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Cell No. : Cell Name
RCB0565 : ATDC5  update : 2024/09/06
CommentDifferentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Atsumi, Tadao
Originator Atsumi, Tadao
Year of deposit 1991
Original cell AT805
Animal _mouse < Mammals
Strain name 129
Gender Male
Age at sampling embryo
Tissue embryo
Disease name Teratocarcinoma AT805 derived
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3894
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM/HamF12 + 5% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Reference information Reference 5
User's Publication 494


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Reference
1682  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.  Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.  J Cell Sci  2007  120(Pt 5):849-57  PubMed ID: 17298979   DOI: 10.1242/jcs.03388
1681  Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y.  Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro.  J Bone Miner Res  1997  12(8):1174-88  PubMed ID: 9258747   DOI: 10.1359/jbmr.1997.12.8.1174
1687  Shukunami C, Shigeno C, Atsumi T, Ishizeki K, Suzuki F, Hiraki Y.  Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.  J Cell Biol  1996  133(2):457-68  PubMed ID: 8609176   DOI: 10.1083/jcb.133.2.457
1688  Atsumi T, Miwa Y, Kimata K, Ikawa Y  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Cell Differ Dev  1990  30:109-16  PubMed ID: 2201423   DOI: 10.1016/0922-3371(90)90079-c
2605  Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S  Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.  Dev Growth Differ  1981  87:340-350  PubMed ID: 6793433   DOI: 10.1016/0012-1606(81)90157-3

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User's Publication
19868  Shi L, Ura K, Takagi Y.  Effects of self-assembled type II collagen fibrils on the morphology and growth of pre-chondrogenic ATDC5 cells  Osteoarthr Cartil Open  2024  6(2):100450  PubMed ID: 38444516   DOI: 10.1016/j.ocarto.2024.100450
21646  Hong X, Liu X, Li B, Shi S, Xiao K, Xu T, Nie Y, Dai M, Zhu M.  Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways.  J Orthop Surg Res  2024  19(1):188  PubMed ID: 38500177   DOI: 10.1186/s13018-024-04640-z
21665  Li Q, Yang Z, Zhu M, Zhang W, Chen L, Chen H, Kang P.  Hypobaric hypoxia aggravates osteoarthritis via the alteration of the oxygen environment and bone remodeling in the subchondral zone.  FASEB J  2024  38(7):e23594  PubMed ID: 38573451   DOI: 10.1096/fj.202302368R
21721  Tsuboi E, Asakawa Y, Hirose N, Yanoshita M, Sumi C, Takano M, Onishi A, Nishiyama S, Kubo N, Kita D, Tanimoto K.  The role of semaphorin 3A on chondrogenic differentiation.  In Vitro Cell Dev Biol Anim  2024    PubMed ID: 38727898   DOI: 10.1007/s11626-024-00909-z
21774  Kawamura S, Furuya K, Sasaki N, Takeoka Y, Aizawa M, Kanzawa N.  Evaluation of alginate-coated β-tricalcium phosphate fiber scaffold for cell culture.  J Biomed Mater Res B Appl Biomater  2024  112(6):e35433  PubMed ID: 38817048   DOI: 10.1002/jbm.b.35433
21798  Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R.  Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.  JCI Insight  2024  9(11)  PubMed ID: 38855864   DOI: 10.1172/jci.insight.175486
21839  Tomida K, Kim J, Maeda E, Adachi T, Matsumoto T.  Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation.  Cell Tissue Res  2024    PubMed ID: 39042176   DOI: 10.1007/s00441-024-03905-7
21994  Nakano N, Tashiro E, Shimada T, Ebisawa M, Kojima S, Ayabe K, Yamamoto Y, Maeda S, Itoh F, Itoh S.  Involvement of mitogen- and stress-activated protein kinase (MSK)1 in BMP-6-induced chondrocyte differentiation.  J Biol Chem  2024  107806  PubMed ID: 39307301   DOI: 10.1016/j.jbc.2024.107806
22008  Kawaue H, Matsubara T, Nagano K, Ikedo A, Rojasawasthien T, Yoshimura A, Nakatomi C, Imai Y, Kakuta Y, Addison WN, Kokabu S.  KIF22 regulates mitosis and proliferation of chondrocyte cells.  iScience  2024  27(7):110151  PubMed ID: 38989461   DOI: 10.1016/j.isci.2024.110151
17758  Franco-Trepat E, Alonso-Pérez A, Guillán-Fresco M, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Belén Bravo S, López-López V, Jorge-Mora A, Cerón-Carrasco JP, Lois Iglesias A, Gómez R.  β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine  Antioxidants (Basel)  2023  12(2):371  PubMed ID: 36829930   DOI: 10.3390/antiox12020371
19565  Shunsuke Hirashima, Shinichiro Kaetsu, Yukino Kiyooka, Kimie Nakagawa  Vitamin K Converting Enzyme UBIAD1 Promotes the Proliferation and Differentiation of Mouse Chondrogenic ATDC5 Cells  BPB Reports  2023  6:176-182    DOI: 10.1248/bpbreports.6.6_176
19587  Wang H, Wu Z, Xu K.  CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5  Exp Ther Med  2023  25(6):303  PubMed ID: 37229323   DOI: 10.3892/etm.2023.12002
19870  Farrag Y, Ait Eldjoudi D, Farrag M, González-Rodríguez M, Ruiz-Fernández C, Cordero A, Varela-García M, Torrijos Pulpón C, Bouza R, Lago F, Pino J, Alvarez-Lorenzo C, Gualillo O.  Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage  Polymers (Basel)  2023  15(24):4635  PubMed ID: 38139888   DOI: 10.3390/polym15244635
19886  Guillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R.  Formononetin, a Beer Polyphenol with Catabolic Effects on Chondrocytes  Nutrients  2023  15(13):2959  PubMed ID: 37447284   DOI: 10.3390/nu15132959
19894  Kimira Y, Sato T, Sakamoto M, Osawa Y, Mano H.  Collagen-Derived Dipeptide Pro-Hyp Enhanced ATDC5 Chondrocyte Differentiation under Hypoxic Conditions  Molecules  2023  28(12):4664  PubMed ID: 37375217   DOI: 10.3390/molecules28124664
19931  van Kampen KA, Olaret E, Stancu IC, Duarte Campos DF, Fischer H, Mota C, Moroni L.  Hypotrochoidal scaffolds for cartilage regeneration  Mater Today Bio  2023  23:100830  PubMed ID: 37876709   DOI: 10.1016/j.mtbio.2023.100830
19932  Alizadeh Sardroud H, Chen X, Eames BF.  Applied Compressive Strain Governs Hyaline-like Cartilage versus Fibrocartilage-like ECM Produced within Hydrogel Constructs  Int J Mol Sci  2023  24(8):7410  PubMed ID: 37108575   DOI: 10.3390/ijms24087410
19934  Hafeez S, Decarli MC, Aldana A, Ebrahimi M, Ruiter FAA, Duimel H, van Blitterswijk C, Pitet LM, Moroni L, Baker MB.  In Situ Covalent Reinforcement of a Benzene-1,3,5-Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks  Adv Mater  2023  35(35):e2301242  PubMed ID: 37370137   DOI: 10.1002/adma.202301242
19951  Xu J, Zhi X, Zhang Y, Ding R.  Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis  Open Life Sci  2023  18(1):20220666  PubMed ID: 37589005   DOI: 10.1515/biol-2022-0666
21012  Yang X, Lin Y, Chen T, Hu W, Li P, Qiu X, Yang B, Liang A, Gao W.  YTHDF1 enhances chondrogenic differentiation by activating the Wnt/β-catenin signaling pathway.  Stem Cells Dev  2023    PubMed ID: 36647682   DOI: 10.1089/scd.2022.0216
21029  Kadoya K, Hara ES, Okada M, Jiao YY, Nakano T, Sasaki A, Matsumoto T.  Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments.  Regen Biomater  2023  10:rbac088  PubMed ID: 36683756   DOI: 10.1093/rb/rbac088
21049  Lyu J, Kubo T, Iwahashi S, Fukasawa K, Horie T, Nagamatsu K, Ikeno K, Nakamura G, Kamakura M, Hinoi E.  Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly.  Biol Pharm Bull  2023  46(2):348-353  PubMed ID: 36724964   DOI: 10.1248/bpb.b22-00654
21094  Hafeez S, Aldana A, Duimel H, Ruiter FAA, Decarli MC, Lapointe V, van Blitterswijk C, Moroni L, Baker MB.  Molecular tuning of a benzene-1,3,5-tricarboxamide supramolecular fibrous hydrogel enables control over viscoelasticity and creates tunable ECM-mimetic hydrogels and bioinks.  Adv Mater  2023  e2207053  PubMed ID: 36858040   DOI: 10.1002/adma.202207053
21217  Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L.  Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth.  Sci Rep  2023  13(1):8054  PubMed ID: 37198212   DOI: 10.1038/s41598-023-34965-4
21287  Alizadeh Sardroud H, Chen X, Eames BF.  Reinforcement of Hydrogels with a 3D-Printed Polycaprolactone (PCL) Structure Enhances Cell Numbers and Cartilage ECM Production under Compression.  J Funct Biomater  2023  14(6)  PubMed ID: 37367278   DOI: 10.3390/jfb14060313
21301  Okita K, Hikiji H, Koga A, Nagai-Yoshioka Y, Yamasaki R, Mitsugi S, Fujii W, Ariyoshi W.  Ascorbic acid enhances chondrocyte differentiation of ATDC5 by accelerating insulin receptor signaling.  Cell Biol Int  2023    PubMed ID: 37381608   DOI: 10.1002/cbin.12067
21303  Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M.  ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.  Int J Biol Macromol  2023  125670  PubMed ID: 37406898   DOI: 10.1016/j.ijbiomac.2023.125670
21427  Ma JC, Luo T, Feng B, Huang Z, Zhang Y, Huang H, Yang X, Wen J, Bai X, Cui ZK.  Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy.  J Nanobiotechnology  2023  21(1):361  PubMed ID: 37794470   DOI: 10.1186/s12951-023-02118-4
21502  Zou K, Ying J, Xu H, Zeng Q, Huang H, Chen W, Li X, Wang P, Jin H, Li J, Wu Y.  Aucubin Alleviates Intervertebral Disc Degeneration by Repressing NF-κB-NLRP3 Inflammasome Activation in Endplate Chondrocytes.  J Inflamm Res  2023  16:5899-5913  PubMed ID: 38084106   DOI: 10.2147/JIR.S439981
17624  Tateiwa D, Kaito T, Hashimoto K, Okada R, Kodama J, Kushioka J, Bal Z, Tsukazaki H, Nakagawa S, Ukon Y, Hirai H, Tian H, Alferiev I, Chorny M, Otsuru S, Okada S, Iwamoto M.  Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation  Front Cell Dev Biol  2022  10:802699  PubMed ID: 35359440   DOI: 10.3389/fcell.2022.802699
17653  Hafeez S, Passanha FR, Feliciano AJ, Ruiter FAA, Malheiro A, Lafleur RPM, Matsumoto NM, van Blitterswijk C, Moroni L, Wieringa P, LaPointe VLS, Baker MB.  Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D  Biomater Sci  2022  10:4740-4755  PubMed ID: 35861034   DOI: 10.1039/d2bm00312k
17673  Liu C, Chen Y.  Ketorolac tromethamine alleviates IL-1β-induced chondrocyte injury by inhibiting COX-2 expression  Exp Ther Med  2022  ;23(5):337.  PubMed ID: 35411209   DOI: 10.3892/etm.2022.11267
17705  Zhang Z, Yang P, Wang C, Tian R.  LncRNA CRNDE hinders the progression of osteoarthritis by epigenetic regulation of DACT1  Cell Mol Life Sci  2022  79(8):405  PubMed ID: 35802196   DOI: 10.1007/s00018-022-04427-7
17759  Lesage R, Ferrao Blanco MN, Narcisi R, Welting T, van Osch GJVM, Geris L.  An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis  BMC Biol  2022  20(1):253  PubMed ID: 36352408   DOI: 10.1186/s12915-022-01451-8
20540  Zhang Q, Bai X, Wang R, Zhao H, Wang L, Liu J, Li M, Chen Z, Wang Z, Li L, Wang D.  4-octyl Itaconate inhibits lipopolysaccharide (LPS)-induced osteoarthritis via activating Nrf2 signalling pathway.  J Cell Mol Med  2022    PubMed ID: 35068055   DOI: 10.1111/jcmm.17185
20552  Sadeghianmaryan A, Naghieh S, Yazdanpanah Z, Sardroud HA, Sharma NK, Wilson LD, Chen X.  Fabrication of chitosan/alginate/hydroxyapatite hybrid scaffolds using 3D printing and impregnating techniques for potential cartilage regeneration.  Int J Biol Macromol  2022    PubMed ID: 35124017   DOI: 10.1016/j.ijbiomac.2022.01.201
20568  Feng X, Lu J, Wu Y, Xu H.  MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1.  J Physiol Sci  2022  72(1):3  PubMed ID: 35148687   DOI: 10.1186/s12576-022-00827-3
16217  Rong Li, Zijing Guan, Shuyan Bi, Fanhua Wang, Liang He, Xin Niu, Yu You, Yuwei Liu, Yi Ding, Stefan Siwko, Ning Wang, Ziming Zhang, Yunyun Jin, Jian Luo  The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling  Cell Death Dis  2022  13(2):152  PubMed ID: 35165253   DOI: 10.1038/s41419-021-04455-4
16346  Hasenbein I, Sachse A, Hortschansky P, Schmuck KD, Horbert V, Anders C, Lehmann T, Huber R, Maslaris A, Layher F, Braun C, Roth A, Plöger F, Kinne RW.  Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model  Biomedicines  2022  10(2):513  PubMed ID: 35203721   DOI: 10.3390/biomedicines10020513
20591  Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP, Ma X, Wang X, Gartland A, Wang N, Shah KM, Zhang H, Cao X, Yang L, Liu M, Luo J.  A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.  Cell Discov  2022  8(1):24  PubMed ID: 35256606   DOI: 10.1038/s41421-022-00382-6
20611  Steinbusch MMF, van den Akker GGH, Cremers A, Witlox AMA, Staal HM, Peffers MJ, van Rhijn LW, Caron MMJ, Welting TJM.  Adaptation of the protein translational apparatus during ATDC5 chondrogenic differentiation.  Noncoding RNA Res  2022  7(2):55-65  PubMed ID: 35261930   DOI: 10.1016/j.ncrna.2022.02.003
20677  Ruiz-Fernández C, González-Rodríguez M, Abella V, Francisco V, Cordero-Barreal A, Ait Eldjoudi D, Farrag Y, Pino J, Conde-Aranda J, González-Gay MÁ, Mera A, Mobasheri A, García-Caballero L, Gándara-Cortés M, Lago F, Scotece M, Gualillo O.  WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.  Lab Invest  2022    PubMed ID: 35484291   DOI: 10.1038/s41374-022-00793-9
16755  Shimohata N, Harada Y, Hayano T.  Proteomic analysis of nascent polypeptide chains that potentially induce translational pausing during elongation  Biosci Biotechnol Biochem  2022  zbac097  PubMed ID: 35749475   DOI: 10.1093/bbb/zbac097
20762  Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ.  Mast4 determines the cell fate of MSCs for bone and cartilage development.  Nat Commun  2022  13(1):3960  PubMed ID: 35803931   DOI: 10.1038/s41467-022-31697-3
20789  Liao Y, Ren Y, Luo X, Mirando AJ, Long JT, Leinroth A, Ji RR, Hilton MJ.  Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.  Sci Signal  2022  15(744):eabn7082  PubMed ID: 35881692   DOI: 10.1126/scisignal.abn7082
20810  Tanaka M, Miyamoto Y, Sasa K, Yoshimura K, Yamada A, Shirota T, Kamijo R.  Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß.  In Vitro Cell Dev Biol Anim  2022    PubMed ID: 35925448   DOI: 10.1007/s11626-022-00680-z
20813  Kim J, Tomida K, Matsumoto T, Adachi T.  Spheroid culture for chondrocytes triggers early stage of endochondral ossification.  Biotechnol Bioeng  2022    PubMed ID: 35923099   DOI: 10.1002/bit.28203
20847  Franco-Trepat E, Guillán-Fresco M, Alonso-Pérez A, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Gualillo O, Jorge-Mora A, Bravo SB, Gómez R.  Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells.  Biomed Pharmacother  2022  155:113671  PubMed ID: 36108390   DOI: 10.1016/j.biopha.2022.113671
20861  Niu J, Wan X, Yu GY, Jiang S, Yi RN, Wu YP, Ouyang SH, Liang L, Kurihara H, Sun WY, Zhu XF, Zhang RH, Cao YF, He JB, Duan WJ, Li YF, He RR.  Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.  Redox Biol  2022  56:102437  PubMed ID: 36037588   DOI: 10.1016/j.redox.2022.102437
20871  Kikuchi K, Haneda M, Hayashi S, Maeda T, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Fujita M, Ikuta K, Anjiki K, Tachibana S, Onoi Y, Matsumoto T, Kuroda R.  P21 deficiency exhibits delayed endochondral ossification during fracture healing.  Bone  2022  116572  PubMed ID: 36180020   DOI: 10.1016/j.bone.2022.116572
21048  Kitaura Y, Nakamura U, Awada C, Yamaguchi M, Kim M, Ikeda Y, Matsuo Y, Moriishi T, Sawase T, Chung UI, Hojo H, Ohba S.  Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models.  Regen Ther  2022  21:584-595  PubMed ID: 36475024   DOI: 10.1016/j.reth.2022.11.002
17757  Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T.  Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2  Commun Biol  2021  4(1):326  PubMed ID: 33707608   DOI: 10.1038/s42003-021-01848-1
13061  Semba S, Kitamura N, Tsuda M, Goto K, Kurono S, Ohmiya Y, Kurokawa T, Gong JP, Yasuda K, Tanaka S.  Synthetic poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function.  J Biomed Mater Res A  2021    PubMed ID: 32496623   DOI: 10.1002/jbm.a.37028
13408  Wang B, Sun W, Bi K, Li Y, Li F.  Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1.  Int J Mol Med  2021    PubMed ID: 33448323   DOI: 10.3892/ijmm.2021.4845
13441  Kai Li Panpan Yang Yuwei Zhang Yue Zhang He Cao Peilin Liu Bin Huang Song Xu Pinglin Lai Guanghua Lei Jia Liu Yujin Tang Xiaochun Bai Zhipeng Zou  DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes  J Bone Miner Res  2021  36(2):400-411  PubMed ID: 32916025   DOI: 10.1002/jbmr.4176
13533  Takano I, Takeshita N, Yoshida M, Seki D, Oyanagi T, Kimura S, Jiang W, Sasaki K, Sogi C, Kawatsu M, Takano-Yamamoto T.  Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization  J Cell Physiol  2021  236(4):2906-2919  PubMed ID: 32960451   DOI: 10.1002/jcp.30058
13544  Caron MMJ, van Rietbergen B, Castermans TMR, Haartmans MJJ, van Rhijn LW, Welting TJM, Witlox AMA.  Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents  J Orthop Res  2021  39(3):553-564  PubMed ID: 32740982   DOI: 10.1002/jor.24819
13588  Maenohara Y, Chijimatsu R, Tachibana N, Uehara K, Xuan F, Mori D, Murahashi Y, Nakamoto H, Oichi T, Chang SH, Matsumoto T, Omata Y, Yano F, Tanaka S, Saito T.  Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells  J Bone Miner Res  2021  36(4):792-802  PubMed ID: 33617044   DOI: 10.1002/jbmr.4226
20192  Kitagawa A, Yamaguchi M, Fujiwara A, Shimizu M, Takahashi A, Sone H, Kamiyama S.  Genistein inhibits chondrogenic differentiation and mineralization of ATDC5 cells.  Biochem Biophys Res Commun  2021  566:123-128  PubMed ID: 34119824   DOI: 10.1016/j.bbrc.2021.05.101
20237  Jokoji G, Maeda S, Oishi K, Ijuin T, Nakajima M, Tawaratsumida H, Kawamura I, Tominaga H, Taketomi E, Ikegawa S, Taniguchi N.  CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1.  J Biol Chem  2021  100994  PubMed ID: 34298017   DOI: 10.1016/j.jbc.2021.100994
14887  Takano M, Hirose N, Sumi C, Yanoshita M, Nishiyama S, Onishi A, Asakawa Y, Tanimoto K.  ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes  Cartilage  2021  1947603519878242  PubMed ID: 31581797   DOI: 10.1177/1947603519878242
20256  Garcia de Vinuesa A, Sanchez-Duffhues G, Blaney-Davidson E, van Caam A, Lodder K, Ramos Y, Kloppenburg M, Meulenbelt I, van der Kraan P, Goumans MJ, Ten Dijke P.  Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis.  J Pathol  2021    PubMed ID: 34357595   DOI: 10.1002/path.5774
15282  Jin Liu, Xiaohao Wu, Jun Lu, Guangxin Huang, Lei Dang, Huarui Zhang, Chuanxin Zhong, Zongkang Zhang, Dijie Li, Fangfei Li, Chao Liang, Yuanyuan Yu, Bao-Ting Zhang, Lin Chen, Aiping Lu, Ge Zhang  Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression  Nature Aging  2021  1:368-384    DOI: 10.1038/s43587-021-00050-6
15526  Caron MMJ, Eveque M, Cillero-Pastor B, Heeren RMA, Housmans B, Derks K, Cremers A, Peffers MJ, van Rhijn LW, van den Akker G, Welting TJM.  Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins  Front Cell Dev Biol  2021  9:686096  PubMed ID: 34235151   DOI: 10.3389/fcell.2021.686096
20444  Roh HH, Kim HS, Kim C, Lee KY.  3D Printing of Polysaccharide-Based Self-Healing Hydrogel Reinforced with Alginate for Secondary Cross-Linking.  Biomedicines  2021  9(9)  PubMed ID: 34572410   DOI: 10.3390/biomedicines9091224
16284  Zhu M, Xu Q, Yang X, Zhan H, Zhang B, Liu X, Dai M.  Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts  Front Pharmacol  2021  12:764598  PubMed ID: 35095488   DOI: 10.3389/fphar.2021.764598
16746  Sun M, Wang W, Min L, Chen C, Li Q, Weng W.  Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway  J Orthop Surg Res  2021  16(1):129  PubMed ID: 33573682   DOI: 10.1186/s13018-021-02260-5
16762  Wang W, Zhu Y, Sun Z, Jin C, Wang X.  Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling  Arthritis Res Ther  2021  23(1):84  PubMed ID: 33726807   DOI: 10.1186/s13075-021-02456-4
16977  Ruiz-Fernández C, Gonzalez-Rodríguez M, Francisco V, Rajab IM, Gómez R, Conde J, Lago F, Pino J, Mobasheri A, Gonzalez-Gay MA, Mera A, Potempa LA, Gualillo O.  Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes  Lab Invest  2021  101(12):1550-1560  PubMed ID: 33767361   DOI: 10.1038/s41374-021-00584-8
17084  Conde J, Ruiz-Fernandez C, Francisco V, Scotece M, Gómez R, Lago F, Gonzalez-Gay MA, Pino J, Mobasheri A, Gualillo O.  Dickkopf-3 (DKK3) Signaling in IL-1α-Challenged Chondrocytes: Involvement of the NF-κB Pathway  Cartilage  2021  13(2_suppl):925S-934S  PubMed ID: 32532182   DOI: 10.1177/1947603520933328
17417  Yoshikawa Y, Izawa T, Hamada Y, Takenaga H, Wang Z, Ishimaru N, Kamioka H.  Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis  Sci Rep  2021  11(1):14927  PubMed ID: 34290363   DOI: 10.1038/s41598-021-94470-4
17756  Shimo T, Takebe H, Okui T, Kunisada Y, Ibaragi S, Obata K, Kurio N, Shamsoon K, Fujii S, Hosoya A, Irie K, Sasaki A, Iwamoto M.  Expression and Role of IL-1β Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing  Int J Mol Sci  2020  21(7):2365  PubMed ID: 32235405   DOI: 10.3390/ijms21072365
11605  Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.  Loss of autophagy in chondrocytes causes severe growth retardation.  Autophagy  2020  16(3):501-511  PubMed ID: 31203752   DOI: 10.1080/15548627.2019.1628541
11853  Li C, Zheng Z, Ha P, Jiang W, Berthiaume EA, Lee S, Mills Z, Pan H, Chen EC, Jiang J, Culiat CT, Zhang X, Ting K, Soo C.  Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug.  Biomaterials  2020    PubMed ID: 31634652   DOI: 10.1016/j.biomaterials.2019.119541
6910  Dong Y, Yan X, Yang X, Yu C, Deng Y, Song X, Zhang L.  Notoginsenoside R1 suppresses miR-301a via NF-κB pathway in lipopolysaccharide-treated ATDC5 cells.  Exp Mol Pathol  2020  112:104355  PubMed ID: 31837326   DOI: 10.1016/j.yexmp.2019.104355
6950  Kim JM, Han H, Bahn M, Hur Y, Yeo CY, Kim DW.  Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened.  Biochem J  2020  477(1):121-136  PubMed ID: 31845979   DOI: 10.1042/BCJ20190784
11975  Hirose N, Okamoto Y, Yanoshita M, Asakawa Y, Sumi C, Takano M, Nishiyama S, Su SC, Mitsuyoshi T, Kunimatsu R, Tanne K, Tanimoto K.  Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress.  Cell Biol. Int.  2020    PubMed ID: 31876323   DOI: 10.1002/cbin.11293
11976  Ukita M, Matsushita K, Tamura M, Yamaguchi T.  Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis.  Int. J. Mol. Med.  2020    PubMed ID: 31894302   DOI: 10.3892/ijmm.2019.4446
11982  Chu J, Yan B, Zhang J, Peng L, Ao X, Zheng Z, Jiang T, Zhang Z.  Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.  Inflammation  2020    PubMed ID: 31897918   DOI: 10.1007/s10753-019-01167-y
12101  Okada K, Mori D, Makii Y, Nakamoto H, Murahashi Y, Yano F, Chang SH, Taniguchi Y, Kobayashi H, Semba H, Takeda N, Piao W, Hanaoka K, Nagano T, Tanaka S, Saito T.  Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.  Sci Rep  2020    PubMed ID: 32214220   DOI: 10.1038/s41598-020-62463-4
12114  Jiang Q, Qin X, Yoshida CA, Komori H, Yamana K, Ohba S, Hojo H, Croix BS, Kawata-Matsuura VKS, Komori T.  Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis.  Int J Mol Sci  2020    PubMed ID: 32244499   DOI: 10.3390/ijms21072425
12324  Komuro H, Wint WY, Horiuchi N, Nozaki K, Sasano T, Miyashin M, Yamashita K, Nagai A.  An oriented hydroxyapatite film with arrayed plate-like particles enhance chondrogenic differentiation of ATDC5 cells  J Biomed Mater Res A   2020  108(3):537-544  PubMed ID: 31702862   DOI: 10.1002/jbm.a.36834
12389  Cheng BF, Lian JJ, Yang HJ, Wang L, Yu HH, Bi JJ, Gao YX, Chen SJ, Wang M, Feng ZW.  Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis  Stem Cells Transl Med  2020  9(2):273-283  PubMed ID: 31742919   DOI: 10.1002/sctm.19-0190
13026  Korpayev S, Toprak Ö, Kaygusuz G, Şen M, Orhan K, Karakeçili A.  Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix.  Colloids Surf B Biointerfaces  2020    PubMed ID: 32531647   DOI: 10.1016/j.colsurfb.2020.111111
13078  Irmak G, Gumusderelioglu M.  Photoactivated platelet rich plasma (PRP) based patient-specific bio-ink for cartilage tissue engineering.  Biomed Mater  2020    PubMed ID: 32554884   DOI: 10.1088/1748-605X/ab9e46
13101  Chen Z, Lin CX, Song B, Li CC, Qiu JX, Li SX, Lin SP, Luo WQ, Fu Y, Fang GB, Wei-Ping L, Saw PE, Ding Y.  Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis.  Cell Death Dis  2020    PubMed ID: 32632306   DOI: 10.1038/s41419-020-2710-y
13147  Kobayashi M, Chijimatsu R, Yoshikawa H, Yoshida K.  Extracorporeal shock wave therapy accelerates endochondral ossification and fracture healing in a rat femur delayed-union model.  Biochem Biophys Res Commun  2020    PubMed ID: 32762942   DOI: 10.1016/j.bbrc.2020.07.084
13184  Sadeghianmaryan A, Naghieh S, Alizadeh Sardroud H, Yazdanpanah Z, Afzal Soltani Y, Sernaglia J, Chen X.  Extrusion-based printing of chitosan scaffolds and their in vitro characterization for cartilage tissue engineering.  Int J Biol Macromol  2020    PubMed ID: 32853616   DOI: 10.1016/j.ijbiomac.2020.08.180
13255  Ueda Y, Hirota K, Yamauchi I, Hakata T, Yamashita T, Fujii T, Yasoda A, Inagaki N.  Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect.  PLoS One  2020    PubMed ID: 33002060   DOI: 10.1371/journal.pone.0240023
13368  Li X, Chen S, Hu Z, Chen D, Wang J, Li Z, Li Z, Cui H, Dai G, Liu L, Wang H, Zhang K, Zheng Z, Zhan Z, Liu H.  Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis.  EMBO Mol Med  2020    PubMed ID: 33259138   DOI: 10.15252/emmm.202012109
13436  Koichiro Ono, Kenji Hata, Eriko Nakamura, Shota Ishihara, Sachi Kobayashi, Masako Nakanishi, Michiko Yoshida, Yoshifumi Takahata, Tomohiko Murakami, Seiichi Takenoshita, Toshihisa Komori, Riko Nishimura, Toshiyuki Yoneda  Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2    2020      DOI: 10.21203/rs.3.rs-62864/v1
13452      Arthritis Res.  2020      DOI: 10.21203/rs.3.rs-93713/v1
13526  Hu G, Zhang N, Li J, Wang J, Wu W, Li J, Tong W, Zhao X, Dai L, Zhang X.  Tumor Necrosis Factor Receptor Associated Factor 3 Modulates Cartilage Degradation through Suppression of Interleukin 17 Signaling  Am J Pathol  2020  190(8):1701-1712  PubMed ID: 32416098   DOI: 10.1016/j.ajpath.2020.04.016
13548  Wilhelm D, Kempf H, Bianchi A, Vincourt JB.  ATDC5 cells as a model of cartilage extracellular matrix neosynthesis, maturation and assembly  J Proteomics  2020  219:103718  PubMed ID: 32097723   DOI: 10.1016/j.jprot.2020.103718
13549  Ota M, Tanaka Y, Nakagawa I, Jiang JJ, Arima Y, Kamimura D, Onodera T, Iwasaki N, Murakami M.  Role of Chondrocytes in the Development of Rheumatoid Arthritis Via Transmembrane Protein 147-Mediated NF-κB Activation  Arthritis Rheumatol  2020  72(6):931-942  PubMed ID: 31785076   DOI: 10.1002/art.41182
13625  Ibaraki K, Hayashi S, Kanzaki N, Hashimoto S, Kihara S, Haneda M, Takeuchi K, Niikura T, Kuroda R.  Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation  Mol Med Rep  2020  21(5):2236-2242  PubMed ID: 32186772   DOI: 10.3892/mmr.2020.11028
13844  Hashimoto D, Semba S, Tsuda M, Kurokawa T, Kitamura N, Yasuda K, Gong JP, Tanaka S.  Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation  Biochem Biophys Res Commun  2020  528(1):120-126  PubMed ID: 32456794   DOI: 10.1016/j.bbrc.2020.05.071
13907  Lee DS, Roh SY, Choi H, Park JC.  NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development  Mol Cells  2020  43(8):739-748  PubMed ID: 32759468   DOI: 10.14348/molcells.2020.2272
13940  Masanori A. MURAYAMA, Yoichiro IWAKURA  C1q/TNF-related protein 3 regulates chondrogenic cell proliferation via adiponectin receptor 2 (progestin and adipoQ receptor 2)  Translational and Regulatory Sciences  2020  2:19-23   
14859  Masutani T, Yamada S, Hara A, Takahashi T, Green PG, Niwa M.  Exogenous Application of Proteoglycan to the Cell Surface Microenvironment Facilitates to Chondrogenic Differentiation and Maintenance  Int J Mol Sci   2020  21(20):7744  PubMed ID: 33086766   DOI: 10.3390/ijms21207744
14934  Jaiswal PK, Aljebali L, Gaumond MH, Oh CD, Yasuda H, Moffatt P.  Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9  Sci Rep  2020  10(1):7790.  PubMed ID: 32385306   DOI: 10.1038/s41598-020-64640-x
17755  Kim SW, Kim DY, Roh HH, Kim HS, Lee JW, Lee KY.  Three-Dimensional Bioprinting of Cell-Laden Constructs Using Polysaccharide-Based Self-Healing Hydrogels  Biomacromolecules  2019  20(5):1860-1866  PubMed ID: 30912929   DOI: 10.1021/acs.biomac.8b01589
11328  Liu G, Wang Y, Zhang M, Zhang Q.  Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30521964   DOI: 10.1016/j.intimp.2018.11.038
11356  Shimo T, Koyama E, Okui T, Masui M, Kunisada Y, Ibaragi S, Yoshioka N, Kurio N, Yoshida S, Sasaki A, Iwamoto M.  Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression.  In Vivo  2019    PubMed ID: 30587607   DOI: 10.21873/invivo.11443
11403  Yamaguchi Y, Kanzaki H, Miyamoto Y, Itohiya K, Fukaya S, Katsumata Y, Nakamura Y.  Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth.  Bone  2019    PubMed ID: 30682567   DOI: 10.1016/j.bone.2019.01.020
11417  Steinbusch MMF, Caron MMJ, Surtel DAM, van den Akker GGH, van Dijk PJ, Friedrich F, Zabel B, van Rhijn LW, Peffers MJ, Welting TJM.  The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.  J. Biol. Chem.  2019    PubMed ID: 30718282   DOI: 10.1074/jbc.RA119.007356
11438  Ying H, Wang Y, Gao Z, Zhang Q.  Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30771739   DOI: 10.1016/j.intimp.2019.01.056
11449  Lin C, Liu L, Zeng C, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D, Bai X.  Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12.  Bone Res  2019    PubMed ID: 30792936   DOI: 10.1038/s41413-018-0041-8
11478  Lian C, Wang X, Qiu X, Wu Z, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.  Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction.  Bone Res  2019    PubMed ID: 30854241   DOI: 10.1038/s41413-019-0046-y
4055  Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.  Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.  Nat Commun  2019  10:1442  PubMed ID: 30926814   DOI: 10.1038/s41467-019-09491-5
11510  Choi S, Kim HY, Cha PH, Seo SH, Lee C, Choi Y, Shin W, Heo Y, Han G, Lee W, Choi KY.  CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.  Life Sci Alliance  2019    PubMed ID: 30971423   DOI: 10.26508/lsa.201800254
11512  Chu P, Wang Q, Wang Z, Gao C.  Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30981080   DOI: 10.1016/j.intimp.2019.04.004
11519  Horita M, Nishida K, Hasei J, Furumatsu T, Sakurai M, Onodera Y, Fukuda K, Salter DM, Ozaki T.  Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions.  Calcif. Tissue Int.  2019    PubMed ID: 30993375   DOI: 10.1007/s00223-019-00549-6
11532  Yu C, Shi D, Li Z, Wan G, Shi X.  Long noncoding RNA CHRF exacerbates IL-6-induced inflammatory damages by downregulating microRNA-146a in ATDC5 cells.  J. Cell. Physiol.  2019    PubMed ID: 31026064   DOI: 10.1002/jcp.28749
11564  Zhang Q, Wang Y, Zhang M, Ying H.  Green tea polyphenols attenuate LPS-induced inflammation through upregulating microRNA-9 in murine chondrogenic ATDC5 cells.  J. Cell. Physiol.  2019    PubMed ID: 31102286   DOI: 10.1002/jcp.28826
11588  Liu Q, Li M, Jiang L, Jiang R, Fu B.  METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31186141   DOI: 10.1016/j.bbrc.2019.05.168
11592  Ueda Y, Yasoda A, Hirota K, Yamauchi I, Yamashita T, Kanai Y, Sakane Y, Fujii T, Inagaki N.  Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment.  Sci Rep  2019    PubMed ID: 31189976   DOI: 10.1038/s41598-019-44975-w
11597  Li X, Yu M, Han L, Chen L, Zhang D, Zhou G, Zhao Q, Sun T.  LINC00305 represses miR-124 expression to trigger inflammatory insults in the presence of lipopolysaccharide.  Artif Cells Nanomed Biotechnol  2019    PubMed ID: 31190561   DOI: 10.1080/21691401.2019.1624559
11606  Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X.  MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.  Mol. Cell. Biochem.  2019    PubMed ID: 31227976   DOI: 10.1007/s11010-019-03563-2
11650  Li Y, Mu W, Ren J, Wuermanbieke S, Wahafu T, Ji B, Ma H, Amat A, Zhang K, Cao L.  Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.  Int. J. Mol. Med.  2019    PubMed ID: 31364719   DOI: 10.3892/ijmm.2019.4290
11680  Al HalifaSoultan, Dennis Lambrechts, Thomas Verheyen, Hans Van Gorp, Maarten B.J. Roeffaers, Mario Smet, Wim M. De Borggraeve, Jennifer Patterson  Nanocarrier systems assembled from PEGylated hyperbranched poly(arylene oxindole)  European Polymer Journal  2019      DOI: 10.1016/j.eurpolymj.2019.07.029
11741  Ogawa Y, Takahashi N, Takemoto T, Nishiume T, Suzuki M, Ishiguro N, Kojima T.  Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells.  PLoS ONE  2019    PubMed ID: 31393869   DOI: 10.1371/journal.pone.0219492
11785  Gunnella F, Kunisch E, Horbert V, Maenz S, Bossert J, Jandt KD, Plöger F, Kinne RW.  In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.  Pharmaceutics  2019    PubMed ID: 31484306   DOI: 10.3390/pharmaceutics11090455
11789  Mei X, Tong J, Zhu W, Zhu Y.  lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes.  Mol Med Rep  2019    PubMed ID: 31485657   DOI: 10.3892/mmr.2019.10639
11803  Choi S, Cha PH, Kim HY, Choi KY.  Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway.  Exp. Mol. Med.  2019    PubMed ID: 31515471   DOI: 10.1038/s12276-019-0306-3
11843  Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y.  FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.  J. Biol. Chem.  2019    PubMed ID: 31601652   DOI: 10.1074/jbc.RA119.009409
6878  Yano F, Ohba S, Murahashi Y, Tanaka S, Saito T, Chung UI.  Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation.  Sci Rep  2019  9(1):7666  PubMed ID: 31113964   DOI: 10.1038/s41598-019-43948-3
9791  Carolina Gonçalves-Fernández, Jorge Sineiro, Ramón Moreira & Oreste Gualillo   Extraction and characterization of phlorotannin-enriched fractions from the Atlantic seaweed Bifurcaria bifurcata and evaluation of their cytotoxic activity in murine cell line  Journal of Applied Phycology volume  2019  31:2573–2583    DOI: 10.1007/s10811-018-1729-2
11915  Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, Mori Y, Makii Y, Oichi T, Taketo MM, Hojo H, Ohba S, Chung UI, Tanaka S, Saito T.  Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.  Arthritis Res. Ther.  2019    PubMed ID: 31771658   DOI: 10.1186/s13075-019-2041-5
12385  Liu M, Zhang J, Liu W, Wang W.  Salidroside protects ATDC5 cells against lipopolysaccharide-induced injury through up-regulation of microRNA-145 in osteoarthritis  Int Immunopharmacol  2019  67:441-448  PubMed ID: 30586667   DOI: 10.1016/j.intimp.2018.12.041
12386  Nakatani S, Taguchi Y, Ueda H, Ishida Y, Morita Y, Kato K, Wada M, Kobata K.  Short communication: Milk basic protein promotes proliferation and inhibits differentiation of mouse chondrogenic ATDC5 cells  J Dairy Sci  2019  102(4):2873-2878  PubMed ID: 30712929   DOI: 10.3168/jds.2018-15656
12387  Li J, Han G, Ma M, Wei G, Shi X, Guo Z, Li T, Meng H, Cao Y, Liu X.  Xanthan Gum Ameliorates Osteoarthritis and Mitigates Cartilage Degradation via Regulation of the Wnt3a/β-Catenin Signaling Pathway  Med Sci Monit  2019  25:7488-7498  PubMed ID: 31587011   DOI: 10.12659/MSM.916092
12388  Li Q, Xing W, Xu X, Wang S, He Y, Wang Y, Sun H.  Tetramethylpyrazine alleviates lipopolysaccharide-induced damage in ATDC5 cells via down-regulating MyD88  Exp Mol Pathol  2019  111:104317  PubMed ID: 31655387   DOI: 10.1016/j.yexmp.2019.104317
10570  Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.  Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.  Osteoarthr. Cartil.  2018  26:108-117  PubMed ID: 29074299   DOI: 10.1016/j.joca.2017.10.011
10670  Liang X, Wang X, Xu Q, Lu Y, Zhang Y, Xia H, Lu A, Zhang L.  Rubbery Chitosan/Carrageenan Hydrogels Constructed through an Electroneutrality System and Their Potential Application as Cartilage Scaffolds.  Biomacromolecules  2018  19:340-352  PubMed ID: 29253344   DOI: 10.1021/acs.biomac.7b01456
10707  Li C, Zheng Z, Zhang X, Asatrian G, Chen E, Song R, Culiat C, Ting K, Soo C.  Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes.  Int J Mol Sci  2018  19:  PubMed ID: 29316655   DOI: 10.3390/ijms19010168
10715  Lin C, Shao Y, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D, Xian CJ.  Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.  J. Cell. Physiol.  2018  233:6135-6147  PubMed ID: 29323710   DOI: 10.1002/jcp.26460
10732  Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.  SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 29402405   DOI: 10.1016/j.bbrc.2018.01.129
10752  Li F, Sun J, Huang S, Su G, Pi G.  LncRNA GAS5 Overexpression Reverses LPS-Induced Inflammatory Injury and Apoptosis Through Up-Regulating KLF2 Expression in ATDC5 Chondrocytes.  Cell. Physiol. Biochem.  2018  45:1241-1251  PubMed ID: 29448248   DOI: 10.1159/000487455
10779  Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.  Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.  Development  2018  145:  PubMed ID: 29511023   DOI: 10.1242/dev.159244
10791  Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.  Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.  J Transl Med  2018  16:72  PubMed ID: 29554973   DOI: 10.1186/s12967-018-1437-3
10793  Matsumoto N, Kaneko M, Watanabe N, Itaoka M, Seki Y, Morimoto T, Torii T, Miyamoto Y, Keiichi Homma , Yamauchi J.  Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation.  Biochem. Biophys. Res. Commun.  2018  499:78-85  PubMed ID: 29567474   DOI: 10.1016/j.bbrc.2018.03.136
10823  Liang Z, Ren C.  Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells.  Biomed. Pharmacother.  2018  103:897-902  PubMed ID: 29710506   DOI: 10.1016/j.biopha.2018.04.085
10843  Yanoshita M, Hirose N, Okamoto Y, Sumi C, Takano M, Nishiyama S, Asakawa-Tanne Y, Horie K, Onishi A, Yamauchi Y, Mitsuyoshi T, Kunimatsu R, Tanimoto K.  Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes.  Inflammation  2018  41(5):1621-1630  PubMed ID: 29737477   DOI: 10.1007/s10753-018-0805-8
11046    Semaphorin 3A inhibits inflammation in chondrocytes under excessive mechanical stress  Mediators of Inflammation  2018  2018, 9  PubMed ID: 29849491   DOI: 10.1155/2018/5703651
11154  Wang Y, Kong D.  MicroRNA-136 promotes lipopolysaccharide-induced ATDC5 cell injury and inflammatory cytokine expression by targeting myeloid cell leukemia 1.  J. Cell. Biochem.  2018  119(11):9316-9326  PubMed ID: 30074264   DOI: 10.1002/jcb.27208
11185  Pan L, Liu D, Zhao L, Wang L, Xin M, Li X.  Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells.  J. Cell. Biochem.  2018  119(12):10165-10175  PubMed ID: 30145831   DOI: 10.1002/jcb.27357
11286  Dong R, Ying J, Xu T, Hu S, Zhang P, Xia C, Fang L, Jin H, Wang P.  Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway.  Evid Based Complement Alternat Med  2018    PubMed ID: 30402118   DOI: 10.1155/2018/2734581
11264  Kudva AK, Luyten FP, Patterson J.  In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells.  Int J Mol Sci  2018    PubMed ID: 30373138   DOI: 10.3390/ijms19113341
11274  Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM.  SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30389141   DOI: 10.1016/j.bbrc.2018.10.167
11305  Pirozzi C, Francisco V, Guida FD, Gómez R, Lago F, Pino J, Meli R, Gualillo O.  Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor.  Cell. Physiol. Biochem.  2018    PubMed ID: 30448827   DOI: 10.1159/000495203
4144  Xu W, Wang Y, Zhao H, Fan B, Guo K, Cai M, Zhang S.  Delta-like 2 negatively regulates chondrogenic differentiation.  J. Cell. Physiol.  2018    PubMed ID: 29057471   DOI: 10.1002/jcp.26244
4145  Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.  Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.  PLoS ONE  2018    PubMed ID: 30281599   DOI: 10.1371/journal.pone.0199856
4146  Nasrabadi D, Rezaeiani S, Sayadmanesh A, Baghaban Eslaminejad M, Shabani A.  Inclusion Body Expression and Refolding of Recombinant Bone Morphogenetic Protein-2.  Avicenna J Med Biotechnol  2018    PubMed ID: 30555651  
4147  Luan L, Liang Z.  Tanshinone IIA protects murine chondrogenic ATDC5 cells from lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-203a.  Biomed. Pharmacother.  2018    PubMed ID: 29679904   DOI: 10.1016/j.biopha.2018.04.051
6644  Yamaguchi K, Asakura K, Imamura M, Kawai G, Sakamoto T, Furihata T, Linhardt RJ, Igarashi K, Toida T, Higashi K.  Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region.  Biochem J  2018  475(23):3797-3812  PubMed ID: 30401686   DOI: 10.1042/BCJ20180672
6643  Wang C, Tan Z, Niu B, Tsang KY, Tai A, Chan WCW, Lo RLK, Leung KKH, Dung NWF, Itoh N, Zhang MQ, Chan D, Cheah KSE.  Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia.  Elife  2018  7. pii: e37673  PubMed ID: 30024379   DOI: 10.7554/eLife.37673
14911  Jung A, Makkar P, Amirian J, Lee BT.  A novel hybrid multichannel biphasic calcium phosphate granule-based composite scaffold for cartilage tissue regeneration  J Biomater Appl  2018  32(6):775-787  PubMed ID: 29130392   DOI: 10.1177/0885328217741757
9829  Jiang M, Fu X, Yang H, Long F, Chen J.  mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.  J. Cell. Biochem.  2017  118:748-753  PubMed ID: 27606668   DOI: 10.1002/jcb.25728
9905  Taniguchi Y, Kawata M, Ho Chang S, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, Saito T.  Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.  Arthritis Rheumatol  2017  69:598-609  PubMed ID: 27792866   DOI: 10.1002/art.39976
10062  Funato S, Yasuhara R, Yoshimura K, Miyamoto Y, Kaneko K, Suzawa T, Chikazu D, Mishima K, Baba K, Kamijo R.  Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner.  Cell Tissue Res.  2017  368:135-144  PubMed ID: 28070636   DOI: 10.1007/s00441-016-2551-2
10105  Le BQ, Vasilevich A, Vermeulen S, Hulshof F, Stamatialis DF, van Blitterswijk CA, de Boer J.  Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line.  Tissue Eng Part A  2017  23:458-469  PubMed ID: 28152670   DOI: 10.1089/ten.TEA.2016.0421
10119  Conde J, Lazzaro V, Scotece M, Abella V, Villar R, López V, Gonzalez-Gay MÁ, Pino J, Gómez R, Mera A, Gualillo O.  Corticoids synergize with IL-1 in the induction of LCN2.  Osteoarthr. Cartil.  2017  25:1172-1178  PubMed ID: 28185846   DOI: 10.1016/j.joca.2017.01.017
10131  Wang CL, Wang H, Xiao F, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li , Yuan-Gao , Zhang XL, Chen XD.  Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.  Biochem. Biophys. Res. Commun.  2017  485:400-408  PubMed ID: 28213129   DOI: 10.1016/j.bbrc.2017.02.065
10273  Quang Le B, Van Blitterswijk C, De Boer J.  An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair.  Bioengineering (Basel)  2017  4:  PubMed ID: 28952514   DOI: 10.3390/bioengineering4020035
10295  Im S, Kim DW.  Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.  Cell. Signal.  2017  36:127-138  PubMed ID: 28479297   DOI: 10.1016/j.cellsig.2017.05.001
10306  Cao L, Zhang F, Wang Q, Wu X.  Fabrication of chitosan/graphene oxide polymer nanofiber and its biocompatibility for cartilage tissue engineering.  Mater Sci Eng C Mater Biol Appl  2017  79:697-701  PubMed ID: 28629070   DOI: 10.1016/j.msec.2017.05.056
10434  Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, Zhang L, Mi M, Chen D, Tong P, Jin H.  Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.  Int. J. Biol. Sci.  2017  13:996-1007  PubMed ID: 28924381   DOI: 10.7150/ijbs.19986
10505  Yuan Y, Tan H, Dai P.  Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13.  Cell. Physiol. Biochem.  2017  42:2159-2168  PubMed ID: 28873368   DOI: 10.1159/000479991
10534  Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A, Cao L.  Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.  Mol Med Rep  2017  16:7679-7684  PubMed ID: 28944864   DOI: 10.3892/mmr.2017.7549
10547  Ji B, Guo W, Ma H, Xu B, Mu W, Zhang Z, Amat A, Cao L.  Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.  Int. J. Mol. Med.  2017  40:1709-1718  PubMed ID: 29039445   DOI: 10.3892/ijmm.2017.3177
10631  Kudo T, Nakatani S, Kakizaki M, Arai A, Ishida K, Wada M, Kobata K.  Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase.  Biol. Pharm. Bull.  2017  40:2075-2080  PubMed ID: 29199232   DOI: 10.1248/bpb.b17-00059
10636  Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T.  Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells.  Sci Rep  2017  7:16701  PubMed ID: 29196633   DOI: 10.1038/s41598-017-16902-4
10651  Taipale M, Solovieva S, Leino-Arjas P, Männikkö M.  Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.  BMC Genet.  2017  18:108  PubMed ID: 29233086   DOI: 10.1186/s12863-017-0585-4
10918    Effects of a Chemically Synthesized Leucine-Rich Amelogenin Peptide (csLRAP) on Chondrogenic and Osteogenic Cells  Journal of Hard Tissue Biology  2017  26, 51- 60    DOI: 10.2485/jhtb.26.51
10986  Yano K, Washio K, Tsumanuma Y, Yamato M, Ohta K, Okano T, Izumi Y.  The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth  Regen Ther  2017  7:98-107  PubMed ID: 30271858   DOI: 10.1016/j.reth.2017.08.001
6635  Seher A, Lagler C, Stühmer T, Müller-Richter UDA, Kübler AC, Sebald W, Müller TD, Nickel J.  Utilizing BMP-2 muteins for treatment of multiple myeloma.  PLoS One  2017  12(5):e0174884  PubMed ID: 28489849   DOI: 10.1371/journal.pone.0174884
6636  Meng X, Cui J, Wang Y, Zhang X, Li D, Hai Y, Du H.  Heterogeneous nuclear ribonucleoprotein A1 interacts with microRNA-34a to promote chondrogenic differentiation of mesenchymal stem cells.  Am J Transl Res  2017  9(4):1774-1782  PubMed ID: 28469782  
6637  Shangguan L, Ning G, Luo Z, Zhou Y  Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/β-catenin signaling.  Int J Biol Macromol  2017  99:293-299  PubMed ID: 28238906   DOI: 10.1016/j.ijbiomac.2017.02.087
6638  Otsuki S, Murakami T, Okamoto Y, Hoshiyama Y, Oda S, Neo M.  Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.  Histol Histopathol  2017  32(7):725-733  PubMed ID: 27808352   DOI: 10.14670/HH-11-838
6639  Ota T, Nishida Y, Ikuta K, Kato R, Kozawa E, Hamada S, Sakai T, Ishiguro N.  Heat-stimuli-enhanced osteogenesis using clinically available biomaterials.  PLoS One  2017  12(7):e0181404  PubMed ID: 28719650   DOI: 10.1371/journal.pone.0181404
14772  神山 伸 他  コラーゲン由来ジペプチドが ATDC5 細胞の軟骨分化と糖鎖合成に及ぼす影響  微量栄養素研究  2017  34:66-73   
7079  Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T, Alswaid A, Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A, Rustad CF, Merckoll E, Westvik J, Stattin EL, Grigelioniene G, Kou I, Nakajima M, Ohashi H, Smithson S, Matsumoto N, Nishimura G, Ikegawa S.  Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.  PLoS ONE  2016  11:e0150555  PubMed ID: 26974433   DOI: 10.1371/journal.pone.0150555
18188  Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R.  High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva  Dis Model Mech  2016  9(6):685-96  PubMed ID: 27125279   DOI: 10.1242/dmm.023929
7124  Staines KA, Prideaux M, Allen S, Buttle DJ, Pitsillides AA, Farquharson C.  E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.  J. Cell. Physiol.  2016  231:1392-404  PubMed ID: 26639105   DOI: 10.1002/jcp.25282
7151  Goto K, Kimura T, Kitamura N, Semba S, Ohmiya Y, Aburatani S, Matsukura S, Tsuda M, Kurokawa T, Ping Gong J, Tanaka S, Yasuda K.  Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.  J Biomed Mater Res A  2016  104:734-746  PubMed ID: 26566602   DOI: 10.1002/jbm.a.35615
7185  Zaman G, Staines KA, Farquharson C, Newton PT, Dudhia J, Chenu C, Pitsillides AA, Dhoot GK.  Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.  Histochem. Cell Biol.  2016  145:67-79  PubMed ID: 26464246   DOI: 10.1007/s00418-015-1365-8
9530  Meng F, Zhang Z, Chen W, Huang G, He A, Hou C, Long Y, Yang Z, Zhang Z, Liao W.  MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses.  Osteoarthr. Cartil.  2016  24:932-41  PubMed ID: 26774733   DOI: 10.1016/j.joca.2015.12.012
9538  Niu Q, Li F, Zhang L, Xu X, Liu Y, Gao J, Feng X.  Role of the Wnt/β-catenin signaling pathway in the response of chondrocytes to mechanical loading.  Int. J. Mol. Med.  2016  37:755-62  PubMed ID: 26821383   DOI: 10.3892/ijmm.2016.2463
9563  Abella V, Scotece M, Conde J, López V, Pirozzi C, Pino J, Gómez R, Lago F, González-Gay MÁ, Gualillo O.  The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.  Sci Rep  2016  6:20356  PubMed ID: 26853108   DOI: 10.1038/srep20356
9567  Saito M, Mulati M, Talib SZ, Kaldis P, Takeda S, Okawa A, Inose H.  The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development.  Sci Rep  2016  6:20622  PubMed ID: 26860366   DOI: 10.1038/srep20622
9645  Caron MM, Emans PJ, Sanen K, Surtel DA, Cremers A, Ophelders D, van Rhijn LW, Welting TJ.  The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells.  PLoS ONE  2016  11:e0153162  PubMed ID: 27050768   DOI: 10.1371/journal.pone.0153162
9648  Pathak JL, Verschueren P, Lems WF, Bravenboer N, Klein-Nulend J, Bakker AD, Luyten FP.  Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells.  Connect. Tissue Res.  2016  57:226-35  PubMed ID: 27050327   DOI: 10.3109/03008207.2016.1146714
9675  Izawa T, Mori H, Shinohara T, Mino-Oka A, Hutami IR, Iwasa A, Tanaka E.  Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis.  PLoS ONE  2016  11:e0154107  PubMed ID: 27123995   DOI: 10.1371/journal.pone.0154107
9682  Shang X, Wang J, Luo Z, Wang Y, Morandi MM, Marymont JV, Hilton MJ, Dong Y.  Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.  Sci Rep  2016  6:25594  PubMed ID: 27146698   DOI: 10.1038/srep25594
9704  Conde J, Otero M, Scotece M, Abella V, López V, Pino J, Gómez R, Lago F, Goldring MB, Gualillo O.  E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.  J. Physiol. (Lond.)  2016  594:6133-6146  PubMed ID: 27222093   DOI: 10.1113/JP272240
9705  Kim H, Park H, Lee JW, Lee KY.  Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.  Carbohydr Polym  2016  151:467-473  PubMed ID: 27474590   DOI: 10.1016/j.carbpol.2016.05.090
9721  Choi HJ, Kwon S, Kim DW.  A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.  Cell. Signal.  2016  28:1336-48  PubMed ID: 27312341   DOI: 10.1016/j.cellsig.2016.06.006
9746  Nakajima M, Kou I, Ohashi H, , Ikegawa S.  Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.  Am. J. Hum. Genet.  2016  99:202-7  PubMed ID: 27374772   DOI: 10.1016/j.ajhg.2016.05.018
9754  Higa K, Kitamura N, Kurokawa T, Goto K, Wada S, Nonoyama T, Kanaya F, Sugahara K, Gong JP, Yasuda K.  Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.  Acta Biomater  2016  43:38-49  PubMed ID: 27427226   DOI: 10.1016/j.actbio.2016.07.023
9768  Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H.  Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.  PLoS ONE  2016  11:e0159375  PubMed ID: 27467521   DOI: 10.1371/journal.pone.0159375
9812  Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Sci Rep  2016  6:31986  PubMed ID: 27558955   DOI: 10.1038/srep31986
9831  Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W.  MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.  Biochim. Biophys. Acta  2016  1863:2881-2891  PubMed ID: 27638301   DOI: 10.1016/j.bbamcr.2016.09.010
9852  Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T.  Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.  Sci Rep  2016  6:33549  PubMed ID: 27650265   DOI: 10.1038/srep33549
9927  Kobayashi H, Chang SH, Mori D, Itoh S, Hirata M, Hosaka Y, Taniguchi Y, Okada K, Mori Y, Yano F, Chung UI, Akiyama H, Kawaguchi H, Tanaka S, Saito T.  Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.  Nat Commun  2016  7:13336  PubMed ID: 27830706   DOI: 10.1038/ncomms13336
9987  Chen Z, Jin T, Lu Y.  AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy.  Cell. Physiol. Biochem.  2016  40:883-894  PubMed ID: 27941314   DOI: 10.1159/000453147
4790  Zhang Y, Dong R2, Park Y1, Bohner M3, Zhang X4, Ting K5, Soo C5, Wu BM6.  Controlled release of NELL-1 protein from chitosan/hydroxyapatite-modified TCP particles.  Int J Pharm  2016  511(1):79-89  PubMed ID: 27349789   DOI: 10.1016/j.ijpharm.2016.06.050
6622  Laurie LE, Kokubo H, Nakamura M, Saga Y, Funato N.  The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.  PLoS One  2016  11(2):e0150263  PubMed ID: 26918743   DOI: 10.1371/journal.pone.0150263
6623  Yang M, Li L, Heo SM, Soh Y.  Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways.  Biomol Ther (Seoul)  2016  24(4):395-401  PubMed ID: 27350340   DOI: 10.4062/biomolther.2016.020
6624  Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K.  R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.  Biochem Biophys Res Commun  2016  473(1):255-264  PubMed ID: 27012200   DOI: 10.1016/j.bbrc.2016.03.089
6625  Cao Z, Dou C, Li J, Tang X, Xiang J, Zhao C2, Zhu L, Bai Y, Xiang Q, Dong S.  Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway.  BMB Rep  2016  49(10):548-553  PubMed ID: 27439604   DOI: 10.5483/bmbrep.2016.49.10.071
6627  Yahara Y et al  Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.  Nat Commun  2016  7:10959  PubMed ID: 27009967   DOI: 10.1038/ncomms10959
6630  Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X.  mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.  Nat Commun  2016  7:11151  PubMed ID: 27039827   DOI: 10.1038/ncomms11151
6631  Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ.  HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.  J Cell Sci  2016  129(11):2145-55  PubMed ID: 27160681   DOI: 10.1242/jcs.181271
6633  Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R.  Correction: High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva.  Dis Model Mech  2016  Sep 1;9(9):1067  PubMed ID: 27604694   DOI: 10.1242/dmm.027573
12634  Chen W, Sheng P, Huang Z, Meng F, Kang Y, Huang G, Zhang Z, Liao W, Zhang Z.  MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression  Int J Mol Sci  2016  17(9):1377  PubMed ID: 27563877   DOI: 10.3390/ijms17091377
12918  Whittaker JL, Dutta NK, Zannettino A, Choudhury NR.  Engineering DN hydrogels from regenerated silk fibroin and poly(N-vinylcaprolactam)  J Mater Chem B  2016  4(33):5519-5533  PubMed ID: 32263350   DOI: 10.1039/c6tb01055e
12950  Chien SY, Huang CY, Tsai CH, Wang SW, Lin YM, Tang CH.  Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes  Clin Sci (Lond)   2016  130(9):667-81  PubMed ID: 26811540   DOI: 10.1042/CS20150622
7192  Naito M, Vongsa S, Tsukune N, Ohashi A, Takahashi T.  Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5.  Mol. Cell. Endocrinol.  2015  417:114-23  PubMed ID: 26419928   DOI: 10.1016/j.mce.2015.09.026
7217  Kim JA, Im S, Cantley LC, Kim DW.  Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.  Cell. Signal.  2015  27:2389-400  PubMed ID: 26363466   DOI: 10.1016/j.cellsig.2015.09.004
7248  Mori H, Izawa T, Tanaka E.  Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.  Am. J. Pathol.  2015  185:2742-56  PubMed ID: 26272361   DOI: 10.1016/j.ajpath.2015.06.015
7279  Hou C, Meng F, Zhang Z, Kang Y, Chen W, Huang G, Fu M, Sheng P, Zhang Z, Liao W.  The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.  Cell. Physiol. Biochem.  2015  36:1753-66  PubMed ID: 26184031   DOI: 10.1159/000430148
7291  Hou C, Zhang Z, Zhang Z, Wu P, Zhao X, Fu M, Sheng P, Kang Y, Liao W.  Presence and function of microRNA-92a in chondrogenic ATDC5 and adipose-derived mesenchymal stem cells.  Mol Med Rep  2015  12:4877-86  PubMed ID: 26135269   DOI: 10.3892/mmr.2015.4008
7329  Santoro A, Conde J, Scotece M, Abella V, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O.  Choosing the right chondrocyte cell line: Focus on nitric oxide.  J. Orthop. Res.  2015  33:1784-8  PubMed ID: 26016689   DOI: 10.1002/jor.22954
7367  Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.  Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.  Histochem. Cell Biol.  2015  144:167-77  PubMed ID: 25929745   DOI: 10.1007/s00418-015-1325-3
7433  Umeda M, Terao F, Miyazaki K, Yoshizaki K, Takahashi I.  MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage.  J. Dent. Res.  2015  94:795-802  PubMed ID: 25784252   DOI: 10.1177/0022034515577411
7450  Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S.  Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.  PLoS ONE  2015  10:e0119177  PubMed ID: 25749104   DOI: 10.1371/journal.pone.0119177
7487  Abella V, Santoro A, Scotece M, Conde J, Lopez-Lopez V, Lazzaro V, Gomez-Reino JJ, Meli R, Gualillo O.  Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.  Toxicol. Lett.  2015  234:13-9  PubMed ID: 25659934   DOI: 10.1016/j.toxlet.2015.02.001
7506  Le BQ, Fernandes H, Bouten CV, Karperien M, van Blitterswijk C, de Boer J.  High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.  Tissue Eng Part C Methods  2015  21:726-36  PubMed ID: 25604243   DOI: 10.1089/ten.TEC.2014.0088
3917  Hutchison MR, White PC.  Prostacyclin regulates bone growth via the Epac/Rap1 pathway.  Endocrinology  2015  156(2):499-510  PubMed ID: 25406016   DOI: 10.1210/en.2014-1348
6005  Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.  Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.  Bone Res  2015  3:15021  PubMed ID: 26558140   DOI: 10.1038/boneres.2015.21
6612  Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung UI, Tanaka S, Saito T.  Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding proteins.  Biomed Res  2015  36(1):21-9  PubMed ID: 25749148   DOI: 10.2220/biomedres.36.21
6613  Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.  GDF-5 can act as a context-dependent BMP-2 antagonist.  BMC Biol  2015  13:77  PubMed ID: 26385096   DOI: 10.1186/s12915-015-0183-8
6614  Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W.  MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.  FEBS Lett  2015  589(23):3671-8  PubMed ID: 26474644   DOI: 10.1016/j.febslet.2015.09.032
6615  Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.  A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.  Sci Signal  2015  8(386):ra71  PubMed ID: 26198357   DOI: 10.1126/scisignal.aaa3792
6616  Nonni Soraya et al  Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineeringcccc  Composites Science and Technology   2015  106:76-84    DOI: 10.1016/j.compscitech.2014.11.003
6617  Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston TN.  Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension.  Elife  2015  4:e09300  PubMed ID: 26652004   DOI: 10.7554/eLife.09300
6620  Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T.  AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.  Bone  2015  74:125-33  PubMed ID: 25497570   DOI: 10.1016/j.bone.2014.12.001
6469  Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.  6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.  Mol Nutr Food Res  2014  58(2):256-66  PubMed ID: 24039109   DOI: 10.1002/mnfr.201200833
3517  Kosaka T, Fukui R, Matsui M, Kurosaka Y, Nishimura H, Tanabe M, Takakura Y, Iwai K, Waki T, Fujita T.  RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.  PLoS One  2014  9(9):e108819  PubMed ID: 25275461   DOI: 10.1371/journal.pone.0108819
6579  Kawamura D, Funakoshi T, Mizumoto S, Sugahara K, Iwasaki N.  Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.  J Orthop Sci  2014  19(6):1028-35  PubMed ID: 25209441   DOI: 10.1007/s00776-014-0643-y
6580  Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K.  Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells.  BMC Musculoskelet Disord  2014  15:222  PubMed ID: 24997593   DOI: 10.1186/1471-2474-15-222
6581  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.  High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.  J Orthop Res  2014  32(12):1619-27  PubMed ID: 25196420   DOI: 10.1002/jor.22691
6583  Nakajima M et al  A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.  Nat Genet  2014  46(9):1012-6  PubMed ID: 25064007   DOI: 10.1038/ng.3045
6584  Suzuki N, Mizuniwa C, Ishii K, Nakagawa Y, Tsuji K, Muneta T, Sekiya I, Akazawa C.  Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.  J Orthop Res  2014  32(7):915-22  PubMed ID: 24648313   DOI: 10.1002/jor.22616
6585  Eijiro Maeda et al  Significant increase in Young׳s modulus of ATDC5 cells during chondrogenic differentiation induced by PAMPS/PDMAAm double-network gel: Comparison with induction by insulin  Journal of Biomechanics  2014  47:3408-3414  PubMed ID: 25110167   DOI: 10.1016/j.jbiomech.2014.07.021
6586  Maenz S, Kunisch E, Mühlstädt M, Böhm A, Kopsch V, Bossert J, Kinne RW, Jandt KD.  Enhanced mechanical properties of a novel, injectable, fiber-reinforced brushite cement.  J Mech Behav Biomed Mater  2014  39:328-38  PubMed ID: 25171749   DOI: 10.1016/j.jmbbm.2014.07.028
6587  Scotece M, Conde J, Abella V, López V, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study.  J Orthop Res  2014  32(5):653-60  PubMed ID: 24464950   DOI: 10.1002/jor.22585
6588  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.  Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.  In Vitro Cell Dev Biol Anim  2014  50(4):358-66  PubMed ID: 24092017   DOI: 10.1007/s11626-013-9692-3
6589  Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.  LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.  Biochem Biophys Res Commun  2014  451(2):302-7  PubMed ID: 25091481   DOI: 10.1016/j.bbrc.2014.07.125
6590  Gómez R, Conde J, Scotece M, López V, Lago F, Gómez Reino JJ, Gualillo O.  Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes.  J Orthop Res  2014  32(9):1137-46  PubMed ID: 24902823   DOI: 10.1002/jor.22660
6591  Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.  S100A1 and S100B are dispensable for endochondral ossification during skeletal development.  Biomed Res  2014  35(4):243-50  PubMed ID: 25152033   DOI: 10.2220/biomedres.35.243
6592  Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.  Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.  PLoS One  2014  9(3):e91421  PubMed ID: 24618907   DOI: 10.1371/journal.pone.0091421
6593  Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K  Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.  J Biol Chem  2014  289(20):13810-20  PubMed ID: 24711445   DOI: 10.1074/jbc.M113.543322
6594  Staines KA, Zhu D, Farquharson C, MacRae VE.  Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.  J Bone Miner Metab  2014  32(3):240-51  PubMed ID: 23925391   DOI: 10.1007/s00774-013-0493-2
6595  Bergmann CJ1, Odekerken JC2, Welting TJ2, Jungwirth F, Devine D3, Bouré L3, Zeiter S3, van Rhijn LW2, Telle R4, Fischer H1, Emans PJ2.  Calcium phosphate based three-dimensional cold plotted bone scaffolds for critical size bone defects.  Biomed Res Int  2014  2014:852610  PubMed ID: 24719891   DOI: 10.1155/2014/852610
6596  Ushijima T, Okazaki K, Tsushima H, Ishihara K, Doi T, Iwamoto Y.  CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.  PLoS One  2014  9(8):e104547  PubMed ID: 25105964   DOI: 10.1371/journal.pone.0104547
6597  Woo E, Park H, Lee KY.  Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.  Macromol Biosci  2014  14(5):740-8  PubMed ID: 24436180   DOI: 10.1002/mabi.201300365
6598  Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT.  Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.  PLoS One  2014  9(3):e92194  PubMed ID: 24637783   DOI: 10.1371/journal.pone.0092194
6599  Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.  Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.  PLoS One  2014  9(3):e92699  PubMed ID: 24658359   DOI: 10.1371/journal.pone.0092699
6600  Hatta T, Kishimoto KN, Okuno H, Itoi E.  Oxygen tension affects lubricin expression in chondrocytes.  Tissue Eng Part A  2014  20(19-20):2720-7  PubMed ID: 24712343   DOI: 10.1089/ten.TEA.2013.0353
6601  Jasmin L. Whittaker a, Namita R. Choudhury, Naba K. Dutta and Andrew Zannettino    J Mater Chem B  2014  2:6259-6270  PubMed ID: 32262143   DOI: 10.1039/C4TB00698D
6602  Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura S.  Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.  Biochim Biophys Acta  2014  1840(1):645-55  PubMed ID: 24161698   DOI: 10.1016/j.bbagen.2013.10.027
6603  Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme NJ, Haines P, Chen Q.  Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells.  Int J Mol Sci  2014  15(8):14555-73  PubMed ID: 25196597   DOI: 10.3390/ijms150814555
6604  Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.  J Biol Chem  2014  89(14):9865-79  PubMed ID: 24563464   DOI: 10.1074/jbc.M113.520585
6605  Inagaki Y, Kitamura N, Kurokawa T, Tanaka Y, Gong JP, Yasuda K, Tohyama H.  Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study.  BMC Musculoskelet Disord  2014  15:320  PubMed ID: 25262146   DOI: 10.1186/1471-2474-15-320
6606  Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.  J Biol Chem  2014  289(12):8135-50  PubMed ID: 24505141   DOI: 10.1074/jbc.M113.509331
6607  Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.  Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.  Neurochem Int  2014  74:24-35  PubMed ID: 24768841   DOI: 10.1016/j.neuint.2014.04.010
6430  Kwon HJ, Ohmiya Y.  Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.  Biomed Res Int  2013  2013:213972  PubMed ID: 23878799   DOI: 10.1155/2013/213972
6464  Gómez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O.  Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes.  J Orthop Res  2013  31(7):1046-52  PubMed ID: 23483583   DOI: 10.1002/jor.22331
6465  Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.  Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.  J Biol Chem  2013  288(40):28620-9  PubMed ID: 23963448   DOI: 10.1074/jbc.M113.452169
6556  Nepal M, Li L, Cho HK, Park JK, Soh Y.  Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway.  Food Chem Toxicol  2013  62:238-45  PubMed ID: 23989061   DOI: 10.1016/j.fct.2013.08.034
6557  Miyatake K, Tsuji K, Yamaga M, Yamada J, Matsukura Y, Abula K, Sekiya I, Muneta T.  Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells.  Biochem Biophys Res Commun  2013  431(1):52-7  PubMed ID: 23291184   DOI: 10.1016/j.bbrc.2012.12.094
6558  Hu-Hui Lee, Jing-Yu Lee & Lan-Hsin   Proper Fhl1 expression as Wnt signaling is required for chondrogenesis of ATDC5 cells  Animal Cells and Systems  2013  17:413-420    DOI: 10.1080/19768354.2013.856341
6559  Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R.  Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.  Cell Tissue Res  2013  352(2):401-12  PubMed ID: 23274552   DOI: 10.1007/s00441-012-1548-8
6560  Mitani K1 Haruyama N, Hatakeyama J, Igarashi K.  Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells.  Oral Dis  2013  19(2):169-79  PubMed ID: 22863294   DOI: 10.1111/j.1601-0825.2012.01967.x
6561  Morimoto H, Baba R, Haneji T, Doi Y.  Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5.  Cell Tissue Res  2013  351(1):41-7  PubMed ID: 23180319   DOI: 10.1007/s00441-012-1521-6
6562  Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.  Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.  J Pharmacol Sci  2013  122(4):318-25  PubMed ID: 23883486   DOI: 10.1254/jphs.13091fp
6563  Yoshikawa K, Kitamura N, Kurokawa T, Gong JP, Nohara Y, Yasuda K.  Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.  BMC Musculoskelet Disord  2013  14:56  PubMed ID: 23379610   DOI: 10.1186/1471-2474-14-56
6564  Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.  Proc Natl Acad Sci U S A  2013  110(5):1875-80  PubMed ID: 23319657   DOI: 10.1073/pnas.1207458110
6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878   DOI: 10.1002/art.37779
6566  Kwon HJ.  ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.  Cell Biochem Funct  2013  31(1):75-81  PubMed ID: 22886426   DOI: 10.1002/cbf.2862
6567  Lambrechts D, Roeffaers M, Kerckhofs G, Roberts SJ, Hofkens J, Van de Putte T, Van Oosterwyck H, Schrooten J.  Fluorescent oxygen sensitive microbead incorporation for measuring oxygen tension in cell aggregates.  Biomaterials  2013  34(4):922-9  PubMed ID: 23122803   DOI: 10.1016/j.biomaterials.2012.10.019
6568  Hall-Glenn F, Aivazi A, Akopyan L, Ong JR, Baxter RR, Benya PD, Goldschmeding R, van Nieuwenhoven FA, Hunziker EB, Lyons KM.  CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress.  J Cell Commun Signal  2013  7(3):219-30  PubMed ID: 23666466   DOI: 10.1007/s12079-013-0201-y
6569  Zheng Z, Ren L, Zhai Z, Wang Y, Hang F.  Surface modification on polyethylene terephthalate films with 2-methacryloyloxyethyl phosphorylcholine.  Mater Sci Eng C Mater Biol Appl  2013  33(5):3041-6  PubMed ID: 23623130   DOI: 10.1016/j.msec.2013.03.036
6570  Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M.  Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.  FEBS Open Bio  2013  3:279-84  PubMed ID: 23905010   DOI: 10.1016/j.fob.2013.07.001
6571  Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.  Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.  Sci Rep  2013  3:3022  PubMed ID: 24149372   DOI: 10.1038/srep03022
6572  Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung UI, Kawaguchi H, Tabin CJ.  SOX11 contributes to the regulation of GDF5 in joint maintenance.  BMC Dev Biol  2013  13:4  PubMed ID: 23356643   DOI: 10.1186/1471-213X-13-4
6573  Uyama T, Inoue M, Okamoto Y, Shinohara N, Tai T, Tsuboi K, Inoue T, Tokumura A, Ueda N.  Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation.  Biochim Biophys Acta  2013  1831(12):1690-701  PubMed ID: 23994608   DOI: 10.1016/j.bbalip.2013.08.017
6575  Hata K, Takashima R, Amano K, Ono K, Nakanishi M, Yoshida M, Wakabayashi M, Matsuda A, Maeda Y, Suzuki Y, Sugano S, Whitson RH, Nishimura R, Yoneda T.  Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.  Nat Commun  2013  4:2850  PubMed ID: 24276541   DOI: 10.1038/ncomms3850
6576  Giacopelli F, Cappato S, Tonachini L, Mura M, Di Lascio S, Fornasari D, Ravazzolo R, Bocciardi R.  Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva.  Orphanet J Rare Dis  2013  8:145  PubMed ID: 24047559   DOI: 10.1186/1750-1172-8-145
7711  Mirza R, Qiao S, Tateyama K, Miyamoto T, Xiuli L, Seo H.  3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.  J. Bone Miner. Metab.  2012  30:144-53  PubMed ID: 21845517   DOI: 10.1007/s00774-011-0303-7
6461  Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes.  PLoS One  2012  7(12):e52533  PubMed ID: 23285079   DOI: 10.1371/journal.pone.0052533
4789  Ohno T, Hashimoto N, Mitsui K, Nishimura H, Hagiwara H.  Iron overload inhibits calcification and differentiation of ATDC5 cells.  J Biochem  2012  151(1):109-14  PubMed ID: 21994951   DOI: 10.1093/jb/mvr124
4882  Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H.  C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.  Hum Mol Genet.   2012  21(5):1111-23  PubMed ID: 22095691   DOI: 10.1093/hmg/ddr540
4922  Newton PT, Staines KA, Spevak L, Boskey AL, Teixeira CC, Macrae VE, Canfield AE, Farquharson C.  Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation.  Int J Mol Med  2012  30(5):1187-93  PubMed ID: 22941229   DOI: 10.3892/ijmm.2012.1114
4939  Kim HR1, Heo YM, Jeong KI Kim YM, Jang HL, Lee KY, Yeo CY, Kim SH, Lee HK, Kim SR, Kim EG, Choi JK.  FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells.  BMB Rep  2012  ;45(5):287-92  PubMed ID: 22617452   DOI: 10.5483/bmbrep.2012.45.5.287
4943  Yamaura K, Akiyama S, Ueno K.  Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cells.  J Cell Biochem  2012  113(3):1054-60  PubMed ID: 22065367   DOI: 10.1002/jcb.23436
4965  Seriwatanachai D, Krishnamra N, Charoenphandhu N.  Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures.  Biochem Biophys Res Commun  2012  420(1):108-13  PubMed ID: 22405773   DOI: 10.1016/j.bbrc.2012.02.123
5029  Kambe Y, Hayashi N, Tomita N.  Adhesive force behavior of single ATDC5 cells in chondrogenic culture.  Biochem Biophys Res Commun  2012  420(2):241-6  PubMed ID: 22425987   DOI: 10.1016/j.bbrc.2012.02.130
5270  Li L, Eun JS, Nepal M, Ryu JH, Cho HK, Choi BY, Soh Y.  Isopsoralen Induces Differentiation of Prechondrogenic ATDC5 Cells via Activation of MAP Kinases and BMP-2 Signaling Pathways.  Biomol Ther (Seoul)  2012  20(3):299-305  PubMed ID: 24130927   DOI: 10.4062/biomolther.2012.20.3.299
5310  Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta  Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.  Nanomedicine (Lond).  2012  7(7):981-93  PubMed ID: 22401267   DOI: 10.2217/nnm.12.1
5318  Gu S, Boyer TG, Naski MC.  Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9.  J Biol Chem.   2012  287(25):21082-92  PubMed ID: 22532563   DOI: 10.1074/jbc.M111.328567
5341  Weiss HE, Roberts SJ, Schrooten J, Luyten FP.  A semi-autonomous model of endochondral ossification for developmental tissue engineering.  Tissue Eng Part A  2012  18(13-14):1334-43  PubMed ID: 22394057   DOI: 10.1089/ten.TEA.2011.0602
5433  Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.  GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.  J Biol Chem  2012  287(35):29227-36  PubMed ID: 22761446   DOI: 10.1074/jbc.M112.372086
6232  Masuda T, Takei N, Nakano T, Anada T, Suzuki O, Arai F.  A microfabricated platform to form three-dimensional toroidal multicellular aggregate.  Biomed Microdevices  2012  14(6):1085-93  PubMed ID: 22996697   DOI: 10.1007/s10544-012-9713-0
6233  Chen CG, Thuillier D, Chin EN, Alliston T.  Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.  Arthritis Rheum  2012  64(10):3278-89  PubMed ID: 22674505   DOI: 10.1002/art.34566
6415  Hou Y, Hu J, Park H, Lee M.  Chitosan-based nanoparticles as a sustained protein release carrier for tissue engineering applications.  J Biomed Mater Res A  2012  100(4):939-47  PubMed ID: 22275184   DOI: 10.1002/jbm.a.34031
6416  Pass C, MacRae VE, Huesa C, Faisal Ahmed S, Farquharson C.  SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.  J Bone Miner Res  2012  27(5):1055-66  PubMed ID: 22228213   DOI: 10.1002/jbmr.1544
6420  Hu J, Hou Y, Park H, Lee M.  Beta-tricalcium phosphate particles as a controlled release carrier of osteogenic proteins for bone tissue engineering.  J Biomed Mater Res A  2012  100(7):1680-6  PubMed ID: 22447727   DOI: 10.1002/jbm.a.34115
6421  Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T.  Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.  J Biol Chem  2012  287(40):33179-90  PubMed ID: 22869368   DOI: 10.1074/jbc.M111.337063
6472  Mitsugi S, Ariyoshi W, Okinaga T, Kaneuji T, Kataoka Y, Takahashi T, Nishihara T.  Mechanisms involved in inhibition of chondrogenesis by activin-A.  Biochem Biophys Res Commun  2012  420(2):380-4  PubMed ID: 22425773   DOI: 10.1016/j.bbrc.2012.03.003
6473  Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P.  New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.  J Bone Miner Res  2012  27(2):429-42  PubMed ID: 21976273   DOI: 10.1002/jbmr.532
6540  Staines KA, Mackenzie NC, Clarkin CE, Zelenchuk L, Rowe PS, MacRae VE, Farquharson C.  MEPE is a novel regulator of growth plate cartilage mineralization.  Bone  2012  51(3):418-30  PubMed ID: 22766095   DOI: 10.1016/j.bone.2012.06.022
6541  Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.  Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.  Biochem J  2012  443(3):789-98  PubMed ID: 22507129   DOI: 10.1042/BJ20112062
6542  Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y.  Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.  J Biol Chem  2012  287(40):33293-303  PubMed ID: 22879594   DOI: 10.1074/jbc.M112.344051
6543  Kawamura I, Maeda S, Imamura K, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.  J Biol Chem  2012  287(34):29101-13  PubMed ID: 22767605   DOI: 10.1074/jbc.M112.349415
6544  Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, Yoneda Y.  Clock genes influence gene expression in growth plate and endochondral ossification in mice.  J Biol Chem  2012  287(43):36081-95  PubMed ID: 22936800   DOI: 10.1074/jbc.M112.408963
6545  Kwon HJ.  TGF-β but not BMP signaling induces prechondrogenic condensation through ATP oscillations during chondrogenesis.  Biochem Biophys Res Commun  2012  424(4):793-800  PubMed ID: 22814106   DOI: 10.1016/j.bbrc.2012.07.041
6546  Zhiwen Zheng et al  Surface characterization of polyethylene terephthalate films treated by ammonia low-temperature plasma  Applied Surface Science  2012  258:7207-7212    DOI: 10.1016/j.apsusc.2012.04.038
6547  Andrés-Bergós J, Tardio L, Larranaga-Vera A, Gómez R, Herrero-Beaumont G, Largo R.  The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo.  J Biol Chem  2012  287(40):33615-28  PubMed ID: 22859309   DOI: 10.1074/jbc.M112.354241
6548  Jundong Shao et al  Early stage structural evolution of PLLA porous scaffolds in thermally induced phase separation process and the corresponding biodegradability and biological property  Polymer Degradation and Stability  2012  97:955-963    DOI: 10.1016/j.polymdegradstab.2012.03.014
6549  Allen JL, Cooke ME, Alliston T.  ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.  Mol Biol Cell  2012  23(18):3731-42  PubMed ID: 22833566   DOI: 10.1091/mbc.E12-03-0172
6550  Hutchison MR.  BDNF alters ERK/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes.  Mol Endocrinol  2012  26(8):1406-16  PubMed ID: 22700586   DOI: 10.1210/me.2012-1063
6551  Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y.  Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.  PLoS One  2012  7(5):e37728  PubMed ID: 22629448   DOI: 10.1371/journal.pone.0037728
6552  Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y, Hinoi E, Yoneda Y.  Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts.  J Cell Physiol  2012  227(10):3477-87  PubMed ID: 22252936   DOI: 10.1002/jcp.24048
6553  Kwon HJ.  Extracellular ATP signaling via P2X(4) receptor and cAMP/PKA signaling mediate ATP oscillations essential for prechondrogenic condensation.  J Endocrinol  2012  214(3):337-48  PubMed ID: 22685336   DOI: 10.1530/JOE-12-0131
7669  Morimoto R, Obinata A.  Overexpression of hematopoietically expressed homeoprotein induces nonapoptotic cell death in mouse prechondrogenic ATDC5 cells.  Biol. Pharm. Bull.  2011  34:1589-95  PubMed ID: 21963500   DOI: 10.1248/bpb.34.1589
7672  Endo T, Kobayashi T.  Thyroid-specific gene expression in chondrocytes.  Biochem. Biophys. Res. Commun.  2011  416:227-31  PubMed ID: 21945616   DOI: 10.1016/j.bbrc.2011.08.122
7760  Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Saamanen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.  Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.  J. Biol. Chem.  2011  286:32140-9  PubMed ID: 21724852   DOI: 10.1074/jbc.M111.230110
7786  Yan C, Wang Y, Shen XY, Yang G, Jian J, Wang HS, Chen GQ, Wu Q.  MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates.  Biomaterials  2011  32:6435-44  PubMed ID: 21665270   DOI: 10.1016/j.biomaterials.2011.05.031
7805  Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C.  Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.  J. Bone Miner. Res.  2011  26:1230-41  PubMed ID: 21611965   DOI: 10.1002/jbmr.314
7861  Morimoto R, Yamamoto A, Akimoto Y, Obinata A.  Homeoprotein Hex is expressed in mouse developing chondrocytes.  J. Biochem.  2011  150:61-71  PubMed ID: 21454303   DOI: 10.1093/jb/mvr039
7887  Yang CL, Chen HW, Wang TC, Wang YJ.  A novel fibrin gel derived from hyaluronic acid-grafted fibrinogen.  Biomed Mater  2011  6:025009  PubMed ID: 21393811   DOI: 10.1088/1748-6041/6/2/025009
7902  Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.  Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.  J. Biol. Chem.  2011  286:14744-52  PubMed ID: 21372137   DOI: 10.1074/jbc.M111.221259
7908  Shimada H, Sakakima H, Tsuchimochi K, Matsuda F, Komiya S, Goldring MB, Ijiri K.  Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice.  Pathol. Res. Pract.  2011  207:225-31  PubMed ID: 21353395   DOI: 10.1016/j.prp.2011.01.007
7912  Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.  Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.  Mol. Biol. Cell  2011  22:1300-11  PubMed ID: 21346191   DOI: 10.1091/mbc.E10-07-0566
7946  Takeshita N, Yoshimi E, Hatori C, Kumakura F, Seki N, Shimizu Y.  Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.  J. Pharmacol. Sci.  2011  115:481-9  PubMed ID: 21325780   DOI: 10.1254/jphs.10319fp
7962  Yoon HE, Kim KS, Kim IY.  14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell.  Biochem. Biophys. Res. Commun.  2011  406:59-63  PubMed ID: 21291861   DOI: 10.1016/j.bbrc.2011.01.107
7975  Choi HJ, Nepal M, Park YR, Lee HK, Oh SR, Soh Y.  Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin.  Eur. J. Pharmacol.  2011  655:9-15  PubMed ID: 21266170   DOI: 10.1016/j.ejphar.2011.01.012
8000  Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C, Gomez-Reino J, Lago F, Gualillo O.  Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes.  Ann. Rheum. Dis.  2011  70:551-9  PubMed ID: 21216818   DOI: 10.1136/ard.2010.132399
8062  Nakajima M, Miyamoto Y, Ikegawa S.  Cloning and characterization of the osteoarthritis-associated gene DVWA.  J. Bone Miner. Metab.  2011  29:300-8  PubMed ID: 21057832   DOI: 10.1007/s00774-010-0230-z
4791  Nishimura I, Chano T, Kita H, Matsusue Y, Okabe H.  RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.  J Biol Chem  2011  286(51):43925-32  PubMed ID: 22049074   DOI: 10.1074/jbc.M111.264192
4864  Kutsuna T, Inoue H, Takeda H, Takahashi T, Yamamoto H, Miura H, Higashiyama S.  Fibronectin regulates proteoglycan production balance in transforming growth factor-β1-induced chondrogenesis.  Int J Mol Med.  2011  28(5):829-34  PubMed ID: 21822533   DOI: 10.3892/ijmm.2011.766
8122  Choi BH, Choi YS, Kang DG, Kim BJ, Song YH, Cha HJ.  Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.  Biomaterials  2010  31:8980-8  PubMed ID: 20832110   DOI: 10.1016/j.biomaterials.2010.08.027
8222  Huang BL, Brugger SM, Lyons KM.  Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.  J. Biol. Chem.  2010  285:27702-12  PubMed ID: 20571031   DOI: 10.1074/jbc.M110.108498
8241  Temu TM, Wu KY, Gruppuso PA, Phornphutkul C.  The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.  Am. J. Physiol. Endocrinol. Metab.  2010  299:E325-34  PubMed ID: 20530736   DOI: 10.1152/ajpendo.00145.2010
8308  Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.  Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.  J. Bone Miner. Metab.  2010  28:627-33  PubMed ID: 20376510   DOI: 10.1007/s00774-010-0179-y
8343  Iacono A, Gomez R, Sperry J, Conde J, Bianco G, Meli R, Gomez-Reino JJ, Smith AB 3rd, Gualillo O.  Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line.  Arthritis Rheum.  2010  62:1675-82  PubMed ID: 20201078   DOI: 10.1002/art.27437
8347  Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.  Arthritis Rheum.  2010  62:826-36  PubMed ID: 20187155   DOI: 10.1002/art.27296
8353  Shirakura M, Tanimoto K, Eguchi H, Miyauchi M, Nakamura H, Hiyama K, Tanimoto K, Tanaka E, Takata T, Tanne K.  Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.  Biochem. Biophys. Res. Commun.  2010  393:800-5  PubMed ID: 20171183   DOI: 10.1016/j.bbrc.2010.02.086
8355  Kushibiki T, Tajiri T, Ninomiya Y, Awazu K.  Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation.  J. Photochem. Photobiol. B, Biol.  2010  98:211-5  PubMed ID: 20163967   DOI: 10.1016/j.jphotobiol.2010.01.008
8363  Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.  Increased expression of the hedgehog signaling pathway in pediatric solid malignancies.  J. Pediatr. Surg.  2010  45:387-92  PubMed ID: 20152358   DOI: 10.1016/j.jpedsurg.2009.10.081
8399  Noguchi K, Watanabe Y, Fuse T, Takizawa M.  A new chondrogenic differentiation initiator with the ability to up-regulate SOX trio expression.  J. Pharmacol. Sci.  2010  112:89-97  PubMed ID: 20051655   DOI: 10.1254/jphs.09254fp
8425  Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A.  Fibulin-3 negatively regulates chondrocyte differentiation.  Biochem. Biophys. Res. Commun.  2010  391:1116-21  PubMed ID: 20005202   DOI: 10.1016/j.bbrc.2009.12.034
8450  Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y.  Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.  Calcif. Tissue Int.  2010  86:47-57  PubMed ID: 19921088   DOI: 10.1007/s00223-009-9311-1
4605  Kwon HJ, Yasuda K, Ohmiya Y, Honma K, Chen YM, Gong JP.  In vitro differentiation of chondrogenic ATDC5 cells is enhanced by culturing on synthetic hydrogels with various charge densities.  Acta Biomater  2010  6(2):494-501  PubMed ID: 19651251   DOI: 10.1016/j.actbio.2009.07.033
4608  Takayama Y, Mizumachi K.  Inhibitory effect of lactoferrin on hypertrophic differentiation of ATDC5 mouse chondroprogenitor cells.  Biometals  2010  23(3):477-84  PubMed ID: 20094900   DOI: 10.1007/s10534-010-9291-7
4655  Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.  Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.  Int J Mol Med  2010  25(4):593-600  PubMed ID: 20198308   DOI: 10.3892/ijmm_00000381
4665  Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.  Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.  Nat Med  2010  16(6):678-86  PubMed ID: 20495570   DOI: 10.1038/nm.2146
4666  Yuan Li, Naoki Matsuda, Xu Xu Bao, Akira Teramoto, Koji Abe  The Development of Gelatin/Chitosan Hybrid Scaffold for Mouse Embryonic Stem Cell Line ATDC5  Advanced Materials Research  2010  123-125:395-398    DOI: 10.4028/www.scientific.net/AMR.123-125.395
4669  Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A.  The cleavage of N-cadherin is essential for chondrocyte differentiation.  Biochem Biophys Res Commun  2010  400(4):493-9  PubMed ID: 20735983   DOI: 10.1016/j.bbrc.2010.08.070
4678  Hutchison MR1, Bassett MH, White PC.  SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation.  Mol Endocrinol  2010  24(1):193-203  PubMed ID: 19897599   DOI: 10.1210/me.2009-0228
4679  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257   DOI: 10.1242/jcs.071373
8500  Owen HC, Ahmed SF, Farquharson C.  Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo.  Calcif. Tissue Int.  2009  85:326-34  PubMed ID: 19727539   DOI: 10.1007/s00223-009-9276-0
8545  Ti?li RS, Gumu?derelio?lu M.  Chondrogenesis on BMP-6 loaded chitosan scaffolds in stationary and dynamic cultures.  Biotechnol. Bioeng.  2009  104:601-10  PubMed ID: 19575410   DOI: 10.1002/bit.22426
8555  Nakajima S, Naruto T, Miyamae T, Imagawa T, Mori M, Nishimaki S, Yokota S.  Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells.  Cytokine  2009  47:91-7  PubMed ID: 19535264   DOI: 10.1016/j.cyto.2009.05.002
8559  Kishimoto KN, Oxford CL, Reddi AH.  Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia.  Cell Biol. Int.  2009  33:1222-9  PubMed ID: 19524690   DOI: 10.1016/j.cellbi.2009.06.009
8568  Gomez R, Lago F, Gomez-Reino JJ, Dieguez C, Gualillo O.  Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes.  Arthritis Rheum.  2009  60:1704-9  PubMed ID: 19479831   DOI: 10.1002/art.24522
8608  Gevers EF, Hannah MJ, Waters MJ, Robinson IC.  Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.  Endocrinology  2009  150:3627-36  PubMed ID: 19359380   DOI: 10.1210/en.2008-0985
8636  Nakamura Y, Takarada T, Kodama A, Hinoi E, Yoneda Y.  Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.  J. Pharmacol. Sci.  2009  109:413-23  PubMed ID: 19270431   DOI: 10.1254/jphs.08315fp
8646  Hayashida M, Okazaki K, Fukushi J, Sakamoto A, Iwamoto Y.  CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.  Arthritis Rheum.  2009  60:708-16  PubMed ID: 19248099   DOI: 10.1002/art.24332
8651  Kotzsch A, Nickel J, Seher A, Sebald W, Muller TD.  Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.  EMBO J.  2009  28:937-47  PubMed ID: 19229295   DOI: 10.1038/emboj.2009.37
8678  Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A.  A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification.  Arch. Histol. Cytol.  2009  72:175-85  PubMed ID: 20513980   DOI: 10.1679/aohc.72.175
8706  Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y.  A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect.  Macromol Biosci  2009  9:307-16  PubMed ID: 19031389   DOI: 10.1002/mabi.200800223
8713  Ti?li RS, Gumu?derelio?lu M.  Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds.  J Mater Sci Mater Med  2009  20:699-709  PubMed ID: 18987950   DOI: 10.1007/s10856-008-3624-x
6520  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C.  Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.  Am J Physiol Endocrinol Metab  2009  296(6):E1374-82  PubMed ID: 19401455   DOI: 10.1152/ajpendo.91018.2008
6531  Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.  Arthritis Rheum  2009  60(11):3314-23  PubMed ID: 19877062   DOI: 10.1002/art.24878
6532  Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung U, Nakamura K, Kawaguchi H.  Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.  Osteoarthritis Cartilage  2009  17(8):1065-75  PubMed ID: 19254740   DOI: 10.1016/j.joca.2009.02.003
6533  Arthritis Rheum  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917   DOI: 10.1002/art.24243
6534  Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A.  Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.  J Cell Biochem  2009  106(4):580-8  PubMed ID: 19142862   DOI: 10.1002/jcb.22029
6535  Heinecke K, Seher A, Schmitz W, Mueller TD, Sebald W, Nickel J.  Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.  BMC Biol  2009  7:59  PubMed ID: 19735544   DOI: 10.1186/1741-7007-7-59
6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746   DOI: 10.1186/1471-213X-9-70
6537  Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K. Author information  Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.  Nat Cell Biol  2009  11(10):1197-204  PubMed ID: 19767744   DOI: 10.1038/ncb1962
6538  Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T.  Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.  Mol Biol Cell  2009  20(21):4541-51  PubMed ID: 19759178   DOI: 10.1091/mbc.e09-03-0227
6539  Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C.  Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.  J Cell Physiol  2009  218(2):276-84  PubMed ID: 18803233   DOI: 10.1002/jcp.21593
8784  Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  FEBS J.  2008  275:172-83  PubMed ID: 18070108   DOI: 10.1111/j.1742-4658.2007.06187.x
6510  Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y.  Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.  Genes Cells  2008  13(4):355-63  PubMed ID: 18363966   DOI: 10.1111/j.1365-2443.2008.01170.x
6511  Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.  A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.  J Mol Biol  2008  381(4):1025-39  PubMed ID: 18621057   DOI: 10.1016/j.jmb.2008.06.074
6512  Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O.  Development of a cell culture system loading cyclic mechanical strain to chondrogenic cells.  J Biotechnol  2008  133(2):231-8  PubMed ID: 17904677   DOI: 10.1016/j.jbiotec.2007.08.007
6513  Galal N, El Beialy W, Deyama Y, Yoshimura Y, Yoshikawa T, Suzuki K, Totsuka Y.  Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements.  Int J Mol Med  2008  21(6):785-90  PubMed ID: 18506373  
6514  Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.  Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.  J Biol Chem  2008  283(39):26499-508  PubMed ID: 18632667   DOI: 10.1074/jbc.M800933200
6515  Tanne Y, Tanimoto K, Tanaka N, Ueki M, Lin YY, Ohkuma S, Kamiya T, Tanaka E, Tanne K.  Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation.  Arch Oral Biol  2008  53(5):478-87  PubMed ID: 18242579   DOI: 10.1016/j.archoralbio.2007.12.007
6516  Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T.  Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.  Osteoarthritis Cartilage  2008  16(6):723-32  PubMed ID: 18226559   DOI: 10.1016/j.joca.2007.10.014
6517  Takarada T, Hinoi E, Takahata Y, Yoneda Y.  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.  J Cell Physiol  2008  215(2):320-8  PubMed ID: 17929246   DOI: 10.1002/jcp.21310
6518  Roberts SJ, Owen HC, Farquharson C.  Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.  Biochem Biophys Res Commun  2008  371(4):872-6  PubMed ID: 18471996   DOI: 10.1016/j.bbrc.2008.04.163
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373
6521  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.  Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.  J Biol Chem  2008  283(36):24682-9  PubMed ID: 18617520   DOI: 10.1074/jbc.M709857200
6522  Schugar RC, Robbins PD, Deasy BM.  Small molecules in stem cell self-renewal and differentiation.  Gene Ther  2008  15(2):126-35  PubMed ID: 17989703   DOI: 10.1038/sj.gt.3303062
6523  Tiğli RS, Gümüşderelioğlu M.  Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity.  Int J Biol Macromol  2008  43(2):121-8  PubMed ID: 18485469   DOI: 10.1016/j.ijbiomac.2008.04.003
6524  Owen HC, Roberts SJ, Ahmed SF, Farquharson C.  Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.  Am J Physiol Endocrinol Metab  2008  294(6):E1023-34  PubMed ID: 18381927   DOI: 10.1152/ajpendo.00586.2007
12384  Boileau C, Poirier F, Pelletier JP, Guévremont M, Duval N, Martel-Pelletier J, Reboul P.  Intracellular localisation of galectin-3 has a protective role in chondrocyte survival  Ann Rheum Dis  2008  67(2):175-81  PubMed ID: 17545192   DOI: 10.1136/ard.2006.066514
18910  Dadsetan M, Szatkowski JP, Yaszemski MJ, Lu L.  Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering  Biomacromolecules  2007  8(5):1702-9  PubMed ID: 17419584   DOI: 10.1021/bm070052h
3584  Muramatsu S, Wakabayashi M, Ohno T, Amano K, Ooishi R, Sugahara T, Shiojiri S, Tashiro K, Suzuki Y, Nishimura R, Kuhara S, Sugano S, Yoneda T, Matsuda A.  Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.  J Biol Chem  2007  282(44):32158-67  PubMed ID: 17804410   DOI: 10.1074/jbc.M706158200
6167  Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH.  Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.  Dev Dyn  2007  236(5):1313-8  PubMed ID: 17436279   DOI: 10.1002/dvdy.21137
6494  Nakatani S, Mano H, Im R, Shimizu J, Wada M.  Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5.  Biol Pharm Bull  2007  30(3):433-8  PubMed ID: 17329833   DOI: 10.1248/bpb.30.433
6495  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.  The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.  Biomaterials  2007  28(3):434-40  PubMed ID: 16978693   DOI: 10.1016/j.biomaterials.2006.08.050
6496  Narukawa M, Suzuki N, Takayama T, Shoji T, Otsuka K, Ito K.  Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells.  J Periodontal Res  2007  42(2):131-7  PubMed ID: 17305871   DOI: 10.1111/j.1600-0765.2006.00926.x
6497  Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.  Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.  Biochim Biophys Acta  2007  1774(9):1108-17  PubMed ID: 17669701   DOI: 10.1016/j.bbapap.2007.06.005
6498  Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S.  Mechanisms for asporin function and regulation in articular cartilage.  J Biol Chem  2007  282(44):32185-92  PubMed ID: 17827158   DOI: 10.1074/jbc.M700522200
6499  Macrae VE, Ahmed SF, Mushtaq T, Farquharson C.  IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.  Growth Horm IGF Res  2007  17(5):435-9  PubMed ID: 17590365   DOI: 10.1016/j.ghir.2007.05.002
6500  Hinoi E, Takarada T, Fujimori S, Wang L, Iemata M, Uno K, Yoneda Y.  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.  Bone  2007  40(2):337-44  PubMed ID: 17029980   DOI: 10.1016/j.bone.2006.08.016
6501  Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.  Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.  Dev Biol  2007  312(2):572-81  PubMed ID: 17997399   DOI: 10.1016/j.ydbio.2007.10.001
6502  Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.  Novel function of TWEAK in inducing intervertebral disc degeneration.  J Orthop Res  2007  25(11):1438-46  PubMed ID: 17568422   DOI: 10.1002/jor.20445
6503  Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA.  Regulation of the human SOX9 promoter by Sp1 and CREB.  Exp Cell Res  2007  313(6):1069-79  PubMed ID: 17289023   DOI: 10.1016/j.yexcr.2007.01.001
6504  Owen HC, Miner JN, Ahmed SF, Farquharson C.  The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.  Mol Cell Endocrinol  2007  264(1-2):164-70  PubMed ID: 17182172   DOI: 10.1016/j.mce.2006.11.006
6505  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Identification and characterization of the human SOX6 promoter.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257   DOI: 10.1016/j.bbrc.2007.03.133
6506  Huang BL, Dornbach LM, Lyons KM.  The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.  J Cell Commun Signal  2007  1(1):17-32  PubMed ID: 18481207   DOI: 10.1007/s12079-007-0003-1
6507  Takeuchi S, Mukai N, Tateishi T, Miyakawa S.  Production of sex steroid hormones from DHEA in articular chondrocyte of rats.  Am J Physiol Endocrinol Metab  2007  293(1):E410-5  PubMed ID: 17473054   DOI: 10.1152/ajpendo.00042.2007
6509  Ishii I, Mizuta H, Sei A, Hirose J, Kudo S, Hiraki Y.  Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.  J Bone Joint Surg Br  2007  89(5):693-700  PubMed ID: 17540759   DOI: 10.1302/0301-620X.89B5.18450
4863  Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.  Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5.  J Bone Miner Metab  2006  24(2):153-7  PubMed ID: 16502123   DOI: 10.1007/s00774-005-0662-z
6478  Nakatani S, Mano H, Ryanghyok IM, Shimizu J, Wada M.  Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.  Biochem Biophys Res Commun  2006  348(3):1157-62  PubMed ID: 16904632   DOI: 10.1016/j.bbrc.2006.07.180
6479  Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.  The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.  Calcif Tissue Int  2006  78(3):171-7  PubMed ID: 16523220   DOI: 10.1007/s00223-005-1233-y
6481  Reinhold MI, Kapadia RM, Liao Z, Naski MC.  The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis.  J Biol Chem  2006  281(3):1381-8  PubMed ID: 16293629   DOI: 10.1074/jbc.M504875200
6482  Kanda Y1, Hisayasu S, Fukai F, Takase B.  Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms.  Life Sci  2006  78(6):640-8  PubMed ID: 16111716   DOI: 10.1016/j.lfs.2005.05.081
6483  Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, Ikegawa S.  Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene.  Biochem Biophys Res Commun  2006  341(1):121-7  PubMed ID: 16413503   DOI: 10.1016/j.bbrc.2005.12.159
6484  Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.  Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.  Eur J Pharmacol  2006  542(1-3):48-53  PubMed ID: 16828741   DOI: 10.1016/j.ejphar.2006.06.006
6485  Stewart AJ, Houston B, Farquharson C.  Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.  J Cell Physiol  2006  206(2):435-40  PubMed ID: 16155924   DOI: 10.1002/jcp.20481
6486  Phornphutkul C, Wu KY, Gruppuso PA.  The role of insulin in chondrogenesis.  Mol Cell Endocrinol  2006  249(1-2):107-15  PubMed ID: 16530934   DOI: 10.1016/j.mce.2006.02.002
6487  Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y.  Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.  J Biol Chem  2006  281(33):23632-42  PubMed ID: 16777848   DOI: 10.1074/jbc.M512362200
6488  Chen L, Fink T, Ebbesen P, Zachar V.  Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions.  Tissue Eng  2006  12(3):559-67  PubMed ID: 16579689   DOI: 10.1089/ten.2006.12.559
6489  Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A.  TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.  Arthritis Res Ther  2006  8(5):R146  PubMed ID: 16945157   DOI: 10.1186/ar2038
6490  Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.  Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.  J Biol Chem  2006  281(37):27229-41  PubMed ID: 16835229   DOI: 10.1074/jbc.M603385200
6491  MacRae VE, Farquharson C, Ahmed SF.  The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.  J Endocrinol  2006  189(2):319-28  PubMed ID: 16648299   DOI: 10.1677/joe.1.06609
6492  MacRae VE, Burdon T, Ahmed SF, Farquharson C.  Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.  J Endocrinol  2006  191(2):369-77  PubMed ID: 17088406   DOI: 10.1677/joe.1.06958
6976  Nagai N, Anzawa T, Satoh Y, Suzuki T, Tajima K, Munekata M.  Activities of MC3T3-E1 cells cultured on gamma-irradiated salmon atelocollagen scaffold.  J Biosci Bioeng  2006  101(6):511-4  PubMed ID: 16935254   DOI: 10.1263/jbb.101.511
2874  Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Biochem Biophys Res Commun  2005  333:1300-8  PubMed ID: 15979579   DOI: 10.1016/j.bbrc.2005.06.041
3120  Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446   DOI: 10.1007/s11010-005-8159-6
3194  Hinoi E, Wang L, Takemori A, Yoneda Y.  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296   DOI: 10.1016/j.bcp.2005.04.025
5399  Takumi Tamayama, Kentaro Maemura, Kiyoto Kanbara,Hana Hayasaki, Yasuaki Yabumoto, Masayoshi Yuasa,and Masahito Watanabe  Expression of GABAAand GABABreceptorsin rat growth plate chondrocytes: Activationof the GABA receptors promotes proliferationof mouse chondrogenic ATDC5 cells  Molecular and Cellular Biochemistry  2005  273:117–126   
4989  Kirimoto A1, Takagi Y, Ohya K, Shimokawa H.  Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5.  J Med Dent Sci  2005  52(3):153-62  PubMed ID: 16350840  
5412  Chen L, Fink T, Zhang XY, Ebbesen P, Zachar V.  Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis.  Differentiation  2005  73(7):350-63  PubMed ID: 16219039   DOI: 10.1111/j.1432-0436.2005.00038.x
5972  Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R.  Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.  Biochem J  2005  389(Pt 2):315-23  PubMed ID: 15784009   DOI: 10.1042/BJ20041996
6221  Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.  Hum Mol Genet  2005  14(8):1009-17  PubMed ID: 15746150   DOI: 10.1093/hmg/ddi093
6230  Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.  Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.  J Cell Physiol  2005  204(3):927-33  PubMed ID: 15795936   DOI: 10.1002/jcp.20350
6245  Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K.  Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.  Exp Cell Res  2005  310(2):256-69  PubMed ID: 16165127   DOI: 10.1016/j.yexcr.2005.07.025
4968  Okada A, Shiomi T, Aoki Y, Fujiwara M.  Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.  J Toxicol Sci  2005  30(3):145-56  PubMed ID: 16141649   DOI: 10.2131/jts.30.145
6222  Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P.  GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton.  Bone  2005  37(2):139-47  PubMed ID: 15946906   DOI: 10.1016/j.bone.2005.04.015
6871  Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG.  Regulation of the human Sox9 promoter by the CCAAT-binding factor.  Matrix Biol   2005  24(3):185-97  PubMed ID: 15908194   DOI: 10.1016/j.matbio.2005.04.001
3158  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495   DOI: 10.1016/j.yexcr.2003.12.018
2899  Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  J Cell Biol  2004  166:85-95  PubMed ID: 15226309   DOI: 10.1083/jcb.200401138
2926  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410   DOI: 10.1016/S0002-9440(10)63348-2
2900  Nakajima M, Negishi Y, Tanaka H, Kawashima K.  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198   DOI: 10.1016/j.bbrc.2004.06.057
3330  Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Molecular recognition of BMP-2 and BMP receptor IA.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755   DOI: 10.1038/nsmb756
6247  Fujita T, Fukuyama R, Enomoto H, Komori T.  Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.  J Cell Biochem  2004  93(2):374-83  PubMed ID: 15368363   DOI: 10.1002/jcb.20192
6294  Yamagiwa H, Yamada Y, Bolander ME, Sarkar G.  Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell.  Mol Biotechnol  2004  28(1):1-8  PubMed ID: 15456958   DOI: 10.1385/MB:28:1:01
6306  Madhavi Ayyalasomayajula , Sydha Salihu , Vincent Kish , Nilay Mukherjee  Influence of Rearrangement of Actin Cytoskeleton on the Overall Material Properties of ATDC5 Cells During Chondrogenesis  Advances in Bioengineering  2004  359-360    DOI: 10.1115/IMECE2004-61286
6345  Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F.  Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.  Biochem Biophys Res Commun  2004  315(2):272-80  PubMed ID: 14766204   DOI: 10.1016/j.bbrc.2004.01.048
6373  Yamagiwa H, Bolander ME, Sarkar G.  Evaluation of different conditions for ligating dumbbell-shaped oligonucleotides.  Mol Biotechnol  2004  26(2):111-6  PubMed ID: 14764936   DOI: 10.1385/MB:26:2:111
6375  Jayendran Srinivasan , Vincent Kish , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  Poking Cells in Cell-Gel Constructs: A Potential Way of Measuring Fluid Pressure in Cells  Advances in Bioengineering  2004  361-362    DOI: 10.1115/IMECE2004-61290
3591  Hidaka K, Kanematsu T, Caffrey JJ, Takeuchi H, Shears SB, Hirata M.  The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.  Exp Cell Res  2003  290(2):254-64  PubMed ID: 14567985   DOI: 10.1016/s0014-4827(03)00337-9
3549  Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y.  PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.  J Bone Miner Res  2003  18(8):1395-403  PubMed ID: 12929929   DOI: 10.1359/jbmr.2003.18.8.1395
4777  Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Kim HJ, Ryoo HM.  BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.  J Biol Chem  2003  278(36):34387-94. Epub 2003 Jun 18  PubMed ID: 12815054   DOI: 10.1074/jbc.M211386200
4820  Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K.  Suppression of differentiation and proliferation of early chondrogenic cells by Notch.  J Bone Miner Metab  2003  21(6):344-52  PubMed ID: 14586790   DOI: 10.1007/s00774-003-0428-4
4874  Nishiyama T, Hatano H, Kurosaka M, Bolander ME, Sarkar G.  Cis-acting intronic elements that regulate cartilage-specific alternative splicing of the type II collagen (Col2) pre-mRNA lie at or near splice site junction sequences flanking exon 2 of the gene.  J Bone Miner Res  2003  18(9):1716-22  PubMed ID: 12968682   DOI: 10.1359/jbmr.2003.18.9.1716
4908  Shinsuke Aoki et al  A new approach to an artificial joint based on bio-cartilage/porous β-tricalcium phosphate system  Journal of the European Ceramic Society  2003  23:2939-2946    DOI: 10.1016/S0955-2219(03)00305-4
4937  Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung UI, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H.  Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.  J Biol Chem  2003  278(48):48259-66  PubMed ID: 13679380   DOI: 10.1074/jbc.M211639200
4944  Oda R, Suardita K, Fujimoto K, Pan H, Yan W, Shimazu A, Shintani H, Kato Y.  Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.  J Cell Sci  2003  116(Pt 10):2029-38  PubMed ID: 12679380   DOI: 10.1242/jcs.00393
4978  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046   DOI: 10.1016/j.bbrc.2003.08.058
3555  Nishigaki F, Sakuma S, Ogawa T, Miyata S, Ohkubo T, Goto T.  FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5.  Eur J Pharmacol  2002  437(3):123-8  PubMed ID: 11890899   DOI: 10.1016/s0014-2999(02)01269-4
3556  Suda M, Tanaka K, Yasoda A, Komatsu Y, Chusho H, Miura M, Tamura N, Ogawa Y, Nakao K.  C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line.  J Bone Miner Metab  2002  20(3):136-41  PubMed ID: 11984695   DOI: 10.1007/s007740200019
3558  Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y.  Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.  J Biol Chem  2002  277(51):50112-20  PubMed ID: 12384505   DOI: 10.1074/jbc.M206771200
3560  Fujita T, Meguro T, Fukuyama R, Nakamuta H, Koida M.  New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.  J Biol Chem  2002  277(25):22191-200  PubMed ID: 11956184   DOI: 10.1074/jbc.M110364200
3561  Jayendran Srinivasan , Vincent Kish , Vidyashankar Venkatesan , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  Material Properties of Cells Can Be Determined From Compression Experiments of Cell-Gel Constructs  ASME 2002 International Mechanical Engineering Congress and Exposition  2002  47-48    DOI: 10.1115/IMECE2002-32664
3563  Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H.  Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10.  J Biol Chem  2002  277(9):7493-500  PubMed ID: 11741978   DOI: 10.1074/jbc.M108653200
3566  Suardita K, Fujimoto K, Oda R, Shimazu A, Miyazaki K, Kawamoto T, Kato Y.  Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in Vitro.  J Biol Chem  2002  277(50):48579-86  PubMed ID: 12374788   DOI: 10.1074/jbc.M209243200
3568  Ganss B, Kobayashi H.  The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation.  J Bone Miner Res  2002  17(12):2151-60  PubMed ID: 12469909   DOI: 10.1359/jbmr.2002.17.12.2151
3569  Hatano H, Sarkar G, Bolander ME.  Development of a cellular model to study alternative splicing of type II collagen gene.  J Orthop Res  2002  0(3):516-9  PubMed ID: 12038625   DOI: 10.1016/S0736-0266(01)00123-1
3570  Shiroki K, Ohsawa C, Sugi N, Wakiyama M, Miura K, Watanabe M, Suzuki Y, Sugano S.  Internal ribosome entry site-mediated translation of Smad5 in vivo: requirement for a nuclear event.  Nucleic Acids Res  2002  30(13):2851-61  PubMed ID: 12087169   DOI: 10.1093/nar/gkf408
2487  Fujita T, Izumo N, Fukuyama R, Meguro T, Nakamuta H, Kohno T, Koida M  Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cells.  Biochem Biophys Res Commun  2001  280:348-52  PubMed ID: 11162521   DOI: 10.1006/bbrc.2000.4108
2488  Fujita T, Meguro T, Izumo N, Yasutomi C, Fukuyama R, Nakamuta H, Koida M  Phosphate stimulates differentiation and mineralization of the chondroprogenitor clone ATDC5.  Jpn J Pharmacol  2001  85:278-81  PubMed ID: 11325020   DOI: 10.1254/jjp.85.278
5978  Shen M, Kawamoto T, Teramoto M, Makihira S, Fujimoto K, Yan W, Noshiro M, Kato Y.  Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.  Eur J Cell Biol  2001  80(5):329-34  PubMed ID: 11432722   DOI: 10.1078/0171-9335-00167
3541  Hidaka K, Kanematsu T, Takeuchi H, Nakata M, Kikkawa U, Hirata M.  Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5.  Int J Biochem Cell Biol  2001  33(11):1094-103  PubMed ID: 11551825   DOI: 10.1016/s1357-2725(01)00067-x
3543  Nakamasu K, Kawamoto T, Yoshida E, Noshiro M, Matsuda Y, Kato Y.  Structure and promoter analysis of the mouse membrane-bound transferrin-like protein (MTf) gene.  Eur J Biochem  2001  268(5):1468-76  PubMed ID: 11231300   DOI: 10.1046/j.1432-1327.2001.02017.x
3998  Thomas DP, Sunters A, Gentry A, Grigoriadis AE.  Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene.  J Cell Sci.  2000  113 ( Pt 3):439-50  PubMed ID: 10639331   DOI: 10.1242/jcs.113.3.439
3550  Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T, Komori T.  Cbfa1 is a positive regulatory factor in chondrocyte maturation.  J Biol Chem  2000  275(12):8695-702  PubMed ID: 10722711   DOI: 10.1074/jbc.275.12.8695
3540  Kusanagi K, Inoue H, Ishidou Y, Mishima HK, Kawabata M, Miyazono K.  Characterization of a bone morphogenetic protein-responsive Smad-binding element.  Mol Biol Cell  2000  11(2):555-65  PubMed ID: 10679014   DOI: 10.1091/mbc.11.2.555
3957  Nakamura K, Shirai T, Morishita S, Uchida S, Saeki-Miura K, Makishima F.  p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells.  Exp Cell Res  1999  250(2):351-63  PubMed ID: 10413589   DOI: 10.1006/excr.1999.4535
3971  Fujishige K, Kotera J, Yanaka N, Akatsuka H, Omori K.  Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5.  Biochim Biophys Acta.   1999  1452(3):219-27  PubMed ID: 10590311   DOI: 10.1016/s0167-4889(99)00141-x
3547  Fujii M, Takeda K, Imamura T, Aoki H, Sampath TK, Enomoto S, Kawabata M, Kato M, Ichijo H, Miyazono K.  Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.  Mol Biol Cell  1999  10(11):3801-13  PubMed ID: 10564272   DOI: 10.1091/mbc.10.11.3801
3548  Ohta S, Muramatsu H, Senda T, Zou K, Iwata H, Muramatsu T.  Midkine is expressed during repair of bone fracture and promotes chondrogenesis.  J Bone Miner Res  1999  14(7):1132-44  PubMed ID: 10404013   DOI: 10.1359/jbmr.1999.14.7.1132
2272  Fujishige K, Yanaka N, Akatsuka H, Omori K  Localization of clearance receptor in rat lung and trachea : association with chondrogenic differentiation  Am J Physiol  1998  274(3 Pt 1):425-431  PubMed ID: 9530179   DOI: 10.1152/ajplung.1998.274.3.L425
3545  Shibata M, Fujino E, Sato Y, Numazawa S, Yoshida T, Kuroiwa Y.  Inhibition of insulin-induced chondrogenic differentiation of embryonic carcinoma cells by a teratogenic compound YM9429.  Biochem Biophys Res Commun  1996  225(2):593-9  PubMed ID: 8753805   DOI: 10.1006/bbrc.1996.1216
10022  Hagerty RC.  Central suspension technique of the midface.  Plast. Reconstr. Surg.  1995  96:728-30  PubMed ID: 7638301   DOI: 10.1097/00006534-199509000-00030



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