CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0535 : RAW 264]

716 Ralph P, Nakoinz I Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS. J Immunol 1977 119:950-54 PubMed ID: 894031

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11863 Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S. MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. Gene 2020 PubMed ID: 31654705

6906 Shinjyo N, Nakayama H, Ishimaru K, Hikosaka K, Mi-Ichi F, Norose K, Yoshida H. Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential. J Nat Med 2020 74(1):294-305 PubMed ID: 31728823

11900 Fujihara Y, Abe T, Asawa Y, Nishizawa S, Saijo H, Hikita A, Hoshi K. Influence of Damage-Associated Molecular Patterns from Chondrocytes in Tissue-Engineered Cartilage. Tissue Eng Part A 2020 PubMed ID: 31724485

12001 Yoshimoto Y, Jo JI, Tabata Y. Preparation of antibody-immobilized gelatin nanospheres incorporating a molecular beacon to visualize the biological function of macrophages. Regen Ther 2020 PubMed ID: 31970268

12006 Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S. Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31964526

12009 Bandow K, Hasegawa H, Tomomura M, Tomomura A. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31973822

12016 Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. Sci Rep 2020 PubMed ID: 31969650

12026 Tanaka M, Miyake H, Oka S, Maeda S, Iwasaki K, Mukai T. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochim Biophys Acta Biomembr 2020 PubMed ID: 32004520

12048 Funakoshi-Tago M, Nonaka Y, Tago K, Takeda M, Ishihara Y, Sakai A, Matsutaka M, Kobata K, Tamura H. Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2. Sci Rep 2020 PubMed ID: 32054966

12058 Phan TKT, Shahbazzadeh F, Kihara T. Alpha-mangostin reduces mechanical stiffness of various cells. Hum. Cell 2020 PubMed ID: 32078151

12092 Kamiya Y, Kikuchi T, Goto H, Okabe I, Takayanagi Y, Suzuki Y, Sawada N, Okabe T, Suzuki Y, Kondo S, Hayashi JI, Mitani A. IL-35 and RANKL Synergistically Induce Osteoclastogenesis in RAW264 Mouse Monocytic Cells. Int J Mol Sci 2020 PubMed ID: 32197293

12110 Uchikawa M, Kato M, Nagata A, Sanada S, Yoshikawa Y, Tsunematsu Y, Sato M, Suzuki T, Hashidume T, Watanabe K, Yoshikawa Y, Miyoshi N. Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-A^y mice. Sci Rep 2020 PubMed ID: 32231228

12126 Amlabu WE, Antwi CA, Awandare G, Gwira TM. Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani. PLoS Negl Trop Dis 2020 PubMed ID: 32275665

12130 Sanada S, Suzuki T, Nagata A, Hashidume T, Yoshikawa Y, Miyoshi N. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep 2020 PubMed ID: 32296105

12171 Kazunori Sasaki, Yuri Inami, Kenichi Tominaga, Hideo Kigoshi, Takashi Arimura , and Hiroko Isoda Synthesis of 2-(2-Hydroxyethoxy)-3-hydroxysqualene and Characterization of Its Anti-Inflammatory Effects BioMed Research International 2020 PubMed ID: 32382581

11167 Chaweewannakorn W, Ariyoshi W, Okinaga T, Fujita Y, Maki K, Nishihara T. Ameloblastin attenuates RANKL-mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T-cell cytoplasmic 1 (NFATc1). J. Cell. Physiol. 2019 234(2):1745-175 PubMed ID: 30105896

11173 Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M. The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. J Nat Med 2019 73(1):59-66 PubMed ID: 30116953

11279 Sun S, Li K, Xiao L, Lei Z, Zhang Z. Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7. Biomed. Pharmacother. 2019 PubMed ID: 30396084

11335 Abe T, Sumi K, Kunimatsu R, Oki N, Tsuka Y, Nakajima K, Ando K, Tanimoto K. The effect of mesenchymal stem cells on osteoclast precursor cell differentiation. J Oral Sci 2019 PubMed ID: 30541990

11361 Islam Z, Inui T, Ishibashi O. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30595385

11380 Nemoto R, Fujieda K, Hiruta Y, Hishida M, Ayano E, Maitani Y, Nagase K, Kanazawa H. Liposomes with temperature-responsive reversible surface properties. Colloids Surf B Biointerfaces 2019 PubMed ID: 30641302

11396 Yoshinaga N, Uchida S, Naito M, Osada K, Cabral H, Kataoka K. Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials 2019 PubMed ID: 30669016

11383 Manabe Y, Hirata T, Sugawara T. Inhibitory Effect of Carotenoids on Ligand-induced Lipid Raft Translocation of Immunoreceptors. J Oleo Sci 2019 PubMed ID: 30651415

11389 Wang W, Nakashima KI, Hirai T, Inoue M. Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers. J Nat Med 2019 PubMed ID: 30656541

11457 Takahashi S, Yoshida M, Watanabe MM, Isoda H. Anti-Inflammatory Effects of Aurantiochytrium limacinum 4W-1b Ethanol Extract on Murine Macrophage RAW264 Cells. Biomed Res Int 2019 PubMed ID: 30809537

11437 Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee J, Iimura T, Imai Y. Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin. Bone 2019 PubMed ID: 30771488

11454 Antwi CA, Amisigo CM, Adjimani JP, Gwira TM. In vitro activity and mode of action of phenolic compounds on Leishmania donovani. PLoS Negl Trop Dis 2019 PubMed ID: 30802252

11477 Zhang T, Ono K, Tsutsuki H, Ihara H, Islam W, Akaike T, Sawa T. Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock. Cell Chem Biol 2019 PubMed ID: 30853417

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272

11498 Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M. Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques. J Control Release 2019 PubMed ID: 30936020

11508 Saito H, Tanaka T, Sugahara M, Tanaka S, Fukui K, Wakashima T, Nangaku M. Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet. Lab. Invest. 2019 PubMed ID: 30952940

11539 Suzuka H, Mimura A, Inaoka Y, Murase K. Magnetic Nanoparticles in Macrophages and Cancer Cells Exhibit Different Signal Behavior on Magnetic Particle Imaging. J Nanosci Nanotechnol 2019 PubMed ID: 31039837

11604 Miyazaki Y, Iwaihara Y, Bak J, Nakano H, Takeuchi S, Takeuchi H, Matsui T, Tachikawa D. The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 31221482

11608 Tsuhako R, Yoshida H, Sugita C, Kurokawa M. Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice. J Nat Med 2019 PubMed ID: 31218550

11617 Takeuchi T, Koinuma S, Yokosawa H, Arata Y. An Approach for the Identification of Proteins Modified with ISG15. Methods Mol. Biol. 2019 PubMed ID: 31256383

11704 Miori Tanaka, Ayako Sugama, Kanako Sumi, Kozue Shimizu, Yoshimi Kishimoto, Kazuo Kondo, Kaoruko Iida Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo Nutrition Research 2019 73:58-66

11736 Wang X, Batubara I, Yamauchi K, Mitsunaga T. Identification and structure-activity relationship (SAR) of chemical constituents from Daemonorops draco (Willd.) Blume and selected commercial flavonoids on anti-osteoclastogenesis activity. Fitoterapia 2019 PubMed ID: 31376421

11757 Manabe Y, Takii Y, Sugawara T. Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses. J Nat Med 2019 PubMed ID: 31432315

11772 Okuda-Hanafusa C, Uchio R, Fuwa A, Kawasaki K, Muroyama K, Yamamoto Y, Murosaki S. Turmeronol A and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling. Food Funct 2019 PubMed ID: 31454011

11780 Tan H, Zhao C, Zhu Q, Katakura Y, Tanaka H, Ohnuki K, Shimizu K. Ursolic Acid Isolated from the Leaves of Loquat ( Eriobotrya japonica) Inhibited Osteoclast Differentiation through Targeting Exportin 5. J. Agric. Food Chem. 2019 PubMed ID: 30827108

11793 Mizuno Y, Taguchi T. Growth factor-free, angiogenic hydrogel based on hydrophobically modified Alaska pollock gelatin. J Tissue Eng Regen Med 2019 PubMed ID: 31503405

11801 Ueta M, Takaoka K, Yamamura M, Maeda H, Tamaoka J, Nakano Y, Noguchi K, Kishimoto H. Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro. Mol Med Rep 2019 PubMed ID: 31545488

11810 Ara T, Koide M, Kitamura H, Sogawa N. Effects of shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) on prostaglandin E2 production in lipopolysaccharide-treated mouse macrophage RAW264.7 cells. PeerJ 2019 PubMed ID: 31576251

11873 Ju N, Shimamura M, Hayashi H, Ikeda Y, Yoshida S, Nakamura A, Morishita R, Rakugi H, Nakagami H. Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis. Sci Rep 2019 PubMed ID: 31659208

6944 Yo S, Hamamura K, Mishima Y, Hamajima K, Mori H, Furukawa K, Kondo H, Tanaka K, Sato T, Miyazawa K, Goto S, Togari A. Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging. Int J Mol Sci 2019 20(11):2825 PubMed ID: 31185614

9468 Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma Induction of Lipid Droplets in Non-Macrophage Cells as Well as Macrophages by Liposomes and Exosomes Biochem Biophys Res Commun 2019 510(1):184-190 PubMed ID: 30678809

10512 Sayumi Yamada et al Anti-Inflammatory and Antimicrobial Activities of Aqueous Extracts of Wild Mushrooms from Japan International Journal of Medicinal Mushrooms 2019 21:469-486

10763 Ahmed Elkhateeb, Mona El-Shabrawy, Rehab F. Abdel-Rahman, Mona M. Marzouk, Ahmed H. El-Desoky, El-Sayed S. Abdel-Hameed & Sameh R. Hussein LC-MS-based metabolomic profiling of Lepidium coronopus water extract, anti-inflammatory and analgesic activities, and chemosystematic significance Medicinal Chemistry Research 2019 28:505–514

10848 X.YangaZ.Lei, Y.YuaL.Xiao, D.Cheng, Z.Zhang Phytochemical characteristics of callus suspension culture of Helicteres angustifolia L. and its in vitro antioxidant, antidiabetic and immunomodulatory activities South African Journal of Botany 2019 121:178-185

11886 Ali MFZ, Ohta T, Ido A, Miura C, Miura T. The Dipterose of Black Soldier Fly (Hermetia illucens) Induces Innate Immune Response through Toll-Like Receptor Pathway in Mouse Macrophage RAW264.7 Cells. Biomolecules 2019 PubMed ID: 31683715

11908 Pavillon N, Smith NI. Immune cell type, cell activation, and single cell heterogeneity revealed by label-free optical methods. Sci Rep 2019 PubMed ID: 31745140

11914 Shimakura H, Gen-Nagata F, Haritani M, Furusaki K, Kato Y, Yamashita-Kawanishi N, LE DT, Tsuzuki M, Tohya Y, Kyuwa S, Saito H, Horimoto T, Onodera T, Haga T. Inactivation of human norovirus and its surrogate by the disinfectant consisting of calcium hydrogen carbonate mesoscopic crystals. FEMS Microbiol. Lett. 2019 PubMed ID: 31758686

11948 Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H. Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter. Sci Rep 2019 PubMed ID: 31792273

10342 Fujihara Y, Hikita A, Takato T, Hoshi K. Roles of macrophage migration inhibitory factor in cartilage tissue engineering. J. Cell. Physiol. 2018 233:1490-1499 PubMed ID: 28574571

10432 Tokuyama-Nakai S, Kimura H, Ishihara T, Jisaka M, Yokota K. In Vitro Anti-inflammatory and Antioxidant Activities of 3,5,4'-Trihydroxy-6,7-Methylenedioxyflavone-O-Glycosides and Their Aglycone from Leaves of Polygonum tinctorium Lour. Appl. Biochem. Biotechnol. 2018 184:414-431 PubMed ID: 28721651

10557 Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells. J. Biochem. 2018 163:143-153 PubMed ID: 29048484

10569 Yamaguchi Y, Kanzaki H, Katsumata Y, Itohiya K, Fukaya S, Miyamoto Y, Narimiya T, Wada S, Nakamura Y. Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation. J. Cell. Mol. Med. 2018 22:1138-1147 PubMed ID: 29063666

10614 Stockler-Pinto MB, Soulage CO, Borges NA, Cardozo LFMF, Dolenga CJ, Nakao LS, Pecoits-Filho R, Fouque D, Mafra D. From bench to the hemodialysis clinic: protein-bound uremic toxins modulate NF-κB/Nrf2 expression. Int Urol Nephrol 2018 50:347-354 PubMed ID: 29151180

10645 Nagahara H, Seno T, Yamamoto A, Obayashi H, Inoue T, Kida T, Nakabayashi A, Kukida Y, Fujioka K, Fujii W, Murakami K, Kohno M, Kawahito Y. Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis. Biochem. Biophys. Res. Commun. 2018 495:1901-1907 PubMed ID: 29225172

10696 Kumagai M, Watanabe A, Yoshida I, Mishima T, Nakamura M, Nishikawa K, Morimoto Y. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol. Pharm. Bull. 2018 41:132-137 PubMed ID: 29311475

10704 Hanagata N, Li X, Chen MH, Li J, Hattori S. Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities. Int J Nanomedicine 2018 13:43-62 PubMed ID: 29317815

10708 Kon R, Tsubota Y, Minami M, Kato S, Matsunaga Y, Kimura H, Murakami Y, Fujikawa T, Sakurai R, Tomimoto R, Machida Y, Ikarashi N, Sugiyama K. CPT-11-Induced Delayed Diarrhea Develops via Reduced Aquaporin-3 Expression in the Colon. Int J Mol Sci 2018 19: PubMed ID: 29316651

10711 Egami Y, Araki N. Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis. Microscopy (Oxf) 2018 67:68-74 PubMed ID: 29340604

10714 Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T. Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway. J Clin Biochem Nutr 2018 62:139-147 PubMed ID: 29610553

10782 Miyashita T, Minami K, Ito M, Koizumi R, Sagane Y, Watanabe T, Niwa K. Emu Oil Reduces LPS-Induced Production of Nitric Oxide and TNF-α but not Phagocytosis in RAW 264 Macrophages. J Oleo Sci 2018 67:471-477 PubMed ID: 29526880

10790 El-Desoky AH, Abdel-Rahman RF, Ahmed OK, El-Beltagi HS, Hattori M. Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence. Phytomedicine 2018 42:126-134 PubMed ID: 29655678

10799 Kawai C, Yamauchi A, Kuribayashi F. Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit. Microbiol. Immunol. 2018 62:269-280 PubMed ID: 29573449

11027 Miyake T, Miyake T, Sakaguchi M, Nankai H, Nakazawa T, Morishita R. Prevention of Asthma Exacerbation in a Mouse Model by Simultaneous Inhibition of NF-kB and STAT6 Activation Using a Chimeric Decoy Strategy Mol Ther Nucleic Acids 2018 10:159-169 PubMed ID: 29499930

11198 Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H. Coupling of bone resorption and formation by RANKL reverse signalling. Nature 2018 561(7722):195-200 PubMed ID: 30185903

4050 Mukai Y, Yamanishi R. Retinol but not retinoic acid can enhance the glutathione level, in a manner similar to β-carotene, in a murine cultured macrophage cell line. Food Sci Nutr 2018 PubMed ID: 30258608

11098 Ali MFZ, Yasin IA, Ohta T, Hashizume A, Ido A, Takahashi T, Miura C, Miura T. The silkrose of Bombyx mori effectively prevents vibriosis in penaeid prawns via the activation of innate immunity. Sci Rep 2018 8(1):8836 PubMed ID: 29892000

11116 Tasaka T, Kuwada E, Izuchi Y, Nishigawa R, Yamada H, Unuma H, Tokunaga K, Hayakawa A, Go A, Go K, Uto Y. Concentration-dependent Activation of Inflammatory/Anti-inflammatory Functions of Macrophages by Hydrolyzed Whey Protein. Anticancer Res. 2018 38(7):4299-4304 PubMed ID: 29970565

11122 Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T. Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel. Biomacromolecules 2018 19(8):3280-3290 PubMed ID: 29985587

11186 Kawasaki K, Okuda-Hanafusa C, Aoyagi M, Taoka K, Yamamoto N, Muroyama K, Murosaki S, Yamamoto Y. Inhibitory effect of the compounds from the water extract of Curcuma longa on the production of PGE2 and NO in a macrophage cell line stimulated by LPS. Biosci. Biotechnol. Biochem. 2018 82(12):2109-2117 PubMed ID: 30146952

11200 Odkhuu E, Komatsu T, Koide N, Naiki Y, Takeuchi K, Tanaka Y, Tsolmongyn B, Jambalganiin U, Morita N, Yoshida T, Gotoh B, Yokochi T. Sendai virus C protein limits NO production in infected RAW264.7 macrophages. Innate Immun 2018 24(7):430-438 PubMed ID: 30189760

11074 Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, Matsumoto Y, Nochi T, Watanabe K, Aso H, Tomioka Y. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation. J. Biol. Chem. 2018 293(26):10186-10201 PubMed ID: 29760187

11112 Niino T, Tago K, Yasuda D, Takahashi K, Mashino T, Tamura H, Funakoshi-Tago M. A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis. Biochem. Pharmacol. 2018 155:182-197 PubMed ID: 29940171

11249 Kamiya T, Tanimoto Y, Fujii N, Negishi T, Suzuki T, Hatano T, Arimoto-Kobayashi S. 2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae. Food Chem. Toxicol. 2018 PubMed ID: 30316843

11493 Katsumata Y, Kanzaki H, Honda Y, Tanaka T, Yamaguchi Y, Itohiya K, Fukaya S, Miyamoto Y, Narimiya T, Wada S, Nakamura Y. Single Local Injection of Epigallocatechin Gallate-Modified Gelatin Attenuates Bone Resorption and Orthodontic Tooth Movement in Mice. Polymers (Basel) 2018 10(12) PubMed ID: 30961309

11349 Sugiyama Y, Hiraiwa Y, Hagiya Y, Nakajima M, Tanaka T, Ogura SI. 5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages. BMC Immunol. 2018 PubMed ID: 30567499

4441 Seisho Azuma, Yoshinobu Murakami, Eiko Azuma, Kimiye Baba, Masahiko Taniguchi Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels Trends in Immunotherapy 2018 2

4324 Quan H, Kim Y, Park HC, Yang HC. Effects of phosphatidylserine-containing supported lipid bilayers on the polarization of macrophages. J Biomed Mater Res A 2018 PubMed ID: 29781181

4325 Hoshi K, Yamazaki T, Yoshikawa C, Tsugawa W, Ikebukuro K, Sode K. Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production. Int J Nanomedicine 2018 PubMed ID: 30122920

4326 Saiki P, Nakajima Y, Van Griensven LJLD, Miyazaki K. Real-time monitoring of IL-6 and IL-10 reporter expression for anti-inflammation activity in live RAW 264.7 cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30301531

4327 Abe T, Sumi K, Kunimatsu R, Oki N, Tsuka Y, Nakajima K, Tanimoto K. Dynamic imaging of the effect of mesenchymal stem cells on osteoclast precursor cell chemotaxis for bone defects in the mouse skull. J Dent Sci 2018 PubMed ID: 30895145

4328 Sumi K, Abe T, Kunimatsu R, Oki N, Tsuka Y, Awada T, Nakajima K, Ando K, Tanimoto K. The effect of mesenchymal stem cells on chemotaxis of osteoclast precursor cells. J Oral Sci 2018 PubMed ID: 29925706

4329 Kajita T, Ariyoshi W, Okinaga T, Mitsugi S, Tominaga K, Nishihara T. Mechanisms involved in enhancement of osteoclast formation by activin-A. J. Cell. Biochem. 2018 PubMed ID: 29737562

4330 Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways. Int. Immunopharmacol. 2018 PubMed ID: 30005227

4331 El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S. New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella. Fitoterapia 2018 PubMed ID: 29729401

4332 Tanaka M, Kishimoto Y, Sasaki M, Sato A, Kamiya T, Kondo K, Iida K. Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways. Oxid Med Cell Longev 2018 PubMed ID: 30533177

4333 Kawabata K, Baba N, Sakano T, Hamano Y, Taira S, Tamura A, Baba S, Natsume M, Ishii T, Murakami S, Ohigashi H. Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. Biosci. Biotechnol. Biochem. 2018 PubMed ID: 29165050

4334 Fukai E, Sato H, Watanabe M, Nakae D, Totsuka Y. Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes. Cancer Sci. 2018 PubMed ID: 29444368

4335 Hussain Z, Uyama T, Kawai K, Binte Mustafiz SS, Tsuboi K, Araki N, Ueda N. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Biochim Biophys Acta Mol Cell Biol Lipids 2018 PubMed ID: 29447909

4336 Takahashi S, Sakamaki M, Ferdousi F, Yoshida M, Demura M, Watanabe MM, Isoda H. Ethanol Extract of Aurantiochytrium mangrovei 18W-13a Strain Possesses Anti-inflammatory Effects on Murine Macrophage RAW264 Cells. Front Physiol 2018 PubMed ID: 30319432

4496 Su YW, Chim SM, Zhou L, Hassanshahi M, Chung R, Fan C, Song Y, Foster BK, Prestidge CA, Peymanfar Y, Tang Q, Butler LM, Gronthos S, Chen D, Xie Y, Chen L, Zhou XF, Xu J, Xian CJ. Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats. Bone 2018 116:232-247 PubMed ID: 30125729

4497 Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka T, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N. Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells. Int J Nanomedicine 2018 13:6079-6088 PubMed ID: 30323595

4498 Momozane T, Kawamura T, Itoh Y, Sanosaka M, Sasaki T, Kanzaki R, Ose N, Funaki S, Shintani Y, Minami M, Okumura M, Takemori H. Carnosol suppresses interleukin-6 production in mouse lungs injured by ischemia-reperfusion operation and in RAW264.7 macrophages treated with lipopolysaccharide. Biochem. Cell Biol. 2018 96(6):769-776 PubMed ID: 29958095

4499 Choodej S, Pudhom K, Mitsunaga T. Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. Planta Med. 2018 84(5):329-335 PubMed ID: 28962049

7036 Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y. Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Sci Rep 2017 7:44754 PubMed ID: 28303974

9723 Iwazaki K, Tanaka T, Hozumi Y, Okada M, Tsuchiya R, Iseki K, Topham MK, Kawamae K, Takagi M, Goto K. DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions. J. Cell. Physiol. 2017 232:617-624 PubMed ID: 27312515

9944 Kanzaki H, Shinohara F, Itohiya K, Yamaguchi Y, Katsumata Y, Matsuzawa M, Fukaya S, Miyamoto Y, Wada S, Nakamura Y. RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice. FASEB J. 2017 31:781-792 PubMed ID: 27836987

9964 Shirasugi M, Nishioka K, Yamamoto T, Nakaya T, Kanamura N. Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. Biochem. Biophys. Res. Commun. 2017 482:1122-1128 PubMed ID: 27914813

10001 Quan H, Park HC, Kim Y, Yang HC. Modulation of the anti-inflammatory effects of phosphatidylserine-containing liposomes by PEGylation. J Biomed Mater Res A 2017 105:1479-1486 PubMed ID: 27998010

10074 Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F. Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metab. Clin. Exp. 2017 69:157-170 PubMed ID: 28285646

10085 Ariyoshi W, Okinaga T, Chaweewannakorn W, Akifusa S, Nisihara T. Mechanisms involved in enhancement of matrix metalloproteinase-9 expression in macrophages by interleukin-33. J. Cell. Physiol. 2017 232:3481-3495 PubMed ID: 28105703

10122 Taniguchi M, Ochiai A, Toyoda R, Sato T, Saitoh E, Kato T, Tanaka T. Effects of arginine and leucine substitutions on anti-endotoxic activities and mechanisms of action of cationic and amphipathic antimicrobial octadecapeptide from rice α-amylase. J. Pept. Sci. 2017 23:252-260 PubMed ID: 28185358

10165 Takeuchi T, Sugimoto A, Imazato N, Tamura M, Nakatani S, Kobata K, Arata Y. Glucosamine Suppresses Osteoclast Differentiation through the Modulation of Glycosylation Including O-GlcNAcylation. Biol. Pharm. Bull. 2017 40:352-356 PubMed ID: 28250278

10169 Zhang J, Hiromoto S, Yamazaki T, Huang H, Jia G, Li H, Yuan G. Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method. Mater Sci Eng C Mater Biol Appl 2017 75:1178-1183 PubMed ID: 28415404

10190 Ichimura K, Shimizu T, Matsumoto A, Hirai S, Yokoyama E, Takeuchi H, Yahiro K, Noda M. Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157. Microbiologyopen 2017 6: PubMed ID: 28294553

10215 Yamagata Y, Tomioka H, Sakamoto K, Sato K, Harada H, Ikeda T, Kayamori K. CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma. J. Oral Maxillofac. Surg. 2017 75:2144-2153 PubMed ID: 28399391

10230 Hashiguchi A, Hitachi K, Zhu W, Tian J, Tsuchida K, Komatsu S. Mung bean (Vigna radiata (L.)) coat extract modulates macrophage functions to enhance antigen presentation: A proteomic study. J Proteomics 2017 161:26-37 PubMed ID: 28373035

10285 Fereig RM, Kuroda Y, Terkawi MA, Mahmoud ME, Nishikawa Y. Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice. PLoS ONE 2017 12:e0176324 PubMed ID: 28448521

10288 Kato T, Toyooka T, Ibuki Y, Masuda S, Watanabe M, Totsuka Y. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ 2017 39:12 PubMed ID: 28469735

10335 Wu S, Yano S, Chen J, Hisanaga A, Sakao K, He X, He J, Hou DX. Polyphenols from Lonicera caerulea L. Berry Inhibit LPS-Induced Inflammation through Dual Modulation of Inflammatory and Antioxidant Mediators. J. Agric. Food Chem. 2017 65:5133-5141 PubMed ID: 28573848

10380 Murata K, Motomura Y, Tanaka T, Kanno S, Yano T, Onimaru M, Shimoyama A, Nishio H, Sakai Y, Oh-Hora M, Hara H, Fukase K, Takada H, Masuda S, Ohga S, Yamasaki S, Hara T. Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease. Clin. Exp. Immunol. 2017 190:54-67 PubMed ID: 28640392

10551 Saiki P, Kawano Y, Van Griensven LJLD, Miyazaki K. The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content. Food Funct 2017 8:4150-4158 PubMed ID: 29022634

10915 Effect of Particle Size of Gold Nanoparticles on Matrix Metalloprotease Inhibition, Cytotoxicity and Genotoxicity Journal of Biomaterials and Tissue Engineering, 2017 7, 139-146

10949 Effect of 50-Hz Sinusoidal Magnetic Field on the Production of Superoxide Anion and the Expression of Heat-shock Protein 70 in RAW264 Cells International Journal of Chemistry 2017 9

4526 Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017 818, 7-16 PubMed ID: 28477879

6471 Horigome S, Yoshida I, Ito S, Inohana S, Fushimi K, Nagai T, Yamaguchi A, Fujita K, Satoyama T, Katsuda SI, Suzuki S, Watai M, Hirose N, Mitsue T, Shirakawa H, Komai M. Inhibitory effects of Kaempferia parviflora extract on monocyte adhesion and cellular reactive oxygen species production in human umbilical vein endothelial cells. Eur J Nutr 2017 56(3):949-964 PubMed ID: 26704713

10050 Ha-Eun Yang, Yongjia Li, Akira Nishimura, Huei-Fen Jheng, Ana Yuliana, Ryuji Kitano-Ohue, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada, Tsuyoshi Goto Synthesized Enone Fatty Acids Resembling Metabolites From Gut Microbiota Suppress Macrophage-Mediated Inflammation in Adipocytes Mol Nutr Food Res 2017 Oct;61(10) PubMed ID: 28544341

10076 Yusuke Kono, Taketo Nakai, Hitomi Taguchi, Takuya Fujita Development of Magnetic Anionic Liposome/Atelocollagen Complexes for Efficient Magnetic Drug Targeting Drug Deliv 2017 24(1):1740-1749 PubMed ID: 29141461

7077 Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K. Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. Sci Rep 2016 6:23097 PubMed ID: 26975571

7094 Ryohei Hamaguchi, Yukihiro Kuroda A Novel Biomarker for Cellular Toxicity and Phospholipid Accumulation by Cationic Amphiphilic Drugs. Chromatography 2016 37:35-38

9520 Lu Y, Cao L, Egami Y, Kawai K, Araki N. Cofilin contributes to phagocytosis of IgG-opsonized particles but not non-opsonized particles in RAW264 macrophages. Microscopy (Oxf) 2016 65:233-42 PubMed ID: 26754560

9550 Takeuchi T, Nagasaka M, Shimizu M, Tamura M, Arata Y. N-acetylglucosamine suppresses osteoclastogenesis in part through the promotion of O-GlcNAcylation. Bone Rep 2016 5:15-21 PubMed ID: 28326343

9554 Kuno M, Li G, Moriura Y, Hino Y, Kawawaki J, Sakai H. Acid-inducible proton influx currents in the plasma membrane of murine osteoclast-like cells. Pflugers Arch. 2016 468:837-47 PubMed ID: 26843093

9564 Wada T, Sunaga H, Miyata K, Shirasaki H, Uchiyama Y, Shimba S. Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation of Socs3 Gene Expression. J. Biol. Chem. 2016 291:7004-16 PubMed ID: 26865635

9569 Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine 2016 23:417-28 PubMed ID: 27002412

9607 Sugiyama K, Muroi M, Kinoshita M, Hamada O, Minai Y, Sugita-Konishi Y, Kamata Y, Tanamoto K. NF-κB activation via MyD88-dependent Toll-like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol. J Toxicol Sci 2016 41:273-9 PubMed ID: 26961612

9609 Nakabayashi H, Aoyama S, Kawahara M, Nagamune T. Differentiation signalobody: Demonstration of antigen-dependent osteoclast differentiation from a progenitor cell line. J. Biosci. Bioeng. 2016 122:357-63 PubMed ID: 26979343

9612 Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J. Cell. Physiol. 2016 231:2761-7 PubMed ID: 26989816

9690 Elfeky M, Kaede R, Okamatsu-Ogura Y, Kimura K. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators Inflamm. 2016 2016:5701959 PubMed ID: 27313399

9692 Kure A, Nakagawa K, Kondo M, Kato S, Kimura F, Watanabe A, Shoji N, Hatanaka S, Tsushida T, Miyazawa T. Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect. J. Agric. Food Chem. 2016 64:4246-54 PubMed ID: 27170112

9706 Zhang J, Hiromoto S, Yamazaki T, Niu J, Huang H, Jia G, Li H, Ding W, Yuan G. Effect of macrophages on in vitro corrosion behavior of magnesium alloy. J Biomed Mater Res A 2016 104:2476-87 PubMed ID: 27223576

9740 Sunarso , Toita R, Tsuru K, Ishikawa K. A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses. J Mater Sci Mater Med 2016 27:127 PubMed ID: 27344451

9747 Arikawa M, Kakinuma Y, Noguchi T, Todaka H, Sato T. Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation. Eur. J. Pharmacol. 2016 789:17-26 PubMed ID: 27373848

9818 Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, Katsumata Y, Makihira S, Kawai T, Taubman MA, Nakamura Y. A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. Sci Rep 2016 6:32259 PubMed ID: 27573075

9882 Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep 2016 6:35930 PubMed ID: 27775020

9922 Yamawaki T, Ito E, Mukai A, Ueno M, Yamada J, Sotozono C, Kinoshita S, Hamuro J. The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells. Invest. Ophthalmol. Vis. Sci. 2016 57:5945-5953 PubMed ID: 27820950

9969 Domon H, Oda M, Maekawa T, Nagai K, Takeda W, Terao Y. Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. Sci Rep 2016 6:38013 PubMed ID: 27892542

10852 Kejuan Li, Xi Yang, Xuansheng Hu, Chao Han, Zhongfang Lei, Zhenya Zhang In vitro antioxidant, immunomodulatory and anticancer activities of two fractions of aqueous extract from Helicteres angustifolia L. root Journal of the Taiwan Institute of Chemical Engineers 2016 61:75-82

10857 Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients Journal of Cosmetics, Dermatological Sciences and Applications 2016 6, 9-18

10869 Isolation and Biochemical Characterization of Mucus Proteins in Japanese Bunching Onion (Allium fistulosum) Green Leaves Food Science and Technology Research 2016 22

10109 Yusuke Kono, Ayu Iwasaki, Kenta Matsuoka, Takuya Fujita Effect of Mechanical Agitation on Cationic Liposome Transport Across an Unstirred Water Layer in Caco-2 Cells Biol Pharm Bull 2016 39(8):1293-9 PubMed ID: 27476939

7119 Taniguchi M, Ochiai A, Matsushima K, Tajima K, Kato T, Saitoh E, Tanaka T. Endotoxin-neutralizing activity and mechanism of action of a cationic α-helical antimicrobial octadecapeptide derived from α-amylase of rice. Peptides 2015 75:101-8 PubMed ID: 26643956

7137 Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K. Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo. Sci Rep 2015 5:17205 PubMed ID: 26598133

7148 Ohta T, Kusano K, Ido A, Miura C, Miura T. Silkrose: A novel acidic polysaccharide from the silkmoth that can stimulate the innate immune response. Carbohydr Polym 2015 136:995-1001 PubMed ID: 26572439

7157 Higuchi H, Shoji T, Murase Y, Iijima S, Nishijima K. Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Biosci. Biotechnol. Biochem. 2015 80:501-9 PubMed ID: 26540411

7221 Sawada Y, Sakamoto Y, Toh M, Ohara N, Hatanaka Y, Naka A, Kishimoto Y, Kondo K, Iida K. Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade. Mol Nutr Food Res 2015 59:2502-10 PubMed ID: 26346532

7230 Takayama S, Hashimoto K, Kokubu E, Taniguchi M, Tajima K, Ochiai A, Saitoh E, Saito A, Ishihara K, Kato T. Inhibitory effects of a novel cationic dodecapeptide [CL(14-25)] derived from cyanate lyase of rice on endotoxic activities of LPSs from Escherichia coli and periodontopathic Aggregatibacter actinomycetemcomitans. Microb. Pathog. 2015 94:2-11 PubMed ID: 26318142

7274 Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K. IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. J. Clin. Invest. 2015 125:3269-79 PubMed ID: 26193638

7293 Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y. Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages. Endocrinology 2015 156:3680-94 PubMed ID: 26132918

7321 Hashimoto M, Sasaki JI, Yamaguchi S, Kawai K, Kawakami H, Iwasaki Y, Imazato S. Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity. J. Dent. Res. 2015 94:1085-91 PubMed ID: 26040283

7340 Suzuki N, Takimoto K, Kawashima N. Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions. J Endod 2015 41:1474-9 PubMed ID: 25990199

7420 Miyazaki T, Miyauchi S, Anada T, Tawada A, Suzuki O. Chondroitin Sulfate-E Binds to Both Osteoactivin and Integrin αVβ3 and Inhibits Osteoclast Differentiation. J. Cell. Biochem. 2015 116:2247-57 PubMed ID: 25820496

7448 Takeuchi T, Shimakawa G, Tamura M, Yokosawa H, Arata Y. ISG15 regulates RANKL-induced osteoclastogenic differentiation of RAW264 cells. Biol. Pharm. Bull. 2015 38:482-6 PubMed ID: 25757932

7451 Hashimoto M, Imazato S. Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages. Dent Mater 2015 31:556-64 PubMed ID: 25749564

7467 Kawabata K, Kato Y, Sakano T, Baba N, Hagiwara K, Tamura A, Baba S, Natsume M, Ohigashi H. Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis. Biosci. Biotechnol. Biochem. 2015 79:799-807 PubMed ID: 25721815

7469 Hashimoto M, Sasaki J, Imazato S. Investigation of the cytotoxicity of aluminum oxide nanoparticles and nanowires and their localization in L929 fibroblasts and RAW264 macrophages. J. Biomed. Mater. Res. Part B Appl. Biomater. 2015 104:241-52 PubMed ID: 25715832

7492 Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M. Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury. Am. J. Physiol. Renal Physiol. 2015 308:F878-87 PubMed ID: 25656369

7505 Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages. Biosci. Biotechnol. Biochem. 2015 79:82-7 PubMed ID: 25603813

7517 Taniguchi M, Ochiai A, Takahashi K, Nakamichi S, Nomoto T, Saitoh E, Kato T, Tanaka T. Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice. Biopolymers 2015 104:73-83 PubMed ID: 25581614

7526 F Shima, T Akagi, M Shudo, E Mochizuki, T Tsuda, S Kuwabata M Akashi Interaction between living cells and polymeric particles: potential application of ionic liquid for evaluating the cellular uptake of biodegradable polymeric particles composed of poly(amino acid). Polymer Journal 2015 47:631-638

6343 Uto T, Tung NH, Taniyama R, Miyanowaki T, Morinaga O, Shoyama Y. Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa. Phytother Res 2015 29(12):1956-63 PubMed ID: 26463105

10173 Yao-Tong Lai, Seiichi Ohta, Kazuki Akamatsu, Shin-Ichi Nakao, Yasuyuki Sakai, Taichi Ito Size-dependent Interaction of Cells and Hemoglobin-Albumin Based Oxygen Carriers Prepared Using the SPG Membrane Emulsification Technique Biotechnol Prog . 2015 31(6):1676-84 PubMed ID: 26399378

10195 Akihiko Nagao, Takashi Maoka, Hiroshi Ono, Eiichi Kotake-Nara, Miyuki Kobayashi, Mie Tomita A 3-hydroxy β-End Group in Xanthophylls Is Preferentially Oxidized to a 3-oxo ε-End Group in Mammals J Lipid Res 2015 56(2):449-62 PubMed ID: 25502844

6334 Itoh T, Tsuchida A, Muramatsu Y, Ninomiya M, Ando M, Tsukamasa Y, Koketsu M. Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes. Anaerobe 2014 27:56-63 PubMed ID: 24699048

2777 Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, Sakurai K, Nishihara T. The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. J Biol Chem 2014 289(27):19191-203 PubMed ID: 24821724

6607 Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y. Constitutive and functional expression of runt-related transcription factor-2 by microglial cells. Neurochem Int 2014 74:24-35 PubMed ID: 24768841

9114 Erdenezaya Odkhuu, Takayuki Komatsu, Yoshikazu Naiki, Naoki Koide, Takashi Yokochi Sendai Virus C Protein Inhibits Lipopolysaccharide-Induced Nitric Oxide Production Through Impairing Interferon-β Signaling Int Immunopharmacol 2014 23 (1), 267-72 PubMed ID: 25242386

9323 Ran Zhao, Masayoshi Kamon, Kazuichi Sakamoto (–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell Food and Nutrition Sciences 2014 5, Article ID:41962

9349 Masanori Hashimoto, Hirokazu Toshima, Tetsu Yonezawa, Koji Kawai, Takashi Narushima, Masayuki Kaga, Kazuhiko Endo Responses of RAW264.7 Macrophages to Water-Dispersible Gold and Silver Nanoparticles Stabilized by Metal-Carbon σ-Bonds J Biomed Mater Res A 2014 102(6):1838-49 PubMed ID: 23784947

9351 Miki Tadaishi, Yoriko Nishide, Yuko Tousen, Marlena C Kruger, Yoshiko Ishimi Cooperative Effects of Soy Isoflavones and Carotenoids on Osteoclast Formation J Clin Biochem Nutr 2014 54(2):109-15 PubMed ID: 24688220

7584 T. Atsumi, A. Iwashita, I. Ohtsuka, N. Kakiuchi, Y. Sasaki, M. Mikage, K. Toriizuka Effects of Atractylodis Lanceae Rhizoma on in?ammatory mediator production from the RAW264 macrophage cell line. J Traditional Medicines 2013 30:124-131

5424 Takeshi KAWAHARA, Daichi NAKAYAMA, Keisuke TODA, Shyuichiro INAGAKI, Katsumi TANAKA, Hisako YASUI Suppressive Effect of Wild Saccharomyces cerevisiae and Saccharomyces paradoxus Strains on Ige Production by Mouse Spleen Cells Food Sci. Technol. Res 2013 19 (6), 1019 – 1027

6086 Ito S, Tanaka Y, Nishio N, Thanasegaran S, Isobe K. Establishment of self-renewable GM-CSF-dependent immature macrophages in vitro from murine bone marrow. PLoS One 2013 8(10):e76943 PubMed ID: 24124601

6326 Horibe K, Nakamichi Y, Uehara S, Nakamura M, Koide M, Kobayashi Y, Takahashi N, Udagawa N. Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis. Immunology 2013 140(3):344-51 PubMed ID: 23826736

6466 Etoh T, Kim YP, Ohsaki A, Komiyama K, Hayashi M. Inhibitory effect of erythraline on Toll-like receptor signaling pathway in RAW264.7 cells. Biol Pharm Bull 2013 36(8):1363-9 PubMed ID: 23902980

6467 Etoh T, Kim YP, Tanaka H, Hayashi M. Anti-inflammatory effect of berkeleyacetal C through the inhibition of interleukin-1 receptor-associated kinase-4 activity. Eur J Pharmacol 2013 698(1-3):435-43 PubMed ID: 23127497

9096 Kyoko Ueda, Ryoko Kawabata, Takashi Irie, Yoshiaki Nakai, Yukinobu Tohya, Takemasa Sakaguchi Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts From Persimmon (Diospyros Kaki) on a Broad Range of Viruses PLoS One 2013 8 (1), e55343 PubMed ID: 23372851

9100 Hiroki Ishikawa, Naoki Awano, Toshie Fukui, Hiraku Sasaki, Shigeru Kyuwa The Protective Effects of Lactoferrin Against Murine Norovirus Infection Through Inhibition of Both Viral Attachment and Replication Biochem Biophys Res Commun 2013 434 (4), 791-6 PubMed ID: 23603257

9169 Akari Ishisaka, Kyuichi Kawabata, Satomi Miki, Yuko Shiba, Shoko Minekawa, Tomomi Nishikawa, Rie Mukai, Junji Terao, Yoshichika Kawai Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages PLoS One 2013 8 (11), e80843 PubMed ID: 24260490

9256 Masanori Hashimoto, Hirokazu Toshima, Tetsu Yonezawa, Koji Kawai, Takashi Narushima, Masayuki Kaga, Kazuhiko Endo Micromorphological Cellular Responses of MC3T3-E1 and RAW264.7 After Exposure to Water-Dispersible Silver Nanoparticles Stabilized by Metal-Carbon σ-Bonds Dent Mater J 2013 32(5):725-33 PubMed ID: 24088827

9290 Hirohiko Okamura, Di Yang, Kaya Yoshida, Tatsuji Haneji Protein Phosphatase 2A Cα Is Involved in Osteoclastogenesis by Regulating RANKL and OPG Expression in Osteoblasts FEBS Lett 2013 587(1):48-53 PubMed ID: 23183242

7589 Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, Todo S. A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. J Crohns Colitis 2012 6:215-25 PubMed ID: 22325176

4881 Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol 2012 91(6):967-76 PubMed ID: 22422925

5417 Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung UI, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med 2012 10:80 PubMed ID: 22546323

6552 Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y, Hinoi E, Yoneda Y. Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts. J Cell Physiol 2012 227(10):3477-87 PubMed ID: 22252936

9092 Hiroyasu Tsutsuki, Kinnosuke Yahiro, Kotaro Suzuki, Akira Suto, Kohei Ogura, Sayaka Nagasawa, Hideshi Ihara, Takeshi Shimizu, Hiroshi Nakajima, Joel Moss, Masatoshi Noda Subtilase Cytotoxin Enhances Escherichia Coli Survival in Macrophages by Suppression of Nitric Oxide Production Through the Inhibition of NF-κB Activation Infect Immun 2012 80 (11), 3939-51 PubMed ID: 22949549

7599 Takano K, Sato K, Negishi Y, Aramaki Y. Involvement of actin cytoskeleton in macrophage apoptosis induced by cationic liposomes. Arch. Biochem. Biophys. 2011 518:89-94 PubMed ID: 22203089

7608 Takahashi K, Sugiyama T, Tokoro S, Neri P, Mori H. Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction. Cell. Immunol. 2011 273:73-8 PubMed ID: 22177846

7609 Uto T, Morinaga O, Tanaka H, Shoyama Y. Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract. Biochem. Biophys. Res. Commun. 2011 417:473-8 PubMed ID: 22178686

7621 Nakagawa S, Arai Y, Kishida T, Hiraoka N, Tsuchida S, Inoue H, Sakai R, Mazda O, Kubo T. Lansoprazole inhibits nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells. Inflammation 2011 35:1062-8 PubMed ID: 22134422

7633 Yamamoto H, Abe Y, Miyazato A, Tanno D, Tanaka M, Miyasaka T, Ishii K, Kawakami K. Cryptococcus neoformans suppresses the activation of bone marrow-derived dendritic cells stimulated with its own DNA, but not with DNA from other fungi. FEMS Immunol. Med. Microbiol. 2011 63:363-72 PubMed ID: 22092563

7639 Uto T, Qin GW, Morinaga O, Shoyama Y. 17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages. Int. Immunopharmacol. 2011 12:101-9 PubMed ID: 22080918

7667 Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H. Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice. J Physiol Sci 2011 62:59-62 PubMed ID: 21968540

7678 Sugiyama T, Takahashi K, Tokoro S, Gotou T, Neri P, Mori H. Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression. Innate Immun 2011 18:429-37 PubMed ID: 21948282

7702 Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M, Hou DX. A genome-wide microarray highlights the antiinflammatory genes targeted by oolong tea theasinensin A in macrophages. Nutr Cancer 2011 63:1064-73 PubMed ID: 21864060

7725 Sakamoto T, Yamaguchi Y, Goto T, Takahashi N, Kawada T. An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages. Biosci. Biotechnol. Biochem. 2011 75:1582-7 PubMed ID: 21821941

7745 Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M. Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem. Biophys. Res. Commun. 2011 411:143-9 PubMed ID: 21723254

7750 Fujimoto A, Akifusa S, Hirofuji T, Yamashita Y. Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell. Mol. Immunol. 2011 48:2052-8 PubMed ID: 21764457

7789 Abiko Y, Miura T, Phuc BH, Shinkai Y, Kumagai Y. Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole. Toxicol. Appl. Pharmacol. 2011 255:32-9 PubMed ID: 21651925

7794 Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T. An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunol. Immunother. 2011 60:1439-46 PubMed ID: 21644032

7850 Egusa H, Doi M, Saeki M, Fukuyasu S, Akashi Y, Yokota Y, Yatani H, Kamisaki Y. The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells. Bone 2011 49:264-74 PubMed ID: 21504804

7851 Akagi T, Shima F, Akashi M. Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles. Biomaterials 2011 32:4959-67 PubMed ID: 21482432

7901 Yamazaki Y, Kawano Y. Inhibitory effects of herbal alkaloids on the tumor necrosis factor-α and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages. Chem. Pharm. Bull. 2011 59:388-91 PubMed ID: 21372424

7921 Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Exp. Cell Res. 2011 317:1134-46 PubMed ID: 21338601

7949 Arisaka M, Takano K, Negishi Y, Arima H, Aramaki Y. Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes. Arch. Biochem. Biophys. 2011 508:72-7 PubMed ID: 21315683

7966 Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 2011 60:819-26 PubMed ID: 21282371

8010 Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol. Immunol. 2011 55:160-7 PubMed ID: 21204955

8050 Hou DX, Masuzaki S, Tanigawa S, Hashimoto F, Chen J, Sogo T, Fujii M. Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: structure-activity relationship and molecular mechanisms. J. Agric. Food Chem. 2010 58:12735-43 PubMed ID: 21082860

8052 Miyazaki T, Miyauchi S, Anada T, Imaizumi H, Suzuki O. Evaluation of osteoclastic resorption activity using calcium phosphate coating combined with labeled polyanion. Anal. Biochem. 2010 410:7-12 PubMed ID: 21078287

8058 Oshima H, Hioki K, Popivanova BK, Oguma K, Van Rooijen N, Ishikawa TO, Oshima M. Prostaglandin E? signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology 2010 140:596-607.e7 PubMed ID: 21070778

8060 Ueda H, Ippoushi K, Takeuchi A. Repeated oral administration of a squeezed ginger (Zingiber officinale) extract augmented the serum corticosterone level and had anti-inflammatory properties. Biosci. Biotechnol. Biochem. 2010 74:2248-52 PubMed ID: 21071834

8066 Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT. Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo. Eur. J. Pharmacol. 2010 650:511-8 PubMed ID: 21047508

8067 Kamio N, Akifusa S, Yamashita Y. Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species. Free Radic. Res. 2010 45:336-41 PubMed ID: 21034360

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

8102 Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells. Biol. Pharm. Bull. 2010 33:1733-9 PubMed ID: 20930384

8113 Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol. Cancer Ther. 2010 9:2960-9 PubMed ID: 20858724

8135 Fukata N, Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukui T, Matsushita M, Nishio A, Tabata Y, Okazaki K. The effective therapy of cyclosporine A with drug delivery system in experimental colitis. J Drug Target 2010 19:458-67 PubMed ID: 20804404

8136 Shikama Y, Nagai Y, Okada S, Oizumi T, Shimauchi H, Sugawara S, Endo Y. Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate. Toxicol. Lett. 2010 199:123-8 PubMed ID: 20804833

8168 Yoshikawa K, Kokudo N, Hashimoto T, Yamamoto K, Inose T, Kimura T. Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity. Biol. Pharm. Bull. 2010 33:1355-9 PubMed ID: 20686231

8181 Nakatsuka R, Nozaki T, Shinohara M, Ohura K. Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells. J. Pharmacol. Sci. 2010 113:271-5 PubMed ID: 20647687

8208 Yano H, Uchida M, Nakai R, Ishida K, Kato Y, Kawanishi N, Shiva D. Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice. Eur. J. Appl. Physiol. 2010 110:797-803 PubMed ID: 20602110

8210 Shadat NM, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53. Cancer Invest. 2010 28:806-12 PubMed ID: 20594067

8214 Sakai H, Moriura Y, Notomi T, Kawawaki J, Ohnishi K, Kuno M. Phospholipase C-dependent Ca2+-sensing pathways leading to endocytosis and inhibition of the plasma membrane vacuolar H+-ATPase in osteoclasts. Am. J. Physiol., Cell Physiol. 2010 299:C570-8 PubMed ID: 20592242

8221 Yasuzaki Y, Yamada Y, Harashima H. Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes. Biochem. Biophys. Res. Commun. 2010 397:181-6 PubMed ID: 20580633

8224 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nonaka K, Yamashita Y. Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells. J. Cell. Biochem. 2010 111:597-606 PubMed ID: 20564237

8228 Kato Y, Koide N, Komatsu T, Tumurkhuu G, Dagvadorj J, Kato K, Yokochi T. Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway. Horm. Metab. Res. 2010 42:632-6 PubMed ID: 20560107

8229 Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation. Cell. Immunol. 2010 264:114-8 PubMed ID: 20557878

8249 Ohata S, Moriyama C, Yamashita A, Nishida T, Kusumoto C, Mochida S, Minami Y, Nakada J, Shomori K, Inagaki Y, Ohta Y, Matsura T. Polaprezinc Protects Mice against Endotoxin Shock. J Clin Biochem Nutr 2010 46:234-43 PubMed ID: 20490319

8258 Yamaguchi N, Hamachi T, Kamio N, Akifusa S, Masuda K, Nakamura Y, Nonaka K, Maeda K, Hanazawa S, Yamashita Y. Expression levels of adiponectin receptors and periodontitis. J. Periodont. Res. 2010 45:296-300 PubMed ID: 20470261

8273 Xiao G, Miyazato A, Abe Y, Zhang T, Nakamura K, Inden K, Tanaka M, Tanno D, Miyasaka T, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Yamamoto N, Kunishima H, Hirakata Y, Kaku M, Kawakami K. Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell. Immunol. 2010 263:241-50 PubMed ID: 20451901

8282 Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression. Immunol. Lett. 2010 131:166-9 PubMed ID: 20417662

8286 Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. Immunology 2010 131:59-66 PubMed ID: 20406300

8335 Kitagawa Y, Tohya Y, Ike F, Kajita A, Park SJ, Ishii Y, Kyuwa S, Yoshikawa Y. Indirect ELISA and indirect immunofluorescent antibody assay for detecting the antibody against murine norovirus S7 in mice. Exp. Anim. 2010 59:47-55 PubMed ID: 20224169

8359 Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology 2010 61:125-34 PubMed ID: 20162352

8368 Shimoda H, Shan SJ, Tanaka J, Seki A, Seo JW, Kasajima N, Tamura S, Ke Y, Murakami N. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J Med Food 2010 13:156-62 PubMed ID: 20136450

8369 Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int. Immunol. 2010 22:271-80 PubMed ID: 20133493

8372 Arisaka M, Nakamura T, Yamada A, Negishi Y, Aramaki Y. Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. FEBS Lett. 2010 584:1016-20 PubMed ID: 20122929

8373 Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, Uchikawa S, Takaishi H, Matsumoto M, Chiba K, Horiuchi K, Toyama Y. Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages. J. Immunol. 2010 184:2442-8 PubMed ID: 20118276

8396 Suzuki T, Chang MO, Kitajima M, Takaku H. Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses. Cell. Immunol. 2010 262:35-43 PubMed ID: 20060108

5872 Chen J, Uto T, Tanigawa S, Yamada-Kato T, Fujii M, Hou DX. Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl)hexyl isothiocyanate in macrophages. Exp Ther Med 2010 1(1):33-40 PubMed ID: 23136589

8268 Miyazaki T, Miyauchi S, Tawada A, Anada T, Suzuki O. Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells. Dent Mater J 2010 29(4):403-10 PubMed ID: 20610874

8415 Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun 2009 17:97-105 PubMed ID: 20023007

8426 Hirai S, Uemura T, Mizoguchi N, Lee JY, Taketani K, Nakano Y, Hoshino S, Tsuge N, Narukami T, Yu R, Takahashi N, Kawada T. Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Mol Nutr Food Res 2009 54:797-804 PubMed ID: 19998383

8455 Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada H, Sugawara S, Endo Y. Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). Innate Immun 2009 17:3-15 PubMed ID: 19897531

8462 Matsubara T, Ikeda F, Hata K, Nakanishi M, Okada M, Yasuda H, Nishimura R, Yoneda T. Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts. J. Bone Miner. Res. 2009 25:1068-76 PubMed ID: 19874196

8465 Sugiyama K, Muroi M, Tanamoto K, Nishijima M, Sugita-Konishi Y. Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. Toxicol. Lett. 2009 192:150-4 PubMed ID: 19857559

8488 Kishimoto Y, Tani M, Uto-Kondo H, Iizuka M, Saita E, Sone H, Kurata H, Kondo K. Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. Eur J Nutr 2009 49:119-26 PubMed ID: 19784539

8495 Katsuura S, Imamura T, Bando N, Yamanishi R. beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages. Mol Nutr Food Res 2009 53:1396-405 PubMed ID: 19760679

8549 Shioiri T, Muroi M, Hatao F, Nishida M, Ogawa T, Mimura Y, Seto Y, Kaminishi M, Tanamoto K. Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide. Biochim. Biophys. Acta 2009 1792:1011-8 PubMed ID: 19559790

8550 Kamio N, Akifusa S, Yamaguchi N, Nonaka K, Yamashita Y. Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomycetemcomitans. FEMS Immunol. Med. Microbiol. 2009 56:241-7 PubMed ID: 19552715

8551 Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice. FEMS Immunol. Med. Microbiol. 2009 56:204-11 PubMed ID: 19538513

8578 Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K. Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans. Infect. Immun. 2009 77:3056-64 PubMed ID: 19433551

8589 Seddek Al, Mahmoud ME, Shiina T, Hirayama H, Iwami M, Miyazawa S, Nikami H, Takewaki T, Shimizu Y. Extract from Calotropis procera latex activates murine macrophages. J Nat Med 2009 63:297-303 PubMed ID: 19399577

8637 Tomimori Y, Mori K, Koide M, Nakamichi Y, Ninomiya T, Udagawa N, Yasuda H. Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss. J. Bone Miner. Res. 2009 24:1194-205 PubMed ID: 19257825

8640 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nishihara T, Yamashita Y. Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2. Free Radic. Biol. Med. 2009 46:1308-16 PubMed ID: 19250964

8641 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Yamashita Y. Involvement of Ca(2+) in globular adiponectin-induced reactive oxygen species. Biochem. Biophys. Res. Commun. 2009 381:649-53 PubMed ID: 19249286

8642 Hassan F, Islam S, Tumurkhuu G, Dagvadorj J, Naiki Y, Komatsu T, Koide N, Yoshida T, Yokochi T. Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells. Cell. Immunol. 2009 256:99-103 PubMed ID: 19251253

8648 Kasugai C, Morikawa A, Naiki Y, Koide N, Komatsu T, Yoshida T, Yokochi T. Concanavalin A induces formation of osteoclast-like cells in RAW 264.7 mouse macrophage cells. Immunopharmacol Immunotoxicol 2009 31:103-7 PubMed ID: 19234958

8654 Iftakhar-E-Khuda I, Koide N, Hassan F, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Novel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells. Clin. Exp. Immunol. 2009 155:552-8 PubMed ID: 19220841

8663 Noman AS, Koide N, Hassan F, I-E-Khuda I, Dagvadorj J, Tumurkhuu G, Islam S, Naiki Y, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression. Innate Immun 2009 15:33-41 PubMed ID: 19201823

10145 Murakami M, Kawachi H, Ogawa K, Nishino Y, Funaba M. Receptor expression modulates the specificity of transforming growth factor-beta signaling pathways. Genes Cells 2009 14(4):469-82 PubMed ID: 19335617

8170 Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, Kato S, Terao J, Inakuma T, Takeda E. Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J Bone Miner Metab 2009 27(6):673-81 PubMed ID: 19495926

8691 Inden K, Kaneko J, Miyazato A, Yamamoto N, Mouri S, Shibuya Y, Nakamura K, Aoyagi T, Hatta M, Kunishima H, Hirakata Y, Itoh Y, Kaku M, Kawakami K. Toll-like receptor 4-dependent activation of myeloid dendritic cells by leukocidin of Staphylococcus aureus. Microbes Infect. 2008 11:245-53 PubMed ID: 19111627

8731 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Yamashita Y. Regulation of globular adiponectin-induced apoptosis by reactive oxygen/nitrogen species in RAW264 macrophages. Free Radic. Biol. Med. 2008 45:1326-39 PubMed ID: 18775488

8739 Nakamura T, Kodama N, Arai Y, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ishikawa T, Ueno K, Yano S. Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7. J Nat Med 2008 63:21-7 PubMed ID: 18636311

8740 Nakamura T, Kodama N, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ueno K, Ishikawa T, Yano S. Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7. J Nat Med 2008 63:107-10 PubMed ID: 18626726

8742 Nakamura T, Kodama N, Oda M, Tsuchiya S, Arai Y, Kumamoto T, Ishikawa T, Ueno K, Yano S. The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells. J Nat Med 2008 63:15-20 PubMed ID: 18607531

8754 Yoshida H, Kwon AH, Habara K, Yamada M, Kaibori M, Kamiyama Y, Nishizawa M, Ito S, Okumura T. Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages. Shock 2008 30:734-9 PubMed ID: 18496239

5375 Nishida K, Kuchiiwa S, Oiso S, Futagawa T, Masuda S, Takeda Y, Yamada K. Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. Cancer Sci 2008 99(8):1618-25 PubMed ID: 18754875

3578 Ando M, Tu W, Nishijima K, Iijima S. Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs. Biochem Biophys Res Commun 2008 369(3):878-83 PubMed ID: 18325328

6521 Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 2008 283(36):24682-9 PubMed ID: 18617520

8815 Taira M, Sasaki K, Saitoh S, Nezu T, Sasaki M, Kimura S, Terasaki K, Sera K, Narushima T, Araki Y. Accumulation of element Ti in macrophage-like RAW264 cells cultured in medium with 1 ppm Ti and effects on cell viability, SOD production and TNF-alpha secretion. Dent Mater J 2007 25:726-32 PubMed ID: 17338307

4889 Takayoshi Suganami, Kanami Tanimoto-Koyama, Junko Nishida, Michiko Itoh, Xunmei Yuan, Shinji Mizuarai, Hidehito Kotani, Shoji Yamaoka, Kensuke Miyake, Seiichiro Aoe, Yasutomi Kamei and Yoshihiro Ogawa Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid−Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages Arterioscler Thromb Vasc Biol 2007 27:84-91 PubMed ID: 17082484

7269 Takarada T, Hinoi E, Kambe Y, Sahara K, Kurokawa S, Takahata Y, Yoneda Y. Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid. Eur J Pharmacol 2007 575(1-3):1-11 PubMed ID: 17698058

7349 Ito M, Haito S, Furumoto M, Uehata Y, Sakurai A, Segawa H, Tatsumi S, Kuwahata M, Miyamoto K. Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells. Am J Physiol Cell Physiol 2007 292(1):C526-34 PubMed ID: 16971494

7387 Murakami Y, Hirata A, Ito S, Shoji M, Tanaka S, Yasui T, Machino M, Fujisawa S. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res 2007 27(2):801-7 PubMed ID: 17465205

8850 Yamaguchi N, Kukita T, Li YJ, Martinez Argueta JG, Saito T, Hanazawa S, Yamashita Y. Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol. Med. Microbiol. 2006 49:28-34 PubMed ID: 17094790

8917 Soji Fukumoto, Paramasari Dirgahayu, Kozue Nunomura, Haruyo Matsuura andKazumitsu Hirai Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids Yonago Acta Med. 2006 49:39-47

6489 Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther 2006 8(5):R146 PubMed ID: 16945157

7020 Murakami Y, Shoji M, Ogiwara T, Tanaka S, Yokoe I, Fujisawa S. Preventive effect of ortho dimer of butylated hydroxyanisole on activator protein-1 activation and cyclooxygenase-2 expression in macrophages stimulated by fimbriae of Porphyromonas gingivalis, an oral anaerobe. Anticancer Res 2006 26(4B):2915-20 PubMed ID: 16886613

7039 Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H. Requirement of Smad3 for mast cell growth. Cell Immunol 2006 240(1):47-52 PubMed ID: 16839529

3160 Wei, Ping, Taniguchi, Susumu, Sakai, Yoshiyuki, Imamura, Minako, Inoguchi, Toyoshi, Nawata, Hajime, Oda, Shinya, Nakabeppu, Yusaku, Nishimura, Junji, Ikuyama, Shoichiro Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages. J Biochem 2005 138:399-412 PubMed ID: 16272134

2903 Shimomura-Shimizu M, Sugiyama K, Muroi M, Tanamoto K Alachlor and carbaryl suppress lipopolysaccharide-induced iNOS expression by differentially inhibiting NF-kappaB activation. Biochem Biophys Res Commun 2005 332:793-9 PubMed ID: 15907790

2922 Musikacharoen, Tipayaratn, Oguma, Asako, Yoshikai, Yasunobu, Chiba, Norika, Masuda, Akio, Matsuguchi, Tetsuya Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling. Blood 2005 105:711-20 PubMed ID: 15345588

3365 Ito, Mikiko, Matsuka, Naoko, Izuka, Michiyo, Haito, Sakiko, Sakai, Yuko, Nakamura, Rie, Segawa, Hiroko, Kuwahata, Masashi, Yamamoto, Hironori, Pike, Wesley J, Miyamoto, Ken-ichi Characterization of inorganic phosphate transport in osteoclast-like cells. Am J Physiol Cell Physiol 2005 288:C921-31 PubMed ID: 15601753

3392 Aki, Daisuke, Mashima, Ryuichi, Saeki, Kazuko, Minoda, Yasumasa, Yamauchi, Moriyasu, Yoshimura, Akihiko Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages. Genes Cells 2005 10:357-68 PubMed ID: 15773898

3232 Arakawa, Reijiro, Tamehiro, Norimasa, Nishimaki-Mogami, Tomoko, Ueda, Kazumitsu, Yokoyama, Shinji Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol 2005 25:1193-7 PubMed ID: 15790930

3210 Hou, De-Xing, Yanagita, Takashi, Uto, Takuhiro, Masuzaki, Satoko, Fujii, Makoto Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem Pharmacol 2005 70:417-25 PubMed ID: 15963474

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