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Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
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Langmuir
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PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.
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Zoolog Sci
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Hypomorphic mutation in mouse Nppc gene causes retarded bone growth due to impaired endochondral ossification.
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Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1
Mol Endocrinol
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Granulogenesis in non-neuroendocrine COS-7 cells induced by EGFP-tagged chromogranin A gene transfection: identical and distinct distribution of CgA and EGFP.
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C-terminal region regulates the functional expression of human noradrenaline transporter splice variants
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Characterization and identification of a steroid receptor-binding protein, SRB-RGS.
Biol Pharm Bull
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Modification of the titan surface with photoreactive gelatin to regulate cell attachment.
J Biomed Mater Res A
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Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.
Gastroenterology
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Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner.
J Immunol
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S-I Kohno, C Luo, A Nawa, Y Fujimoto, D Watanabe, F Goshima, T Tsurumi, Y Nishiyama
Oncolytic Virotherapy With an HSV Amplicon Vector Expressing Granulocyte-Macrophage Colony-Stimulating Factor Using the Replication-Competent HSV Type 1 Mutant HF10 as a Helper Virus
Cancer Gene Ther
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14 (11), 918-26
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Y-C Jung, E Mizuki, T Akao, J-C Côté
Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells
J Appl Microbiol
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Surface modification of plastic, glass and titanium by photoimmobilization of polyethylene glycol for antibiofouling
Acta Biomater
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The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate
Biochem Biophys Res Commun
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350(1):131-7
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Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2.
Mol Cell Endocrinol
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247(1-2):150-65
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Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma.
Anticancer Res
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A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization.
J Virol
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Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
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138:663-72
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Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
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137:17-25
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2877
Ishizuka M, Kawate H, Takayanagi R, Ohshima H, Tao RH, Hagiwara H
A zinc finger protein TZF is a novel corepressor of androgen receptor.
Biochem Biophys Res Commun
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331:1025-31
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Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.
Proc Natl Acad Sci U S A
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102:8555-60
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Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
Mol Endocrinol
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19:1110-24
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Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki
A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.
Mol Cell Biol
2005
25:1971-9
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Seki, Takahiro, Matsubayashi, Hiroaki, Amano, Taku, Shirai, Yasuhito, Saito, Naoaki, Sakai, Norio
Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC.
Genes Cells
2005
10:225-39
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3201
Yoshida, Koji, Suzuki, Yasuyuki, Saito, Akio, Fukuda, Kanji, Hamanishi, Chiaki, Munakata, Hiroshi
Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin
Biochim Biophys Acta
2005
1725:152-159
PubMed ID: 16099106
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Kawate, Hisaya, Wu, Yin, Ohnaka, Keizo, Tao, Rong-Hua, Nakamura, Kei-Ichiro, Okabe, Taijiro, Yanase, Toshihiko, Nawata, Hajime, Takayanagi, Ryoichi
Impaired nuclear translocation, nuclear matrix targeting, and intranuclear mobility of mutant androgen receptors carrying amino acid substitutions in the deoxyribonucleic acid-binding domain derived from androgen insensitivity syndrome patients.
J Clin Endocrinol Metab
2005
90:6162-9
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Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T.
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
J Biol Chem
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280(18):18525-35
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Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, Hoshika A, Hirohashi S, Yamada T.
Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.
Gastroenterology
2005
129(4):1225-36
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Tsuji T, Kunieda T.
A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.
J Biol Chem
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280(14):14288-92
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Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye
Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines
J Agric Food Chem
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53 (16), 6313-8
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Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E.
Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
Biochim Biophys Acta
2005
1732(1-3):43-52
PubMed ID: 16380173
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Nishimura, Haruki, Nishimura, Masahiro, Oda, Ryo, Yamanaka, Katsuyuki, Matsubara, Takehiro, Ozaki, Yoshie, Sekiya, Kensuke, Hamada, Taizo, Kato, Yukio
Lectins induce resistance to proteases and/or mechanical stimulus in all examined cells--including bone marrow mesenchymal stem cells--on various scaffolds.
Exp Cell Res
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295:119-27
PubMed ID: 15051495
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2869
Saito, Youhei, Doi, Kazuya, Yamagishi, Nobuyuki, Ishihara, Keiichi, Hatayama, Takumi
Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems.
Biochem Biophys Res Commun
2004
314:396-402
PubMed ID: 14733918
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2868
Nakane, Tokio, Satoh, Toshio, Inada, Yoichi, Nakayama, Jun, Itoh, Fumiaki, Chiba, Shigetoshi
Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein.
Biochem Biophys Res Commun
2004
314:1086-92
PubMed ID: 14751244
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3362
Xie, Qiuhong, Matsunaga, Shigeru, Niimi, Setsuko, Ogawa, Setsuko, Tokuyasu, Ken, Sakakibara, Yoshikiyo, Machida, Sachiko
Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells.
DNA Cell Biol
2004
23:111-7
PubMed ID: 15000751
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Shimokawa, Noriaki, Qiu, Chun-Hong, Seki, Takayuki, Dikic, Ivan, Koibuchi, Noriyuki
Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression.
Cell Signal
2004
16:723-9
PubMed ID: 15093613
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Yamauchi, Yoshio, Chang, Catherine C Y, Hayashi, Michi, Abe-Dohmae, Sumiko, Reid, Patrick C, Chang, Ta-Yuan, Yokoyama, Shinji
Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts.
J Lipid Res
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45:1943-51
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Ikeda, Fumiyo, Nishimura, Riko, Matsubara, Takuma, Tanaka, Sakae, Inoue, Jun-ichiro, Reddy, Sakamuri V, Hata, Kenji, Yamashita, Kenji, Hiraga, Toru, Watanabe, Toshiyuki, Kukita, Toshio, Yoshioka, Katsuji, Rao, Anjana, Yoneda, Toshiyuki
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.
J Clin Invest
2004
114:475-84
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3343
Ishihara, Keiichi, Yamagishi, Nobuyuki, Hatayama, Takumi
Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.
Eur J Biochem
2004
271:4552-8
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Tanaka S, Kitagawa K, Sugiura S, Matsuoka-Omura E, Sasaki T, Yagita Y, Hori M.
Infiltrating macrophages as in vivo targets for intravenous gene delivery in cerebral infarction
Stroke
2004
35(8):1968-73
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Hattori M, Suzuki AZ, Higo T, Miyauchi H, Michikawa T, Nakamura T, Inoue T, Mikoshiba K.
Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.
J Biol Chem
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279(12):11967-75
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Okuda T, Sugiyama A, Niidome T, Aoyagi H.
Characters of dendritic poly(L-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro.
Biomaterials
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25(3):537-44
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H Takahashi-Omoe, K Omoe, M Sakaguchi, Y Kameoka, S Matsushita, T Inada
Analysis of protein expression by mammalian cell lines stably expressing lactate dehydrogenase-elevating virus ORF 5 and ORF 6 proteins
Comp Immunol Microbiol Infect Dis
2004
27(2):81-92.
PubMed ID: 14690718
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Tetsuya Fukuda, Hiroyuki Uchida, Motoshi Suzuki, Hideo Miyamoto, Hidetaka Morinaga, Hajime Nawata, Takayuki Uwajima
Transformation products of bisphenol A by a recombinantTrametes villosa laccase and their estrogenic activity
Journal of Chemical Technology & Biotechnology
2004
79:1212-1218
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3198
Numazawa, Satoshi, Ishikawa, Makie, Yoshida, Aya, Tanaka, Sachiko, Yoshida, Takemi
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress.
Am J Physiol Cell Physiol
2003
285:C334-42
PubMed ID: 12700136
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2995
Kazeto, Yukinori, Ijiri, Shigeho, Matsubara, Hajime, Adachi, Shinji, Yamauchi, Kohei
Molecular cloning and characterization of 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase cDNAs from Japanese eel ovary.
J Steroid Biochem Mol Biol
2003
85:49-56
PubMed ID: 12798356
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Ishihara K, Yamagishi N, Hatayama T.
Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function
Biochem J
2003
371(Pt 3):917-25
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Saito Y, Yamagishi N, Ishihara K, Hatayama T.
Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system.
Exp Cell Res
2003
286(2):233-40
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Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, Kitamura T, Murakami Y.
Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.
Oncogene
2003
22(40):6160-5
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9038
Masahiro Nagahama, Shinya Hayashi, Shinsuke Morimitsu, Jun Sakurai
Biological Activities and Pore Formation of Clostridium Perfringens Beta Toxin in HL 60 Cells
J Biol Chem
2003
278 (38), 36934-41
PubMed ID: 12851396
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Keiichi Ishihara, Nobuyuki Yamagishi, Youhei Saito, Hiroaki Adachi, Yasushi Kobayashi, Gen Sobue, Kenzo Ohtsuka, Takumi Hatayama
Hsp105alpha Suppresses the Aggregation of Truncated Androgen Receptor With Expanded CAG Repeats and Cell Toxicity
J Biol Chem
2003
278(27):25143-50
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Inada Y, Nakane T, Chiba S.
Relationship between ligand binding and YIPP motif in the C-terminal region of human AT1 receptor
Biochim Biophys Acta
2003
1640(1):33-41
PubMed ID: 12676352
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Ikeda M, Okai M, Miyoshi T, Tone S, Minatogawa Y
Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha.
Horm Metab Res
2002
34:425-30
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Suganuma T, Kawabata M, Ohshima T, Ikeda MA
Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.
Proc Natl Acad Sci U S A
2002
99:13073-8
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Yamauchi, Yoshio, Abe-Dohmae, Sumiko, Yokoyama, Shinji
Differential regulation of apolipoprotein A-I/ATP binding cassette transporter A1-mediated cholesterol and phospholipid release.
Biochim Biophys Acta
2002
1585:43110
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Ohsaki M, Okuda T, Wada A, Hirayama T, Niidome T, Aoyagi H.
In vitro gene transfection using dendritic poly(L-lysine).
Bioconjug Chem
2002
13(3):510-7
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Irie N, Sakai N, Ueyama T, Kajimoto T, Shirai Y, Saito N.
Subtype- and species-specific knockdown of PKC using short interfering RNA
Biochem Biophys Res Commun
2002
298(5):738-43
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17293
Naoya Kato, Hideo Yoshida, Motoyuki Otsuka, Yasushi Shiratori, Masao Omata
Induction of Proliferation-Related Signals by Hepatitis C Virus
Growth, Proliferation, and Apoptosis in Hepatocytes
2002
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Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S
Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development.
J Biol Chem
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276:3628-34
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Cloning and functional expression of rat kidney dipeptidyl peptidase II.
Biochem J
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Ikeda M, Hirokawa M, Satani N, Kinoshita T, Watanabe Y, Inoue H, Tone S, Ishikawa T, Minatogawa Y
Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA.
Gene
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Mizuarai S, Ono K, You J, Kamihira M, Iijima S.
Protamine-modified DDAB lipid vesicles promote gene transfer in the presence of serum.
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Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E.
The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene.
J Bone Miner Res
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Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S.
Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.
Br J Cancer
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