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Cell No. : Cell Name
RCB0735 : OS-RC-2  update : 2024/08/14
CommentRenal tumor cell from a Japanese. Transplantable to nude mice.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Kinouchi, Toshiaki
Originator Kinouchi, Toshiaki
Year of deposit 1992
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue kidney
Disease name renal cell carcinoma
Metastatic ability Yes
Metastatic tissue lung
Classification cancer
Year of origin 1982
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1626
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 68-146(50) : 69(4),70(6),71(10),72(13),73(2),74(3)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 73


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Reference
56  Kinouchi T, Bander NH, Kotake T.  Reactivities of mouse monoclonal antibody K2.7 to renal cancers in complement dependent cytotoxicity and antibody dependent cell-mediated cytotoxicity  J Urologist  1995  154(1):288-92  PubMed ID: 7776448  
57  Kinouchi T, Kotake T.  Renal cancer specific antitumor activities of a mouse monoclonal antibody K2.7 to human renal cell carcinoma  Hinyokika Kiyo  1992  38(11):1325-31  PubMed ID: 1485589  
58  Kinouchi T, Saiki S, Naoe T, Uenaka A, Kotake T, Shiku H, Nakayama E.  Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma  Cancer Res  1989  49(13):3627-30  PubMed ID: 2659164  
55  Kinouchi T, Nakayama E, Ueda R, Ishiguro S, Uenaka A, Oda H, Kotake T.  Characterization of a kidney antigen defined by a mouse monoclonal antibody K2.7  J Urol  1987  137(1):151-4  PubMed ID: 2432281   DOI: 10.1016/s0022-5347(17)43908-5
1578  Kinouchi T, Kotake T, Mori Y, Abe T  Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).  In Vitro Cell Dev Biol  1985  21:195-9  PubMed ID: 4008433   DOI: 10.1007/BF02620929

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User's Publication
22243  Wilkinson E.  The epidemiology of burns in secondary care, in a population of 2.6 million people.  Burns  2024  24(2):139-43  PubMed ID: 9625239   DOI: 10.1016/s0305-4179(98)80001-6
21336  Peng S, Wang Z, Tang P, Wang S, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J, Jiang J, Liu Q.  PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.  Sci Adv  2023  9(31):eadf3566  PubMed ID: 37531433   DOI: 10.1126/sciadv.adf3566
22192  Fang L, Yuan S, Wang M, Zhang C, Wang X, Li H, Yang J, Li W, Sun N, Zhang Q, Zhang Y, Chai D, Li H, Zheng J, Wang G.  Recombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors  Cell Death Discov  2023  9(1):328  PubMed ID: 37660142   DOI: 10.1038/s41420-023-01626-4
17666  Nitta S, Kandori S, Tanaka K, Sakka S, Siga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.  ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma  Cancer Sci  2022  113(8):2738-2752  PubMed ID: 35670054   DOI: 10.1111/cas.15454
18231  Grubb T, Maganti S, Krill-Burger JM, Fraser C, Stransky L, Radivoyevitch T, Sarosiek KA, Vazquez F, Kaelin WG, Chakraborty AA.  A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer  Clin Cancer Res  2022  28(21):4689-4701  PubMed ID: 35776130   DOI: 10.1158/1078-0432.CCR-22-0669
14882  Miyakuni K, Nishida J, Koinuma D, Nagae G, Aburatani H, Miyazono K, Ehata S.  Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer  Mol Oncol  2022  Jun 16.  PubMed ID: 34133843   DOI: 10.1002/1878-0261.13040
20452  Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.  ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma.  Oncol Rep  2022  47(2)  PubMed ID: 34841437   DOI: 10.3892/or.2021.8234
20706  Nishida J, Miyakuni K, Miyazono K, Ehata S.  An in vivo orthotopic serial passaging model for a metastatic renal cancer study.  STAR Protoc  2022  3(2):101306  PubMed ID: 35496785   DOI: 10.1016/j.xpro.2022.101306
16501  Maishi N, Sakurai Y, Hatakeyama H, Umeyama Y, Nakamura T, Endo R, Alam MT, Li C, Annan DA, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, Hida K.  Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system  Cancer Sci  2022  113(5):1855-1867  PubMed ID: 35266253   DOI: 10.1111/cas.15323
19294  Kawatani M, Aono H, Shimizu T, Ohkura S, Hiranuma S, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Osada H.  Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth  ACS Chem Biol  2021  16(11):2570-2580  PubMed ID: 34730931   DOI: 10.1021/acschembio.1c00625
20130  Muramatsu-Maekawa Y, Kawakami K, Fujita Y, Takai M, Kato D, Nakane K, Kato T, Tsuchiya T, Koie T, Miura Y, Ito M, Mizutani K.  Profiling of Serum Extracellular Vesicles Reveals miRNA-4525 as a Potential Biomarker for Advanced Renal Cell Carcinoma.  Cancer Genomics Proteomics  2021  18(3):253-259  PubMed ID: 33893078   DOI: 10.21873/cgp.20256
14869  Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K.  miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells  Sci Rep  2021  11(1):13502  PubMed ID: 34226586   DOI: 10.1038/s41598-021-92879-5
16105  Sasaki K, Nishina S, Yamauchi A, Fukuda K, Hara Y, Yamamura M, Egashira K, Hino K.  Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in Liver Tumors in Mice  Cell Mol Gastroenterol Hepatol   2021  11(3):739-762  PubMed ID: 33191170   DOI: 10.1016/j.jcmgh.2020.10.010
16366  Emberley E, Pan A, Chen J, Dang R, Gross M, Huang T, Li W, MacKinnon A, Singh D, Sotirovska N, Steggerda SM, Wang T, Parlati F.  The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma  PLoS One  2021  16(11):e0259241  PubMed ID: 34731180   DOI: 10.1371/journal.pone.0259241
17038  Momoi Y, Nishida J, Miyakuni K, Kuroda M, Kubota SI, Miyazono K, Ehata S.  Heterogenous expression of endoglin marks advanced renal cancer with distinct tumor microenvironment fitness  Cancer Sci  2021  112(8):3136-3149  PubMed ID: 34091990   DOI: 10.1111/cas.15007
12059  Sakurai Y, Kato A, Harashima H.  Involvement of Caveolin-1-mediated transcytosis in the intratumoral accumulation of liposomes.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 32087973   DOI: 10.1016/j.bbrc.2020.02.086
12102  Nishida J, Momoi Y, Miyakuni K, Tamura Y, Takahashi K, Koinuma D, Miyazono K, Ehata S.  Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis.  Nat. Cell Biol.  2020    PubMed ID: 32203421   DOI: 10.1038/s41556-020-0491-2
13132  Horie K, Kawakami K, Fujita Y, Matsuda Y, Arai T, Suzui N, Miyazaki T, Koie T, Mizutani K, Ito M.  Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features.  Oncology  2020    PubMed ID: 32726790   DOI: 10.1159/000508688
12326  Taguchi L, Miyakuni K, Morishita Y, Morikawa T, Fukayama M, Miyazono K, Ehata S.  c-Ski accelerates renal cancer progression by attenuating transforming growth factor β signaling  Cancer Sci  2019  110(6):2063-2074  PubMed ID: 30972853   DOI: 10.1111/cas.14018
18124  Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S.  Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer  Clin Cancer Res  2018  24(24):6433-6446  PubMed ID: 30108105   DOI: 10.1158/1078-0432.CCR-18-1727
10739  Nishida J, Miyazono K, Ehata S.  Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms.  Oncogene  2018  37:2197-2212  PubMed ID: 29391598   DOI: 10.1038/s41388-017-0084-0
10839  Tsuchida A, Senda M, Ito A, Saito S, Kiso M, Ando T, Harduin-Lepers A, Matsuda A, Furukawa K, Furukawa K.  Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells.  Sci Rep  2018  8:7017  PubMed ID: 29728594   DOI: 10.1038/s41598-018-25521-6
10073  Yue D, Wang Y, Sun Y, Niu Y, Chang C.  C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion.  Neoplasia  2017  19:135-144  PubMed ID: 28107702   DOI: 10.1016/j.neo.2016.12.003
10482  Horie K, Kawakami K, Fujita Y, Sugaya M, Kameyama K, Mizutani K, Deguchi T, Ito M.  Exosomes expressing carbonic anhydrase 9 promote angiogenesis.  Biochem. Biophys. Res. Commun.  2017  492:356-361  PubMed ID: 28851650   DOI: 10.1016/j.bbrc.2017.08.107
12640  Kibria G, Hatakeyama H, Sato Y, Harashima H.  Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors  Int J Pharm  2016  509(1-2):178-187  PubMed ID: 27234700   DOI: 10.1016/j.ijpharm.2016.05.047
12879  Mizutani A, Koinuma D, Seimiya H, Miyazono K.  The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma  Oncogene  2016  35(27):3514-23  PubMed ID: 26522722   DOI: 10.1038/onc.2015.412
12964  Kato T, Inoue H, Imoto S, Tamada Y, Miyamoto T, Matsuo Y, Nakamura Y, Park JH.  Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells  Oncotarget  2016  7(14):17652-64  PubMed ID: 26933922   DOI: 10.18632/oncotarget.7755
14004  Zhang X, Zong W, Hu Y, Luo N, Cheng W, Han X.  A pH-responsive asymmetric lipid vesicle as drug carrier  J Microencapsul  2016  33(7):663-668  PubMed ID: 27682414   DOI: 10.1080/02652048.2016.1242668
7122  Mizutani K, Tomoda M, Ohno Y, Hayashi H, Fujita Y, Kawakami K, Kameyama K, Kato T, Sugiyama T, Itoh Y, Ito M, Deguchi T.  Effects of Cabazitaxel in Renal Cell Carcinoma Cell Lines.  Anticancer Res.  2015  35:6671-7  PubMed ID: 26637883  
3744  Nakamura R, Oyama T, Tajiri R, Mizokami A, Namiki M, Nakamoto M, Ooi A.  Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.  Cancer Sci  2015  106(5):656-64  PubMed ID: 25726761   DOI: 10.1111/cas.12649
6174  Gao F, Wang J, Ji G, Liu S, Yao Y, Wang T, Wu H, Xia Y, Gong D, Jiang H, Yang H, Zhang X.  Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach.  Technol Cancer Res Treat  2015  14(4):383-94.  PubMed ID: 26269607   DOI: 10.1177/1533034614500416
6336  Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C.  Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status.  Oncotarget  2015  6(31):31203-15  PubMed ID: 26304926   DOI: 10.18632/oncotarget.4522
15128  Yamaguchi A, Usami K, Shimabe M, Hasegawa K, Asada M, Motoki K, Tahara T, Masuda K.  The novel CA IX inhibition antibody chKM4927 shows anti-tumor efficacy in vivo  Anticancer Res  2015  35(4):1997-2004  PubMed ID: 25862852  
3327  Liu Y, Xu Y, Li X, Chen Z.  Smad4 suppresses the progression of renal cell carcinoma via the activation of forkhead box protein H1  Mol Med Rep  2015  11(4):2717-22  PubMed ID: 25482028   DOI: 10.3892/mmr.2014.3061
9957  Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, Harashima H.  Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.  Biol. Pharm. Bull.  2014  37:1742-9  PubMed ID: 25366480   DOI: 10.1248/bpb.b14-00338
5280  Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Nonomura K, Hida K.  Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells.  Cancer Sci  2014  105(5):560-7  PubMed ID: 24602018   DOI: 10.1111/cas.12394
15814  Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K.  Suprabasin as a novel tumor endothelial cell marker  Cancer Sci  2014  105(12):1533-40  PubMed ID: 25283635   DOI: 10.1111/cas.12549
18854  Kibria G, Hatakeyama H, Ohga N, Hida K, Harashima H.  The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells  Biomaterials   2013  34(22):5617-27  PubMed ID: 23623323   DOI: 10.1016/j.biomaterials.2013.03.094
6080  Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma.  Pathol Int  2013  63(1):37-44  PubMed ID: 23356224   DOI: 10.1111/pin.12031
12239  Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima  Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system  Mol Ther  2013  21(6):1195-203  PubMed ID: 23568259   DOI: 10.1038/mt.2013.57
15790  Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagué J.  Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer  Nat Med  2013  19(1):50-6  PubMed ID: 23223005   DOI: 10.1038/nm.3029
6100  Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, Onodera Y, Shinohara N, Nonomura K, Shindoh M, Hida K.  CXCR7: a novel tumor endothelial marker in renal cell carcinoma.  Pathol Int  2012  62(5):309-17  PubMed ID: 22524658   DOI: 10.1111/j.1440-1827.2012.02792.x
16647  Suma T, Miyata K, Anraku Y, Watanabe S, Christie RJ, Takemoto H, Shioyama M, Gouda N, Ishii T, Nishiyama N, Kataoka K.  Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG  ACS Nano  2012  6(8):6693-705  PubMed ID: 22835034   DOI: 10.1021/nn301164a
7814  Ito H, Honda K, Satow R, Arai E, Shitashige M, Ono M, Sakuma T, Sakano S, Naito K, Matsuyama H, Yamada T.  Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney.  Jpn. J. Clin. Oncol.  2011  41:847-53  PubMed ID: 21576114   DOI: 10.1093/jjco/hyr060
19029  Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y.  LRRN4 and UPK3B are markers of primary mesothelial cells  PLoS One  2011  6(10):e25391  PubMed ID: 21984916   DOI: 10.1371/journal.pone.0025391
3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320   DOI: 10.1186/1471-2199-12-31
8278  Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.  Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.  Int. J. Oncol.  2010  36:1379-86  PubMed ID: 20428760   DOI: 10.3892/ijo_00000622
8328  Umebayashi M, Makizono T, Ichihara H, Matsumoto Y, Ueoka R.  Inhibitory effects of cationic hybrid liposomes on the growth of human renal cell carcinoma.  Anticancer Res.  2010  30:327-37  PubMed ID: 20332436  
8332  Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.  Isolated tumor endothelial cells maintain specific character during long-term culture.  Biochem. Biophys. Res. Commun.  2010  394:947-54  PubMed ID: 20302845   DOI: 10.1016/j.bbrc.2010.03.089
8356  Hosono T, Tanaka T, Tanji K, Nakatani T, Kamitani T.  NUB1, an interferon-inducible protein, mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation.  Br. J. Cancer  2010  102:873-82  PubMed ID: 20160729   DOI: 10.1038/sj.bjc.6605574
18946  El-Beialy W, Galal N, Deyama Y, Yoshimura Y, Suzuki K, Tei K, Totsuka Y.  Regulation of human and pig renal Na(+),K (+)-ATPase activity by tyrosine phosphorylation of their alpha(1)-subunits  J Membr Biol  2010  233(1-3):119-26  PubMed ID: 20130847   DOI: 10.1007/s00232-010-9231-z
6393  Inowa T, Hishikawa K, Matsuzaki Y, Isagawa T, Takeuchi T, Aburatani H, Kitamura T, Fujita T.  GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma.  Stem Cells Int  2010  2010:782967  PubMed ID: 21048853   DOI: 10.4061/2010/782967
6126  Akino T, Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M.  Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors.  Am J Pathol  2009  175(6):2657-67  PubMed ID: 19875502   DOI: 10.2353/ajpath.2009.090202
18123  Moriya F, Ogasawara S, Basaki Y, Akiba J, Kojiro S, Fukahori S, Ishizaki H, Nishida N, Matsuoka K, Kojiro M, Kuwano M, Yano H.  Growth inhibitory effects of pegylated IFN-alpha2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo  Int J Oncol  2008  33(4):647-55  PubMed ID: 18813777   DOI: 10.1016/j.ijrobp.2008.06.320
12791  Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.  Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity  Biol Pharm Bull  2008  31(10):1933-7  PubMed ID: 18827358   DOI: 10.1248/bpb.31.1933
18947  Senda M, Ito A, Tsuchida A, Hagiwara T, Kaneda T, Nakamura Y, Kasama K, Kiso M, Yoshikawa K, Katagiri Y, Ono Y, Ogiso M, Urano T, Furukawa K, Oshima S, Furukawa K.  Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers  Biochem J  2007  402(3):459-70  PubMed ID: 17123352   DOI: 10.1042/BJ20061118
3396  Yamada, Daisuke, Kikuchi, Shinji, Williams, Yuko N, Sakurai-Yageta, Mika, Masuda, Mari, Maruyama, Tomoko, Tomita, Kyoichi, Gutmann, David H, Kakizoe, Tadao, Kitamura, Tadaichi, Kanai, Yae, Murakami, Yoshinori  Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.  Int J Cancer  2006  118:916-23  PubMed ID: 16152585   DOI: 10.1002/ijc.21450
5012  Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.  Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.  Hum Mol Genet  2006  15(6):821-30  PubMed ID: 16439445   DOI: 10.1093/hmg/ddl001
14006  Hirota E, Yan L, Tsunoda T, Ashida S, Fujime M, Shuin T, Miki T, Nakamura Y, Katagiri T.  Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma  Int J Oncol  2006  29(4):799-827.  PubMed ID: 16964377  
3164  Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto  The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.  Biochemistry  2005  44:6343-9  PubMed ID: 15835923   DOI: 10.1021/bi047606a
3344  Chen, Qinzhong, Shinohara, Nobuo, Abe, Takashige, Watanabe, Takafumi, Nonomura, Katsuya, Koyanagi, Tomohiko  Significance of COX-2 expression in human renal cell carcinoma cell lines.  Int J Cancer  2004  108:825-32  PubMed ID: 14712483   DOI: 10.1002/ijc.11646
18945  Chen Q, Shinohara N, Abe T, Harabayashi T, Nonomura K.  Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line  J Urol  2004  172(6 Pt 1):2153-7  PubMed ID: 15538221   DOI: 10.1097/01.ju.0000143440.08760.3a
2661  Kasuya, Yutaka, Hosaka, Yoshio, Matsushima, Hisashi, Goto, Toshitaka, Kitamura, Tadaichi, Okuyama, Akira  Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1.  Int J Urol  2003  10:323-31  PubMed ID: 12757604   DOI: 10.1046/j.1442-2042.2003.00626.x
2548  Sudo, Tatsuhiko, Yagasaki, Yuki, Hama, Hiroshi, Watanabe, Naoko, Osada, Hiroyuki  Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  Biochem Biophys Res Commun  2002  291:838-43  PubMed ID: 11866441   DOI: 10.1006/bbrc.2002.6529
2561  Kasuya Y, Hosaka Y, Matsushima H, Goto T, Kitamura T  Differences in cell kinetic changes among renal cancer cell lines treated with interferon-alpha.  Int J Urol  2001  8:449-54  PubMed ID: 11555012   DOI: 10.1046/j.1442-2042.2001.00346.x
2441  Tsurushima H, Liu SQ, Tuboi K, Matsumura A, Yoshii Y, Nose T, Saijo K, Ohno T.  Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes  Jpn J Cancer Res  1999  90(5):536-45  PubMed ID: 10391094   DOI: 10.1111/j.1349-7006.1999.tb00781.x
2318  Liu SQ, Kawai K, Shiraiwa H, Hayashi H, Akaza H, Hashizaki K, Shiba R, Saijo K, Ohno T.  High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail.  Jpn J Cancer Res  1998  89(11):1195-201  PubMed ID: 9914789   DOI: 10.1111/j.1349-7006.1998.tb00515.x
2385  Shinohara N, Ogiso Y, Tanaka M, Sazawa A, Harabayashi T, Koyanagi T.  The significance of Ras guanine nucleotide exchange factor, son of sevenless protein, in renal cell carcinoma cell lines  J Urol  1997  158(3 Pt 1):908-11  PubMed ID: 9258117   DOI: 10.1097/00005392-199709000-00070
2061  Sugimoto H, Nishino H  [Effect of recombinant human basic fibroblast growth factor (bFGF) on the growth of human tumor cell lines]  Hum Cell  1996  9:129-40  PubMed ID: 9183641  
17992  Inoue M, Yano H, Kojiro M.  Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma  Int J Oncol  1996  9(1):49-56  PubMed ID: 21541480   DOI: 10.3892/ijo.9.1.49
2122  Liu, S Q, Shiraiwa H, Kawai K, Hayashi H, Akaza H, Kim, B S, Oki A, Nishida M, Kubo T, Hashizaki K, Saijo K, Ohno T  Tumor-Specific Autologous Cytotoxic T Lymphocytes from Tissue Sections  Nat Med  1996  2(12):1283  PubMed ID: 8946818   DOI: 10.1038/nm1296-1283
17231  Ogose A, Motoyama T, Hotta T, Watanabe H.  Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells  Pathol Int  1996  46(1):9-14  PubMed ID: 10846544   DOI: 10.1111/j.1440-1827.1996.tb03527.x
1902  Shu Qin Liu, Kaoru Saijo, Makoto Kodama, Tadao Ohno  Intelligent matrices for tumor-specific cytotoxic T lymphocytes  Materials Science and Engineering: C  1994  2:61-65    DOI: 10.1016/0928-4931(94)90030-2



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