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Cell No. : Cell Name
RCB0565 : ATDC5  update : 2020/09/24
CommentDifferentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Atsumi, Tadao
Originator Atsumi, Tadao
Year of deposit 1991
Original cell AT805
Animal mouse < Mammals
Strain name 129
Gender Male
Age at sampling embryo
Tissue embryo
Case history Teratocarcinoma AT805 derived
Classification cancer
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 5% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Reference information Reference 5
User's Publication 391

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1682  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.  Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.  J Cell Sci  2007  120(Pt 5):849-57  PubMed ID: 17298979
1681  Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y.  Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro.  J Bone Miner Res  1997  12(8):1174-88  PubMed ID: 9258747
1687  Shukunami C, Shigeno C, Atsumi T, Ishizeki K, Suzuki F, Hiraki Y.  Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.  J Cell Biol  1996  133(2):457-68  PubMed ID: 8609176
1688  Atsumi T, Miwa Y, Kimata K, Ikawa Y  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Cell Differ Dev  1990  30:109-16  PubMed ID: 2201423
2605  Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S  Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.  Dev Growth Differ  1981  87:340-350  PubMed ID: 6793433

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User's Publication
11853  Li C, Zheng Z, Ha P, Jiang W, Berthiaume EA, Lee S, Mills Z, Pan H, Chen EC, Jiang J, Culiat CT, Zhang X, Ting K, Soo C.  Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug.  Biomaterials  2020    PubMed ID: 31634652
6910  Dong Y, Yan X, Yang X, Yu C, Deng Y, Song X, Zhang L.  Notoginsenoside R1 suppresses miR-301a via NF-κB pathway in lipopolysaccharide-treated ATDC5 cells.  Exp Mol Pathol  2020    PubMed ID: 31837326
6950  Kim JM, Han H, Bahn M, Hur Y, Yeo CY, Kim DW.  Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened.  Biochem J  2020  477(1):121-136  PubMed ID: 31845979
11975  Hirose N, Okamoto Y, Yanoshita M, Asakawa Y, Sumi C, Takano M, Nishiyama S, Su SC, Mitsuyoshi T, Kunimatsu R, Tanne K, Tanimoto K.  Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress.  Cell Biol. Int.  2020    PubMed ID: 31876323
11976  Ukita M, Matsushita K, Tamura M, Yamaguchi T.  Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis.  Int. J. Mol. Med.  2020    PubMed ID: 31894302
11982  Chu J, Yan B, Zhang J, Peng L, Ao X, Zheng Z, Jiang T, Zhang Z.  Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.  Inflammation  2020    PubMed ID: 31897918
12101  Okada K, Mori D, Makii Y, Nakamoto H, Murahashi Y, Yano F, Chang SH, Taniguchi Y, Kobayashi H, Semba H, Takeda N, Piao W, Hanaoka K, Nagano T, Tanaka S, Saito T.  Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.  Sci Rep  2020    PubMed ID: 32214220
12114  Jiang Q, Qin X, Yoshida CA, Komori H, Yamana K, Ohba S, Hojo H, Croix BS, Kawata-Matsuura VKS, Komori T.  Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis.  Int J Mol Sci  2020    PubMed ID: 32244499
12324  Komuro H, Wint WY, Horiuchi N, Nozaki K, Sasano T, Miyashin M, Yamashita K, Nagai A.  An oriented hydroxyapatite film with arrayed plate-like particles enhance chondrogenic differentiation of ATDC5 cells  J Biomed Mater Res A   2020  108(3):537-544  PubMed ID: 31702862
11328  Liu G, Wang Y, Zhang M, Zhang Q.  Long non-coding RNA THRIL promotes LPS-induced inflammatory injury by down-regulating microRNA-125b in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30521964
11356  Shimo T, Koyama E, Okui T, Masui M, Kunisada Y, Ibaragi S, Yoshioka N, Kurio N, Yoshida S, Sasaki A, Iwamoto M.  Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression.  In Vivo  2019    PubMed ID: 30587607
11403  Yamaguchi Y, Kanzaki H, Miyamoto Y, Itohiya K, Fukaya S, Katsumata Y, Nakamura Y.  Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth.  Bone  2019    PubMed ID: 30682567
11417  Steinbusch MMF, Caron MMJ, Surtel DAM, van den Akker GGH, van Dijk PJ, Friedrich F, Zabel B, van Rhijn LW, Peffers MJ, Welting TJM.  The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.  J. Biol. Chem.  2019    PubMed ID: 30718282
11438  Ying H, Wang Y, Gao Z, Zhang Q.  Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30771739
11449  Lin C, Liu L, Zeng C, Cui ZK, Chen Y, Lai P, Wang H, Shao Y, Zhang H, Zhang R, Zhao C, Fang H, Cai D, Bai X.  Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12.  Bone Res  2019    PubMed ID: 30792936
11478  Lian C, Wang X, Qiu X, Wu Z, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.  Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction.  Bone Res  2019    PubMed ID: 30854241
4055  Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T.  Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.  Nat Commun  2019  10:1442  PubMed ID: 30926814
11510  Choi S, Kim HY, Cha PH, Seo SH, Lee C, Choi Y, Shin W, Heo Y, Han G, Lee W, Choi KY.  CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.  Life Sci Alliance  2019    PubMed ID: 30971423
11512  Chu P, Wang Q, Wang Z, Gao C.  Long non-coding RNA highly up-regulated in liver cancer protects tumor necrosis factor-alpha-induced inflammatory injury by down-regulation of microRNA-101 in ATDC5 cells.  Int. Immunopharmacol.  2019    PubMed ID: 30981080
11519  Horita M, Nishida K, Hasei J, Furumatsu T, Sakurai M, Onodera Y, Fukuda K, Salter DM, Ozaki T.  Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions.  Calcif. Tissue Int.  2019    PubMed ID: 30993375
11532  Yu C, Shi D, Li Z, Wan G, Shi X.  Long noncoding RNA CHRF exacerbates IL-6-induced inflammatory damages by downregulating microRNA-146a in ATDC5 cells.  J. Cell. Physiol.  2019    PubMed ID: 31026064
11564  Zhang Q, Wang Y, Zhang M, Ying H.  Green tea polyphenols attenuate LPS-induced inflammation through upregulating microRNA-9 in murine chondrogenic ATDC5 cells.  J. Cell. Physiol.  2019    PubMed ID: 31102286
11588  Liu Q, Li M, Jiang L, Jiang R, Fu B.  METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31186141
11592  Ueda Y, Yasoda A, Hirota K, Yamauchi I, Yamashita T, Kanai Y, Sakane Y, Fujii T, Inagaki N.  Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment.  Sci Rep  2019    PubMed ID: 31189976
11597  Li X, Yu M, Han L, Chen L, Zhang D, Zhou G, Zhao Q, Sun T.  LINC00305 represses miR-124 expression to trigger inflammatory insults in the presence of lipopolysaccharide.  Artif Cells Nanomed Biotechnol  2019    PubMed ID: 31190561
11605  Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.  Loss of autophagy in chondrocytes causes severe growth retardation.  Autophagy  2019    PubMed ID: 31203752
11606  Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X.  MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.  Mol. Cell. Biochem.  2019    PubMed ID: 31227976
11650  Li Y, Mu W, Ren J, Wuermanbieke S, Wahafu T, Ji B, Ma H, Amat A, Zhang K, Cao L.  Artesunate alleviates interleukin‑1β‑induced inflammatory response and apoptosis by inhibiting the NF‑κB signaling pathway in chondrocyte‑like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.  Int. J. Mol. Med.  2019    PubMed ID: 31364719
11680  Al HalifaSoultan, Dennis Lambrechts, Thomas Verheyen, Hans Van Gorp, Maarten B.J. Roeffaers, Mario Smet, Wim M. De Borggraeve, Jennifer Patterson  Nanocarrier systems assembled from PEGylated hyperbranched poly(arylene oxindole)  European Polymer Journal  2019   
11741  Ogawa Y, Takahashi N, Takemoto T, Nishiume T, Suzuki M, Ishiguro N, Kojima T.  Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells.  PLoS ONE  2019    PubMed ID: 31393869
11785  Gunnella F, Kunisch E, Horbert V, Maenz S, Bossert J, Jandt KD, Plöger F, Kinne RW.  In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement.  Pharmaceutics  2019    PubMed ID: 31484306
11789  Mei X, Tong J, Zhu W, Zhu Y.  lncRNA‑NR024118 overexpression reverses LPS‑induced inflammatory injury and apoptosis via NF‑κB/Nrf2 signaling in ATDC5 chondrocytes.  Mol Med Rep  2019    PubMed ID: 31485657
11803  Choi S, Cha PH, Kim HY, Choi KY.  Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway.  Exp. Mol. Med.  2019    PubMed ID: 31515471
11843  Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y.  FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.  J. Biol. Chem.  2019    PubMed ID: 31601652
6878  Yano F, Ohba S, Murahashi Y, Tanaka S, Saito T, Chung UI.  Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation.  Sci Rep  2019  9(1):7666  PubMed ID: 31113964
9791  Carolina Gonçalves-Fernández, Jorge Sineiro, Ramón Moreira & Oreste Gualillo   Extraction and characterization of phlorotannin-enriched fractions from the Atlantic seaweed Bifurcaria bifurcata and evaluation of their cytotoxic activity in murine cell line  Journal of Applied Phycology volume  2019  31:2573–2583 
11915  Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, Mori Y, Makii Y, Oichi T, Taketo MM, Hojo H, Ohba S, Chung UI, Tanaka S, Saito T.  Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.  Arthritis Res. Ther.  2019    PubMed ID: 31771658
10570  Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.  Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.  Osteoarthr. Cartil.  2018  26:108-117  PubMed ID: 29074299
10670  Liang X, Wang X, Xu Q, Lu Y, Zhang Y, Xia H, Lu A, Zhang L.  Rubbery Chitosan/Carrageenan Hydrogels Constructed through an Electroneutrality System and Their Potential Application as Cartilage Scaffolds.  Biomacromolecules  2018  19:340-352  PubMed ID: 29253344
10707  Li C, Zheng Z, Zhang X, Asatrian G, Chen E, Song R, Culiat C, Ting K, Soo C.  Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes.  Int J Mol Sci  2018  19:  PubMed ID: 29316655
10715  Lin C, Shao Y, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D, Xian CJ.  Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis.  J. Cell. Physiol.  2018  233:6135-6147  PubMed ID: 29323710
10732  Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.  SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 29402405
10752  Li F, Sun J, Huang S, Su G, Pi G.  LncRNA GAS5 Overexpression Reverses LPS-Induced Inflammatory Injury and Apoptosis Through Up-Regulating KLF2 Expression in ATDC5 Chondrocytes.  Cell. Physiol. Biochem.  2018  45:1241-1251  PubMed ID: 29448248
10779  Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.  Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.  Development  2018  145:  PubMed ID: 29511023
10791  Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.  Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.  J Transl Med  2018  16:72  PubMed ID: 29554973
10793  Matsumoto N, Kaneko M, Watanabe N, Itaoka M, Seki Y, Morimoto T, Torii T, Miyamoto Y, Keiichi Homma , Yamauchi J.  Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation.  Biochem. Biophys. Res. Commun.  2018  499:78-85  PubMed ID: 29567474
10823  Liang Z, Ren C.  Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells.  Biomed. Pharmacother.  2018  103:897-902  PubMed ID: 29710506
10843  Yanoshita M, Hirose N, Okamoto Y, Sumi C, Takano M, Nishiyama S, Asakawa-Tanne Y, Horie K, Onishi A, Yamauchi Y, Mitsuyoshi T, Kunimatsu R, Tanimoto K.  Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes.  Inflammation  2018  41(5):1621-1630  PubMed ID: 29737477
11046    Semaphorin 3A inhibits inflammation in chondrocytes under excessive mechanical stress  Mediators of Inflammation  2018  2018, 9  PubMed ID: 29849491
11154  Wang Y, Kong D.  MicroRNA-136 promotes lipopolysaccharide-induced ATDC5 cell injury and inflammatory cytokine expression by targeting myeloid cell leukemia 1.  J. Cell. Biochem.  2018  119(11):9316-9326  PubMed ID: 30074264
11185  Pan L, Liu D, Zhao L, Wang L, Xin M, Li X.  Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells.  J. Cell. Biochem.  2018  119(12):10165-10175  PubMed ID: 30145831
11286  Dong R, Ying J, Xu T, Hu S, Zhang P, Xia C, Fang L, Jin H, Wang P.  Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway.  Evid Based Complement Alternat Med  2018    PubMed ID: 30402118
11264  Kudva AK, Luyten FP, Patterson J.  In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells.  Int J Mol Sci  2018    PubMed ID: 30373138
11274  Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM.  SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30389141
11305  Pirozzi C, Francisco V, Guida FD, Gómez R, Lago F, Pino J, Meli R, Gualillo O.  Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor.  Cell. Physiol. Biochem.  2018    PubMed ID: 30448827
4144  Xu W, Wang Y, Zhao H, Fan B, Guo K, Cai M, Zhang S.  Delta-like 2 negatively regulates chondrogenic differentiation.  J. Cell. Physiol.  2018    PubMed ID: 29057471
4145  Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.  Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.  PLoS ONE  2018    PubMed ID: 30281599
4146  Nasrabadi D, Rezaeiani S, Sayadmanesh A, Baghaban Eslaminejad M, Shabani A.  Inclusion Body Expression and Refolding of Recombinant Bone Morphogenetic Protein-2.  Avicenna J Med Biotechnol  2018    PubMed ID: 30555651
4147  Luan L, Liang Z.  Tanshinone IIA protects murine chondrogenic ATDC5 cells from lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-203a.  Biomed. Pharmacother.  2018    PubMed ID: 29679904
6644  Yamaguchi K, Asakura K, Imamura M, Kawai G, Sakamoto T, Furihata T, Linhardt RJ, Igarashi K, Toida T, Higashi K.  Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region.  Biochem J  2018  475(23):3797-3812  PubMed ID: 30401686
6643  Wang C, Tan Z, Niu B, Tsang KY, Tai A, Chan WCW, Lo RLK, Leung KKH, Dung NWF, Itoh N, Zhang MQ, Chan D, Cheah KSE.  Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia.  Elife  2018  7. pii: e37673  PubMed ID: 30024379
9829  Jiang M, Fu X, Yang H, Long F, Chen J.  mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.  J. Cell. Biochem.  2017  118:748-753  PubMed ID: 27606668
9905  Taniguchi Y, Kawata M, Ho Chang S, Mori D, Okada K, Kobayashi H, Sugita S, Hosaka Y, Inui H, Taketomi S, Yano F, Ikeda T, Akiyama H, Mills AA, Chung UI, Tanaka S, Kawaguchi H, Saito T.  Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.  Arthritis Rheumatol  2017  69:598-609  PubMed ID: 27792866
10062  Funato S, Yasuhara R, Yoshimura K, Miyamoto Y, Kaneko K, Suzawa T, Chikazu D, Mishima K, Baba K, Kamijo R.  Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner.  Cell Tissue Res.  2017  368:135-144  PubMed ID: 28070636
10105  Le BQ, Vasilevich A, Vermeulen S, Hulshof F, Stamatialis DF, van Blitterswijk CA, de Boer J.  Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line.  Tissue Eng Part A  2017  23:458-469  PubMed ID: 28152670
10119  Conde J, Lazzaro V, Scotece M, Abella V, Villar R, López V, Gonzalez-Gay MÁ, Pino J, Gómez R, Mera A, Gualillo O.  Corticoids synergize with IL-1 in the induction of LCN2.  Osteoarthr. Cartil.  2017  25:1172-1178  PubMed ID: 28185846
10131  Wang CL, Wang H, Xiao F, Wang CD, Hu GL, Zhu JF, Shen C, Zuo B, Cui YM, Li , Yuan-Gao , Zhang XL, Chen XD.  Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.  Biochem. Biophys. Res. Commun.  2017  485:400-408  PubMed ID: 28213129
10273  Quang Le B, Van Blitterswijk C, De Boer J.  An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair.  Bioengineering (Basel)  2017  4:  PubMed ID: 28952514
10295  Im S, Kim DW.  Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.  Cell. Signal.  2017  36:127-138  PubMed ID: 28479297
10306  Cao L, Zhang F, Wang Q, Wu X.  Fabrication of chitosan/graphene oxide polymer nanofiber and its biocompatibility for cartilage tissue engineering.  Mater Sci Eng C Mater Biol Appl  2017  79:697-701  PubMed ID: 28629070
10434  Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, Zhang L, Mi M, Chen D, Tong P, Jin H.  Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.  Int. J. Biol. Sci.  2017  13:996-1007  PubMed ID: 28924381
10505  Yuan Y, Tan H, Dai P.  Krüppel-Like Factor 2 Regulates Degradation of Type II Collagen by Suppressing the Expression of Matrix Metalloproteinase (MMP)-13.  Cell. Physiol. Biochem.  2017  42:2159-2168  PubMed ID: 28873368
10534  Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A, Cao L.  Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.  Mol Med Rep  2017  16:7679-7684  PubMed ID: 28944864
10547  Ji B, Guo W, Ma H, Xu B, Mu W, Zhang Z, Amat A, Cao L.  Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.  Int. J. Mol. Med.  2017  40:1709-1718  PubMed ID: 29039445
10631  Kudo T, Nakatani S, Kakizaki M, Arai A, Ishida K, Wada M, Kobata K.  Supplemented Chondroitin Sulfate and Hyaluronic Acid Suppress Mineralization of the Chondrogenic Cell Line, ATDC5, via Direct Inhibition of Alkaline Phosphatase.  Biol. Pharm. Bull.  2017  40:2075-2080  PubMed ID: 29199232
10636  Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T.  Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells.  Sci Rep  2017  7:16701  PubMed ID: 29196633
10651  Taipale M, Solovieva S, Leino-Arjas P, Männikkö M.  Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.  BMC Genet.  2017  18:108  PubMed ID: 29233086
10918    Effects of a Chemically Synthesized Leucine-Rich Amelogenin Peptide (csLRAP) on Chondrogenic and Osteogenic Cells  Journal of Hard Tissue Biology  2017  26, 51- 60 
10986  Yano K, Washio K, Tsumanuma Y, Yamato M, Ohta K, Okano T, Izumi Y.  The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth  Regen Ther  2017  7:98-107  PubMed ID: 30271858
6635  Seher A, Lagler C, Stühmer T, Müller-Richter UDA, Kübler AC, Sebald W, Müller TD, Nickel J.  Utilizing BMP-2 muteins for treatment of multiple myeloma.  PLoS One  2017  12(5):e0174884  PubMed ID: 28489849
6636  Meng X, Cui J, Wang Y, Zhang X, Li D, Hai Y, Du H.  Heterogeneous nuclear ribonucleoprotein A1 interacts with microRNA-34a to promote chondrogenic differentiation of mesenchymal stem cells.  Am J Transl Res  2017  9(4):1774-1782  PubMed ID: 28469782
6637  Shangguan L, Ning G, Luo Z, Zhou Y  Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/β-catenin signaling.  Int J Biol Macromol  2017  99:293-299  PubMed ID: 28238906
6638  Otsuki S, Murakami T, Okamoto Y, Hoshiyama Y, Oda S, Neo M.  Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.  Histol Histopathol  2017  32(7):725-733  PubMed ID: 27808352
6639  Ota T, Nishida Y, Ikuta K, Kato R, Kozawa E, Hamada S, Sakai T, Ishiguro N.  Heat-stimuli-enhanced osteogenesis using clinically available biomaterials.  PLoS One  2017  12(7):e0181404  PubMed ID: 28719650
7079  Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T, Alswaid A, Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A, Rustad CF, Merckoll E, Westvik J, Stattin EL, Grigelioniene G, Kou I, Nakajima M, Ohashi H, Smithson S, Matsumoto N, Nishimura G, Ikegawa S.  Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.  PLoS ONE  2016  11:e0150555  PubMed ID: 26974433
7085  Hosokawa T, Tsuchiya Y, Okubo N, Kunimoto T, Minami Y, Fujiwara H, Umemura Y, Koike N, Kubo T, Yagita K.  Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells.  Acta Histochem Cytochem  2016  48:165-71  PubMed ID: 26855448
7086  Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K.  Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.  Biochem. Biophys. Res. Commun.  2016  470:356-361  PubMed ID: 26777999
7124  Staines KA, Prideaux M, Allen S, Buttle DJ, Pitsillides AA, Farquharson C.  E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.  J. Cell. Physiol.  2016  231:1392-404  PubMed ID: 26639105
7185  Zaman G, Staines KA, Farquharson C, Newton PT, Dudhia J, Chenu C, Pitsillides AA, Dhoot GK.  Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.  Histochem. Cell Biol.  2016  145:67-79  PubMed ID: 26464246
9530  Meng F, Zhang Z, Chen W, Huang G, He A, Hou C, Long Y, Yang Z, Zhang Z, Liao W.  MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses.  Osteoarthr. Cartil.  2016  24:932-41  PubMed ID: 26774733
9538  Niu Q, Li F, Zhang L, Xu X, Liu Y, Gao J, Feng X.  Role of the Wnt/β-catenin signaling pathway in the response of chondrocytes to mechanical loading.  Int. J. Mol. Med.  2016  37:755-62  PubMed ID: 26821383
9563  Abella V, Scotece M, Conde J, López V, Pirozzi C, Pino J, Gómez R, Lago F, González-Gay MÁ, Gualillo O.  The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.  Sci Rep  2016  6:20356  PubMed ID: 26853108
9567  Saito M, Mulati M, Talib SZ, Kaldis P, Takeda S, Okawa A, Inose H.  The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development.  Sci Rep  2016  6:20622  PubMed ID: 26860366
9645  Caron MM, Emans PJ, Sanen K, Surtel DA, Cremers A, Ophelders D, van Rhijn LW, Welting TJ.  The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells.  PLoS ONE  2016  11:e0153162  PubMed ID: 27050768
9648  Pathak JL, Verschueren P, Lems WF, Bravenboer N, Klein-Nulend J, Bakker AD, Luyten FP.  Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells.  Connect. Tissue Res.  2016  57:226-35  PubMed ID: 27050327
9704  Conde J, Otero M, Scotece M, Abella V, López V, Pino J, Gómez R, Lago F, Goldring MB, Gualillo O.  E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes.  J. Physiol. (Lond.)  2016  594:6133-6146  PubMed ID: 27222093
9705  Kim H, Park H, Lee JW, Lee KY.  Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.  Carbohydr Polym  2016  151:467-473  PubMed ID: 27474590
9721  Choi HJ, Kwon S, Kim DW.  A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.  Cell. Signal.  2016  28:1336-48  PubMed ID: 27312341
9746  Nakajima M, Kou I, Ohashi H, , Ikegawa S.  Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.  Am. J. Hum. Genet.  2016  99:202-7  PubMed ID: 27374772
9754  Higa K, Kitamura N, Kurokawa T, Goto K, Wada S, Nonoyama T, Kanaya F, Sugahara K, Gong JP, Yasuda K.  Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method.  Acta Biomater  2016  43:38-49  PubMed ID: 27427226
9768  Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H.  Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.  PLoS ONE  2016  11:e0159375  PubMed ID: 27467521
9812  Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Sci Rep  2016  6:31986  PubMed ID: 27558955
9831  Chen W, Chen L, Zhang Z, Meng F, Huang G, Sheng P, Zhang Z, Liao W.  MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.  Biochim. Biophys. Acta  2016  1863:2881-2891  PubMed ID: 27638301
9852  Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T.  Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.  Sci Rep  2016  6:33549  PubMed ID: 27650265
9927  Kobayashi H, Chang SH, Mori D, Itoh S, Hirata M, Hosaka Y, Taniguchi Y, Okada K, Mori Y, Yano F, Chung UI, Akiyama H, Kawaguchi H, Tanaka S, Saito T.  Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.  Nat Commun  2016  7:13336  PubMed ID: 27830706
9987  Chen Z, Jin T, Lu Y.  AntimiR-30b Inhibits TNF-α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy.  Cell. Physiol. Biochem.  2016  40:883-894  PubMed ID: 27941314
10870    High throughput screening for modulators of ACVR1 transcription potentially applicable to the treatment of Fibrodysplasia Ossificans Progressiva  Disease Models & Mechanisms  2016  9, 1067 
4790  Zhang Y, Dong R2, Park Y1, Bohner M3, Zhang X4, Ting K5, Soo C5, Wu BM6.  Controlled release of NELL-1 protein from chitosan/hydroxyapatite-modified TCP particles.  Int J Pharm  2016  511(1):79-89  PubMed ID: 27349789
6622  Laurie LE, Kokubo H, Nakamura M, Saga Y, Funato N.  The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.  PLoS One  2016  11(2):e0150263  PubMed ID: 26918743
6623  Yang M, Li L, Heo SM, Soh Y.  Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways.  Biomol Ther (Seoul)  2016  24(4):395-401  PubMed ID: 27350340
6624  Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K.  R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.  Biochem Biophys Res Commun  2016  473(1):255-264  PubMed ID: 27012200
6625  Cao Z, Dou C, Li J, Tang X, Xiang J, Zhao C2, Zhu L, Bai Y, Xiang Q, Dong S.  Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway.  BMB Rep  2016  49(10):548-553  PubMed ID: 27439604
6630  Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X.  mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.  Nat Commun  2016  7:11151  PubMed ID: 27039827
6631  Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ.  HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.  J Cell Sci  2016  129(11):2145-55  PubMed ID: 27160681
6632  Jasmin L. Whittaker, Naba K. Dutta, Andrew Zannettino and Namita Roy Choudhury  Engineering DN hydrogels from regenerated silk fibroin and poly(N-vinylcaprolactam)  J Mater Chem B  2016  4:5519-5533 
6633  Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta LJ, Sormani M, Giovenzana A, Spinelli AE, Canciani B, Brunelli S, Ravazzolo R, Bocciardi R.  Correction: High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva.  Dis Model Mech  2016  Sep 1;9(9):1067  PubMed ID: 27604694
7151  Goto K, Kimura T, Kitamura N, Semba S, Ohmiya Y, Aburatani S, Matsukura S, Tsuda M, Kurokawa T, Ping Gong J, Tanaka S, Yasuda K.  Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.  J Biomed Mater Res A  2015  104:734-746  PubMed ID: 26566602
7192  Naito M, Vongsa S, Tsukune N, Ohashi A, Takahashi T.  Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5.  Mol. Cell. Endocrinol.  2015  417:114-23  PubMed ID: 26419928
7217  Kim JA, Im S, Cantley LC, Kim DW.  Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.  Cell. Signal.  2015  27:2389-400  PubMed ID: 26363466
7248  Mori H, Izawa T, Tanaka E.  Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.  Am. J. Pathol.  2015  185:2742-56  PubMed ID: 26272361
7279  Hou C, Meng F, Zhang Z, Kang Y, Chen W, Huang G, Fu M, Sheng P, Zhang Z, Liao W.  The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.  Cell. Physiol. Biochem.  2015  36:1753-66  PubMed ID: 26184031
7291  Hou C, Zhang Z, Zhang Z, Wu P, Zhao X, Fu M, Sheng P, Kang Y, Liao W.  Presence and function of microRNA-92a in chondrogenic ATDC5 and adipose-derived mesenchymal stem cells.  Mol Med Rep  2015  12:4877-86  PubMed ID: 26135269
7329  Santoro A, Conde J, Scotece M, Abella V, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O.  Choosing the right chondrocyte cell line: Focus on nitric oxide.  J. Orthop. Res.  2015  33:1784-8  PubMed ID: 26016689
7367  Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.  Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.  Histochem. Cell Biol.  2015  144:167-77  PubMed ID: 25929745
7433  Umeda M, Terao F, Miyazaki K, Yoshizaki K, Takahashi I.  MicroRNA-200a Regulates the Development of Mandibular Condylar Cartilage.  J. Dent. Res.  2015  94:795-802  PubMed ID: 25784252
7450  Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S.  Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.  PLoS ONE  2015  10:e0119177  PubMed ID: 25749104
7487  Abella V, Santoro A, Scotece M, Conde J, Lopez-Lopez V, Lazzaro V, Gomez-Reino JJ, Meli R, Gualillo O.  Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways.  Toxicol. Lett.  2015  234:13-9  PubMed ID: 25659934
7506  Le BQ, Fernandes H, Bouten CV, Karperien M, van Blitterswijk C, de Boer J.  High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.  Tissue Eng Part C Methods  2015  21:726-36  PubMed ID: 25604243
3917  Hutchison MR, White PC.  Prostacyclin regulates bone growth via the Epac/Rap1 pathway.  Endocrinology  2015  156(2):499-510  PubMed ID: 25406016
6612  Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung UI, Tanaka S, Saito T.  Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding proteins.  Biomed Res  2015  36(1):21-9  PubMed ID: 25749148
6613  Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.  GDF-5 can act as a context-dependent BMP-2 antagonist.  BMC Biol  2015  13:77  PubMed ID: 26385096
6614  Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W.  MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.  FEBS Lett  2015  589(23):3671-8  PubMed ID: 26474644
6615  Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.  A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.  Sci Signal  2015  8(386):ra71  PubMed ID: 26198357
6616  Nonni Soraya et al  Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineeringcccc  Composites Science and Technology   2015  106:76-84 
6617  Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston TN.  Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension.  Elife  2015  4:e09300  PubMed ID: 26652004
6620  Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T.  AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.  Bone  2015  74:125-33  PubMed ID: 25497570
6469  Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.  6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.  Mol Nutr Food Res  2014  58(2):256-66  PubMed ID: 24039109
3517  Kosaka T, Fukui R, Matsui M, Kurosaka Y, Nishimura H, Tanabe M, Takakura Y, Iwai K, Waki T, Fujita T.  RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.  PLoS One  2014  9(9):e108819  PubMed ID: 25275461
6579  Kawamura D, Funakoshi T, Mizumoto S, Sugahara K, Iwasaki N.  Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.  J Orthop Sci  2014  19(6):1028-35  PubMed ID: 25209441
6580  Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K.  Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells.  BMC Musculoskelet Disord  2014  15:222  PubMed ID: 24997593
6581  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.  High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.  J Orthop Res  2014  32(12):1619-27  PubMed ID: 25196420
6582  Yuji Hatakeyama, Yuko Matsuda, Junko Hatakeyama, Kyoko Oka, Hisashi Anan, Eichi Tsuruga, Tetsuichiro Inai, Hiroyuki Ishikawa, Yoshihiko Sawa  The effect of growth differentiation factor-5, 6, 7 in chondrogenic cell differentiation of ATDC-5   American Journal of BioScience  2014  2(5):182-186  
6583  Nakajima M et al  A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.  Nat Genet  2014  46(9):1012-6  PubMed ID: 25064007
6584  Suzuki N, Mizuniwa C, Ishii K, Nakagawa Y, Tsuji K, Muneta T, Sekiya I, Akazawa C.  Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.  J Orthop Res  2014  32(7):915-22  PubMed ID: 24648313
6585  Eijiro Maeda et al  Significant increase in Young׳s modulus of ATDC5 cells during chondrogenic differentiation induced by PAMPS/PDMAAm double-network gel: Comparison with induction by insulin  Journal of Biomechanics  2014  47:3408-3414  PubMed ID: 25110167
6586  Maenz S, Kunisch E, Mühlstädt M, Böhm A, Kopsch V, Bossert J, Kinne RW, Jandt KD.  Enhanced mechanical properties of a novel, injectable, fiber-reinforced brushite cement.  J Mech Behav Biomed Mater  2014  39:328-38  PubMed ID: 25171749
6587  Scotece M, Conde J, Abella V, López V, Lago F, Pino J, Gómez-Reino JJ, Gualillo O.  NUCB2/nesfatin-1: a new adipokine expressed in human and murine chondrocytes with pro-inflammatory properties, an in vitro study.  J Orthop Res  2014  32(5):653-60  PubMed ID: 24464950
6588  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.  Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.  In Vitro Cell Dev Biol Anim  2014  50(4):358-66  PubMed ID: 24092017
6589  Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.  LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.  Biochem Biophys Res Commun  2014  451(2):302-7  PubMed ID: 25091481
6590  Gómez R, Conde J, Scotece M, López V, Lago F, Gómez Reino JJ, Gualillo O.  Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes.  J Orthop Res  2014  32(9):1137-46  PubMed ID: 24902823
6591  Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.  S100A1 and S100B are dispensable for endochondral ossification during skeletal development.  Biomed Res  2014  35(4):243-50  PubMed ID: 25152033
6592  Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.  Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.  PLoS One  2014  9(3):e91421  PubMed ID: 24618907
6593  Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K  Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.  J Biol Chem  2014  289(20):13810-20  PubMed ID: 24711445
6594  Staines KA, Zhu D, Farquharson C, MacRae VE.  Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.  J Bone Miner Metab  2014  32(3):240-51  PubMed ID: 23925391
6595  Bergmann CJ1, Odekerken JC2, Welting TJ2, Jungwirth F, Devine D3, Bouré L3, Zeiter S3, van Rhijn LW2, Telle R4, Fischer H1, Emans PJ2.  Calcium phosphate based three-dimensional cold plotted bone scaffolds for critical size bone defects.  Biomed Res Int  2014  2014:852610  PubMed ID: 24719891
6596  Ushijima T, Okazaki K, Tsushima H, Ishihara K, Doi T, Iwamoto Y.  CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.  PLoS One  2014  9(8):e104547  PubMed ID: 25105964
6597  Woo E, Park H, Lee KY.  Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.  Macromol Biosci  2014  14(5):740-8  PubMed ID: 24436180
6598  Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT.  Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.  PLoS One  2014  9(3):e92194  PubMed ID: 24637783
6599  Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.  Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.  PLoS One  2014  9(3):e92699  PubMed ID: 24658359
6600  Hatta T, Kishimoto KN, Okuno H, Itoi E.  Oxygen tension affects lubricin expression in chondrocytes.  Tissue Eng Part A  2014  20(19-20):2720-7  PubMed ID: 24712343
6602  Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura S.  Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.  Biochim Biophys Acta  2014  1840(1):645-55  PubMed ID: 24161698
6603  Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme NJ, Haines P, Chen Q.  Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells.  Int J Mol Sci  2014  15(8):14555-73  PubMed ID: 25196597
6604  Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.  J Biol Chem  2014  89(14):9865-79  PubMed ID: 24563464
6605  Inagaki Y, Kitamura N, Kurokawa T, Tanaka Y, Gong JP, Yasuda K, Tohyama H.  Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study.  BMC Musculoskelet Disord  2014  15:320  PubMed ID: 25262146
6606  Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.  J Biol Chem  2014  289(12):8135-50  PubMed ID: 24505141
6607  Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.  Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.  Neurochem Int  2014  74:24-35  PubMed ID: 24768841
6430  Kwon HJ, Ohmiya Y.  Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.  Biomed Res Int  2013  2013:213972  PubMed ID: 23878799
6464  Gómez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O.  Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes.  J Orthop Res  2013  31(7):1046-52  PubMed ID: 23483583
6465  Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.  Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.  J Biol Chem  2013  288(40):28620-9  PubMed ID: 23963448
6556  Nepal M, Li L, Cho HK, Park JK, Soh Y.  Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway.  Food Chem Toxicol  2013  62:238-45  PubMed ID: 23989061
6557  Miyatake K, Tsuji K, Yamaga M, Yamada J, Matsukura Y, Abula K, Sekiya I, Muneta T.  Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells.  Biochem Biophys Res Commun  2013  431(1):52-7  PubMed ID: 23291184
6558  Hu-Hui Lee, Jing-Yu Lee & Lan-Hsin   Proper Fhl1 expression as Wnt signaling is required for chondrogenesis of ATDC5 cells  Animal Cells and Systems  2013  17:413-420 
6559  Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R.  Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.  Cell Tissue Res  2013  352(2):401-12  PubMed ID: 23274552
6560  Mitani K1 Haruyama N, Hatakeyama J, Igarashi K.  Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells.  Oral Dis  2013  19(2):169-79  PubMed ID: 22863294
6561  Morimoto H, Baba R, Haneji T, Doi Y.  Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5.  Cell Tissue Res  2013  351(1):41-7  PubMed ID: 23180319
6562  Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.  Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.  J Pharmacol Sci  2013  122(4):318-25  PubMed ID: 23883486
6563  Yoshikawa K, Kitamura N, Kurokawa T, Gong JP, Nohara Y, Yasuda K.  Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.  BMC Musculoskelet Disord  2013  14:56  PubMed ID: 23379610
6564  Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.  Proc Natl Acad Sci U S A  2013  110(5):1875-80  PubMed ID: 23319657
6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878
6566  Kwon HJ.  ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.  Cell Biochem Funct  2013  31(1):75-81  PubMed ID: 22886426
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6570  Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M.  Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.  FEBS Open Bio  2013  3:279-84  PubMed ID: 23905010
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6573  Uyama T, Inoue M, Okamoto Y, Shinohara N, Tai T, Tsuboi K, Inoue T, Tokumura A, Ueda N.  Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation.  Biochim Biophys Acta  2013  1831(12):1690-701  PubMed ID: 23994608
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6576  Giacopelli F, Cappato S, Tonachini L, Mura M, Di Lascio S, Fornasari D, Ravazzolo R, Bocciardi R.  Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva.  Orphanet J Rare Dis  2013  8:145  PubMed ID: 24047559
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4965  Seriwatanachai D, Krishnamra N, Charoenphandhu N.  Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures.  Biochem Biophys Res Commun  2012  420(1):108-13  PubMed ID: 22405773
5029  Kambe Y, Hayashi N, Tomita N.  Adhesive force behavior of single ATDC5 cells in chondrogenic culture.  Biochem Biophys Res Commun  2012  420(2):241-6  PubMed ID: 22425987
5270  Li L, Eun JS, Nepal M, Ryu JH, Cho HK, Choi BY, Soh Y.  Isopsoralen Induces Differentiation of Prechondrogenic ATDC5 Cells via Activation of MAP Kinases and BMP-2 Signaling Pathways.  Biomol Ther (Seoul)  2012  20(3):299-305  PubMed ID: 24130927
5310  Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta  Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.  Nanomedicine (Lond).  2012  7(7):981-93  PubMed ID: 22401267
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5341  Weiss HE, Roberts SJ, Schrooten J, Luyten FP.  A semi-autonomous model of endochondral ossification for developmental tissue engineering.  Tissue Eng Part A  2012  18(13-14):1334-43  PubMed ID: 22394057
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6233  Chen CG, Thuillier D, Chin EN, Alliston T.  Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.  Arthritis Rheum  2012  64(10):3278-89  PubMed ID: 22674505
6415  Hou Y, Hu J, Park H, Lee M.  Chitosan-based nanoparticles as a sustained protein release carrier for tissue engineering applications.  J Biomed Mater Res A  2012  100(4):939-47  PubMed ID: 22275184
6416  Pass C, MacRae VE, Huesa C, Faisal Ahmed S, Farquharson C.  SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.  J Bone Miner Res  2012  27(5):1055-66  PubMed ID: 22228213
6420  Hu J, Hou Y, Park H, Lee M.  Beta-tricalcium phosphate particles as a controlled release carrier of osteogenic proteins for bone tissue engineering.  J Biomed Mater Res A  2012  100(7):1680-6  PubMed ID: 22447727
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6472  Mitsugi S, Ariyoshi W, Okinaga T, Kaneuji T, Kataoka Y, Takahashi T, Nishihara T.  Mechanisms involved in inhibition of chondrogenesis by activin-A.  Biochem Biophys Res Commun  2012  420(2):380-4  PubMed ID: 22425773
6473  Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P.  New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.  J Bone Miner Res  2012  27(2):429-42  PubMed ID: 21976273
6540  Staines KA, Mackenzie NC, Clarkin CE, Zelenchuk L, Rowe PS, MacRae VE, Farquharson C.  MEPE is a novel regulator of growth plate cartilage mineralization.  Bone  2012  51(3):418-30  PubMed ID: 22766095
6541  Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.  Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.  Biochem J  2012  443(3):789-98  PubMed ID: 22507129
6542  Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y.  Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.  J Biol Chem  2012  287(40):33293-303  PubMed ID: 22879594
6543  Kawamura I, Maeda S, Imamura K, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.  J Biol Chem  2012  287(34):29101-13  PubMed ID: 22767605
6544  Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, Yoneda Y.  Clock genes influence gene expression in growth plate and endochondral ossification in mice.  J Biol Chem  2012  287(43):36081-95  PubMed ID: 22936800
6545  Kwon HJ.  TGF-β but not BMP signaling induces prechondrogenic condensation through ATP oscillations during chondrogenesis.  Biochem Biophys Res Commun  2012  424(4):793-800  PubMed ID: 22814106
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6550  Hutchison MR.  BDNF alters ERK/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes.  Mol Endocrinol  2012  26(8):1406-16  PubMed ID: 22700586
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7711  Mirza R, Qiao S, Tateyama K, Miyamoto T, Xiuli L, Seo H.  3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.  J. Bone Miner. Metab.  2011  30:144-53  PubMed ID: 21845517
7760  Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Saamanen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.  Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.  J. Biol. Chem.  2011  286:32140-9  PubMed ID: 21724852
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7805  Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C.  Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.  J. Bone Miner. Res.  2011  26:1230-41  PubMed ID: 21611965
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7887  Yang CL, Chen HW, Wang TC, Wang YJ.  A novel fibrin gel derived from hyaluronic acid-grafted fibrinogen.  Biomed Mater  2011  6:025009  PubMed ID: 21393811
7902  Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.  Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.  J. Biol. Chem.  2011  286:14744-52  PubMed ID: 21372137
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8241  Temu TM, Wu KY, Gruppuso PA, Phornphutkul C.  The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.  Am. J. Physiol. Endocrinol. Metab.  2010  299:E325-34  PubMed ID: 20530736
8308  Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.  Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.  J. Bone Miner. Metab.  2010  28:627-33  PubMed ID: 20376510
8343  Iacono A, Gomez R, Sperry J, Conde J, Bianco G, Meli R, Gomez-Reino JJ, Smith AB 3rd, Gualillo O.  Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line.  Arthritis Rheum.  2010  62:1675-82  PubMed ID: 20201078
8347  Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.  Arthritis Rheum.  2010  62:826-36  PubMed ID: 20187155
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4605  Kwon HJ, Yasuda K, Ohmiya Y, Honma K, Chen YM, Gong JP.  In vitro differentiation of chondrogenic ATDC5 cells is enhanced by culturing on synthetic hydrogels with various charge densities.  Acta Biomater  2010  6(2):494-501  PubMed ID: 19651251
4608  Takayama Y, Mizumachi K.  Inhibitory effect of lactoferrin on hypertrophic differentiation of ATDC5 mouse chondroprogenitor cells.  Biometals  2010  23(3):477-84  PubMed ID: 20094900
4655  Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.  Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.  Int J Mol Med  2010  25(4):593-600  PubMed ID: 20198308
4665  Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.  Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.  Nat Med  2010  16(6):678-86  PubMed ID: 20495570
4669  Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A.  The cleavage of N-cadherin is essential for chondrocyte differentiation.  Biochem Biophys Res Commun  2010  400(4):493-9  PubMed ID: 20735983
4678  Hutchison MR1, Bassett MH, White PC.  SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation.  Mol Endocrinol  2010  24(1):193-203  PubMed ID: 19897599
4679  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257
8425  Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A.  Fibulin-3 negatively regulates chondrocyte differentiation.  Biochem. Biophys. Res. Commun.  2009  391:1116-21  PubMed ID: 20005202
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8608  Gevers EF, Hannah MJ, Waters MJ, Robinson IC.  Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.  Endocrinology  2009  150:3627-36  PubMed ID: 19359380
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6520  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C.  Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.  Am J Physiol Endocrinol Metab  2009  296(6):E1374-82  PubMed ID: 19401455
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6533  Arthritis Rheum  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917
6534  Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A.  Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.  J Cell Biochem  2009  106(4):580-8  PubMed ID: 19142862
6535  Heinecke K, Seher A, Schmitz W, Mueller TD, Sebald W, Nickel J.  Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.  BMC Biol  2009  7:59  PubMed ID: 19735544
6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746
6537  Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K. Author information  Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.  Nat Cell Biol  2009  11(10):1197-204  PubMed ID: 19767744
6538  Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T.  Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.  Mol Biol Cell  2009  20(21):4541-51  PubMed ID: 19759178
6539  Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C.  Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.  J Cell Physiol  2009  218(2):276-84  PubMed ID: 18803233
8706  Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y.  A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect.  Macromol Biosci  2008  9:307-16  PubMed ID: 19031389
6510  Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y.  Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.  Genes Cells  2008  13(4):355-63  PubMed ID: 18363966
6511  Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.  A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.  J Mol Biol  2008  381(4):1025-39  PubMed ID: 18621057
6512  Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O.  Development of a cell culture system loading cyclic mechanical strain to chondrogenic cells.  J Biotechnol  2008  133(2):231-8  PubMed ID: 17904677
6513  Galal N, El Beialy W, Deyama Y, Yoshimura Y, Yoshikawa T, Suzuki K, Totsuka Y.  Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements.  Int J Mol Med  2008  21(6):785-90  PubMed ID: 18506373
6514  Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.  Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.  J Biol Chem  2008  283(39):26499-508  PubMed ID: 18632667
6515  Tanne Y, Tanimoto K, Tanaka N, Ueki M, Lin YY, Ohkuma S, Kamiya T, Tanaka E, Tanne K.  Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation.  Arch Oral Biol  2008  53(5):478-87  PubMed ID: 18242579
6516  Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T.  Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.  Osteoarthritis Cartilage  2008  16(6):723-32  PubMed ID: 18226559
6517  Takarada T, Hinoi E, Takahata Y, Yoneda Y.  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.  J Cell Physiol  2008  215(2):320-8  PubMed ID: 17929246
6518  Roberts SJ, Owen HC, Farquharson C.  Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.  Biochem Biophys Res Commun  2008  371(4):872-6  PubMed ID: 18471996
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406
6521  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.  Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.  J Biol Chem  2008  283(36):24682-9  PubMed ID: 18617520
6522  Schugar RC, Robbins PD, Deasy BM.  Small molecules in stem cell self-renewal and differentiation.  Gene Ther  2008  15(2):126-35  PubMed ID: 17989703
6523  Tiğli RS, Gümüşderelioğlu M.  Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity.  Int J Biol Macromol  2008  43(2):121-8  PubMed ID: 18485469
6524  Owen HC, Roberts SJ, Ahmed SF, Farquharson C.  Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.  Am J Physiol Endocrinol Metab  2008  294(6):E1023-34  PubMed ID: 18381927
8784  Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  FEBS J.  2007  275:172-83  PubMed ID: 18070108
3584  Muramatsu S, Wakabayashi M, Ohno T, Amano K, Ooishi R, Sugahara T, Shiojiri S, Tashiro K, Suzuki Y, Nishimura R, Kuhara S, Sugano S, Yoneda T, Matsuda A.  Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.  J Biol Chem  2007  282(44):32158-67  PubMed ID: 17804410
6167  Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH.  Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.  Dev Dyn  2007  236(5):1313-8  PubMed ID: 17436279
6494  Nakatani S, Mano H, Im R, Shimizu J, Wada M.  Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5.  Biol Pharm Bull  2007  30(3):433-8  PubMed ID: 17329833
6495  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.  The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.  Biomaterials  2007  28(3):434-40  PubMed ID: 16978693
6496  Narukawa M, Suzuki N, Takayama T, Shoji T, Otsuka K, Ito K.  Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells.  J Periodontal Res  2007  42(2):131-7  PubMed ID: 17305871
6497  Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.  Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.  Biochim Biophys Acta  2007  1774(9):1108-17  PubMed ID: 17669701
6498  Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S.  Mechanisms for asporin function and regulation in articular cartilage.  J Biol Chem  2007  282(44):32185-92  PubMed ID: 17827158
6499  Macrae VE, Ahmed SF, Mushtaq T, Farquharson C.  IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.  Growth Horm IGF Res  2007  17(5):435-9  PubMed ID: 17590365
6500  Hinoi E, Takarada T, Fujimori S, Wang L, Iemata M, Uno K, Yoneda Y.  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.  Bone  2007  40(2):337-44  PubMed ID: 17029980
6501  Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.  Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.  Dev Biol  2007  312(2):572-81  PubMed ID: 17997399
6502  Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.  Novel function of TWEAK in inducing intervertebral disc degeneration.  J Orthop Res  2007  25(11):1438-46  PubMed ID: 17568422
6503  Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA.  Regulation of the human SOX9 promoter by Sp1 and CREB.  Exp Cell Res  2007  313(6):1069-79  PubMed ID: 17289023
6504  Owen HC, Miner JN, Ahmed SF, Farquharson C.  The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.  Mol Cell Endocrinol  2007  264(1-2):164-70  PubMed ID: 17182172
6505  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Identification and characterization of the human SOX6 promoter.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257
6506  Huang BL, Dornbach LM, Lyons KM.  The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.  J Cell Commun Signal  2007  1(1):17-32  PubMed ID: 18481207
6507  Takeuchi S, Mukai N, Tateishi T, Miyakawa S.  Production of sex steroid hormones from DHEA in articular chondrocyte of rats.  Am J Physiol Endocrinol Metab  2007  293(1):E410-5  PubMed ID: 17473054
6509  Ishii I, Mizuta H, Sei A, Hirose J, Kudo S, Hiraki Y.  Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.  J Bone Joint Surg Br  2007  89(5):693-700  PubMed ID: 17540759
4863  Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.  Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5.  J Bone Miner Metab  2006  24(2):153-7  PubMed ID: 16502123
6478  Nakatani S, Mano H, Ryanghyok IM, Shimizu J, Wada M.  Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.  Biochem Biophys Res Commun  2006  348(3):1157-62  PubMed ID: 16904632
6479  Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.  The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.  Calcif Tissue Int  2006  78(3):171-7  PubMed ID: 16523220
6481  Reinhold MI, Kapadia RM, Liao Z, Naski MC.  The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis.  J Biol Chem  2006  281(3):1381-8  PubMed ID: 16293629
6482  Kanda Y1, Hisayasu S, Fukai F, Takase B.  Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms.  Life Sci  2006  78(6):640-8  PubMed ID: 16111716
6483  Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, Ikegawa S.  Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene.  Biochem Biophys Res Commun  2006  341(1):121-7  PubMed ID: 16413503
6484  Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.  Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.  Eur J Pharmacol  2006  542(1-3):48-53  PubMed ID: 16828741
6485  Stewart AJ, Houston B, Farquharson C.  Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.  J Cell Physiol  2006  206(2):435-40  PubMed ID: 16155924
6486  Phornphutkul C, Wu KY, Gruppuso PA.  The role of insulin in chondrogenesis.  Mol Cell Endocrinol  2006  249(1-2):107-15  PubMed ID: 16530934
6487  Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y.  Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.  J Biol Chem  2006  281(33):23632-42  PubMed ID: 16777848
6488  Chen L, Fink T, Ebbesen P, Zachar V.  Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions.  Tissue Eng  2006  12(3):559-67  PubMed ID: 16579689
6489  Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A.  TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.  Arthritis Res Ther  2006  8(5):R146  PubMed ID: 16945157
6490  Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.  Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.  J Biol Chem  2006  281(37):27229-41  PubMed ID: 16835229
6491  MacRae VE, Farquharson C, Ahmed SF.  The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.  J Endocrinol  2006  189(2):319-28  PubMed ID: 16648299
6492  MacRae VE, Burdon T, Ahmed SF, Farquharson C.  Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.  J Endocrinol  2006  191(2):369-77  PubMed ID: 17088406
2874  Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Biochem Biophys Res Commun  2005  333:1300-8  PubMed ID: 15979579
3120  Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446
3194  Hinoi E, Wang L, Takemori A, Yoneda Y.  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296
5399  Takumi Tamayama, Kentaro Maemura, Kiyoto Kanbara,Hana Hayasaki, Yasuaki Yabumoto, Masayoshi Yuasa,and Masahito Watanabe  Expression of GABAAand GABABreceptorsin rat growth plate chondrocytes: Activationof the GABA receptors promotes proliferationof mouse chondrogenic ATDC5 cells  Molecular and Cellular Biochemistry  2005  273:117–126 
4989  Kirimoto A1, Takagi Y, Ohya K, Shimokawa H.  Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5.  J Med Dent Sci  2005  52(3):153-62  PubMed ID: 16350840
5412  Chen L, Fink T, Zhang XY, Ebbesen P, Zachar V.  Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis.  Differentiation  2005  73(7):350-63  PubMed ID: 16219039
5972  Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R.  Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.  Biochem J  2005  389(Pt 2):315-23  PubMed ID: 15784009
6221  Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.  Hum Mol Genet  2005  14(8):1009-17  PubMed ID: 15746150
6230  Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.  Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.  J Cell Physiol  2005  204(3):927-33  PubMed ID: 15795936
6245  Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K.  Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.  Exp Cell Res  2005  310(2):256-69  PubMed ID: 16165127
4968  Okada A, Shiomi T, Aoki Y, Fujiwara M.  Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.  J Toxicol Sci  2005  30(3):145-56  PubMed ID: 16141649
6222  Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P.  GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton.  Bone  2005  37(2):139-47  PubMed ID: 15946906
6871  Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG.  Regulation of the human Sox9 promoter by the CCAAT-binding factor.  Matrix Biol   2005  24(3):185-97  PubMed ID: 15908194
3158  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495
2899  Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  J Cell Biol  2004  166:85-95  PubMed ID: 15226309
2926  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410
2900  Nakajima M, Negishi Y, Tanaka H, Kawashima K.  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198
3330  Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Molecular recognition of BMP-2 and BMP receptor IA.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755
6247  Fujita T, Fukuyama R, Enomoto H, Komori T.  Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.  J Cell Biochem  2004  93(2):374-83  PubMed ID: 15368363
6294  Yamagiwa H, Yamada Y, Bolander ME, Sarkar G.  Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell.  Mol Biotechnol  2004  28(1):1-8  PubMed ID: 15456958
6306  Madhavi Ayyalasomayajula , Sydha Salihu , Vincent Kish , Nilay Mukherjee  Influence of Rearrangement of Actin Cytoskeleton on the Overall Material Properties of ATDC5 Cells During Chondrogenesis  ASME 2004 International Mechanical Engineering Congress and Exposition  2004  359-360 
6345  Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F.  Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.  Biochem Biophys Res Commun  2004  315(2):272-80  PubMed ID: 14766204
6373  Yamagiwa H, Bolander ME, Sarkar G.  Evaluation of different conditions for ligating dumbbell-shaped oligonucleotides.  Mol Biotechnol  2004  26(2):111-6  PubMed ID: 14764936
6375  Jayendran Srinivasan , Vincent Kish , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  Poking Cells in Cell-Gel Constructs: A Potential Way of Measuring Fluid Pressure in Cells  ASME 2004 International Mechanical Engineering Congress and Exposition  2004  361-362 
3591  Hidaka K, Kanematsu T, Caffrey JJ, Takeuchi H, Shears SB, Hirata M.  The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.  Exp Cell Res  2003  290(2):254-64  PubMed ID: 14567985
3549  Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y.  PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.  J Bone Miner Res  2003  18(8):1395-403  PubMed ID: 12929929
4777  Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Kim HJ, Ryoo HM.  BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.  J Biol Chem  2003  278(36):34387-94. Epub 2003 Jun 18  PubMed ID: 12815054
4820  Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K.  Suppression of differentiation and proliferation of early chondrogenic cells by Notch.  J Bone Miner Metab  2003  21(6):344-52  PubMed ID: 14586790
4874  Nishiyama T, Hatano H, Kurosaka M, Bolander ME, Sarkar G.  Cis-acting intronic elements that regulate cartilage-specific alternative splicing of the type II collagen (Col2) pre-mRNA lie at or near splice site junction sequences flanking exon 2 of the gene.  J Bone Miner Res  2003  18(9):1716-22  PubMed ID: 12968682
4908  Shinsuke Aoki et al  A new approach to an artificial joint based on bio-cartilage/porous β-tricalcium phosphate system  Journal of the European Ceramic Society  2003  23:2939-2946 
4937  Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung UI, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H.  Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.  J Biol Chem  2003  278(48):48259-66  PubMed ID: 13679380
4944  Oda R, Suardita K, Fujimoto K, Pan H, Yan W, Shimazu A, Shintani H, Kato Y.  Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.  J Cell Sci  2003  116(Pt 10):2029-38  PubMed ID: 12679380
4978  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046
3555  Nishigaki F, Sakuma S, Ogawa T, Miyata S, Ohkubo T, Goto T.  FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5.  Eur J Pharmacol  2002  437(3):123-8  PubMed ID: 11890899
3556  Suda M, Tanaka K, Yasoda A, Komatsu Y, Chusho H, Miura M, Tamura N, Ogawa Y, Nakao K.  C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line.  J Bone Miner Metab  2002  20(3):136-41  PubMed ID: 11984695
3557  Tezuka K, Yasuda M, Watanabe N, Morimura N, Kuroda K, Miyatani S, Hozumi N.  Stimulation of osteoblastic cell differentiation by Notch.  J Bone Miner Res  2002  17(2):231-9  PubMed ID: 11811553
3558  Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y.  Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.  J Biol Chem  2002  277(51):50112-20  PubMed ID: 12384505
3560  Fujita T, Meguro T, Fukuyama R, Nakamuta H, Koida M.  New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.  J Biol Chem  2002  277(25):22191-200  PubMed ID: 11956184
3561  Jayendran Srinivasan , Vincent Kish , Vidyashankar Venkatesan , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  Material Properties of Cells Can Be Determined From Compression Experiments of Cell-Gel Constructs  ASME 2002 International Mechanical Engineering Congress and Exposition  2002  47-48 
3563  Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H.  Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10.  J Biol Chem  2002  277(9):7493-500  PubMed ID: 11741978
3566  Suardita K, Fujimoto K, Oda R, Shimazu A, Miyazaki K, Kawamoto T, Kato Y.  Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in Vitro.  J Biol Chem  2002  277(50):48579-86  PubMed ID: 12374788
3568  Ganss B, Kobayashi H.  The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation.  J Bone Miner Res  2002  17(12):2151-60  PubMed ID: 12469909
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