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Cell No. : Cell Name
RCB0702 : WI-38  update : 2024/09/11
CommentThe most famous normal human fibroblast. Obtained directly from L. Hayflick. Younger PDL than RCB704 at time of deposit.
Comment from the depositor
Terms and conditionsNo restriction, but the user needs depositor's approval to use for any commercial purpose.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Hayflick, Leonard
Originator Hayflick, Leonard
Year of deposit 1991
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 3 months gestation
Tissue embryo/fetus, lung
Classification normal
History overseas
Lifespan finite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_0579
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 44-92(50) : 44(1),45(3),46(41),47(3),90(1),92(1)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 20
User's Publication 81


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Reference
4807  Olshansky SJ1, Hayflick L2.  The Role of the WI-38 Cell Strain in Saving Lives and Reducing Morbidity.  AIMS Public Health  2017  4(2):127-138  PubMed ID: 29546209   DOI: 10.3934/publichealth.2017.2.127
4808  Meredith Wadman  Medical research: cell division  Nature  2013  2013-06-27  PubMed ID: 23803825   DOI: 10.1038/498422a
4806  Hayflick L.  Paying for tissue: the case of WI-38.  Science  2012  37(6100):1292  PubMed ID: 22984048   DOI: 10.1126/science.337.6100.1292-a
4805  Hayflick L.  A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy.  Exp Gerontol  1998  33(1-2):191-207  PubMed ID: 9467730   DOI: 10.1016/s0531-5565(97)00115-0
4804  Hayflick L.  Antecedents of cell aging research.  Exp Gerontol  1989  24(5-6):355-65  PubMed ID: 2698813   DOI: 10.1016/0531-5565(89)90043-0
4803  Hayflick L.  The cell biology of aging.  Clin Geriatr Med  1985  1(1):15-27  PubMed ID: 3913498  
4802  Matsumura T, Pfendt EA, Zerrudo Z, Hayflick L.  Senescent human diploid cells (WI-38). Attempted induction of proliferation by infection with SV40 and by fusion with irradiated continuous cell lines.  Exp Cell Res  1980  125(2):453-7  PubMed ID: 6243571   DOI: 10.1016/0014-4827(80)90139-1
4800  Matsumura T, Pfendt EA, Hayflick L.  DNA synthesis in the human diploid cell strain WI-38 during in vitro aging: an autoradiography study.  J Gerontol  1979  34(3):323-7  PubMed ID: 429764   DOI: 10.1093/geronj/34.3.323
4801  Matsumura T, Zerrudo Z, Hayflick L.  Senescent human diploid cells in culture: survival, DNA synthesis and morphology.  J Gerontol  1979  34(3):328-34  PubMed ID: 429765   DOI: 10.1093/geronj/34.3.328
4799  Razin S, Pfendt EA, Matsumura T, Hayflick L.  Comparison by autoradiography of macromolecular biosynthesis in "young" and "old" human diploid fibroblast cultures. A brief note.  Mech Ageing Dev  1977  6(5):379-84  PubMed ID: 895211   DOI: 10.1016/0047-6374(77)90039-2
4797  Masover GK, Namba M, Hayflick L.  Cytotoxic effect of a T-strain mycoplasma (Ureaplasma urealyticum) on cultured normal human cells (wi-38).  Exp Cell Res  1976  99(2):363-74  PubMed ID: 1269532   DOI: 10.1016/0014-4827(76)90594-2
4798  Bradley MO, Hayflick L, Schimke RT.  Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.  J Biol Chem  1976  251(12):3521-9  PubMed ID: 931997  
4796  Wright WE, Hayflick L.  The regulation of cellular aging by nuclear events in cultured normal human fibroblasts (WI-38).  Adv Exp Med Biol  1975  61:39-55  PubMed ID: 1180169   DOI: 10.1007/978-1-4615-9032-3_3
4794  Tomkins GA, Stanbridge EJ, Hayflick L.  Viral probes of aging in the human diploid cell strain WI-38.  Proc Soc Exp Biol Med  1974  146(2):385-90  PubMed ID: 4365308   DOI: 10.3181/00379727-146-38110
4795  Smith JR, Hayflick L.  Variation in the life-span of clones derived from human diploid cell strains.  J Cell Biol  1974  62(1):48-53  PubMed ID: 4407044   DOI: 10.1083/jcb.62.1.48
4793  Wright WE, Hayflick L.  Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B.  Exp Cell Res  1972  74(1):187-94  PubMed ID: 4342183   DOI: 10.1016/0014-4827(72)90496-x
4792  Stanbridge E, Onen M, Perkins FT, Hayflick L.  Karyological and morphological characteristics of human diploid cell strain WI-38 infected with mycoplasmas.  Exp Cell Res  1969  57(2):397-410  PubMed ID: 5347639   DOI: 10.1016/0014-4827(69)90166-9
375  HAYFLICK L.  THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.  Exp Cell Res  1965  37:614-36  PubMed ID: 14315085   DOI: 10.1016/0014-4827(65)90211-9
454  HAYFLICK L, PLOTKIN SA, NORTON TW, KOPROWSKI H.  Preparation of poliovirus vaccines in a human fetal diploid cell strain.  Am J Hyg  1962  75:240-58  PubMed ID: 13905660   DOI: 10.1093/oxfordjournals.aje.a120247
453  HAYFLICK L, MOORHEAD PS.  The serial cultivation of human diploid cell strains.  Exp Cell Res  1961  25:585-621  PubMed ID: 13905658   DOI: 10.1016/0014-4827(61)90192-6

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User's Publication
21806  Suzuki M, Kobayashi H, Hara D, Hanaoka H.  Elimination of radiation-induced senescent cancer cells and stromal cells in vitro by near-infrared photoimmunotherapy.  Cancer Med  2024  13(12):e7381  PubMed ID: 38888415   DOI: 10.1002/cam4.7381
21833  Hata M, Kadoya Y, Ueno J, Taki M, Kodera M.  Dicopper Complexes of p-Cresol-2,6-bis(amide-tether-dpa4-X) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups.  Inorg Chem  2024    PubMed ID: 39011904   DOI: 10.1021/acs.inorgchem.4c01072
21962  Okamoto Y, Kitakaze K, Takenouchi Y, Matsui R, Koga D, Miyashima R, Ishimaru H, Tsuboi K.  GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.  Biochim Biophys Acta Mol Cell Res  2024  1871(7):119798  PubMed ID: 39047914   DOI: 10.1016/j.bbamcr.2024.119798
22013  Takahashi K, Tanaka T, Ishihara A, Ohta T.  Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity.  Discov Oncol  2024  15(1):177  PubMed ID: 38769217   DOI: 10.1007/s12672-024-01041-w
17818  Wang J, Oikawa M, Konishi T.  Stimulation of Nuclear Factor (Erythroid-Derived 2)-like 2 Signaling by Nucleus Targeted Irradiation with Proton Microbeam  Biology (Basel)  2023  12(3):419  PubMed ID: 36979111   DOI: 10.3390/biology12030419
19763  Usukhbayar N, Uesugi S, Kimura KI.  3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines  Biosci Biotechnol Biochem  2023  87(11):1336-1344  PubMed ID: 37604790   DOI: 10.1093/bbb/zbad117
19885  Sofyana NT, Refli R, Takahashi M, Sakamoto K.  Oxygen nanobubble water affects wound healing of fibroblast WI-38 cells  Biosci Biotechnol Biochem  2023  87(6):620-626  PubMed ID: 37041088   DOI: 10.1093/bbb/zbad026
21338  Iriki T, Iio H, Yasuda S, Masuta S, Kato M, Kosako H, Hirayama S, Endo A, Ohtake F, Kamiya M, Urano Y, Saeki Y, Hamazaki J, Murata S.  Senescent cells form nuclear foci that contain the 26S proteasome.  Cell Rep  2023  112880  PubMed ID: 37541257   DOI: 10.1016/j.celrep.2023.112880
21379  Hata M, Ueno J, Hitomi Y, Kodera M.  Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.  ACS Omega  2023  8(31):28690-28701  PubMed ID: 37576680   DOI: 10.1021/acsomega.3c03387
21497  Koji Nakade, Satomi Tsukamoto, Kenichi Nakashima, Yuri An, Iori Sato, Jingyue Li, Yuzuno Shimoda, Yasuko Hemmi, Yoshihiro Miwa, Yohei Hayashi  Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system  Cell Reports Methods  2023    PubMed ID: 38086384   DOI: 10.1016/j.crmeth.2023.100662
21547  Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T.  Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions.  Biology (Basel)  2023  12(12)  PubMed ID: 38132311   DOI: 10.3390/biology12121485
17567  Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer  Cancer Sci  2022  113(6):1984-1998  PubMed ID: 35307915   DOI: 10.1111/cas.15342
20410  Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.  Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.  Radiat Res  2022    PubMed ID: 34634126   DOI: 10.1667/RADE-21-00112.1
20581  Togami K, Ogasawara A, Irie S, Iwata K, Yamaguchi K, Tada H, Chono S.  Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis.  Eur J Pharm Biopharm  2022    PubMed ID: 35183716   DOI: 10.1016/j.ejpb.2022.02.009
20891  Matsuya Y, Kai T, Parisi A, Yoshii Y, Sato T.  Application of a simple DNA damage model developed for electrons to proton irradiation.  Phys Med Biol  2022    PubMed ID: 36228611   DOI: 10.1088/1361-6560/ac9a20
20040  Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A.  The ubiquinone synthesis pathway is a promising drug target for Chagas disease.  PLoS One  2021  16(2):e0243855  PubMed ID: 33539347   DOI: 10.1371/journal.pone.0243855
16863  Takaki W, Konishi H, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Fujiwara H, Masuda K, Otsuji E.  Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2021  28(13):8508-8518  PubMed ID: 34185205   DOI: 10.1245/s10434-021-10089-9
9929  Keiko Tsuganezawa, Katsuhiko Sekimata, Yukari Nakagawa, Rei Utata, Kana Nakamura, Naoko Ogawa, Hiroo Koyama, Mikako Shirouzu, Takehiro Fukami, Kiyoshi Kita, AkikoTanaka  Identification of small molecule inhibitors of human COQ7  Bioorganic & Medicinal Chemistry  2020  28:115182  PubMed ID: 31753803   DOI: 10.1016/j.bmc.2019.115182
11894  Kurisawa N, Yukawa M, Koshino H, Onodera T, Toda T, Kimura KI.  Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells.  Bioorg. Med. Chem.  2020    PubMed ID: 31753800   DOI: 10.1016/j.bmc.2019.115154
12107  Matsubara D, Konishi H, Arita T, Shoda K, Fujita Y, Ogino S, Takao K, Nanishi K, Kosuga T, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.  Involvement of Intracellular and Extracellular High-Mobility Group Box-1 in the Progression of Esophageal Squamous Cell Carcinoma.  Ann. Surg. Oncol.  2020    PubMed ID: 32221734   DOI: 10.1245/s10434-020-08363-3
12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206   DOI: 10.3727/096504019X15736439848765
13134  Wang J, Kobayashi A, Ohsawa D, Oikawa M, Konishi T.  Cytoplasmic Radiation Induced Radio-Adaptive Response in Human Lung Fibroblast WI-38 Cells.  Radiat Res  2020    PubMed ID: 32942306   DOI: 10.1667/RR15575.1
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095   DOI: 10.1080/03639045.2020.1825473
13767  Togami K, Yamaguchi K, Tada H, Chono S.  Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis  Pharmazie  2020  75(8):371-374  PubMed ID: 32758335   DOI: 10.1691/ph.2020.0048
13944  Akaike Y, Chibazakura T.  Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells  Cell Cycle  2020  19(1):84-96  PubMed ID: 31760882   DOI: 10.1080/15384101.2019.1693119
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11392  Nagano T, Yamao S, Terachi A, Yarimizu H, Itoh H, Katasho R, Kawai K, Nakashima A, Iwasaki T, Kikkawa U, Kamada S.  d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species.  Life Sci Alliance  2019    PubMed ID: 30659069   DOI: 10.26508/lsa.201800045
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060   DOI: 10.1093/rpd/ncy249
11877  Nozaki S, Nakatani Y, Mawatari A, Shibata N, Hume WE, Hayashinaka E, Wada Y, Doi H, Watanabe Y.  18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation.  Sci Rep  2019    PubMed ID: 31673030   DOI: 10.1038/s41598-019-52270-x
12605  Nakashima T, Nagano S, Setoguchi T, Sasaki H, Saitoh Y, Maeda S, Komiya S, Taniguchi N.  Tranilast enhances the effect of anticancer agents in osteosarcoma  Oncol Rep  2019  42(1):176-188  PubMed ID: 31059083   DOI: 10.3892/or.2019.7150
12606  Wang J, Konishi T.  Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks  Cancer Sci  2019  110(2):686-696  PubMed ID: 30561156   DOI: 10.1111/cas.13916
10430  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.  Cytotechnology  2018  70(3):899-912  PubMed ID: 28710570   DOI: 10.1007/s10616-017-0116-1
4449  Teruaki Konishi, Alisa Kobayashi, Tengku Ahbrizal Farizal Tengku Ahmad, Jun Wang  Enhanced DNA double strand break repair triggered by microbeam irradiation induced cytoplasmic damage  Journal of Radiation and Cancer Research  2018  9,183-189    DOI: 10.4103/jrcr.jrcr_21_18
4373  Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K.  Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes.  Sci Rep  2018  8(1):8438  PubMed ID: 29855511   DOI: 10.1038/s41598-018-26860-0
10126  Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557   DOI: 10.1007/s11745-017-4236-3
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138   DOI: 10.1016/j.mrfmmm.2017.06.006
10037  Taku Chibazakura, Yuichi Asano  Defective Interaction Between p27 and Cyclin A-CDK Complex in Certain Human Cancer Cell Lines Revealed by Split YFP Assay in Living Cells  Biosci Biotechnol Biochem  2017  81(12):2360-2366  PubMed ID: 29098944   DOI: 10.1080/09168451.2017.1391686
14247  Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K, Murayama T.  Antifibrotic effects of cyclosporine A on TGF-β1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α  FASEB J  2017  31(8):3359-3371  PubMed ID: 28446589   DOI: 10.1096/fj.201601357R
6039  Badr H, Kozai D, Sakaguchi R, Numata T, Mori Y.  Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.  Front Pharmacol  2016  7:19  PubMed ID: 26903865   DOI: 10.3389/fphar.2016.00019
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853   DOI: 10.1186/s12885-016-2585-6
10168  Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro Ogura, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa, Tohru Tanaka  5-Aminolevulinic Acid Enhances Cell Death Under Thermal Stress in Certain Cancer Cell Lines  Biosci Biotechnol Biochem   2015  79(3):422-31  PubMed ID: 25346276   DOI: 10.1080/09168451.2014.975186
13693  Tsujiura M, Komatsu S, Ichikawa D, Shiozaki A, Konishi H, Takeshita H, Moriumura R, Nagata H, Kawaguchi T, Hirajima S, Arita T, Fujiwara H, Okamoto K, Otsuji E.  Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer  Gastric Cancer  2015  18(2):271-9  PubMed ID: 24626859   DOI: 10.1007/s10120-014-0363-1
14963  Togami K, Miyao A, Miyakoshi K, Kanehira Y, Tada H, Chono S.  Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.  Biol Pharm Bull  2015  38(2):270-6  PubMed ID: 25747986   DOI: 10.1248/bpb.b14-00659
15209  Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K.  Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells  Org Biomol Chem  2015  13(42):10556-68  PubMed ID: 26340595   DOI: 10.1039/c5ob01634g
15430  Atsumi Y, Minakawa Y, Ono M, Dobashi S, Shinohe K, Shinohara A, Takeda S, Takagi M, Takamatsu N, Nakagama H, Teraoka H, Yoshioka K.  ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation  Cell Rep  2015  13(12):2728-40  PubMed ID: 26711340   DOI: 10.1016/j.celrep.2015.11.054
18952  Yamashita K, Hagiya Y, Nakajima M, Ishizuka M, Tanaka T, Ogura S.  The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation  FEBS Open Bio  2014  4:347-52  PubMed ID: 24918048   DOI: 10.1016/j.fob.2014.03.010
19235  Kozai D, Kabasawa Y, Ebert M, Kiyonaka S, Firman, Otani Y, Numata T, Takahashi N, Mori Y, Ohwada T.  Transnitrosylation directs TRPA1 selectivity in N-nitrosamine activators  Mol Pharmacol  2014  85(1):175-85  PubMed ID: 24202912   DOI: 10.1124/mol.113.088864
10984  Hiroshi Kuwata, Makiko Yoshimura, Yuka Sasaki, Emiko Yoda, Yoshihito Nakatani, Ichiro Kudo, Shuntaro Hara  Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts  Biochim Biophys Acta  2014  1841(1):44-53  PubMed ID: 24095834   DOI: 10.1016/j.bbalip.2013.09.015
15986  Hane H, Muro Y, Watanabe K, Ogawa Y, Sugiura K, Akiyama M.  Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease  Clin Chim Acta  2014  431:9-14  PubMed ID: 24508626   DOI: 10.1016/j.cca.2014.01.005
15992  Segawa S, Goto D, Horikoshi M, Kondo Y, Umeda N, Hagiwara S, Yokosawa M, Hirota T, Miki H, Tsuboi H, Ogishima H, Suzuki T, Matsumoto I, Sumida T.  Involvement of CD161+ Vδ1+ γδ T cells in systemic sclerosis: association with interstitial pneumonia  Rheumatology (Oxford)  2014  53(12):2259-69  PubMed ID: 24972843   DOI: 10.1093/rheumatology/keu246
6577  Gu Lx, Johno H, Nakajima S, Yoshitomi T, Takahashi S, Kitamura M.  Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.  Toxicol Sci  2013  134(2):345-54  PubMed ID: 23690541   DOI: 10.1093/toxsci/kft111
15674  Wakasaya T, Yoshino H, Fukushi Y, Yoshizawa A, Kashiwakura I.  A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line  Int J Oncol  2013  42(4):1205-11.  PubMed ID: 23381730   DOI: 10.3892/ijo.2013.1804
15675  Nakano H, Saito N, Parker L, Tada Y, Abe M, Tsuganezawa K, Yokoyama S, Tanaka A, Kojima H, Okabe T, Nagano T.  Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound  J Med Chem  2012  55(11):5151-64  PubMed ID: 22540945   DOI: 10.1021/jm3001289
7643  Morimura R, Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Nagata H, Konishi H, Shiozaki A, Ikoma H, Okamoto K, Ochiai T, Taniguchi H, Otsuji E.  Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer.  Br. J. Cancer  2011  105:1733-40  PubMed ID: 22045190   DOI: 10.1038/bjc.2011.453
7650  Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K.  miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.  Blood  2011  118:6881-92  PubMed ID: 22042699   DOI: 10.1182/blood-2011-05-354654
18793  Kikuchi T, Uchiyama E, Ukiya M, Tabata K, Kimura Y, Suzuki T, Akihisa T.  Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos  J Nat Prod  2011  74(2):137-44  PubMed ID: 21250700   DOI: 10.1021/np100402b
18936  Wu D, Matsushita K, Matsubara H, Nomura F, Tomonaga T.  An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer  Int J Cancer  2011  128(5):1018-30  PubMed ID: 20473909   DOI: 10.1002/ijc.25419
12662  Takahashi N, Mori Y.  TRP Channels as Sensors and Signal Integrators of Redox Status Changes  Front Pharmacol  2011  2:58  PubMed ID: 22016736   DOI: 10.3389/fphar.2011.00058
16541  Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T.  Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells  Int J Oncol  2010  37(4):869-77  PubMed ID: 20811709   DOI: 10.3892/ijo_00000738
18469  Tsuna M, Kageyama S, Fukuoka J, Kitano H, Doki Y, Tezuka H, Yasuda H.  Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma  Anticancer Res  2009  29(7):2547-54  PubMed ID: 19596927  
4045  Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y.  TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity.  J Neuroimmunol  2009  207(1-2):66-74  PubMed ID: 19135264   DOI: 10.1016/j.jneuroim.2008.12.001
15535  Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K.  Modulation of microRNA processing by p53  Nature  2009  460(7254):529-33  PubMed ID: 19626115   DOI: 10.1038/nature08199
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
8846  Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.  Br. J. Pharmacol.  2007  150:209-19  PubMed ID: 17160010   DOI: 10.1038/sj.bjp.0706972
3579  Sudo K, Kanno M, Miharada K, Ogawa S, Hiroyama T, Saijo K, Nakamura Y.  Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations.  Stem Cells  2007  25(7):1610-7  PubMed ID: 17395773   DOI: 10.1634/stemcells.2006-0504
3565  Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N.  Dynamic regulation of p53 subnuclear localization and senescence by MORC3.  Mol Biol Cell  2007  18(5):1701-9  PubMed ID: 17332504   DOI: 10.1091/mbc.e06-08-0747
5896  Shimada H, Kuboshima M, Shiratori T, Nabeya Y, Takeuchi A, Takagi H, Nomura F, Takiguchi M, Ochiai T, Hiwasa T.  Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.  Int J Oncol.   2007  30(1):97-103  PubMed ID: 17143517  
6297  Yamada K, Moriyama H, Yasuda H, Hara K, Maniwa Y, Hamada H, Yokono K, Nagata M.  Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity.  Hum Gene Ther  2007  18(5):389-400  PubMed ID: 17518613   DOI: 10.1089/hum.2006.126
15596  Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M.  Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1  Am J Respir Cell Mol Biol  2007  37(4):395-404  PubMed ID: 17641298   DOI: 10.1165/rcmb.2007-0065OC
2885  Seo E, Abei M, Wakayama M, Fukuda K, Ugai H, Murata T, Todoroki T, Matsuzaki Y, Tanaka N, Hamada H, Yokoyama KK.  Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration.  Cancer Res  2005  65(2):546-52  PubMed ID: 15695398  
3228  Wu CA, Tsujita M, Hayashi M, Yokoyama S.  Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation.  J Biol Chem  2004  279(29):30168-74  PubMed ID: 15140889   DOI: 10.1074/jbc.M403765200
3231  Arakawa R, Hayashi M, Remaley AT, Brewer BH, Yamauchi Y, Yokoyama S.  Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides.  J Biol Chem  2004  279(8):6217-20  PubMed ID: 14701850   DOI: 10.1074/jbc.C300553200
2978  Takayama Y, Takahashi H, Mizumachi K, Takezawa T.  Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts.  J Biol Chem  2003  278(24):22112-8  PubMed ID: 12672816   DOI: 10.1074/jbc.M300894200
3227  Yamauchi Y, Hayashi M, Abe-Dohmae S, Yokoyama S.  Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly.  J Biol Chem  2003  278(48):47890-7  PubMed ID: 12952980   DOI: 10.1074/jbc.M306258200
2335  Fukuda K, Abei M, Ugai H, Seo E, Wakayama M, Murata T, Todoroki T, Tanaka N, Hamada H, Yokoyama KK.  E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer  Cancer Res  2003  63(15):4434-40  PubMed ID: 12907616  
2977  Takayama Y, Mizumachi K, Takezawa T.  The bovine lactoferrin region responsible for promoting the collagen gel contractile activity of human fibroblasts.  Biochem Biophys Res Commun  2002  299(5):813-7  PubMed ID: 12470651   DOI: 10.1016/s0006-291x(02)02748-1
2976  Takayama Y, Mizumachi K.  Effects of lactoferrin on collagen gel contractile activity and myosin light chain phosphorylation in human fibroblasts.  FEBS Lett  2001  508(1):111-6  PubMed ID: 11707279   DOI: 10.1016/s0014-5793(01)03041-1
6665  Takayama Y, Kitsunai K, Mizumachi K.  Factors in bovine colostrum that enhance the migration of human fibroblasts in type I collagen gels.  Biosci Biotechnol Biochem  2001  65(12):2776-9  PubMed ID: 11826977   DOI: 10.1271/bbb.65.2776
3978  Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I.  Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.  J Biol Chem  2000  275(42):32775-82  PubMed ID: 10922363   DOI: 10.1074/jbc.M003504200
5537  Takaoka AS, Yamada T, Gotoh M, Kanai Y, Imai K, Hirohashi S.  Cloning and characterization of the human beta4-integrin gene promoter and enhancers.  J Biol Chem  1998  273(50):33848-55  PubMed ID: 9837976   DOI: 10.1074/jbc.273.50.33848
2075  Takano M, Kondo J, Yayama K, Okamoto H.  Expression of low-molecular-weight kininogen mRNA in human fibroblast WI38 cells.  Jpn J Pharmacol  1996  71(4):341-3  PubMed ID: 8886933   DOI: 10.1254/jjp.71.341



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