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細胞番号 : 細胞名
RCB0539 : COS-7  update : 2024/06/01
細胞特性(Comment:英)CITES. A subline of CV-1. Expressing SV40 large T antigen. Productivity of plasmid possessing SV40 ori is higher than COS-1. Require import and export permits according to the Convention on International Trade in Endangered Species (CITES). Origin animal species details
細胞特性(日)CV-1細胞株の亜株。SV40 large T抗原を発現している。SV40 oriを有するプラスミドの複製能はCOS-1よりも高い。ワシントン条約対象。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Todokoro, Kazuo
樹立者 Gluzman, Y.
寄託日 1990
動物種 _monkey < Mammals
動物系統名 African green Origin animal species details
属名 Cercopithecus
種名 aethiops
採取組織 kidney
細胞分類 transformed
入手歴 Arai, Ken-ichi(DNAX)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0224
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
動物種PCR
ウィルス(HIV) (-)
アイソザイム検査 LD, NP, G6PD, AST, MPI
染色体検査 51-129(50) : /52(6),53(15),54(19),55(6),84(1)/
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 3件
Reference(日) 1件
利用者成果(英) 251件
利用者成果(日) 0件

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Reference(英)
266  Prives C, Covey L, Scheller A, Gluzman Y.  DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication  Mol Cell Biol  1983  3(11):1958-66  PubMed ID: 6318076   DOI: 10.1128/mcb.3.11.1958-1966.1983
950  Gluzman Y  SV40-transformed simian cells support the replication of early SV40 mutants.  Cell  1981  23:175-82  PubMed ID: 6260373   DOI: 10.1016/0092-8674(81)90282-8
265  Mellon P, Parker V, Gluzman Y, Maniatis T.   Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system  Cell  1981  27(2 Pt 1):279-88  PubMed ID: 6277501   DOI: 10.1016/0092-8674(81)90411-6

トップへページトップへ
Reference(日)
1712  戸所一雄  アフリカミドリザル : COS7  生体の科学  1992  43:405   

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利用者成果(英)
21680  Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH.  Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism.  iScience  2024  27(3):109107  PubMed ID: 38384847   DOI: 10.1016/j.isci.2024.109107
21731  Ishikawa T, Sugawara K, Zhang J, Funatsu T, Okabe K.  Direct observation of cytoskeleton-dependent trafficking of miRNA visualized by the introduction of pre-miRNA.  iScience  2024  27(2):108811  PubMed ID: 38303695   DOI: 10.1016/j.isci.2024.108811
21758  Nakahara Y, Nakabayashi H, Miyazaki J, Watanabe M, Tamai T, Yajima S.  Polydopamine-Coated Solid Silica Nanoparticles Encapsulating IR-783 Dyes: Synthesis and NIR Fluorescent Cell Imaging.  ACS Omega  2024  9(18):19932-19939  PubMed ID: 38737067   DOI: 10.1021/acsomega.3c09655
21784  Tokoro Y, Nagae M, Nakano M, Harduin-Lepers A, Kizuka Y.  LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping.  J Biol Chem  2024    PubMed ID: 38844136   DOI: 10.1016/j.jbc.2024.107450
21804  Yoshida S, Hasegawa T, Nakamura T, Sato K, Sugeno N, Ishiyama S, Sekiguchi K, Tobita M, Takeda A, Aoki M.  Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.  Cell Death Discov  2024  10(1):290  PubMed ID: 38886344   DOI: 10.1038/s41420-024-02062-8
21810  Hashimoto Y, Kawade H, Bao W, Morii S, Nakano M, Nagae M, Murakami R, Tokoro Y, Nakashima M, Cai Z, Isaji T, Gu J, Nakajima K, Kizuka Y.  The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity.  Biochim Biophys Acta Gen Subj  2024    PubMed ID: 38936637   DOI: 10.1016/j.bbagen.2024.130663
21882  Egami Y, Kawai K, Araki N.  Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages.  Life Sci Alliance  2024  7(10)  PubMed ID: 39084876   DOI: 10.26508/lsa.202402651
22016  Tsutsumi T, Taira S, Matsuda R, Kageyama C, Wada M, Kitayama T, Morioka N, Morita K, Tsuboi K, Yamazaki N, Kido J, Nagata T, Dohi T, Tokumura A.  Lysophospholipase D activity on oral mucosa cells in whole mixed human saliva involves in production of bioactive lysophosphatidic acid from lysophosphatidylcholine  Prostaglandins Other Lipid Mediat  2024  174:106881  PubMed ID: 39134206   DOI: 10.1016/j.prostaglandins.2024.106881
22069  Miki T, Hashimoto M, Takahashi H, Shimizu M, Nakayama S, Furuta T, Mihara H.  De novo designed YK peptides forming reversible amyloid for synthetic protein condensates in mammalian cells.  Nat Commun  2024  15(1):8503  PubMed ID: 39424799   DOI: 10.1038/s41467-024-52708-5
17742  Nakashima S, Matsui T, Fukuda M.  Vps9d1 regulates tubular endosome formation through specific activation of Rab22A  J Cell Sci  2023  136(6):jcs260522  PubMed ID: 36762583   DOI: 10.1242/jcs.260522
19631  Osuka RF, Nagae M, Ohuchi A, Ohno S, Yamaguchi Y, Kizuka Y.  The cancer-associated glycosyltransferase GnT-V (MGAT5) recognizes the N-glycan core via residues outside its catalytic pocket  FEBS Lett  2023  597(24):3102-3113  PubMed ID: 37974463   DOI: 10.1002/1873-3468.14775
19721  Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H.  Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis  Elife  2023  12:e83276  PubMed ID: 37272607   DOI: 10.7554/eLife.83276
21060  Ohsawa Y, Ohtsubo H, Munekane A, Ohkubo K, Murakami T, Fujino M, Nishimatsu SI, Hagiwara H, Nishimura H, Kaneko R, Suzuki T, Tatsumi R, Mizunoya W, Hinohara A, Fukunaga M, Sunada Y.  Circulating α-Klotho counteracts TGF-β-induced sarcopenia.  Am J Pathol  2023    PubMed ID: 36773783   DOI: 10.1016/j.ajpath.2023.01.009
21171  Kastian RF, Baba K, Kaewkascholkul N, Sasaki H, Watanabe R, Toriyama M, Inagaki N.  Dephosphorylation of neural wiring protein shootin1 by PP1 phosphatase regulates netrin-1-induced axon guidance.  J Biol Chem  2023  104687  PubMed ID: 37044214   DOI: 10.1016/j.jbc.2023.104687
21218  Kitakaze K, Ali H, Kimoto R, Takenouchi Y, Ishimaru H, Yamashita A, Ueda N, Tanaka T, Okamoto Y, Tsuboi K.  GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator.  Commun Biol  2023  6(1):524  PubMed ID: 37193762   DOI: 10.1038/s42003-023-04900-4
21332  Ueda H, Tran QTH, Tran LNT, Higasa K, Ikeda Y, Kondo N, Hashiyada M, Sato C, Sato Y, Ashida A, Nishio S, Iwata Y, Iida H, Matsuoka D, Hidaka Y, Fukui K, Itami S, Kawashita N, Sugimoto K, Nozu K, Hattori M, Tsukaguchi H.  Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy.  Sci Rep  2023  13(1):12003  PubMed ID: 37491439   DOI: 10.1038/s41598-023-38588-7
21409  Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, Oyama T, Ishii I.  Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor.  Antioxidants (Basel)  2023  12(8)  PubMed ID: 37627519   DOI: 10.3390/antiox12081523
22018  Nakazawa K, Tsukamoto T, Iwata F.  Scanning ion conductance microscope with a capacitance-compensated current source amplifier  Rev Sci Instrum  2023  94(7):073705  PubMed ID: 37466407   DOI: 10.1063/5.0150948
17530  Miki T, Kajiwara K, Nakayama S, Hashimoto M, Mihara H.  Effects of Hydrophobic Residues on the Intracellular Self-Assembly of De Novo Designed Peptide Tags and Their Orthogonality  ACS Synth Biol  2022  11(6):2144-2153  PubMed ID: 35302350   DOI: 10.1021/acssynbio.2c00058
16658  Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M.  Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells  Cell Chem Biol  2022  S2451-9456(22)00198-2  PubMed ID: 35728598   DOI: 10.1016/j.chembiol.2022.05.006
20740  Kawamura T, Ichikawa M, Hatogai J, Koyama Y, Tachibana M, Kuwahara M, Negishi K, Matsumoto M, Miyazaki M, Ochiai W.  Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.  Biopharm Drug Dispos  2022    PubMed ID: 35748067   DOI: 10.1002/bdd.2324
20803  Hirata T, Takata M, Tokoro Y, Nakano M, Kizuka Y.  Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan.  Commun Biol  2022  5(1):743  PubMed ID: 35915223   DOI: 10.1038/s42003-022-03697-y
20831  Kanno Y, Saito N, Saito R, Kosuge T, Shizu R, Yatsu T, Hosaka T, Nemoto K, Kato K, Yoshinari K.  Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells.  Exp Cell Res  2022  419(2):113333  PubMed ID: 36030969   DOI: 10.1016/j.yexcr.2022.113333
20880  Kanadome T, Hayashi K, Seto Y, Eiraku M, Nakajima K, Nagai T, Matsuda T.  Development of intensiometric indicators for visualizing N-cadherin interaction across cells.  Commun Biol  2022  5(1):1065  PubMed ID: 36207396   DOI: 10.1038/s42003-022-04023-2
20900  Kamiya G, Kitada N, Maki S, Kim SB.  Multiplex quadruple bioluminescent assay system.  Sci Rep  2022  12(1):17485  PubMed ID: 36261452   DOI: 10.1038/s41598-022-20468-1
20954  Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M.  ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.  Nat Commun  2022  13(1):7476  PubMed ID: 36463234   DOI: 10.1038/s41467-022-35230-4
20966  Akino S, Yasujima T, Yamashiro T, Yuasa H.  Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter.  Life Sci Alliance  2022  6(2)  PubMed ID: 36456177   DOI: 10.26508/lsa.202201629
17343  Tomida S, Nagae M, Kizuka Y.  The stem region of α1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity  J Biol Chem  2022  298(12):102676.  PubMed ID: 36336076   DOI: 10.1016/j.jbc.2022.102676
20187  Miki T, Nakai T, Hashimoto M, Kajiwara K, Tsutsumi H, Mihara H.  Intracellular artificial supramolecules based on de novo designed Y15 peptides.  Nat Commun  2021  12(1):3412  PubMed ID: 34099696   DOI: 10.1038/s41467-021-23794-6
20262  Yamashita J, Nishiike Y, Fleming T, Kayo D, Okubo K.  Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka.  Commun Biol  2021  4(1):948  PubMed ID: 34373576   DOI: 10.1038/s42003-021-02476-5
20269  Motoike S, Taguchi K, Harada K, Asano M, Hide I, Tanaka S, Irifune M, Sakai N.  Syntaxin 3 interacts with serotonin transporter and regulates its function.  J Pharmacol Sci  2021  145(4):297-307  PubMed ID: 33712280   DOI: 10.1016/j.jphs.2021.01.007
16137  Takashima Y, Ishikawa K, Miyawaki R, Ogawa M, Ishii T, Misaka T, Kobayashi S.  Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity  J Agric Food Chem  2021  69(33):9585-9596  PubMed ID: 34346218   DOI: 10.1021/acs.jafc.1c03483
22015  Jomura R, Tanno Y, Akanuma SI, Kubo Y, Tachikawa M, Hosoya KI.  Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes  Am J Physiol Gastrointest Liver Physiol  2021  321(2):G113-G122  PubMed ID: 34075817   DOI: 10.1152/ajpgi.00143.2021
13115  Urabe T, Yanase Y, Motoike S, Harada K, Hide I, Tanaka S, Tsutsumi YM, Kawamoto M, Sakai N.  Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria.  Eur J Pharmacol  2020    PubMed ID: 32681942   DOI: 10.1016/j.ejphar.2020.173303
13197  Yahiro Y, Maeda S, Morikawa M, Koinuma D, Jokoji G, Ijuin T, Komiya S, Kageyama R, Miyazono K, Taniguchi N.  BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts.  Bone Res  2020    PubMed ID: 32923015   DOI: 10.1038/s41413-020-00106-0
13243  Kasai K, Kuroda Y, Takabuchi Y, Nitta A, Kobayashi T, Nozaka H, Miura T, Nakamura T.  Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis.  Biochem Biophys Res Commun  2020    PubMed ID: 32993960   DOI: 10.1016/j.bbrc.2020.08.093
13610  Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M.  PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells  Genes Cells  2020  25(6):375-390  PubMed ID: 32181976   DOI: 10.1111/gtc.12766
16883  Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.  Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines  Toxicol In Vitro  2020  69:104999.  PubMed ID: 32949729   DOI: 10.1016/j.tiv.2020.104999
22017  Inoue N, Saito T, Wada I.  Unveiling a novel function of CD9 in surface compartmentalization of oocytes  Development  2020  147(15):dev189985  PubMed ID: 32665248   DOI: 10.1242/dev.189985
11407  Ohara-Imaizumi M, Aoyagi K, Yamauchi H, Yoshida M, Mori MX, Hida Y, Tran HN, Ohkura M, Abe M, Akimoto Y, Nakamichi Y, Nishiwaki C, Kawakami H, Hara K, Sakimura K, Nagamatsu S, Mori Y, Nakai J, Kakei M, Ohtsuka T.  ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.  Cell Rep  2019    PubMed ID: 30699350   DOI: 10.1016/j.celrep.2018.12.106
11450  Shimahara Y, Sugawara K, Kojo KH, Kawai H, Yoshida Y, Hasezawa S, Kutsuna N.  IMACEL: A cloud-based bioimage analysis platform for morphological analysis and image classification.  PLoS ONE  2019    PubMed ID: 30794647   DOI: 10.1371/journal.pone.0212619
11521  Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G.  Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.  Cell. Mol. Life Sci.  2019    PubMed ID: 30989245   DOI: 10.1007/s00018-019-03091-8
11706  Jun Miyazaki, Yasunobu Toumon  Label-free dynamic imaging of mitochondria and lysosomes within living cells via simultaneous dual-pump photothermal microscopy  Biomedical Optics Express  2019    PubMed ID: 31799051   DOI: 10.1364/BOE.10.005852
11751  Shinoda H, Lu K, Nakashima R, Wazawa T, Noguchi K, Matsuda T, Nagai T.  Acid-Tolerant Reversibly Switchable Green Fluorescent Protein for Super-resolution Imaging under Acidic Conditions.  Cell Chem Biol  2019    PubMed ID: 31422907   DOI: 10.1016/j.chembiol.2019.07.012
9468  Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma  Induction of Lipid Droplets in Non-Macrophage Cells as Well as Macrophages by Liposomes and Exosomes  Biochem Biophys Res Commun  2019  510(1):184-190  PubMed ID: 30678809   DOI: 10.1016/j.bbrc.2019.01.078
9621  Kota Abe, Atsuko Shimada, Sayaka Tayama, Hotaka Nishikawa, Takuya Kaneko, Sachiko Tsuda, Akari Karaiwa, Takaaki Matsui , Tohru Ishitani, Hiroyuki Takeda  Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite  Cell Rep  2019  27(3):928-939.e4  PubMed ID: 30995487   DOI: 10.1016/j.celrep.2019.03.068
12410  Asano M, Motoike S, Yokota C, Usuki N, Yamamoto H, Urabe T, Katarao K, Hide I, Tanaka S, Kawamoto M, Irifune M, Sakai   SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism  harmacol Sci . 2019 Jan;139(1):29-36  2019  harmacol Sci . 2019 Jan;139(1):29-36  PubMed ID: 30522963   DOI: 10.1016/j.jphs.2018.11.005
7005  Hori T, Okuno T, Hirata K, Yamashita K, Kawano Y, Yamamoto M, Hato M, Nakamura M, Shimizu T, Yokomizo T, Miyano M, Yokoyama S.  Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1.  Nat. Chem. Biol.  2018  14:262-269  PubMed ID: 29309055   DOI: 10.1038/nchembio.2547
19246  Hemmi M, Ikeda Y, Shindo Y, Nakajima T, Nishiyama S, Oka K, Sato M, Hiruta Y, Citterio D, Suzuki K.  Highly Sensitive Bioluminescent Probe for Thiol Detection in Living Cells  Chem Asian J  2018  13(6):648-655  PubMed ID: 29359483   DOI: 10.1002/asia.201701774
11078  Maeda T, Suetake H, Odaka T, Miyadai T.  Original Ligand for LTβR Is LIGHT: Insight into Evolution of the LT/LTβR System.  J. Immunol.  2018  201(1):202-214  PubMed ID: 29769272   DOI: 10.4049/jimmunol.1700900
11084  Kondo D, Noguchi A, Takahashi I, Kubota H, Yano T, Sato Y, Toyono M, Sawaishi Y, Takahashi T.  A novel ZC4H2 gene mutation, K209N, in Japanese siblings with arthrogryposis multiplex congenita and intellectual disability: characterization of the K209N mutation and clinical findings.  Brain Dev.  2018  40(9):760-767  PubMed ID: 29803542   DOI: 10.1016/j.braindev.2018.05.003
11159  Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.  TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.  PLoS ONE  2018  13(8):e0200988  PubMed ID: 30086173   DOI: 10.1371/journal.pone.0200988
11184  Nagae M, Kizuka Y, Mihara E, Kitago Y, Hanashima S, Ito Y, Takagi J, Taniguchi N, Yamaguchi Y.  Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V.  Nat Commun  2018  9(1):3380  PubMed ID: 30140003   DOI: 10.1038/s41467-018-05931-w
4180  Miyahara T, Adachi N, Seki T, Hide I, Tanaka S, Saito N, Irifune M, Sakai N.  Propofol induced diverse and subtype-specific translocation of PKC families.  J. Pharmacol. Sci.  2018    PubMed ID: 29699771   DOI: 10.1016/j.jphs.2018.03.008
4181  Kitaoka S, Hatogai J, Ochiai W, Sugiyama K.  Zonation of the drug-metabolizing enzyme cytochrome P450 3A in infant mice begins in pre-weaning period.  J Toxicol Sci  2018    PubMed ID: 29540656   DOI: 10.2131/jts.43.223
4182  Fujiwara S, Matsui TS, Ohashi K, Deguchi S, Mizuno K.  Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.  PLoS ONE  2018    PubMed ID: 29672603   DOI: 10.1371/journal.pone.0195124
7017  Kizuka Y, Nakano M, Yamaguchi Y, Nakajima K, Oka R, Sato K, Ren CT, Hsu TL, Wong CH, Taniguchi N.  An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3.  Cell Chem Biol  2017  24(12):1467-1478  PubMed ID: 29033318   DOI: 10.1016/j.chembiol.2017.08.023
10250  Moritani C, Kawakami K, Fujita A, Kawakami K, Hatanaka T, Tsuboi S.  Anti-oxidative Activity of Hydrolysate from Rice Bran Protein in HepG2 Cells.  Biol. Pharm. Bull.  2017  40:984-991  PubMed ID: 28381791   DOI: 10.1248/bpb.b16-00971
10263  Inoue T, Takemura M, Fushimi N, Fujimori Y, Onozato T, Kurooka T, Asari T, Takeda H, Kobayashi M, Nishibe H, Isaji M.  Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation.  Eur. J. Pharmacol.  2017  806:25-31  PubMed ID: 28410751   DOI: 10.1016/j.ejphar.2017.04.010
10416  Kubota Y, Fujioka K, Takekawa M.  WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins.  PLoS ONE  2017  12:e0180714  PubMed ID: 28686627   DOI: 10.1371/journal.pone.0180714
4549  Takano T, Wu M, Nakamuta S, Naoki H, Ishizawa N, Namba T, Watanabe T, Xu C, Hamaguchi T, Yura Y, Amano M, Hahn KM, Kaibuchi K.  Discovery of long-range inhibitory signaling to ensure single axon formation.  Nat Commun  2017  8(1):13  PubMed ID: 28652571   DOI: 10.1038/s41467-017-00044-2
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14125  Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T.  Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization  Nature  2016  534(7608):566-9  PubMed ID: 27309808   DOI: 10.1038/nature18596
14150  Higashio H, Satoh Y, Saino T.  Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37  Sci Rep  2016  ;6:22539  PubMed ID: 26931073   DOI: 10.1038/srep22539
14703  Tatani K, Hiratochi M, Kikuchi N, Kuramochi Y, Watanabe S, Yamauchi Y, Itoh F, Isaji M, Shuto S.  Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout  J Med Chem  2016  59(8):3719-31  PubMed ID: 27007871   DOI: 10.1021/acs.jmedchem.5b01884
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7453  Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C.  Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin.  J. Biol. Chem.  2015  290:13202-14  PubMed ID: 25750127   DOI: 10.1074/jbc.M115.638759
9407  Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda  The Transcription Factor Foxc1 Is Necessary for Ihh-Gli2-regulated Endochondral Ossification  Nat Commun  2015  6:6653  PubMed ID: 25808752   DOI: 10.1038/ncomms7653
15004  Tsukada C, Saito T, Maekawa M, Mano N, Oda A, Hirasawa N, Hiratsuka M.  Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation  Drug Metab Pharmacokinet  2015  30(5):366-73  PubMed ID: 26427316   DOI: 10.1016/j.dmpk.2015.07.003
10473  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.  The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy  PLoS One  2015  10(7):e0133713  PubMed ID: 26226340   DOI: 10.1371/journal.pone.0133713
7579  Suzuki-Nakagawa C, Nishimura M, Tsukamoto T, Aoyama S, Ebihara A, Suzuki F, Nakagawa T.  Participation of the extracellular domain in (pro)renin receptor dimerization.  Biochem. Biophys. Res. Commun.  2014  444:461-6  PubMed ID: 24472541   DOI: 10.1016/j.bbrc.2014.01.073
13882  Yamagishi N, Nakao R, Kondo R, Nishitsuji M, Saito Y, Kuga T, Hatayama T, Nakayama Y.  Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein  Biochem Biophys Res Commun  2014  448(4):430-6  PubMed ID: 24796664   DOI: 10.1016/j.bbrc.2014.04.125
14397  Takeda A, Tsubaki T, Sagae N, Onda Y, Inada Y, Mochizuki T, Okumura K, Kikuyama S, Kobayashi T, Iwamuro S.  Bacterial toxin-inducible gene expression of cathelicidin-B1 in the chicken bursal lymphoma-derived cell line DT40: functional characterization of cathelicidin-B1  Peptides  2014  59:94-10  PubMed ID: 24984089   DOI: 10.1016/j.peptides.2014.06.012
15874  Takaoka M, Saito H, Takenaka K, Miki Y, Nakanishi A.  BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC  Cancer Res  2014  74(5):1518-28  PubMed ID: 24448238   DOI: 10.1158/0008-5472.CAN-13-0504
17140  Koji Yoshida, Ah-Mee Park, Shingen Ozaki, Hiroshi Munakata  Interaction of calcium- and integrin-binding protein 1 with integrin <i>α</i>11 and its possible involvement in pulmonary fibrosis  Advances in Biological Chemistry  2014  04:59-66    DOI: 10.4236/abc.2014.41009
17148  Kano T, Kouzuki T, Mizuno S, Ueda S, Yamanoue M, Sakane F, Saito N, Shirai Y.  Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ  Biochem Biophys Res Commun  2014  447(1):89-94  PubMed ID: 24695318   DOI: 10.1016/j.bbrc.2014.03.113
18773  Obara G, Toyohira Y, Inagaki H, Takahashi K, Horishita T, Kawasaki T, Ueno S, Tsutsui M, Sata T, Yanagihara N.  Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells  J Pharmacol Sci  2013  121(2):138-47  PubMed ID: 23370666   DOI: 10.1254/jphs.12164fp
15943  Tsuyoshi KIMURA, Yukie KANDA, Asami SANO, Kwangwoo NAM, Yoshihiro SASAKI, Kazunari AKIYOSHI, Toshiya FUJISATO, Akio KISHIDA  High Hydrostatic Pressurized Lipoplex Enhances Transfection Efficiency In Vitro  Advanced Biomedical Engineering  2013  2:80-83    DOI: 10.14326/abe.2.80
15956  Nishimoto T, Kashiwagi K, Saito N, Shirai Y.  Both C1B domain and pseudosubstrate region are necessary for saturated fatty acid-induced translocation of εPKC to the plasma membrane: distinct role of intramolecular domains for different translocation  Biochem Biophys Res Commun  2013  432(2):384-8  PubMed ID: 23353652   DOI: 10.1016/j.bbrc.2013.01.048
18585  Matsubara T, Ikeda M, Kiso Y, Sakuma M, Yoshino K, Sakane F, Merida I, Saito N, Shirai Y.  c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218  J Biol Chem  2012  287(8):5507-17  PubMed ID: 22199356   DOI: 10.1074/jbc.M111.296897
18590  Ogata M, Awaji T, Iwasaki N, Fujimaki R, Takizawa M, Maruyama K, Iwamoto Y, Uchigata Y.  A new mitochondrial pH biosensor for quantitative assessment of pancreatic β-cell function  Biochem Biophys Res Commun  2012  421(1):20-6  PubMed ID: 22465007   DOI: 10.1016/j.bbrc.2012.03.093
18728  Sugimoto M, Sugimoto Y.  Variant in the 5' untranslated region of insulin-like growth factor 1 receptor is associated with susceptibility to mastitis in cattle  G3 (Bethesda)  2012  2(9):1077-84  PubMed ID: 22973545   DOI: 10.1534/g3.112.003095
19140  Y. Goto, M. Kajiwara, Y. Yanagisawa, H. Hirose, T. Yoshimi, M. Umemura, H. Nakano, S. Takahashi, Y. Shida, T. Iguchi, Y. Takahashi, T. Miura  Detection of vertebrate-type steroid hormones and their converting activities in the neogastropod Thais clavigera (Kuster, 1858)  Journal of Molluscan Studies  2012  78:197-204    DOI: 10.1093/mollus/eys001
10965  Makoto Ayaori, Emi Yakushiji, Masatsune Ogura, Kazuhiro Nakaya, Tetsuya Hisada, Harumi Uto-Kondo, Shunichi Takiguchi, Yoshio Terao, Makoto Sasaki, Tomohiro Komatsu, Maki Iizuka, Makiko Yogo, Yoshinari Uehara, Hiroyuki Kagechika, Tsuyoshi Nakanishi, Katsunori Ikewaki  Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages  Biochim Biophys Acta  2012  1821(4):561-72  PubMed ID: 22353356   DOI: 10.1016/j.bbalip.2012.02.004
7728  Kimura S, Nakagawa T, Matsuo Y, Ishida Y, Okamoto Y, Hayashi M.  JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats.  Eur. J. Pharmacol.  2011  668:331-6  PubMed ID: 21810422   DOI: 10.1016/j.ejphar.2011.07.015
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15351  Terao Y, Ayaori M, Ogura M, Yakushiji E, Uto-Kondo H, Hisada T, Ozasa H, Takiguchi S, Nakaya K, Sasaki M, Komatsu T, Iizuka M, Horii S, Mochizuki S, Yoshimura M, Ikewaki K.  Effect of sulfonylurea agents on reverse cholesterol transport in vitro and vivo  J Atheroscler Thromb  2011  18(6):513-30  PubMed ID: 21636950   DOI: 10.5551/jat.7641
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8373  Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, Uchikawa S, Takaishi H, Matsumoto M, Chiba K, Horiuchi K, Toyama Y.  Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages.  J. Immunol.  2010  184:2442-8  PubMed ID: 20118276   DOI: 10.4049/jimmunol.0901188
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19250  Fukuda T, Sugita S, Inatome R, Yanagi S.  CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration  J Biol Chem  2010  285(52):40554-61  PubMed ID: 20956536   DOI: 10.1074/jbc.M110.179481
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15644  Kwang-Il Kim, Jae-Woo Lee, Yoshihiro Ito, Jeong-Hwa Kang, Kwang-Sup Song, Eui-Chan Jang, Tae-Il Son  Preparation of photo-reactive azidophenyl chitosan derivative for immobilization of growth factors  Journal of Applied Polymer Science  2010      DOI: 10.1002/app.32179
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8665  Tanimura A, Morita T, Nezu A, Shitara A, Hashimoto N, Tojyo Y.  Use of Fluorescence Resonance Energy Transfer-based Biosensors for the Quantitative Analysis of Inositol 1,4,5-Trisphosphate Dynamics in Calcium Oscillations.  J. Biol. Chem.  2009  284:8910-7  PubMed ID: 19158094   DOI: 10.1074/jbc.M805865200
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18473  Uekusa H, Namimatsu M, Hiwatashi Y, Akimoto T, Nishida T, Takahashi S, Takahashi Y.  Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway  Biochem Biophys Res Commun  2009  380(3):673-8  PubMed ID: 19285020   DOI: 10.1016/j.bbrc.2009.01.158
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6533  Arthritis Rheum  Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene.  Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H.  2009  60(1):166-78  PubMed ID: 19116917   DOI: 10.1002/art.24243
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18305  Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N.  Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis   J Biol Chem  2008  283(28):19854-63  PubMed ID: 18499672   DOI: 10.1074/jbc.M801492200
18415  Tojyo Y, Morita T, Nezu A, Tanimura A.  The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca(2+) store  J Pharmacol Sci  2008  107(2):138-50  PubMed ID: 18544901   DOI: 10.1254/jphs.08021fp
18420  Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.  Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression  Biochem Biophys Res Commun  2008  371(1):44-9  PubMed ID: 18407829   DOI: 10.1016/j.bbrc.2008.03.155
8771  Shimotori M, Maruyama H, Nakamura G, Suyama T, Sakamoto F, Itoh M, Miyabayashi S, Ohnishi T, Sakai N, Wataya-Kaneda M, Kubota M, Takahashi T, Mori T, Tamura K, Kageyama S, Shio N, Maeba T, Yahagi H, Tanaka M, Oka M, Sugiyama H, Sugawara T, Mori N, Tsukamoto H, Tamagaki K, Tanda S, Suzuki Y, Shinonaga C, Miyazaki J, Ishii S, Gejyo F.  Novel mutations of the GLA gene in Japanese patients with Fabry disease and their functional characterization by active site specific chaperone.  Hum. Mutat.  2008  29:331  PubMed ID: 18205205   DOI: 10.1002/humu.9520
18677  Sato M, Amemiya K, Hayakawa S, Munakata H.  Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells  Cell Biochem Funct  2008  26(6):676-83  PubMed ID: 18646256   DOI: 10.1002/cbf.1492
18696  Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y.  Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region  J Biol Chem  2008  283(5):2543-53  PubMed ID: 18055463   DOI: 10.1074/jbc.M707781200
18697  Tsutsui K, Inoue K, Miyabara H, Suzuki S, Ogura Y, Haraguchi S.  7Alpha-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms  J Neurosci  2008  28(9):2158-67  PubMed ID: 18305249   DOI: 10.1523/JNEUROSCI.3562-07.2008
19268  Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M.  Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models  J Pharmacol Exp Ther  2008  327(1):268-76  PubMed ID: 18583547   DOI: 10.1124/jpet.108.140210
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3587  Koyama T, Iwamuro S.  Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic Brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica.  Zoolog Sci  2008  25(5):487-91  PubMed ID: 18558801   DOI: 10.2108/zsj.25.487
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