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Cell No. : Cell Name
RCB0702 : WI-38  update : 2022/08/24
CommentThe most famous normal human fibroblast. Obtained directly from L. Hayflick. Younger PDL than RCB704 at time of deposit.
Comment from the depositor
Terms and conditionsNo restriction, but the user needs depositor's approval to use for any commercial purpose.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Hayflick, Leonard
Originator Hayflick, Leonard
Year of deposit 1991
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 3 months gestation
Tissue embryo/fetus, lung
Classification normal
History overseas
Lifespan finite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_0579
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 44-92(50) : 44(1),45(3),46(41),47(3),90(1),92(1)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 20
User's Publication 63


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Reference
4807  Olshansky SJ1, Hayflick L2.  The Role of the WI-38 Cell Strain in Saving Lives and Reducing Morbidity.  AIMS Public Health  2017  4(2):127-138  PubMed ID: 29546209   DOI: 10.3934/publichealth.2017.2.127
4808  Meredith Wadman  In 1962, Leonard Hayflick created a cell strain from an aborted fetus. More than 50 years later, WI-38 remains a crucial, but controversial, source of cells.  Nature  2013  2013-06-27    DOI: 10.1038/498422a
4806  Hayflick L.  Paying for tissue: the case of WI-38.  Science  2012  37(6100):1292  PubMed ID: 22984048   DOI: 10.1126/science.337.6100.1292-a
4805  Hayflick L.  A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy.  Exp Gerontol  1998  33(1-2):191-207  PubMed ID: 9467730   DOI: 10.1016/s0531-5565(97)00115-0
4804  Hayflick L.  Antecedents of cell aging research.  Exp Gerontol  1989  24(5-6):355-65  PubMed ID: 2698813   DOI: 10.1016/0531-5565(89)90043-0
4803  Hayflick L.  The cell biology of aging.  Clin Geriatr Med  1985  1(1):15-27  PubMed ID: 3913498  
4802  Matsumura T, Pfendt EA, Zerrudo Z, Hayflick L.  Senescent human diploid cells (WI-38). Attempted induction of proliferation by infection with SV40 and by fusion with irradiated continuous cell lines.  Exp Cell Res  1980  125(2):453-7  PubMed ID: 6243571   DOI: 10.1016/0014-4827(80)90139-1
4800  Matsumura T, Pfendt EA, Hayflick L.  DNA synthesis in the human diploid cell strain WI-38 during in vitro aging: an autoradiography study.  J Gerontol  1979  34(3):323-7  PubMed ID: 429764   DOI: 10.1093/geronj/34.3.323
4801  Matsumura T, Zerrudo Z, Hayflick L.  Senescent human diploid cells in culture: survival, DNA synthesis and morphology.  J Gerontol  1979  34(3):328-34  PubMed ID: 429765   DOI: 10.1093/geronj/34.3.328
4799  Razin S, Pfendt EA, Matsumura T, Hayflick L.  Comparison by autoradiography of macromolecular biosynthesis in "young" and "old" human diploid fibroblast cultures. A brief note.  Mech Ageing Dev  1977  6(5):379-84  PubMed ID: 895211   DOI: 10.1016/0047-6374(77)90039-2
4797  Masover GK, Namba M, Hayflick L.  Cytotoxic effect of a T-strain mycoplasma (Ureaplasma urealyticum) on cultured normal human cells (wi-38).  Exp Cell Res  1976  99(2):363-74  PubMed ID: 1269532   DOI: 10.1016/0014-4827(76)90594-2
4798  Bradley MO, Hayflick L, Schimke RT.  Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.  J Biol Chem  1976  251(12):3521-9  PubMed ID: 931997  
4796  Wright WE, Hayflick L.  The regulation of cellular aging by nuclear events in cultured normal human fibroblasts (WI-38).  Adv Exp Med Biol  1975  61:39-55  PubMed ID: 1180169   DOI: 10.1007/978-1-4615-9032-3_3
4794  Tomkins GA, Stanbridge EJ, Hayflick L.  Viral probes of aging in the human diploid cell strain WI-38.  Proc Soc Exp Biol Med  1974  146(2):385-90  PubMed ID: 4365308   DOI: 10.3181/00379727-146-38110
4795  Smith JR, Hayflick L.  Variation in the life-span of clones derived from human diploid cell strains.  J Cell Biol  1974  62(1):48-53  PubMed ID: 4407044   DOI: 10.1083/jcb.62.1.48
4793  Wright WE, Hayflick L.  Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B.  Exp Cell Res  1972  74(1):187-94  PubMed ID: 4342183   DOI: 10.1016/0014-4827(72)90496-x
4792  Stanbridge E, Onen M, Perkins FT, Hayflick L.  Karyological and morphological characteristics of human diploid cell strain WI-38 infected with mycoplasmas.  Exp Cell Res  1969  57(2):397-410  PubMed ID: 5347639   DOI: 10.1016/0014-4827(69)90166-9
375  HAYFLICK L.  THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.  Exp Cell Res  1965  37:614-36  PubMed ID: 14315085   DOI: 10.1016/0014-4827(65)90211-9
454  HAYFLICK L, PLOTKIN SA, NORTON TW, KOPROWSKI H.  Preparation of poliovirus vaccines in a human fetal diploid cell strain.  Am J Hyg  1962  75:240-58  PubMed ID: 13905660  
453  HAYFLICK L, MOORHEAD PS.  The serial cultivation of human diploid cell strains.  Exp Cell Res  1961  25:585-621  PubMed ID: 13905658   DOI: 10.1016/0014-4827(61)90192-6

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User's Publication
20410  Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.  Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.  Radiat Res  2022    PubMed ID: 34634126   DOI: 10.1667/RADE-21-00112.1
20581  Togami K, Ogasawara A, Irie S, Iwata K, Yamaguchi K, Tada H, Chono S.  Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis.  Eur J Pharm Biopharm  2022    PubMed ID: 35183716   DOI: 10.1016/j.ejpb.2022.02.009
20891  Matsuya Y, Kai T, Parisi A, Yoshii Y, Sato T.  Application of a simple DNA damage model developed for electrons to proton irradiation.  Phys Med Biol  2022    PubMed ID: 36228611   DOI: 10.1088/1361-6560/ac9a20
20040  Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A.  The ubiquinone synthesis pathway is a promising drug target for Chagas disease.  PLoS One  2021  16(2):e0243855  PubMed ID: 33539347   DOI: 10.1371/journal.pone.0243855
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12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206   DOI: 10.3727/096504019X15736439848765
13134  Wang J, Kobayashi A, Ohsawa D, Oikawa M, Konishi T.  Cytoplasmic Radiation Induced Radio-Adaptive Response in Human Lung Fibroblast WI-38 Cells.  Radiat Res  2020    PubMed ID: 32942306   DOI: 10.1667/RR15575.1
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095   DOI: 10.1080/03639045.2020.1825473
13767  Togami K, Yamaguchi K, Tada H, Chono S.  Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis  Pharmazie  2020  75(8):371-374  PubMed ID: 32758335   DOI: 10.1691/ph.2020.0048
13944  Akaike Y, Chibazakura T.  Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells  Cell Cycle  2020  19(1):84-96  PubMed ID: 31760882   DOI: 10.1080/15384101.2019.1693119
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11392  Nagano T, Yamao S, Terachi A, Yarimizu H, Itoh H, Katasho R, Kawai K, Nakashima A, Iwasaki T, Kikkawa U, Kamada S.  d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species.  Life Sci Alliance  2019    PubMed ID: 30659069   DOI: 10.26508/lsa.201800045
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060   DOI: 10.1093/rpd/ncy249
11877  Nozaki S, Nakatani Y, Mawatari A, Shibata N, Hume WE, Hayashinaka E, Wada Y, Doi H, Watanabe Y.  18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation.  Sci Rep  2019    PubMed ID: 31673030   DOI: 10.1038/s41598-019-52270-x
12605  Nakashima T, Nagano S, Setoguchi T, Sasaki H, Saitoh Y, Maeda S, Komiya S, Taniguchi N.  Tranilast enhances the effect of anticancer agents in osteosarcoma  Oncol Rep  2019  42(1):176-188  PubMed ID: 31059083   DOI: 10.3892/or.2019.7150
12606  Wang J, Konishi T.  Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks  Cancer Sci  2019  110(2):686-696  PubMed ID: 30561156   DOI: 10.1111/cas.13916
10430  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.  Cytotechnology  2018  70(3):899-912  PubMed ID: 28710570   DOI: 10.1007/s10616-017-0116-1
4449  Teruaki Konishi, Alisa Kobayashi, Tengku Ahbrizal Farizal Tengku Ahmad, Jun Wang  Enhanced DNA double strand break repair triggered by microbeam irradiation induced cytoplasmic damage  Journal of Radiation and Cancer Research  2018  9,183-189    DOI: 10.4103/jrcr.jrcr_21_18
4373  Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K.  Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.  Sci Rep  2018  8(1):8438  PubMed ID: 29855511   DOI: 10.1038/s41598-018-26860-0
10126  Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557   DOI: 10.1007/s11745-017-4236-3
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138   DOI: 10.1016/j.mrfmmm.2017.06.006
10037  Taku Chibazakura, Yuichi Asano  Defective Interaction Between p27 and Cyclin A-CDK Complex in Certain Human Cancer Cell Lines Revealed by Split YFP Assay in Living Cells  Biosci Biotechnol Biochem  2017  81(12):2360-2366  PubMed ID: 29098944   DOI: 10.1080/09168451.2017.1391686
14247  Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K, Murayama T.  Antifibrotic effects of cyclosporine A on TGF-β1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α  FASEB J  2017  31(8):3359-3371  PubMed ID: 28446589   DOI: 10.1096/fj.201601357R
6039  Badr H, Kozai D, Sakaguchi R, Numata T, Mori Y.  Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.  Front Pharmacol  2016  7:19  PubMed ID: 26903865   DOI: 10.3389/fphar.2016.00019
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853   DOI: 10.1186/s12885-016-2585-6
10168  Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro Ogura, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa, Tohru Tanaka  5-Aminolevulinic Acid Enhances Cell Death Under Thermal Stress in Certain Cancer Cell Lines  Biosci Biotechnol Biochem   2015  79(3):422-31  PubMed ID: 25346276   DOI: 10.1080/09168451.2014.975186
13693  Tsujiura M, Komatsu S, Ichikawa D, Shiozaki A, Konishi H, Takeshita H, Moriumura R, Nagata H, Kawaguchi T, Hirajima S, Arita T, Fujiwara H, Okamoto K, Otsuji E.  Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer  Gastric Cancer  2015  18(2):271-9  PubMed ID: 24626859   DOI: 10.1007/s10120-014-0363-1
14963  Togami K, Miyao A, Miyakoshi K, Kanehira Y, Tada H, Chono S.  Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.  Biol Pharm Bull  2015  38(2):270-6  PubMed ID: 25747986   DOI: 10.1248/bpb.b14-00659
15209  Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K.  Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells  Org Biomol Chem  2015  13(42):10556-68  PubMed ID: 26340595   DOI: 10.1039/c5ob01634g
15430  Atsumi Y, Minakawa Y, Ono M, Dobashi S, Shinohe K, Shinohara A, Takeda S, Takagi M, Takamatsu N, Nakagama H, Teraoka H, Yoshioka K.  ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation  Cell Rep  2015  13(12):2728-40  PubMed ID: 26711340   DOI: 10.1016/j.celrep.2015.11.054
10984  Hiroshi Kuwata, Makiko Yoshimura, Yuka Sasaki, Emiko Yoda, Yoshihito Nakatani, Ichiro Kudo, Shuntaro Hara  Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts  Biochim Biophys Acta  2014  1841(1):44-53  PubMed ID: 24095834   DOI: 10.1016/j.bbalip.2013.09.015
15986  Hane H, Muro Y, Watanabe K, Ogawa Y, Sugiura K, Akiyama M.  Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease  Clin Chim Acta  2014  431:9-14  PubMed ID: 24508626   DOI: 10.1016/j.cca.2014.01.005
15992  Segawa S, Goto D, Horikoshi M, Kondo Y, Umeda N, Hagiwara S, Yokosawa M, Hirota T, Miki H, Tsuboi H, Ogishima H, Suzuki T, Matsumoto I, Sumida T.  Involvement of CD161+ Vδ1+ γδ T cells in systemic sclerosis: association with interstitial pneumonia  Rheumatology (Oxford)  2014  53(12):2259-69  PubMed ID: 24972843   DOI: 10.1093/rheumatology/keu246
6577  Gu Lx, Johno H, Nakajima S, Yoshitomi T, Takahashi S, Kitamura M.  Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.  Toxicol Sci  2013  134(2):345-54  PubMed ID: 23690541   DOI: 10.1093/toxsci/kft111
15674  Wakasaya T, Yoshino H, Fukushi Y, Yoshizawa A, Kashiwakura I.  A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line  Int J Oncol  2013  42(4):1205-11.  PubMed ID: 23381730   DOI: 10.3892/ijo.2013.1804
15675  Nakano H, Saito N, Parker L, Tada Y, Abe M, Tsuganezawa K, Yokoyama S, Tanaka A, Kojima H, Okabe T, Nagano T.  Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound  J Med Chem  2012  55(11):5151-64  PubMed ID: 22540945   DOI: 10.1021/jm3001289
7643  Morimura R, Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Nagata H, Konishi H, Shiozaki A, Ikoma H, Okamoto K, Ochiai T, Taniguchi H, Otsuji E.  Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer.  Br. J. Cancer  2011  105:1733-40  PubMed ID: 22045190   DOI: 10.1038/bjc.2011.453
7650  Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K.  miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.  Blood  2011  118:6881-92  PubMed ID: 22042699   DOI: 10.1182/blood-2011-05-354654
12662  Takahashi N, Mori Y.  TRP Channels as Sensors and Signal Integrators of Redox Status Changes  Front Pharmacol  2011  2:58  PubMed ID: 22016736   DOI: 10.3389/fphar.2011.00058
16541  Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T.  Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells  Int J Oncol  2010  37(4):869-77  PubMed ID: 20811709   DOI: 10.3892/ijo_00000738
4045  Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y.  TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity.  J Neuroimmunol  2009  207(1-2):66-74  PubMed ID: 19135264   DOI: 10.1016/j.jneuroim.2008.12.001
15535  Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K.  Modulation of microRNA processing by p53  Nature  2009  460(7254):529-33  PubMed ID: 19626115   DOI: 10.1038/nature08199
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
8846  Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.  Br. J. Pharmacol.  2007  150:209-19  PubMed ID: 17160010   DOI: 10.1038/sj.bjp.0706972
3579  Sudo K, Kanno M, Miharada K, Ogawa S, Hiroyama T, Saijo K, Nakamura Y.  Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations.  Stem Cells  2007  25(7):1610-7  PubMed ID: 17395773   DOI: 10.1634/stemcells.2006-0504
3565  Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N.  Dynamic regulation of p53 subnuclear localization and senescence by MORC3.  Mol Biol Cell  2007  18(5):1701-9  PubMed ID: 17332504   DOI: 10.1091/mbc.e06-08-0747
5896  Shimada H, Kuboshima M, Shiratori T, Nabeya Y, Takeuchi A, Takagi H, Nomura F, Takiguchi M, Ochiai T, Hiwasa T.  Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.  Int J Oncol.   2007  30(1):97-103  PubMed ID: 17143517  
6297  Yamada K, Moriyama H, Yasuda H, Hara K, Maniwa Y, Hamada H, Yokono K, Nagata M.  Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity.  Hum Gene Ther  2007  18(5):389-400  PubMed ID: 17518613   DOI: 10.1089/hum.2006.126
15596  Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M.  Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1  Am J Respir Cell Mol Biol  2007  37(4):395-404  PubMed ID: 17641298   DOI: 10.1165/rcmb.2007-0065OC
2885  Seo E, Abei M, Wakayama M, Fukuda K, Ugai H, Murata T, Todoroki T, Matsuzaki Y, Tanaka N, Hamada H, Yokoyama KK.  Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration.  Cancer Res  2005  65(2):546-52  PubMed ID: 15695398  
3228  Wu CA, Tsujita M, Hayashi M, Yokoyama S.  Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation.  J Biol Chem  2004  279(29):30168-74  PubMed ID: 15140889   DOI: 10.1074/jbc.M403765200
3231  Arakawa R, Hayashi M, Remaley AT, Brewer BH, Yamauchi Y, Yokoyama S.  Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides.  J Biol Chem  2004  279(8):6217-20  PubMed ID: 14701850   DOI: 10.1074/jbc.C300553200
2978  Takayama Y, Takahashi H, Mizumachi K, Takezawa T.  Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts.  J Biol Chem  2003  278(24):22112-8  PubMed ID: 12672816   DOI: 10.1074/jbc.M300894200
3227  Yamauchi Y, Hayashi M, Abe-Dohmae S, Yokoyama S.  Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly.  J Biol Chem  2003  278(48):47890-7  PubMed ID: 12952980   DOI: 10.1074/jbc.M306258200
2977  Takayama Y, Mizumachi K, Takezawa T.  The bovine lactoferrin region responsible for promoting the collagen gel contractile activity of human fibroblasts.  Biochem Biophys Res Commun  2002  299(5):813-7  PubMed ID: 12470651   DOI: 10.1016/s0006-291x(02)02748-1
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