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細胞番号 : 細胞名
RCB0565 : ATDC5  update : 2024/09/06
細胞特性(Comment:英)Differentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
細胞特性(日)マウスteratocarcinoma細胞 AT805 由来の亜株。軟骨細胞や色素細胞への分化能を有する。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Atsumi, Tadao
樹立者 Atsumi, Tadao
寄託日 1991
元の細胞 AT805
動物種 _mouse < Mammals
動物系統名 129
性別 Male
embryo
採取組織 embryo
病名 Teratocarcinoma AT805 derived
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_3894
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM/HamF12 + 5% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture or Medium Renewal : once/2-3 days
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
文献情報 Reference(英) 5件
Reference(日) 1件
利用者成果(英) 497件
利用者成果(日) 2件

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Reference(英)
1682  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.  Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.  J Cell Sci  2007  120(Pt 5):849-57  PubMed ID: 17298979   DOI: 10.1242/jcs.03388
1681  Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y.  Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro.  J Bone Miner Res  1997  12(8):1174-88  PubMed ID: 9258747   DOI: 10.1359/jbmr.1997.12.8.1174
1687  Shukunami C, Shigeno C, Atsumi T, Ishizeki K, Suzuki F, Hiraki Y.  Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.  J Cell Biol  1996  133(2):457-68  PubMed ID: 8609176   DOI: 10.1083/jcb.133.2.457
1688  Atsumi T, Miwa Y, Kimata K, Ikawa Y  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Cell Differ Dev  1990  30:109-16  PubMed ID: 2201423   DOI: 10.1016/0922-3371(90)90079-c
2605  Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S  Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.  Dev Growth Differ  1981  87:340-350  PubMed ID: 6793433   DOI: 10.1016/0012-1606(81)90157-3

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Reference(日)
2606  渥美忠男  マウス軟骨前駆細胞:ATDC5  生体の科学  1992  43:466   

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利用者成果(英)
19868  Shi L, Ura K, Takagi Y.  Effects of self-assembled type II collagen fibrils on the morphology and growth of pre-chondrogenic ATDC5 cells  Osteoarthr Cartil Open  2024  6(2):100450  PubMed ID: 38444516   DOI: 10.1016/j.ocarto.2024.100450
21646  Hong X, Liu X, Li B, Shi S, Xiao K, Xu T, Nie Y, Dai M, Zhu M.  Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways.  J Orthop Surg Res  2024  19(1):188  PubMed ID: 38500177   DOI: 10.1186/s13018-024-04640-z
21665  Li Q, Yang Z, Zhu M, Zhang W, Chen L, Chen H, Kang P.  Hypobaric hypoxia aggravates osteoarthritis via the alteration of the oxygen environment and bone remodeling in the subchondral zone.  FASEB J  2024  38(7):e23594  PubMed ID: 38573451   DOI: 10.1096/fj.202302368R
21721  Tsuboi E, Asakawa Y, Hirose N, Yanoshita M, Sumi C, Takano M, Onishi A, Nishiyama S, Kubo N, Kita D, Tanimoto K.  The role of semaphorin 3A on chondrogenic differentiation.  In Vitro Cell Dev Biol Anim  2024    PubMed ID: 38727898   DOI: 10.1007/s11626-024-00909-z
21774  Kawamura S, Furuya K, Sasaki N, Takeoka Y, Aizawa M, Kanzawa N.  Evaluation of alginate-coated β-tricalcium phosphate fiber scaffold for cell culture.  J Biomed Mater Res B Appl Biomater  2024  112(6):e35433  PubMed ID: 38817048   DOI: 10.1002/jbm.b.35433
21798  Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R.  Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.  JCI Insight  2024  9(11)  PubMed ID: 38855864   DOI: 10.1172/jci.insight.175486
21839  Tomida K, Kim J, Maeda E, Adachi T, Matsumoto T.  Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation.  Cell Tissue Res  2024    PubMed ID: 39042176   DOI: 10.1007/s00441-024-03905-7
21994  Nakano N, Tashiro E, Shimada T, Ebisawa M, Kojima S, Ayabe K, Yamamoto Y, Maeda S, Itoh F, Itoh S.  Involvement of mitogen- and stress-activated protein kinase (MSK)1 in BMP-6-induced chondrocyte differentiation.  J Biol Chem  2024  107806  PubMed ID: 39307301   DOI: 10.1016/j.jbc.2024.107806
22008  Kawaue H, Matsubara T, Nagano K, Ikedo A, Rojasawasthien T, Yoshimura A, Nakatomi C, Imai Y, Kakuta Y, Addison WN, Kokabu S.  KIF22 regulates mitosis and proliferation of chondrocyte cells.  iScience  2024  27(7):110151  PubMed ID: 38989461   DOI: 10.1016/j.isci.2024.110151
22134  Farrag M, Cordero-Barreal A, Ait Eldjoudi D, Varela-García M, Torrijos Pulpón C, Lago F, Essawy A, Soffar A, Pino J, Farrag Y, Gualillo O.  Impact of Chondrocyte Inflammation on Glial Cell Activation: The Mediating Role of Nitric Oxide.  Cartilage  2024    PubMed ID: 39469810   DOI: 10.1177/19476035241292323
22159  Alizadeh Sardroud H, Rosa GDS, Dust W, Cham TC, Roy G, Bater S, Chicoine A, Honaramooz A, Chen X, Eames BF.  Comparison study on hyaline cartilage versus fibrocartilage formation in a pig model by using 3D-bioprinted hydrogel and hybrid constructs  Biofabrication  2024  17(1)  PubMed ID: 39423833   DOI: 10.1088/1758-5090/ad88a6
22163  Sato S, Hanai T, Kanamoto T, Kawano F, Hikida M, Yokoi H, Take Y, Magome T, Ebina K, Mae T, Tanaka H, Nakata K.  Vibration acceleration enhances proliferation, migration, and maturation of C2C12 cells and promotes regeneration of muscle injury in male rats.  Physiol Rep  2024  12(4):e15905  PubMed ID: 38396237   DOI: 10.14814/phy2.15905
17758  Franco-Trepat E, Alonso-Pérez A, Guillán-Fresco M, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Belén Bravo S, López-López V, Jorge-Mora A, Cerón-Carrasco JP, Lois Iglesias A, Gómez R.  β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine  Antioxidants (Basel)  2023  12(2):371  PubMed ID: 36829930   DOI: 10.3390/antiox12020371
19565  Shunsuke Hirashima, Shinichiro Kaetsu, Yukino Kiyooka, Kimie Nakagawa  Vitamin K Converting Enzyme UBIAD1 Promotes the Proliferation and Differentiation of Mouse Chondrogenic ATDC5 Cells  BPB Reports  2023  6:176-182    DOI: 10.1248/bpbreports.6.6_176
19587  Wang H, Wu Z, Xu K.  CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5  Exp Ther Med  2023  25(6):303  PubMed ID: 37229323   DOI: 10.3892/etm.2023.12002
19870  Farrag Y, Ait Eldjoudi D, Farrag M, González-Rodríguez M, Ruiz-Fernández C, Cordero A, Varela-García M, Torrijos Pulpón C, Bouza R, Lago F, Pino J, Alvarez-Lorenzo C, Gualillo O.  Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage  Polymers (Basel)  2023  15(24):4635  PubMed ID: 38139888   DOI: 10.3390/polym15244635
19886  Guillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R.  Formononetin, a Beer Polyphenol with Catabolic Effects on Chondrocytes  Nutrients  2023  15(13):2959  PubMed ID: 37447284   DOI: 10.3390/nu15132959
19894  Kimira Y, Sato T, Sakamoto M, Osawa Y, Mano H.  Collagen-Derived Dipeptide Pro-Hyp Enhanced ATDC5 Chondrocyte Differentiation under Hypoxic Conditions  Molecules  2023  28(12):4664  PubMed ID: 37375217   DOI: 10.3390/molecules28124664
19931  van Kampen KA, Olaret E, Stancu IC, Duarte Campos DF, Fischer H, Mota C, Moroni L.  Hypotrochoidal scaffolds for cartilage regeneration  Mater Today Bio  2023  23:100830  PubMed ID: 37876709   DOI: 10.1016/j.mtbio.2023.100830
19932  Alizadeh Sardroud H, Chen X, Eames BF.  Applied Compressive Strain Governs Hyaline-like Cartilage versus Fibrocartilage-like ECM Produced within Hydrogel Constructs  Int J Mol Sci  2023  24(8):7410  PubMed ID: 37108575   DOI: 10.3390/ijms24087410
19934  Hafeez S, Decarli MC, Aldana A, Ebrahimi M, Ruiter FAA, Duimel H, van Blitterswijk C, Pitet LM, Moroni L, Baker MB.  In Situ Covalent Reinforcement of a Benzene-1,3,5-Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks  Adv Mater  2023  35(35):e2301242  PubMed ID: 37370137   DOI: 10.1002/adma.202301242
19951  Xu J, Zhi X, Zhang Y, Ding R.  Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis  Open Life Sci  2023  18(1):20220666  PubMed ID: 37589005   DOI: 10.1515/biol-2022-0666
21012  Yang X, Lin Y, Chen T, Hu W, Li P, Qiu X, Yang B, Liang A, Gao W.  YTHDF1 enhances chondrogenic differentiation by activating the Wnt/β-catenin signaling pathway.  Stem Cells Dev  2023    PubMed ID: 36647682   DOI: 10.1089/scd.2022.0216
21029  Kadoya K, Hara ES, Okada M, Jiao YY, Nakano T, Sasaki A, Matsumoto T.  Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments.  Regen Biomater  2023  10:rbac088  PubMed ID: 36683756   DOI: 10.1093/rb/rbac088
21049  Lyu J, Kubo T, Iwahashi S, Fukasawa K, Horie T, Nagamatsu K, Ikeno K, Nakamura G, Kamakura M, Hinoi E.  Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly.  Biol Pharm Bull  2023  46(2):348-353  PubMed ID: 36724964   DOI: 10.1248/bpb.b22-00654
21094  Hafeez S, Aldana A, Duimel H, Ruiter FAA, Decarli MC, Lapointe V, van Blitterswijk C, Moroni L, Baker MB.  Molecular tuning of a benzene-1,3,5-tricarboxamide supramolecular fibrous hydrogel enables control over viscoelasticity and creates tunable ECM-mimetic hydrogels and bioinks.  Adv Mater  2023  e2207053  PubMed ID: 36858040   DOI: 10.1002/adma.202207053
21217  Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L.  Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth.  Sci Rep  2023  13(1):8054  PubMed ID: 37198212   DOI: 10.1038/s41598-023-34965-4
21287  Alizadeh Sardroud H, Chen X, Eames BF.  Reinforcement of Hydrogels with a 3D-Printed Polycaprolactone (PCL) Structure Enhances Cell Numbers and Cartilage ECM Production under Compression.  J Funct Biomater  2023  14(6)  PubMed ID: 37367278   DOI: 10.3390/jfb14060313
21301  Okita K, Hikiji H, Koga A, Nagai-Yoshioka Y, Yamasaki R, Mitsugi S, Fujii W, Ariyoshi W.  Ascorbic acid enhances chondrocyte differentiation of ATDC5 by accelerating insulin receptor signaling.  Cell Biol Int  2023    PubMed ID: 37381608   DOI: 10.1002/cbin.12067
21303  Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M.  ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.  Int J Biol Macromol  2023  125670  PubMed ID: 37406898   DOI: 10.1016/j.ijbiomac.2023.125670
21427  Ma JC, Luo T, Feng B, Huang Z, Zhang Y, Huang H, Yang X, Wen J, Bai X, Cui ZK.  Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy.  J Nanobiotechnology  2023  21(1):361  PubMed ID: 37794470   DOI: 10.1186/s12951-023-02118-4
21502  Zou K, Ying J, Xu H, Zeng Q, Huang H, Chen W, Li X, Wang P, Jin H, Li J, Wu Y.  Aucubin Alleviates Intervertebral Disc Degeneration by Repressing NF-κB-NLRP3 Inflammasome Activation in Endplate Chondrocytes.  J Inflamm Res  2023  16:5899-5913  PubMed ID: 38084106   DOI: 10.2147/JIR.S439981
17624  Tateiwa D, Kaito T, Hashimoto K, Okada R, Kodama J, Kushioka J, Bal Z, Tsukazaki H, Nakagawa S, Ukon Y, Hirai H, Tian H, Alferiev I, Chorny M, Otsuru S, Okada S, Iwamoto M.  Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation  Front Cell Dev Biol  2022  10:802699  PubMed ID: 35359440   DOI: 10.3389/fcell.2022.802699
17653  Hafeez S, Passanha FR, Feliciano AJ, Ruiter FAA, Malheiro A, Lafleur RPM, Matsumoto NM, van Blitterswijk C, Moroni L, Wieringa P, LaPointe VLS, Baker MB.  Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D  Biomater Sci  2022  10:4740-4755  PubMed ID: 35861034   DOI: 10.1039/d2bm00312k
17673  Liu C, Chen Y.  Ketorolac tromethamine alleviates IL-1β-induced chondrocyte injury by inhibiting COX-2 expression  Exp Ther Med  2022  ;23(5):337.  PubMed ID: 35411209   DOI: 10.3892/etm.2022.11267
17705  Zhang Z, Yang P, Wang C, Tian R.  LncRNA CRNDE hinders the progression of osteoarthritis by epigenetic regulation of DACT1  Cell Mol Life Sci  2022  79(8):405  PubMed ID: 35802196   DOI: 10.1007/s00018-022-04427-7
17759  Lesage R, Ferrao Blanco MN, Narcisi R, Welting T, van Osch GJVM, Geris L.  An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis  BMC Biol  2022  20(1):253  PubMed ID: 36352408   DOI: 10.1186/s12915-022-01451-8
20540  Zhang Q, Bai X, Wang R, Zhao H, Wang L, Liu J, Li M, Chen Z, Wang Z, Li L, Wang D.  4-octyl Itaconate inhibits lipopolysaccharide (LPS)-induced osteoarthritis via activating Nrf2 signalling pathway.  J Cell Mol Med  2022    PubMed ID: 35068055   DOI: 10.1111/jcmm.17185
20552  Sadeghianmaryan A, Naghieh S, Yazdanpanah Z, Sardroud HA, Sharma NK, Wilson LD, Chen X.  Fabrication of chitosan/alginate/hydroxyapatite hybrid scaffolds using 3D printing and impregnating techniques for potential cartilage regeneration.  Int J Biol Macromol  2022    PubMed ID: 35124017   DOI: 10.1016/j.ijbiomac.2022.01.201
20568  Feng X, Lu J, Wu Y, Xu H.  MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1.  J Physiol Sci  2022  72(1):3  PubMed ID: 35148687   DOI: 10.1186/s12576-022-00827-3
16217  Rong Li, Zijing Guan, Shuyan Bi, Fanhua Wang, Liang He, Xin Niu, Yu You, Yuwei Liu, Yi Ding, Stefan Siwko, Ning Wang, Ziming Zhang, Yunyun Jin, Jian Luo  The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling  Cell Death Dis  2022  13(2):152  PubMed ID: 35165253   DOI: 10.1038/s41419-021-04455-4
16346  Hasenbein I, Sachse A, Hortschansky P, Schmuck KD, Horbert V, Anders C, Lehmann T, Huber R, Maslaris A, Layher F, Braun C, Roth A, Plöger F, Kinne RW.  Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model  Biomedicines  2022  10(2):513  PubMed ID: 35203721   DOI: 10.3390/biomedicines10020513
20591  Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP, Ma X, Wang X, Gartland A, Wang N, Shah KM, Zhang H, Cao X, Yang L, Liu M, Luo J.  A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.  Cell Discov  2022  8(1):24  PubMed ID: 35256606   DOI: 10.1038/s41421-022-00382-6
20611  Steinbusch MMF, van den Akker GGH, Cremers A, Witlox AMA, Staal HM, Peffers MJ, van Rhijn LW, Caron MMJ, Welting TJM.  Adaptation of the protein translational apparatus during ATDC5 chondrogenic differentiation.  Noncoding RNA Res  2022  7(2):55-65  PubMed ID: 35261930   DOI: 10.1016/j.ncrna.2022.02.003
20677  Ruiz-Fernández C, González-Rodríguez M, Abella V, Francisco V, Cordero-Barreal A, Ait Eldjoudi D, Farrag Y, Pino J, Conde-Aranda J, González-Gay MÁ, Mera A, Mobasheri A, García-Caballero L, Gándara-Cortés M, Lago F, Scotece M, Gualillo O.  WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.  Lab Invest  2022    PubMed ID: 35484291   DOI: 10.1038/s41374-022-00793-9
16755  Shimohata N, Harada Y, Hayano T.  Proteomic analysis of nascent polypeptide chains that potentially induce translational pausing during elongation  Biosci Biotechnol Biochem  2022  zbac097  PubMed ID: 35749475   DOI: 10.1093/bbb/zbac097
20762  Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ.  Mast4 determines the cell fate of MSCs for bone and cartilage development.  Nat Commun  2022  13(1):3960  PubMed ID: 35803931   DOI: 10.1038/s41467-022-31697-3
20789  Liao Y, Ren Y, Luo X, Mirando AJ, Long JT, Leinroth A, Ji RR, Hilton MJ.  Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.  Sci Signal  2022  15(744):eabn7082  PubMed ID: 35881692   DOI: 10.1126/scisignal.abn7082
20810  Tanaka M, Miyamoto Y, Sasa K, Yoshimura K, Yamada A, Shirota T, Kamijo R.  Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß.  In Vitro Cell Dev Biol Anim  2022    PubMed ID: 35925448   DOI: 10.1007/s11626-022-00680-z
20813  Kim J, Tomida K, Matsumoto T, Adachi T.  Spheroid culture for chondrocytes triggers early stage of endochondral ossification.  Biotechnol Bioeng  2022    PubMed ID: 35923099   DOI: 10.1002/bit.28203
20847  Franco-Trepat E, Guillán-Fresco M, Alonso-Pérez A, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Gualillo O, Jorge-Mora A, Bravo SB, Gómez R.  Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells.  Biomed Pharmacother  2022  155:113671  PubMed ID: 36108390   DOI: 10.1016/j.biopha.2022.113671
20861  Niu J, Wan X, Yu GY, Jiang S, Yi RN, Wu YP, Ouyang SH, Liang L, Kurihara H, Sun WY, Zhu XF, Zhang RH, Cao YF, He JB, Duan WJ, Li YF, He RR.  Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.  Redox Biol  2022  56:102437  PubMed ID: 36037588   DOI: 10.1016/j.redox.2022.102437
20871  Kikuchi K, Haneda M, Hayashi S, Maeda T, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Fujita M, Ikuta K, Anjiki K, Tachibana S, Onoi Y, Matsumoto T, Kuroda R.  P21 deficiency exhibits delayed endochondral ossification during fracture healing.  Bone  2022  116572  PubMed ID: 36180020   DOI: 10.1016/j.bone.2022.116572
21048  Kitaura Y, Nakamura U, Awada C, Yamaguchi M, Kim M, Ikeda Y, Matsuo Y, Moriishi T, Sawase T, Chung UI, Hojo H, Ohba S.  Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models.  Regen Ther  2022  21:584-595  PubMed ID: 36475024   DOI: 10.1016/j.reth.2022.11.002
17757  Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T.  Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2  Commun Biol  2021  4(1):326  PubMed ID: 33707608   DOI: 10.1038/s42003-021-01848-1
13061  Semba S, Kitamura N, Tsuda M, Goto K, Kurono S, Ohmiya Y, Kurokawa T, Gong JP, Yasuda K, Tanaka S.  Synthetic poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function.  J Biomed Mater Res A  2021    PubMed ID: 32496623   DOI: 10.1002/jbm.a.37028
13408  Wang B, Sun W, Bi K, Li Y, Li F.  Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1.  Int J Mol Med  2021    PubMed ID: 33448323   DOI: 10.3892/ijmm.2021.4845
13441  Kai Li Panpan Yang Yuwei Zhang Yue Zhang He Cao Peilin Liu Bin Huang Song Xu Pinglin Lai Guanghua Lei Jia Liu Yujin Tang Xiaochun Bai Zhipeng Zou  DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes  J Bone Miner Res  2021  36(2):400-411  PubMed ID: 32916025   DOI: 10.1002/jbmr.4176
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7433  Umeda M, Terao F, Miyazaki K, Yoshizaki K, Takahashi I.  MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage.  J. Dent. Res.  2015  94:795-802  PubMed ID: 25784252   DOI: 10.1177/0022034515577411
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7487  Abella V, Santoro A, Scotece M, Conde J, Lopez-Lopez V, Lazzaro V, Gomez-Reino JJ, Meli R, Gualillo O.  Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.  Toxicol. Lett.  2015  234:13-9  PubMed ID: 25659934   DOI: 10.1016/j.toxlet.2015.02.001
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3917  Hutchison MR, White PC.  Prostacyclin regulates bone growth via the Epac/Rap1 pathway.  Endocrinology  2015  156(2):499-510  PubMed ID: 25406016   DOI: 10.1210/en.2014-1348
6005  Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.  Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.  Bone Res  2015  3:15021  PubMed ID: 26558140   DOI: 10.1038/boneres.2015.21
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6613  Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.  GDF-5 can act as a context-dependent BMP-2 antagonist.  BMC Biol  2015  13:77  PubMed ID: 26385096   DOI: 10.1186/s12915-015-0183-8
6614  Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W.  MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.  FEBS Lett  2015  589(23):3671-8  PubMed ID: 26474644   DOI: 10.1016/j.febslet.2015.09.032
6615  Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.  A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.  Sci Signal  2015  8(386):ra71  PubMed ID: 26198357   DOI: 10.1126/scisignal.aaa3792
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6617  Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston TN.  Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension.  Elife  2015  4:e09300  PubMed ID: 26652004   DOI: 10.7554/eLife.09300
6620  Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T.  AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.  Bone  2015  74:125-33  PubMed ID: 25497570   DOI: 10.1016/j.bone.2014.12.001
6469  Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.  6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.  Mol Nutr Food Res  2014  58(2):256-66  PubMed ID: 24039109   DOI: 10.1002/mnfr.201200833
3517  Kosaka T, Fukui R, Matsui M, Kurosaka Y, Nishimura H, Tanabe M, Takakura Y, Iwai K, Waki T, Fujita T.  RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.  PLoS One  2014  9(9):e108819  PubMed ID: 25275461   DOI: 10.1371/journal.pone.0108819
6579  Kawamura D, Funakoshi T, Mizumoto S, Sugahara K, Iwasaki N.  Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.  J Orthop Sci  2014  19(6):1028-35  PubMed ID: 25209441   DOI: 10.1007/s00776-014-0643-y
6580  Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K.  Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells.  BMC Musculoskelet Disord  2014  15:222  PubMed ID: 24997593   DOI: 10.1186/1471-2474-15-222
6581  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.  High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.  J Orthop Res  2014  32(12):1619-27  PubMed ID: 25196420   DOI: 10.1002/jor.22691
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6585  Eijiro Maeda et al  Significant increase in Young׳s modulus of ATDC5 cells during chondrogenic differentiation induced by PAMPS/PDMAAm double-network gel: Comparison with induction by insulin  Journal of Biomechanics  2014  47:3408-3414  PubMed ID: 25110167   DOI: 10.1016/j.jbiomech.2014.07.021
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6587  Scotece M, Conde J, Abella V, López V, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study.  J Orthop Res  2014  32(5):653-60  PubMed ID: 24464950   DOI: 10.1002/jor.22585
6588  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.  Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.  In Vitro Cell Dev Biol Anim  2014  50(4):358-66  PubMed ID: 24092017   DOI: 10.1007/s11626-013-9692-3
6589  Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.  LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.  Biochem Biophys Res Commun  2014  451(2):302-7  PubMed ID: 25091481   DOI: 10.1016/j.bbrc.2014.07.125
6590  Gómez R, Conde J, Scotece M, López V, Lago F, Gómez Reino JJ, Gualillo O.  Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes.  J Orthop Res  2014  32(9):1137-46  PubMed ID: 24902823   DOI: 10.1002/jor.22660
6591  Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.  S100A1 and S100B are dispensable for endochondral ossification during skeletal development.  Biomed Res  2014  35(4):243-50  PubMed ID: 25152033   DOI: 10.2220/biomedres.35.243
6592  Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.  Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.  PLoS One  2014  9(3):e91421  PubMed ID: 24618907   DOI: 10.1371/journal.pone.0091421
6593  Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K  Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.  J Biol Chem  2014  289(20):13810-20  PubMed ID: 24711445   DOI: 10.1074/jbc.M113.543322
6594  Staines KA, Zhu D, Farquharson C, MacRae VE.  Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.  J Bone Miner Metab  2014  32(3):240-51  PubMed ID: 23925391   DOI: 10.1007/s00774-013-0493-2
6595  Bergmann CJ1, Odekerken JC2, Welting TJ2, Jungwirth F, Devine D3, Bouré L3, Zeiter S3, van Rhijn LW2, Telle R4, Fischer H1, Emans PJ2.  Calcium phosphate based three-dimensional cold plotted bone scaffolds for critical size bone defects.  Biomed Res Int  2014  2014:852610  PubMed ID: 24719891   DOI: 10.1155/2014/852610
6596  Ushijima T, Okazaki K, Tsushima H, Ishihara K, Doi T, Iwamoto Y.  CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.  PLoS One  2014  9(8):e104547  PubMed ID: 25105964   DOI: 10.1371/journal.pone.0104547
6597  Woo E, Park H, Lee KY.  Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.  Macromol Biosci  2014  14(5):740-8  PubMed ID: 24436180   DOI: 10.1002/mabi.201300365
6598  Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT.  Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.  PLoS One  2014  9(3):e92194  PubMed ID: 24637783   DOI: 10.1371/journal.pone.0092194
6599  Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.  Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.  PLoS One  2014  9(3):e92699  PubMed ID: 24658359   DOI: 10.1371/journal.pone.0092699
6600  Hatta T, Kishimoto KN, Okuno H, Itoi E.  Oxygen tension affects lubricin expression in chondrocytes.  Tissue Eng Part A  2014  20(19-20):2720-7  PubMed ID: 24712343   DOI: 10.1089/ten.TEA.2013.0353
6601  Jasmin L. Whittaker a, Namita R. Choudhury, Naba K. Dutta and Andrew Zannettino    J Mater Chem B  2014  2:6259-6270  PubMed ID: 32262143   DOI: 10.1039/C4TB00698D
6602  Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura S.  Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.  Biochim Biophys Acta  2014  1840(1):645-55  PubMed ID: 24161698   DOI: 10.1016/j.bbagen.2013.10.027
6603  Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme NJ, Haines P, Chen Q.  Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells.  Int J Mol Sci  2014  15(8):14555-73  PubMed ID: 25196597   DOI: 10.3390/ijms150814555
6604  Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.  J Biol Chem  2014  89(14):9865-79  PubMed ID: 24563464   DOI: 10.1074/jbc.M113.520585
6605  Inagaki Y, Kitamura N, Kurokawa T, Tanaka Y, Gong JP, Yasuda K, Tohyama H.  Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study.  BMC Musculoskelet Disord  2014  15:320  PubMed ID: 25262146   DOI: 10.1186/1471-2474-15-320
6606  Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.  J Biol Chem  2014  289(12):8135-50  PubMed ID: 24505141   DOI: 10.1074/jbc.M113.509331
6607  Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.  Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.  Neurochem Int  2014  74:24-35  PubMed ID: 24768841   DOI: 10.1016/j.neuint.2014.04.010
6430  Kwon HJ, Ohmiya Y.  Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.  Biomed Res Int  2013  2013:213972  PubMed ID: 23878799   DOI: 10.1155/2013/213972
6464  Gómez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O.  Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes.  J Orthop Res  2013  31(7):1046-52  PubMed ID: 23483583   DOI: 10.1002/jor.22331
6465  Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.  Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.  J Biol Chem  2013  288(40):28620-9  PubMed ID: 23963448   DOI: 10.1074/jbc.M113.452169
6556  Nepal M, Li L, Cho HK, Park JK, Soh Y.  Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway.  Food Chem Toxicol  2013  62:238-45  PubMed ID: 23989061   DOI: 10.1016/j.fct.2013.08.034
6557  Miyatake K, Tsuji K, Yamaga M, Yamada J, Matsukura Y, Abula K, Sekiya I, Muneta T.  Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells.  Biochem Biophys Res Commun  2013  431(1):52-7  PubMed ID: 23291184   DOI: 10.1016/j.bbrc.2012.12.094
6558  Hu-Hui Lee, Jing-Yu Lee & Lan-Hsin   Proper Fhl1 expression as Wnt signaling is required for chondrogenesis of ATDC5 cells  Animal Cells and Systems  2013  17:413-420    DOI: 10.1080/19768354.2013.856341
6559  Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R.  Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.  Cell Tissue Res  2013  352(2):401-12  PubMed ID: 23274552   DOI: 10.1007/s00441-012-1548-8
6560  Mitani K1 Haruyama N, Hatakeyama J, Igarashi K.  Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells.  Oral Dis  2013  19(2):169-79  PubMed ID: 22863294   DOI: 10.1111/j.1601-0825.2012.01967.x
6561  Morimoto H, Baba R, Haneji T, Doi Y.  Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5.  Cell Tissue Res  2013  351(1):41-7  PubMed ID: 23180319   DOI: 10.1007/s00441-012-1521-6
6562  Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.  Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.  J Pharmacol Sci  2013  122(4):318-25  PubMed ID: 23883486   DOI: 10.1254/jphs.13091fp
6563  Yoshikawa K, Kitamura N, Kurokawa T, Gong JP, Nohara Y, Yasuda K.  Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.  BMC Musculoskelet Disord  2013  14:56  PubMed ID: 23379610   DOI: 10.1186/1471-2474-14-56
6564  Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.  Proc Natl Acad Sci U S A  2013  110(5):1875-80  PubMed ID: 23319657   DOI: 10.1073/pnas.1207458110
6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878   DOI: 10.1002/art.37779
6566  Kwon HJ.  ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.  Cell Biochem Funct  2013  31(1):75-81  PubMed ID: 22886426   DOI: 10.1002/cbf.2862
6567  Lambrechts D, Roeffaers M, Kerckhofs G, Roberts SJ, Hofkens J, Van de Putte T, Van Oosterwyck H, Schrooten J.  Fluorescent oxygen sensitive microbead incorporation for measuring oxygen tension in cell aggregates.  Biomaterials  2013  34(4):922-9  PubMed ID: 23122803   DOI: 10.1016/j.biomaterials.2012.10.019
6568  Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM.  CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress.  J Cell Commun Signal  2013  7(3):219-30  PubMed ID: 23666466   DOI: 10.1007/s12079-013-0201-y
6569  Zheng Z, Ren L, Zhai Z, Wang Y, Hang F.  Surface modification on polyethylene terephthalate films with 2-methacryloyloxyethyl phosphorylcholine.  Mater Sci Eng C Mater Biol Appl  2013  33(5):3041-6  PubMed ID: 23623130   DOI: 10.1016/j.msec.2013.03.036
6570  Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M.  Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.  FEBS Open Bio  2013  3:279-84  PubMed ID: 23905010   DOI: 10.1016/j.fob.2013.07.001
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7711  Mirza R, Qiao S, Tateyama K, Miyamoto T, Xiuli L, Seo H.  3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.  J. Bone Miner. Metab.  2012  30:144-53  PubMed ID: 21845517   DOI: 10.1007/s00774-011-0303-7
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6520  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C.  Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.  Am J Physiol Endocrinol Metab  2009  296(6):E1374-82  PubMed ID: 19401455   DOI: 10.1152/ajpendo.91018.2008
6531  Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.  Arthritis Rheum  2009  60(11):3314-23  PubMed ID: 19877062   DOI: 10.1002/art.24878
6532  Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung U, Nakamura K, Kawaguchi H.  Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.  Osteoarthritis Cartilage  2009  17(8):1065-75  PubMed ID: 19254740   DOI: 10.1016/j.joca.2009.02.003
6533  Arthritis Rheum  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917   DOI: 10.1002/art.24243
6534  Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A.  Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.  J Cell Biochem  2009  106(4):580-8  PubMed ID: 19142862   DOI: 10.1002/jcb.22029
6535  Heinecke K, Seher A, Schmitz W, Mueller TD, Sebald W, Nickel J.  Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.  BMC Biol  2009  7:59  PubMed ID: 19735544   DOI: 10.1186/1741-7007-7-59
6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746   DOI: 10.1186/1471-213X-9-70
6537  Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K. Author information  Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.  Nat Cell Biol  2009  11(10):1197-204  PubMed ID: 19767744   DOI: 10.1038/ncb1962
6538  Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T.  Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.  Mol Biol Cell  2009  20(21):4541-51  PubMed ID: 19759178   DOI: 10.1091/mbc.e09-03-0227
6539  Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C.  Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.  J Cell Physiol  2009  218(2):276-84  PubMed ID: 18803233   DOI: 10.1002/jcp.21593
8784  Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  FEBS J.  2008  275:172-83  PubMed ID: 18070108   DOI: 10.1111/j.1742-4658.2007.06187.x
6510  Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y.  Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.  Genes Cells  2008  13(4):355-63  PubMed ID: 18363966   DOI: 10.1111/j.1365-2443.2008.01170.x
6511  Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.  A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.  J Mol Biol  2008  381(4):1025-39  PubMed ID: 18621057   DOI: 10.1016/j.jmb.2008.06.074
6512  Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O.  Development of a cell culture system loading cyclic mechanical strain to chondrogenic cells.  J Biotechnol  2008  133(2):231-8  PubMed ID: 17904677   DOI: 10.1016/j.jbiotec.2007.08.007
6513  Galal N, El Beialy W, Deyama Y, Yoshimura Y, Yoshikawa T, Suzuki K, Totsuka Y.  Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements.  Int J Mol Med  2008  21(6):785-90  PubMed ID: 18506373  
6514  Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.  Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.  J Biol Chem  2008  283(39):26499-508  PubMed ID: 18632667   DOI: 10.1074/jbc.M800933200
6515  Tanne Y, Tanimoto K, Tanaka N, Ueki M, Lin YY, Ohkuma S, Kamiya T, Tanaka E, Tanne K.  Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation.  Arch Oral Biol  2008  53(5):478-87  PubMed ID: 18242579   DOI: 10.1016/j.archoralbio.2007.12.007
6516  Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T.  Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.  Osteoarthritis Cartilage  2008  16(6):723-32  PubMed ID: 18226559   DOI: 10.1016/j.joca.2007.10.014
6517  Takarada T, Hinoi E, Takahata Y, Yoneda Y.  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.  J Cell Physiol  2008  215(2):320-8  PubMed ID: 17929246   DOI: 10.1002/jcp.21310
6518  Roberts SJ, Owen HC, Farquharson C.  Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.  Biochem Biophys Res Commun  2008  371(4):872-6  PubMed ID: 18471996   DOI: 10.1016/j.bbrc.2008.04.163
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373
6521  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.  Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.  J Biol Chem  2008  283(36):24682-9  PubMed ID: 18617520   DOI: 10.1074/jbc.M709857200
6522  Schugar RC, Robbins PD, Deasy BM.  Small molecules in stem cell self-renewal and differentiation.  Gene Ther  2008  15(2):126-35  PubMed ID: 17989703   DOI: 10.1038/sj.gt.3303062
6523  Tiğli RS, Gümüşderelioğlu M.  Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity.  Int J Biol Macromol  2008  43(2):121-8  PubMed ID: 18485469   DOI: 10.1016/j.ijbiomac.2008.04.003
6524  Owen HC, Roberts SJ, Ahmed SF, Farquharson C.  Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.  Am J Physiol Endocrinol Metab  2008  294(6):E1023-34  PubMed ID: 18381927   DOI: 10.1152/ajpendo.00586.2007
12384  Boileau C, Poirier F, Pelletier JP, Guévremont M, Duval N, Martel-Pelletier J, Reboul P.  Intracellular localisation of galectin-3 has a protective role in chondrocyte survival  Ann Rheum Dis  2008  67(2):175-81  PubMed ID: 17545192   DOI: 10.1136/ard.2006.066514
18910  Dadsetan M, Szatkowski JP, Yaszemski MJ, Lu L.  Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering  Biomacromolecules  2007  8(5):1702-9  PubMed ID: 17419584   DOI: 10.1021/bm070052h
3584  Muramatsu S, Wakabayashi M, Ohno T, Amano K, Ooishi R, Sugahara T, Shiojiri S, Tashiro K, Suzuki Y, Nishimura R, Kuhara S, Sugano S, Yoneda T, Matsuda A.  Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.  J Biol Chem  2007  282(44):32158-67  PubMed ID: 17804410   DOI: 10.1074/jbc.M706158200
6167  Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH.  Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.  Dev Dyn  2007  236(5):1313-8  PubMed ID: 17436279   DOI: 10.1002/dvdy.21137
6494  Nakatani S, Mano H, Im R, Shimizu J, Wada M.  Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5.  Biol Pharm Bull  2007  30(3):433-8  PubMed ID: 17329833   DOI: 10.1248/bpb.30.433
6495  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.  The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.  Biomaterials  2007  28(3):434-40  PubMed ID: 16978693   DOI: 10.1016/j.biomaterials.2006.08.050
6496  Narukawa M, Suzuki N, Takayama T, Shoji T, Otsuka K, Ito K.  Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells.  J Periodontal Res  2007  42(2):131-7  PubMed ID: 17305871   DOI: 10.1111/j.1600-0765.2006.00926.x
6497  Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.  Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.  Biochim Biophys Acta  2007  1774(9):1108-17  PubMed ID: 17669701   DOI: 10.1016/j.bbapap.2007.06.005
6498  Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S.  Mechanisms for asporin function and regulation in articular cartilage.  J Biol Chem  2007  282(44):32185-92  PubMed ID: 17827158   DOI: 10.1074/jbc.M700522200
6499  Macrae VE, Ahmed SF, Mushtaq T, Farquharson C.  IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.  Growth Horm IGF Res  2007  17(5):435-9  PubMed ID: 17590365   DOI: 10.1016/j.ghir.2007.05.002
6500  Hinoi E, Takarada T, Fujimori S, Wang L, Iemata M, Uno K, Yoneda Y.  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.  Bone  2007  40(2):337-44  PubMed ID: 17029980   DOI: 10.1016/j.bone.2006.08.016
6501  Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.  Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.  Dev Biol  2007  312(2):572-81  PubMed ID: 17997399   DOI: 10.1016/j.ydbio.2007.10.001
6502  Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.  Novel function of TWEAK in inducing intervertebral disc degeneration.  J Orthop Res  2007  25(11):1438-46  PubMed ID: 17568422   DOI: 10.1002/jor.20445
6503  Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA.  Regulation of the human SOX9 promoter by Sp1 and CREB.  Exp Cell Res  2007  313(6):1069-79  PubMed ID: 17289023   DOI: 10.1016/j.yexcr.2007.01.001
6504  Owen HC, Miner JN, Ahmed SF, Farquharson C.  The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.  Mol Cell Endocrinol  2007  264(1-2):164-70  PubMed ID: 17182172   DOI: 10.1016/j.mce.2006.11.006
6505  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Identification and characterization of the human SOX6 promoter.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257   DOI: 10.1016/j.bbrc.2007.03.133
6506  Huang BL, Dornbach LM, Lyons KM.  The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.  J Cell Commun Signal  2007  1(1):17-32  PubMed ID: 18481207   DOI: 10.1007/s12079-007-0003-1
6507  Takeuchi S, Mukai N, Tateishi T, Miyakawa S.  Production of sex steroid hormones from DHEA in articular chondrocyte of rats.  Am J Physiol Endocrinol Metab  2007  293(1):E410-5  PubMed ID: 17473054   DOI: 10.1152/ajpendo.00042.2007
6509  Ishii I, Mizuta H, Sei A, Hirose J, Kudo S, Hiraki Y.  Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.  J Bone Joint Surg Br  2007  89(5):693-700  PubMed ID: 17540759   DOI: 10.1302/0301-620X.89B5.18450
4863  Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.  Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5.  J Bone Miner Metab  2006  24(2):153-7  PubMed ID: 16502123   DOI: 10.1007/s00774-005-0662-z
6478  Nakatani S, Mano H, Ryanghyok IM, Shimizu J, Wada M.  Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.  Biochem Biophys Res Commun  2006  348(3):1157-62  PubMed ID: 16904632   DOI: 10.1016/j.bbrc.2006.07.180
6479  Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.  The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.  Calcif Tissue Int  2006  78(3):171-7  PubMed ID: 16523220   DOI: 10.1007/s00223-005-1233-y
6481  Reinhold MI, Kapadia RM, Liao Z, Naski MC.  The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis.  J Biol Chem  2006  281(3):1381-8  PubMed ID: 16293629   DOI: 10.1074/jbc.M504875200
6482  Kanda Y1, Hisayasu S, Fukai F, Takase B.  Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms.  Life Sci  2006  78(6):640-8  PubMed ID: 16111716   DOI: 10.1016/j.lfs.2005.05.081
6483  Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, Ikegawa S.  Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene.  Biochem Biophys Res Commun  2006  341(1):121-7  PubMed ID: 16413503   DOI: 10.1016/j.bbrc.2005.12.159
6484  Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.  Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.  Eur J Pharmacol  2006  542(1-3):48-53  PubMed ID: 16828741   DOI: 10.1016/j.ejphar.2006.06.006
6485  Stewart AJ, Houston B, Farquharson C.  Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.  J Cell Physiol  2006  206(2):435-40  PubMed ID: 16155924   DOI: 10.1002/jcp.20481
6486  Phornphutkul C, Wu KY, Gruppuso PA.  The role of insulin in chondrogenesis.  Mol Cell Endocrinol  2006  249(1-2):107-15  PubMed ID: 16530934   DOI: 10.1016/j.mce.2006.02.002
6487  Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y.  Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.  J Biol Chem  2006  281(33):23632-42  PubMed ID: 16777848   DOI: 10.1074/jbc.M512362200
6488  Chen L, Fink T, Ebbesen P, Zachar V.  Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions.  Tissue Eng  2006  12(3):559-67  PubMed ID: 16579689   DOI: 10.1089/ten.2006.12.559
6489  Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A.  TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.  Arthritis Res Ther  2006  8(5):R146  PubMed ID: 16945157   DOI: 10.1186/ar2038
6490  Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.  Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.  J Biol Chem  2006  281(37):27229-41  PubMed ID: 16835229   DOI: 10.1074/jbc.M603385200
6491  MacRae VE, Farquharson C, Ahmed SF.  The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.  J Endocrinol  2006  189(2):319-28  PubMed ID: 16648299   DOI: 10.1677/joe.1.06609
6492  MacRae VE, Burdon T, Ahmed SF, Farquharson C.  Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.  J Endocrinol  2006  191(2):369-77  PubMed ID: 17088406   DOI: 10.1677/joe.1.06958
6976  Nagai N, Anzawa T, Satoh Y, Suzuki T, Tajima K, Munekata M.  Activities of MC3T3-E1 cells cultured on gamma-irradiated salmon atelocollagen scaffold.  J Biosci Bioeng  2006  101(6):511-4  PubMed ID: 16935254   DOI: 10.1263/jbb.101.511
2874  Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Biochem Biophys Res Commun  2005  333:1300-8  PubMed ID: 15979579   DOI: 10.1016/j.bbrc.2005.06.041
3120  Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446   DOI: 10.1007/s11010-005-8159-6
3194  Hinoi E, Wang L, Takemori A, Yoneda Y.  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296   DOI: 10.1016/j.bcp.2005.04.025
5399  Takumi Tamayama, Kentaro Maemura, Kiyoto Kanbara,Hana Hayasaki, Yasuaki Yabumoto, Masayoshi Yuasa,and Masahito Watanabe  Expression of GABAAand GABABreceptorsin rat growth plate chondrocytes: Activationof the GABA receptors promotes proliferationof mouse chondrogenic ATDC5 cells  Molecular and Cellular Biochemistry  2005  273:117–126   
4989  Kirimoto A1, Takagi Y, Ohya K, Shimokawa H.  Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5.  J Med Dent Sci  2005  52(3):153-62  PubMed ID: 16350840  
5412  Chen L, Fink T, Zhang XY, Ebbesen P, Zachar V.  Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis.  Differentiation  2005  73(7):350-63  PubMed ID: 16219039   DOI: 10.1111/j.1432-0436.2005.00038.x
5972  Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R.  Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.  Biochem J  2005  389(Pt 2):315-23  PubMed ID: 15784009   DOI: 10.1042/BJ20041996
6221  Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.  Hum Mol Genet  2005  14(8):1009-17  PubMed ID: 15746150   DOI: 10.1093/hmg/ddi093
6230  Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.  Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.  J Cell Physiol  2005  204(3):927-33  PubMed ID: 15795936   DOI: 10.1002/jcp.20350
6245  Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K.  Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.  Exp Cell Res  2005  310(2):256-69  PubMed ID: 16165127   DOI: 10.1016/j.yexcr.2005.07.025
4968  Okada A, Shiomi T, Aoki Y, Fujiwara M.  Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.  J Toxicol Sci  2005  30(3):145-56  PubMed ID: 16141649   DOI: 10.2131/jts.30.145
6222  Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P.  GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton.  Bone  2005  37(2):139-47  PubMed ID: 15946906   DOI: 10.1016/j.bone.2005.04.015
6871  Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG.  Regulation of the human Sox9 promoter by the CCAAT-binding factor.  Matrix Biol   2005  24(3):185-97  PubMed ID: 15908194   DOI: 10.1016/j.matbio.2005.04.001
3158  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495   DOI: 10.1016/j.yexcr.2003.12.018
2899  Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  J Cell Biol  2004  166:85-95  PubMed ID: 15226309   DOI: 10.1083/jcb.200401138
2926  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410   DOI: 10.1016/S0002-9440(10)63348-2
2900  Nakajima M, Negishi Y, Tanaka H, Kawashima K.  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198   DOI: 10.1016/j.bbrc.2004.06.057
3330  Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Molecular recognition of BMP-2 and BMP receptor IA.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755   DOI: 10.1038/nsmb756
6247  Fujita T, Fukuyama R, Enomoto H, Komori T.  Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.  J Cell Biochem  2004  93(2):374-83  PubMed ID: 15368363   DOI: 10.1002/jcb.20192
6294  Yamagiwa H, Yamada Y, Bolander ME, Sarkar G.  Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell.  Mol Biotechnol  2004  28(1):1-8  PubMed ID: 15456958   DOI: 10.1385/MB:28:1:01
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