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Cell No. : Cell Name
RCB0565 : ATDC5  update : 2024/07/22
CommentDifferentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Atsumi, Tadao
Originator Atsumi, Tadao
Year of deposit 1991
Original cell AT805
Animal _mouse < Mammals
Strain name 129
Gender Male
Age at sampling embryo
Tissue embryo
Disease name Teratocarcinoma AT805 derived
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3894
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM/HamF12 + 5% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Reference information Reference 5
User's Publication 491

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1682  Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, Atsumi T, Umezawa A, Kudo A, Kitayama H, Hiraki Y, Noda M.  Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.  J Cell Sci  2007  120(Pt 5):849-57  PubMed ID: 17298979   DOI: 10.1242/jcs.03388
1681  Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y.  Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro.  J Bone Miner Res  1997  12(8):1174-88  PubMed ID: 9258747   DOI: 10.1359/jbmr.1997.12.8.1174
1687  Shukunami C, Shigeno C, Atsumi T, Ishizeki K, Suzuki F, Hiraki Y.  Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.  J Cell Biol  1996  133(2):457-68  PubMed ID: 8609176   DOI: 10.1083/jcb.133.2.457
1688  Atsumi T, Miwa Y, Kimata K, Ikawa Y  A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.  Cell Differ Dev  1990  30:109-16  PubMed ID: 2201423   DOI: 10.1016/0922-3371(90)90079-c
2605  Takeichi M, Atsumi T, Yoshida C, Uno K, Okada, T S  Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites.  Dev Growth Differ  1981  87:340-350  PubMed ID: 6793433   DOI: 10.1016/0012-1606(81)90157-3

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User's Publication
19868  Shi L, Ura K, Takagi Y.  Effects of self-assembled type II collagen fibrils on the morphology and growth of pre-chondrogenic ATDC5 cells  Osteoarthr Cartil Open  2024  6(2):100450  PubMed ID: 38444516   DOI: 10.1016/j.ocarto.2024.100450
21646  Hong X, Liu X, Li B, Shi S, Xiao K, Xu T, Nie Y, Dai M, Zhu M.  Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways.  J Orthop Surg Res  2024  19(1):188  PubMed ID: 38500177   DOI: 10.1186/s13018-024-04640-z
21665  Li Q, Yang Z, Zhu M, Zhang W, Chen L, Chen H, Kang P.  Hypobaric hypoxia aggravates osteoarthritis via the alteration of the oxygen environment and bone remodeling in the subchondral zone.  FASEB J  2024  38(7):e23594  PubMed ID: 38573451   DOI: 10.1096/fj.202302368R
21721  Tsuboi E, Asakawa Y, Hirose N, Yanoshita M, Sumi C, Takano M, Onishi A, Nishiyama S, Kubo N, Kita D, Tanimoto K.  The role of semaphorin 3A on chondrogenic differentiation.  In Vitro Cell Dev Biol Anim  2024    PubMed ID: 38727898   DOI: 10.1007/s11626-024-00909-z
21774  Kawamura S, Furuya K, Sasaki N, Takeoka Y, Aizawa M, Kanzawa N.  Evaluation of alginate-coated β-tricalcium phosphate fiber scaffold for cell culture.  J Biomed Mater Res B Appl Biomater  2024  112(6):e35433  PubMed ID: 38817048   DOI: 10.1002/jbm.b.35433
21798  Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R.  Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.  JCI Insight  2024  9(11)  PubMed ID: 38855864   DOI: 10.1172/jci.insight.175486
17758  Franco-Trepat E, Alonso-Pérez A, Guillán-Fresco M, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Belén Bravo S, López-López V, Jorge-Mora A, Cerón-Carrasco JP, Lois Iglesias A, Gómez R.  β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine  Antioxidants (Basel)  2023  12(2):371  PubMed ID: 36829930   DOI: 10.3390/antiox12020371
19565  Shunsuke Hirashima, Shinichiro Kaetsu, Yukino Kiyooka, Kimie Nakagawa  Vitamin K Converting Enzyme UBIAD1 Promotes the Proliferation and Differentiation of Mouse Chondrogenic ATDC5 Cells  BPB Reports  2023  6:176-182    DOI: 10.1248/bpbreports.6.6_176
19587  Wang H, Wu Z, Xu K.  CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5  Exp Ther Med  2023  25(6):303  PubMed ID: 37229323   DOI: 10.3892/etm.2023.12002
19870  Farrag Y, Ait Eldjoudi D, Farrag M, González-Rodríguez M, Ruiz-Fernández C, Cordero A, Varela-García M, Torrijos Pulpón C, Bouza R, Lago F, Pino J, Alvarez-Lorenzo C, Gualillo O.  Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage  Polymers (Basel)  2023  15(24):4635  PubMed ID: 38139888   DOI: 10.3390/polym15244635
19886  Guillán-Fresco M, Franco-Trepat E, Alonso-Pérez A, Jorge-Mora A, López-López V, Pazos-Pérez A, Piñeiro-Ramil M, Gómez R.  Formononetin, a Beer Polyphenol with Catabolic Effects on Chondrocytes  Nutrients  2023  15(13):2959  PubMed ID: 37447284   DOI: 10.3390/nu15132959
19894  Kimira Y, Sato T, Sakamoto M, Osawa Y, Mano H.  Collagen-Derived Dipeptide Pro-Hyp Enhanced ATDC5 Chondrocyte Differentiation under Hypoxic Conditions  Molecules  2023  28(12):4664  PubMed ID: 37375217   DOI: 10.3390/molecules28124664
19931  van Kampen KA, Olaret E, Stancu IC, Duarte Campos DF, Fischer H, Mota C, Moroni L.  Hypotrochoidal scaffolds for cartilage regeneration  Mater Today Bio  2023  23:100830  PubMed ID: 37876709   DOI: 10.1016/j.mtbio.2023.100830
19932  Alizadeh Sardroud H, Chen X, Eames BF.  Applied Compressive Strain Governs Hyaline-like Cartilage versus Fibrocartilage-like ECM Produced within Hydrogel Constructs  Int J Mol Sci  2023  24(8):7410  PubMed ID: 37108575   DOI: 10.3390/ijms24087410
19934  Hafeez S, Decarli MC, Aldana A, Ebrahimi M, Ruiter FAA, Duimel H, van Blitterswijk C, Pitet LM, Moroni L, Baker MB.  In Situ Covalent Reinforcement of a Benzene-1,3,5-Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks  Adv Mater  2023  35(35):e2301242  PubMed ID: 37370137   DOI: 10.1002/adma.202301242
19951  Xu J, Zhi X, Zhang Y, Ding R.  Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis  Open Life Sci  2023  18(1):20220666  PubMed ID: 37589005   DOI: 10.1515/biol-2022-0666
21012  Yang X, Lin Y, Chen T, Hu W, Li P, Qiu X, Yang B, Liang A, Gao W.  YTHDF1 enhances chondrogenic differentiation by activating the Wnt/β-catenin signaling pathway.  Stem Cells Dev  2023    PubMed ID: 36647682   DOI: 10.1089/scd.2022.0216
21029  Kadoya K, Hara ES, Okada M, Jiao YY, Nakano T, Sasaki A, Matsumoto T.  Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments.  Regen Biomater  2023  10:rbac088  PubMed ID: 36683756   DOI: 10.1093/rb/rbac088
21049  Lyu J, Kubo T, Iwahashi S, Fukasawa K, Horie T, Nagamatsu K, Ikeno K, Nakamura G, Kamakura M, Hinoi E.  Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly.  Biol Pharm Bull  2023  46(2):348-353  PubMed ID: 36724964   DOI: 10.1248/bpb.b22-00654
21094  Hafeez S, Aldana A, Duimel H, Ruiter FAA, Decarli MC, Lapointe V, van Blitterswijk C, Moroni L, Baker MB.  Molecular tuning of a benzene-1,3,5-tricarboxamide supramolecular fibrous hydrogel enables control over viscoelasticity and creates tunable ECM-mimetic hydrogels and bioinks.  Adv Mater  2023  e2207053  PubMed ID: 36858040   DOI: 10.1002/adma.202207053
21217  Velentza L, Wickström M, Kogner P, Ohlsson C, Zaman F, Sävendahl L.  Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth.  Sci Rep  2023  13(1):8054  PubMed ID: 37198212   DOI: 10.1038/s41598-023-34965-4
21287  Alizadeh Sardroud H, Chen X, Eames BF.  Reinforcement of Hydrogels with a 3D-Printed Polycaprolactone (PCL) Structure Enhances Cell Numbers and Cartilage ECM Production under Compression.  J Funct Biomater  2023  14(6)  PubMed ID: 37367278   DOI: 10.3390/jfb14060313
21301  Okita K, Hikiji H, Koga A, Nagai-Yoshioka Y, Yamasaki R, Mitsugi S, Fujii W, Ariyoshi W.  Ascorbic acid enhances chondrocyte differentiation of ATDC5 by accelerating insulin receptor signaling.  Cell Biol Int  2023    PubMed ID: 37381608   DOI: 10.1002/cbin.12067
21303  Zhu M, Cao Z, Mo F, Shi S, Hu J, Xu Q, Quan K, Liang J, Li W, Hong X, Zhang B, Liu X, Dai M.  ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination.  Int J Biol Macromol  2023  125670  PubMed ID: 37406898   DOI: 10.1016/j.ijbiomac.2023.125670
21427  Ma JC, Luo T, Feng B, Huang Z, Zhang Y, Huang H, Yang X, Wen J, Bai X, Cui ZK.  Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy.  J Nanobiotechnology  2023  21(1):361  PubMed ID: 37794470   DOI: 10.1186/s12951-023-02118-4
21502  Zou K, Ying J, Xu H, Zeng Q, Huang H, Chen W, Li X, Wang P, Jin H, Li J, Wu Y.  Aucubin Alleviates Intervertebral Disc Degeneration by Repressing NF-κB-NLRP3 Inflammasome Activation in Endplate Chondrocytes.  J Inflamm Res  2023  16:5899-5913  PubMed ID: 38084106   DOI: 10.2147/JIR.S439981
17624  Tateiwa D, Kaito T, Hashimoto K, Okada R, Kodama J, Kushioka J, Bal Z, Tsukazaki H, Nakagawa S, Ukon Y, Hirai H, Tian H, Alferiev I, Chorny M, Otsuru S, Okada S, Iwamoto M.  Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation  Front Cell Dev Biol  2022  10:802699  PubMed ID: 35359440   DOI: 10.3389/fcell.2022.802699
17653  Hafeez S, Passanha FR, Feliciano AJ, Ruiter FAA, Malheiro A, Lafleur RPM, Matsumoto NM, van Blitterswijk C, Moroni L, Wieringa P, LaPointe VLS, Baker MB.  Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D  Biomater Sci  2022  10:4740-4755  PubMed ID: 35861034   DOI: 10.1039/d2bm00312k
17673  Liu C, Chen Y.  Ketorolac tromethamine alleviates IL-1β-induced chondrocyte injury by inhibiting COX-2 expression  Exp Ther Med  2022  ;23(5):337.  PubMed ID: 35411209   DOI: 10.3892/etm.2022.11267
17705  Zhang Z, Yang P, Wang C, Tian R.  LncRNA CRNDE hinders the progression of osteoarthritis by epigenetic regulation of DACT1  Cell Mol Life Sci  2022  79(8):405  PubMed ID: 35802196   DOI: 10.1007/s00018-022-04427-7
17759  Lesage R, Ferrao Blanco MN, Narcisi R, Welting T, van Osch GJVM, Geris L.  An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis  BMC Biol  2022  20(1):253  PubMed ID: 36352408   DOI: 10.1186/s12915-022-01451-8
20540  Zhang Q, Bai X, Wang R, Zhao H, Wang L, Liu J, Li M, Chen Z, Wang Z, Li L, Wang D.  4-octyl Itaconate inhibits lipopolysaccharide (LPS)-induced osteoarthritis via activating Nrf2 signalling pathway.  J Cell Mol Med  2022    PubMed ID: 35068055   DOI: 10.1111/jcmm.17185
20552  Sadeghianmaryan A, Naghieh S, Yazdanpanah Z, Sardroud HA, Sharma NK, Wilson LD, Chen X.  Fabrication of chitosan/alginate/hydroxyapatite hybrid scaffolds using 3D printing and impregnating techniques for potential cartilage regeneration.  Int J Biol Macromol  2022    PubMed ID: 35124017   DOI: 10.1016/j.ijbiomac.2022.01.201
20568  Feng X, Lu J, Wu Y, Xu H.  MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1.  J Physiol Sci  2022  72(1):3  PubMed ID: 35148687   DOI: 10.1186/s12576-022-00827-3
16217  Rong Li, Zijing Guan, Shuyan Bi, Fanhua Wang, Liang He, Xin Niu, Yu You, Yuwei Liu, Yi Ding, Stefan Siwko, Ning Wang, Ziming Zhang, Yunyun Jin, Jian Luo  The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling  Cell Death Dis  2022  13(2):152  PubMed ID: 35165253   DOI: 10.1038/s41419-021-04455-4
16346  Hasenbein I, Sachse A, Hortschansky P, Schmuck KD, Horbert V, Anders C, Lehmann T, Huber R, Maslaris A, Layher F, Braun C, Roth A, Plöger F, Kinne RW.  Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model  Biomedicines  2022  10(2):513  PubMed ID: 35203721   DOI: 10.3390/biomedicines10020513
20591  Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP, Ma X, Wang X, Gartland A, Wang N, Shah KM, Zhang H, Cao X, Yang L, Liu M, Luo J.  A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.  Cell Discov  2022  8(1):24  PubMed ID: 35256606   DOI: 10.1038/s41421-022-00382-6
20611  Steinbusch MMF, van den Akker GGH, Cremers A, Witlox AMA, Staal HM, Peffers MJ, van Rhijn LW, Caron MMJ, Welting TJM.  Adaptation of the protein translational apparatus during ATDC5 chondrogenic differentiation.  Noncoding RNA Res  2022  7(2):55-65  PubMed ID: 35261930   DOI: 10.1016/j.ncrna.2022.02.003
20677  Ruiz-Fernández C, González-Rodríguez M, Abella V, Francisco V, Cordero-Barreal A, Ait Eldjoudi D, Farrag Y, Pino J, Conde-Aranda J, González-Gay MÁ, Mera A, Mobasheri A, García-Caballero L, Gándara-Cortés M, Lago F, Scotece M, Gualillo O.  WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.  Lab Invest  2022    PubMed ID: 35484291   DOI: 10.1038/s41374-022-00793-9
16755  Shimohata N, Harada Y, Hayano T.  Proteomic analysis of nascent polypeptide chains that potentially induce translational pausing during elongation  Biosci Biotechnol Biochem  2022  zbac097  PubMed ID: 35749475   DOI: 10.1093/bbb/zbac097
20762  Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ.  Mast4 determines the cell fate of MSCs for bone and cartilage development.  Nat Commun  2022  13(1):3960  PubMed ID: 35803931   DOI: 10.1038/s41467-022-31697-3
20789  Liao Y, Ren Y, Luo X, Mirando AJ, Long JT, Leinroth A, Ji RR, Hilton MJ.  Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.  Sci Signal  2022  15(744):eabn7082  PubMed ID: 35881692   DOI: 10.1126/scisignal.abn7082
20810  Tanaka M, Miyamoto Y, Sasa K, Yoshimura K, Yamada A, Shirota T, Kamijo R.  Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1ß.  In Vitro Cell Dev Biol Anim  2022    PubMed ID: 35925448   DOI: 10.1007/s11626-022-00680-z
20813  Kim J, Tomida K, Matsumoto T, Adachi T.  Spheroid culture for chondrocytes triggers early stage of endochondral ossification.  Biotechnol Bioeng  2022    PubMed ID: 35923099   DOI: 10.1002/bit.28203
20847  Franco-Trepat E, Guillán-Fresco M, Alonso-Pérez A, López-Fagúndez M, Pazos-Pérez A, Crespo-Golmar A, Gualillo O, Jorge-Mora A, Bravo SB, Gómez R.  Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells.  Biomed Pharmacother  2022  155:113671  PubMed ID: 36108390   DOI: 10.1016/j.biopha.2022.113671
20861  Niu J, Wan X, Yu GY, Jiang S, Yi RN, Wu YP, Ouyang SH, Liang L, Kurihara H, Sun WY, Zhu XF, Zhang RH, Cao YF, He JB, Duan WJ, Li YF, He RR.  Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.  Redox Biol  2022  56:102437  PubMed ID: 36037588   DOI: 10.1016/j.redox.2022.102437
20871  Kikuchi K, Haneda M, Hayashi S, Maeda T, Nakano N, Kuroda Y, Tsubosaka M, Kamenaga T, Fujita M, Ikuta K, Anjiki K, Tachibana S, Onoi Y, Matsumoto T, Kuroda R.  P21 deficiency exhibits delayed endochondral ossification during fracture healing.  Bone  2022  116572  PubMed ID: 36180020   DOI: 10.1016/j.bone.2022.116572
21048  Kitaura Y, Nakamura U, Awada C, Yamaguchi M, Kim M, Ikeda Y, Matsuo Y, Moriishi T, Sawase T, Chung UI, Hojo H, Ohba S.  Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models.  Regen Ther  2022  21:584-595  PubMed ID: 36475024   DOI: 10.1016/j.reth.2022.11.002
17757  Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T.  Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2  Commun Biol  2021  4(1):326  PubMed ID: 33707608   DOI: 10.1038/s42003-021-01848-1
13061  Semba S, Kitamura N, Tsuda M, Goto K, Kurono S, Ohmiya Y, Kurokawa T, Gong JP, Yasuda K, Tanaka S.  Synthetic poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function.  J Biomed Mater Res A  2021    PubMed ID: 32496623   DOI: 10.1002/jbm.a.37028
13408  Wang B, Sun W, Bi K, Li Y, Li F.  Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1.  Int J Mol Med  2021    PubMed ID: 33448323   DOI: 10.3892/ijmm.2021.4845
13441  Kai Li Panpan Yang Yuwei Zhang Yue Zhang He Cao Peilin Liu Bin Huang Song Xu Pinglin Lai Guanghua Lei Jia Liu Yujin Tang Xiaochun Bai Zhipeng Zou  DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes  J Bone Miner Res  2021  36(2):400-411  PubMed ID: 32916025   DOI: 10.1002/jbmr.4176
13533  Takano I, Takeshita N, Yoshida M, Seki D, Oyanagi T, Kimura S, Jiang W, Sasaki K, Sogi C, Kawatsu M, Takano-Yamamoto T.  Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization  J Cell Physiol  2021  236(4):2906-2919  PubMed ID: 32960451   DOI: 10.1002/jcp.30058
13544  Caron MMJ, van Rietbergen B, Castermans TMR, Haartmans MJJ, van Rhijn LW, Welting TJM, Witlox AMA.  Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents  J Orthop Res  2021  39(3):553-564  PubMed ID: 32740982   DOI: 10.1002/jor.24819
13588  Maenohara Y, Chijimatsu R, Tachibana N, Uehara K, Xuan F, Mori D, Murahashi Y, Nakamoto H, Oichi T, Chang SH, Matsumoto T, Omata Y, Yano F, Tanaka S, Saito T.  Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells  J Bone Miner Res  2021  36(4):792-802  PubMed ID: 33617044   DOI: 10.1002/jbmr.4226
20192  Kitagawa A, Yamaguchi M, Fujiwara A, Shimizu M, Takahashi A, Sone H, Kamiyama S.  Genistein inhibits chondrogenic differentiation and mineralization of ATDC5 cells.  Biochem Biophys Res Commun  2021  566:123-128  PubMed ID: 34119824   DOI: 10.1016/j.bbrc.2021.05.101
20237  Jokoji G, Maeda S, Oishi K, Ijuin T, Nakajima M, Tawaratsumida H, Kawamura I, Tominaga H, Taketomi E, Ikegawa S, Taniguchi N.  CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1.  J Biol Chem  2021  100994  PubMed ID: 34298017   DOI: 10.1016/j.jbc.2021.100994
14887  Takano M, Hirose N, Sumi C, Yanoshita M, Nishiyama S, Onishi A, Asakawa Y, Tanimoto K.  ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes  Cartilage  2021  1947603519878242  PubMed ID: 31581797   DOI: 10.1177/1947603519878242
20256  Garcia de Vinuesa A, Sanchez-Duffhues G, Blaney-Davidson E, van Caam A, Lodder K, Ramos Y, Kloppenburg M, Meulenbelt I, van der Kraan P, Goumans MJ, Ten Dijke P.  Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis.  J Pathol  2021    PubMed ID: 34357595   DOI: 10.1002/path.5774
15282  Jin Liu, Xiaohao Wu, Jun Lu, Guangxin Huang, Lei Dang, Huarui Zhang, Chuanxin Zhong, Zongkang Zhang, Dijie Li, Fangfei Li, Chao Liang, Yuanyuan Yu, Bao-Ting Zhang, Lin Chen, Aiping Lu, Ge Zhang  Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression  Nature Aging  2021  1:368-384    DOI: 10.1038/s43587-021-00050-6
15526  Caron MMJ, Eveque M, Cillero-Pastor B, Heeren RMA, Housmans B, Derks K, Cremers A, Peffers MJ, van Rhijn LW, van den Akker G, Welting TJM.  Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins  Front Cell Dev Biol  2021  9:686096  PubMed ID: 34235151   DOI: 10.3389/fcell.2021.686096
20444  Roh HH, Kim HS, Kim C, Lee KY.  3D Printing of Polysaccharide-Based Self-Healing Hydrogel Reinforced with Alginate for Secondary Cross-Linking.  Biomedicines  2021  9(9)  PubMed ID: 34572410   DOI: 10.3390/biomedicines9091224
16284  Zhu M, Xu Q, Yang X, Zhan H, Zhang B, Liu X, Dai M.  Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts  Front Pharmacol  2021  12:764598  PubMed ID: 35095488   DOI: 10.3389/fphar.2021.764598
16746  Sun M, Wang W, Min L, Chen C, Li Q, Weng W.  Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway  J Orthop Surg Res  2021  16(1):129  PubMed ID: 33573682   DOI: 10.1186/s13018-021-02260-5
16762  Wang W, Zhu Y, Sun Z, Jin C, Wang X.  Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling  Arthritis Res Ther  2021  23(1):84  PubMed ID: 33726807   DOI: 10.1186/s13075-021-02456-4
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6469  Villalvilla A, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.  6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity.  Mol Nutr Food Res  2014  58(2):256-66  PubMed ID: 24039109   DOI: 10.1002/mnfr.201200833
3517  Kosaka T, Fukui R, Matsui M, Kurosaka Y, Nishimura H, Tanabe M, Takakura Y, Iwai K, Waki T, Fujita T.  RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.  PLoS One  2014  9(9):e108819  PubMed ID: 25275461   DOI: 10.1371/journal.pone.0108819
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6580  Kitamura N, Kurokawa T, Fukui T, Gong JP, Yasuda K.  Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells.  BMC Musculoskelet Disord  2014  15:222  PubMed ID: 24997593   DOI: 10.1186/1471-2474-15-222
6581  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.  High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.  J Orthop Res  2014  32(12):1619-27  PubMed ID: 25196420   DOI: 10.1002/jor.22691
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6588  Hida M, Hamanaka R, Okamoto O, Yamashita K, Sasaki T, Yoshioka H, Matsuo N.  Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.  In Vitro Cell Dev Biol Anim  2014  50(4):358-66  PubMed ID: 24092017   DOI: 10.1007/s11626-013-9692-3
6589  Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.  LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.  Biochem Biophys Res Commun  2014  451(2):302-7  PubMed ID: 25091481   DOI: 10.1016/j.bbrc.2014.07.125
6590  Gómez R, Conde J, Scotece M, López V, Lago F, Gómez Reino JJ, Gualillo O.  Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes.  J Orthop Res  2014  32(9):1137-46  PubMed ID: 24902823   DOI: 10.1002/jor.22660
6591  Mori Y, Mori D, Chung UI, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T.  S100A1 and S100B are dispensable for endochondral ossification during skeletal development.  Biomed Res  2014  35(4):243-50  PubMed ID: 25152033   DOI: 10.2220/biomedres.35.243
6592  Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.  Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.  PLoS One  2014  9(3):e91421  PubMed ID: 24618907   DOI: 10.1371/journal.pone.0091421
6593  Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K  Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes.  J Biol Chem  2014  289(20):13810-20  PubMed ID: 24711445   DOI: 10.1074/jbc.M113.543322
6594  Staines KA, Zhu D, Farquharson C, MacRae VE.  Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.  J Bone Miner Metab  2014  32(3):240-51  PubMed ID: 23925391   DOI: 10.1007/s00774-013-0493-2
6595  Bergmann CJ1, Odekerken JC2, Welting TJ2, Jungwirth F, Devine D3, Bouré L3, Zeiter S3, van Rhijn LW2, Telle R4, Fischer H1, Emans PJ2.  Calcium phosphate based three-dimensional cold plotted bone scaffolds for critical size bone defects.  Biomed Res Int  2014  2014:852610  PubMed ID: 24719891   DOI: 10.1155/2014/852610
6596  Ushijima T, Okazaki K, Tsushima H, Ishihara K, Doi T, Iwamoto Y.  CCAAT/enhancer binding protein β regulates expression of Indian hedgehog during chondrocytes differentiation.  PLoS One  2014  9(8):e104547  PubMed ID: 25105964   DOI: 10.1371/journal.pone.0104547
6597  Woo E, Park H, Lee KY.  Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration.  Macromol Biosci  2014  14(5):740-8  PubMed ID: 24436180   DOI: 10.1002/mabi.201300365
6598  Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT.  Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.  PLoS One  2014  9(3):e92194  PubMed ID: 24637783   DOI: 10.1371/journal.pone.0092194
6599  Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.  Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.  PLoS One  2014  9(3):e92699  PubMed ID: 24658359   DOI: 10.1371/journal.pone.0092699
6600  Hatta T, Kishimoto KN, Okuno H, Itoi E.  Oxygen tension affects lubricin expression in chondrocytes.  Tissue Eng Part A  2014  20(19-20):2720-7  PubMed ID: 24712343   DOI: 10.1089/ten.TEA.2013.0353
6601  Jasmin L. Whittaker a, Namita R. Choudhury, Naba K. Dutta and Andrew Zannettino    J Mater Chem B  2014  2:6259-6270  PubMed ID: 32262143   DOI: 10.1039/C4TB00698D
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6603  Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme NJ, Haines P, Chen Q.  Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy and aberrant response to TGF-β in chondroprogenitor cells.  Int J Mol Sci  2014  15(8):14555-73  PubMed ID: 25196597   DOI: 10.3390/ijms150814555
6604  Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.  J Biol Chem  2014  89(14):9865-79  PubMed ID: 24563464   DOI: 10.1074/jbc.M113.520585
6605  Inagaki Y, Kitamura N, Kurokawa T, Tanaka Y, Gong JP, Yasuda K, Tohyama H.  Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study.  BMC Musculoskelet Disord  2014  15:320  PubMed ID: 25262146   DOI: 10.1186/1471-2474-15-320
6606  Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.  J Biol Chem  2014  289(12):8135-50  PubMed ID: 24505141   DOI: 10.1074/jbc.M113.509331
6607  Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.  Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.  Neurochem Int  2014  74:24-35  PubMed ID: 24768841   DOI: 10.1016/j.neuint.2014.04.010
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6464  Gómez R, Scotece M, Conde J, Lopez V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O.  Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes.  J Orthop Res  2013  31(7):1046-52  PubMed ID: 23483583   DOI: 10.1002/jor.22331
6465  Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.  Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.  J Biol Chem  2013  288(40):28620-9  PubMed ID: 23963448   DOI: 10.1074/jbc.M113.452169
6556  Nepal M, Li L, Cho HK, Park JK, Soh Y.  Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway.  Food Chem Toxicol  2013  62:238-45  PubMed ID: 23989061   DOI: 10.1016/j.fct.2013.08.034
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6558  Hu-Hui Lee, Jing-Yu Lee & Lan-Hsin   Proper Fhl1 expression as Wnt signaling is required for chondrogenesis of ATDC5 cells  Animal Cells and Systems  2013  17:413-420    DOI: 10.1080/19768354.2013.856341
6559  Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R.  Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells.  Cell Tissue Res  2013  352(2):401-12  PubMed ID: 23274552   DOI: 10.1007/s00441-012-1548-8
6560  Mitani K1 Haruyama N, Hatakeyama J, Igarashi K.  Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells.  Oral Dis  2013  19(2):169-79  PubMed ID: 22863294   DOI: 10.1111/j.1601-0825.2012.01967.x
6561  Morimoto H, Baba R, Haneji T, Doi Y.  Double-stranded RNA-dependent protein kinase regulates insulin-stimulated chondrogenesis in mouse clonal chondrogenic cells, ATDC-5.  Cell Tissue Res  2013  351(1):41-7  PubMed ID: 23180319   DOI: 10.1007/s00441-012-1521-6
6562  Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.  Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.  J Pharmacol Sci  2013  122(4):318-25  PubMed ID: 23883486   DOI: 10.1254/jphs.13091fp
6563  Yoshikawa K, Kitamura N, Kurokawa T, Gong JP, Nohara Y, Yasuda K.  Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.  BMC Musculoskelet Disord  2013  14:56  PubMed ID: 23379610   DOI: 10.1186/1471-2474-14-56
6564  Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.  Proc Natl Acad Sci U S A  2013  110(5):1875-80  PubMed ID: 23319657   DOI: 10.1073/pnas.1207458110
6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878   DOI: 10.1002/art.37779
6566  Kwon HJ.  ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.  Cell Biochem Funct  2013  31(1):75-81  PubMed ID: 22886426   DOI: 10.1002/cbf.2862
6567  Lambrechts D, Roeffaers M, Kerckhofs G, Roberts SJ, Hofkens J, Van de Putte T, Van Oosterwyck H, Schrooten J.  Fluorescent oxygen sensitive microbead incorporation for measuring oxygen tension in cell aggregates.  Biomaterials  2013  34(4):922-9  PubMed ID: 23122803   DOI: 10.1016/j.biomaterials.2012.10.019
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6569  Zheng Z, Ren L, Zhai Z, Wang Y, Hang F.  Surface modification on polyethylene terephthalate films with 2-methacryloyloxyethyl phosphorylcholine.  Mater Sci Eng C Mater Biol Appl  2013  33(5):3041-6  PubMed ID: 23623130   DOI: 10.1016/j.msec.2013.03.036
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6420  Hu J, Hou Y, Park H, Lee M.  Beta-tricalcium phosphate particles as a controlled release carrier of osteogenic proteins for bone tissue engineering.  J Biomed Mater Res A  2012  100(7):1680-6  PubMed ID: 22447727   DOI: 10.1002/jbm.a.34115
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6472  Mitsugi S, Ariyoshi W, Okinaga T, Kaneuji T, Kataoka Y, Takahashi T, Nishihara T.  Mechanisms involved in inhibition of chondrogenesis by activin-A.  Biochem Biophys Res Commun  2012  420(2):380-4  PubMed ID: 22425773   DOI: 10.1016/j.bbrc.2012.03.003
6473  Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P.  New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.  J Bone Miner Res  2012  27(2):429-42  PubMed ID: 21976273   DOI: 10.1002/jbmr.532
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6541  Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.  Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.  Biochem J  2012  443(3):789-98  PubMed ID: 22507129   DOI: 10.1042/BJ20112062
6542  Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y.  Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.  J Biol Chem  2012  287(40):33293-303  PubMed ID: 22879594   DOI: 10.1074/jbc.M112.344051
6543  Kawamura I, Maeda S, Imamura K, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.  SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.  J Biol Chem  2012  287(34):29101-13  PubMed ID: 22767605   DOI: 10.1074/jbc.M112.349415
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6545  Kwon HJ.  TGF-β but not BMP signaling induces prechondrogenic condensation through ATP oscillations during chondrogenesis.  Biochem Biophys Res Commun  2012  424(4):793-800  PubMed ID: 22814106   DOI: 10.1016/j.bbrc.2012.07.041
6546  Zhiwen Zheng et al  Surface characterization of polyethylene terephthalate films treated by ammonia low-temperature plasma  Applied Surface Science  2012  258:7207-7212    DOI: 10.1016/j.apsusc.2012.04.038
6547  Andrés-Bergós J, Tardio L, Larranaga-Vera A, Gómez R, Herrero-Beaumont G, Largo R.  The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo.  J Biol Chem  2012  287(40):33615-28  PubMed ID: 22859309   DOI: 10.1074/jbc.M112.354241
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6549  Allen JL, Cooke ME, Alliston T.  ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.  Mol Biol Cell  2012  23(18):3731-42  PubMed ID: 22833566   DOI: 10.1091/mbc.E12-03-0172
6550  Hutchison MR.  BDNF alters ERK/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes.  Mol Endocrinol  2012  26(8):1406-16  PubMed ID: 22700586   DOI: 10.1210/me.2012-1063
6551  Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y.  Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.  PLoS One  2012  7(5):e37728  PubMed ID: 22629448   DOI: 10.1371/journal.pone.0037728
6552  Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y, Hinoi E, Yoneda Y.  Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts.  J Cell Physiol  2012  227(10):3477-87  PubMed ID: 22252936   DOI: 10.1002/jcp.24048
6553  Kwon HJ.  Extracellular ATP signaling via P2X(4) receptor and cAMP/PKA signaling mediate ATP oscillations essential for prechondrogenic condensation.  J Endocrinol  2012  214(3):337-48  PubMed ID: 22685336   DOI: 10.1530/JOE-12-0131
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7672  Endo T, Kobayashi T.  Thyroid-specific gene expression in chondrocytes.  Biochem. Biophys. Res. Commun.  2011  416:227-31  PubMed ID: 21945616   DOI: 10.1016/j.bbrc.2011.08.122
7760  Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Saamanen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M.  Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.  J. Biol. Chem.  2011  286:32140-9  PubMed ID: 21724852   DOI: 10.1074/jbc.M111.230110
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7805  Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C.  Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.  J. Bone Miner. Res.  2011  26:1230-41  PubMed ID: 21611965   DOI: 10.1002/jbmr.314
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7887  Yang CL, Chen HW, Wang TC, Wang YJ.  A novel fibrin gel derived from hyaluronic acid-grafted fibrinogen.  Biomed Mater  2011  6:025009  PubMed ID: 21393811   DOI: 10.1088/1748-6041/6/2/025009
7902  Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.  Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.  J. Biol. Chem.  2011  286:14744-52  PubMed ID: 21372137   DOI: 10.1074/jbc.M111.221259
7908  Shimada H, Sakakima H, Tsuchimochi K, Matsuda F, Komiya S, Goldring MB, Ijiri K.  Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice.  Pathol. Res. Pract.  2011  207:225-31  PubMed ID: 21353395   DOI: 10.1016/j.prp.2011.01.007
7912  Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.  Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.  Mol. Biol. Cell  2011  22:1300-11  PubMed ID: 21346191   DOI: 10.1091/mbc.E10-07-0566
7946  Takeshita N, Yoshimi E, Hatori C, Kumakura F, Seki N, Shimizu Y.  Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.  J. Pharmacol. Sci.  2011  115:481-9  PubMed ID: 21325780   DOI: 10.1254/jphs.10319fp
7962  Yoon HE, Kim KS, Kim IY.  14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell.  Biochem. Biophys. Res. Commun.  2011  406:59-63  PubMed ID: 21291861   DOI: 10.1016/j.bbrc.2011.01.107
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4791  Nishimura I, Chano T, Kita H, Matsusue Y, Okabe H.  RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.  J Biol Chem  2011  286(51):43925-32  PubMed ID: 22049074   DOI: 10.1074/jbc.M111.264192
4864  Kutsuna T, Inoue H, Takeda H, Takahashi T, Yamamoto H, Miura H, Higashiyama S.  Fibronectin regulates proteoglycan production balance in transforming growth factor-β1-induced chondrogenesis.  Int J Mol Med.  2011  28(5):829-34  PubMed ID: 21822533   DOI: 10.3892/ijmm.2011.766
8122  Choi BH, Choi YS, Kang DG, Kim BJ, Song YH, Cha HJ.  Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.  Biomaterials  2010  31:8980-8  PubMed ID: 20832110   DOI: 10.1016/j.biomaterials.2010.08.027
8222  Huang BL, Brugger SM, Lyons KM.  Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.  J. Biol. Chem.  2010  285:27702-12  PubMed ID: 20571031   DOI: 10.1074/jbc.M110.108498
8241  Temu TM, Wu KY, Gruppuso PA, Phornphutkul C.  The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.  Am. J. Physiol. Endocrinol. Metab.  2010  299:E325-34  PubMed ID: 20530736   DOI: 10.1152/ajpendo.00145.2010
8308  Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.  Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.  J. Bone Miner. Metab.  2010  28:627-33  PubMed ID: 20376510   DOI: 10.1007/s00774-010-0179-y
8343  Iacono A, Gomez R, Sperry J, Conde J, Bianco G, Meli R, Gomez-Reino JJ, Smith AB 3rd, Gualillo O.  Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line.  Arthritis Rheum.  2010  62:1675-82  PubMed ID: 20201078   DOI: 10.1002/art.27437
8347  Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa A, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.  Arthritis Rheum.  2010  62:826-36  PubMed ID: 20187155   DOI: 10.1002/art.27296
8353  Shirakura M, Tanimoto K, Eguchi H, Miyauchi M, Nakamura H, Hiyama K, Tanimoto K, Tanaka E, Takata T, Tanne K.  Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.  Biochem. Biophys. Res. Commun.  2010  393:800-5  PubMed ID: 20171183   DOI: 10.1016/j.bbrc.2010.02.086
8355  Kushibiki T, Tajiri T, Ninomiya Y, Awazu K.  Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation.  J. Photochem. Photobiol. B, Biol.  2010  98:211-5  PubMed ID: 20163967   DOI: 10.1016/j.jphotobiol.2010.01.008
8363  Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.  Increased expression of the hedgehog signaling pathway in pediatric solid malignancies.  J. Pediatr. Surg.  2010  45:387-92  PubMed ID: 20152358   DOI: 10.1016/j.jpedsurg.2009.10.081
8399  Noguchi K, Watanabe Y, Fuse T, Takizawa M.  A new chondrogenic differentiation initiator with the ability to up-regulate SOX trio expression.  J. Pharmacol. Sci.  2010  112:89-97  PubMed ID: 20051655   DOI: 10.1254/jphs.09254fp
8425  Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A.  Fibulin-3 negatively regulates chondrocyte differentiation.  Biochem. Biophys. Res. Commun.  2010  391:1116-21  PubMed ID: 20005202   DOI: 10.1016/j.bbrc.2009.12.034
8450  Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y.  Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.  Calcif. Tissue Int.  2010  86:47-57  PubMed ID: 19921088   DOI: 10.1007/s00223-009-9311-1
4605  Kwon HJ, Yasuda K, Ohmiya Y, Honma K, Chen YM, Gong JP.  In vitro differentiation of chondrogenic ATDC5 cells is enhanced by culturing on synthetic hydrogels with various charge densities.  Acta Biomater  2010  6(2):494-501  PubMed ID: 19651251   DOI: 10.1016/j.actbio.2009.07.033
4608  Takayama Y, Mizumachi K.  Inhibitory effect of lactoferrin on hypertrophic differentiation of ATDC5 mouse chondroprogenitor cells.  Biometals  2010  23(3):477-84  PubMed ID: 20094900   DOI: 10.1007/s10534-010-9291-7
4655  Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.  Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.  Int J Mol Med  2010  25(4):593-600  PubMed ID: 20198308   DOI: 10.3892/ijmm_00000381
4665  Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.  Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.  Nat Med  2010  16(6):678-86  PubMed ID: 20495570   DOI: 10.1038/nm.2146
4666  Yuan Li, Naoki Matsuda, Xu Xu Bao, Akira Teramoto, Koji Abe  The Development of Gelatin/Chitosan Hybrid Scaffold for Mouse Embryonic Stem Cell Line ATDC5  Advanced Materials Research  2010  123-125:395-398    DOI: 10.4028/
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4678  Hutchison MR1, Bassett MH, White PC.  SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation.  Mol Endocrinol  2010  24(1):193-203  PubMed ID: 19897599   DOI: 10.1210/me.2009-0228
4679  Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, Matsuda A, Takada K, Nishimura R, Yoneda T.  The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.  J Cell Sci  2010  123(Pt 21):3780-8  PubMed ID: 20940257   DOI: 10.1242/jcs.071373
8500  Owen HC, Ahmed SF, Farquharson C.  Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo.  Calcif. Tissue Int.  2009  85:326-34  PubMed ID: 19727539   DOI: 10.1007/s00223-009-9276-0
8545  Ti?li RS, Gumu?derelio?lu M.  Chondrogenesis on BMP-6 loaded chitosan scaffolds in stationary and dynamic cultures.  Biotechnol. Bioeng.  2009  104:601-10  PubMed ID: 19575410   DOI: 10.1002/bit.22426
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8559  Kishimoto KN, Oxford CL, Reddi AH.  Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia.  Cell Biol. Int.  2009  33:1222-9  PubMed ID: 19524690   DOI: 10.1016/j.cellbi.2009.06.009
8568  Gomez R, Lago F, Gomez-Reino JJ, Dieguez C, Gualillo O.  Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes.  Arthritis Rheum.  2009  60:1704-9  PubMed ID: 19479831   DOI: 10.1002/art.24522
8608  Gevers EF, Hannah MJ, Waters MJ, Robinson IC.  Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.  Endocrinology  2009  150:3627-36  PubMed ID: 19359380   DOI: 10.1210/en.2008-0985
8636  Nakamura Y, Takarada T, Kodama A, Hinoi E, Yoneda Y.  Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.  J. Pharmacol. Sci.  2009  109:413-23  PubMed ID: 19270431   DOI: 10.1254/jphs.08315fp
8646  Hayashida M, Okazaki K, Fukushi J, Sakamoto A, Iwamoto Y.  CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.  Arthritis Rheum.  2009  60:708-16  PubMed ID: 19248099   DOI: 10.1002/art.24332
8651  Kotzsch A, Nickel J, Seher A, Sebald W, Muller TD.  Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.  EMBO J.  2009  28:937-47  PubMed ID: 19229295   DOI: 10.1038/emboj.2009.37
8678  Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A.  A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification.  Arch. Histol. Cytol.  2009  72:175-85  PubMed ID: 20513980   DOI: 10.1679/aohc.72.175
8706  Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y.  A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect.  Macromol Biosci  2009  9:307-16  PubMed ID: 19031389   DOI: 10.1002/mabi.200800223
8713  Ti?li RS, Gumu?derelio?lu M.  Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds.  J Mater Sci Mater Med  2009  20:699-709  PubMed ID: 18987950   DOI: 10.1007/s10856-008-3624-x
6520  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C.  Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.  Am J Physiol Endocrinol Metab  2009  296(6):E1374-82  PubMed ID: 19401455   DOI: 10.1152/ajpendo.91018.2008
6531  Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.  Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.  Arthritis Rheum  2009  60(11):3314-23  PubMed ID: 19877062   DOI: 10.1002/art.24878
6532  Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung U, Nakamura K, Kawaguchi H.  Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.  Osteoarthritis Cartilage  2009  17(8):1065-75  PubMed ID: 19254740   DOI: 10.1016/j.joca.2009.02.003
6533  Arthritis Rheum  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917   DOI: 10.1002/art.24243
6534  Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A.  Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.  J Cell Biochem  2009  106(4):580-8  PubMed ID: 19142862   DOI: 10.1002/jcb.22029
6535  Heinecke K, Seher A, Schmitz W, Mueller TD, Sebald W, Nickel J.  Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.  BMC Biol  2009  7:59  PubMed ID: 19735544   DOI: 10.1186/1741-7007-7-59
6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746   DOI: 10.1186/1471-213X-9-70
6537  Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K. Author information  Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.  Nat Cell Biol  2009  11(10):1197-204  PubMed ID: 19767744   DOI: 10.1038/ncb1962
6538  Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T.  Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein.  Mol Biol Cell  2009  20(21):4541-51  PubMed ID: 19759178   DOI: 10.1091/mbc.e09-03-0227
6539  Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C.  Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.  J Cell Physiol  2009  218(2):276-84  PubMed ID: 18803233   DOI: 10.1002/jcp.21593
8784  Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD.  Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.  FEBS J.  2008  275:172-83  PubMed ID: 18070108   DOI: 10.1111/j.1742-4658.2007.06187.x
6510  Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y.  Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.  Genes Cells  2008  13(4):355-63  PubMed ID: 18363966   DOI: 10.1111/j.1365-2443.2008.01170.x
6511  Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.  A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.  J Mol Biol  2008  381(4):1025-39  PubMed ID: 18621057   DOI: 10.1016/j.jmb.2008.06.074
6512  Masuda T, Takahashi I, Anada T, Arai F, Fukuda T, Takano-Yamamoto T, Suzuki O.  Development of a cell culture system loading cyclic mechanical strain to chondrogenic cells.  J Biotechnol  2008  133(2):231-8  PubMed ID: 17904677   DOI: 10.1016/j.jbiotec.2007.08.007
6513  Galal N, El Beialy W, Deyama Y, Yoshimura Y, Yoshikawa T, Suzuki K, Totsuka Y.  Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements.  Int J Mol Med  2008  21(6):785-90  PubMed ID: 18506373  
6514  Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.  Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.  J Biol Chem  2008  283(39):26499-508  PubMed ID: 18632667   DOI: 10.1074/jbc.M800933200
6515  Tanne Y, Tanimoto K, Tanaka N, Ueki M, Lin YY, Ohkuma S, Kamiya T, Tanaka E, Tanne K.  Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation.  Arch Oral Biol  2008  53(5):478-87  PubMed ID: 18242579   DOI: 10.1016/j.archoralbio.2007.12.007
6516  Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T.  Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.  Osteoarthritis Cartilage  2008  16(6):723-32  PubMed ID: 18226559   DOI: 10.1016/j.joca.2007.10.014
6517  Takarada T, Hinoi E, Takahata Y, Yoneda Y.  Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.  J Cell Physiol  2008  215(2):320-8  PubMed ID: 17929246   DOI: 10.1002/jcp.21310
6518  Roberts SJ, Owen HC, Farquharson C.  Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.  Biochem Biophys Res Commun  2008  371(4):872-6  PubMed ID: 18471996   DOI: 10.1016/j.bbrc.2008.04.163
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373
6521  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.  Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.  J Biol Chem  2008  283(36):24682-9  PubMed ID: 18617520   DOI: 10.1074/jbc.M709857200
6522  Schugar RC, Robbins PD, Deasy BM.  Small molecules in stem cell self-renewal and differentiation.  Gene Ther  2008  15(2):126-35  PubMed ID: 17989703   DOI: 10.1038/
6523  Tiğli RS, Gümüşderelioğlu M.  Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity.  Int J Biol Macromol  2008  43(2):121-8  PubMed ID: 18485469   DOI: 10.1016/j.ijbiomac.2008.04.003
6524  Owen HC, Roberts SJ, Ahmed SF, Farquharson C.  Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.  Am J Physiol Endocrinol Metab  2008  294(6):E1023-34  PubMed ID: 18381927   DOI: 10.1152/ajpendo.00586.2007
12384  Boileau C, Poirier F, Pelletier JP, Guévremont M, Duval N, Martel-Pelletier J, Reboul P.  Intracellular localisation of galectin-3 has a protective role in chondrocyte survival  Ann Rheum Dis  2008  67(2):175-81  PubMed ID: 17545192   DOI: 10.1136/ard.2006.066514
18910  Dadsetan M, Szatkowski JP, Yaszemski MJ, Lu L.  Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering  Biomacromolecules  2007  8(5):1702-9  PubMed ID: 17419584   DOI: 10.1021/bm070052h
3584  Muramatsu S, Wakabayashi M, Ohno T, Amano K, Ooishi R, Sugahara T, Shiojiri S, Tashiro K, Suzuki Y, Nishimura R, Kuhara S, Sugano S, Yoneda T, Matsuda A.  Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.  J Biol Chem  2007  282(44):32158-67  PubMed ID: 17804410   DOI: 10.1074/jbc.M706158200
6167  Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH.  Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.  Dev Dyn  2007  236(5):1313-8  PubMed ID: 17436279   DOI: 10.1002/dvdy.21137
6494  Nakatani S, Mano H, Im R, Shimizu J, Wada M.  Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5.  Biol Pharm Bull  2007  30(3):433-8  PubMed ID: 17329833   DOI: 10.1248/bpb.30.433
6495  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.  The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.  Biomaterials  2007  28(3):434-40  PubMed ID: 16978693   DOI: 10.1016/j.biomaterials.2006.08.050
6496  Narukawa M, Suzuki N, Takayama T, Shoji T, Otsuka K, Ito K.  Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells.  J Periodontal Res  2007  42(2):131-7  PubMed ID: 17305871   DOI: 10.1111/j.1600-0765.2006.00926.x
6497  Huitema LF, van Weeren PR, van Balkom BW, Visser T, van de Lest CH, Barneveld A, Helms JB, Vaandrager AB.  Soluble factors released by ATDC5 cells affect the formation of calcium phosphate crystals.  Biochim Biophys Acta  2007  1774(9):1108-17  PubMed ID: 17669701   DOI: 10.1016/j.bbapap.2007.06.005
6498  Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S.  Mechanisms for asporin function and regulation in articular cartilage.  J Biol Chem  2007  282(44):32185-92  PubMed ID: 17827158   DOI: 10.1074/jbc.M700522200
6499  Macrae VE, Ahmed SF, Mushtaq T, Farquharson C.  IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.  Growth Horm IGF Res  2007  17(5):435-9  PubMed ID: 17590365   DOI: 10.1016/j.ghir.2007.05.002
6500  Hinoi E, Takarada T, Fujimori S, Wang L, Iemata M, Uno K, Yoneda Y.  Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.  Bone  2007  40(2):337-44  PubMed ID: 17029980   DOI: 10.1016/j.bone.2006.08.016
6501  Suemoto H, Muragaki Y, Nishioka K, Sato M, Ooshima A, Itoh S, Hatamura I, Ozaki M, Braun A, Gustafsson E, Fässler R.  Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.  Dev Biol  2007  312(2):572-81  PubMed ID: 17997399   DOI: 10.1016/j.ydbio.2007.10.001
6502  Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.  Novel function of TWEAK in inducing intervertebral disc degeneration.  J Orthop Res  2007  25(11):1438-46  PubMed ID: 17568422   DOI: 10.1002/jor.20445
6503  Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA.  Regulation of the human SOX9 promoter by Sp1 and CREB.  Exp Cell Res  2007  313(6):1069-79  PubMed ID: 17289023   DOI: 10.1016/j.yexcr.2007.01.001
6504  Owen HC, Miner JN, Ahmed SF, Farquharson C.  The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.  Mol Cell Endocrinol  2007  264(1-2):164-70  PubMed ID: 17182172   DOI: 10.1016/j.mce.2006.11.006
6505  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Identification and characterization of the human SOX6 promoter.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257   DOI: 10.1016/j.bbrc.2007.03.133
6506  Huang BL, Dornbach LM, Lyons KM.  The 5' untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity.  J Cell Commun Signal  2007  1(1):17-32  PubMed ID: 18481207   DOI: 10.1007/s12079-007-0003-1
6507  Takeuchi S, Mukai N, Tateishi T, Miyakawa S.  Production of sex steroid hormones from DHEA in articular chondrocyte of rats.  Am J Physiol Endocrinol Metab  2007  293(1):E410-5  PubMed ID: 17473054   DOI: 10.1152/ajpendo.00042.2007
6509  Ishii I, Mizuta H, Sei A, Hirose J, Kudo S, Hiraki Y.  Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant.  J Bone Joint Surg Br  2007  89(5):693-700  PubMed ID: 17540759   DOI: 10.1302/0301-620X.89B5.18450
4863  Noguchi A, Watanabe N, Fujimaki R, Kitamura T, Hayashizaki Y, Miyaki S, Tezuka K, Hozumi N.  Use of the SST-REX method for the identification of genes expressed at the condensation stage of chondrogenic cell line ATDC5.  J Bone Miner Metab  2006  24(2):153-7  PubMed ID: 16502123   DOI: 10.1007/s00774-005-0662-z
6478  Nakatani S, Mano H, Ryanghyok IM, Shimizu J, Wada M.  Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.  Biochem Biophys Res Commun  2006  348(3):1157-62  PubMed ID: 16904632   DOI: 10.1016/j.bbrc.2006.07.180
6479  Huitema LF, Vaandrager AB, van Weeren PR, Barneveld A, Helms JB, van de Lest CH.  The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells.  Calcif Tissue Int  2006  78(3):171-7  PubMed ID: 16523220   DOI: 10.1007/s00223-005-1233-y
6481  Reinhold MI, Kapadia RM, Liao Z, Naski MC.  The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis.  J Biol Chem  2006  281(3):1381-8  PubMed ID: 16293629   DOI: 10.1074/jbc.M504875200
6482  Kanda Y1, Hisayasu S, Fukai F, Takase B.  Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms.  Life Sci  2006  78(6):640-8  PubMed ID: 16111716   DOI: 10.1016/j.lfs.2005.05.081
6483  Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, Ikegawa S.  Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene.  Biochem Biophys Res Commun  2006  341(1):121-7  PubMed ID: 16413503   DOI: 10.1016/j.bbrc.2005.12.159
6484  Huitema LF, van Weeren PR, Barneveld A, van de Lest CH, Helms JB, Vaandrager AB.  Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.  Eur J Pharmacol  2006  542(1-3):48-53  PubMed ID: 16828741   DOI: 10.1016/j.ejphar.2006.06.006
6485  Stewart AJ, Houston B, Farquharson C.  Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.  J Cell Physiol  2006  206(2):435-40  PubMed ID: 16155924   DOI: 10.1002/jcp.20481
6486  Phornphutkul C, Wu KY, Gruppuso PA.  The role of insulin in chondrogenesis.  Mol Cell Endocrinol  2006  249(1-2):107-15  PubMed ID: 16530934   DOI: 10.1016/j.mce.2006.02.002
6487  Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y.  Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.  J Biol Chem  2006  281(33):23632-42  PubMed ID: 16777848   DOI: 10.1074/jbc.M512362200
6488  Chen L, Fink T, Ebbesen P, Zachar V.  Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions.  Tissue Eng  2006  12(3):559-67  PubMed ID: 16579689   DOI: 10.1089/ten.2006.12.559
6489  Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A.  TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.  Arthritis Res Ther  2006  8(5):R146  PubMed ID: 16945157   DOI: 10.1186/ar2038
6490  Fukui N, Ikeda Y, Ohnuki T, Hikita A, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.  Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.  J Biol Chem  2006  281(37):27229-41  PubMed ID: 16835229   DOI: 10.1074/jbc.M603385200
6491  MacRae VE, Farquharson C, Ahmed SF.  The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.  J Endocrinol  2006  189(2):319-28  PubMed ID: 16648299   DOI: 10.1677/joe.1.06609
6492  MacRae VE, Burdon T, Ahmed SF, Farquharson C.  Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.  J Endocrinol  2006  191(2):369-77  PubMed ID: 17088406   DOI: 10.1677/joe.1.06958
6976  Nagai N, Anzawa T, Satoh Y, Suzuki T, Tajima K, Munekata M.  Activities of MC3T3-E1 cells cultured on gamma-irradiated salmon atelocollagen scaffold.  J Biosci Bioeng  2006  101(6):511-4  PubMed ID: 16935254   DOI: 10.1263/jbb.101.511
2874  Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI  The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.  Biochem Biophys Res Commun  2005  333:1300-8  PubMed ID: 15979579   DOI: 10.1016/j.bbrc.2005.06.041
3120  Tamayama T, Maemura K, Kanbara K, Hayasaki H, Yabumoto Y, Yuasa M, Watanabe M.  Expression of GABA(A) and GABA(B) receptors in rat growth plate chondrocytes: activation of the GABA receptors promotes proliferation of mouse chondrogenic ATDC5 cells.  Mol. Cell. Biochem.  2005  273:117-26  PubMed ID: 16013446   DOI: 10.1007/s11010-005-8159-6
3194  Hinoi E, Wang L, Takemori A, Yoneda Y.  Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.  Biochem. Pharmacol.  2005  70:70-81  PubMed ID: 15894296   DOI: 10.1016/j.bcp.2005.04.025
5399  Takumi Tamayama, Kentaro Maemura, Kiyoto Kanbara,Hana Hayasaki, Yasuaki Yabumoto, Masayoshi Yuasa,and Masahito Watanabe  Expression of GABAAand GABABreceptorsin rat growth plate chondrocytes: Activationof the GABA receptors promotes proliferationof mouse chondrogenic ATDC5 cells  Molecular and Cellular Biochemistry  2005  273:117–126   
4989  Kirimoto A1, Takagi Y, Ohya K, Shimokawa H.  Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5.  J Med Dent Sci  2005  52(3):153-62  PubMed ID: 16350840  
5412  Chen L, Fink T, Zhang XY, Ebbesen P, Zachar V.  Quantitative transcriptional profiling of ATDC5 mouse progenitor cells during chondrogenesis.  Differentiation  2005  73(7):350-63  PubMed ID: 16219039   DOI: 10.1111/j.1432-0436.2005.00038.x
5972  Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R.  Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.  Biochem J  2005  389(Pt 2):315-23  PubMed ID: 15784009   DOI: 10.1042/BJ20041996
6221  Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.  Hum Mol Genet  2005  14(8):1009-17  PubMed ID: 15746150   DOI: 10.1093/hmg/ddi093
6230  Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H.  Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.  J Cell Physiol  2005  204(3):927-33  PubMed ID: 15795936   DOI: 10.1002/jcp.20350
6245  Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K.  Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.  Exp Cell Res  2005  310(2):256-69  PubMed ID: 16165127   DOI: 10.1016/j.yexcr.2005.07.025
4968  Okada A, Shiomi T, Aoki Y, Fujiwara M.  Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5.  J Toxicol Sci  2005  30(3):145-56  PubMed ID: 16141649   DOI: 10.2131/jts.30.145
6222  Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P.  GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton.  Bone  2005  37(2):139-47  PubMed ID: 15946906   DOI: 10.1016/j.bone.2005.04.015
6871  Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG.  Regulation of the human Sox9 promoter by the CCAAT-binding factor.  Matrix Biol   2005  24(3):185-97  PubMed ID: 15908194   DOI: 10.1016/j.matbio.2005.04.001
3158  Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio  Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.  Exp Cell Res  2004  295:119-27  PubMed ID: 15051495   DOI: 10.1016/j.yexcr.2003.12.018
2899  Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa  Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.  J Cell Biol  2004  166:85-95  PubMed ID: 15226309   DOI: 10.1083/jcb.200401138
2926  French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc  WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.  Am J Pathol  2004  165:855-67  PubMed ID: 15331410   DOI: 10.1016/S0002-9440(10)63348-2
2900  Nakajima M, Negishi Y, Tanaka H, Kawashima K.  p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.  Biochem. Biophys. Res. Commun.  2004  320:1069-75  PubMed ID: 15249198   DOI: 10.1016/j.bbrc.2004.06.057
3330  Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.  Molecular recognition of BMP-2 and BMP receptor IA.  Nat. Struct. Mol. Biol.  2004  11:481-8  PubMed ID: 15064755   DOI: 10.1038/nsmb756
6247  Fujita T, Fukuyama R, Enomoto H, Komori T.  Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.  J Cell Biochem  2004  93(2):374-83  PubMed ID: 15368363   DOI: 10.1002/jcb.20192
6294  Yamagiwa H, Yamada Y, Bolander ME, Sarkar G.  Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell.  Mol Biotechnol  2004  28(1):1-8  PubMed ID: 15456958   DOI: 10.1385/MB:28:1:01
6306  Madhavi Ayyalasomayajula , Sydha Salihu , Vincent Kish , Nilay Mukherjee  Influence of Rearrangement of Actin Cytoskeleton on the Overall Material Properties of ATDC5 Cells During Chondrogenesis  Advances in Bioengineering  2004  359-360    DOI: 10.1115/IMECE2004-61286
6345  Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F.  Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.  Biochem Biophys Res Commun  2004  315(2):272-80  PubMed ID: 14766204   DOI: 10.1016/j.bbrc.2004.01.048
6373  Yamagiwa H, Bolander ME, Sarkar G.  Evaluation of different conditions for ligating dumbbell-shaped oligonucleotides.  Mol Biotechnol  2004  26(2):111-6  PubMed ID: 14764936   DOI: 10.1385/MB:26:2:111
6375  Jayendran Srinivasan , Vincent Kish , Sydha Salihu , Madhavi Ayyalasomayajula , Nilay Mukherjee  Poking Cells in Cell-Gel Constructs: A Potential Way of Measuring Fluid Pressure in Cells  Advances in Bioengineering  2004  361-362    DOI: 10.1115/IMECE2004-61290
3591  Hidaka K, Kanematsu T, Caffrey JJ, Takeuchi H, Shears SB, Hirata M.  The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.  Exp Cell Res  2003  290(2):254-64  PubMed ID: 14567985   DOI: 10.1016/s0014-4827(03)00337-9
3549  Yamanaka Y, Tanaka H, Koike M, Nishimura R, Seino Y.  PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.  J Bone Miner Res  2003  18(8):1395-403  PubMed ID: 12929929   DOI: 10.1359/jbmr.2003.18.8.1395
4777  Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR, Kyung HM, Sung JH, Wozney JM, Kim HJ, Ryoo HM.  BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression.  J Biol Chem  2003  278(36):34387-94. Epub 2003 Jun 18  PubMed ID: 12815054   DOI: 10.1074/jbc.M211386200
4820  Watanabe N, Tezuka Y, Matsuno K, Miyatani S, Morimura N, Yasuda M, Fujimaki R, Kuroda K, Hiraki Y, Hozumi N, Tezuka K.  Suppression of differentiation and proliferation of early chondrogenic cells by Notch.  J Bone Miner Metab  2003  21(6):344-52  PubMed ID: 14586790   DOI: 10.1007/s00774-003-0428-4
4874  Nishiyama T, Hatano H, Kurosaka M, Bolander ME, Sarkar G.  Cis-acting intronic elements that regulate cartilage-specific alternative splicing of the type II collagen (Col2) pre-mRNA lie at or near splice site junction sequences flanking exon 2 of the gene.  J Bone Miner Res  2003  18(9):1716-22  PubMed ID: 12968682   DOI: 10.1359/jbmr.2003.18.9.1716
4908  Shinsuke Aoki et al  A new approach to an artificial joint based on bio-cartilage/porous β-tricalcium phosphate system  Journal of the European Ceramic Society  2003  23:2939-2946    DOI: 10.1016/S0955-2219(03)00305-4
4937  Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung UI, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H.  Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.  J Biol Chem  2003  278(48):48259-66  PubMed ID: 13679380   DOI: 10.1074/jbc.M211639200
4944  Oda R, Suardita K, Fujimoto K, Pan H, Yan W, Shimazu A, Shintani H, Kato Y.  Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.  J Cell Sci  2003  116(Pt 10):2029-38  PubMed ID: 12679380   DOI: 10.1242/jcs.00393
4978  Lee MH, Kwon TG, Park HS, Wozney JM, Ryoo HM.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.  Biochem Biophys Res Commun  2003  309(3):689-94  PubMed ID: 12963046   DOI: 10.1016/j.bbrc.2003.08.058
3555  Nishigaki F, Sakuma S, Ogawa T, Miyata S, Ohkubo T, Goto T.  FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5.  Eur J Pharmacol  2002  437(3):123-8  PubMed ID: 11890899   DOI: 10.1016/s0014-2999(02)01269-4
3556  Suda M, Tanaka K, Yasoda A, Komatsu Y, Chusho H, Miura M, Tamura N, Ogawa Y, Nakao K.  C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line.  J Bone Miner Metab  2002  20(3):136-41  PubMed ID: 11984695   DOI: 10.1007/s007740200019
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