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Int J Mol Sci
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Tomohiro Itoh, Kanako Fukatani, Ayaka Nakashima, Kengo Suzuki
MicroRNA-141-3p and microRNA-200a-3p Regulate α-Melanocyte Stimulating Hormone-Stimulated Melanogenesis by Directly Targeting Microphthalmia-Associated Transcription Factor
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Biomedical Dermatology
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J Nat Med
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The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells
Int J Mol Sci
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Total Synthesis of γ-Alkylidenebutenolides, Potent Melanogenesis Inhibitors from Thai Medicinal Plant Melodorum fruticosum
J Org Chem
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J Cosmet Dermatol
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Int J Mol Sci
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Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus
Natural Product Communications
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Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells
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Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.
J Nat Med
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Phytomedicine
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Bioorg Med Chem
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Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity
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Deep Ocean Water Research
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Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna)
Bioorg Med Chem Lett
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Hideko MOTOJIMA, Myra O. VILLAREAL, Sayuri KUME, Konomi MURAKAMI, Hanen NAJJA, Mohamed NEFFATI, Hiroko ISODA
Anti-allergy and Melanogenesis Regulatory Effects of Semi-arid and Arid Land Plants
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2015
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Total Synthesis of 4,5-Didehydroguadiscine: A Potent Melanogenesis Inhibitor from the Brazilian Medicinal Herb, Hornschuchia obliqua
J Nat Prod
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78(7):1536-42
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Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays
J Applied Pharmaceutical Science
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Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers
J Dermatol Sci
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Ono K, Fujiwara T, Saito K, Nishizawa H, Takahashi N, Suzuki C, Ochi T, Kato H, Ishii Y, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Yamada R, Nakamura Y, Igarashi K, Harigae H.
Cytotoxic and melanogenesis-inhibitory activities of limonoids from the leaves of Azadirachta indica (Neem)
Chem Biodivers
2014
11(3):451-68
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Matsumoto T, Nakamura S, Nakashima S, Fujimoto K, Yoshikawa M, Ohta T, Ogawa K, Matsuda H.
Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis
J Nat Prod
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Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori Kumazawa
Anti-melanogenic compounds in Rubus croceacanthus
Journal of Berry Research
2014
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Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T.
Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities
Chem Biodivers
2014
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Shuuichi Akazaki, Toshie Takahashi, Yujiro Nakano, Tomoki Nishida, Hirotarou Mori, Akio Takaoka, Hitomi Aoki, Huayua Chen, Takahiro Kunisada, Kenzo Koike
Three-Dimensional Analysis of Melanosomes Isolated from B16 Melanoma Cells by Using Ultra High Voltage Electron Microscopy
Microscopy Research
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Zhang J, Koike R, Yamamoto A, Ukiya M, Fukatsu M, Banno N, Miura M, Motohashi S, Tokuda H, Akihisa T.
Glycosidic inhibitors of melanogenesis from leaves of Passiflora edulis
Chem Biodivers
2013
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Chao HC, Najjaa H, Villareal MO, Ksouri R, Han J, Neffati M, Isoda H.
Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells
Exp Dermatol
2013
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Akihisa T, Orido M, Akazawa H, Takahashi A, Yamamoto A, Ogihara E, Fukatsu M.
Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum
Chem Biodivers
2013
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Kikuchi T, Okada R, Harada Y, Ikushima K, Yamakawa T, Yamada T, Tanaka R.
Cucurbitane-type triterpenes from Citrullus lanatus (watermelon) seeds
Nat Prod Commun
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Kikuchi T, Takebayashi M, Shinto M, Yamada T, Tanaka R.
Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds
Molecules
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A novel 3α-p-Nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate and two new triterpenoids from the seeds of zucchini (Cucurbita pepo L)
Molecules
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Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.
Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
Bioorg Med Chem
2013
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Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Cell Struct Funct
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Zhang J, Nishimoto Y, Tokuda H, Suzuki N, Yasukawa K, Kitdamrongtham W, Akazawa H, Manosroi A, Manosroi J, Akihisa T.
Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood
Chem Biodivers
2013
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Nakamura S, Fujimoto K, Matsumoto T, Nakashima S, Ohta T, Ogawa K, Matsuda H, Yoshikawa M.
Acylated sucroses and acylated quinic acids analogs from the flower buds of Prunus mume and their inhibitory effect on melanogenesis
Phytochemistry
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92:128-36
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Akihisa T, Takeda A, Akazawa H, Kikuchi T, Yokokawa S, Ukiya M, Fukatsu M, Watanabe K.
Melanogenesis-inhibitory and cytotoxic activities of diarylheptanoids from Acer nikoense bark and their derivatives
Chem Biodivers
2012
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Kikuchi T, Watanabe K, Tochigi Y, Yamamoto A, Fukatsu M, Ezaki Y, Tanaka R, Akihisa T.
Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells
Chem Biodivers
2012
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Kikuchi T, Zhang J, Huang Y, Watanabe K, Ishii K, Yamamoto A, Fukatsu M, Tanaka R, Akihisa T.
Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia
Chem Biodivers
2012
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Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus
Chem Biodivers
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Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M.
Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis
Chem Pharm Bull (Tokyo)
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Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica
Chem Pharm Bull (Tokyo)
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Chem Biodivers
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Oral administration of immunopotentiator from Pantoea agglomerans 1 (IP-PA1) improves the survival of B16 melanoma-inoculated model mice
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Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells
Bioorg Med Chem
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Brazilian natural medicines. IV. New noroleanane-type triterpene and ecdysterone-type sterol glycosides and melanogenesis inhibitors from the roots of Pfaffia glomerata
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J Nat Med
2009
63:468-72
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Ohguchi K, Ito M, Yokoyama K, Iinuma M, Itoh T, Nozawa Y, Akao Y.
Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells.
Biol. Pharm. Bull.
2009
32:308-10
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18803
Matsuda H, Nakashima S, Oda Y, Nakamura S, Yoshikawa M.
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells
Bioorg Med Chem
2009
17(16):6048-53
PubMed ID: 19615910
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18812
Fujii T, Saito M.
Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells
Biosci Biotechnol Biochem
2009
73(9):1989-93
PubMed ID: 19734679
DOI: 10.1271/bbb.90181
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19277
Yamaoka Y, Ohguchi K, Itoh T, Nozawa Y, Akao Y.
Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells
Biosci Biotechnol Biochem
2009
73(6):1429-31
PubMed ID: 19502752
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8715
Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.
Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.
J. Agric. Food Chem.
2008
56:10515-20
PubMed ID: 18959405
DOI: 10.1021/jf8020877
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18680
Hanamura T, Uchida E, Aoki H.
Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation
Biosci Biotechnol Biochem
2008
72(12):3211-8
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19282
Ohguchi K, Koike M, Suwa Y, Koshimizu S, Mizutani Y, Nozawa Y, Akao Y.
Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells
Biosci Biotechnol Biochem
2008
72(4):1107-10
PubMed ID: 18391453
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18804
Kawano M, Matsuyama K, Miyamae Y, Shinmoto H, Kchouk ME, Morio T, Shigemori H, Isoda H.
Antimelanogenesis effect of Tunisian herb Thymelaea hirsuta extract on B16 murine melanoma cells
Exp Dermatol
2007
16(12):977-84
PubMed ID: 18031456
DOI: 10.1111/j.1600-0625.2007.00618.x
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6287
Roy MK, Kobori M, Takenaka M, Nakahara K, Shinmoto H, Isobe S, Tsushida T.
Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).
Phytother Res
2007
21(3):245-50
PubMed ID: 17163581
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15556
Kuniyoshi Shimizu, Shoko Fukunaga, Keisuke Yoshikawa, Ryuichiro Kondo
Screening of extracts of Japanese woods for melanin biosynthesis inhibition
Journal of Wood Science
2007
53:153-160
DOI: 10.1007/s10086-006-0824-1
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3313
Shoji, Toshihiko, Masumoto, Saeko, Moriichi, Nina, Kobori, Masuko, Kanda, Tomomasa, Shinmoto, Hiroshi, Tsushida, Tojiro
Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.
J Agric Food Chem
2005
53:6105-11
PubMed ID: 16029003
DOI: 10.1021/jf050418m
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17362
Enos Tangke Arung, Keisuke Yoshikawa, Kuniyoshi Shimizu, Ryuichiro Kondo
The effect of chlorophorin and its derivative on melanin biosynthesis
Holzforschung
2005
59:514-518
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2846
Fukui M, Nakano-Hashimoto T, Okano K, Maruta Y, Suehiro Y, Hamanaka Y, Yamashita H, Imai K, Kawano MM, Hinoda Y
Therapeutic effect of dendritic cells loaded with a fusion mRNA encoding tyrosinase-related protein 2 and enhanced green fluorescence protein on B16 melanoma.
Tumour Biol
2004
25:252-7
PubMed ID: 15627888
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3221
Ohguchi, Kenji, Banno, Yoshiko, Akao, Yukihiro, Nozawa, Yoshinori
Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.
J Biol Chem
2004
279:3408-12
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13484
Ohara M, Kobayashi M, Fujiwara H, Kitajima S, Mitsuoka C, Watanabe H.
Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea-pigs
Photodermatol Photoimmunol Photomed
2004
20(2):86-92
PubMed ID: 15030593
DOI: 10.1111/j.1600-0781.2004.00077.x
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13675
Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake, Ryuichiro Kondo, Mototake Tsutsui, Ikuo Sato
Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185
Journal of Wood Science
2003
49:349-354
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14423
Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T.
Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
Cancer Sci
2003
94(3):308-13
PubMed ID: 12824927
DOI: 10.1111/j.1349-7006.2003.tb01438.x
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17302
Masuko KOBORI
In Vitro-Screening for Cancer-Suppressive Effect of Food Components
Japan Agricultural Research Quarterly: JARQ
2003
37:159-165
DOI: 10.6090/jarq.37.159
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17287
X Zhao, T Sudo, Y Wakamatsu, M Shibahara, T Nakahara, T Murata, K Yokoyama
Mannosylerythritol Lipid Induced Apoptosis and Differentiation of Melanoma B16 Cells
Animal Cell Technology: Challenges for the 21st Century
2002
427-431
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6185
Matsui H, Takahashi T.
Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.
Endocrinology
2001
142(11):4918-29
PubMed ID: 11606460
DOI: 10.1210/endo.142.11.8505
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14426
Noguchi M, Imaizumi K, Kawabe T, Wakayama H, Horio Y, Sekido Y, Hara T, Hashimoto N, Takahashi M, Shimokata K, Hasegawa Y.
Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer
Cancer Gene Ther
2001
8(6):421-9
PubMed ID: 11498762
DOI: 10.1038/sj.cgt.7700320
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16943
Yasuto SASAKI, Midori KINOSHITA
Antioxidative and Antimelanogenetic Activities of a Water-Soluble Extract from Wheat Bran
Journal of Home Economics of Japan
2001
52:1171-1178
DOI: 10.11428/jhej1987.52.1171
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5066
Iwashita K, Kobori M, Yamaki K, Tsushida T.
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells.
Biosci Biotechnol Biochem
2000
64(9):1813-20
PubMed ID: 11055382
DOI: 10.1271/bbb.64.1813
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16532
Hirota A, Taki S, Kawaii S, Yano M, Abe N.
1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines
Biosci Biotechnol Biochem
2000
64(5):1038-40
PubMed ID: 10879475
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2368
Imaizumi K, Kawabe T, Ichiyama S, Kikutani H, Yagita H, Shimokata K, Hasegawa Y
Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction
Am J Physiol
1999
277(1 Pt 1):L49-57
PubMed ID: 10409230
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5065
Kobori M, Iwashita K, Shinmoto H, Tsushida T.
Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells.
Biosci Biotechnol Biochem
1999
63(4):719-25
PubMed ID: 10361685
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3525
Zhao X1, Wakamatsu Y, Shibahara M, Nomura N, Geltinger C, Nakahara T, Murata T, Yokoyama KK.
Mannosylerythritol lipid is a potent inducer of apoptosis and differentiation of mouse melanoma cells in culture.
Cancer Res
1999
59(2):482-6
PubMed ID: 9927066
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17250
X X Zhao, H Isoda, T Murata, K Yokoyama
Mannosylerythritol Lipid Induces Anti-Proliferation and Differentiation of Mouse Melanoma B16 Cells
Animal Cell Technology: Basic & Applied Aspects
1999
335-339
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2747
Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M, Takemura Y, Ju-ichi M, Ito C, Furukawa H.
The antiproliferative effect of acridone alkaloids on several cancer cell lines
J Nat Prod
1999
62(4):587-9
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15570
Keiko IWASHITA, Masuko KOBORI, Hiroshi SHINMOTO, Tojiro TSUSHIDA
Eggplant Extract Inhibits Melanogenesis in B16 Melanoma Cells.
Food Science and Technology International, Tokyo
1998
4:159-163
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18035
Sakurai T, Yamada M, Simamura S, Motoyoshi K.
Antimetastatic effect of recombinant human macrophage-colony-stimulating factor against lung and liver metastatic B16 melanoma
Cancer Immunol Immunother
1997
44(1):48-54
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18048
Hoq MM, Suzutani T, Toyoda T, Horiike G, Yoshida I, Azuma M.
Role of gamma delta TCR+ lymphocytes in the augmented resistance of trehalose 6,6'-dimycolate-treated mice to influenza virus infection
J Gen Virol
1997
78 ( Pt 7):1597-603
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18058
Shoji T, Kobori M, Shinmoto H, Tanabe M, Tsushida T.
Progressive effects of phloridzin on melanogenesis in B16 mouse melanoma cells
Biosci Biotechnol Biochem
1997
61(12):1963-7.
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Kawachi Y, Nakauchi H, Otsuka F.
Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin
Exp Dermatol
1997
6(3):140-6
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5064
Kobori M, Shinmoto H, Tsushida T, Shinohara K.
Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport.
Cancer Lett
1997
119(2):207-12
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Hirano S.
In vitro and in vivo cytotoxic effects of nitric oxide on metastatic cells
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Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H.
Kappa-casein suppresses melanogenesis in cultured pigment cells.
Pigment Cell Res
1996
9(5):235-9
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Kojima S, Yamaguchi H, Morita K, Ueno Y.
Inhibitory effect of sodium 5,6-benzylidene ascorbate (SBA) on the elevation of melanin biosynthesis induced by ultraviolet-A (UV-A) light in cultured B-16 melanoma cells
Biol Pharm Bull
1995
18(8):1076-80
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5063
Kobori M, Sasaki Y, Shinohara K.
Suppressive effect of spinach extract on the formation of melanin in B16 mouse melanoma cells.
Cytotechnology
1994
14(2):119-22
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9014
M Takagaki, K Honke, T Tsukamoto, S Higashiyama, N Taniguchi, A Makita, I Ohkubo
Zn-alpha 2-glycoprotein Is a Novel Adhesive Protein
Biochem Biophys Res Commun
1994
201 (3), 1339-47
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1160
Yasuto Sasaki, Masuko Kobori, Hironobu Mori, Kazuki Shinohara
Suppression of Melanin Production in a Mouse B16 Melanoma 4A5 Cell Line by a Spinach Extract
Animal Cell Technology: Basic & Applied Aspects
1993
183-188
DOI: 10.1007/978-94-011-2044-9_26
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