CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0876 : RGM1]

19888 Taninaka A, Kurokawa H, Kamiyanagi M, Ochiai T, Arashida Y, Takeuchi O, Matsui H, Shigekawa H. Polphylipoprotein-induced autophagy mechanism with high performance in photodynamic therapy Commun Biol 2023 6(1):1212 PubMed ID: 38017279 DOI: 10.1038/s42003-023-05598-0

20643 Kurokawa H, Taninaka A, Yoshitomi T, Shigekawa H, Matsui H. Near-Infrared Light Irradiation of Porphyrin-Modified Gold Nanoparticles Promotes Cancer-Cell-Specific Cytotoxicity. Molecules 2022 27(4) PubMed ID: 35209026 DOI: 10.3390/molecules27041238

20665 Komatsu Y, Yoshitomi T, Furuya K, Ikeda T, Terasaki A, Hoshi A, Kawazoe N, Chen G, Matsui H. Long-Term Fluorescent Tissue Marking Using Tissue-Adhesive Porphyrin with Polycations Consisting of Quaternary Ammonium Salt Groups. Int J Mol Sci 2022 23(8) PubMed ID: 35457034 DOI: 10.3390/ijms23084218

17326 Kamiyanagi M, Taninaka A, Ugajin S, Nagoshi Y, Kurokawa H, Ochiai T, Arashida Y, Takeuchi O, Matsui H, Shigekawa H. Cell-Level Analysis Visualizing Photodynamic Therapy with Porphylipoprotein and Talaporphyrin Sodium Int J Mol Sci 2022 23(21):13140 PubMed ID: 36361927 DOI: 10.3390/ijms232113140

20160 Oshimo M, Nakashima F, Kai K, Matsui H, Shibata T, Akagawa M. Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress. Free Radic Res 2021 1-29 PubMed ID: 34074194 DOI: 10.1080/10715762.2021.1937620

20443 Bravo PLW, Jin H, Park H, Kim MS, Matsui H, Lee H, Suh JW. Antithrombotic Effect of the Ethanol Extract of Angelica gigas Nakai (AGE 232). Life (Basel) 2021 11(9) PubMed ID: 34575088 DOI: 10.3390/life11090939

20467 Kurokawa H, Matsui H. The Cytotoxicity of Doxorubicin Can Be Accelerated by a Combination of Hyperthermia and 5-Aminolevulinic Acid. Antioxidants (Basel) 2021 10(10) PubMed ID: 34679666 DOI: 10.3390/antiox10101531

16132 Hiromi Kurokawa, Hiromu Ito, Hirofumi Matsui Porphylipoprotein Accumulation and Porphylipoprotein Photodynamic Therapy Effects Involving Cancer Cell-Specific Cytotoxicity Int J Mol Sci 2021 22(14):7306 PubMed ID: 34298933 DOI: 10.3390/ijms22147306

16232 Hiromi Kurokawa, Atsushi Taninaka, Hidemi Shigekawa, Hirofumi Matsui Dabigatran Etexilate Induces Cytotoxicity in Rat Gastric Epithelial Cell Line via Mitochondrial Reactive Oxygen Species Production Cells 2021 10(10):2508 PubMed ID: 34685491 DOI: 10.3390/cells10102508

11755 Kurokawa H, Ito H, Matsui H. The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation. Cells 2019 8 PubMed ID: 31426474 DOI: 10.3390/cells8080918

3918 Saito R1, Tamura M1, Matsui H1, Nagano Y1, Suzuki H1, Kaneko T1, Mizokami Y1, Hyodo I1. Qing Dai attenuates nonsteroidal anti-inflammatory drug-induced mitochondrial reactive oxygen species in gastrointestinal epithelial cells. J Clin Biochem Nutr 2015 56(1):8-14 PubMed ID: 25678747 DOI: 10.3164/jcbn.14-59

3915 Okabe S, Okamoto T, Zhao CM, Chen D, Matsui H. Acetic acid induces cell death: an in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines. J Gastroenterol Hepatol 2014 29 Suppl 4:65-9 PubMed ID: 25521736 DOI: 10.1111/jgh.12775

3913 Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai Cancer cells uptake porphyrins via heme carrier protein 1 Journal of Porphyrins and Phthalocyanines 2013 17:36-43 DOI: 10.1142/S1088424612501192

3905 Nagano Y, Matsui H, Tamura M, Shimokawa O, Nakamura Y, Kaneko T, Hyodo I. NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction. Digestion 2012 85(2):131-5 PubMed ID: 22269294 DOI: 10.1159/000334685

3906 Nagano Y, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo HP, Majima HJ, Hyodo I. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells. J Physiol Pharmacol 2012 63(2):137-42 PubMed ID: 22653900

3907 Tatsugami M, Ito M, Tanaka S, Yoshihara M, Matsui H, Haruma K, Chayama K. Bile acid promotes intestinal metaplasia and gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev 2012 21(11):2101-7 PubMed ID: 23010643 DOI: 10.1158/1055-9965.EPI-12-0730

3908 Nagano Y, Matsui H, Shimokawa O, Hirayama A, Nakamura Y, Tamura M, Rai K, Kaneko T, Hyodo I. Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation. J Clin Biochem Nutr 2012 51(3):196-203 PubMed ID: 23170047 DOI: 10.3164/jcbn.12-41

3911 Suemasu S, Yamakawa N, Ishihara T, Asano T, Tahara K, Tanaka K, Matsui H, Okamoto Y, Otsuka M, Takeuchi K, Suzuki H, Mizushima T. Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity. Biochem Pharmacol 2012 84(11):1470-81 PubMed ID: 23022227 DOI: 10.1016/j.bcp.2012.09.016

16813 Okada H, Naito Y, Takagi T, Takaoka M, Oya-Ito T, Fukumoto K, Uchiyama K, Handa O, Kokura S, Nagano Y, Matsui H, Kato Y, Osawa T, Yoshikawa T. Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells J Clin Biochem Nutr 2012 50(1):47-52 PubMed ID: 22247600 DOI: 10.3164/jcbn.11-39

17269 Nakamizo H, Suzuki H, Miura S, Mogami S, Kishikawa H, Yoshida H, Matsui H, Hibi T. Transmural pressure loading enhances gastric mucosal cell proliferation Dig Dis Sci 2012 57(10):2545-54 PubMed ID: 22644739 DOI: 10.1007/s10620-012-2208-2

7751 Rai K, Matsui H, Kaneko T, Nagano Y, Shimokawa O, Udo J, Hirayama A, Hyodo I, Indo HP, Majima HJ. Lansoprazole inhibits mitochondrial superoxide production and cellular lipid peroxidation induced by indomethacin in RGM1 cells. J Clin Biochem Nutr 2011 49:25-30 PubMed ID: 21765603 DOI: 10.3164/jcbn.10-133

16295 Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo HP, Majima HJ, Hyodo I. Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells J Gastroenterol 2011 46(10):1167-76 PubMed ID: 21789481 DOI: 10.1007/s00535-011-0434-6

3898 SB Olaleye, CH Cho Antiulcerogenic Effects of Kolaviron: Inhibition of Apoptosis induced by Indomethacin in the intact Rat Stomach and Rat Gastric Mucosa Cell line African Journal of Biomedical Research 2010 13

8528 Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Matsui H, Yoshikawa T. Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1. J. Pharmacol. Exp. Ther. 2009 331:255-64 PubMed ID: 19628634 DOI: 10.1124/jpet.109.152702

3888 Shimokawa O, Matsui H, Nagano Y, Kaneko T, Shibahara T, Nakahara A, Hyodo I, Yanaka A, Majima HJ, Nakamura Y, Matsuzaki Y. Neoplastic transformation and induction of H+,K+ -adenosine triphosphatase by N-methyl-N'-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line. In Vitro Cell Dev Biol Anim 2008 44(1-2):26-30 PubMed ID: 18034283 DOI: 10.1007/s11626-007-9067-8

3889 Suzuki T, Yoshida N, Nakabe N, Isozaki Y, Kajikawa H, Takagi T, Handa O, Kokura S, Ichikawa H, Naito Y, Matsui H, Yoshikawa T. Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution. J Pharmacol Sci 2008 106(3):469-77 PubMed ID: 18360096 DOI: 10.1254/jphs.fp0071422

3878 Tan A, Nakamura H, Kondo N, Tanito M, Kwon YW, Ahsan MK, Matsui H, Narita M, Yodoi J. Thioredoxin-1 attenuates indomethacin-induced gastric mucosal injury in mice. Free Radic Res 2007 41(8):861-9 PubMed ID: 17654042 DOI: 10.1080/10715760701199618

3879 Kaneko T, Matsui H, Shimokawa O, Nakahara A, Hyodo I. Cellular membrane fluidity measurement by fluorescence polarization in indomethacin-induced gastric cellular injury in vitro. J Gastroenterol 2007 42(12):939-46 PubMed ID: 18085350 DOI: 10.1007/s00535-007-2116-y

3880 Ushida Y, Shimokawa Y, Toida T, Matsui H, Takase M. Bovine alpha-lactalbumin stimulates mucus metabolism in gastric mucosa. J Dairy Sci 2007 90(2):541-6 PubMed ID: 17235130 DOI: 10.3168/jds.S0022-0302(07)71537-0

3883 Sekiguchi F, Saito S, Takaoka K, Hayashi H, Nagataki M, Nagasawa K, Nishikawa H, Matsui H, Kawabata A. Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells. Biochem Pharmacol 2007 73(1):103-14 PubMed ID: 17069767 DOI: 10.1016/j.bcp.2006.09.016

1964 Cha B, Kim KH, Matsui H, Kim H. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells Ann N Y Acad Sci 2007 1096:24-8 PubMed ID: 17405912 DOI: 10.1196/annals.1397.066

3871 Katada K, Naito Y, Mizushima K, Takagi T, Handa O, Kokura S, Ichikawa H, Yoshida N, Matsui H, Yoshikawa T. Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis. Digestion 2006 73(2-3):89-100 PubMed ID: 16788290 DOI: 10.1159/000094039

17265 Nagano Y, Matsui H, Muramatsu M, Shimokawa O, Shibahara T, Yanaka A, Nakahara A, Matsuzaki Y, Tanaka N, Nakamura Y. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells Dig Dis Sci 2005 50 Suppl 1:S76-83 PubMed ID: 16184425 DOI: 10.1007/s10620-005-2810-7

3859 Dairaku N, Kato K, Honda K, Koike T, Iijima K, Imatani A, Sekine H, Ohara S, Matsui H, Shimosegawa T. Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage. J Lab Clin Med 2004 143(3):143-51 PubMed ID: 15007303 DOI: 10.1016/j.lab.2003.11.003

3860 Handa O, Naito Y, Takagi T, Shimozawa M, Kokura S, Yoshida N, Matsui H, Cepinskas G, Kvietys PR, Yoshikawa T. Tumor necrosis factor-alpha-induced cytokine-induced neutrophil chemoattractant-1 (CINC-1) production by rat gastric epithelial cells: role of reactive oxygen species and nuclear factor-kappaB. J Pharmacol Exp Ther 2004 309(2):670-6 PubMed ID: 14747614 DOI: 10.1124/jpet.103.062216

3863 Katada K, Naito Y, Shimozawa M, Mizushima K, Kuroda M, Takagi T, Kokura S, Ichikawa H, Yoshida N, Matsui H, Yoshikawa T. Gene expression analysis following hypoxia-reoxygenation in rat gastric epithelial cells using a high-density oligonucleotide array. Redox Rep 2004 9(6):337-42 PubMed ID: 15720829 DOI: 10.1179/135100004225006849

3864 Kubota Y, Kato K, Dairaku N, Koike T, Iijima K, Imatani A, Sekine H, Ohara S, Matsui H, Shimosegawa T. Contribution of glutamine synthetase to ammonia-induced apoptosis in gastric mucosal cells. Digestion 2004 69(3):140-8 PubMed ID: 15114044 DOI: 10.1159/000078152

3854 Honda K, Kato K, Dairaku N, Iijima K, Koike T, Imatani A, Sekine H, Ohara S, Matsui H, Shimosegawa T. High levels of intracellular ATP prevent nitric oxide-induced apoptosis in rat gastric mucosal cells. Int J Exp Pathol 2003 84(6):281-8 PubMed ID: 14748747 DOI: 10.1111/j.0959-9673.2003.00364.x

17319 Kato S, Aihara E, Nakamura A, Xin H, Matsui H, Kohama K, Takeuchi K. Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection Biochem Pharmacol 2003 66(6):1115-21 PubMed ID: 12963499 DOI: 10.1016/s0006-2952(03)00461-1

3849 Shin VY, Liu ES, Koo MW, Wang JY, Matsui H, Cho CH. Cigarette smoke extracts delay wound healing in the stomach: involvement of polyamine synthesis. Exp Biol Med (Maywood) 2002 227(2):114-24 PubMed ID: 11815675 DOI: 10.1177/153537020222700206

16812 Naito Y, Handa O, Takagi T, Ishikawa T, Imamoto E, Nakagawa S, Yamaguchi T, Yoshida N, Matsui H, Yoshikawa T. Ubiquitin-proteasome inhibitor enhances tumour necrosis factor-alpha-induced apoptosis in rat gastric epithelial cells Aliment Pharmacol Ther 2002 16 Suppl 2:59-66 PubMed ID: 11966525 DOI: 10.1046/j.1365-2036.16.s2.30.x

3840 Matsui H, Murata Y, Kobayashi F, Shiba R, Momo K, Kondo Y, Nakahara A, Muto H. Diclofenac-induced gastric mucosal fluorescence in rats. Dig Dis Sci 2001 46(2):338-44 PubMed ID: 11281183 DOI: 10.1023/a:1005656916830

16941 Dekigai H, Nakamura H, Bai J, Tanito M, Masutani H, Hirota K, Matsui H, Murakami M, Yodoi J. Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes Free Radic Res 2001 35(1):23-30 PubMed ID: 11697114 DOI: 10.1080/10715760100300561

3821 Suzuki H, Mori M, Seto K, Shibata F, Nagahashi S, Kawaguchi C, Suzuki M, Matsui H, Watanabe K, Miura S, Ishii H. Rat CXC chemokine GRO/CINC-1 paradoxically stimulates the growth of gastric epithelial cells. Aliment Pharmacol Ther 2000 14 Suppl 1:94-100. PubMed ID: 10807410 DOI: 10.1046/j.1365-2036.2000.014s1094.x

3822 Akiba S, Hatazawa R, Ono K, Hayama M, Matsui H, Sato T. Transforming growth factor-alpha stimulates prostaglandin generation through cytosolic phospholipase A(2) under the control of p11 in rat gastric epithelial cells. Br J Pharmacol 2000 131(5):1004-10 PubMed ID: 11053223 DOI: 10.1038/sj.bjp.0703637

3824 Y Fujii, T Matsura, M Kai, H Matsui, H Kawasaki, K Yamada Mitochondrial Cytochrome c Release and Caspase-3-Like Protease Activation During Indomethacin-Induced Apoptosis In Rat Gastric Mucosal Cells Proc Soc Exp Biol Med 2000 224(2):102-8 PubMed ID: 10806417 DOI: 10.1046/j.1525-1373.2000.22407.x

3816 Noguchi H, Sakamoto C, Wada K, Akamatsu T, Uchida T, Tatsuguchi A, Matsui H, Fukui H, Fujimori T, Kasuga M. Expression of heregulin alpha, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells. Gastroenterology 1999 117(5):1119-27 PubMed ID: 10535875 DOI: 10.1016/s0016-5085(99)70397-5

2330 Matsui H, Murata Y, Hirano K, Sasaki T, Shiba R, Muto H, Ohno T Hydrogen peroxide-induced cellular injury is associated with increase in endogenous fluorescence from rat gastric mucosal epithelial cell culture: A new method for detecting oxidative cellular injury by fluorescence measurement. J Gastroenterol 1998 33:318-25 PubMed ID: 9658308 DOI: 10.1007/s005350050090

3511 Kusuhara H, Matsuyuki H, Matsuura M, Imayoshi T, Okumoto T, Matsui H. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Eur J Pharmacol 1998 360(2-3):273-80 PubMed ID: 9851595 DOI: 10.1016/s0014-2999(98)00679-7

3512 Nakamura E, Takahashi S, Matsui H, Okabe S. Interleukin-1beta inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers. Dig Dis Sci 1998 43(3):476-84 PubMed ID: 9539640 DOI: 10.1023/a:1018890419648

3810 Yuzuru Kubohara, Kenji Kabeya, Hirofumi Matsui, Koichi Ishikawa Effects of DIF-1, an Anti-Tumor Agent Isolated from Dictyostelium discoideum, on Rat Gastric Mucosal RGM-1 and Leptomeningeal Cells Zoological Science 1998 15(5):713-721 DOI: 10.2108/zsj.15.713

4096 Sawaoka H, Tsuji S, Tsujii M, Gunawan ES, Nakama A, Takei Y, Nagano K, Matsui H, Kawano S, Hori M. Expression of the cyclooxygenase-2 gene in gastric epithelium J Clin Gastroenterol 1997 25 Suppl 1:S105-10 PubMed ID: 9479635 DOI: 10.1097/00004836-199700001-00018

17264 Naito Y, Yoshikawa T, Fujii T, Boku Y, Yagi N, Dao S, Yoshida N, Kondo M, Matsui H, Ohtani-Fujita N, Sakai T. Monochloramine-induced cell growth inhibition J Clin Gastroenterol 1997 25 Suppl 1:S179-85 PubMed ID: 9479646 DOI: 10.1097/00004836-199700001-00029

2049 Hassan S, Kinoshita Y, Min D, Nakata H, Kishi K, Matsushima Y, Asahara M, Wang, H Y, Okada A, Maekawa T, Matsui H, Chiba T Presence of prostaglandin EP4 receptor gene expression in a rat gastric mucosal cell line. Digestion 1996 57:196-200 PubMed ID: 8739095 DOI: 10.1159/000201339

3800 Kobayashi I, Kawano S, Tsuji S, Matsui H, Nakama A, Sawaoka H, Masuda E, Takei Y, Nagano K, Fusamoto H, Ohno T, Fukutomi H, Kamada T. RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell Dev Biol Anim 1996 32(5):259-61 PubMed ID: 8792153 DOI: 10.1007/bf02723056

1762 Matsui H., Hirano K., Murata Y., Sasaki T., Yamada S., Fukutomi H. and Ohno T. Autofluorescence Changes in Hydrogen Peroxide-induced Injury of Gastric Mucosal Cell Monolayer Gastroenterology 1993 104:00:00

1763 Murata Y., Matsui H., Tsushima K., Fukutomi H. and Ohno T. Rebamipide and Idebenone as Potent Inhibitors to Injury of Gastric Mucosal Epithelial Cell Line Induced by Hydrogen Peroxide Gastroenterology 1993 104:00:00

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3890 Wu WK1, Li GR, Wong TM, Wang JY, Yu L, Cho CH. Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. Mol Cell Biochem 2008 308(1-2):219-26 PubMed ID: 17978865 DOI: 10.1007/s11010-007-9631-2

3891 Li H, Cai X, Fan X, Moquin B, Stoicov C, Houghton J. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol 2008 294(1):G263-75 PubMed ID: 17991709 DOI: 10.1152/ajpgi.00267.2007

3892 Ng KM, Cho CH, Chang FY, Luo JC, Lin HC, Lin HY, Chi CW, Lee SD. Omeprazole promotes gastric epithelial cell migration. J Pharm Pharmacol 2008 60(5):655-60 PubMed ID: 18416943 DOI: 10.1211/jpp.60.5.0012

3893 Jones MK1, Padilla OR, Webb NA, Norng M. The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase. J Cell Physiol 2008 215(3):750-64 PubMed ID: 18181150 DOI: 10.1002/jcp.21358

8853 Luo JC, Chi CW, Lin HY, Chang FY, Lu CL, Chen CY, Lee SD. Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation. J. Pharmacol. Exp. Ther. 2007 320:687-94 PubMed ID: 17077316 DOI: 10.1124/jpet.106.113035

3778 Yonezawa D, Sekiguchi F, Miyamoto M, Taniguchi E, Honjo M, Masuko T, Nishikawa H, Kawabata A. A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology 2007 241(1-2):11-8 PubMed ID: 17825973 DOI: 10.1016/j.tox.2007.07.020

3881 Fu HY, Asahi K, Hayashi Y, Eguchi H, Murata H, Tsujii M, Tsuji S, Azuma T, Kawano S. East Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type. J Gastroenterol Hepatol 2007 22(3):355-62 PubMed ID: 17295767 DOI: 10.1111/j.1440-1746.2006.04531.x

3882 Wu WK, Law PT, Wong HP, Lam EK, Tai EK, Shin VY, Cho CH. Shift of homeostasis from parenchymal regeneration to fibroblast proliferation induced by lipopolysaccharide-activated macrophages in gastric mucosal healing in vitro. Wound Repair Regen 2007 15(2):221-6 PubMed ID: 17352754 DOI: 10.1111/j.1524-475X.2007.00208.x

3884 Odashima M, Otaka M, Matsuhashi T, Jin M, Horikawa Y, Ohba R, Itoh H, Watanabe S. Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells. Dig Dis Sci 2007 52(11):3087-91 PubMed ID: 17393320 DOI: 10.1007/s10620-007-9795-3

3885 Nguyen T, Chai J, Li A, Akahoshi T, Tanigawa T, Tarnawski AS. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Am J Pathol 2007 170(4):1219-28 PubMed ID: 17392162 DOI: 10.2353/ajpath.2007.060745

3886 Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Wada I, Horikawa Y, Ohba R, Oyake J, Hatakeyama N, Watanabe S. Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat. Dig Dis Sci 2007 52(2):434-41 PubMed ID: 17216574 DOI: 10.1007/s10620-006-9571-9

3887 Nylander-Koski O, Kiviluoto T, Puolakkainen P, Kivilaakso E, Mustonen H. The effect of nitric oxide, growth factors, and estrogen on gastric cell migration. J Surg Res 2007 143(2):230-7 PubMed ID: 17950324 DOI: 10.1016/j.jss.2006.12.002

8878 Yang YH, Wu WK, Tai EK, Wong HP, Lam EK, So WH, Shin VY, Cho CH. The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Ther. 2006 318:547-54 PubMed ID: 16670350 DOI: 10.1124/jpet.106.102467

8886 Ni Z, Okeley NM, Smart BP, Gelb MH. Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. J. Biol. Chem. 2006 281:16245-55 PubMed ID: 16603549 DOI: 10.1074/jbc.M513874200

3869 Oyake J, Otaka M, Matsuhashi T, Jin M, Odashima M, Komatsu K, Wada I, Horikawa Y, Ohba R, Hatakeyama N, Itoh H, Watanabe S. Over-expression of 70-kDa heat shock protein confers protection against monochloramine-induced gastric mucosal cell injury. Life Sci 2006 79(3):300-5 PubMed ID: 16492383 DOI: 10.1016/j.lfs.2006.01.013

3397 Wu WK, Li GR, Wong HP, Hui MK, Tai EK, Lam EK, Shin VY, Ye YN, Li P, Yang YH, Luo JC, Cho CH. Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. J Cell Physiol 2006 207(2):437-44 PubMed ID: 16331678 DOI: 10.1002/jcp.20576

3872 Shen 1, Sun WH, Xue QP, Wu J, Cheng YL, Ding GX, Fu HY, Tsuji S, Kawano S. Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. J Gastroenterol Hepatic 2006 21(4):754-8. PubMed ID: 16677165 DOI: 10.1111/j.1440-1746.2006.04299.x

3873 Nakagiri A, Fukushima K, Kato S, Takeuchi K. Less irritative action of wine and Japanese sake in rat stomachs: a comparative study with ethanol. Dig Dis Sci 2006 51(2):289-97 PubMed ID: 16534671 DOI: 10.1007/s10620-006-3127-x

3874 M. OTAKA T. MATSUHASHI M. ODASHIMA H. ITOH M. JIN I. WADA K. KOMATSU Y. HORIKAWA R. OHBA J. OYAKE N. HATAKEYAMA S. WATANABE Enhancement of cytoprotective ability and cell restoration in 70‐kDa heat shock protein gene‐transfected rat gastric mucosal cells Aliment Pharmacol Ther 2006 24:272–277 DOI: 10.1111/j.1365-2036.2006.00056.x

3875 Gower WR Jr1, Carter GM, McAfee Q, Solivan SM. Identification, regulation and anti-proliferative role of the NPR-C receptor in gastric epithelial cells. Mol Cell Biochem 2006 293(1-2):103-18 PubMed ID: 16786190 DOI: 10.1007/s11010-006-9234-3

3876 Becker JC, Grosser N, Waltke C, Schulz S, Erdmann K, Domschke W, Schröder H, Pohle T. Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells. Biochem Biophys Res Commun 2006 345(3):1014-21 PubMed ID: 16712795 DOI: 10.1016/j.bbrc.2006.04.170

3429 Stoicov, Calin, Cai, Xun, Li, Hanchen, Klucevsek, Kristine, Carlson, Jane, Saffari, Reza, Houghton, Jeanmarie Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation. Infect Immun 2005 73:6311-21 PubMed ID: 16177302 DOI: 10.1128/IAI.73.10.6311-6321.2005

3367 Luo, Jiing Chyuan, Shin, Vivian Yvonne, Yang, Ying Hua, Wu, William Ka Kei, Ye, Yi Ni, So, Wallace Hau Leung, Chang, Full Young, Cho, Chi Hin Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am J Physiol Gastrointest Liver Physiol 2005 288:G32-8 PubMed ID: 15256360 DOI: 10.1152/ajpgi.00093.2004

2847 Mustonen, Harri, Kiviluoto, Tuula, Paimela, Hannu, Puolakkainen, Pauli, Kivilaakso, Eero Calcium signaling is involved in ethanol-induced volume decrease and gap junction closure in cultured rat gastric mucosal cells. Dig Dis Sci 2005 50:103-10 PubMed ID: 15712646

3192 Mustonen, Harri, Lepisto, Anna, Lehtonen, Sanna, Lehtonen, Eero, Puolakkainen, Pauli, Kivilaakso, Eero CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Biochem Biophys Res Commun 2005 332:426-32 PubMed ID: 15910750 DOI: 10.1016/j.bbrc.2005.04.140

3866 Bidel S, Mustonen H, Khalighi-Sikaroudi G, Lehtonen E, Puolakkainen P, Kiviluoto T, Kivilaakso E. Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells. World J Gastroenterol 2005 11(26):4032-9 PubMed ID: 15996028 DOI: 10.3748/wjg.v11.i26.4032

3868 Yuji Naito et al Rebamipide, a Gastroprotective Drug, Inhibits Indomethacin-Induced Apoptosis in Cultured Rat Gastric Mucosal Cells: Association with the Inhibition of Growth Arrest and DNA Damage-Induced 45α Expression Digestive Diseases and Sciences 2005 5S:104–S112 PubMed ID: 16184411 DOI: 10.1007/s10620-005-2814-3

3858 Takezono Y, Joh T, Oshima T, Suzuki H, Seno K, Yokoyama Y, Alexander JS, Itoh M. Role of prostaglandins in maintaining gastric mucus-cell permeability against acid exposure. J Lab Clin Med 2004 143(1):52-8 PubMed ID: 14749685 DOI: 10.1016/j.lab.2003.09.004

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3862 Tarnawski AS, Chai J, Pai R, Chiou SK. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci 2004 49(2):202-9 PubMed ID: 15104358 DOI: 10.1023/b:ddas.0000017439.60943.5c

3798 Netzer P, Halter F, Ma TY, Hoa N, Nguyen N, Nakamura T, Tarnawski AS. Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing. Digestion 2003 67(3):118-28 PubMed ID: 12853723 DOI: 10.1159/000071291

3851 Sasaki E, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Tarnawski AS, Arakawa T. COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells. Dig Dis Sci 2003 48(12):2257-62 PubMed ID: 14714610 DOI: 10.1023/b:ddas.0000007860.87503.09

3852 Joh T, Takezono Y, Oshima T, Sasaki M, Seno K, Yokoyama Y, Ohara H, Nomura T, Alexander JS, Itoh M. The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells. Aliment Pharmacol Ther 2003 18 Suppl 1:133-8 PubMed ID: 12925151 DOI: 10.1046/j.1365-2036.18.s1.15.x

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3856 Becker JC, Hertel M, Markmann A, Shahin M, Werner S, Domschke W, Pohle T. Dynamics and localization of activin A expression in rat gastric ulcers. Scand J Gastroenterol 2003 38(3):260-7 PubMed ID: 12737440 DOI: 10.1080/00365520310000636a

3857 Aburatani S, Tashiro K, Savoie CJ, Nishizawa M, Hayashi K, Ito Y, Muta S, Yamamoto K, Ogawa M, Enomoto A, Masaki M, Watanabe S, Maki Y, Takahashi Y, Eguchi Y, Sakaki Y, Kuhara S. Discovery of novel transcription control relationships with gene regulatory networks generated from multiple-disruption full genome expression libraries. DNA Res 2003 10(1):1-8 PubMed ID: 12693549 DOI: 10.1093/dnares/10.1.1

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3842 Giap AQ, Tarnawski A, Hoa NT, Akotia V, Ma TY. NSAID inhibition of RGM1 gastric monolayer wound re-epithelialization: comparison of selective Cox-2 versus non-selective Cox inhibitors. Life Sci 2002 70(25):3029-37 PubMed ID: 12138016 DOI: 10.1016/s0024-3205(02)01565-5

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3846 Gao Y, Zhou S, Wen J, Huang M, Xu A. Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat. Life Sci 2002 72(6):731-45 PubMed ID: 12467913 DOI: 10.1016/s0024-3205(02)02301-9

3847 Hirose M, Miwa H, Kobayashi O, Oshida K, Misawa H, Kurosawa A, Watanabe S, Sato N. Inhibition of proliferation of gastric epithelial cells by a cyclooxygenase 2 inhibitor, JTE522, is also mediated by a PGE2-independent pathway. Aliment Pharmacol Ther. 2002 Suppl 2:83-9. PubMed ID: 11966528 DOI: 10.1046/j.1365-2036.16.s2.28.x

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3850 Nakamura E, Hagen SJ. Role of glutamine and arginase in protection against ammonia-induced cell death in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol 2002 283(6):G1264-75 PubMed ID: 12388179 DOI: 10.1152/ajpgi.00235.2002

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3835 Miyazaki Y, Hiraoka S, Tsutsui S, Kitamura S, Shinomura Y, Matsuzawa Y. Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells. Gastroenterology. 2001 120(1):108-16 PubMed ID: 11208719 DOI: 10.1053/gast.2001.20950

3836 Akiba S1, Hatazawa R, Ono K, Kitatani K, Hayama M, Sato T. Secretory phospholipase A2 mediates cooperative prostaglandin generation by growth factor and cytokine independently of preceding cytosolic phospholipase A2 expression in rat gastric epithelial cells. J Biol Chem. 2001 276(24):21854-62 PubMed ID: 11274144 DOI: 10.1074/jbc.M010201200

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3838 Terano A, Sakata-Horie K, Shimada T, Hiraishi H, Yoshiura K, Yoneda M, Takahashi M, Fujimori T. The role of cellular migration in the repair process of gastric epithelial cells. Life Sci 2001 69(25-26):3083-9 PubMed ID: 11758833 DOI: 10.1016/s0024-3205(01)01414-x

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3823 Pai R, Sasaki E, Tarnawski AS. Helicobacter pylori vacuolating cytotoxin (VacA) alters cytoskeleton-associated proteins and interferes with re-epithelialization of wounded gastric epithelial monolayers. Cell Biol Int 2000 24(5):291-301 PubMed ID: 10805963 DOI: 10.1006/cbir.2000.0510

3825 Tominaga K, Higuchi K, Tsuno M, Watanabe T, Fujiwara Y, Kim S, Arakawa T, Iwao H, Kuroki T. Induction of signal transduction pathways in rat gastric epithelial cells stimulated with interleukin-1beta. Aliment Pharmacol Ther 2000 14 Suppl 1:101-8 PubMed ID: 10807411 DOI: 10.1046/j.1365-2036.2000.014s1101.x

3826 Shimada T, Hiraishi H, Terano A. Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2. Life Sci 2000 68(5):539-46 PubMed ID: 11197751 DOI: 10.1016/s0024-3205(00)00959-0

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