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細胞番号 : 細胞名
RCB0658 : HHUA  update : 2024/05/30
細胞特性(Comment:英)Human cell line derived from endometrial cancer. HHUA (RCB0658) was derived from the same patient of SNG-M (JCRB0179), another “human endometrial cancer-derived cell line” distributed from another cell repository, JCRB cell bank in Japan (precise explanation).
細胞特性(日)ヒト子宮内膜癌由来細胞株。JCRB細胞バンクが頒布しているヒト子宮内膜癌由来細胞株のSNG-M (JCRB0179)細胞と同じ患者由来の細胞株である(参照)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Ishiwata, Isamu
樹立者 Ishiwata, Isamu
寄託日 1991
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Female
54 years
採取組織 endometrium
病名 Endometrial adenocarcinoma
細胞分類 cancer
初代培養日 1980
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_3866
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 HamF12 + 15% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
ウィルス(HIV) (-)
アイソザイム検査 LD, NP
染色体検査 40-92(50) : /44(2),45(7),46(29),47(6),53(1),92(2)
個体識別検査 OK
文献情報 Reference(英) 7件
Reference(日) 0件
利用者成果(英) 86件
利用者成果(日) 0件

257  Withanage GS, Murata H, Koyama T, Ishiwata I.  Agonistic and antagonistic effects of zearalenone, an etrogenic mycotoxin, on SKN, HHUA, and HepG2 human cancer cell lines  Vet Hum Toxicol  2001  43(1):6-10  PubMed ID: 11205083  
41  Ishiwata I, Ishiwata C, Nozawa S, Ishikawa H.  CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate  Asia Oceania J Obstet Gynaecol  1996  12(2):285-90  PubMed ID: 2429643   DOI: 10.1111/j.1447-0756.1986.tb00192.x
268  Wake N, Yamada H, Fujita H, Kato H, Ishiwata I.  Isolation of clones resistant to 6-thioguanine and G418 from HHUA endometrial carcinoma cells and their application to cell hybridization  Cancer Genet Cytogenet  1990  49(1):117-23  PubMed ID: 2397465   DOI: 10.1016/0165-4608(90)90172-7
42  Ishiwata I, Ishiwata C, Soma M, Naik DR, Hashimoto H, Sudo T, Ishikawa H.  Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation  Virchows Arch A Pathol Anat Histopathol  1990  417(6):473-6  PubMed ID: 2125385  
43  Yamada H, Wake N, Fujino T, Aihara T, Tanaka S, Tanaka T, Fujimoto S, Ishiwata I.  Somatic cell hybrids used in cytogenetic analysis of transformation mechanism of uterine endometrial cell  Nihon Sanka Fujinka Gakkai Zasshi  1989  41(2):122-8  PubMed ID: 2723479  
1521  Ishiwata I, Ishiwata C, Ishikawa H  Effects of estradiol-17 beta and progesterone on cell proliferation and differentiation of the human endometrial carcinoma cell line (HHUA) in vitro.  Asia Oceania J Obstet Gynaecol  1984  10:531-8  PubMed ID: 6532401   DOI: 10.1111/j.1447-0756.1984.tb00721.x
1519  Ishiwata I, Ishiwata C, Soma M, Arai J, Ishikawa H  Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesterone receptors.  Gynecol Oncol  1984  17:281-90  PubMed ID: 6706228   DOI: 10.1016/0090-8258(84)90212-9


21711  Yusuke Hanaki, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita  A new labdane-type diterpenoid from leaves of Vitex rotundifolia  Results in Chemistry  2024  7:101512    DOI: 10.1016/j.rechem.2024.101512
18065  Yusuke Hanaki, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita  Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex Rotundifolia as an Inhibitor of Phorbol Ester–Induced Downregulation of E-Cadherin in HHUA Endometrial Cells  BPB Reports  2023  6:103-107    DOI: 10.1248/bpbreports.6.3_103
18120  Bai H, Kawahara M, Takahashi M.  Identification of menaquinone-4 (vitamin K2) target genes in bovine endometrial epithelial cells in vitro  Theriogenology   2023  198:183-193  PubMed ID: 36592516   DOI: 10.1016/j.theriogenology.2022.12.033
17618  Dong P, Wang F, Taheri M, Xiong Y, Ihira K, Kobayashi N, Konno Y, Yue J, Watari H.  Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143  Front Oncol  2022  12:912935  PubMed ID: 35712514   DOI: 10.3389/fonc.2022.912935
20554  Sendo K, Seino M, Ohta T, Nagase S.  Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer.  Oncotarget  2022  13:224-236  PubMed ID: 35106124   DOI: 10.18632/oncotarget.28185
20722  Takao T, Masuda H, Kajitani T, Miki F, Miyazaki K, Yoshimasa Y, Katakura S, Tomisato S, Uchida S, Uchida H, Tanaka M, Maruyama T.  Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway.  Stem Cell Res Ther  2022  13(1):225  PubMed ID: 35659728   DOI: 10.1186/s13287-022-02888-y
17174  Hanaki Y, Miyoshi S, Sugiyama Y, Yanagita RC, Sato M.  12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial-mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases  Biosci Biotechnol Biochem  2022  86(10):1417-1422  PubMed ID: 35973688   DOI: 10.1093/bbb/zbac136
13789  Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe T, Soeda S, Fujimori K, Chiba H.  Aberrant claudin-6-adhesion signaling promotes endometrial cancer progression via estrogen receptor α  Mol Cancer Res  2021  molcanres.0835.2020  PubMed ID: 33727343   DOI: 10.1158/1541-7786.MCR-20-0835
14469  Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita  Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions  Fundamental Toxicological Sciences  2021  8:69-73    DOI: 10.2131/fts.8.69
20209  Dong P, Xiong Y, Konno Y, Ihira K, Kobayashi N, Yue J, Watari H.  Long non-coding RNA DLEU2 drives EMT and glycolysis in endometrial cancer through HK2 by competitively binding with miR-455 and by modulating the EZH2/miR-181a pathway.  J Exp Clin Cancer Res  2021  40(1):216  PubMed ID: 34174908   DOI: 10.1186/s13046-021-02018-1
13321  Kato M, Onoyama I, Kawakami M, Yoshida S, Kawamura K, Kodama K, Hori E, Cui L, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K.  Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia.  PLoS One  2020    PubMed ID: 33141854   DOI: 10.1371/journal.pone.0241482
13779  Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K.  Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer  Int J Cancer  2020  147(7):1987-1999  PubMed ID: 32159851   DOI: 10.1002/ijc.32965
10248  Osanai K, Kobayashi Y, Otsu M, Izawa T, Sakai K, Iwashita M.  Ramelteon, a selective MT1/MT2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells.  Hum. Cell  2017  30:209-215  PubMed ID: 28382516   DOI: 10.1007/s13577-017-0169-7
10315  Ando H, Miyamoto T, Kashima H, Higuchi S, Ida K, Mvunta DH, Shiozawa T.  Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6.  Horm Cancer  2017  8:257-267  PubMed ID: 28516379   DOI: 10.1007/s12672-017-0295-4
9667  Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, Miyasaka A, Kashiyama T, Arimoto T, Kuramoto H, Kawana K, Yano T, Osuga Y, Fujii T.  Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer.  Gynecol. Oncol.  2016  141:564-569  PubMed ID: 27079211   DOI: 10.1016/j.ygyno.2016.04.003
9687  Miyamoto T, Kashima H, Yamada Y, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa T.  Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.  PLoS ONE  2016  11:e0155220  PubMed ID: 27168162   DOI: 10.1371/journal.pone.0155220
12617  Nakayama K, Rahman MT, Rahman M, Nakamura K, Ishikawa M, Katagiri H, Sato E, Ishibashi T, Iida K, Ishikawa N, Kyo S.  CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas  Int J Oncol  2016  48(2):506-16  PubMed ID: 26647729   DOI: 10.3892/ijo.2015.3268
12648  Zou J, Hong L, Luo C, Li Z, Zhu Y, Huang T, Zhang Y, Yuan H, Hu Y, Wen T, Zhuang W, Cai B, Zhang X, Huang J, Cheng J.  Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway  Cancer Sci  2016  107(12):1806-1817  PubMed ID: 27636742   DOI: 10.1111/cas.13083
7200  Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K.  Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells.  Mol. Cell. Biol.  2015  35:4096-109  PubMed ID: 26391953   DOI: 10.1128/MCB.00678-15
7212  Asaka R, Miyamoto T, Yamada Y, Ando H, Mvunta DH, Kobara H, Shiozawa T.  Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.  Lab. Invest.  2015  95:1363-73  PubMed ID: 26367491   DOI: 10.1038/labinvest.2015.119
13788  Kajitani K, Honda K, Terada H, Yasui T, Sumi T, Koyama M, Ishiko O.  Human Papillomavirus E6 Knockdown Restores Adenovirus Mediated-estrogen Response Element Linked p53 Gene Transfer in HeLa Cells  Asian Pac J Cancer Prev  2015  16(18):8239-45  PubMed ID: 26745067   DOI: 10.7314/apjcp.2015.16.18.8239
18133  Dong P, Kaneuchi M, Xiong Y, Cao L, Cai M, Liu X, Guo SW, Ju J, Jia N, Konno Y, Watari H, Hosaka M, Sudo S, Sakuragi N.  Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer  Carcinogenesis  2014  35(4):760-8  PubMed ID: 24220291   DOI: 10.1093/carcin/bgt369
13796  Koyama N, Nishida Y, Ishii T, Yoshida T, Furukawa Y, Narahara H.  Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells  PLoS One  2014  9(3):e93050  PubMed ID: 24667764   DOI: 10.1371/journal.pone.0093050
13828  Miyasaka A, Oda K, Ikeda Y, Wada-Hiraike O, Kashiyama T, Enomoto A, Hosoya N, Koso T, Fukuda T, Inaba K, Sone K, Uehara Y, Kurikawa R, Nagasaka K, Matsumoto Y, Arimoto T, Nakagawa S, Kuramoto H, Miyagawa K, Yano T, Kawana K, Osuga Y, Fujii T.  Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells  BMC Cancer  2014  14:179  PubMed ID: 24625059   DOI: 10.1186/1471-2407-14-179
18134  Dong P, Karaayvaz M, Jia N, Kaneuchi M, Hamada J, Watari H, Sudo S, Ju J, Sakuragi N.  Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis  Oncogene  2013  32(27):3286-95  PubMed ID: 22847613   DOI: 10.1038/onc.2012.334
6463  Li H, Narahara H.  15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines.  Int J Mol Med.  2013  31(4):778-88  PubMed ID: 23403520   DOI: 10.3892/ijmm.2013.1268
13830  Ishii T, Kira N, Yoshida T, Narahara H.  Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells  Tumour Biol  2013  34(1):285-91  PubMed ID: 23150173   DOI: 10.1007/s13277-012-0549-2
7588  Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T.  Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells.  Histopathology  2012  60:826-37  PubMed ID: 22348356   DOI: 10.1111/j.1365-2559.2011.04158.x
13801  Tanaka T, Bai T, Toujima S, Utsunomiya T, Utsunomiya H, Yukawa K, Tanaka J.  Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells  Oncol Rep  2012  28(1):330-6  PubMed ID: 22552543   DOI: 10.3892/or.2012.1774
18135  Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J.  miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer  Cancer Res  2011  71(20):6450-62  PubMed ID: 21868754   DOI: 10.1158/0008-5472.CAN-11-0364
7708  Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N.  MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1.  Mol. Cancer  2011  10:99  PubMed ID: 21851624   DOI: 10.1186/1476-4598-10-99
7925  Miyamoto T, Kashima H, Suzuki A, Kikuchi N, Konishi I, Seki N, Shiozawa T.  Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance.  Hum. Pathol.  2011  42:1265-74  PubMed ID: 21334721   DOI: 10.1016/j.humpath.2010.07.027
13786  Honda K, Kajitani K, Nobeyama H, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida H, Matsumoto Y, Ichimura T, Yaui T, Sumi T, Ishiko O.  An upstream estrogen response element linked to exogenous p53 tumor suppressor gene expression differentiates effects of the codon 72 polymorphism  Asian Pac J Cancer Prev  2011  12(4):865-8  PubMed ID: 21790217  
13815  Tanaka T, Bai T, Yukawa K.  Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA  Eur J Gynaecol Oncol  2011  32(3):293-6  PubMed ID: 21797120  
13821  Tanaka T, Bai T, Utsunomiya H, Fukumoto T, Yukawa K.  STAT3 enhances intracellular Fas-mediated apoptotic signals in HHUA human endometrial epithelial cells  Mol Med Rep  2011  4(2):307-12  PubMed ID: 21468569   DOI: 10.3892/mmr.2011.424
8350  Fakhry H, Miyamoto T, Kashima H, Suzuki A, Ke H, Konishi I, Shiozawa T.  Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells.  Hum. Pathol.  2010  41:848-58  PubMed ID: 20178884   DOI: 10.1016/j.humpath.2009.11.012
8539  Suzuki A, Horiuchi A, Ashida T, Miyamoto T, Kashima H, Nikaido T, Konishi I, Shiozawa T.  Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin.  J. Cell. Mol. Med.  2010  14:2305-17  PubMed ID: 19583808   DOI: 10.1111/j.1582-4934.2009.00839.x
13793  Bai T, Tanaka T, Yukawa K.  Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells  Int J Oncol  2010  37(1):203-10  PubMed ID: 20514412   DOI: 10.3892/ijo_00000668
13794  Tanaka T, Bai T, Yukawa K.  Suppressed protein expression of the death-associated protein kinase enhances 5-fluorouracil-sensitivity but not etoposide-sensitivity in human endometrial adenocarcinoma cells  Oncol Rep  2010  24(5):1401-5  PubMed ID: 20878137   DOI: 10.3892/or_00000999
13827  Tanaka T, Bai T, Toujima S.  Establishment and characterization of monoclonal 5-fluorouracil-resistant cell lines derived from human endometrial adenocarcinoma  Int J Oncol   2010  37(3):731-6  PubMed ID: 20664942   DOI: 10.3892/ijo_00000722
13833  Takai N, Ueda T, Nishida M, Nasu K, Narahara H.  PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells  Int J Mol Med  2010  25(1):97-103  PubMed ID: 19956907  
13835  Takai N, Ueda T, Nishida M, Nasu K, Narahara H.  Synergistic anti-neoplastic effect of AG1478 in combination with cisplatin or paclitaxel on human endometrial and ovarian cancer cells  Mol Med Rep  2010  3(3):479-84  PubMed ID: 21472266   DOI: 10.3892/mmr_00000284
14016  Ishikawa M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Miyazaki K.  NAC1, a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma  Int J Oncol  2010  36(5):1097-103  PubMed ID: 20372782   DOI: 10.3892/ijo_00000591
14017  Tanaka T, Bai T, Yukawa K.  Death-associated protein kinase is essential for the survival of various types of uterine cancer cells  Int J Oncol  2010  37(4):1017-22  PubMed ID: 20811724   DOI: 10.3892/ijo_00000753
14018  Li H, Takai N, Yuge A, Furukawa Y, Tsuno A, Tsukamoto Y, Kong S, Moriyama M, Narahara H.  Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells  Cancer Lett  2010  297(2):198-206  PubMed ID: 20547442   DOI: 10.1016/j.canlet.2010.05.012
18119  Tanaka T, Umesaki N.  Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology  Int J Mol Med  2009  23(2):237-43  PubMed ID: 19148548  
18136  The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas  The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas  Br J Cancer  2009  101(1):145-8.  PubMed ID: 19491896   DOI: 10.1038/sj.bjc.6605109
13787  Ishibashi M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N, Miyazaki K.  Expression of a BTB/POZ protein, NAC1, is essential for the proliferation of normal cyclic endometrial glandular cells and is up-regulated by estrogen  Clin Cancer Res  2009  15(3):804-11  PubMed ID: 19188150   DOI: 10.1158/1078-0432.CCR-08-2134
13803  Takai N, Ueda T, Nasu K, Yamashita S, Toyofuku M, Narahara H.  Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas  Cancer Lett  2009  277(2):235-43  PubMed ID: 19168280   DOI: 10.1016/j.canlet.2008.12.018
13822  Tanaka T, Wang C, Umesaki N.  Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen  Int J Mol Med  2009  23(2):173-80  PubMed ID: 19148540  
8749  Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S.  Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction.  Endocr. Relat. Cancer  2008  15:451-63  PubMed ID: 18508998   DOI: 10.1677/ERC-07-0227
13798  Yoshizaki T, Enomoto T, Fujita M, Ueda Y, Miyatake T, Fujiwara K, Miyake T, Kimura T, Yoshino K, Kimura T.  Frequent inactivation of RUNX3 in endometrial carcinoma  Gynecol Oncol  2008  110(3):439-44  PubMed ID: 18572225   DOI: 10.1016/j.ygyno.2008.05.004
13823  Tanaka T, Umesaki N.  Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells  Int J Mol Med  2008  22(5):683-9.  PubMed ID: 18949391  
13829  Takai N, Ueda T, Nishida M, Nasu K, Narahara H.  Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells  Int J Mol Med  2008  21(5):637-43  PubMed ID: 18425357  
13834  Takai N, Ueda T, Nishida M, Nasu K, Narahara H.  K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells  Oncol Rep  2008  19(3):749-53  PubMed ID: 18288411  
18130  Feng YZ, Shiozawa T, Miyamoto T, Kashima H, Kurai M, Suzuki A, Ying-Song J, Konishi I.  Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells  Clin Cancer Res  2007  13(5):1389-98  PubMed ID: 17332280   DOI: 10.1158/1078-0432.CCR-06-1407
18131  Sato N, Ito K, Onogawa T, Akahira J, Unno M, Abe T, Niikura H, Yaegashi N.  Expression of organic cation transporter SLC22A16 in human endometria  Int J Gynecol Pathol  2007  26(1):53-60  PubMed ID: 17197897   DOI: 10.1097/01.pgp.0000225845.67245.b3
8772  Sugimoto T, Koizumi T, Sudo T, Yamaguchi S, Kojima A, Kumagai S, Nishimura R.  Correlative expression of cyclooxygenase-1 (Cox-1) and human epidermal growth factor receptor type-2 (Her-2) in endometrial cancer.  Kobe J Med Sci  2007  53:177-87  PubMed ID: 18204294  
13785  Zhi X, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H, Ishiko O.  Estradiol-17beta regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells  Int J Oncol  2007  31(6):1333-8  PubMed ID: 17982659  
18617  Takai N, Ueda T, Nishida M, Nasu K, Narahara H.  Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells  Anticancer Res  2006  26(2A):939-45  PubMed ID: 16619490  
13790  Abe H, Shibata MA, Otsuki Y.  Caspase cascade of Fas-mediated apoptosis in human normal endometrium and endometrial carcinoma cells  Mol Hum Reprod  2006  12(9):535-41  PubMed ID: 16870953   DOI: 10.1093/molehr/gah260
13820  Mochizuki T, Sakai K, Iwashita M.  Effects of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) on endometrial cancer (HHUA) cell apoptosis and EGF stimulated cell proliferation in vitro  Growth Horm IGF Res  2006  16(3):202-10  PubMed ID: 16844395   DOI: 10.1016/j.ghir.2006.05.002
3713  Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y.  Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.  Oncogene  2005  24(53):7946-52  PubMed ID: 16007117   DOI: 10.1038/sj.onc.1208910
11007  Tetsuji Tanaka , Tao Bai, Kazunori Yukawa, Naohiko Umesaki  Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells  Oncol Rep  2005  14(4):949-55  PubMed ID: 16142356  
13825  Tanaka T.  Effects of anti-endometriotic therapies on Fas-mediated endometrial epithelial apoptosis  Oncol Rep  2005  13(6):1235-9  PubMed ID: 15870948  
13795  Sugawara T, Nomura E, Fujimoto S.  Expression of enzyme associated with steroid hormone synthesis and local production of steroid hormone in endometrial carcinoma cells  J Endocrinol  2004  180(1):135-44  PubMed ID: 14709152   DOI: 10.1677/joe.0.1800135
13799  Enomoto M, Endo D, Kawashima S, Park MK.  Human type II GnRH receptor mediates effects of GnRH on cell proliferation  Zoolog Sci  2004  21(7):763-70  PubMed ID: 15277720   DOI: 10.2108/zsj.21.763
13800  Enomoto M, Seong JY, Kawashima S, Park MK.  Proliferation of TSU-Pr1, a human prostatic carcinoma cell line is stimulated by gonadotropin-releasing hormone  Life Sci . 2004 May 7;74(25):3141-52  2004  74(25):3141-52  PubMed ID: 15081579   DOI: 10.1016/j.lfs.2003.11.009
13826  Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N.  Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells  Oncol Rep  2004  11(3):661-5.  PubMed ID: 14767518  
14020  Tanaka T, Toujima S, Umesaki N.  Activin A inhibits growth-inhibitory signals by TGF-beta1 in differentiated human endometrial adenocarcinoma cells  Oncol Rep  2004  11(4):875-9  PubMed ID: 15010888  
14021  Tanaka T, Toujima S, Umesaki N.  Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells  Oncol Rep  2004  11(3):667-71  PubMed ID: 14767519  
13831  Unoki M, Nakamura Y.  Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity  FEBS Lett  2003  554(1-2):67-72  PubMed ID: 14596916   DOI: 10.1016/s0014-5793(03)01092-5
13832  Tanaka T, Umesaki N.  Fas antigen (CD95) mediates cell survival signals to regulate functional cellular subpopulations in normal human endometrial stromal cells  Int J Mol Med  2003  11(6):757-62  PubMed ID: 12736718  
14019  Tanaka T, Toujima S, Otani T, Minami S, Yamoto M, Umesaki N.  Expression and function of activin receptors in human endometrial adenocarcinoma cells  Int J Oncol  2003  23(3):657-63  PubMed ID: 12888901  
2758  Harada, Hideki, Saijo, Kaoru, Watanabe, Satoru, Tsuboi, Koji, Nose, Tadao, Ishiwata, Isamu, Ohno, Tadao  Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT.  Jpn J Cancer Res  2002  93:313-9  PubMed ID: 11927014   DOI: 10.1111/j.1349-7006.2002.tb02174.x
13797  Enomoto M, Mori T, Park M.  Influence of serum supplements in culture medium on gonadotropin-releasing hormone effects on colony formation  Life Sci  2002  71(18):2153-60  PubMed ID: 12204773   DOI: 10.1016/s0024-3205(02)02015-5
3101  Matsushima-Nishiu M, Unoki M, Ono K, Tsunoda T, Minaguchi T, Kuramoto H, Nishida M, Satoh T, Tanaka T, Nakamura Y  Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.  Cancer Res  2001  61:3741-9  PubMed ID: 11325847  
13816  Enomoto M, Mori T, Park MK.  GnRH agonist Buserelin affects colony-forming efficiency of HHUA and Jurkat cells  Biochem Biophys Res Commun  2001  289(5):1180-7  PubMed ID: 11741317   DOI: 10.1006/bbrc.2001.6131
13792  Tanaka T, Umesaki N.  Cytokine regulation of apoptotic susceptibility in a human endometrial epithelial cell line  J Reprod Immunol  2000  47(2):105-19  PubMed ID: 10924745   DOI: 10.1016/s0165-0378(00)00062-0
13819  Tauchi H, Komatsu K, Ishizaki K, Yatagai F, Kato T.  Mutation spectrum of MSH3-deficient HHUA/chr.2 cells reflects in vivo activity of the MSH3 gene product in mismatch repair  Mutat Res  2000  447(2):155-64  PubMed ID: 10751599   DOI: 10.1016/s0027-5107(99)00199-2
13824  Tanaka T, Mizuno K, Miyama M, Chang L, Chen H, Ohtaki S, Umesaki N, Ogita S.  Enhanced Fas/CD95-mediated apoptosis by epidermal growth factor in human endometrial epithelial cells  Eur J Obstet Gynecol Reprod Biol  1999  86(2):189-94  PubMed ID: 10509790   DOI: 10.1016/s0301-2115(99)00048-2
14015  Kunishige I, Samejima Y, Shiki Y, Moriyama A, Meruelo D, Saji F, Murata Y.  Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase  Gynecol Oncol  1999  72(1):16-25  PubMed ID: 9889024   DOI: 10.1006/gyno.1998.5224
18137  Tanaka T, Mizuno K, Umesaki N, Ogita S.  Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor  Clin Exp Obstet Gynecol  1998  25(4):125-8  PubMed ID: 9987568  
13791  Chang L, Tanaka T, Umesaki N, Ogita S.  Differential apoptotic susceptibility to anti-Fas IgM and anticancer drugs in a human endometrial adenocarcinoma cell line HHUA on laminin and type I collagen  Osaka City Med J  1998  44(2):173-80  PubMed ID: 10097597  
13817  Tanaka T, Umesaki N, Mizuno K, Chang L, Ohtaki S, Ogita S.  Enhancement of apoptotic susceptibility by interleukin-1 beta in human endometrial epithelial cells  Gynecol Endocrinol  1998  12(5):315-9  PubMed ID: 9859023   DOI: 10.3109/09513599809012832
17977  Kagami I, Mizunuma H, Miyamoto S, Ibuki Y, Uchida T.  Quantification of estrogen receptor messenger RNA by quantitative polymerase chain reaction using internal standard fragment  Biochem Biophys Res Commun  1996  228(2):358-64  PubMed ID: 8920919   DOI: 10.1006/bbrc.1996.1666


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