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Cell No. : Cell Name
RCB0540 : HAL-01  update : 2024/08/30
CommentAcute lymphatic leukemia
Comment from the depositor
Terms and conditionsA prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
Remarks
approver's address
×
English
Address
Tokyo Medical University

6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023 Japan
Dr.OHYASHIKI Kazuma
Fax. +81-3-5381-6651
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Ohyashiki, Kazuma
Originator Ohyashiki, Kazuma
Year of deposit 1990
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 17 years
Tissue blood
Disease name acute lymphatic leukemia
Classification cancer
Year of origin 1989
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_1242
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 15% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 40-47(50) : /42(3),43(3),44(3),45(14),46(21),47(4)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 9
User's Publication 2


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Reference
928  Shimamoto T, Tomoda A, Ishida R, Ohyashiki K.  Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo  Clin Cancer Res  2001  7(3):704-8  PubMed ID: 11297267  
929  Tomoda A, Arai S, Ishida R, Shimamoto T, Ohyashiki K.  An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent  Bioorg Med Chem Lett  2001  11(8):1057-8  PubMed ID: 11327588   DOI: 10.1016/s0960-894x(01)00153-6
37  Ohyashiki K, Ohyashiki J, Iwama H, Hayashi S, Shay J, Toyama K.  Telomerase reactivation in leukemia cells  Int J Oncol  1996  8(3):417-21  PubMed ID: 21544377   DOI: 10.3892/ijo.8.3.417
38  Nishimaki J, Miyazawa K, Gotoh A, Yoshikawa O, Ohyashiki K, Toyama K.  Inhibitory effect of a nucleoside analog, acyclovir, on leukemia cells  Leuk Res  1996  20(5):415-20  PubMed ID: 8683981   DOI: 10.1016/0145-2126(96)00009-4
40  Ohyashiki JH, Ohyashiki K, Shimamoto T, Kawakubo K, Fujimura T, Nakazawa S, Toyama K.  Ecotropic virus integration site-1 gene preferentially expressed in post-myelodysplasia acute myeloid leukemia: possible association with GATA-1, GATA-2, and stem cell leukemia gene expression  Blood  1995  85(12):3713-8  PubMed ID: 7780155  
36  Ohyashiki K, Ohyashiki JH, Fujimura T, Kawakubo K, Shimamoto T, Saito M, Nakazawa S, Toyama K.  Telomere shortening in leukemic cells is related to their genetic alterations but not replicative capability  Cancer Genet Cytogenet  1994  78(1):64-7  PubMed ID: 7987807   DOI: 10.1016/0165-4608(94)90047-7
39  Kawakubo K, Ohyashiki JH, Ohyashiki K, Tauchi T, Kimura N, Nakazawa S, Toyama K.  Hypomethylated status, but not RAG-1, is required for T-cell receptor-beta-chain gene rearrangement in acute leukemia cells  Cancer Genet Cytogenet  1994  78(1):40-5  PubMed ID: 7987804   DOI: 10.1016/0165-4608(94)90044-2
35  Hunger SP, Ohyashiki K, Toyama K, Cleary ML.  Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia  Genes Dev  1992  6(9):1608-20  PubMed ID: 1516826  
1325  Ohyashiki K, Fujieda H, Miyauchi J, Ohyashiki, J H, Tauchi T, Saito M, Nakazawa S, Abe K, Yamamoto K, Clark, S C, et al.  Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3.  Leukemia  1991  5:322-31  PubMed ID: 2027299  

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User's Publication
8398  Ikawa Y, Sugimoto N, Koizumi S, Yachie A, Saikawa Y.  Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene.  J. Pediatr. Hematol. Oncol.  2010  32:4-10  PubMed ID: 20051780   DOI: 10.1097/MPH.0b013e3181c29c3c
2119  Yoshinobu Matsuo, Ayumi Okochi, Toshio Ariyasu, Emi Iimura and Tadao Ohno  Identification of Cell Lines with Variabel Numbers of Tandem Repeat(VNTR) Amplified by Polymerase Chain Reaction  Tiss Cult Res Commun  1996  15:211-219    DOI: 10.11418/jtca1981.15.4_21


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