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1371 Bertram, J S, Janik P Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture. Cancer Lett 1980 11:63-73 PubMed ID: 7226139 DOI: 10.1016/0304-3835(80)90130-5

4767 Janik P, Assaf A, Bertram JS. Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine. Cancer Res 1980 40(6):1950-4 PubMed ID: 6154533

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20693 Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K. D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy. Oncol Rep 2022 47(6) PubMed ID: 35543153 DOI: 10.3892/or.2022.8328

20730 Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J, Kawamoto H, Mandai M, Suzuki Y, Miura M, Bamba T, Izumi Y, Kawaoka S. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Nat Commun 2022 13(1):3346 PubMed ID: 35705545 DOI: 10.1038/s41467-022-30926-z

20055 Watanabe R, Esaki T, Ohashi R, Kuroda M, Kawashima H, Komura H, Natsume-Kitatani Y, Mizuguchi K. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration. J Med Chem 2021 PubMed ID: 33619967 DOI: 10.1021/acs.jmedchem.0c02011

20199 Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun 2021 12(1):3655 PubMed ID: 34135341 DOI: 10.1038/s41467-021-23969-1

20222 Hu L, Hayashi Y, Kidoya H, Takakura N. Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization. Sci Rep 2021 11(1):14047 PubMed ID: 34234274 DOI: 10.1038/s41598-021-93619-5

20235 Sun L, Morikawa K, Sogo Y, Sugiura Y. MHY1485 enhances X-irradiation-induced apoptosis and senescence in tumor cells. J Radiat Res 2021 PubMed ID: 34265852 DOI: 10.1093/jrr/rrab057

20284 Ieguchi K, Tomita T, Takao T, Omori T, Mishima T, Shimizu I, Tognolini M, Lodola A, Tsunoda T, Kobayashi S, Wada S, Maru Y. Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions. Int J Mol Sci 2021 22(5) PubMed ID: 33804570 DOI: 10.3390/ijms22052480

15493 KAZUMI YOSHIZAWA, RUKA KURONO, HARUKA SATO, ERIKA ISHIJIMA, HARUKA NASU, NURFARHANA FERDAOS, HIDETAKA SUZUKI and KENICHI NEGISHI ffect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose CANCER DIAGNOSIS & PROGNOSIS 2021 1:95-102 DOI: 10.21873/cdp.10014

13056 Yoshizawa K, Tabuchi M, Ukai S, Suzuki H, Kawano Y, Takasawa R. The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice. Anticancer Res 2020 PubMed ID: 32487622 DOI: 10.21873/anticanres.14309

4047 Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N. TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity Dev Cell 2019 48(2):151-166 PubMed ID: 30639056 DOI: 10.1016/j.devcel.2018.12.002

11311 Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M. Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment. Oncogene 2019 PubMed ID: 30459356 DOI: 10.1038/s41388-018-0564-x

11310 Wang Y, Zenkoh J, Gerelchuluun A, Sun L, Cai S, Li X, Tsuboi K. Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines. Int. J. Radiat. Oncol. Biol. Phys. 2019 PubMed ID: 30458232 DOI: 10.1016/j.ijrobp.2018.11.019

12503 Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K. Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma Cancer Sci 2019 110(10):3061-3067 PubMed ID: 31444833 DOI: 10.1111/cas.14179

10609 Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T. Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells. J. Pathol. 2018 244:84-96 PubMed ID: 29124765 DOI: 10.1002/path.4993

10811 Yamakawa D, Jia W, Kidoya H, Hosojima S, Torigata M, Zhang L, Takakura N. Visualization of Proliferative Vascular Endothelial Cells in Tumors in Vivo by Imaging Their Partner of Sld5-1 Promoter Activity. Am. J. Pathol. 2018 188:1300-1314 PubMed ID: 29650228 DOI: 10.1016/j.ajpath.2018.01.015

14825 Eino D, Tsukada Y, Naito H, Kanemura Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Arita H, Kagawa N, Fujimoto Y, Takara K, Kishima H, Takakura N. LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors Cancer Res 2018 78(23):6607-6620 PubMed ID: 30301839 DOI: 10.1158/0008-5472.CAN-18-0498

10663 Okuma A, Hanyu A, Watanabe S, Hara E. p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis. Nat Commun 2017 8:2050 PubMed ID: 29234059 DOI: 10.1038/s41467-017-02281-x

6349 Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, Magnone V, Rios G, Mari B, Barbry P. A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse. J Biol Chem. 2017 292(30):12483-12495 PubMed ID: 28596382 DOI: 10.1074/jbc.M117.776260

14214 Tanaka M, Kuriyama S, Itoh G, Maeda D, Goto A, Tamiya Y, Yanagihara K, Yashiro M, Aiba N. Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Cancer Res 2017 77(3):684-695 PubMed ID: 27895076 DOI: 10.1158/0008-5472.CAN-16-0964

14246 Kanzaki R, Naito H, Kise K, Takara K, Eino D, Minami M, Shintani Y, Funaki S, Kawamura T, Kimura T, Okumura M, Takakura N. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy Sci Rep 2017 7(1):10613 PubMed ID: 28878389 DOI: 10.1038/s41598-017-10873-2

14722 Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages Proc Natl Acad Sci U S A 2017 114(35):E7331-E7340 PubMed ID: 28808017 DOI: 10.1073/pnas.1708598114

14736 Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact Cell Rep 2017 20(9):2072-2086 PubMed ID: 28854359 DOI: 10.1016/j.celrep.2017.07.080

7088 Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R. PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep 2016 6:18979 PubMed ID: 26742562 DOI: 10.1038/srep18979

9613 Wang X, Li X, Yoshiyuki K, Watanabe Y, Sogo Y, Ohno T, Tsuji NM, Ito A. Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy. Adv Healthc Mater 2016 5:1169-76 PubMed ID: 26987867 DOI: 10.1002/adhm.201501013

9643 Naito H, Wakabayashi T, Kidoya H, Muramatsu F, Takara K, Eino D, Yamane K, Iba T, Takakura N. Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance. Cancer Res. 2016 76:3200-10 PubMed ID: 27197162 DOI: 10.1158/0008-5472.CAN-15-2998

9822 Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M. Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. Respir. Res. 2016 17:110 PubMed ID: 27596748 DOI: 10.1186/s12931-016-0427-3

9904 Hanaoka Y, Yamaguchi Y, Yamamoto H, Ishii M, Nagase T, Kurihara H, Akishita M, Ouchi Y. In Vitro and In Vivo Anticancer Activity of Human β-Defensin-3 and Its Mouse Homolog. Anticancer Res. 2016 36:5999-6004 PubMed ID: 27793926 DOI: 10.21873/anticanres.11188

5392 Tsutsumi K, Kaname T1, Shiraishi H1, Kawashiri T1, Egashira N. Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity. J Pharmacol Sci 2016 131(2):146-9 PubMed ID: 27262900 DOI: 10.1016/j.jphs.2016.04.019

14123 Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N. SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression Cancer Res 2016 76(2):358-69 PubMed ID: 26577701 DOI: 10.1158/0008-5472.CAN-15-1879

6338 Yu R, Zheng Y, Lucas MB, Tong YG. Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature. World J Gastrointest Pathophysiol 2015 6(4):131-9 PubMed ID: 26600971 DOI: 10.4291/wjgp.v6.i4.131

15134 Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M. Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice Sci Rep 2015 5:9083 PubMed ID: 25765541 DOI: 10.1038/srep09083

11037 Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T. PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo Cancer Immunol Res 2015 3(8):902-14 PubMed ID: 25898986 DOI: 10.1158/2326-6066.CIR-14-0219

15207 Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Takahashi H, Murakami M, Miyazaki A. Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells Circ Res 2015 116(7):1170-81 PubMed ID: 25648699 DOI: 10.1161/CIRCRESAHA.116.305363

15257 Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K. Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34 Oxid Med Cell Longev 2015 2015:170309 PubMed ID: 25821552 DOI: 10.1155/2015/170309

13661 Hasegawa H, Yamashita K, Otubo D, Fujii S, Kamigaki T, Kuroda D, Kakeji Y. Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation Anticancer Res 2014 34(7):3411-7. PubMed ID: 24982348

15295 Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K. Acrolein induced both pulmonary inflammation and the death of lung epithelial cells Toxicol Lett 2014 229(2):384-92 PubMed ID: 24999835 DOI: 10.1016/j.toxlet.2014.06.021

15795 Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A. Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy Sci Rep 2013 3:2203 PubMed ID: 23857555 DOI: 10.1038/srep02203

5377 Mizumoto S, Takahashi J, Sugahara K. Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells. J Biol Chem 2012 287(23):18985-94 PubMed ID: 22493510 DOI: 10.1074/jbc.M111.313437

7872 Hara K, Kasahara E, Takahashi N, Konishi M, Inoue J, Jikumaru M, Kubo S, Okamura H, Sato E, Inoue M. Mitochondria determine the efficacy of anticancer agents that interact with DNA but not the cytoskeleton. J. Pharmacol. Exp. Ther. 2011 337:838-45 PubMed ID: 21421738 DOI: 10.1124/jpet.111.179473

8218 Yin X, Yan X, Yang Q, Cao H, Liang H. Antitumor mechanism of recombinant murine interleukin-12 vaccine. Cancer Biother. Radiopharm. 2010 25:263-8 PubMed ID: 20578831 DOI: 10.1089/cbr.2010.0771

8326 Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E, Hata R. Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell transplants. [corrected] Transgenic Res. 2010 19:1109-17 PubMed ID: 20333465 DOI: 10.1007/s11248-010-9384-7

8438 Yin XL, Yan X, Wen M, Peng ZP, Li SL. Synergistic antitumor effects of 131I-LC-1 IgM and IL-12 vaccine on Lewis lung carcinoma. Int. Immunopharmacol. 2010 10:284-9 PubMed ID: 19951748 DOI: 10.1016/j.intimp.2009.11.012

5373 Kawashiri T, Egashira N, Itoh Y, Shimazoe T, Ikegami Y, Yano T, Yoshimura M, Oishi R. Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. Eur J Cancer 2009 45(1):154-63 PubMed ID: 19027286 DOI: 10.1016/j.ejca.2008.10.004

8763 Jung YK, Jin JS, Jeong JH, Kim HN, Park NR, Choi JY. DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin. J. Cell. Physiol. 2008 216:603-14 PubMed ID: 18366072 DOI: 10.1002/jcp.21438

8812 Yamamura H, Hirano N, Koyama H, Nishizawa Y, Takahashi K. Loss of smooth muscle calponin results in impaired blood vessel maturation in the tumor-host microenvironment. Cancer Sci. 2007 98:757-63 PubMed ID: 17391313 DOI: 10.1111/j.1349-7006.2007.00452.x

3567 Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M. Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor. In Vivo 2007 21(2):291-5 PubMed ID: 17436579

6293 Imai N, Hashimoto T, Kihara M, Yoshida S, Kawana I, Yazawa T, Kitamura H, Umemura S. Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis. Lab Invest 2007 87(2):189-98 PubMed ID: 17318197 DOI: 10.1038/labinvest.3700504

3290 Nakamura, Kazuki, Yoshikawa, Noriko, Yamaguchi, Yu, Kagota, Satomi, Shinozuka, Kazumasa, Kunitomo, Masaru Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res 2006 26:43-7 PubMed ID: 16475677

13654 Kushida S, Ohmae H, Kamma H, Totsuka R, Matsumura M, Takeuchi A, Saiki I, Yanagawa T, Onizawa K, Ishii T, Ohn T. Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with lewis lung carcinoma and B16 melanoma cells Int J Hyperthermia 2006 22(8):699-712 PubMed ID: 17390999 DOI: 10.1080/02656730601088508

16794 Jiang Jing Gao, Akiko Hirakawa, Byung Sun Min, Norio Nakamura, Masao Hattori In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum Journal of Natural Medicines 2006 60:42-48 DOI: 10.1007/s11418-005-0003-5

3336 Kuang M, Liu, S Q, Saijo K, Uchimura E, Huang L, Leong, K W, Lu, M D, Huang, J F, Ohno T Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity. Int J Hyperthermia 2005 21:247-57 PubMed ID: 16019851 DOI: 10.1080/02656730500052027

9035 Li-Quan Wang, Byung-Sun Min, Yan Li, Norio Nakamura, Guo-Wei Qin, Can-Jun Li, Masao Hattori Annonaceous Acetogenins From the Leaves of Annona Montana Bioorg Med Chem 2002 10 (3), 561-5 PubMed ID: 11814843 DOI: 10.1016/s0968-0896(01)00303-0

2636 Fujisawa H Inhibitory role of neutrophils on influenza virus multiplication in the lungs of mice. Microbiol Immunol 2001 45:679-88 PubMed ID: 11762750 DOI: 10.1111/j.1348-0421.2001.tb01302.x

16951 Kimura Y, Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice J Nutr 2001 131(6):1844-9 PubMed ID: 11385077 DOI: 10.1093/jn/131.6.1844

5370 Hamada K, Mikasa K, Yunou Y, Kurioka T, Majima T, Narita N, Kita E. Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer. Chemotherapy 2000 46(1):49-61 PubMed ID: 10601798 DOI: 10.1159/000007256

6266 Matsui H, Kimura A, Yamashiki N, Moriyama A, Kaya M, Yoshida I, Takagi N, Takahashi T. Molecular and biochemical characterization of a serine proteinase predominantly expressed in the medulla oblongata and cerebellar white matter of mouse brain. J Biol Chem 2000 275(15):11050-7 PubMed ID: 10753908 DOI: 10.1074/jbc.275.15.11050

1904 Min BS, Gao JJ, Nakamura N, Hattori M. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells Chem Pharm Bull (Tokyo) 2000 48(7):1026-33 PubMed ID: 10923835 DOI: 10.1248/cpb.48.1026

2355 Nakamura K, Yamaguchi Y, Kagota S, Kwon, Y M, Shinozuka K, Kunitomo M Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J Pharmacol 1999 79:335-41 PubMed ID: 10230862 DOI: 10.1254/jjp.79.335

2270 Sumimoto H, Tani K, Nakazaki Y, Tanabe T, Hibino H, Wu, M S, Izawa K, Hamada H, Asano S Superiority of interleukin-12 taransduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice Cancer Gene Therapy 1998 5:29-37 PubMed ID: 9476964

3952 Akatsu T, Ono K, Katayama Y, Tamura T, Nishikawa M, Kugai N, Yamamoto M, Nagata N. The mouse mammary tumor cell line, MMT060562, produces prostaglandin E2 and leukemia inhibitory factor and supports osteoclast formation in vitro via a stromal cell-dependent pathway. J Bone Miner Res 1998 13(3):400-8 PubMed ID: 9525340 DOI: 10.1359/jbmr.1998.13.3.400

6261 Matsui H, Ohnishi J, Takahashi T. Proteolytic activation of tissue-type plasminogen activator by the culture media of mouse cancer cells. Zoolog Sci 1998 15(4):499-505 PubMed ID: 18462028 DOI: 10.2108/0289-0003(1998)15[499:PAOTPA]2.0.CO;2

16751 Hasegawa H, Uchiyama M. Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite Planta Med 1998 64(8):696-700 PubMed ID: 9933987 DOI: 10.1055/s-2006-957560

2199 Sumimoto H, Tani K, Nakazaki Y, Tanabe T, Hibino H, Hamada H, Azuma M, Asano S GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice. Int J Cancer 1997 73:556-61 PubMed ID: 9389572 DOI: 10.1002/(sici)1097-0215(19971114)73:4<556::aid-ijc17>3.0.co;2-7