  Predictive model of spatial nematic order in confined cell populations  npj Biological Physics and Mechanics  2024  1    DOI: 10.1038/s44341-024-00001-3

22867  Kitamura H, Fujimoto M, Hashimoto M, Yasui H, Inanami O.  USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts  Int J Mol Sci  2024  25(22):11936  PubMed ID: 39596006   DOI: 10.3390/ijms252211936

17751  Norikura T, Sasaki Y, Kojima-Yuasa A, Kon A.  Glyoxylic Acid, an α-Keto Acid Metabolite Derived from Glycine, Promotes Myogenesis in C2C12 Cells  Nutrients  2023  15(7):1763  PubMed ID: 37049603   DOI: 10.3390/nu15071763

17752  Nakagawara K, Takeuchi C, Ishige K.  5'-CMP and 5'-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes  Biochem Biophys Rep  2023  34:101460  PubMed ID: 37020790   DOI: 10.1016/j.bbrep.2023.101460

17753  Jing Z, Iba T, Naito H, Xu P, Morishige JI, Nagata N, Okubo H, Ando H.  L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy  Front Pharmacol   2023  14:1182788  PubMed ID: 37089945   DOI: 10.3389/fphar.2023.1182788

19559  Hirono Ohashi, Shunsuke Shigaki, Ryo Teramae, Masahiro Shimizu, Koh Hosoda  Development of Bio-cultured Artificial Muscles with High Design Flexibility  Journal of Bionic Engineering  2023  20:1635-1645    DOI: 10.1007/s42235-023-00355-9

19560  Elvitigala KCML, Mubarok W, Sakai S.  Tuning the crosslinking and degradation of hyaluronic acid/gelatin hydrogels using hydrogen peroxide for muscle cell sheet fabrication  Soft Matter  2023  19(31):5880-5887.  PubMed ID: 37439099   DOI: 10.1039/d3sm00560g

19561  Hayata Okino, Ryota Yamada, Shunta Muraki, Motonari Suzuki, Shinya Kumagai  Microperfusion cell culture system for promoted cell growth using non-thermal atmospheric pressure plasma exposure  Japanese Journal of Applied Physics  2023  62:SG1043    DOI: 10.35848/1347-4065/acc03c

19562  Kitakaze T, Tatsumi R, Yamaguchi M, Nakatsuji A, Harada N, Yamaji R.  All- Trans Retinoic Acid-Responsive LGR6 Is Transiently Expressed during Myogenic Differentiation and Is Required for Myoblast Differentiation and Fusion  Int J Mol Sci  2023  24(10):9035  PubMed ID: 37240382   DOI: 10.3390/ijms24109035

19656  Tanimoto A, Yamaguchi Y, Kadowaki T, Sakai E, Oyakawa S, Ono Y, Yoshida N, Tsukuba T.  Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport and mTORC1 signaling  J Cell Biochem  2023  124(10):1486-1502  PubMed ID: 37566644   DOI: 10.1002/jcb.30457

21013  Shintani-Ishida K, Tsurumi R, Ikegaya H.  Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.  PLoS One  2023  18(1):e0280527  PubMed ID: 36649291   DOI: 10.1371/journal.pone.0280527

21024  Araki H, Hino S, Anan K, Kuribayashi K, Etoh K, Seko D, Takase R, Kohrogi K, Hino Y, Ono Y, Araki E, Nakao M.  LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle.  Elife  2023    PubMed ID: 36695573   DOI: 10.7554/eLife.84618

21164  Matsuba I, Fujita R, Iida K.  Palmitic Acid Inhibits Myogenic Activity and Expression of Myosin Heavy Chain MHC IIb in Muscle Cells through Phosphorylation-Dependent MyoD Inactivation.  Int J Mol Sci  2023  24(6)  PubMed ID: 36982919   DOI: 10.3390/ijms24065847

21236  Sato K, Miyauchi Y, Xu X, Kon R, Ikarashi N, Chiba Y, Hosoe T, Sakai H.  Platinum-based anticancer drugs-induced downregulation of myosin heavy chain isoforms in skeletal muscle of mouse.  J Pharmacol Sci  2023  152(3):167-177  PubMed ID: 37257944   DOI: 10.1016/j.jphs.2023.04.009

21245  Iwai S, Kaji K, Nishimura N, Kubo T, Tomooka F, Shibamoto A, Suzuki J, Tsuji Y, Fujinaga Y, Kitagawa K, Namisaki T, Akahane T, Yoshiji H.  Glucagon-like peptide-1 receptor agonist, semaglutide attenuates chronic liver disease-induced skeletal muscle atrophy in diabetic mice.  Biochim Biophys Acta Mol Basis Dis  2023  166770  PubMed ID: 37276988   DOI: 10.1016/j.bbadis.2023.166770

21279  Takakura Y, Suzuki T, Hirai N, Araki T, Ohishi M, Sato H, Yamaguchi N, Takano H, Yamaguchi N.  VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes.  Biochem Biophys Res Commun  2023  669:30-37  PubMed ID: 37262950   DOI: 10.1016/j.bbrc.2023.05.073

21292  Endo S, Uto A, Miyashita K, Sato M, Inoue H, Fujii K, Hagiwara A, Ryuzaki M, Oshida T, Kinouchi K, Itoh H.  Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation.  J Endocr Soc  2023  7(7):bvad082  PubMed ID: 37362383   DOI: 10.1210/jendso/bvad082

21389  Sato K, Satoshi Y, Miyauchi Y, Sato F, Kon R, Ikarashi N, Chiba Y, Hosoe T, Sakai H.  Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle.  Biochim Biophys Acta Mol Basis Dis  2023  1870(1):166877  PubMed ID: 37673360   DOI: 10.1016/j.bbadis.2023.166877

21425  Kametaka S, Isobe M, Komata K, Morinaga M, Nagahata K, Lee-Hotta S, Uchiyama Y, Shibata M, Sugiura H.  Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice.  Biomed Res  2023  44(5):199-207  PubMed ID: 37779032   DOI: 10.2220/biomedres.44.199

21430  Mori K, Kataoka K, Akiyama Y, Asahi T.  Covalent Immobilization of Collagen Type I to a Polydimethylsiloxane Surface for Preventing Cell Detachment by Retaining Collagen Molecules under Uniaxial Cyclic Mechanical Stretching Stress.  Biomacromolecules  2023    PubMed ID: 37800307   DOI: 10.1021/acs.biomac.3c00669

21499  Minami E, Sasa K, Yamada A, Kawai R, Yoshida H, Nakano H, Maki K, Kamijo R.  Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.  PLoS One  2023  18(12):e0293676  PubMed ID: 38051708   DOI: 10.1371/journal.pone.0293676

21517  Toita R, Kitamura M, Tsuchiya A, Kang JH, Kasahara S.  Releasable, Immune-Instructive, Bioinspired Multilayer Coating Resists Implant-Induced Fibrosis while Accelerating Tissue Repair.  Adv Healthc Mater  2023  e2302611  PubMed ID: 38095751   DOI: 10.1002/adhm.202302611

21525  Kimira Y, Osawa K, Osawa Y, Mano H.  Preventive Effects of Collagen-Derived Dipeptide Prolyl-Hydroxyproline against Dexamethasone-Induced Muscle Atrophy in Mouse C2C12 Skeletal Myotubes.  Biomolecules  2023  13(11)  PubMed ID: 38002299   DOI: 10.3390/biom13111617

17501  Yasukuni R, Koyanagi A, Tanaka Y, Okano K, Hosokawa Y.  Cell viability assessment associated with a contact of gas bubbles produced by femtosecond laser breakdown in cell culture media  Sci Rep  2022  12(1):19001  PubMed ID: 36347928   DOI: 10.1038/s41598-022-23733-5

17552  Takasawa S, Shobatake R, Itaya-Hironaka A, Makino M, Uchiyama T, Sakuramoto-Tsuchida S, Takeda Y, Ota H, Yamauchi A.  Upregulation of IL-8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells  J Cell Mol Med  2022  ;26(24):6019-6031  PubMed ID: 36457269   DOI: 10.1111/jcmm.17618

17566  Kobayashi Y, Asayama S.  Design of the Zinc Ion and Plasmid DNA Co-Delivery System by Poly(1-Vinylimidazole) Derivatives for Myoblast Differentiation  ACS Appl Bio Mater  2022  5(12):5754-5761  PubMed ID: 36459414   DOI: 10.1021/acsabm.2c00737

17584  Suzuki M, Kimura T, Yoshida Y, Kobayashi M, Hashimoto Y, Takahashi H, Shimizu T, Anzai S, Nakamura N, Kishida A.  In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration  Polymers (Basel)  2022  14(12):2351  PubMed ID: 35745927   DOI: 10.3390/polym14122351

17589  Dian Anggraini, Wildan Mubarok, Yoichiroh Hosokawa, Koji Eto, Shiro Suetsugu, Yaxiaer Yalikun  Reverse sorting of immortalized megakaryocyte progenitor cell lines (imMKCLs) by femtosecond laser scanning  Applied Physics Express  2022  15:107001    DOI: 10.35848/1882-0786/ac8f17

17597  Sasaki Y, Kojima-Yuasa A, Tadano H, Mizuno A, Kon A, Norikura T.  Ursolic acid improves the indoxyl sulfate-induced impairment of mitochondrial biogenesis in C2C12 cells  Nutr Res Pract  2022  16(2):147-160  PubMed ID: 35392531   DOI: 10.4162/nrp.2022.16.2.147

17672  Imashiro C, Mei J, Friend J, Takemura K.  Quantifying cell adhesion through forces generated by acoustic streaming  Ultrason Sonochem  2022  90:106204  PubMed ID: 36257212   DOI: 10.1016/j.ultsonch.2022.106204

20454  Ishikawa K, Araki M, Nagano Y, Motoda A, Shishido T, Kurashige T, Takahashi T, Morino H, Kawakami H, Matsumoto M, Maruyama H.  Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions.  Differentiation  2022  123:1-8  PubMed ID: 34844057   DOI: 10.1016/j.diff.2021.11.004

20525  Hosaka YZ, Washie S, Warita K.  Preliminary study of the gene expression of sulfation and degradation enzymes for chondroitin sulfate in glycerol-treated C2C12 myoblast cells.  J Vet Med Sci  2022    PubMed ID: 35022360   DOI: 10.1292/jvms.21-0632

20555  Ikeno Y, Inomata M, Tsukimura Y, Suzuki Y, Takeuchi H, Harada Y, Kon R, Ikarashi N, Chiba Y, Yamada T, Kamei J, Sakai H.  Eicosapentaenoic acid suppresses cisplatin-induced muscle atrophy by attenuating the up-regulated gene expression of ubiquitin.  J Nutr Biochem  2022  108953  PubMed ID: 35121023   DOI: 10.1016/j.jnutbio.2022.108953

20574  Satoh F, Sugiura A, Tashiro J, Hosaka YZ, Warita K.  Chondroitin sulfate E downregulates N-cadherin and suppresses myotube formation.  J Vet Med Sci  2022    PubMed ID: 35173094   DOI: 10.1292/jvms.21-0662

16325  Mizutani S, Oyabu M, Yamamoto A, Uchitomi R, Sugimoto T, Kamei Y.  Vitamin D Activates Various Gene Expressions, Including Lipid Metabolism, in C2C12 Cells  J Nutr Sci Vitaminol (Tokyo)  2022  68(1):65-72  PubMed ID: 35228497   DOI: 10.3177/jnsv.68.65

16358  Oyabu M, Takigawa K, Mizutani S, Hatazawa Y, Fujita M, Ohira Y, Sugimoto T, Suzuki O, Tsuchiya K, Suganami T, Ogawa Y, Ishihara K, Miura S, Kamei Y.  FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting  FASEB J  2022  36(2):e22152  PubMed ID: 35061305   DOI: 10.1096/fj.202101385RR

16359  Ou Y, Jobu K, Ishida T, Morisawa S, Fujita H, Kawada K, Yoshioka S, Miyamura M.  Saikokeishikankyoto extract alleviates muscle atrophy in KKAy mice  J Nat Med  2022  76(2):379-388  PubMed ID: 34997408   DOI: 10.1007/s11418-021-01590-2

20669  Nakahata M, Tominaga N, Saito K, Nishiyama K, Tanino Y, Saiki K, Kojima M, Sakai S.  A bio-synthetic hybrid hydrogel formed under physiological conditions consisting of mucin and a synthetic polymer carrying boronic acid.  Macromol Biosci  2022  e2200055  PubMed ID: 35429097   DOI: 10.1002/mabi.202200055

20675  Fu X, Matsui T, Funaba M.  Enhancement of vitamin C-induced myogenesis by inhibition of extracellular signal-regulated kinase (ERK) 1/2 pathway.  Biochem Biophys Res Commun  2022  612:57-62  PubMed ID: 35504090   DOI: 10.1016/j.bbrc.2022.04.103

20709  Sawa R, Ohnishi A, Ohno M, Nagata M, Wake I, Okimura Y.  Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes.  Biochim Biophys Acta Gen Subj  2022  130174  PubMed ID: 35597502   DOI: 10.1016/j.bbagen.2022.130174

16636  Kazuya Furusawa, Ryo Teramae, Hirono Ohashi, Masahiro Shimizu  Development of Living “Bio-Robots” for Autonomous Actuations  Journal of Robotics and Mechatronics  2022  34:279-284    DOI: 10.20965/jrm.2022.p0279

20738  Yamamoto M, Miyata S.  Influences of Microscopic Imaging Conditions on Accuracy of Cell Morphology Discrimination Using Convolutional Neural Network of Deep Learning.  Micromachines (Basel)  2022  13(5)  PubMed ID: 35630227   DOI: 10.3390/mi13050760

16660  Matsumoto A, Tsuda H, Furui S, Kawada-Nagashima M, Anzai T, Seki M, Watanabe K, Muramatsu K, Osaka H, Iwamoto S, Nishino I, Yamagata T.  A case of congenital fiber-type disproportion syndrome presenting dilated cardiomyopathy with ACTA1 mutation  Mol Genet Genomic Med  2022  e2008  PubMed ID: 35757965   DOI: 10.1002/mgg3.2008

20742  Sakai H, Zhou Y, Miyauchi Y, Suzuki Y, Ikeno Y, Kon R, Ikarashi N, Chiba Y, Hosoe T, Kamei J.  Increased 20S Proteasome Expression and the Effect of Bortezomib during Cisplatin-Induced Muscle Atrophy.  Biol Pharm Bull  2022  45(7):910-918  PubMed ID: 35786599   DOI: 10.1248/bpb.b22-00177

20759  Jing Z, Okubo H, Morishige JI, Xu P, Hasan N, Nagata N, Ando H.  Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats.  Toxicol Lett  2022  366:17-25  PubMed ID: 35788046   DOI: 10.1016/j.toxlet.2022.06.012

16924  Mubarok W, Elvitigala KCML, Sakai S.  Tuning Myogenesis by Controlling Gelatin Hydrogel Properties through Hydrogen Peroxide-Mediated Cross-Linking and Degradation  Gels  2022  8(6):387  PubMed ID: 35735731   DOI: 10.3390/gels8060387

20818  Nakagawara K, Takeuchi C, Ishige K.  5'-CMP and 5'-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell line.  Biochem Biophys Rep  2022  31:101309  PubMed ID: 35865271   DOI: 10.1016/j.bbrep.2022.101309

17103  Haibo Qiao, Shoichiro Asayama  Guanidinopropyl end‐modified poly(ethylene glycol) to form highly compact plasmid DNA mono‐ion complexes by thermal treatment  Polymers for Advanced Technologies  2022  33:484-491    DOI: 10.1002/pat.5530

20832  Sakai H, Suzuki Y, Miyauchi Y, Sato F, Ando Y, Kon R, Ikarashi N, Chiba Y, Kamei J, Hosoe T.  Downregulation of Sparc-like protein 1 during cisplatin-induced inhibition of myogenic differentiation of C2C12 myoblasts.  Biochem Pharmacol  2022  204:115234  PubMed ID: 36041542   DOI: 10.1016/j.bcp.2022.115234

20904  Mu Q, Cui K, Wang ZJ, Matsuda T, Cui W, Kato H, Namiki S, Yamazaki T, Frauenlob M, Nonoyama T, Tsuda M, Tanaka S, Nakajima T, Gong JP.  Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions.  Nat Commun  2022  13(1):6213  PubMed ID: 36266283   DOI: 10.1038/s41467-022-34044-8

17314  Ota N, Tanaka N, Sato A, Shen Y, Yalikun Y, Tanaka Y.  Microenvironmental Analysis and Control for Local Cells under Confluent Conditions via a Capillary-Based Microfluidic Device  Anal Chem  2022  Nov 16  PubMed ID: 36383697   DOI: 10.1021/acs.analchem.2c02815

20981  Enoki Y, Nagai T, Hamamura Y, Osa S, Nakamura H, Taguchi K, Watanabe H, Maruyama T, Matsumoto K.  The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease.  J Cachexia Sarcopenia Muscle  2022    PubMed ID: 36562292   DOI: 10.1002/jcsm.13159

19489  Mori K, Sun H, Miura K, Simizu S.  Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts  Molecules  2021  26(18):5685  PubMed ID: 34577156   DOI: 10.3390/molecules26185685

13417  Fujita H, Mae K, Nagatani H, Horie M, Nagamori E.  Effect of hydrogen peroxide concentration on the maintenance and differentiation of cultured skeletal muscle cells.  J Biosci Bioeng  2021    PubMed ID: 33422389   DOI: 10.1016/j.jbiosc.2020.12.010

20029  Kono Y, Takegaki J, Ohba T, Matsuda K, Negoro R, Fujita S, Fujita T.  Magnetization of mesenchymal stem cells using magnetic liposomes enhances their retention and immunomodulatory efficacy in mouse inflamed skeletal muscle.  Int J Pharm  2021  596:120298  PubMed ID: 33529784   DOI: 10.1016/j.ijpharm.2021.120298

20095  Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H.  MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.  Commun Biol  2021  4(1):427  PubMed ID: 33782502   DOI: 10.1038/s42003-021-01952-2

14069  Inui T, Mei J, Imashiro C, Kurashina Y, Friend J, Takemura K.  Focused surface acoustic wave locally removes cells from culture surface  Lab Chip  2021  21(7):1299-1306  PubMed ID: 33734243   DOI: 10.1039/d0lc01293a

14070  Kondo T.  Selective eradication of pluripotent stem cells by inhibiting DHODH activity  Stem Cells  2021  39(1):33-42  PubMed ID: 33038285   DOI: 10.1002/stem.3290

14520  Sergio R. Molina Ramirez, Takahiro Yamada, Akira Funahashi, Hiroaki Onoe  Electrical Field Chamber with Dinamically Adaptable Stimuli for Myocyte Orientation During Cultivation  2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS)  2021      DOI: 10.1109/mems51782.2021.9375303

20215  Diao Z, Matsui T, Funaba M.  Stimulation of myogenesis by ascorbic acid and capsaicin.  Biochem Biophys Res Commun  2021  568:83-88  PubMed ID: 34198164   DOI: 10.1016/j.bbrc.2021.06.067

20236  Ueno M, Maeshige N, Hirayama Y, Yamaguchi A, Ma X, Uemura M, Kondo H, Fujino H.  Pulsed ultrasound prevents lipopolysaccharide-induced muscle atrophy through inhibiting p38 MAPK phosphorylation in C2C12 myotubes.  Biochem Biophys Res Commun  2021  570:184-190  PubMed ID: 34293592   DOI: 10.1016/j.bbrc.2021.07.039

20251  Fujita H, Horie M, Shimizu K, Nagamori E.  Microarray profiling of gene expression in C2C12 myotubes trained by electric pulse stimulation.  J Biosci Bioeng  2021    PubMed ID: 34348874   DOI: 10.1016/j.jbiosc.2021.06.016

20252  Oki K, Yoshihara S, Urushihata N, Ghazizadeh M.  Anti-fibrotic effect of adipose-derived mesenchymal stem cell conditioned medium in muscle fibrosis.  Eur Rev Med Pharmacol Sci  2021  25(15):4953-4963  PubMed ID: 34355367   DOI: 10.26355/eurrev_202108_26452

20273  Alfarafisa NM, Kitaguchi K, Yabe T.  Diospyros kaki extract protects myoblasts from oxidative stress-induced cytotoxicity via secretions derived from intestinal epithelium.  Biosci Biotechnol Biochem  2021  85(2):430-439  PubMed ID: 33604620   DOI: 10.1093/bbb/zbaa048

20301  Sawa R, Wake I, Yamamoto Y, Okimura Y.  The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.  Growth Horm IGF Res  2021  59:101406  PubMed ID: 34126555   DOI: 10.1016/j.ghir.2021.101406

20323  Mori D, Tsujikawa T, Sugiyama Y, Kotani SI, Fuse S, Ohmura G, Arai A, Kawaguchi T, Hirano S, Mazda O, Kishida T.  Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors.  Int J Cancer  2021    PubMed ID: 34460096   DOI: 10.1002/ijc.33786

20328  Obikane Y, Toyono T, Kokabu S, Matsuyama K, Kataoka S, Nakatomi M, Hosokawa R, Seta Y.  Myogenic differentiation 1 and transcription factor 12 activate the gene expression of mouse taste receptor type 1 member 1.  J Oral Biosci  2021    PubMed ID: 34492379   DOI: 10.1016/j.job.2021.08.005

20348  Kato H, Watanabe H, Imafuku T, Arimura N, Fujita I, Noguchi I, Tanaka S, Nakano T, Tokumaru K, Enoki Y, Maeda H, Hino S, Tanaka M, Matsushita K, Fukagawa M, Maruyama T.  Advanced oxidation protein products contribute to chronic kidney disease-induced muscle atrophy by inducing oxidative stress via CD36/NADPH oxidase pathway.  J Cachexia Sarcopenia Muscle  2021    PubMed ID: 34599649   DOI: 10.1002/jcsm.12786

20373  Okumura F, Oki N, Fujiki Y, Ikuta R, Osaki K, Hamada S, Nakatsukasa K, Hisamoto N, Hara T, Kamura T.  ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.  Sci Rep  2021  11(1):20880  PubMed ID: 34686700   DOI: 10.1038/s41598-021-00306-6

20375  Wang J, Zhang H, Kaul A, Li K, Priyandoko D, Kaul SC, Wadhwa R.  Effect of Ashwagandha Withanolides on Muscle Cell Differentiation.  Biomolecules  2021  11(10)  PubMed ID: 34680087   DOI: 10.3390/biom11101454

20425  Sakai H, Asami M, Naito H, Kitora S, Suzuki Y, Miyauchi Y, Tachinooka R, Yoshida S, Kon R, Ikarashi N, Chiba Y, Kamei J.  Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice.  J Cachexia Sarcopenia Muscle  2021    PubMed ID: 34268902   DOI: 10.1002/jcsm.12760

20464  Hoshiba T.  Decellularized Extracellular Matrix for Cell Biology.  Curr Protoc  2021  1(12):e318  PubMed ID: 34878719   DOI: 10.1002/cpz1.318

20488  Yanazawa K, Sugasawa T, Aoki K, Nakano T, Kawakami Y, Takekoshi K.  Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.  PeerJ  2021  9:e12285  PubMed ID: 34721976   DOI: 10.7717/peerj.12285

16360  Abdalkader R, Konishi S, Fujita T.  The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device  Biomimetics (Basel)  2021  7(1):2  PubMed ID: 35076457   DOI: 10.3390/biomimetics7010002

16363  Keiichi Imato, Hidekazu Nakajima, Ryota Yamanaka, Naoya Takeda  Self-healing polyurethane elastomers based on charge-transfer interactions for biomedical applications  Polymer Journal  2021  53:355-362    DOI: 10.1038/s41428-020-00432-4

16364  Iseki Y, Ono Y, Hibi C, Tanaka S, Takeshita S, Maejima Y, Kurokawa J, Murakawa M, Shimomura K, Sakamoto K.  Opening of Intermediate Conductance Ca 2+-Activated K + Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway  J Pharmacol Exp Ther  2021  376(3):454-462  PubMed ID: 33376149   DOI: 10.1124/jpet.120.000290

16792  Kennedy Omondi Okeyo, Yoshikiyo Kibe, Taiji Adachi  Controlling macroscale cell alignment in self-organized cell sheets by tuning the microstructure of adhesion-limiting micromesh scaffolds  Materials Today Advances  2021  12:100194    DOI: 10.1016/j.mtadv.2021.100194

16793  Hiromu Miyata, Zugui Peng, Kenta Shimba, Yoshitaka Miyamoto, Tohru Yagi  Development of novel ECM which has stiffness difference based on hydrogel beads  Electronics and Communications in Japan  2021  104    DOI: 10.1002/ecj.12321

16976  Yuji Kirihara, Hiromu Miyata, Zugui Peng, Kenta Shimba, Yoshitaka Miyamoto, Kazunori Shimizu, Hiroyuki Honda, Tohru Yagi  Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue  IEEJ Transactions on Electronics, Information and Systems  2021  141:795-801    DOI: 10.1541/ieejeiss.141.795

17039  Marcucci L, Fukunaga H, Yanagida T, Iwaki M.  The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism Beyond the Lever-Arm Swing  Int J Mol Sci  2021  22(13):7037  PubMed ID: 34210098   DOI: 10.3390/ijms22137037

19488  Sugasawa T, Tome Y, Takeuchi Y, Yoshida Y, Yahagi N, Sharma R, Aita Y, Ueda H, Maruyama R, Takeuchi K, Morita S, Kawamai Y, Takekoshi K.  Influence of Intermittent Cold Stimulations on CREB and Its Targeting Genes in Muscle: Investigations into Molecular Mechanisms of Local Cryotherapy  Int J Mol Sci  2020  21(13):4588  PubMed ID: 32605164   DOI: 10.3390/ijms21134588

6934  Baba K, Kuwada S, Nakao A, Li X, Okuda N, Nishida A, Mitsuda S, Fukuoka N, Kakeya H, Kataoka T.  Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.  Histochem Cell Biol  2020    PubMed ID: 31907597   DOI: 10.1007/s00418-019-01842-z

6964  Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T.  Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.  Bioorg Med Chem Lett  2020  30(4):126946  PubMed ID: 31928840   DOI: 10.1016/j.bmcl.2019.126946

9738  Kanano Kitamura, Jane Surya Erlangga, Sakuka Tsukamoto, Yuri Sakamoto, Hideaki Mabashi-Asazuma, Kaoruko Iida  Daidzein Promotes the Expression of Oxidative Phosphorylation- And Fatty Acid Oxidation-Related Genes via an Estrogen-Related Receptor α Pathway to Decrease Lipid Accumulation in Muscle Cells  J Nutr Biochem  2020  77:108315  PubMed ID: 31923756   DOI: 10.1016/j.jnutbio.2019.108315

12011  Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J.  TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice.  Sci Rep  2020    PubMed ID: 31959927   DOI: 10.1038/s41598-020-57714-3

12012  Hoshiba T, Yokoyama N.  Decellularized extracellular matrices derived from cultured cells at stepwise myogenic stages for the regulation of myotube formation.  Biochim Biophys Acta Mol Cell Res  2020    PubMed ID: 31978502   DOI: 10.1016/j.bbamcr.2020.118658

12069  Okada S, Fukai Y, Yoshimoto F, Saitoh H.  Chemical manipulations to facilitate membrane blebbing and vesicle shedding on the cellular cortex.  Biotechnol. Lett.  2020  42(7)  PubMed ID: 32112174   DOI: 10.1007/s10529-020-02848-7

12071  Imato K, Nagata K, Watanabe R, Takeda N.  Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds.  J Mater Chem B  2020    PubMed ID: 32108194   DOI: 10.1039/c9tb02958c

12078  Hidaka Y, Chiba-Ohkuma R, Karakida T, Onuma K, Yamamoto R, Fujii-Abe K, Saito MM, Yamakoshi Y, Kawahara H.  Combined Effect of Midazolam and Bone Morphogenetic Protein-2 for Differentiation Induction from C2C12 Myoblast Cells to Osteoblasts.  Pharmaceutics  2020    PubMed ID: 32131534   DOI: 10.3390/pharmaceutics12030218

12154  Kodai Kawaguchi, Yuto Fujita, Kenta Kato, and Arata Kaneko  Fabrication of Poly-Pyrrole Membrane Actuator for Cell Stimulation  IJAT  2020  14:167-174    DOI: 10.20965/ijat.2020.p0167

13008  Imai R, Horita S, Ono Y, Hagihara K, Shimizu M, Maejima Y, Shimomura K.  Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells.  Biores Open Access  2020    PubMed ID: 32368413   DOI: 10.1089/biores.2019.0034

13041  Wagatsuma A, Arakawa M, Matsumoto H, Matsuda R, Hoshino T, Mabuchi K.  Cobalt chloride, a chemical hypoxia-mimicking agent, suppresses myoblast differentiation by downregulating myogenin expression.  Mol Cell Biochem  2020    PubMed ID: 32451753   DOI: 10.1007/s11010-020-03762-2

13043  Inubushi T, Kosai A, Yanagisawa S, Chanbora C, Miyauchi M, Yamasaki S, Sugiyama E, Ishikado A, Makino T, Takata T.  Bovine lactoferrin enhances osteogenesis through Smad2/3 and p38 MAPK activation.  J Oral Biosci  2020    PubMed ID: 32464258   DOI: 10.1016/j.job.2020.05.001

13049  Lin M, Zhou S, Sakamoto K.  Alpha Mangostin promotes myogenic differentiation of C2C12 mouse myoblast cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32475640   DOI: 10.1016/j.bbrc.2020.04.128

13108  Imashiro C, Hirano M, Morikura T, Fukuma Y, Ohnuma K, Kurashina Y, Miyata S, Takemura K.  Detachment of cell sheets from clinically ubiquitous cell culture vessels by ultrasonic vibration.  Sci Rep  2020    PubMed ID: 32528073   DOI: 10.1038/s41598-020-66375-1

13127  Fukuma Y, Inui T, Imashiro C, Kurashina Y, Takemura K.  Homogenization of initial cell distribution by secondary flow of medium improves cell culture efficiency.  PLoS One  2020    PubMed ID: 32667933   DOI: 10.1371/journal.pone.0235827

13144  Sakai H, Ikeno Y, Tsukimura Y, Inomata M, Suzuki Y, Kon R, Ikarashi N, Chiba Y, Yamada T, Kamei J.  Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice.  Toxicol Appl Pharmacol  2020    PubMed ID: 32738330   DOI: 10.1016/j.taap.2020.115165

13159  Suzuki K, Matsumoto M, Katoh Y, Liu L, Ochiai K, Aizawa Y, Nagatomi R, Okuno H, Itoi E, Igarashi K.  Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation.  PLoS One  2020    PubMed ID: 32776961   DOI: 10.1371/journal.pone.0236781

13188  Takehara M, Kobayashi K, Nagahama M.  Clostridium perfringens α-toxin inhibits myogenic differentiation of C2C12 myoblasts.  Anaerobe  2020    PubMed ID: 32860931   DOI: 10.1016/j.anaerobe.2020.102265

13209  Nonaka K, Akiyama J, Yoshikawa Y, Une S, Ito K.  1,25-Dihydroxyvitamin D3 Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes.  Medicina (Kaunas)  2020    PubMed ID: 32899782   DOI: 10.3390/medicina56090450

13257  Shen Y, Yalikun Y, Aishan Y, Tanaka N, Sato A, Tanaka Y.  Area cooling enables thermal positioning and manipulation of single cells.  Lab Chip  2020    PubMed ID: 33000103   DOI: 10.1039/d0lc00523a

13259  Okano K, Wang CH, Hong ZY, Hosokawa Y, Liau I.  Selective induction of targeted cell death and elimination by near-infrared femtosecond laser ablation.  Biochem Biophys Rep  2020    PubMed ID: 33083577   DOI: 10.1016/j.bbrep.2020.100818

13319  Kono Y, Miyamoto A, Hiraoka S, Negoro R, Fujita T.  Mesenchymal Stem Cells Alter the Inflammatory Response of C2C12 Mouse Skeletal Muscle Cells.  Biol Pharm Bull  2020    PubMed ID: 33132324   DOI: 10.1248/bpb.b20-00536

13426  Shunsuke Kimura, EisukeKato  TAS2R expression profile in brown adipose, white adipose, skeletal muscle, small intestine, liver and common cell lines derived from mice  Gene Reports  2020      DOI: 10.1016/j.genrep.2020.100763

13562  Nakai S, Oyabu M, Hatazawa Y, Akashi S, Kitamura T, Miura S, Kamei Y.  FOXO1 suppresses PGC-1β gene expression in skeletal muscles  FEBS Open Bio  2020  10(7):1373-1388  PubMed ID: 32433820   DOI: 10.1002/2211-5463.12898

13592  Sekiya-Aoyama R, Arisaka Y, Yui N.  Mobility Tuning of Polyrotaxane Surfaces to Stimulate Myocyte Differentiation  Macromol Biosci  2020  20(4):e1900424  PubMed ID: 32058659   DOI: 10.1002/mabi.201900424

13766  Shen Y, Tanaka N, Yamazoe H, Furutani S, Nagai H, Kawai T, Tanaka Y.  Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin  PLoS One  2020  15(5):e0232518  PubMed ID: 32433673   DOI: 10.1371/journal.pone.0232518

19487  Yamamura K, Ashida H, Okano T, Kinoshita-Daitoku R, Suzuki S, Ohtani K, Hamagaki M, Ikeda T, Suzuki T.  Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene  Front Microbiol  2019  10:2406  PubMed ID: 31708887   DOI: 10.3389/fmicb.2019.02406

11183  Sakai H, Kimura M, Tsukimura Y, Yabe S, Isa Y, Kai Y, Sato F, Kon R, Ikarashi N, Narita M, Chiba Y, Kamei J.  Dexamethasone exacerbates cisplatin-induced muscle atrophy.  Clin. Exp. Pharmacol. Physiol.  2019  46(1):19-28  PubMed ID: 30137654   DOI: 10.1111/1440-1681.13024

11302  Baba TT, Terashima T, Oida S.  Liver-type of tissue non-specific alkaline phosphatase is induced during mouse bone and tooth cell differentiation.  Arch. Oral Biol.  2019    PubMed ID: 30439569   DOI: 10.1016/j.archoralbio.2018.10.036

11284  Hirai T, Nomura K, Ikai R, Nakashima KI, Inoue M.  Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes.  Biomed. Pharmacother.  2019    PubMed ID: 30399586   DOI: 10.1016/j.biopha.2018.10.154

11385  Obi S, Nakajima T, Hasegawa T, Nakamura F, Sakuma M, Toyoda S, Tei C, Inoue T.  Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).  FEBS Open Bio  2019    PubMed ID: 30652078   DOI: 10.1002/2211-5463.12550

11401  Ono S, Yoshida N, Maekawa D, Kitakaze T, Kobayashi Y, Kitano T, Fujita T, Okuwa-Hayashi H, Harada N, Nakano Y, Yamaji R.  5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy.  Food Sci Nutr  2019    PubMed ID: 30680186   DOI: 10.1002/fsn3.891

11327  Ishikawa K, Hara T, Kato K, Shimomura T, Omori K.  Involvement of natriuretic peptide system in C2C12 myocytes.  Mol. Cell. Biochem.  2019  56(1-2):15-27  PubMed ID: 30519782   DOI: 10.1007/s11010-018-3486-6

11340  Fang C, Cai X, Hayashi S, Hao S, Sakiyama H, Wang X, Yang Q, Akira S, Nishiguchi S, Fujiwara N, Tsutsui H, Sheng J.  Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 30553055   DOI: 10.1016/j.bbalip.2018.12.003

11452  Nakao M, Imashiro C, Kuribara T, Kurashina Y, Totani K, Takemura K.  Formation of Large Scaffold-Free 3-D Aggregates in a Cell Culture Dish by Ultrasound Standing Wave Trapping.  Ultrasound Med Biol  2019    PubMed ID: 30799124   DOI: 10.1016/j.ultrasmedbio.2019.01.013

11458  Adachi N, Kanazawa I, Tanaka KI, Takeno A, Notsu M, Tanaka S, Sugimoto T.  Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells.  Calcif. Tissue Int.  2019    PubMed ID: 30809689   DOI: 10.1007/s00223-019-00537-w

5803  Akiyama Y, Shinose M, Watanabe H, Yamada S, Kanda Y.  Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing.  Proc Natl Acad Sci U S A  2019  116(16):7738-7743  PubMed ID: 30936320   DOI: 10.1073/pnas.1808645116

7002  Fujita K, Ohmachi M, Ikezaki K, Yanagida T, Iwaki M.  Direct visualization of human myosin II force generation using DNA origami-based thick filaments.  Commun Biol  2019  2:437  PubMed ID: 31799438   DOI: 10.1038/s42003-019-0683-0

11602  Bansai S, Morikura T, Onoe H, Miyata S.  Effect of Cyclic Stretch on Tissue Maturation in Myoblast-Laden Hydrogel Fibers.  Micromachines (Basel)  2019    PubMed ID: 31208059   DOI: 10.3390/mi10060399

11657  Takehito Sugasawa, Tome Yoshiya, Yoshinori Takeuchi, Naoya Yahagi, Rahul Sharma, Yuichi Aita, Yasuko Yoshida, Katuyuki Tokinoya, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Reina Maruyama, Shohei Morita, Yasushi Kawamai, Kazuhiro Takekoshi  Influence of Intermittent Cold Stimulations on CREB and Its Targeting Genes in Muscle: Investigations into Molecular Mechanisms of Local Cryotherapy  molecular biology  2019      DOI: 10.20944/preprints201904.0277.v1

11658  Aruto Hori, Yuki Watabe, Masumi Yamada, Yuya Yajima, Rie Utoh, Minoru Seki  One-Step Formation of Microporous Hydrogel Sponges Encapsulating Living Cells by Utilizing Bicontinuous Dispersion of Aqueous Polymer Solutions  ACS Appl. Bio Mater.  2019    PubMed ID: 35030662   DOI: 10.1021/acsabm.9b00194

11663  Takumi Inui, Yuta Kurashina, Chikahiro Imashiro, Kenjiro Takemura  Method of localized removal of cells using a bolt‐clamped Langevin transducer with an ultrasonic horn  Eng Life Sci  2019  19:575–583  PubMed ID: 32625033   DOI: 10.1002/elsc.201800173

11692  Masahito Ban, Yuuya Kogi, Taichi Hirose  Fabrication of arrayed microwells with wrinkle microstructure by ink-jet and diamond-like carbon thin film deposition process  Materials Science and Engineering: B  2019      DOI: 10.1016/j.mseb.2019.114422

11711  Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato  cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells  Journal of Functional Foods  2019      DOI: 10.1016/j.jff.2019.103632

11723  Hashimoto M, Saito N, Ohta H, Yamamoto K, Tashiro A, Nakazawa K, Inanami O, Kitamura H.  Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts.  Physiol Rep  2019    PubMed ID: 31353872   DOI: 10.14814/phy2.14193

11749  Yamashita S, Matsuo Y, Tawara N, Hara K, Yamamoto M, Nishikami T, Kawakami K, Zhang X, Zhang Z, Doki T, Ando Y.  CYLD dysregulation in pathogenesis of sporadic inclusion body myositis.  Sci Rep  2019    PubMed ID: 31406156   DOI: 10.1038/s41598-019-48115-2

11856  Hamaya E, Fujisawa T, Tamura M.  Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells.  Int. J. Mol. Med.  2019    PubMed ID: 31638177   DOI: 10.3892/ijmm.2019.4376

11868  Kita S, Fukuda S, Maeda N, Shimomura I.  Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin.  Elife  2019    PubMed ID: 31647413   DOI: 10.7554/eLife.48675

11874  Terao Y, Kurashina Y, Tohyama S, Fukuma Y, Fukuda K, Fujita J, Takemura K.  An effective detachment system for human induced pluripotent stem cells cultured on multilayered cultivation substrates using resonance vibrations.  Sci Rep  2019    PubMed ID: 31666563   DOI: 10.1038/s41598-019-51944-w

10417  Katsuyuki Tokinoya and Kazuhiro Takekoshi  Effect of renalase on dexamethasone-induced muscle atrophy  Int J Anal Bio-Sci  2019  7(4):68-75

11899  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Engineered topographical structure to control spatial cell density using cell migration.  Biomed Microdevices  2019    PubMed ID: 31729612   DOI: 10.1007/s10544-019-0447-0

12133  Mihaela Pantea, Diana Andreea Ighigeanu, Alexandra Totan, Maria Greabu, Daniela Miricescu,marina Melescanu Imre, Cosmin Totan, Tudor Claudiu Spinu, Alexandru Petre, Angelica Bencze, Stefan Milicescu, Ana Maria Cristina Tancu  Interactions Between Dental Composite Resins and Saliva A comparative biochemical in vitro study  Materiale Plastice (Mater. Plast.)  2019      DOI: 10.37358/MP.19.3.5223

12396  Hirata Y, Toyono T, Kokabu S, Obikane Y, Kataoka S, Nakatomi M, Masaki C, Hosokawa R, Seta Y.  Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells  Biomed Res  2019  40(2):67-78  PubMed ID: 30982802   DOI: 10.2220/biomedres.40.67

12397  Ishikawa K, Yoshida K, Kanie K, Omori K, Kato R.  Morphology-Based Analysis of Myoblasts for Prediction of Myotube Formation  SLAS Discov  2019  24(1):47-56  PubMed ID: 30102873   DOI: 10.1177/2472555218793374

12398  Ishida T, Iizuka M, Ou Y, Morisawa S, Hirata A, Yagi Y, Jobu K, Morita Y, Miyamura M.  Juzentaihoto hot water extract alleviates muscle atrophy and improves motor function in streptozotocin-induced diabetic oxidative stress mice  J Nat Med  2019  73(1):202-209  PubMed ID: 30478793   DOI: 10.1007/s11418-018-1269-8

12399  Arifuzzaman M, Ito A, Ikeda K, Kawabe Y, Kamihira M.  Fabricating Muscle-Neuron Constructs with Improved Contractile Force Generation  Tissue Eng Part A  2019  25(7-8):563-574  PubMed ID: 30221587   DOI: 10.1089/ten.TEA.2018.0165

12400  Matsuda R, Uchitomi R, Oyabu M, Hatazawa Y, Kamei Y.  Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1  FEBS Lett  2019  593(12):1303-1312  PubMed ID: 31111473   DOI: 10.1002/1873-3468.13445

12401  Watamoto Y, Futawaka K, Hayashi M, Matsushita M, Mitsutani M, Song Z, Koyama R, Fukuda Y, Nushida A, Nezu S, Kuwahara A, Kataoka K, Tagami T, Moriyama K.  IGF-1 regulate the expression of uncoupling protein 2 via FOXO1  Growth Factors  2019  37(5-6):247-256  PubMed ID: 32156173   DOI: 10.1080/08977194.2020.1739032

12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389   DOI: 10.1371/journal.pone.0214000

14052  Imashiro C, Kurashina Y, Kuribara T, Hirano M, Totani K, Takemura K.  Cell Patterning Method on a Clinically Ubiquitous Culture Dish Using Acoustic Pressure Generated From Resonance Vibration of a Disk-Shaped Ultrasonic Transducer  IEEE Trans Biomed Eng  2019  66(1):111-118  PubMed ID: 29993416   DOI: 10.1109/TBME.2018.2835834

15193  Linke P, Suzuki R, Yamamoto A, Nakahata M, Kengaku M, Fujiwara T, Ohzono T, Tanaka M.  Dynamic Contact Guidance of Myoblasts by Feature Size and Reversible Switching of Substrate Topography: Orchestration of Cell Shape, Orientation, and Nematic Ordering of Actin Cytoskeletons  Langmuir  2019  35(23):7538-7551  PubMed ID: 30376342   DOI: 10.1021/acs.langmuir.8b02972

10657  Kawai S, Yamauchi M, Amano A.  Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation.  J. Bone Miner. Metab.  2018  36(6):640-647  PubMed ID: 29234951   DOI: 10.1007/s00774-017-0885-9

10659  Wagatsuma A, Takayama Y, Hoshino T, Shiozuka M, Yamada S, Matsuda R, Mabuchi K.  Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway.  Mol. Cell. Biochem.  2018  445(1-2):45-58  PubMed ID: 29248972   DOI: 10.1007/s11010-017-3250-3

10712  Hatazawa Y, Qian K, Gong DW, Kamei Y.  PGC-1α regulates alanine metabolism in muscle cells.  PLoS ONE  2018  13:e0190904  PubMed ID: 29315328   DOI: 10.1371/journal.pone.0190904

10731  Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH.  Cell type-specific suppression of mechanosensitive genes by audible sound stimulation.  PLoS ONE  2018  13:e0188764  PubMed ID: 29385174   DOI: 10.1371/journal.pone.0188764

10756  Kitakaze T, Oshimo M, Kobayashi Y, Ryu M, Suzuki YA, Inui H, Harada N, Yamaji R.  Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy.  Mol Med Rep  2018  17:5912-5920  PubMed ID: 29436684   DOI: 10.3892/mmr.2018.8603

10769  Mizuguchi Y, Yatabe M, Morishima N, Morimoto S, Ichihara A.  Buffering roles of (pro)renin receptor in starvation-induced autophagy of skeletal muscles.  Physiol Rep  2018  6:  PubMed ID: 29488348   DOI: 10.14814/phy2.13587

11134  Fujiki J, Maeda N, Sato M, Ieko T, Inoue H, Iwasaki T, Iwano H, Yokota H.  Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells.  Steroids  2018  138:64-71  PubMed ID: 30018003   DOI: 10.1016/j.steroids.2018.07.001

11094  Yamasaki M, Hamada K, Fujii K, Nishiyama K, Yamasaki Y, Tari H, Araki K, Arakawa T.  Vaccinium ashei leaves extract alleviates insulin resistance via AMPK independent pathway in C2C12 myotube model.  Biochem Biophys Rep  2018  14:182-187  PubMed ID: 29872751   DOI: 10.1016/j.bbrep.2018.05.003

11104  Yuasa K, Okubo K, Yoda M, Otsu K, Ishii Y, Nakamura M, Itoh Y, Horiuchi K.  Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy.  Sci Rep  2018  8(1):9037  PubMed ID: 29899565   DOI: 10.1038/s41598-018-26632-w

11127  Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, Nagayama K, Maki K, Yamamoto M, Kamijo R.  Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.  Sci Rep  2018  8(1):10579  PubMed ID: 30002387   DOI: 10.1038/s41598-018-28605-5

11181  Tawara N, Yamashita S, Kawakami K, Kurashige T, Zhang Z, Tasaki M, Yamamoto Y, Nishikami T, Doki T, Zhang X, Matsuo Y, Kimura E, Tawara A, Maeda Y, Hauschka SD, Maruyama H, Ando Y.  Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.  Exp. Neurol.  2018  309:169-180  PubMed ID: 30130494   DOI: 10.1016/j.expneurol.2018.08.006

11188  Ogiwara M, Ota W, Mizushige T, Kanamoto R, Ohinata K.  Enzymatic digest of whey protein and wheylin-1, a dipeptide released in the digest, increase insulin sensitivity in an Akt phosphorylation-dependent manner.  Food Funct  2018  9(9):4635-4641  PubMed ID: 30151525   DOI: 10.1039/c8fo00919h

11227  Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, Okimura Y.  Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.  Growth Horm. IGF Res.  2018    PubMed ID: 30273774   DOI: 10.1016/j.ghir.2018.09.002

11239  Yano H, Uchida M, Saito T, Aoki T, Kremenik MJ, Oyanagi E.  Reduction of Real-Time Imaging of M1 Macrophage Chemotaxis toward Damaged Muscle Cells is PI3K-Dependent.  Antioxidants (Basel)  2018    PubMed ID: 30297636   DOI: 10.3390/antiox7100138

11285  Ohashi M, Okubo K, Mizuno S, Yoda M, Shirasawa H, Chiba K, Horiuchi K, Matsumoto M, Nakamura M.  Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30401566   DOI: 10.1016/j.bbrc.2018.10.196

11314  Tsukamoto S, Shibasaki A, Naka A, Saito H, Iida K.  Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo.  Int J Mol Sci  2018    PubMed ID: 30463265   DOI: 10.3390/ijms19113649

4077  Masahito Ban, Satoshi Tobea, Louie Takeuchi  Effects of diamond-like carbon thin film and wrinkle microstructure on cell proliferation  Diamond and Related Materials  2018  90:194-201    DOI: 10.1016/j.diamond.2018.10.021

4167  Asano T, Igarashi H, Ishizuka T, Yawo H.  Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.  Front Neurosci  2018    PubMed ID: 30174581   DOI: 10.3389/fnins.2018.00561

4168  Hanafy AK, Shinaishin SF, Eldeen GN, Aly RM.  Nano Hydroxyapatite & Mineral Trioxide Aggregate Efficiently Promote Odontogenic Differentiation of Dental Pulp Stem Cells.  Open Access Maced J Med Sci  2018    PubMed ID: 30337999   DOI: 10.3889/oamjms.2018.368

4169  Kameyama T, Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Seki J, Kawase C, Tsuruma K, Nishino I, Nakamura S, Shimazawa M, Saito T, Takeda S, Kaneko H, Hara H.  Efficacy of Prednisolone in Generated Myotubes Derived From Fibroblasts of Duchenne Muscular Dystrophy Patients.  Front Pharmacol  2018    PubMed ID: 30559667   DOI: 10.3389/fphar.2018.01402

4170  Nakao M, Kurashina Y, Imashiro C, Takemura K.  A Method for Collecting Single Cell Suspensions Using an Ultrasonic Pump.  IEEE Trans Biomed Eng  2018    PubMed ID: 28463184   DOI: 10.1109/TBME.2017.2699291

4171  Miyakawa S, Uesugi K, Morishima K.  A Closed System for Pico-Liter Order Substance Transport from a Giant Liposome to a Cell.  Micromachines (Basel)  2018    PubMed ID: 30424264   DOI: 10.3390/mi9070331

14553  Valentine WJ, Tokuoka SM, Hishikawa D, Kita Y, Shindou H, Shimizu T.  LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation  J Lipid Res  2018  59(2):184-194  PubMed ID: 29284664   DOI: 10.1194/jlr.M077321

14902  Kanayama S, Kaito T, Kitaguchi K, Ishiguro H, Hashimoto K, Chijimatsu R, Otsuru S, Takenaka S, Makino T, Sakai Y, Myoui A, Yoshikawa H.  ONO-1301 Enhances in vitro Osteoblast Differentiation and in vivo Bone Formation Induced by Bone Morphogenetic Protein  Spine (Phila Pa 1976)   2018  43(11):E616-E624  PubMed ID: 29016438   DOI: 10.1097/BRS.0000000000002439

9859  Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, Kokubu T, Kurosaka M.  Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations.  J. Orthop. Res.  2017  35:1806-1815  PubMed ID: 27684960   DOI: 10.1002/jor.23451

9910  Arai S, Ikeda M, Ide T, Matsuo Y, Fujino T, Hirano K, Sunagawa K, Tsutsui H.  Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation.  Am. J. Physiol., Cell Physiol.  2017  312:C29-C39  PubMed ID: 27806939   DOI: 10.1152/ajpcell.00090.2016

10095  Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H.  Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.  Biochem Biophys Rep  2017  9:322-329  PubMed ID: 28956020   DOI: 10.1016/j.bbrep.2017.01.009

10179  Ono A, Ito A, Sato T, Yamaguchi M, Suzuki T, Kawabe Y, Kamihira M.  Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain.  J. Biosci. Bioeng.  2017  124:115-124  PubMed ID: 28284789   DOI: 10.1016/j.jbiosc.2017.02.012

10180  Go S, Go S, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.  Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.  J. Biol. Chem.  2017  292:7040-7051  PubMed ID: 28275055   DOI: 10.1074/jbc.M116.771253

10348  Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku T, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T.  Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.  J Cachexia Sarcopenia Muscle  2017  8:735-747  PubMed ID: 28608457   DOI: 10.1002/jcsm.12202

10375  Kurashina Y, Hirano M, Imashiro C, Totani K, Komotori J, Takemura K.  Enzyme-free cell detachment mediated by resonance vibration with temperature modulation.  Biotechnol. Bioeng.  2017  114:2279-2288  PubMed ID: 28627736   DOI: 10.1002/bit.26361

10413  Yoshida K, Imamura CK, Hara K, Mochizuki M, Tanigawara Y.  Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12).  Metabolomics  2017  13:98  PubMed ID: 28781589   DOI: 10.1007/s11306-017-1236-5

10442  Ono Y, Sakamoto K.  Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α.  PLoS ONE  2017  12:e0182040  PubMed ID: 28742154   DOI: 10.1371/journal.pone.0182040

10462  Ogawa M, Kitano T, Kawata N, Sugihira T, Kitakaze T, Harada N, Yamaji R.  Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice.  J. Nutr. Biochem.  2017  49:63-70  PubMed ID: 28886438   DOI: 10.1016/j.jnutbio.2017.07.017

10476  Minami K, Mori T, Nakanishi W, Shigi N, Nakanishi J, Hill JP, Komiyama M, Ariga K.  Suppression of Myogenic Differentiation of Mammalian Cells Caused by Fluidity of a Liquid-Liquid Interface.  ACS Appl Mater Interfaces  2017  9:30553-30560  PubMed ID: 28836758   DOI: 10.1021/acsami.7b11445

10477  Asano T, Ishizuka T, Yawo H.  Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.  Methods Mol. Biol.  2017  1668:135-145  PubMed ID: 28842907   DOI: 10.1007/978-1-4939-7283-8_10

10479  Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y.  Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells.  Nutr Res  2017  47:13-20  PubMed ID: 29241574   DOI: 10.1016/j.nutres.2017.08.003

10511  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190   DOI: 10.1109/EMBC.2017.8037146

10536  Fujiwara Y, Tsukahara C, Ikeda N, Sone Y, Ishikawa T, Ichi I, Koike T, Aoki Y.  Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4.  J Clin Biochem Nutr  2017  61:196-202  PubMed ID: 29203961   DOI: 10.3164/jcbn.16-120

10942  Takayuki Hoshino ; Moto Yoshioka ; Akira Wagatsuma ; Hiroki Miyazako ; Kunihiko Mabuchi  Fine virtual cathode display for biomolecules control and cell nano surgery  IEEE Xplore  2017      DOI: 10.1109/MEMSYS.2017.7863471

10943    On-chip internalization process of an intracellular nanobot into a single cell  IEEE Xplore  2017      DOI: 10.1109/MEMSYS.2017.7863473

10963    Cell descent caused by boundary curvature of a high topographical structure for a device that changes cell density  Japanese Journal of Applied Physics  2017  56:06GM03    DOI: 10.7567/JJAP.56.06GM03

12216  Hideo Saito, Koshi N Kishimoto, Yu Mori, Hiroshi Okuno, Masahiko Tanaka, Eiji Itoi  A vitamin D analogue, eldecalcitol, enhances expression of fast myosin heavy chain subtypes in differentiated C2C12 myoblasts  J Orthop Sci  2017  22(2):345-350  PubMed ID: 28017710   DOI: 10.1016/j.jos.2016.12.005

14209  Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions  Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions  Sci Rep  2017  7(1):7660  PubMed ID: 28794475   DOI: 10.1038/s41598-017-07934-x

14370  Tanaka S, Ono Y, Sakamoto K.  DCEBIO facilitates myogenic differentiation via intermediate conductance Ca 2+ activated K + channel activation in C2C12 myoblasts  J Pharmacol Sci  2017  133(4):276-279  PubMed ID: 28302447   DOI: 10.1016/j.jphs.2017.02.005

14492  Ikeda K, Ito A, Sato M, Kanno S, Kawabe Y, Kamihira M.  Effects of heat stimulation and l-ascorbic acid 2-phosphate supplementation on myogenic differentiation of artificial skeletal muscle tissue constructs  J Tissue Eng Regen Med  2017  11(5):1322-1331  PubMed ID: 26033935   DOI: 10.1002/term.2030

14634  Yuto Nishidono, Takashi Fujita, Akira Kawanami, Mikio Nishizawa, Ken Tanaka  Identification of PGC-1α activating constituents in Zingiberaceous crude drugs  Fitoterapia  2017  122:40-44  PubMed ID: 28827002   DOI: 10.1016/j.fitote.2017.08.007

14640  Fujii C, Miyashita K, Mitsuishi M, Sato M, Fujii K, Inoue H, Hagiwara A, Endo S, Uto A, Ryuzaki M, Nakajima M, Tanaka T, Tamaki M, Muraki A, Kawai T, Itoh H.  Treatment of sarcopenia and glucose intolerance through mitochondri  Sci Rep  2017  7(1):4013  PubMed ID: 28638045   DOI: 10.1038/s41598-017-03917-0

14764  Yasuko Yoshida, Takehito Sugasawa, Katsuyuki Tokinoya, Shunji Namba, Kazuhiro Takekoshi  Epinephrine upregulates renalase expression in cultured C2C12 muscle cells  Int J Anal Bio-Sci  2017  5:61-65

7146  Toda K, Takeda S, Hitoe S, Nakamura S, Matsuda H, Shimoda H.  Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism.  J Nat Med  2016  70:163-72  PubMed ID: 26581843   DOI: 10.1007/s11418-015-0948-y

7184  Nozaki T, Nikai S, Okabe R, Nagahama K, Eto N.  A novel in vitro model of sarcopenia using BubR1 hypomorphic C2C12 myoblasts.  Cytotechnology  2016  68:1705-15  PubMed ID: 26464273   DOI: 10.1007/s10616-015-9920-7

9797  Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T.  Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.  Sci Rep  2016  6:32084  PubMed ID: 27549031   DOI: 10.1038/srep32084

9803  Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, Yamaji R.  The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.  Biochem. Biophys. Res. Commun.  2016  478:1292-7  PubMed ID: 27553280   DOI: 10.1016/j.bbrc.2016.08.114

10874    Electron beam induced fine virtual electrode for mechanical strain microscopy of living cell  Sensors and Actuators B: Chemical   2016  236, 659-667    DOI: 10.1016/j.snb.2016.06.023

10886    Improvement of Mitochondrial Function and Lipid Utilization by 3,5-dihydroxy-4-methoxybenzyl Alcohol, an Oyster-derived polyphenol, in Oleate-loaded C2C12 Myotubes  Journal of Food and Nutrition Research  2016  4, 498    DOI: 10.12691/jfnr-4-8-3

12906  Shiozaki K, Harasaki Y, Fukuda M, Yoshinaga A, Ryuzono S, Chigwechokha PK, Komatsu M, Miyagi T.  Positive regulation of myoblast differentiation by medaka Neu3b sialidase through gangliosides desialylation  Biochimie  2016  123:65-72  PubMed ID: 26805383   DOI: 10.1016/j.biochi.2016.01.010

12926  Ikeda K, Ito A, Sato M, Kawabe Y, Kamihira M.  Improved contractile force generation of tissue-engineered skeletal muscle constructs by IGF-I and Bcl-2 gene transfer with electrical pulse stimulation  Regen Ther  2016  3:38-44  PubMed ID: 31245471   DOI: 10.1016/j.reth.2015.12.004

12932  Hu X, Cheng D, Zhang Z.  Antidiabetic activity of Helicteres angustifolia root  Pharm Biol  2016  54(6):938-44  PubMed ID: 26866383   DOI: 10.3109/13880209.2015.1077871

12944  Futawaka K, Tagami T, Fukuda Y, Koyama R, Nushida A, Nezu S, Imamoto M, Kasahara M, Moriyama K.  Growth hormone regulates the expression of UCP2 in myocytes  Growth Horm IGF Res  2016  29:57-62  PubMed ID: 27150070   DOI: 10.1016/j.ghir.2016.04.005

12750  Nakatani M, Ito J, Koyama R, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD.  Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2  Biochem Biophys Res Commun  2016  474(2):413-420  PubMed ID: 27114303   DOI: 10.1016/j.bbrc.2016.04.119

13457  Hu XS, Cheng DL, Li KJ, Wang LB, Yang X, Sun S, Wang YP, Li SH, Lei ZF, Zhang ZY.  Glucose consumption and alpha-glucosidase inhibitory activities of aqueous root extract of Helicteres angustifolia  Eur Rev Med Pharmacol Sci  2016  20(7):1423-9.  PubMed ID: 27097967

13966  Sato H, Funaki A, Kimura Y, Sumitomo M, Yoshida H, Fukata H, Ueno K.  Ethanol extract of Cyclolepis genistoides D. Don (palo azul) induces formation of myotubes, which involves differentiation of C2C12 myoblast cells  Nutr Res  2016  36(7):731-41  PubMed ID: 27262535   DOI: 10.1016/j.nutres.2016.02.011

14042  Shirai M, Yamamoto R, Chiba T, Komatsu K, Shimoda S, Yamakoshi Y, Oida S, Ohkubo C.  Bone augmentation around a dental implant using demineralized bone sheet containing biologically active substances  Dent Mater J  2016  35(3):470-8  PubMed ID: 27252004   DOI: 10.4012/dmj.2016-026

14096  Takeda N, Tamura K, Mineguchi R, Ishikawa Y, Haraguchi Y, Shimizu T, Hara Y.  In situ cross-linked electrospun fiber scaffold of collagen for fabricating cell-dense muscle tissue  J Artif Organs  2016  19(2):141-8  PubMed ID: 26472433   DOI: 10.1007/s10047-015-0871-8

14102  Warita K, Oshima N, Takeda-Okuda N, Tamura JI, Hosaka YZ.  Degree of Suppression of Mouse Myoblast Cell Line C₂C 12 Differentiation Varies According to Chondroitin Sulfate Subtype  Mar Drugs  2016  14(10):193  PubMed ID: 27775651   DOI: 10.3390/md14100193

14115  Onishi Y, Fukasawa K, Ozaki K, Iezaki T, Yoneda Y, Hinoi E.  GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice  Biochem Biophys Rep  2016  5: 216–223.  PubMed ID: 28955827   DOI: 10.1016/j.bbrep.2015.12.008

15304  Tanahashi H, Tian QB, Hara Y, Sakagami H, Endo S, Suzuki T.  Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance  Sci Rep  2016  6:20241  PubMed ID: 26847765   DOI: 10.1038/srep20241

7142  Washio K, Kobayashi M, Saito N, Amagasa M, Kitamura H.  Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts.  Evid Based Complement Alternat Med  2015  2015:349751  PubMed ID: 26604971   DOI: 10.1155/2015/349751

7250  Otani M, Furukawa S, Wakisaka S, Maeda T.  A novel adipokine C1q/TNF-related protein 3 is expressed in developing skeletal muscle and controls myoblast proliferation and differentiation.  Mol. Cell. Biochem.  2015  409:271-82  PubMed ID: 26272338   DOI: 10.1007/s11010-015-2531-y

7284  Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K.  A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice.  Food Funct  2015  6:2749-57  PubMed ID: 26152190   DOI: 10.1039/c5fo00401b

7311  Ichimura T, Chiu LD, Fujita K, Machiyama H, Kawata S, Watanabe TM, Fujita H.  Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging.  Sci Rep  2015  5:11358  PubMed ID: 26079396   DOI: 10.1038/srep11358

7323  Minami K, Kasuya Y, Yamazaki T, Ji Q, Nakanishi W, Hill JP, Sakai H, Ariga K.  Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering.  Adv. Mater. Weinheim  2015  27:4020-6  PubMed ID: 26033774   DOI: 10.1002/adma.201501690

7416  Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V.  Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.  Curr Gene Ther  2015  15:313-25  PubMed ID: 25832622   DOI: 10.2174/156652321503150329003735

7454  Takeda I, Kawanabe M, Kaneko A.  Autonomous patterning of cells on microstructured fine particles.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259   DOI: 10.1016/j.msec.2015.02.010

7465  Takemoto K, Ishihara S, Mizutani T, Kawabata K, Haga H.  Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.  PLoS ONE  2015  10:e0117937  PubMed ID: 25734240   DOI: 10.1371/journal.pone.0117937

7472  Takeda T, Tsuiji K, Li B, Tadakawa M, Yaegashi N.  Proliferative effect of Hachimijiogan, a Japanese herbal medicine, in C2C12 skeletal muscle cells.  Clin Interv Aging  2015  10:445-51  PubMed ID: 25709418   DOI: 10.2147/CIA.S75945

7483  Nakanishi K, Kakiguchi K, Yonemura S, Nakano A, Morishima N.  Transient Ca2+ depletion from the endoplasmic reticulum is critical for skeletal myoblast differentiation.  FASEB J.  2015  29:2137-49  PubMed ID: 25678623   DOI: 10.1096/fj.14-261529

7488  Asano T, Ishizuka T, Morishima K, Yawo H.  Optogenetic induction of contractile ability in immature C2C12 myotubes.  Sci Rep  2015  5:8317  PubMed ID: 25661648   DOI: 10.1038/srep08317

7509  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.  Hyaluronan inhibits BMP-induced osteoblast differentiation.  FEBS Lett.  2015  589:447-54  PubMed ID: 25592835   DOI: 10.1016/j.febslet.2014.12.031

7576  Yuki Igaki, Fumio Mizutani, Tomoyuki Yasukawa  Oxygen consumption of contractile C2C12 myotubes investigated by scanning electrochemical microscopy.  Chemistry Letters  2015  44:1031-1032    DOI: 10.1246/cl.150371

5450  Sugita S1, Hosaka Y2, Okada K1, Mori D3, Yano F4, Kobayashi H1, Taniguchi Y1, Mori Y1, Okuma T1, Chang SH1, Kawata M1, Taketomi S1, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T.  Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.  Proc Natl Acad Sci U S A  2015  112(10):3080-5  PubMed ID: 25733872   DOI: 10.1073/pnas.1419699112

9392  Masahiko Terauchi, Go Ikeda, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada, Nobuhiko Yui  Supramolecular Polyelectrolyte Complexes of Bone Morphogenetic Protein-2 With Sulfonated Polyrotaxanes to Induce Enhanced Osteogenic Differentiation  Macromol Biosci  2015  15(7):953-64  PubMed ID: 25810046   DOI: 10.1002/mabi.201500032

14137  小川真弘、河田夏初、山地亮一  速筋における大豆イソフラボンによるインスリン様成長因子の発現調節機構に関する研究  大豆たん白質研究  2015  18

14989  Horie M, Warabi E, Komine S, Oh S, Shoda J.  Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube  PLoS One  2015  10(12):e0144835  PubMed ID: 26658309   DOI: 10.1371/journal.pone.0144835

15022  Ogawa M, Kitakaze T, Harada N, Yamaji R.  Female-specific regulation of skeletal muscle mass by USP19 in young mice  J Endocrinol  2015  225(3):135-45  PubMed ID: 25901042   DOI: 10.1530/JOE-15-0128

15062  Park E, Cho HB, Takimoto K.  Effective gene delivery into adipose-derived stem cells: transfection of cells in suspension with the use of a nuclear localization signal peptide-conjugated polyethylenimine  Cytotherapy  2015  17(5):536-42  PubMed ID: 25618562   DOI: 10.1016/j.jcyt.2014.11.008

10473  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.  The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy  PLoS One  2015  10(7):e0133713  PubMed ID: 26226340   DOI: 10.1371/journal.pone.0133713

15432  Yoshino M, Naka A, Sakamoto Y, Shibasaki A, Toh M, Tsukamoto S, Kondo K, Iida K.  Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells  J Nutr Biochem  2015  26(11):1193-9  PubMed ID: 26166229   DOI: 10.1016/j.jnutbio.2015.05.010

15447  Tamaki M, Hagiwara A, Miyashita K, Wakino S, Inoue H, Fujii K, Fujii C, Sato M, Mitsuishi M, Muraki A, Hayashi K, Doi T, Itoh H.  Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice  Endocrinology  2015  156(10):3638-48  PubMed ID: 26241123   DOI: 10.1210/en.2015-1353

6677  Katase N, Terada K, Suzuki T, Nishimatsu S, Nohno T.  miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells  BMC Cell Biol  2015  16:13  PubMed ID: 25925429   DOI: 10.1186/s12860-015-0061-9

5402  Takara Tanaka, Noriko Hattori-Aramaki, Ayano Sunohara, Keisuke Okabe, Yoshiaki Sakamoto, Hiroko Ochiai, Ruka Hayashi, and Kazuo Kishi  Alignment of Skeletal Muscle Cells Cultured in Collagen Gel by Mechanical and Electrical Stimulation  International Journal of Tissue Engineering  2014  Article ID 621529, 5 pages    DOI: 10.1155/2014/621529

13947  Saito M, Karakida T, Yamamoto R, Nagano T, Yamakoshi Y, Hayakawa T, Oida S, Gomi K.  Differentiation potential of osteoblast from cultured C2C12 cells on zirconia disk  Dent Mater J  2014  33(2):275-83  PubMed ID: 24682023   DOI: 10.4012/dmj.2013-321

15322  Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.  Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene  J Nat Prod  2014  77(7):1670-7  PubMed ID: 24959987   DOI: 10.1021/np5002016

15905  Maeda A, Kai K, Ishii M, Ishii T, Akagawa M.  Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice  Mol Nutr Food Res  2014  58(6):1177-89  PubMed ID: 24668740   DOI: 10.1002/mnfr.201300675

15906  Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M.  Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells  Am J Physiol Endocrinol Metab  2014  306(9):E1065-76.  PubMed ID: 24619881   DOI: 10.1152/ajpendo.00597.2012

19168  Sakurako Matsumoto, Makoto Hayashi, Natsuko Tanabe, Yusuke Suzuki, Yoshimi Kobayashi, Hiroshi Kobayashi, Naoto Suzuki, Masao Maeno, Bunnai Ogiso  Calcium Ions Released from Mineral Trioxide Aggregate are Taken Up by C2C12 Cells via the L-Type Voltage-Dependent Calcium Channel  Journal of Hard Tissue Biology  2013  22:13-18    DOI: 10.2485/jhtb.22.13

19405  Mitsuishi M, Miyashita K, Muraki A, Tamaki M, Tanaka K, Itoh H.  Dietary protein decreases exercise endurance through rapamycin-sensitive suppression of muscle mitochondria  Am J Physiol Endocrinol Metab  2013  305(7):E776-84  PubMed ID: 23880314   DOI: 10.1152/ajpendo.00145.2013

9268  M Onishi, Y Fujita, H Yoshikawa, T Yamashita  Inhibition of Rac1 Promotes BMP-2-induced Osteoblastic Differentiation  Cell Death Dis  2013  4(6):e698  PubMed ID: 23807227   DOI: 10.1038/cddis.2013.226

12247  Riadh Drira, Kazuichi Sakamoto  Modulation of adipogenesis, lipolysis and glucose consumption in 3T3-L1 adipocytes and C2C12 myotubes by hydroxytyrosol acetate: a comparative study  Biochem Biophys Res Commun  2013  440(4):576-81  PubMed ID: 24099771   DOI: 10.1016/j.bbrc.2013.09.106

15937  Ito-Nagahata T, Kurihara C, Hasebe M, Ishii A, Yamashita K, Iwabuchi M, Sonoda M, Fukuhara K, Sawada R, Matsuoka A, Fujiwara Y.  Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK  Biosci Biotechnol Biochem  2013  1229-35  PubMed ID: 23748787   DOI: 10.1271/bbb.121000

19185  Takada M, Sumi M, Maeda A, Watanabe F, Kamiya T, Ishii T, Nakano M, Akagawa M.  Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice  Biochem Biophys Res Commun  2012  428(2):315-20  PubMed ID: 23085227   DOI: 10.1016/j.bbrc.2012.10.055

3649  Asano T, Ishizua T, Yawo H.  Optically controlled contraction of photosensitive skeletal muscle cells.  Biotechnol Bioeng  2012  109(1):199-204  PubMed ID: 21809334   DOI: 10.1002/bit.23285

13959  Mikami T, Koyama S, Yabuta Y, Kitagawa H.  Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies  J Biol Chem  2012  287(46):38531-42  PubMed ID: 23007393   DOI: 10.1074/jbc.M111.336925

13960  Suzuki D, Yamada A, Aizawa R, Funato S, Matsumoto T, Suzuki W, Takami M, Miyamoto Y, Suzawa T, Yamamoto M, Baba K, Kamijo R.  BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation  Calcif Tissue Int  2012  91(1):88-96.  PubMed ID: 22644325   DOI: 10.1007/s00223-012-9614-5

15732  Okuno H, Kishimoto KN, Hatori M, Itoi E.  1α,25-dihydroxyvitamin D₃ enhances fast-myosin heavy chain expression in differentiated C2C12 myoblasts  Cell Biol Int   2012  36(5):441-7  PubMed ID: 22276695   DOI: 10.1042/CBI20100782

15763  Tadahiro Sunagawa, Kenji Watanabe, Yusuke Ozawa, Shohei Nakashima, Tomomasa Kanda, Motoyuki Tagashira, Manabu Sami, Takao Kaneko, Shoichi Tahara, Haruaki Nakaya, Takuji Shirasawa, Takahiko Shimizu  Apple Polyphenols Regulate Mitochondrial Superoxide Generation and Extend Survival in a Mouse Model of Dilated Cardiomyopathy  International Journal of Life Science and Medical Research  2012  2:46-51    DOI: 10.5963/lsmr0203003

15969  Hidetaka Uno, Zhi-hong Wang, Noriko Takada, Toru Ishizuka, Hiromu Yawo, Tsuneo Urisu  Channelrhodopsin as a Noble Biomaterial Useful for the Operation and Performance Test of the Ionchannel Devices  MATERIALS TRANSACTIONS  2012  53:1305-1309    DOI: 10.2320/matertrans.n-m2012814

16013  Yoshitake Akiyama, Takayuki Hoshino, Masayuki Hashimoto, Keisuke Morishima  Evaluation of mechanical stimulation effect on cellular orientation under confluence based on 2D-FFT and principal component analysis  Journal of Micro-Nano Mechatronics  2012  7:69-77    DOI: 10.1007/s12213-012-0045-1

16014  Kenji Takemoto, Takeomi Mizutani, Kazushi Tamura, Kazuki Takeda, Hisashi Haga, Kazushige Kawabata  The Number of Cyclic Stretch Regulates Cellular Elasticity in C2C12 Myoblasts  CellBio  2012  01:1-10    DOI: 10.4236/cellbio.2012.11001

7663  Ogawa M, Yamaji R, Higashimura Y, Harada N, Ashida H, Nakano Y, Inui H.  17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.  J. Biol. Chem.  2011  286:41455-65  PubMed ID: 21971047   DOI: 10.1074/jbc.M111.276824

7665  Tanaka S, Terada K, Nohno T.  Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells.  J Mol Signal  2011  6:12  PubMed ID: 21970630   DOI: 10.1186/1750-2187-6-12

7705  Suzuki Y, Koshi K, Imai K, Takahashi T, Kizaki K, Hashizume K.  Bone morphogenetic protein 4 accelerates the establishment of bovine trophoblastic cell lines.  Reproduction  2011  142:733-43  PubMed ID: 21862694   DOI: 10.1530/REP-11-0275

7712  Morishima N, Nakanishi K, Nakano A.  Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.  J. Biol. Chem.  2011  286:35227-35  PubMed ID: 21841196   DOI: 10.1074/jbc.M111.233502

7769  Tamura K, Mizutani T, Haga H, Kawabata K.  Active fluctuation in the cortical cytoskeleton observed by high-speed live-cell scanning probe microscopy.  Acta Biomater  2011  7:3766-72  PubMed ID: 21704197   DOI: 10.1016/j.actbio.2011.06.013

7857  Akiyama K, Tone J, Okabe M, Nishimoto S, Sugahara T, Kakinuma Y.  Inhibition of myotube formation by paraquat in the myoblast cell line C2C12.  J Toxicol Sci  2011  36:243-6  PubMed ID: 21467752   DOI: 10.2131/jts.36.243

7868  Zang L, Nishikawa M, Machida K, Ando M, Takahashi Y, Watanabe Y, Takakura Y.  Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy.  Gene Ther.  2011  18:891-7  PubMed ID: 21451577   DOI: 10.1038/gt.2011.35

7982  Itoigawa Y, Kishimoto KN, Sano H, Kaneko K, Itoi E.  Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture.  J. Orthop. Res.  2011  29:861-6  PubMed ID: 21246616   DOI: 10.1002/jor.21317

8078  Fujita H, Van Dau T, Shimizu K, Hatsuda R, Sugiyama S, Nagamori E.  Designing of a Si-MEMS device with an integrated skeletal muscle cell-based bio-actuator.  Biomed Microdevices  2011  13:123-9  PubMed ID: 20957437   DOI: 10.1007/s10544-010-9477-3

8092  Miyake M, Hayashi S, Iwasaki S, Uchida T, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells.  J. Cell. Physiol.  2011  226:1128-36  PubMed ID: 20945337   DOI: 10.1002/jcp.22434

8553  Neil A Mabbott, J Kenneth Baillie, Atsushi Kobayashi, David S Donaldson, Hitoshi Ohmori, Sun-Ok Yoon, Arnold S Freedman, Tom C Freeman, Kim M Summers  Expression of Mesenchyme-Specific Gene Signatures by Follicular Dendritic Cells: Insights From the Meta-Analysis of Microarray Data From Multiple Mouse Cell Populations  Immunology   2011  133(4):482-98  PubMed ID: 21635249   DOI: 10.1111/j.1365-2567.2011.03461.x

16308  Tavana H, Mosadegh B, Zamankhan P, Grotberg JB, Takayama S.  Microprinted feeder cells guide embryonic stem cell fate  Biotechnol Bioeng  2011  108(10):2509-16  PubMed ID: 21538333   DOI: 10.1002/bit.23190

18157  Tamura K, Mizutani T, Haga H, Kawabata K.  Nano-mechanical properties of living cells expressing constitutively active RhoA effectors  Biochem Biophys Res Commun  2010  403(3-4):363-7  PubMed ID: 21078298   DOI: 10.1016/j.bbrc.2010.11.036

8044  Fujita H, Hirano M, Shimizu K, Nagamori E.  Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise.  J. Muscle Res. Cell. Motil.  2010  31:279-88  PubMed ID: 21120590   DOI: 10.1007/s10974-010-9230-9

8128  Tajika Y, Takahashi M, Hino M, Murakami T, Yorifuji H.  VAMP2 marks quiescent satellite cells and myotubes, but not activated myoblasts.  Acta Histochem Cytochem  2010  43:107-14  PubMed ID: 20824121   DOI: 10.1267/ahc.10010

8147  Konishi H, Okuda A, Ohno Y, Kihara A.  Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients.  J. Biochem.  2010  148:617-22  PubMed ID: 20724468   DOI: 10.1093/jb/mvq092

8161  Itoigawa Y, Kishimoto KN, Okuno H, Sano H, Kaneko K, Itoi E.  Hypoxia induces adipogenic differentitation of myoblastic cell lines.  Biochem. Biophys. Res. Commun.  2010  399:721-6  PubMed ID: 20692234   DOI: 10.1016/j.bbrc.2010.08.007

8162  Kono S, Nishio T, Takahashi Y, Goto-Inoue N, Kinoshita M, Zaima N, Suzuki H, Fukutoku-Otsuji A, Setou M, Miyajima H.  Dominant-negative effects of a novel mutation in the filamin myopathy.  Neurology  2010  75:547-54  PubMed ID: 20697107   DOI: 10.1212/WNL.0b013e3181ec7fbd

8166  Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, Yokota Y, Fukamoto K, Mutou Y, Kobayashi Y, Yorifuji H.  Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.  J Electron Microsc (Tokyo)  2010  59:495-501  PubMed ID: 20685830   DOI: 10.1093/jmicro/dfq059

8182  Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Bone  2010  47:756-65  PubMed ID: 20637325   DOI: 10.1016/j.bone.2010.07.008

8184  Fujita H, Endo A, Shimizu K, Nagamori E.  Evaluation of serum-free differentiation conditions for C2C12 myoblast cells assessed as to active tension generation capability.  Biotechnol. Bioeng.  2010  107:894-901  PubMed ID: 20635352   DOI: 10.1002/bit.22865

8231  Fujita H, Shimizu K, Morioka Y, Nagamori E.  Enhancement of C2C12 differentiation by perfluorocarbon-mediated oxygen delivery.  J. Biosci. Bioeng.  2010  110:359-62  PubMed ID: 20547328   DOI: 10.1016/j.jbiosc.2010.02.012

8259  Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T.  Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials.  Dent Mater J  2010  29:341-6  PubMed ID: 20467157   DOI: 10.4012/dmj.2009-082

8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766   DOI: 10.1248/bpb.33.854

8351  Fujita H, Shimizu K, Nagamori E.  Novel method for measuring active tension generation by C2C12 myotube using UV-crosslinked collagen film.  Biotechnol. Bioeng.  2010  106:482-9  PubMed ID: 20178119   DOI: 10.1002/bit.22705

8352  Miyake M, Hayashi S, Iwasaki S, Chao G, Takahashi H, Watanabe K, Ohwada S, Aso H, Yamaguchi T.  Possible role of TIEG1 as a feedback regulator of myostatin and TGF-beta in myoblasts.  Biochem. Biophys. Res. Commun.  2010  393:762-6  PubMed ID: 20171187   DOI: 10.1016/j.bbrc.2010.02.077

8371  Shimizu K, Fujita H, Nagamori E.  Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis.  J. Biosci. Bioeng.  2010  109:174-8  PubMed ID: 20129103   DOI: 10.1016/j.jbiosc.2009.07.016

8385  Shimizu K, Fujita H, Nagamori E.  Oxygen plasma-treated thermoresponsive polymer surfaces for cell sheet engineering.  Biotechnol. Bioeng.  2010  106:303-10  PubMed ID: 20091737   DOI: 10.1002/bit.22677

8387  Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y.  The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.  Biochem. J.  2010  427:171-8  PubMed ID: 20088826   DOI: 10.1042/BJ20091346

4679  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257   DOI: 10.1242/jcs.071373

8562  Yuasa K, Masuda T, Yoshikawa C, Nagahama M, Matsuda Y, Tsuji A.  Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation.  J. Biochem.  2009  146:407-15  PubMed ID: 19520771   DOI: 10.1093/jb/mvp090

8609  Fujita H, Shimizu K, Nagamori E.  Novel method for fabrication of skeletal muscle construct from the C2C12 myoblast cell line using serum-free medium AIM-V.  Biotechnol. Bioeng.  2009  103:1034-41  PubMed ID: 19350625   DOI: 10.1002/bit.22318

8643  Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K.  RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro.  J. Bone Miner. Metab.  2009  27:402-11  PubMed ID: 19252814   DOI: 10.1007/s00774-009-0054-x

8652  Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473   DOI: 10.1007/s00774-009-0040-3

8683  Takayuki Hoshino, Tomohiro Konno, Kazuhiko Ishihara, and Keisuke Morishima  Live-Cell-Driven Insertion of a Nanoneedle  Jpn J Appl Phys.  2009  48:107002-1-107002-6

8684  Takeomi MIZUTANI, Kenichi DOI, Yasuyuki MORITA, Masakazu UCHINO, Mitsugu TODO, Hisashi HAGA and Kazushige KAWABATA  Displacement of Actin Filament and Actin Binding Proteins under Local Deformation Processed by Digital Image Correlation Method in a Myoblast  J Biomechanical Science and Engineering  2009  4:415-422    DOI: 10.1299/jbse.4.415

8694  Yagi M, Suzuki N, Takayama T, Arisue M, Kodama T, Yoda Y, Otsuka K, Ito K.  Effects of lactoferrin on the differentiation of pluripotent mesenchymal cells.  Cell Biol. Int.  2009  33:283-9  PubMed ID: 19103298   DOI: 10.1016/j.cellbi.2008.11.013

8696  Honda M, Hosoda M, Kanzawa N, Tsuchiya T, Toyo-oka T.  Specific knockdown of delta-sarcoglycan gene in C2C12 in vitro causes post-translational loss of other sarcoglycans without mechanical stress.  Mol. Cell. Biochem.  2009  323:149-59  PubMed ID: 19083155   DOI: 10.1007/s11010-008-9975-2

8766  Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  J Biomed Mater Res A  2009  88:599-607  PubMed ID: 18314893   DOI: 10.1002/jbm.a.31833

6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746   DOI: 10.1186/1471-213X-9-70

8155  Shimizu K, Fujita H, Nagamori E.  Alignment of skeletal muscle myoblasts and myotubes using linear micropatterned surfaces ground with abrasives.  Biotechnol Bioeng  2009  103(3):631-8  PubMed ID: 19189396   DOI: 10.1002/bit.22268

8175  Watanuki M, Kishimoto KN, Kotajima S, Iwabuchi S, Kokubun S.  Effect of low-intensity pulsed ultrasound on scaffold-free ectopic bone formation in skeletal muscle.  Ups J Med Sci  2009  114(4):242-8  PubMed ID: 19961269   DOI: 10.3109/03009730903226659

15633  Ono Y, Gnocchi VF, Zammit PS, Nagatomi R.  Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner  J Cell Sci  2009  122(Pt 24):4427-38  PubMed ID: 19920078   DOI: 10.1242/jcs.049742

18337  Kazama T, Fujie M, Endo T, Kano K.  Mature adipocyte-derived dedifferentiated fat cells can transdifferentiate into skeletal myocytes in vitro  Biochem Biophys Res Commun  2008  377(3):780-5  PubMed ID: 18938140   DOI: 10.1016/j.bbrc.2008.10.046

8727  Yamauchi M, Kawai S, Kato T, Ooshima T, Amano A.  Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors.  Gene  2008  426:81-90  PubMed ID: 18804520   DOI: 10.1016/j.gene.2008.08.015

8741  Herningtyas EH, Okimura Y, Handayaningsih AE, Yamamoto D, Maki T, Iida K, Takahashi Y, Kaji H, Chihara K.  Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.  Biochim. Biophys. Acta  2008  1780:1115-20  PubMed ID: 18616983   DOI: 10.1016/j.bbagen.2008.06.004

6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373

7919  Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K.  Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells.  J Bone Miner Metab  2008  26(2):152-8  PubMed ID: 18301971   DOI: 10.1007/s00774-007-0803-7

7924  Baba TT, Nemoto TK, Miyazaki T, Oida S.  Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.  J Muscle Res Cell Motil  2008  29(2-5):127-34  PubMed ID: 18792797   DOI: 10.1007/s10974-008-9146-9

13954  Jimbo R, Sawase T, Baba K, Kurogi T, Shibata Y, Atsuta M.  Enhanced initial cell responses to chemically modified anodized titanium  Clin Implant Dent Relat Res  2008  10(1):55-61.  PubMed ID: 18254741   DOI: 10.1111/j.1708-8208.2007.00061.x

13958  Kawanishi N, Tanaka Y, Kato Y, Shiva D, Yano H.  Lipopolysaccharide-induced monocyte chemotactic protein-1 is enhanced by suppression of nitric oxide production, which depends on poor CD14 expression on the surface of skeletal muscle  Cell Biochem Funct  2008  26(4):486-9  PubMed ID: 18383566   DOI: 10.1002/cbf.1471

16635  Takayuki Hoshino, Tomohiro Konno, Kazuhiko Ishihara, Keisuke Morishima  Cell Self Assembly of Intracellular Interface Using Cell Migration  MRS Proceedings  2008  1092    DOI: 10.1557/proc-1092-bb02-12

8803  Kawai S, Yamauchi M, Wakisaka S, Ooshima T, Amano A.  Zinc-finger transcription factor odd-skipped related 2 is one of the regulators in osteoblast proliferation and bone formation.  J. Bone Miner. Res.  2007  22:1362-72  PubMed ID: 17547533   DOI: 10.1359/jbmr.070602

8855  Ono Y, Sensui H, Okutsu S, Nagatomi R.  Notch2 negatively regulates myofibroblastic differentiation of myoblasts.  J. Cell. Physiol.  2007  210:358-69  PubMed ID: 17044085   DOI: 10.1002/jcp.20838

7399  Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A.  CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.  Biochem Biophys Res Commun  2007  354(2):567-73  PubMed ID: 17250806   DOI: 10.1016/j.bbrc.2007.01.029

7172  Yu LY, Pei Y, Xia WB, Xing XP, Meng XW, Zhou XY.  Effect of fibroblast growth factor 9 on Runx2 gene promoter activity in MC3T3-E1 and C2C12 cells.  Chin Med J (Engl).   2007  120(6):491-5  PubMed ID: 17439743

7246  Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T.  Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency.  Dev Dyn  2007  236(7):1876-90  PubMed ID: 17497678   DOI: 10.1002/dvdy.21187

13948  Nakanishi K, Dohmae N, Morishima N.  Endoplasmic reticulum stress increases myofiber formation in vitro  FASEB J  2007  21(11):2994-3003  PubMed ID: 17435177   DOI: 10.1096/fj.06-6408com

13955  Nakagawa K, Imai Y, Ohta Y, Takaoka K.  Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation  Bone  2007  41(4):543-8  PubMed ID: 17681894   DOI: 10.1016/j.bone.2007.06.013

3398  Ouyang, Xinshou, Fujimoto, Minoru, Nakagawa, Reiko, Serada, Satoshi, Tanaka, Toshio, Nomura, Shintaro, Kawase, Ichiro, Kishimoto, Tadamitsu, Naka, Tetsuji  SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.  J Cell Physiol  2006  207:428-36  PubMed ID: 16419040   DOI: 10.1002/jcp.20579

3357  Hiroyama, Takashi, Miharada, Kenichi, Aoki, Naoko, Fujioka, Tsuyoshi, Sudo, Kazuhiro, Danjo, Inaho, Nagasawa, Toshiro, Nakamura, Yukio  Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.  Exp Hematol  2006  34:760-9  PubMed ID: 16728281   DOI: 10.1016/j.exphem.2006.03.004

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2873  Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T  Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling.  Biochem Biophys Res Commun  2005  329:381-5  PubMed ID: 15721317   DOI: 10.1016/j.bbrc.2005.01.136

2878  Tsutsumi S, Inoue H, Sakamoto Y, Mizuta K, Kamata N, Itakura M  Molecular cloning and characterization of the murine gnathodiaphyseal dysplasia gene GDD1.  Biochem Biophys Res Commun  2005  331:1099-106  PubMed ID: 15882990   DOI: 10.1016/j.bbrc.2005.03.226

2915  Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, Shindo H, Yamaguchi A  Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.  J Biol Chem  2005  280:15842-8  PubMed ID: 15695512   DOI: 10.1074/jbc.M412891200

3183  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650   DOI: 10.1128/MCB.25.5.1971-1979.2005

3043  Nakanishi K, Sudo T, Morishima N.  Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development.  J Cell Biol  2005  169(4):555-60  PubMed ID: 15897261   DOI: 10.1083/jcb.200412024

3158  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495   DOI: 10.1016/j.yexcr.2003.12.018

2871  Notoya M, Otsuka E, Yamaguchi A, Hagiwara H  Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.  Biochem Biophys Res Commun  2004  324:655-60  PubMed ID: 15474477   DOI: 10.1016/j.bbrc.2004.09.101

2893  Ichida, Fumitaka, Nishimura, Riko, Hata, Kenji, Matsubara, Takuma, Ikeda, Fumiyo, Hisada, Kunihiro, Yatani, Hirofumi, Cao, Xu, Komori, Toshihisa, Yamaguchi, Akira, Yoneda, Toshiyuki  Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation.  J Biol Chem  2004  279:34015-22  PubMed ID: 15175325   DOI: 10.1074/jbc.M403621200

2914  Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E.  Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis.  J. Biol. Chem.  2004  279:50375-81  PubMed ID: 15452118   DOI: 10.1074/jbc.M408493200

6716  Yoshizawa T, Takizawa F, Iizawa F, Ishibashi O, Kawashima H, Matsuda A, Endo N, Kawashima H.  Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.  Mol Cell Biol  2004  24(8):3460-72  PubMed ID: 15060165   DOI: 10.1128/mcb.24.8.3460-3472.2004

15550  Takayuki Akimoto, Takashi Ushida, Shigeru Miyaki, Hiroshi Akaogi, Tetsuya Tateishi, Toru Fukubayashi  Effect of mechanical stretch on TGF-β1 expression of C2C12 myogenic cells  Materials Science and Engineering: C  2004  24:387-389    DOI: 10.1016/j.msec.2003.12.013

2644  Funato N, Ohyama K, Kuroda T, Nakamura M  Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription  J Biol Chem  2003  278:7486-7493  PubMed ID: 12493738   DOI: 10.1074/jbc.M212248200

4978  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046   DOI: 10.1016/j.bbrc.2003.08.058

6710  Otsuka E, Notoya M, Hagiwara H.  Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts.  Calcif Tissue Int  2003  3(1):72-7  PubMed ID: 14506957   DOI: 10.1007/s00223-002-1071-0

1178  Kishida K, Nagaretani H, Kondo H, Kobayashi H, Tanaka S, Maeda N, Nagasawa A, Hibuse T, Ohashi K, Kumada M, Nishizawa H, Okamoto Y, Ouchi N, Maeda K, Kihara S, Funahashi T, Matsuzawa Y.  Disturbed secretion of mutant adiponectin associated with the metabolic syndrome  Biochem Biophys Res Commun  2003  306(1):286-92  PubMed ID: 12788102   DOI: 10.1016/s0006-291x(03)00940-9

3044  Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y.  An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.  J. Biol. Chem.  2002  277:34287-94  PubMed ID: 12097332   DOI: 10.1074/jbc.M204973200

3519  Higuchi C, Myoui A, Hashimoto N, Kuriyama K, Yoshioka K, Yoshikawa H, Itoh K.  Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix.  J Bone Miner Res  2002  17(10):1785-94  PubMed ID: 12369782   DOI: 10.1359/jbmr.2002.17.10.1785

3560  Fujita T, Meguro T, Fukuyama R, Nakamuta H, Koida M.  New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.  J Biol Chem  2002  277(25):22191-200  PubMed ID: 11956184   DOI: 10.1074/jbc.M110364200

3542  Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T.  Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage.  J Biol Chem  2001  276(26):24023-9  PubMed ID: 11292829   DOI: 10.1074/jbc.M100861200

2718  Yang XL, Matsuura H, Fu Y, Sugiyama T, Miura N  MFH-1 is required for bone morphogenetic protein-2-induced osteoblastic differentiation of C2C12 myoblasts.  FEBS Lett  2000  470:29-34  PubMed ID: 10722840   DOI: 10.1016/s0014-5793(00)01285-0

2425  Suzuki J, Kaziro Y, Koide H  Positive regulation of skeletal myogenesis by R-Ras.  Oncogene  2000  19:1138-46  PubMed ID: 10713701   DOI: 10.1038/sj.onc.1203402

2426  Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H  Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.  Mol Cell Biol  2000  20:4658-65  PubMed ID: 10848592   DOI: 10.1128/mcb.20.13.4658-4665.2000

2378  Yamasaki K, Sasaki T, Nemoto M, Eto Y, Tajima N  Differentiation-induced insulin secretion from nonendocrine cells with engineered human proinsulin cDNA.  Biochem Biophys Res Commun  1999  265:361-5  PubMed ID: 10558872   DOI: 10.1006/bbrc.1999.1698

3967  Tomohiro ShimizuJe-Tae WooKazuo Nagai  Screening for Bioactive Compounds that Induce the Differentiation of Bone Marrow-Derived Preadipocytic Cell Line, ST2, into the Cells of Osteoblastic Phenotype  Animal Cell Technology: Basic & Applied Aspects  1999  10:353–356    DOI: 10.1007/0-306-46865-4_61