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Cell No. : Cell Name
RCB0735 : OS-RC-2  update : 2020/09/24
CommentRenal tumor cell from a Japanese. Transplantable to nude mice.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Kinouchi, Toshiaki
Originator Kinouchi, Toshiaki
Year of deposit 1992
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue kidney
Case history renal cell carcinoma
Metastastatic ability Yes
Metastatsd tissue lung
Classification cancer
Year of origin 1982
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 68-146(50) : 69(4),70(6),71(10),72(13),73(2),74(3)/
Images
deposit info
lot info
Reference information Reference 1
User's Publication 34


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Reference
1578  Kinouchi T, Kotake T, Mori Y, Abe T  Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).  In Vitro Cell Dev Biol  1985  21:195-9  PubMed ID: 4008433

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User's Publication
12059  Sakurai Y, Kato A, Harashima H.  Involvement of Caveolin-1-mediated transcytosis in the intratumoral accumulation of liposomes.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 32087973
12102  Nishida J, Momoi Y, Miyakuni K, Tamura Y, Takahashi K, Koinuma D, Miyazono K, Ehata S.  Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis.  Nat. Cell Biol.  2020    PubMed ID: 32203421
12326  Taguchi L, Miyakuni K, Morishita Y, Morikawa T, Fukayama M, Miyazono K, Ehata S.  c-Ski accelerates renal cancer progression by attenuating transforming growth factor β signaling  Cancer Sci  2019  110(6):2063-2074  PubMed ID: 30972853
10739  Nishida J, Miyazono K, Ehata S.  Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms.  Oncogene  2018  37:2197-2212  PubMed ID: 29391598
10839  Tsuchida A, Senda M, Ito A, Saito S, Kiso M, Ando T, Harduin-Lepers A, Matsuda A, Furukawa K, Furukawa K.  Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells.  Sci Rep  2018  8:7017  PubMed ID: 29728594
10073  Yue D, Wang Y, Sun Y, Niu Y, Chang C.  C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion.  Neoplasia  2017  19:135-144  PubMed ID: 28107702
10482  Horie K, Kawakami K, Fujita Y, Sugaya M, Kameyama K, Mizutani K, Deguchi T, Ito M.  Exosomes expressing carbonic anhydrase 9 promote angiogenesis.  Biochem. Biophys. Res. Commun.  2017  492:356-361  PubMed ID: 28851650
7122  Mizutani K, Tomoda M, Ohno Y, Hayashi H, Fujita Y, Kawakami K, Kameyama K, Kato T, Sugiyama T, Itoh Y, Ito M, Deguchi T.  Effects of Cabazitaxel in Renal Cell Carcinoma Cell Lines.  Anticancer Res.  2015  35:6671-7  PubMed ID: 26637883
3744  Nakamura R, Oyama T, Tajiri R, Mizokami A, Namiki M, Nakamoto M, Ooi A.  Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.  Cancer Sci  2015  106(5):656-64  PubMed ID: 25726761
6174  Gao F, Wang J, Ji G, Liu S, Yao Y, Wang T, Wu H, Xia Y, Gong D, Jiang H, Yang H, Zhang X.  Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach.  Technol Cancer Res Treat  2015  14(4):383-94.  PubMed ID: 26269607
6336  Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C.  Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status.  Oncotarget  2015  6(31):31203-15  PubMed ID: 26304926
9957  Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, Harashima H.  Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.  Biol. Pharm. Bull.  2014  37:1742-9  PubMed ID: 25366480
5280  Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Nonomura K, Hida K.  Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells.  Cancer Sci  2014  105(5):560-7  PubMed ID: 24602018
6080  Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma.  Pathol Int  2013  63(1):37-44  PubMed ID: 23356224
12239  Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima  Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system  Mol Ther  2013  21(6):1195-203  PubMed ID: 23568259
6100  Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, Onodera Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  CXCR7: a novel tumor endothelial marker in renal cell carcinoma.  Pathol Int  2012  62(5):309-17  PubMed ID: 22524658
7814  Ito H, Honda K, Satow R, Arai E, Shitashige M, Ono M, Sakuma T, Sakano S, Naito K, Matsuyama H, Yamada T.  Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney.  Jpn. J. Clin. Oncol.  2011  41:847-53  PubMed ID: 21576114
3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320
8278  Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.  Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.  Int. J. Oncol.  2010  36:1379-86  PubMed ID: 20428760
8328  Umebayashi M, Makizono T, Ichihara H, Matsumoto Y, Ueoka R.  Inhibitory effects of cationic hybrid liposomes on the growth of human renal cell carcinoma.  Anticancer Res.  2010  30:327-37  PubMed ID: 20332436
8332  Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.  Isolated tumor endothelial cells maintain specific character during long-term culture.  Biochem. Biophys. Res. Commun.  2010  394:947-54  PubMed ID: 20302845
8356  Hosono T, Tanaka T, Tanji K, Nakatani T, Kamitani T.  NUB1, an interferon-inducible protein, mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation.  Br. J. Cancer  2010  102:873-82  PubMed ID: 20160729
6393  Inowa T, Hishikawa K, Matsuzaki Y, Isagawa T, Takeuchi T, Aburatani H, Kitamura T, Fujita T.  GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma.  Stem Cells Int  2010  2010:782967  PubMed ID: 21048853
6126  Akino T, Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M.  Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors.  Am J Pathol  2009  175(6):2657-67  PubMed ID: 19875502
3396  Yamada, Daisuke, Kikuchi, Shinji, Williams, Yuko N, Sakurai-Yageta, Mika, Masuda, Mari, Maruyama, Tomoko, Tomita, Kyoichi, Gutmann, David H, Kakizoe, Tadao, Kitamura, Tadaichi, Kanai, Yae, Murakami, Yoshinori  Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.  Int J Cancer  2006  118:916-23  PubMed ID: 16152585
5012  Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.  Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.  Hum Mol Genet  2006  15(6):821-30  PubMed ID: 16439445
3164  Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923
3344  Chen, Qinzhong, Shinohara, Nobuo, Abe, Takashige, Watanabe, Takafumi, Nonomura, Katsuya, Koyanagi, Tomohiko  Significance of COX-2 expression in human renal cell carcinoma cell lines.  Int J Cancer  2004  108:825-32  PubMed ID: 14712483
2661  Kasuya, Yutaka, Hosaka, Yoshio, Matsushima, Hisashi, Goto, Toshitaka, Kitamura, Tadaichi, Okuyama, Akira  Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1.  Int J Urol  2003  10:323-31  PubMed ID: 12757604
2548  Sudo, Tatsuhiko, Yagasaki, Yuki, Hama, Hiroshi, Watanabe, Naoko, Osada, Hiroyuki  Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  Biochem Biophys Res Commun  2002  291:838-43  PubMed ID: 11866441
2561  Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T  Differences in cell kinetic changes among renal cancer cell lines treated with interferon-alpha.  Int J Urol  2001  8:449-54  PubMed ID: 11555012
2318  Liu SQ, Kawai K, Shiraiwa H, Hayashi H, Akaza H, Hashizaki K, Shiba R, Saijo K, Ohno T.  High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail.  Jpn J Cancer Res  1998  89(11):1195-201  PubMed ID: 9914789
2061  Sugimoto H, Nishino H  [Effect of recombinant human basic fibroblast growth factor (bFGF) on the growth of human tumor cell lines]  Hum Cell  1996  9:129-40  PubMed ID: 9183641
2122  Liu, S Q, Shiraiwa H, Kawai K, Hayashi H, Akaza H, Kim, B S, Oki A, Nishida M, Kubo T, Hashizaki K, Saijo K, Ohno T  Tumor-Specific Autologous Cytotoxic T Lymphocytes from Tissue Sections  Nat Med  1996  2(12):1283  PubMed ID: 8946818



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