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Cell No. : Cell Name
RCB0806 : Jurkat  update : 2020/08/17
CommentHuman T cell line, the same patient as JM. IL-2 productivity of this line was undetermined.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Todokoro, Kazuo
Year of deposit 1992
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 14 years
Tissue blood
Case history acute T cell leukemia
Classification cancer
Memo_1 Mycoplasma was eliminated with MC-210.
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 42-92(50) : 42(2),43(1),44(6),45(21),46(14),47(5)/
Surface antigen CD3(-), CD4(-), CD8(-)
Images
deposit info
lot info
Relational File deposit infolot info
Jurkat_CD3.pdf
Reference information Reference 7
User's Publication 27


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Reference
1640  LaGree KA, Lee AT, Stetten G, Strauss PR.  The human Jurkat (FHCRC-11) cell line is heterogeneous in ploidy and cell size and releases detergent-soluble DNA.  Exp Hematol  1988  16(8):686-90  PubMed ID: 3165345
4749  Wendler I1, Jentsch KD, Schneider J, Hunsmann G.  Efficient replication of HTLV-III and STLV-IIImac in human Jurkat cells.  Med Microbiol Immunol  1987  176(5):273-80  PubMed ID: 2443825
1685  Weiss A, Wiskocil RL, Stobo JD.  The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.  J Immunol  1984  133(1):123-8  PubMed ID: 6327821
1638  Pawelec G, Borowitz A, Krammer PH, Wernet P.  Constitutive interleukin 2 production by the JURKAT human leukemic T cell line.  Eur J Immunol  1982  12(5):387-92  PubMed ID: 6980126
1637  Kahle P, Wernet P, Rehbein A, Kumbier I, Pawelec G.  Cloning of functional human T lymphocytes by limiting dilution: impact of filler cells and interleukin 2 sources on cloning efficiencies.  Scand J Immunol  1981  14(5):493-502  PubMed ID: 6278580
515  Gillis S, Watson J.  Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.  J Exp Med  1980  152(6):1709-19  PubMed ID: 6778951
902  Schneider U, Schwenk HU, Bornkamm G.  Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma.  Int J Cancer  1977  19(5):621-6  PubMed ID: 68013

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User's Publication
10599  Yoshimi Utaka, Gengo Kashiwazaki, Sachiko Tajima, Yuko Fujiwara, Keitaro Sumi, Tomohiro Itoh, Takashi Kitayama  Antiproliferative effects of zerumbone-pendant derivatives on human T-cell lymphoid cell line Jurkat cells  Tetrahedron  2019  75:1343-1350 
7069  Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S.  Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.  Nature  2016  534:402-6  PubMed ID: 27281199
9159  Tsukasa Nakanishi, Yuan Song, Cuiying He 1, Duo Wang, Kentaro Morita, Junichi Tsukada, Tamotsu Kanazawa, Yasuhiro Yoshida  Autophagy Is Associated With Cucurbitacin D-induced Apoptosis in Human T Cell Leukemia Cells  Med Oncol  2016  33 (4), 30  PubMed ID: 26913856
7244  Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.  Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.  Nat Commun  2015  6:8021  PubMed ID: 26282514
7821  Qi H, Takano H, Kato Y, Wu Q, Ogata C, Zhu B, Murata Y, Nakamura Y.  Hydrogen [corrected] peroxide-dependent photocytotoxicity by phloxine B, a xanthene-type food colorant.  Biochim. Biophys. Acta  2011  1810:704-12  PubMed ID: 21565256
7874  Wang F, Fang W, Zhang MR, Zhao M, Liu B, Wang Z, Hua Z, Yang M, Kumata K, Hatori A, Yamasaki T, Yanamoto K, Suzuki K.  Evaluation of chemotherapy response in VX2 rabbit lung cancer with 18F-labeled C2A domain of synaptotagmin I.  J. Nucl. Med.  2011  52:592-9  PubMed ID: 21421722
6237  Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S.  HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.  Atherosclerosis   2011  217(2):407-14  PubMed ID: 21762915
8582  Zhang G, Wu H, Zhu B, Shimoishi Y, Nakamura Y, Murata Y.  Induction of apoptosis by beta-carotene and dimethyl tetrasulfide assisted by UVA irradiation in HL-60 cells.  Biosci. Biotechnol. Biochem.  2009  73:1014-20  PubMed ID: 19420723
8667  Kobayashi K, Yasuda Y, Shintani Y, Sumitomo T, Saga T, Kimura M, Yamamoto A, Mori T, Maeda A, Yamaguchi Y, Morita A.  The development of a filter to enhance the efficacy and safety of excimer light (308 nm) therapy.  Photodermatol Photoimmunol Photomed  2009  25:30-6  PubMed ID: 19152513
9078  Yorihiro Nishimura, Masayuki Shimojima, Yoshio Tano, Tatsuo Miyamura, Takaji Wakita, Hiroyuki Shimizu  Human P-selectin Glycoprotein ligand-1 Is a Functional Receptor for Enterovirus 71  Nat Med  2009  15 (7), 794-7  PubMed ID: 19543284
8761  Okamura A, Hagiwara T, Yamagami S, Yamaguchi M, Shinbo T, Kanamori T, Kondo S, Miwa K, Itagaki I.  Effective cell separation utilizing poly(N-isopropylacrylamide)-grafted polypropylene membrane containing adsorbed antibody.  J. Biosci. Bioeng.  2008  105:221-5  PubMed ID: 18397772
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
2875  Miyoshi N, Naniwa K, Kumagai T, Uchida K, Osawa T, Nakamura Y.  Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli.  Biochem Biophys Res Commun  2005  334(2):466-73  PubMed ID: 16009347
2891  Kishimoto S, Muramatsu M, Gokoh M, Oka S, Waku K, Sugiura T.  Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells.  J Biochem  2005  137(2):217-23  PubMed ID: 15749836
2896  Yamanaka M, Eda S, Beppu M.  Carbohydrate chains and phosphatidylserine successively work as signals for apoptotic cell removal.  Biochem Biophys Res Commun  2005  328(1):273-80  PubMed ID: 15670780
3349  Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M.  A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells.  J Biol Chem  2005  280(47):39284-93  PubMed ID: 16135517
3387  Ogawa Y, Morikawa N, Ohkubo-Suzuki A, Miyoshi S, Arakawa H, Kita Y, Nishimura S.  An epoch-making application of discharge plasma phenomenon to gene-transfer.  Biotechnol Bioeng  2005  92(7):865-70  PubMed ID: 16170826
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112
3403  Ozaki, Kouichi, Inoue, Katsumi, Sato, Hiroshi, Iida, Aritoshi, Ohnishi, Yozo, Sekine, Akihiro, Sato, Hideyuki, Odashiro, Keita, Nobuyoshi, Masakiyo, Hori, Masatsugu, Nakamura, Yusuke, Tanaka, Toshihiro  Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.  Nature  2004  429:72-5  PubMed ID: 15129282
2863  Watanabe M, Kitano T, Kondo T, Yabu T, Taguchi Y, Tashima M, Umehara H, Domae N, Uchiyama T, Okazaki T.  Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosis.  Cancer Res  2004  64(3):1000-7  PubMed ID: 14871831
2884  Miyoshi N, Uchida K, Osawa T, Nakamura Y.  A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation.  Cancer Res  2004  64(6):2134-42  PubMed ID: 15026354
2912  Eda S, Yamanaka M, Beppu M.  Carbohydrate-mediated phagocytic recognition of early apoptotic cells undergoing transient capping of CD43 glycoprotein.  J Biol Chem  2004  279(7):5967-74  PubMed ID: 14613931
2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539
2819  Uchida E, Mizuguchi H, Ishii-Watabe A, Hayakawa T.  Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells.  Biol Pharm Bull  2002  25(7):891-7  PubMed ID: 12132664
9032  N Kiyokawa, T Mori, T Taguchi, M Saito, K Mimori, T Suzuki, T Sekino, N Sato, H Nakajima, Y U Katagiri, T Takeda, J Fujimoto  Activation of the Caspase Cascade During Stx1-induced Apoptosis in Burkitt's Lymphoma Cells  J Cell Biochem  2001  81 (1), 128-42  PubMed ID: 11180403
6246  Ohsawa K, Watanabe Y, Sato H.  Hantaan virus persistently infects marmoset B-lymphoblastoid cell line.  J Vet Med Sci  1995  57(5):931-4  PubMed ID: 8593305



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