CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0557 : B16 melanoma 4A5]

587 Silagi S Control of pigment production in mouse melanoma cells in vitro. Evocation and maintenance. J Cell Biol 1969 43:263-74 PubMed ID: 4981070 DOI: 10.1083/jcb.43.2.263

3488 HU F, LESNEY PF. THE ISOLATION AND CYTOLOGY OF TWO PIGMENT CELL STRAINS FROM B-16 MOUSE MELANOMAS Cancer Res 1964 24:1634-43. PubMed ID: 14234007

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22825 Mima Y, Yamada T, Omatsu J, Yamashita T, Suzuki S, Takechi T, Ichikawa M, Yamazaki K, Sato S, Yoshizaki A. Inhibitory Effect of 505 nm Green Light Emitting Diode on Melanin Synthesis in Cellular Experiments and a Human Intervention Study. Acta Derm Venereol 2025 105:adv43441 PubMed ID: 40375536 DOI: 10.2340/actadv.v105.43441

21735 Saito R, Shinozaki Y, Tabata K, Nishinaka Y, Yokoyama K, Kon R, Sakai H, Hosoe T, Ikarashi N. Tokishakuyakusan alleviates ultraviolet-induced skin pigmentation by decreasing the expression of melanogenesis-related enzymes. J Ethnopharmacol 2024 118348 PubMed ID: 38762211 DOI: 10.1016/j.jep.2024.118348

22836 Hisae Aoshima, Ruka Mizuno, Yuho Iwatsu, Shiori Onishi, Sayuri Hyodo, Rinta Ibuki, Hirokazu Kawagishi, Yasukazu Saitoh Inhibitory Effect of 2-Aza-8-oxohypoxanthine on Tyrosinase Activity and Melanin Production Cosmetics 2024 11:43 DOI: 10.3390/cosmetics11020043

17768 Azumi J, Takeda T, Shimada Y, Zhuang T, Tokuji Y, Sakamoto N, Aso H, Nakamura T. Organogermanium THGP Induces Differentiation into M1 Macrophages and Suppresses the Proliferation of Melanoma Cells via Phagocytosis Int J Mol Sci 2023 24(3):1885 PubMed ID: 36768216 DOI: 10.3390/ijms24031885

15286 Yuki Ohno, Shiori Kondo, Kiho Tajima, Toshiyuki Shibata, Tomohiro Itoh Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells Natural Product Communications 2021 16:1934578X2110192 DOI: 10.1177/1934578x211019264

10006 Tomohiro Itoh, Kanako Fukatani, Ayaka Nakashima, Kengo Suzuki MicroRNA-141-3p and microRNA-200a-3p Regulate α-Melanocyte Stimulating Hormone-Stimulated Melanogenesis by Directly Targeting Microphthalmia-Associated Transcription Factor Sci Rep 2020 10(1):2149 PubMed ID: 32034251 DOI: 10.1038/s41598-020-58911-w

12162 Kazuhiro Kagotani, Hiroko Nakayama, Liqing Zang, Yuki Fujimoto, Akihito Hayashi, Ryoji Sono, Norihiro Nishimura, and Yasuhito Shimada Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide Molecules 2020 PubMed ID: 32244349 DOI: 10.3390/molecules25071595

12172 Kosuke Nishi, Mizuki Mori, Daisuke Nakayama, Junna Sato, In-Hae Kim, Minju Kim, Songmun Kim & Takuya Sugahara Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells Biomedical Dermatology 2020 DOI: 10.1186/s41702-020-0061-z

17184 Hiroyuki Akazawa, Takuro Shinozaki, Motohiko Ukiya, Toshihiro Akihisa, Manosroi Jiradej, Harukuni Tokuda, Makoto Fukatsu Biological Activities of Flavonoids from the Wood Extract of Artocarpus heterophyllus L. (Jackfruit) The Natural Products Journal 2020 10:216-225 DOI: 10.2174/2210315508666181018103353

11365 Kawasaki T, Sato A, Tominaga Y, Suzuki Y, Oyama T, Tadokoro M, Tsukiyama K, Nokihara K, Zen H. Photo-Modification of Melanin by a Mid-infrared Free-electron Laser. Photochem. Photobiol. 2019 PubMed ID: 30613988 DOI: 10.1111/php.13079

11374 Wang W, Nakashima S, Nakamura S, Oda Y, Matsuda H. Anti-proliferative effect of auriculataoside A on B16 melanoma 4A5 cells by suppression of Cdc42-Rac1-RhoA signaling protein levels. J Nat Med 2019 PubMed ID: 30627935 DOI: 10.1007/s11418-018-01278-0

11473 Wang W, Zhang Y, Nakashima S, Nakamura S, Wang T, Yoshikawa M, Matsuda H. Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds. J Nat Med 2019 PubMed ID: 30847755 DOI: 10.1007/s11418-018-01276-2

5791 Takuya Seko, Shintaro Imamura, Kenji Ishihara, Yumiko Yamashita, Michiaki Yamashita Selenoneine suppresses melanin synthesis by inhibiting tyrosinase in murine B16 melanoma cells and 3D-cultured human melanocytes Fisheries Science 2019 1–9 DOI: 10.1007/s12562-019-01376-2

14699 Azumi J, Takeda T, Shimada Y, Aso H, Nakamura T. The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells Int J Mol Sci 2019 20(19):4785 PubMed ID: 31561511 DOI: 10.3390/ijms20194785

19280 Tanabe G, Manse Y, Ogawa T, Sonoda N, Marumoto S, Ishikawa F, Ninomiya K, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T Total Synthesis of γ-Alkylidenebutenolides, Potent Melanogenesis Inhibitors from Thai Medicinal Plant Melodorum fruticosum J Org Chem 2018 83(15):8250-8264 PubMed ID: 29972303 DOI: 10.1021/acs.joc.8b00986

10603 Taira N, Katsuyama Y, Yoshioka M, Okano Y, Masaki H. 3-O-Glyceryl-2-O-hexyl ascorbate suppresses melanogenesis by interfering with intracellular melanosome transport and suppressing tyrosinase protein synthesis. J Cosmet Dermatol 2018 17(6):1209-1215 PubMed ID: 29115012 DOI: 10.1111/jocd.12451

10830 Katsuyama Y, Taira N, Yoshioka M, Okano Y, Masaki H. 3-O-Glyceryl-2-O-hexyl Ascorbate Suppresses Melanogenesis through Activation of the Autophagy System. Biol. Pharm. Bull. 2018 41:824-827 PubMed ID: 29709921 DOI: 10.1248/bpb.b17-01042

11067 Compositions and melanogenesis-inhibitory activities of the extracts of defatted shea (Vitellaria paradoxa) kernels from seven African countries Journal of Food Composition and Analysis 2018 70, 89-97 DOI: 10.1016/j.jfca.2018.04.010

14922 Taira N, Katsuyama Y, Yoshioka M, Muraoka O, Morikawa T. Structural Requirements of Alkylglyceryl-l-Ascorbic Acid Derivatives for Melanogenesis Inhibitory Activity Int J Mol Sci 2018 19(4):1144 PubMed ID: 29642633 DOI: 10.3390/ijms19041144

10675 Manse Y, Ninomiya K, Nishi R, Hashimoto Y, Chaipech S, Muraoka O, Morikawa T. Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga. Molecules 2017 22: PubMed ID: 29261124 DOI: 10.3390/molecules22122279

14436 Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada-Nishida, Takahiro Imagawa, Mami Imamura-Mizushima, Yuki Yamano, Kinji Kaname, Sho Nakamura, Toshio Morikawa Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus Natural Product Communications 2017 12:1934578X1701200 DOI: 10.1177/1934578x1701200809

14684 Fujihara K, Takahashi K, Koyama K, Kinoshita K. Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells J Nat Med 2017 71(4):606-616 PubMed ID: 28497306 DOI: 10.1007/s11418-017-1082-9

7101 Ninomiya K, Matsumoto T, Chaipech S, Miyake S, Katsuyama Y, Tsuboyama A, Pongpiriyadacha Y, Hayakawa T, Muraoka O, Morikawa T. Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora. J Nat Med 2016 70:179-89 PubMed ID: 26711832 DOI: 10.1007/s11418-015-0955-z

12210 Amal Sallam, Amira Mira, Ahmed Ashour, Kuniyoshi Shimizu Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis Phytomedicine 2016 23(10):1005-11 PubMed ID: 27444345 DOI: 10.1016/j.phymed.2016.06.014

13684 Horiba H, Nakagawa T, Zhu Q, Ashour A, Watanabe A, Shimizu K. Biological Activities of Extracts from Different Parts of Cryptomeria japonica Nat Prod Commun 2016 11(9):1337-1342 PubMed ID: 30807038

14166 Morikawa T, Ninomiya K, Kuramoto H, Kamei I, Yoshikawa M, Muraoka O. Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis J Nat Med 2016 70(1):89-101 PubMed ID: 26475459 DOI: 10.1007/s11418-015-0941-5

14174 Manse Y, Ninomiya K, Nishi R, Kamei I, Katsuyama Y, Imagawa T, Chaipech S, Muraoka O, Morikawa T. Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit Bioorg Med Chem 2016 24(23):6215-6224 PubMed ID: 27756508 DOI: 10.1016/j.bmc.2016.10.001

14177 Morikawa T, Kitagawa N, Tanabe G, Ninomiya K, Okugawa S, Motai C, Kamei I, Yoshikawa M, Lee IJ, Muraoka O. Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity Molecules 2016 21(7):930 PubMed ID: 27447599 DOI: 10.3390/molecules21070930

7182 Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C. Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis. J. Biol. Chem. 2015 290:29781-93 PubMed ID: 26475855 DOI: 10.1074/jbc.M115.669481

7574 Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan. Deep Ocean Water Research 2015 15:117-124

14531 Hisahiro Kai, Koji Matsuno Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells Planta Medica Letters 2015 2:e39-e41 DOI: 10.1055/s-0035-1557833

14960 T. Kikuchi, A. Ikedaya, A. Toda, K. Ikushima, T. Yamakawa, R. Okada, T. Yamada, R. Tanaka Pyrazole alkaloids from watermelon (Citrullus lanatus) seeds Phytochem Lett 2015 12:94-97 DOI: 10.1016/j.phytol.2015.02.017

14978 Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, Miki H, Himuro Y, Yoshikawa M, Matsuda H. Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna) Bioorg Med Chem Lett 2015 25(13):2702-6 PubMed ID: 25987378 DOI: 10.1016/j.bmcl.2015.04.052

15138 Hideko MOTOJIMA, Myra O. VILLAREAL, Sayuri KUME, Konomi MURAKAMI, Hanen NAJJA, Mohamed NEFFATI, Hiroko ISODA Anti-allergy and Melanogenesis Regulatory Effects of Semi-arid and Arid Land Plants Journal of Arid Land Studies 2015 25:65-68 DOI: 10.14976/jals.25.3_65

15146 Tanabe G, Sugano Y, Shirato M, Sonoda N, Tsutsui N, Morikawa T, Ninomiya K, Yoshikawa M, Muraoka O. Total Synthesis of 4,5-Didehydroguadiscine: A Potent Melanogenesis Inhibitor from the Brazilian Medicinal Herb, Hornschuchia obliqua J Nat Prod 2015 78(7):1536-42 PubMed ID: 26135746 DOI: 10.1021/np500995z

15241 Molina-Guijarro JM, García C, Macías Á, García-Fernández LF, Moreno C, Reyes F, Martínez-Leal JF, Fernández R, Martínez V, Valenzuela C, Lillo MP, Galmarini CM. Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death PLoS One 2015 10(10):e0140782 PubMed ID: 26474061 DOI: 10.1371/journal.pone.0140782

4813 Arung ET, Kuspradini H, Kusuma IW, Bang TH, Yamashita S, Katakura Y, Shimizu K Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays J Applied Pharmaceutical Science 2015 5:39-43 DOI: 10.7324/JAPS.2015.501007

5601 Usui K, Ikeda T, Horibe Y, Nakao M, Hoshino T, Mizushima T. Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers J Dermatol Sci 2015 78(1):67-75 PubMed ID: 25724362 DOI: 10.1016/j.jdermsci.2015.01.014

19157 Ono K, Fujiwara T, Saito K, Nishizawa H, Takahashi N, Suzuki C, Ochi T, Kato H, Ishii Y, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Yamada R, Nakamura Y, Igarashi K, Harigae H. Cytotoxic and melanogenesis-inhibitory activities of limonoids from the leaves of Azadirachta indica (Neem) Chem Biodivers 2014 11(3):451-68 PubMed ID: 24634075 DOI: 10.1002/cbdv.201300348

19278 Matsumoto T, Nakamura S, Nakashima S, Fujimoto K, Yoshikawa M, Ohta T, Ogawa K, Matsuda H. Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis J Nat Prod 2014 77(4):990-9. PubMed ID: 24601675 DOI: 10.1021/np401091f

14696 Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori Kumazawa Anti-melanogenic compounds in Rubus croceacanthus Journal of Berry Research 2014 4:127-135 DOI: 10.3233/jbr-140075

16548 Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T. Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities Chem Biodivers 2014 11(1):73-84 PubMed ID: 24443427 DOI: 10.1002/cbdv.201300266

17155 Shuuichi Akazaki, Toshie Takahashi, Yujiro Nakano, Tomoki Nishida, Hirotarou Mori, Akio Takaoka, Hitomi Aoki, Huayua Chen, Takahiro Kunisada, Kenzo Koike Three-Dimensional Analysis of Melanosomes Isolated from B16 Melanoma Cells by Using Ultra High Voltage Electron Microscopy Microscopy Research 2014 02:1-8 DOI: 10.4236/mr.2014.21001

18807 Zhang J, Koike R, Yamamoto A, Ukiya M, Fukatsu M, Banno N, Miura M, Motohashi S, Tokuda H, Akihisa T. Glycosidic inhibitors of melanogenesis from leaves of Passiflora edulis Chem Biodivers 2013 10(10):1851-65 PubMed ID: 24130028 DOI: 10.1002/cbdv.201300181

18810 Chao HC, Najjaa H, Villareal MO, Ksouri R, Han J, Neffati M, Isoda H. Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells Exp Dermatol 2013 22(2):131-6 PubMed ID: 23362872 DOI: 10.1111/exd.12089

19171 Akihisa T, Orido M, Akazawa H, Takahashi A, Yamamoto A, Ogihara E, Fukatsu M. Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum Chem Biodivers 2013 10(2):167-76 PubMed ID: 23418164 DOI: 10.1002/cbdv.201200251

19172 Kikuchi T, Okada R, Harada Y, Ikushima K, Yamakawa T, Yamada T, Tanaka R. Cucurbitane-type triterpenes from Citrullus lanatus (watermelon) seeds Nat Prod Commun 2013 8(10):1367-9 PubMed ID: 24354176

19176 Kikuchi T, Takebayashi M, Shinto M, Yamada T, Tanaka R. Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds Molecules 2013 18(5):5568-79 PubMed ID: 23673529 DOI: 10.3390/molecules18055568

19177 Tanaka R, Kikuchi T, Nakasuji S, Ue Y, Shuto D, Igarashi K, Okada R, Yamada T. A novel 3α-p-Nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate and two new triterpenoids from the seeds of zucchini (Cucurbita pepo L) Molecules 2013 18(7):7448-59 PubMed ID: 23803716 DOI: 10.3390/molecules18077448

5330 Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M. Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B. Bioorg Med Chem 2013 21(5):1043-9 PubMed ID: 23376010 DOI: 10.1016/j.bmc.2013.01.012

6320 Shono M, Yoshioka R, Chatani Y, Hirai Y. Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics. Cell Struct Funct 2013 38(1):97-107 PubMed ID: 23546178 DOI: 10.1247/csf.12032

15955 Zhang J, Nishimoto Y, Tokuda H, Suzuki N, Yasukawa K, Kitdamrongtham W, Akazawa H, Manosroi A, Manosroi J, Akihisa T. Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood Chem Biodivers 2013 10(10):1866-75 PubMed ID: 24130029 DOI: 10.1002/cbdv.201300182

16299 Nakamura S, Fujimoto K, Matsumoto T, Nakashima S, Ohta T, Ogawa K, Matsuda H, Yoshikawa M. Acylated sucroses and acylated quinic acids analogs from the flower buds of Prunus mume and their inhibitory effect on melanogenesis Phytochemistry 2013 92:128-36 PubMed ID: 23693120 DOI: 10.1016/j.phytochem.2013.04.012

18587 Akihisa T, Takeda A, Akazawa H, Kikuchi T, Yokokawa S, Ukiya M, Fukatsu M, Watanabe K. Melanogenesis-inhibitory and cytotoxic activities of diarylheptanoids from Acer nikoense bark and their derivatives Chem Biodivers 2012 9(8):1475-89 PubMed ID: 22899608 DOI: 10.1002/cbdv.201200024

18796 Kikuchi T, Watanabe K, Tochigi Y, Yamamoto A, Fukatsu M, Ezaki Y, Tanaka R, Akihisa T. Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells Chem Biodivers 2012 9(8):1500-7 PubMed ID: 22899610 DOI: 10.1002/cbdv.201200111

18809 Kikuchi T, Zhang J, Huang Y, Watanabe K, Ishii K, Yamamoto A, Fukatsu M, Tanaka R, Akihisa T. Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia Chem Biodivers 2012 9(7):1221-30 PubMed ID: 22782871 DOI: 10.1002/cbdv.201100350

18816 Akihisa T, Watanabe K, Yamamoto A, Zhang J, Matsumoto M, Fukatsu M. Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus Chem Biodivers 2012 9(8):1490-9 PubMed ID: 22899609 DOI: 10.1002/cbdv.201200030

18819 Fujimoto K, Nakamura S, Nakashima S, Matsumoto T, Uno K, Ohta T, Miura T, Matsuda H, Yoshikawa M. Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis Chem Pharm Bull (Tokyo) 2012 60(9):1188-94. PubMed ID: 22976329 DOI: 10.1248/cpb.c12-00473

18921 Nakamura S, Fujimoto K, Nakashima S, Matsumoto T, Miura T, Uno K, Matsuda H, Yoshikawa M. Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica Chem Pharm Bull (Tokyo) 2012 60(6):752-8 PubMed ID: 22689427 DOI: 10.1248/cpb.60.752

18929 Akihisa T, Tochizawa S, Takahashi N, Yamamoto A, Zhang J, Kikuchi T, Fukatsu M, Tokuda H, Suzuki N. Melanogenesis-inhibitory saccharide fatty acid esters and other constituents of the fruits of Morinda citrifolia (noni) Chem Biodivers 2012 9(6):1172-87 PubMed ID: 22700235 DOI: 10.1002/cbdv.201100349

5627 Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M. Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica. J Nat Prod 2012 75(8):1425-30 PubMed ID: 22834923 DOI: 10.1021/np3001078

7618 Yoshioka S, Terashita T, Yoshizumi H, Shirasaka N. Inhibitory effects of whisky polyphenols on melanogenesis in mouse B16 melanoma cells. Biosci. Biotechnol. Biochem. 2011 75:2278-82 PubMed ID: 22146709 DOI: 10.1271/bbb.100514

18811 Arung ET, Furuta S, Ishikawa H, Tanaka H, Shimizu K, Kondo R. Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3'-O- Z Naturforsch C J Biosci 2011 66(5-6):209-14 PubMed ID: 21812337 DOI: 10.1515/znc-2011-5-603

15716 Hebishima T, Matsumoto Y, Watanabe G, Soma G, Kohchi C, Taya K, Hayashi Y, Hirota Y. Oral administration of immunopotentiator from Pantoea agglomerans 1 (IP-PA1) improves the survival of B16 melanoma-inoculated model mice Exp Anim 2011 60(2):101-9 PubMed ID: 21512265 DOI: 10.1538/expanim.60.101

8108 Fujita S, Ninomiya M, Efdi M, Ohguchi K, Nozawa Y, Koketsu M. Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw. Nat. Prod. Res. 2010 24:1630-6 PubMed ID: 20954090 DOI: 10.1080/14786411003774338

8400 Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M. Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis. Biol. Pharm. Bull. 2010 33:122-4 PubMed ID: 20045948 DOI: 10.1248/bpb.33.122

18805 Nakashima S, Matsuda H, Oda Y, Nakamura S, Xu F, Yoshikawa M. Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells Bioorg Med Chem 2010 18(6):2337-2345 PubMed ID: 20189399 DOI: 10.1016/j.bmc.2010.01.046

19279 Nakamura S, Chen G, Nakashima S, Matsuda H, Pei Y, Yoshikawa M. Brazilian natural medicines. IV. New noroleanane-type triterpene and ecdysterone-type sterol glycosides and melanogenesis inhibitors from the roots of Pfaffia glomerata Chem Pharm Bull (Tokyo) 2010 58(5):690-5 PubMed ID: 20460798 DOI: 10.1248/cpb.58.690

15647 Akihisa T, Seino K, Kaneko E, Watanabe K, Tochizawa S, Fukatsu M, Banno N, Metori K, Kimura Y. Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni) J Oleo Sci 2010 59(1):49-57 PubMed ID: 20032599 DOI: 10.5650/jos.59.49

8513 Matsuyama K, Villareal MO, El Omri A, Han J, Kchouk ME, Isoda H. Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells. J Nat Med 2009 63:468-72 PubMed ID: 19685105 DOI: 10.1007/s11418-009-0355-3

8661 Ohguchi K, Ito M, Yokoyama K, Iinuma M, Itoh T, Nozawa Y, Akao Y. Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells. Biol. Pharm. Bull. 2009 32:308-10 PubMed ID: 19182396 DOI: 10.1248/bpb.32.308

18803 Matsuda H, Nakashima S, Oda Y, Nakamura S, Yoshikawa M. Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells Bioorg Med Chem 2009 17(16):6048-53 PubMed ID: 19615910 DOI: 10.1016/j.bmc.2009.06.057

18812 Fujii T, Saito M. Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells Biosci Biotechnol Biochem 2009 73(9):1989-93 PubMed ID: 19734679 DOI: 10.1271/bbb.90181

19277 Yamaoka Y, Ohguchi K, Itoh T, Nozawa Y, Akao Y. Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells Biosci Biotechnol Biochem 2009 73(6):1429-31 PubMed ID: 19502752 DOI: 10.1271/bbb.80880

8715 Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J. Agric. Food Chem. 2008 56:10515-20 PubMed ID: 18959405 DOI: 10.1021/jf8020877

18680 Hanamura T, Uchida E, Aoki H. Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation Biosci Biotechnol Biochem 2008 72(12):3211-8 PubMed ID: 19060403 DOI: 10.1271/bbb.80421

19282 Ohguchi K, Koike M, Suwa Y, Koshimizu S, Mizutani Y, Nozawa Y, Akao Y. Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells Biosci Biotechnol Biochem 2008 72(4):1107-10 PubMed ID: 18391453 DOI: 10.1271/bbb.70734

18804 Kawano M, Matsuyama K, Miyamae Y, Shinmoto H, Kchouk ME, Morio T, Shigemori H, Isoda H. Antimelanogenesis effect of Tunisian herb Thymelaea hirsuta extract on B16 murine melanoma cells Exp Dermatol 2007 16(12):977-84 PubMed ID: 18031456 DOI: 10.1111/j.1600-0625.2007.00618.x

6287 Roy MK, Kobori M, Takenaka M, Nakahara K, Shinmoto H, Isobe S, Tsushida T. Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica). Phytother Res 2007 21(3):245-50 PubMed ID: 17163581 DOI: 10.1002/ptr.2058

15556 Kuniyoshi Shimizu, Shoko Fukunaga, Keisuke Yoshikawa, Ryuichiro Kondo Screening of extracts of Japanese woods for melanin biosynthesis inhibition Journal of Wood Science 2007 53:153-160 DOI: 10.1007/s10086-006-0824-1

3313 Shoji, Toshihiko, Masumoto, Saeko, Moriichi, Nina, Kobori, Masuko, Kanda, Tomomasa, Shinmoto, Hiroshi, Tsushida, Tojiro Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. J Agric Food Chem 2005 53:6105-11 PubMed ID: 16029003 DOI: 10.1021/jf050418m

17362 Enos Tangke Arung, Keisuke Yoshikawa, Kuniyoshi Shimizu, Ryuichiro Kondo The effect of chlorophorin and its derivative on melanin biosynthesis Holzforschung 2005 59:514-518 DOI: 10.1515/hf.2005.085

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