Cell No. : Cell Name RCB0777 : HMV-II  update : 2024/05/10
Comment			Melanin producing. Originated from the same site of HMV-I.
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Kasuga, Tsutomu
		Originator	Kasuga, Tsutomu
		Year of deposit	1992
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Race	Japanese
		Gender	Female
		Age at sampling	65 years
		Tissue	vagina
		Disease name	melanoma
		Classification	cancer
		Lifespan	infinite
		Morphology	epithelial-like
		Cellosaurus(Expasy)	CVCL_1282
			deposit info	lot info
		Medium	Medium List
		Culture type		Adherent cells
		Culture medium		HamF12 + 10% FBS
		Antibiotics		Free
		Passage method		0.25% Trypsin
	Culture information	Passage ratio		1 : 8 split
		SC frequency		Subculture : once/week, Medium Renewal : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma/Acholeplasma		(-)
		Virus (HIV)		(-)
		Isozyme		LD, NP, MPI, PepB
		Chromosome mode		61-134(50) : /63(7),64(12),65(16),66(5),66(5),67(2)/
		STR(human)		OK
Images			deposit info	lot info
Reference information		Reference	7
		User's Publication	31

Top

Reference

1535  Nakamura T, Seki S, Matsubara O, Ito S, Kasuga T.  Specific incorporation of 4-S-cysteinylphenol into human melanoma cells.  J Invest Dermatol  1988  90(5):725-8  PubMed ID: 3361142   DOI: 10.1111/1523-1747.ep12560926

127  Yamada I, Seki S, Ito S, Matsubara O, Suzuki S, Kasuga T.  The killing effects of 4-S-cysteinylcatechol and analogues on human melanoma cells  Br J Cancer  1988  58(6):776-8  PubMed ID: 3146990   DOI: 10.1038/bjc.1988.307

1534  Inoue S, Ito S, Imai Y, Kasuga T, Fujita K.  Growth inhibition of melanoma cells by N-protected dopa derivatives.  Biochem Pharmacol  1987  36(20):3537-40  PubMed ID: 3118879   DOI: 10.1016/0006-2952(87)90340-6

1536  Yamada I, Seki S, Matsubara O, Ito S, Suzuki S, Kasuga T.  The cytotoxicity of cysteinylcatechols and related compounds to human melanoma cells in vitro.  J Invest Dermatol  1987  88(5):538-40  PubMed ID: 3572026   DOI: 10.1111/1523-1747.ep12470098

968  Hasumi K, Sakamoto G, Sugano H, Kasuga T, Masubuchi K  Primary malignant melanoma of the vagina: study of four autopsy cases with ultrastructural findings.  Cancer  1978  42:2675-86  PubMed ID: 365316   DOI: 10.1002/1097-0142(197812)42:6<2675::aid-cncr2820420624>3.0.co;2-g

4817  Inada T, Kasuga T, Nojiri I, Hiraoka T, Furuse T.  Comparative study on radiosensitivities of cultured cell lines derived from several human tumors under hypoxic condition.  Gan  1977  68(3):357-62  PubMed ID: 913957

4816  Inada T, Kasuga T, Nojiri I, Furuse T, Hiraoka T.  Linear energy transfer-dependent radiosensitivity of Burkitt lymphoma cells, with special references to human melanoma HMV, HeLa-S3, and L5178Y cells.  Gan  1976  67(3):399-402  PubMed ID: 826441

Top

User's Publication

20835  Mizuta K, Matsubara T, Goto A, Addison WN, Nakatomi M, Matsuo K, Tada-Shigeyama Y, Yaginuma T, Honda H, Yoshioka I, Kokabu S.  Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity.  BMC Cancer  2022  22(1):936  PubMed ID: 36038818   DOI: 10.1186/s12885-022-10033-4

15286  Yuki Ohno, Shiori Kondo, Kiho Tajima, Toshiyuki Shibata, Tomohiro Itoh  Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells  Natural Product Communications  2021  16:1934578X2110192    DOI: 10.1177/1934578x211019264

12992  Taguchi N, Hata T, Kamiya E, Homma T, Kobayashi A, Aoki H, Kunisada T.  Eriodictyon angustifolium extract, but not Eriodictyon californicum extract, reduces human hair greying.  Int J Cosmet Sci  2020    PubMed ID: 32324292   DOI: 10.1111/ics.12620

13388  Zhou S, Sakamoto K.  Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway.  PLoS One  2020    PubMed ID: 33332393   DOI: 10.1371/journal.pone.0243565

6893  Ogawa M, Yaginuma T, Nakatomi C, Nakajima T, Tada-Shigeyama Y, Addison WN, Urata M, Matsubara T, Watanabe K, Matsuo K, Sato T, Honda H, Hikiji H, Watanabe S, Kokabu S.  Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity.  Oncotarget  2019  10(3):404-414  PubMed ID: 30719233   DOI: 10.18632/oncotarget.26552

4233  Homma T, Kageyama S, Nishikawa A, Nagata K.  Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 29654760   DOI: 10.1016/j.bbrc.2018.04.070

9516  Samatiwat P, Takeda K, Satarug S, Ohba K, Kukongviriyapan V, Shibahara S.  Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling.  Biochem. Biophys. Res. Commun.  2016  470:144-9  PubMed ID: 26773496   DOI: 10.1016/j.bbrc.2016.01.010

7161  Ohba K, Takeda K, Yamamoto H, Shibahara S.  Microphthalmia-associated transcription factor is expressed in projection neurons of the mouse olfactory bulb.  Genes Cells  2015  20:1088-102  PubMed ID: 26522736   DOI: 10.1111/gtc.12312

14531  Hisahiro Kai, Koji Matsuno  Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells  Planta Medica Letters  2015  2:e39-e41    DOI: 10.1055/s-0035-1557833

18088  Shinya Kato, Masatsugu Kimura, Nobuhiko Miwa  Radiosensitization by fullerene-C60 dissolved in squalene on human malignant melanoma through lipid peroxidation and enhanced mitochondrial membrane potential  Radiation Physics and Chemistry  2014  97:134-141    DOI: 10.1016/j.radphyschem.2013.11.017

18403  Watanuki Y, Kageyama K, Takayasu S, Matsuzaki Y, Iwasaki Y, Daimon M.  Ultraviolet B radiation-stimulated urocortin 1 is involved in tyrosinase-related protein 1 production in human melanoma HMV-II cells  Peptides  2014  61:93-7  PubMed ID: 25240771   DOI: 10.1016/j.peptides.2014.09.009

15908  Takekoshi S, Nagata H, Kitatani K.  Stimulation of melanogenesis by nordihydroguaiaretic Acid in human melanoma cells  Acta Histochem Cytochem  2014  47(5):203-10  PubMed ID: 25861126   DOI: 10.1267/ahc.14033

16001  Yanagishita T, Yajima I, Kumasaka M, Kawamoto Y, Tsuzuki T, Matsumoto Y, Watanabe D, Kato M.  Actin-binding protein, Espin: a novel metastatic regulator for melanoma  Mol Cancer Res  2014  12(3):440-6  PubMed ID: 24337068   DOI: 10.1158/1541-7786.MCR-13-0468-T

17131  Takekoshi S, Nagata H, Kitatani K.  Flavonoids enhance melanogenesis in human melanoma cells  Tokai J Exp Clin Med  2014  39(3):116-21  PubMed ID: 25248426

6320  Shono M, Yoshioka R, Chatani Y, Hirai Y.  Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.  Cell Struct Funct  2013  38(1):97-107  PubMed ID: 23546178   DOI: 10.1247/csf.12032

16017  Watanabe M, Umezawa K, Higashihara M, Horie R.  Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells  Oncol Res  2013  21(4):173-80  PubMed ID: 24762223   DOI: 10.3727/096504014X13887748696707

17157  Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, Nigawara T, Suda T.  Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells  Mol Cell Endocrinol  2013  370(1-2):42-51  PubMed ID: 23416839   DOI: 10.1016/j.mce.2013.01.022

7610  Thang ND, Yajima I, Nakagawa K, Tsuzuki T, Kumasaka MY, Ohgami N, Ly TB, Iwamoto T, Watanabe D, Kato M.  A novel hairless mouse model for malignant melanoma.  J. Dermatol. Sci.  2012  65:207-12  PubMed ID: 22169325   DOI: 10.1016/j.jdermsci.2011.10.010

7976  Ogi T, Higa M, Maruyama S.  Melanin synthesis inhibitors from Balanophora fungosa.  J. Agric. Food Chem.  2011  59:1109-14  PubMed ID: 21265535   DOI: 10.1021/jf1035542

8083  Kim KS, Choi HW, Yoon HE, Kim IY.  Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation.  J. Biol. Chem.  2010  285:40294-302  PubMed ID: 20952384   DOI: 10.1074/jbc.M110.126821

8288  Takeda K, Takahashi NH, Yoshizawa M, Shibahara S.  Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes.  J. Biochem.  2010  148:139-48  PubMed ID: 20403807   DOI: 10.1093/jb/mvq040

13479  Matsumoto Y, Iwakawa M, Furusawa Y, Ishikawa K, Aoki M, Imadome K, Matsumoto I, Tsujii H, Ando K, Imai T.  Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams  Int J Radiat Biol  2008  84(4):299-314  PubMed ID: 18386195   DOI: 10.1080/09553000801953334

3374  Yanagisawa, Ayano, Endo, Chisato, Okawa, Katsuya, Shitara, Shingo, Kugoh, Hiroyuki, Kakitani, Makoto, Oshimura, Mitsuo, Tomizuka, Kazuma  Generation of chromosome-specific monoclonal antibodies using in vitro-differentiated transchromosomic mouse embryonic stem cells.  Stem Cells  2005  23:1479-88  PubMed ID: 16081665   DOI: 10.1634/stemcells.2004-0369

2758  Harada, Hideki, Saijo, Kaoru, Watanabe, Satoru, Tsuboi, Koji, Nose, Tadao, Ishiwata, Isamu, Ohno, Tadao  Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT.  Jpn J Cancer Res  2002  93:313-9  PubMed ID: 11927014   DOI: 10.1111/j.1349-7006.2002.tb02174.x

13672  Takeda K, Yasumoto Ki, Kawaguchi N, Udono T, Watanabe Ki, Saito H, Takahashi K, Noda M, Shibahara S.  Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations  Biochim Biophys Acta  2002  1574(1):15-23  PubMed ID: 11955610   DOI: 10.1016/s0167-4781(01)00339-6

15611  Udono T, Takahashi K, Yasumoto K, Yoshizawa M, Takeda K, Abe T, Tamai M, Shibahara S.  Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma  Exp Eye Res  2001  72(3):225-34  PubMed ID: 11180971   DOI: 10.1006/exer.2000.0948

12280  K Yasumoto , K Yokoyama, K Shibata, Y Tomita, S Shibahara  Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene  Mol Cell Biol  1995  15(3):1833   PubMed ID: 7862173   DOI: 10.1128/mcb.15.3.1833

17919  Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S.  Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2  Biochim Biophys Acta  1994  1217(3):317-21  PubMed ID: 8148378   DOI: 10.1016/0167-4781(94)90292-5

17920  Yokoyama K, Yasumoto K, Suzuki H, Shibahara S.  Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression  J Biol Chem   1994  269(43):27080-7  PubMed ID: 7929451

12279  K Yasumoto, K Yokoyama, K Shibata, Y Tomita, S Shibahara  Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene  Mol Cell Biol  1994  14(12):8058-70  PubMed ID: 7969144   DOI: 10.1128/mcb.14.12.8058-8070.1994

1619  Suzuki H, Takahashi K, Yasumoto K, Shibahara S.  Activation of the tyrosinase gene promoter by neurofibromin  Biochem Biophys Res Commun  1994  205(3):1984-91  PubMed ID: 7811291   DOI: 10.1006/bbrc.1994.2903