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10006
Tomohiro Itoh, Kanako Fukatani, Ayaka Nakashima, Kengo Suzuki
MicroRNA-141-3p and microRNA-200a-3p Regulate α-Melanocyte Stimulating Hormone-Stimulated Melanogenesis by Directly Targeting Microphthalmia-Associated Transcription Factor
Sci Rep
2020
10(1):2149
PubMed ID: 32034251
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12162
Kazuhiro Kagotani, Hiroko Nakayama, Liqing Zang, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Norihiro Nishimura, and Yasuhito Shimada
Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide
Molecules
2020
PubMed ID: 32244349
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12172
Kosuke Nishi, Mizuki Mori, Daisuke Nakayama, Junna Sato, In-Hae Kim, Minju Kim, Songmun Kim & Takuya Sugahara
Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells
Biomedical Dermatology
2020
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11365
Kawasaki T, Sato A, Tominaga Y, Suzuki Y, Oyama T, Tadokoro M, Tsukiyama K, Nokihara K, Zen H.
Photo-Modification of Melanin by a Mid-infrared Free-electron Laser.
Photochem. Photobiol.
2019
PubMed ID: 30613988
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11374
Wang W, Nakashima S, Nakamura S, Oda Y, Matsuda H.
Anti-proliferative effect of auriculataoside A on B16 melanoma 4A5 cells by suppression of Cdc42-Rac1-RhoA signaling protein levels.
J Nat Med
2019
PubMed ID: 30627935
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11473
Wang W, Zhang Y, Nakashima S, Nakamura S, Wang T, Yoshikawa M, Matsuda H.
Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.
J Nat Med
2019
PubMed ID: 30847755
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5791
Takuya Seko, Shintaro Imamura, Kenji Ishihara, Yumiko Yamashita, Michiaki Yamashita
Selenoneine suppresses melanin synthesis by inhibiting tyrosinase in murine B16 melanoma cells and 3D-cultured human melanocytes
Fisheries Science
2019
1–9
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14699
Azumi J, Takeda T, Shimada Y, Aso H, Nakamura T.
The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells
Int J Mol Sci
2019
20(19):4785
PubMed ID: 31561511
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10603
Taira N, Katsuyama Y, Yoshioka M, Okano Y, Masaki H.
3-O-Glyceryl-2-O-hexyl ascorbate suppresses melanogenesis by interfering with intracellular melanosome transport and suppressing tyrosinase protein synthesis.
J Cosmet Dermatol
2018
17(6):1209-1215
PubMed ID: 29115012
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10830
Katsuyama Y, Taira N, Yoshioka M, Okano Y, Masaki H.
3-O-Glyceryl-2-O-hexyl Ascorbate Suppresses Melanogenesis through Activation of the Autophagy System.
Biol. Pharm. Bull.
2018
41:824-827
PubMed ID: 29709921
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11067
Compositions and melanogenesis-inhibitory activities of the extracts of defatted shea (Vitellaria paradoxa) kernels from seven African countries
Journal of Food Composition and Analysis
2018
70, 89-97
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14922
Taira N, Katsuyama Y, Yoshioka M, Muraoka O, Morikawa T.
Structural Requirements of Alkylglyceryl-l-Ascorbic Acid Derivatives for Melanogenesis Inhibitory Activity
Int J Mol Sci
2018
19(4):1144
PubMed ID: 29642633
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10675
Manse Y, Ninomiya K, Nishi R, Hashimoto Y, Chaipech S, Muraoka O, Morikawa T.
Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga.
Molecules
2017
22:
PubMed ID: 29261124
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14436
Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada-Nishida, Takahiro Imagawa, Mami Imamura-Mizushima, Yuki Yamano, Kinji Kaname, Sho Nakamura, Toshio Morikawa
Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus
Natural Product Communications
2017
12:1934578X1701200
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14684
Fujihara K, Takahashi K, Koyama K, Kinoshita K.
Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells
J Nat Med
2017
71(4):606-616
PubMed ID: 28497306
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7101
Ninomiya K, Matsumoto T, Chaipech S, Miyake S, Katsuyama Y, Tsuboyama A, Pongpiriyadacha Y, Hayakawa T, Muraoka O, Morikawa T.
Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.
J Nat Med
2016
70:179-89
PubMed ID: 26711832
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12210
Amal Sallam, Amira Mira, Ahmed Ashour, Kuniyoshi Shimizu
Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis
Phytomedicine
2016
23(10):1005-11
PubMed ID: 27444345
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13684
Horiba H, Nakagawa T, Zhu Q, Ashour A, Watanabe A, Shimizu K.
Biological Activities of Extracts from Different Parts of Cryptomeria japonica
Nat Prod Commun
2016
11(9):1337-1342
PubMed ID: 30807038
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14166
Morikawa T, Ninomiya K, Kuramoto H, Kamei I, Yoshikawa M, Muraoka O.
Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis
J Nat Med
2016
70(1):89-101
PubMed ID: 26475459
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14174
Manse Y, Ninomiya K, Nishi R, Kamei I, Katsuyama Y, Imagawa T, Chaipech S, Muraoka O, Morikawa T.
Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit
Bioorg Med Chem
2016
24(23):6215-6224
PubMed ID: 27756508
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14177
Morikawa T, Kitagawa N, Tanabe G, Ninomiya K, Okugawa S, Motai C, Kamei I, Yoshikawa M, Lee IJ, Muraoka O.
Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity
Molecules
2016
21(7):930
PubMed ID: 27447599
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7182
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.
J. Biol. Chem.
2015
290:29781-93
PubMed ID: 26475855
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7574
Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA
Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.
Deep Ocean Water Research
2015
15:117-124
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14531
Hisahiro Kai, Koji Matsuno
Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells
Planta Medica Letters
2015
2:e39-e41
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14960
T. Kikuchi, A. Ikedaya, A. Toda, K. Ikushima, T. Yamakawa, R. Okada, T. Yamada, R. Tanaka
Pyrazole alkaloids from watermelon (Citrullus lanatus) seeds
Phytochem Lett
2015
12:94-97
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14978
Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, Miki H, Himuro Y, Yoshikawa M, Matsuda H.
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna)
Bioorg Med Chem Lett
2015
25(13):2702-6
PubMed ID: 25987378
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15138
Hideko MOTOJIMA, Myra O. VILLAREAL, Sayuri KUME, Konomi MURAKAMI, Hanen NAJJA, Mohamed NEFFATI, Hiroko ISODA
Anti-allergy and Melanogenesis Regulatory Effects of Semi-arid and Arid Land Plants
Journal of Arid Land Studies
2015
25:65-68
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15146
Tanabe G, Sugano Y, Shirato M, Sonoda N, Tsutsui N, Morikawa T, Ninomiya K, Yoshikawa M, Muraoka O.
Total Synthesis of 4,5-Didehydroguadiscine: A Potent Melanogenesis Inhibitor from the Brazilian Medicinal Herb, Hornschuchia obliqua
J Nat Prod
2015
78(7):1536-42
PubMed ID: 26135746
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15241
Molina-Guijarro JM, García C, Macías Á, García-Fernández LF, Moreno C, Reyes F, Martínez-Leal JF, Fernández R, Martínez V, Valenzuela C, Lillo MP, Galmarini CM.
Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death
PLoS One
2015
10(10):e0140782
PubMed ID: 26474061
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15286
Yuki Ohno, Shiori Kondo, Kiho Tajima, Toshiyuki Shibata, Tomohiro Itoh
Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells
Natural Product Communications
2015
16:1934578X2110192
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4813
Arung ET, Kuspradini H, Kusuma IW, Bang TH, Yamashita S, Katakura Y, Shimizu K
Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays
J Applied Pharmaceutical Science
2015
5:39-43
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14696
Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori Kumazawa
Anti-melanogenic compounds in Rubus croceacanthus
Journal of Berry Research
2014
4:127-135
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5330
Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.
Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
Bioorg Med Chem
2013
21(5):1043-9
PubMed ID: 23376010
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6320
Shono M, Yoshioka R, Chatani Y, Hirai Y.
Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Cell Struct Funct
2013
38(1):97-107
PubMed ID: 23546178
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5627
Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M.
Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica.
J Nat Prod
2012
75(8):1425-30
PubMed ID: 22834923
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7618
Yoshioka S, Terashita T, Yoshizumi H, Shirasaka N.
Inhibitory effects of whisky polyphenols on melanogenesis in mouse B16 melanoma cells.
Biosci. Biotechnol. Biochem.
2011
75:2278-82
PubMed ID: 22146709
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8108
Fujita S, Ninomiya M, Efdi M, Ohguchi K, Nozawa Y, Koketsu M.
Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw.
Nat. Prod. Res.
2010
24:1630-6
PubMed ID: 20954090
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8400
Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.
Biol. Pharm. Bull.
2010
33:122-4
PubMed ID: 20045948
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8513
Matsuyama K, Villareal MO, El Omri A, Han J, Kchouk ME, Isoda H.
Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells.
J Nat Med
2009
63:468-72
PubMed ID: 19685105
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8661
Ohguchi K, Ito M, Yokoyama K, Iinuma M, Itoh T, Nozawa Y, Akao Y.
Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells.
Biol. Pharm. Bull.
2009
32:308-10
PubMed ID: 19182396
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8715
Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.
Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.
J. Agric. Food Chem.
2008
56:10515-20
PubMed ID: 18959405
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6287
Roy MK, Kobori M, Takenaka M, Nakahara K, Shinmoto H, Isobe S, Tsushida T.
Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).
Phytother Res
2007
21(3):245-50
PubMed ID: 17163581
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15556
Kuniyoshi Shimizu, Shoko Fukunaga, Keisuke Yoshikawa, Ryuichiro Kondo
Screening of extracts of Japanese woods for melanin biosynthesis inhibition
Journal of Wood Science
2007
53:153-160
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3313
Shoji, Toshihiko, Masumoto, Saeko, Moriichi, Nina, Kobori, Masuko, Kanda, Tomomasa, Shinmoto, Hiroshi, Tsushida, Tojiro
Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells.
J Agric Food Chem
2005
53:6105-11
PubMed ID: 16029003
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2846
Fukui M, Nakano-Hashimoto T, Okano K, Maruta Y, Suehiro Y, Hamanaka Y, Yamashita H, Imai K, Kawano MM, Hinoda Y
Therapeutic effect of dendritic cells loaded with a fusion mRNA encoding tyrosinase-related protein 2 and enhanced green fluorescence protein on B16 melanoma.
Tumour Biol
2004
25:252-7
PubMed ID: 15627888
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3221
Ohguchi, Kenji, Banno, Yoshiko, Akao, Yukihiro, Nozawa, Yoshinori
Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.
J Biol Chem
2004
279:3408-12
PubMed ID: 14615486
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13484
Ohara M, Kobayashi M, Fujiwara H, Kitajima S, Mitsuoka C, Watanabe H.
Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea-pigs
Photodermatol Photoimmunol Photomed
2004
20(2):86-92
PubMed ID: 15030593
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13675
Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake, Ryuichiro Kondo, Mototake Tsutsui, Ikuo Sato
Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185
Journal of Wood Science
2003
49:349-354
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14423
Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T.
Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
Cancer Sci
2003
94(3):308-13
PubMed ID: 12824927
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6185
Matsui H, Takahashi T.
Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.
Endocrinology
2001
142(11):4918-29
PubMed ID: 11606460
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14426
Noguchi M, Imaizumi K, Kawabe T, Wakayama H, Horio Y, Sekido Y, Hara T, Hashimoto N, Takahashi M, Shimokata K, Hasegawa Y.
Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer
Cancer Gene Ther
2001
8(6):421-9
PubMed ID: 11498762
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5066
Iwashita K, Kobori M, Yamaki K, Tsushida T.
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells.
Biosci Biotechnol Biochem
2000
64(9):1813-20
PubMed ID: 11055382
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2368
Imaizumi K, Kawabe T, Ichiyama S, Kikutani H, Yagita H, Shimokata K, Hasegawa Y
Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction
Am J Physiol
1999
277(1 Pt 1):L49-57
PubMed ID: 10409230
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5065
Kobori M, Iwashita K, Shinmoto H, Tsushida T.
Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells.
Biosci Biotechnol Biochem
1999
63(4):719-25
PubMed ID: 10361685
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3525
Zhao X1, Wakamatsu Y, Shibahara M, Nomura N, Geltinger C, Nakahara T, Murata T, Yokoyama KK.
Mannosylerythritol lipid is a potent inducer of apoptosis and differentiation of mouse melanoma cells in culture.
Cancer Res
1999
59(2):482-6
PubMed ID: 9927066
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5064
Kobori M, Shinmoto H, Tsushida T, Shinohara K.
Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport.
Cancer Lett
1997
119(2):207-12
PubMed ID: 9570373
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13668
Hirano S.
In vitro and in vivo cytotoxic effects of nitric oxide on metastatic cells
Cancer Lett
1997
115(1):57-62
PubMed ID: 9097979
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6255
Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H.
Kappa-casein suppresses melanogenesis in cultured pigment cells.
Pigment Cell Res
1996
9(5):235-9
PubMed ID: 9014209
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5063
Kobori M, Sasaki Y, Shinohara K.
Suppressive effect of spinach extract on the formation of melanin in B16 mouse melanoma cells.
Cytotechnology
1994
14(2):119-22
PubMed ID: 22358759
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