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Cell No. : Cell Name
RCB0558 : LLC  update : 2023/08/22
CommentHighly metastatic and drug-resistant mouse tumor. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Sugimoto, Yoshikazu
Originator Sugimoto, Y. (in vitro)
Year of deposit 1990
Another name Lewis lung carcinoma
Animal _mouse < Mammals
Tissue lung
Metastastatic ability Yes
Classification cancer
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_4358
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-6 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 2
User's Publication 69

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1371  Bertram, J S, Janik P  Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture.  Cancer Lett  1980  11:63-73  PubMed ID: 7226139   DOI: 10.1016/0304-3835(80)90130-5
4767  Janik P, Assaf A, Bertram JS.  Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine.  Cancer Res  1980  40(6):1950-4  PubMed ID: 6154533  

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User's Publication
21087  Shimizu T, Matsuzaki T, Fukuda S, Yoshioka C, Shimazaki Y, Takese S, Yamanaka K, Nakae T, Ishibashi M, Hamamoto H, Ando H, Ishima Y, Ishida T.  Ionic Liquid-Based Transcutaneous Peptide Antitumor Vaccine: Therapeutic Effect in a Mouse Tumor Model.  AAPS J  2023  25(2):27  PubMed ID: 36805860   DOI: 10.1208/s12248-023-00790-w
21315  Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing JB, Sakaguchi S, Yamamoto M.  A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.  Cell Rep  2023  42(7):112813  PubMed ID: 37440410   DOI: 10.1016/j.celrep.2023.112813
21378  Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S.  Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.  Nat Commun  2023  14(1):4960  PubMed ID: 37620307   DOI: 10.1038/s41467-023-40371-1
17499  Bishoy El-Aarag, Evet El-Tahan, Magdy Zahran  New Thalidomide Derivative with An Anti-Migrative and Anti-Proliferative Effects on Lewis Lung Carcinoma Cell  Egyptian Journal of Chemistry  2022      DOI: 10.21608/ejchem.2022.109507.4997
18101  Sugimoto C, Murakami Y, Ishii E, Fujita H, Wakao H.  Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity  Elife  2022  11:e70848  PubMed ID: 35379387   DOI: 10.7554/eLife.70848
20693  Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K.  D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy.  Oncol Rep  2022  47(6)  PubMed ID: 35543153   DOI: 10.3892/or.2022.8328
20730  Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J, Kawamoto H, Mandai M, Suzuki Y, Miura M, Bamba T, Izumi Y, Kawaoka S.  Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.  Nat Commun  2022  13(1):3346  PubMed ID: 35705545   DOI: 10.1038/s41467-022-30926-z
20055  Watanabe R, Esaki T, Ohashi R, Kuroda M, Kawashima H, Komura H, Natsume-Kitatani Y, Mizuguchi K.  Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration.  J Med Chem  2021    PubMed ID: 33619967   DOI: 10.1021/acs.jmedchem.0c02011
20199  Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S.  Extracellular mRNA transported to the nucleus exerts translation-independent function.  Nat Commun  2021  12(1):3655  PubMed ID: 34135341   DOI: 10.1038/s41467-021-23969-1
20222  Hu L, Hayashi Y, Kidoya H, Takakura N.  Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization.  Sci Rep  2021  11(1):14047  PubMed ID: 34234274   DOI: 10.1038/s41598-021-93619-5
20235  Sun L, Morikawa K, Sogo Y, Sugiura Y.  MHY1485 enhances X-irradiation-induced apoptosis and senescence in tumor cells.  J Radiat Res  2021    PubMed ID: 34265852   DOI: 10.1093/jrr/rrab057
20284  Ieguchi K, Tomita T, Takao T, Omori T, Mishima T, Shimizu I, Tognolini M, Lodola A, Tsunoda T, Kobayashi S, Wada S, Maru Y.  Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions.  Int J Mol Sci  2021  22(5)  PubMed ID: 33804570   DOI: 10.3390/ijms22052480
15493  Yoshizawa K, Kurono R, Sato H, Ishijima E, Nasu H, Ferdaos N, Suzuki H, Negishi K.  Effect of Sucrose on Cisplatin-induced Fatigue-like Behavior in Mice: Comparison With Fructose and Glucose  Cancer Diagn Progn  2021  1:95-102  PubMed ID: 35403134   DOI: 10.21873/cdp.10014
13056  Yoshizawa K, Tabuchi M, Ukai S, Suzuki H, Kawano Y, Takasawa R.  The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.  Anticancer Res  2020    PubMed ID: 32487622   DOI: 10.21873/anticanres.14309
4047  Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.  TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity  Dev Cell  2019  48(2):151-166  PubMed ID: 30639056   DOI: 10.1016/j.devcel.2018.12.002
11311  Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M.  Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment.  Oncogene  2019    PubMed ID: 30459356   DOI: 10.1038/s41388-018-0564-x
11310  Wang Y, Zenkoh J, Gerelchuluun A, Sun L, Cai S, Li X, Tsuboi K.  Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines.  Int. J. Radiat. Oncol. Biol. Phys.  2019    PubMed ID: 30458232   DOI: 10.1016/j.ijrobp.2018.11.019
12503  Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K.  Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma  Cancer Sci  2019  110(10):3061-3067  PubMed ID: 31444833   DOI: 10.1111/cas.14179
10609  Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T.  Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells.  J. Pathol.  2018  244:84-96  PubMed ID: 29124765   DOI: 10.1002/path.4993
10811  Yamakawa D, Jia W, Kidoya H, Hosojima S, Torigata M, Zhang L, Takakura N.  Visualization of Proliferative Vascular Endothelial Cells in Tumors in Vivo by Imaging Their Partner of Sld5-1 Promoter Activity.  Am. J. Pathol.  2018  188:1300-1314  PubMed ID: 29650228   DOI: 10.1016/j.ajpath.2018.01.015
14825  Eino D, Tsukada Y, Naito H, Kanemura Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Arita H, Kagawa N, Fujimoto Y, Takara K, Kishima H, Takakura N.  LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors  Cancer Res  2018  78(23):6607-6620  PubMed ID: 30301839   DOI: 10.1158/0008-5472.CAN-18-0498
10663  Okuma A, Hanyu A, Watanabe S, Hara E.  p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.  Nat Commun  2017  8:2050  PubMed ID: 29234059   DOI: 10.1038/s41467-017-02281-x
6349  Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, Magnone V, Rios G, Mari B, Barbry P.  A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse.  J Biol Chem.   2017  292(30):12483-12495  PubMed ID: 28596382   DOI: 10.1074/jbc.M117.776260
14214  Tanaka M, Kuriyama S, Itoh G, Maeda D, Goto A, Tamiya Y, Yanagihara K, Yashiro M, Aiba N.  Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion  Cancer Res  2017  77(3):684-695  PubMed ID: 27895076   DOI: 10.1158/0008-5472.CAN-16-0964
14246  Kanzaki R, Naito H, Kise K, Takara K, Eino D, Minami M, Shintani Y, Funaki S, Kawamura T, Kimura T, Okumura M, Takakura N.  Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy  Sci Rep  2017  7(1):10613  PubMed ID: 28878389   DOI: 10.1038/s41598-017-10873-2
14722  Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.  Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages  Proc Natl Acad Sci U S A  2017  114(35):E7331-E7340  PubMed ID: 28808017   DOI: 10.1073/pnas.1708598114
14736  Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N.  Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact  Cell Rep  2017  20(9):2072-2086  PubMed ID: 28854359   DOI: 10.1016/j.celrep.2017.07.080
7088  Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R.  PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.  Sci Rep  2016  6:18979  PubMed ID: 26742562   DOI: 10.1038/srep18979
9613  Wang X, Li X, Yoshiyuki K, Watanabe Y, Sogo Y, Ohno T, Tsuji NM, Ito A.  Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy.  Adv Healthc Mater  2016  5:1169-76  PubMed ID: 26987867   DOI: 10.1002/adhm.201501013
9643  Naito H, Wakabayashi T, Kidoya H, Muramatsu F, Takara K, Eino D, Yamane K, Iba T, Takakura N.  Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance.  Cancer Res.  2016  76:3200-10  PubMed ID: 27197162   DOI: 10.1158/0008-5472.CAN-15-2998
9822  Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, Kobayashi S, Yanai M, Shimura S, Ochiya T, Ichinose M.  Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis.  Respir. Res.  2016  17:110  PubMed ID: 27596748   DOI: 10.1186/s12931-016-0427-3
9904  Hanaoka Y, Yamaguchi Y, Yamamoto H, Ishii M, Nagase T, Kurihara H, Akishita M, Ouchi Y.  In Vitro and In Vivo Anticancer Activity of Human β-Defensin-3 and Its Mouse Homolog.  Anticancer Res.  2016  36:5999-6004  PubMed ID: 27793926   DOI: 10.21873/anticanres.11188
5392  Tsutsumi K, Kaname T1, Shiraishi H1, Kawashiri T1, Egashira N.  Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity.  J Pharmacol Sci  2016  131(2):146-9  PubMed ID: 27262900   DOI: 10.1016/j.jphs.2016.04.019
14123  Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N.  SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression  Cancer Res  2016  76(2):358-69  PubMed ID: 26577701   DOI: 10.1158/0008-5472.CAN-15-1879
6338  Yu R, Zheng Y, Lucas MB, Tong YG.  Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature.  World J Gastrointest Pathophysiol  2015  6(4):131-9  PubMed ID: 26600971   DOI: 10.4291/wjgp.v6.i4.131
15134  Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M.  Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice  Sci Rep  2015  5:9083  PubMed ID: 25765541   DOI: 10.1038/srep09083
11037  Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T.  PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo  Cancer Immunol Res  2015  3(8):902-14  PubMed ID: 25898986   DOI: 10.1158/2326-6066.CIR-14-0219
15207  Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Takahashi H, Murakami M, Miyazaki A.  Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells  Circ Res  2015  116(7):1170-81  PubMed ID: 25648699   DOI: 10.1161/CIRCRESAHA.116.305363
15257  Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K.  Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34  Oxid Med Cell Longev  2015  2015:170309  PubMed ID: 25821552   DOI: 10.1155/2015/170309
13661  Hasegawa H, Yamashita K, Otubo D, Fujii S, Kamigaki T, Kuroda D, Kakeji Y.  Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation  Anticancer Res  2014  34(7):3411-7.  PubMed ID: 24982348  
15295  Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K.  Acrolein induced both pulmonary inflammation and the death of lung epithelial cells  Toxicol Lett  2014  229(2):384-92  PubMed ID: 24999835   DOI: 10.1016/j.toxlet.2014.06.021
15795  Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A.  Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy  Sci Rep  2013  3:2203  PubMed ID: 23857555   DOI: 10.1038/srep02203
5377  Mizumoto S, Takahashi J, Sugahara K.  Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells.  J Biol Chem  2012  287(23):18985-94  PubMed ID: 22493510   DOI: 10.1074/jbc.M111.313437
7872  Hara K, Kasahara E, Takahashi N, Konishi M, Inoue J, Jikumaru M, Kubo S, Okamura H, Sato E, Inoue M.  Mitochondria determine the efficacy of anticancer agents that interact with DNA but not the cytoskeleton.  J. Pharmacol. Exp. Ther.  2011  337:838-45  PubMed ID: 21421738   DOI: 10.1124/jpet.111.179473
8218  Yin X, Yan X, Yang Q, Cao H, Liang H.  Antitumor mechanism of recombinant murine interleukin-12 vaccine.  Cancer Biother. Radiopharm.  2010  25:263-8  PubMed ID: 20578831   DOI: 10.1089/cbr.2010.0771
8326  Izukuri K, Suzuki K, Yajima N, Ozawa S, Ito S, Kubota E, Hata R.  Chemokine CXCL14/BRAK transgenic mice suppress growth of carcinoma cell transplants. [corrected]  Transgenic Res.  2010  19:1109-17  PubMed ID: 20333465   DOI: 10.1007/s11248-010-9384-7
8438  Yin XL, Yan X, Wen M, Peng ZP, Li SL.  Synergistic antitumor effects of 131I-LC-1 IgM and IL-12 vaccine on Lewis lung carcinoma.  Int. Immunopharmacol.  2010  10:284-9  PubMed ID: 19951748   DOI: 10.1016/j.intimp.2009.11.012
5373  Kawashiri T, Egashira N, Itoh Y, Shimazoe T, Ikegami Y, Yano T, Yoshimura M, Oishi R.  Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy.  Eur J Cancer  2009  45(1):154-63  PubMed ID: 19027286   DOI: 10.1016/j.ejca.2008.10.004
8763  Jung YK, Jin JS, Jeong JH, Kim HN, Park NR, Choi JY.  DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin.  J. Cell. Physiol.  2008  216:603-14  PubMed ID: 18366072   DOI: 10.1002/jcp.21438
8812  Yamamura H, Hirano N, Koyama H, Nishizawa Y, Takahashi K.  Loss of smooth muscle calponin results in impaired blood vessel maturation in the tumor-host microenvironment.  Cancer Sci.  2007  98:757-63  PubMed ID: 17391313   DOI: 10.1111/j.1349-7006.2007.00452.x
3567  Yoshikawa N, Nakamura K, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M.  Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor.  In Vivo  2007  21(2):291-5  PubMed ID: 17436579  
6293  Imai N, Hashimoto T, Kihara M, Yoshida S, Kawana I, Yazawa T, Kitamura H, Umemura S.  Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.  Lab Invest  2007  87(2):189-98  PubMed ID: 17318197   DOI: 10.1038/labinvest.3700504
3290  Nakamura, Kazuki, Yoshikawa, Noriko, Yamaguchi, Yu, Kagota, Satomi, Shinozuka, Kazumasa, Kunitomo, Masaru  Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation.  Anticancer Res  2006  26:43-7  PubMed ID: 16475677  
13654  Kushida S, Ohmae H, Kamma H, Totsuka R, Matsumura M, Takeuchi A, Saiki I, Yanagawa T, Onizawa K, Ishii T, Ohn T.  Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with lewis lung carcinoma and B16 melanoma cells  Int J Hyperthermia  2006  22(8):699-712  PubMed ID: 17390999   DOI: 10.1080/02656730601088508
16794  Jiang Jing Gao, Akiko Hirakawa, Byung Sun Min, Norio Nakamura, Masao Hattori  In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum  Journal of Natural Medicines  2006  60:42-48    DOI: 10.1007/s11418-005-0003-5
3336  Kuang M, Liu, S Q, Saijo K, Uchimura E, Huang L, Leong, K W, Lu, M D, Huang, J F, Ohno T  Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.  Int J Hyperthermia  2005  21:247-57  PubMed ID: 16019851   DOI: 10.1080/02656730500052027
9035  Li-Quan Wang, Byung-Sun Min, Yan Li, Norio Nakamura, Guo-Wei Qin, Can-Jun Li, Masao Hattori  Annonaceous Acetogenins From the Leaves of Annona Montana  Bioorg Med Chem  2002  10 (3), 561-5  PubMed ID: 11814843   DOI: 10.1016/s0968-0896(01)00303-0
2636  Fujisawa H  Inhibitory role of neutrophils on influenza virus multiplication in the lungs of mice.  Microbiol Immunol  2001  45:679-88  PubMed ID: 11762750   DOI: 10.1111/j.1348-0421.2001.tb01302.x
16951  Kimura Y, Okuda H.  Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice  J Nutr  2001  131(6):1844-9  PubMed ID: 11385077   DOI: 10.1093/jn/131.6.1844
5370  Hamada K, Mikasa K, Yunou Y, Kurioka T, Majima T, Narita N, Kita E.  Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer.  Chemotherapy  2000  46(1):49-61  PubMed ID: 10601798   DOI: 10.1159/000007256
6266  Matsui H, Kimura A, Yamashiki N, Moriyama A, Kaya M, Yoshida I, Takagi N, Takahashi T.  Molecular and biochemical characterization of a serine proteinase predominantly expressed in the medulla oblongata and cerebellar white matter of mouse brain.  J Biol Chem  2000  275(15):11050-7  PubMed ID: 10753908   DOI: 10.1074/jbc.275.15.11050
1904  Min BS, Gao JJ, Nakamura N, Hattori M.  Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells  Chem Pharm Bull (Tokyo)   2000  48(7):1026-33  PubMed ID: 10923835   DOI: 10.1248/cpb.48.1026
2355  Nakamura K, Yamaguchi Y, Kagota S, Kwon, Y M, Shinozuka K, Kunitomo M  Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice.  Jpn J Pharmacol  1999  79:335-41  PubMed ID: 10230862   DOI: 10.1254/jjp.79.335
2270  Sumimoto H, Tani K, Nakazaki Y, Tanabe T, Hibino H, Wu, M S, Izawa K, Hamada H, Asano S  Superiority of interleukin-12 taransduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice  Cancer Gene Therapy  1998  5:29-37  PubMed ID: 9476964  
3952  Akatsu T, Ono K, Katayama Y, Tamura T, Nishikawa M, Kugai N, Yamamoto M, Nagata N.  The mouse mammary tumor cell line, MMT060562, produces prostaglandin E2 and leukemia inhibitory factor and supports osteoclast formation in vitro via a stromal cell-dependent pathway.  J Bone Miner Res  1998  13(3):400-8  PubMed ID: 9525340   DOI: 10.1359/jbmr.1998.13.3.400
6261  Matsui H, Ohnishi J, Takahashi T.  Proteolytic activation of tissue-type plasminogen activator by the culture media of mouse cancer cells.  Zoolog Sci  1998  15(4):499-505  PubMed ID: 18462028   DOI: 10.2108/0289-0003(1998)15[499:PAOTPA]2.0.CO;2
16751  Hasegawa H, Uchiyama M.  Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite  Planta Med  1998  64(8):696-700  PubMed ID: 9933987   DOI: 10.1055/s-2006-957560
2199  Sumimoto H, Tani K, Nakazaki Y, Tanabe T, Hibino H, Hamada H, Azuma M, Asano S  GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice.  Int J Cancer  1997  73:556-61  PubMed ID: 9389572   DOI: 10.1002/(sici)1097-0215(19971114)73:4<556::aid-ijc17>;2-7
18060  Hasegawa H, Sung JH, Huh JH.  Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent  Arch Pharm Res  1997  20(6):539-44  PubMed ID: 18982256   DOI: 10.1007/BF02975208

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