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Cell No. : Cell Name
RCB0820 : HKBML  update : 2020/09/24
CommentHuman brain derived lymphoma. Epstein-Barr virus positive.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Ishiwata, Isamu
Originator Ishiwata, I. & Sato, E. & Ishikawa, H.
Year of deposit 1992
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue brain
Case history Lymphoma
Classification cancer
Year of origin 1991
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives HamF12 + 15% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Virus (EBV) EBV (+)
Isozyme LD, NP
Chromosome mode 36-96(50) : /45(1),46(2),47(5),48(37),49(1),96(1)
deposit info
lot info
Reference information Reference 0
User's Publication 9

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User's Publication
9864  Yasuo Takashima, Azusa Hayano, Ryuya Yamanaka  Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells  Clin Cancer Res  2020  26(11):2754-2766  PubMed ID: 32108030
11997  Muta H, Sugita Y, Furuta T, Shiimura Y, Ohshima K, Nakashima K, Sato K, Morioka M, Abe H, Nozawa T, Fujii Y, Kakita A.  Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas.  Neuropathology  2020    PubMed ID: 31925841
11518  Hayano A, Takashima Y, Yamanaka R.  Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells.  Int. J. Clin. Oncol.  2019    PubMed ID: 30993483
11849  Mulazzani M, Huber M, Borchard S, Langer S, Angele B, Schuh E, Meinl E, Dreyling M, Birnbaum T, Straube A, Koedel U, von Baumgarten L.  APRIL and BAFF: novel biomarkers for central nervous system lymphoma.  J Hematol Oncol  2019    PubMed ID: 31615554
6897  Takashima Y, Yoshimura T, Kano Y, Hayano A, Hondoh H, Ikenaka K, Yamanaka R.  Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells.  BMC Cancer  2019  19(1):910  PubMed ID: 31510952
11125  Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y.  The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma.  J Clin Exp Hematop  2018  58(2):95-101  PubMed ID: 29998979
11858  Shinojima N, Fujimoto K, Makino K, Todaka K, Yamada K, Mikami Y, Oda K, Nakamura K, Jono H, Kuratsu JI, Nakamura H, Yano S, Mukasa A.  Clinical significance of polyglutamylation in primary central nervous system lymphoma.  Acta Neuropathol Commun  2018    PubMed ID: 29475458
10300  Takahashi Y, Sawada T, Akahane T, Kawase Y, Ikeda H, Makino K, Nakamura H, Hide T, Yano S, Hashimoto N, Kamada H.  Monocyte chemoattractant protein 1 expression and proliferation in primary central nervous system lymphoma.  Oncol Lett  2017  14:264-270  PubMed ID: 28693163
7310  Mizowaki T, Sasayama T, Tanaka K, Mizukawa K, Takata K, Nakamizo S, Tanaka H, Nagashima H, Nishihara M, Hirose T, Itoh T, Kohmura E.  STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.  J. Neurooncol.  2015  124:165-74  PubMed ID: 26080800

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