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細胞番号 : 細胞名
RCB0735 : OS-RC-2  update : 2022/12/09
細胞特性(Comment:英)Renal tumor cell from a Japanese. Transplantable to nude mice.
細胞特性(日)日本人腎癌。ヌードマウス移植後も元の腎癌と同様形態の腫瘍を形成する。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Kinouchi, Toshiaki
樹立者 Kinouchi, Toshiaki
寄託日 1992
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
採取組織 kidney
病名 renal cell carcinoma
転移 Yes
転移巣 lung
細胞分類 cancer
初代培養日 1982
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_1626
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
ウィルス(HIV) (-)
アイソザイム検査 LD, NP
染色体検査 68-146(50) : 69(4),70(6),71(10),72(13),73(2),74(3)/
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 5件
Reference(日) 1件
利用者成果(英) 66件
利用者成果(日) 0件

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Reference(英)
56  Kinouchi T, Bander NH, Kotake T.  Reactivities of mouse monoclonal antibody K2.7 to renal cancers in complement dependent cytotoxicity and antibody dependent cell-mediated cytotoxicity  J Urologist  1995  154(1):288-92  PubMed ID: 7776448  
57  Kinouchi T, Kotake T.  Renal cancer specific antitumor activities of a mouse monoclonal antibody K2.7 to human renal cell carcinoma  Hinyokika Kiyo  1992  38(11):1325-31  PubMed ID: 1485589  
58  Kinouchi T, Saiki S, Naoe T, Uenaka A, Kotake T, Shiku H, Nakayama E.  Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma  Cancer Res  1989  49(13):3627-30  PubMed ID: 2659164  
55  Kinouchi T, Nakayama E, Ueda R, Ishiguro S, Uenaka A, Oda H, Kotake T.  Characterization of a kidney antigen defined by a mouse monoclonal antibody K2.7  J Urol  1987  137(1):151-4  PubMed ID: 2432281   DOI: 10.1016/s0022-5347(17)43908-5
1578  Kinouchi T, Kotake T, Mori Y, Abe T  Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).  In Vitro Cell Dev Biol  1985  21:195-9  PubMed ID: 4008433   DOI: 10.1007/BF02620929

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Reference(日)
1676  木内利明, 古武敏彦, Neil H. Brander, Lloyd J. Old  ヒト胃癌に対するマウスモノクロナ-ル抗体(mab K2.7)の抗腫 活性    1991     

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利用者成果(英)
21336  Peng S, Wang Z, Tang P, Wang S, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J, Jiang J, Liu Q.  PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.  Sci Adv  2023  9(31):eadf3566  PubMed ID: 37531433   DOI: 10.1126/sciadv.adf3566
17666  Nitta S, Kandori S, Tanaka K, Sakka S, Siga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.  ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma  Cancer Sci  2022  113(8):2738-2752  PubMed ID: 35670054   DOI: 10.1111/cas.15454
18231  Grubb T, Maganti S, Krill-Burger JM, Fraser C, Stransky L, Radivoyevitch T, Sarosiek KA, Vazquez F, Kaelin WG, Chakraborty AA.  A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer  Clin Cancer Res  2022  28(21):4689-4701  PubMed ID: 35776130   DOI: 10.1158/1078-0432.CCR-22-0669
14882  Miyakuni K, Nishida J, Koinuma D, Nagae G, Aburatani H, Miyazono K, Ehata S.  Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer  Mol Oncol  2022  Jun 16.  PubMed ID: 34133843   DOI: 10.1002/1878-0261.13040
20452  Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.  ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma.  Oncol Rep  2022  47(2)  PubMed ID: 34841437   DOI: 10.3892/or.2021.8234
20706  Nishida J, Miyakuni K, Miyazono K, Ehata S.  An in vivo orthotopic serial passaging model for a metastatic renal cancer study.  STAR Protoc  2022  3(2):101306  PubMed ID: 35496785   DOI: 10.1016/j.xpro.2022.101306
16501  Maishi N, Sakurai Y, Hatakeyama H, Umeyama Y, Nakamura T, Endo R, Alam MT, Li C, Annan DA, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, Hida K.  Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system  Cancer Sci  2022  113(5):1855-1867  PubMed ID: 35266253   DOI: 10.1111/cas.15323
20130  Muramatsu-Maekawa Y, Kawakami K, Fujita Y, Takai M, Kato D, Nakane K, Kato T, Tsuchiya T, Koie T, Miura Y, Ito M, Mizutani K.  Profiling of Serum Extracellular Vesicles Reveals miRNA-4525 as a Potential Biomarker for Advanced Renal Cell Carcinoma.  Cancer Genomics Proteomics  2021  18(3):253-259  PubMed ID: 33893078   DOI: 10.21873/cgp.20256
14869  Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K.  miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells  Sci Rep  2021  11(1):13502  PubMed ID: 34226586   DOI: 10.1038/s41598-021-92879-5
16105  Sasaki K, Nishina S, Yamauchi A, Fukuda K, Hara Y, Yamamura M, Egashira K, Hino K.  Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice  Cell Mol Gastroenterol Hepatol   2021  11(3):739-762  PubMed ID: 33191170   DOI: 10.1016/j.jcmgh.2020.10.010
16366  Emberley E, Pan A, Chen J, Dang R, Gross M, Huang T, Li W, MacKinnon A, Singh D, Sotirovska N, Steggerda SM, Wang T, Parlati F.  The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma  PLoS One  2021  16(11):e0259241  PubMed ID: 34731180   DOI: 10.1371/journal.pone.0259241
17038  Momoi Y, Nishida J, Miyakuni K, Kuroda M, Kubota SI, Miyazono K, Ehata S.  Heterogenous expression of endoglin marks advanced renal cancer with distinct tumor microenvironment fitness  Cancer Sci  2021  112(8):3136-3149  PubMed ID: 34091990   DOI: 10.1111/cas.15007
12059  Sakurai Y, Kato A, Harashima H.  Involvement of Caveolin-1-mediated transcytosis in the intratumoral accumulation of liposomes.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 32087973   DOI: 10.1016/j.bbrc.2020.02.086
12102  Nishida J, Momoi Y, Miyakuni K, Tamura Y, Takahashi K, Koinuma D, Miyazono K, Ehata S.  Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis.  Nat. Cell Biol.  2020    PubMed ID: 32203421   DOI: 10.1038/s41556-020-0491-2
13132  Horie K, Kawakami K, Fujita Y, Matsuda Y, Arai T, Suzui N, Miyazaki T, Koie T, Mizutani K, Ito M.  Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features.  Oncology  2020    PubMed ID: 32726790   DOI: 10.1159/000508688
12326  Taguchi L, Miyakuni K, Morishita Y, Morikawa T, Fukayama M, Miyazono K, Ehata S.  c-Ski accelerates renal cancer progression by attenuating transforming growth factor β signaling  Cancer Sci  2019  110(6):2063-2074  PubMed ID: 30972853   DOI: 10.1111/cas.14018
18124  Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S.  Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer  Clin Cancer Res  2018  24(24):6433-6446  PubMed ID: 30108105   DOI: 10.1158/1078-0432.CCR-18-1727
10739  Nishida J, Miyazono K, Ehata S.  Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms.  Oncogene  2018  37:2197-2212  PubMed ID: 29391598   DOI: 10.1038/s41388-017-0084-0
10839  Tsuchida A, Senda M, Ito A, Saito S, Kiso M, Ando T, Harduin-Lepers A, Matsuda A, Furukawa K, Furukawa K.  Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells.  Sci Rep  2018  8:7017  PubMed ID: 29728594   DOI: 10.1038/s41598-018-25521-6
10073  Yue D, Wang Y, Sun Y, Niu Y, Chang C.  C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion.  Neoplasia  2017  19:135-144  PubMed ID: 28107702   DOI: 10.1016/j.neo.2016.12.003
10482  Horie K, Kawakami K, Fujita Y, Sugaya M, Kameyama K, Mizutani K, Deguchi T, Ito M.  Exosomes expressing carbonic anhydrase 9 promote angiogenesis.  Biochem. Biophys. Res. Commun.  2017  492:356-361  PubMed ID: 28851650   DOI: 10.1016/j.bbrc.2017.08.107
12640  Kibria G, Hatakeyama H, Sato Y, Harashima H.  Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors  Int J Pharm  2016  509(1-2):178-187  PubMed ID: 27234700   DOI: 10.1016/j.ijpharm.2016.05.047
12879  Mizutani A, Koinuma D, Seimiya H, Miyazono K.  The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma  Oncogene  2016  35(27):3514-23  PubMed ID: 26522722   DOI: 10.1038/onc.2015.412
12964  Kato T, Inoue H, Imoto S, Tamada Y, Miyamoto T, Matsuo Y, Nakamura Y, Park JH.  Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells  Oncotarget  2016  7(14):17652-64  PubMed ID: 26933922   DOI: 10.18632/oncotarget.7755
14004  Zhang X, Zong W, Hu Y, Luo N, Cheng W, Han X.  A pH-responsive asymmetric lipid vesicle as drug carrier  J Microencapsul  2016  33(7):663-668  PubMed ID: 27682414   DOI: 10.1080/02652048.2016.1242668
7122  Mizutani K, Tomoda M, Ohno Y, Hayashi H, Fujita Y, Kawakami K, Kameyama K, Kato T, Sugiyama T, Itoh Y, Ito M, Deguchi T.  Effects of Cabazitaxel in Renal Cell Carcinoma Cell Lines.  Anticancer Res.  2015  35:6671-7  PubMed ID: 26637883  
3744  Nakamura R, Oyama T, Tajiri R, Mizokami A, Namiki M, Nakamoto M, Ooi A.  Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.  Cancer Sci  2015  106(5):656-64  PubMed ID: 25726761   DOI: 10.1111/cas.12649
6174  Gao F, Wang J, Ji G, Liu S, Yao Y, Wang T, Wu H, Xia Y, Gong D, Jiang H, Yang H, Zhang X.  Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach.  Technol Cancer Res Treat  2015  14(4):383-94.  PubMed ID: 26269607   DOI: 10.1177/1533034614500416
6336  Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C.  Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status.  Oncotarget  2015  6(31):31203-15  PubMed ID: 26304926   DOI: 10.18632/oncotarget.4522
15128  Yamaguchi A, Usami K, Shimabe M, Hasegawa K, Asada M, Motoki K, Tahara T, Masuda K.  The novel CA IX inhibition antibody chKM4927 shows anti-tumor efficacy in vivo  Anticancer Res  2015  35(4):1997-2004  PubMed ID: 25862852  
3327  Liu Y, Xu Y, Li X, Chen Z.  Smad4 suppresses the progression of renal cell carcinoma via the activation of forkhead box protein H1  Mol Med Rep  2015  11(4):2717-22  PubMed ID: 25482028   DOI: 10.3892/mmr.2014.3061
9957  Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, Harashima H.  Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.  Biol. Pharm. Bull.  2014  37:1742-9  PubMed ID: 25366480   DOI: 10.1248/bpb.b14-00338
5280  Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Nonomura K, Hida K.  Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells.  Cancer Sci  2014  105(5):560-7  PubMed ID: 24602018   DOI: 10.1111/cas.12394
15814  Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K.  Suprabasin as a novel tumor endothelial cell marker  Cancer Sci  2014  105(12):1533-40  PubMed ID: 25283635   DOI: 10.1111/cas.12549
18854  Kibria G, Hatakeyama H, Ohga N, Hida K, Harashima H.  The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells  Biomaterials   2013  34(22):5617-27  PubMed ID: 23623323   DOI: 10.1016/j.biomaterials.2013.03.094
6080  Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma.  Pathol Int  2013  63(1):37-44  PubMed ID: 23356224   DOI: 10.1111/pin.12031
12239  Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima  Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system  Mol Ther  2013  21(6):1195-203  PubMed ID: 23568259   DOI: 10.1038/mt.2013.57
15790  Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagué J.  Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer  Nat Med  2013  19(1):50-6  PubMed ID: 23223005   DOI: 10.1038/nm.3029
6100  Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, Onodera Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  CXCR7: a novel tumor endothelial marker in renal cell carcinoma.  Pathol Int  2012  62(5):309-17  PubMed ID: 22524658   DOI: 10.1111/j.1440-1827.2012.02792.x
16647  Suma T, Miyata K, Anraku Y, Watanabe S, Christie RJ, Takemoto H, Shioyama M, Gouda N, Ishii T, Nishiyama N, Kataoka K.  Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG  ACS Nano  2012  6(8):6693-705  PubMed ID: 22835034   DOI: 10.1021/nn301164a
7814  Ito H, Honda K, Satow R, Arai E, Shitashige M, Ono M, Sakuma T, Sakano S, Naito K, Matsuyama H, Yamada T.  Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney.  Jpn. J. Clin. Oncol.  2011  41:847-53  PubMed ID: 21576114   DOI: 10.1093/jjco/hyr060
3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320   DOI: 10.1186/1471-2199-12-31
8278  Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.  Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.  Int. J. Oncol.  2010  36:1379-86  PubMed ID: 20428760   DOI: 10.3892/ijo_00000622
8328  Umebayashi M, Makizono T, Ichihara H, Matsumoto Y, Ueoka R.  Inhibitory effects of cationic hybrid liposomes on the growth of human renal cell carcinoma.  Anticancer Res.  2010  30:327-37  PubMed ID: 20332436  
8332  Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.  Isolated tumor endothelial cells maintain specific character during long-term culture.  Biochem. Biophys. Res. Commun.  2010  394:947-54  PubMed ID: 20302845   DOI: 10.1016/j.bbrc.2010.03.089
8356  Hosono T, Tanaka T, Tanji K, Nakatani T, Kamitani T.  NUB1, an interferon-inducible protein, mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation.  Br. J. Cancer  2010  102:873-82  PubMed ID: 20160729   DOI: 10.1038/sj.bjc.6605574
6393  Inowa T, Hishikawa K, Matsuzaki Y, Isagawa T, Takeuchi T, Aburatani H, Kitamura T, Fujita T.  GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma.  Stem Cells Int  2010  2010:782967  PubMed ID: 21048853   DOI: 10.4061/2010/782967
6126  Akino T, Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M.  Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors.  Am J Pathol  2009  175(6):2657-67  PubMed ID: 19875502   DOI: 10.2353/ajpath.2009.090202
18123  Moriya F, Ogasawara S, Basaki Y, Akiba J, Kojiro S, Fukahori S, Ishizaki H, Nishida N, Matsuoka K, Kojiro M, Kuwano M, Yano H.  Growth inhibitory effects of pegylated IFN-alpha2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo  Int J Oncol  2008  33(4):647-55  PubMed ID: 18813777   DOI: 10.1016/j.ijrobp.2008.06.320
12791  Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.  Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity  Biol Pharm Bull  2008  31(10):1933-7  PubMed ID: 18827358   DOI: 10.1248/bpb.31.1933
3396  Yamada, Daisuke, Kikuchi, Shinji, Williams, Yuko N, Sakurai-Yageta, Mika, Masuda, Mari, Maruyama, Tomoko, Tomita, Kyoichi, Gutmann, David H, Kakizoe, Tadao, Kitamura, Tadaichi, Kanai, Yae, Murakami, Yoshinori  Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.  Int J Cancer  2006  118:916-23  PubMed ID: 16152585   DOI: 10.1002/ijc.21450
5012  Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.  Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.  Hum Mol Genet  2006  15(6):821-30  PubMed ID: 16439445   DOI: 10.1093/hmg/ddl001
14006  Hirota E, Yan L, Tsunoda T, Ashida S, Fujime M, Shuin T, Miki T, Nakamura Y, Katagiri T.  Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma  Int J Oncol  2006  29(4):799-827.  PubMed ID: 16964377  
3164  Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923   DOI: 10.1021/bi047606a
3344  Chen, Qinzhong, Shinohara, Nobuo, Abe, Takashige, Watanabe, Takafumi, Nonomura, Katsuya, Koyanagi, Tomohiko  Significance of COX-2 expression in human renal cell carcinoma cell lines.  Int J Cancer  2004  108:825-32  PubMed ID: 14712483   DOI: 10.1002/ijc.11646
2661  Kasuya, Yutaka, Hosaka, Yoshio, Matsushima, Hisashi, Goto, Toshitaka, Kitamura, Tadaichi, Okuyama, Akira  Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1.  Int J Urol  2003  10:323-31  PubMed ID: 12757604   DOI: 10.1046/j.1442-2042.2003.00626.x
2548  Sudo, Tatsuhiko, Yagasaki, Yuki, Hama, Hiroshi, Watanabe, Naoko, Osada, Hiroyuki  Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  Biochem Biophys Res Commun  2002  291:838-43  PubMed ID: 11866441   DOI: 10.1006/bbrc.2002.6529
2561  Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T  Differences in cell kinetic changes among renal cancer cell lines treated with interferon-alpha.  Int J Urol  2001  8:449-54  PubMed ID: 11555012   DOI: 10.1046/j.1442-2042.2001.00346.x
2441  Tsurushima H, Liu SQ, Tuboi K, Matsumura A, Yoshii Y, Nose T, Saijo K, Ohno T.  Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes  Jpn J Cancer Res  1999  90(5):536-45  PubMed ID: 10391094   DOI: 10.1111/j.1349-7006.1999.tb00781.x
2318  Liu SQ, Kawai K, Shiraiwa H, Hayashi H, Akaza H, Hashizaki K, Shiba R, Saijo K, Ohno T.  High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail.  Jpn J Cancer Res  1998  89(11):1195-201  PubMed ID: 9914789   DOI: 10.1111/j.1349-7006.1998.tb00515.x
1958  Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads.  Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads  Cytotechnology  1998  26(1):13-21  PubMed ID: 22359002   DOI: 10.1023/A:1007924430570
2061  Sugimoto H, Nishino H  [Effect of recombinant human basic fibroblast growth factor (bFGF) on the growth of human tumor cell lines]  Hum Cell  1996  9:129-40  PubMed ID: 9183641  
17992  Inoue M, Yano H, Kojiro M.  Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma  Int J Oncol  1996  9(1):49-56  PubMed ID: 21541480   DOI: 10.3892/ijo.9.1.49
2122  Liu, S Q, Shiraiwa H, Kawai K, Hayashi H, Akaza H, Kim, B S, Oki A, Nishida M, Kubo T, Hashizaki K, Saijo K, Ohno T  Tumor-Specific Autologous Cytotoxic T Lymphocytes from Tissue Sections  Nat Med  1996  2(12):1283  PubMed ID: 8946818   DOI: 10.1038/nm1296-1283
17231  Ogose A, Motoyama T, Hotta T, Watanabe H.  Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells  Pathol Int  1996  46(1):9-14  PubMed ID: 10846544   DOI: 10.1111/j.1440-1827.1996.tb03527.x
1902  Shu Qin Liu, Kaoru Saijo, Makoto Kodama, Tadao Ohno  Intelligent matrices for tumor-specific cytotoxic T lymphocytes  Materials Science and Engineering: C  1994  2:61-65    DOI: 10.1016/0928-4931(94)90030-2

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