CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0535 : RAW 264]

18313 Kyogoku K, Yoshida K, Watanabe H, Yamashita T, Kawabe Y, Motono M, Nishijima K, Kamihira M, Iijima S. Production of recombinant tumor necrosis factor receptor/Fc fusion protein by genetically manipulated chickens J Biosci Bioeng 2008 105(5):454-9 PubMed ID: 18558334 DOI: 10.1263/jbb.105.454

262 Ralph P, Ito M, Broxmeyer HE, Nakoinz I. Corticosteroids block newly induced but not constitutive functions of macrophage cell lines: myeloid colony-stimulating activity production, latex phagocytosis, and antibody-dependent lysis of RBC and tumor targets J Immunol 1978 121(1):300-3 PubMed ID: 670703

34 Raschke WC, Baird S, Ralph P, Nakoinz I. Functional macrophage cell lines transformed by Abelson leukemia virus Cell 1978 15(1):261-7 PubMed ID: 212198 DOI: 10.1016/0092-8674(78)90101-0

716 Ralph P, Nakoinz I Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS. J Immunol 1977 119:950-54 PubMed ID: 894031

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17750 Kitazawa S, Haraguchi R, Takaoka Y, Kitazawa R. In situ sequence-specific visualization of single methylated cytosine on tissue sections using ICON probe and rolling-circle amplification Histochem Cell Biol 2023 159(3):263-273 PubMed ID: 36418613 DOI: 10.1007/s00418-022-02165-2

17768 Azumi J, Takeda T, Shimada Y, Zhuang T, Tokuji Y, Sakamoto N, Aso H, Nakamura T. Organogermanium THGP Induces Differentiation into M1 Macrophages and Suppresses the Proliferation of Melanoma Cells via Phagocytosis Int J Mol Sci 2023 24(3):1885 PubMed ID: 36768216 DOI: 10.3390/ijms24031885

17770 Yao D, Guo J, Qin T, Chen H, Jin S. Effect of Alleviating Fibrosis with EGCG-Modified Bone Graft in Murine Model Depended on Less Accumulation of Inflammatory Macrophage Biomed Res Int 2023 2023:9466110 PubMed ID: 36820222 DOI: 10.1155/2023/9466110

17779 Sansawat, A., Ratanacoon, M. and Nitteranon, V. Antioxidative, anti-inflammatory, antibacterial, and anti- adhesive activities of different solvent extracts from various parts of Basella rubra L. International Journal of Agricultural Technology 2023 19(2):655-668

21032 Do KM, Kodama T, Nguyen HM, Ikumi N, Soeda C, Shiokawa KI, Morita H. Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities. Phytochemistry 2023 205:113510 PubMed ID: 36379318 DOI: 10.1016/j.phytochem.2022.113510

21098 Tanikawa T, Kitamura M, Hayashi Y, Tomida N, Uwaya A, Isami F, Yokogawa T, Inoue Y. Anti-inflammatory Effect of a Combination of Cannabidiol and Morinda citrifolia Extract on Lipopolysaccharide-stimulated RAW264 Macrophages. In Vivo 2023 37(2):591-595 PubMed ID: 36881078 DOI: 10.21873/invivo.13117

21126 Ueda K, Ma C, Izumiya M, Kuroda C, Ishida H, Uemura T, Saito N, Aoki K, Haniu H. Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues. Nanomaterials (Basel) 2023 13(2) PubMed ID: 36677997 DOI: 10.3390/nano13020244

21152 Fukuta T, Ikeda-Imafuku M, Kodama S, Kuse J, Matsui K, Iwao Y. One-Step Pharmaceutical Preparation of PEG-Modified Exosomes Encapsulating Anti-Cancer Drugs by a High-Pressure Homogenization Technique. Pharmaceuticals (Basel) 2023 16(1) PubMed ID: 36678605 DOI: 10.3390/ph16010108

21155 Arimura N, Watanabe H, Kato H, Imafuku T, Nakano T, Sueyoshi M, Chikamatsu M, Tokumaru K, Nagasaki T, Maeda H, Tanaka M, Matsushita K, Maruyama T. Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation. Toxins (Basel) 2023 15(3) PubMed ID: 36977070 DOI: 10.3390/toxins15030179

21161 Amang À Ngnoung GA, Sidjui LS, Leutcha PB, Nganso Ditchou YO, Tchokouaha LRY, Herbette G, Baghdikian B, Kowa TK, Soh D, Kemzeu R, Poka M, Demana PH, Siwe Noundou X, Tchinda AT, Fekam Boyom F, Lannang AM, Nyassé B. Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae). Molecules 2023 28(6) PubMed ID: 36985700 DOI: 10.3390/molecules28062730

21180 Uchiyama H, Muramatsu D, Higashi H, Kida H, Iwai A. Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells. PLoS One 2023 18(4):e0284343 PubMed ID: 37053208 DOI: 10.1371/journal.pone.0284343

21191 Hirano-Kusuda M, Setoguchi S, Koga M, Goto S, Yamada A, Watase D, Nagata-Akaho N, Karube Y, Matsunaga K, Takata J. Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption. Pharm Res 2023 PubMed ID: 37081301 DOI: 10.1007/s11095-023-03500-5

21207 Takahashi S, Ferdousi F, Yamamoto S, Hirano A, Nukaga S, Nozaki H, Isoda H. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells. Int J Mol Sci 2023 24(7) PubMed ID: 37047640 DOI: 10.3390/ijms24076666

21213 Murata T, Jamsransuren D, Matsuda S, Ogawa H, Takeda Y. Rapid Virucidal Activity of Japanese Saxifraga Species-Derived Condensed Tannins against SARS-CoV-2, Influenza A Virus, and Human Norovirus Surrogate Viruses. Appl Environ Microbiol 2023 e0023723 PubMed ID: 37184410 DOI: 10.1128/aem.00237-23

21244 Kato M, Yamaguchi M, Ooka A, Takahashi R, Suzuki T, Onoda K, Yoshikawa Y, Tsunematsu Y, Sato M, Yoshioka Y, Igarashi M, Hayakawa S, Shoji K, Shoji Y, Ishikawa T, Watanabe K, Miyoshi N. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice. Sci Rep 2023 13(1):8924 PubMed ID: 37264108 DOI: 10.1038/s41598-023-36091-7

21268 Nakamura Y, Matsumoto H, Wu CH, Fukaya D, Uni R, Hirakawa Y, Katagiri M, Yamada S, Ko T, Nomura S, Wada Y, Komuro I, Nangaku M, Inagi R, Inoue T. Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection. Commun Biol 2023 6(1):666 PubMed ID: 37353597 DOI: 10.1038/s42003-023-05051-2

21282 Ishizaka T, Horiuchi K, Kondo S, Isaji M, Nakagawa T, Inoue M, Rikitake H, Taguchi E, Susa M, Yoda M, Ono T, Kozai Y, Chiba K. Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice. Bone Rep 2023 18:101693 PubMed ID: 37305428 DOI: 10.1016/j.bonr.2023.101693

21306 Kotaro Sakamoto, Wararat Kittikulsuth, Eijiro Miyako, Akumwami Steeve, Rika Ishimura, Shinsaku Nakagawa, Yukio Ago, Akira Nishiyama The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody PLoS ONE 2023 5;18(7):e0286651 PubMed ID: 37405999 DOI: 10.1371/journal.pone.0286651

21351 Yasuda K, Maeda H, Kinoshita R, Minayoshi Y, Mizuta Y, Nakamura Y, Imoto S, Nishi K, Yamasaki K, Sakuragi M, Nakamura T, Ikeda-Imafuku M, Iwao Y, Ishima Y, Ishida T, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis. ACS Nano 2023 PubMed ID: 37579503 DOI: 10.1021/acsnano.3c02877

21365 Togami K, Zhan X, Ishizawa K, Miyakoshi K, Miyao A, Quan P, Chono S. Development of LOX-1 Antibody Modified Immuno-liposomes as Drug Carriers to Macrophages in Atherosclerotic Lesions. Pharmazie 2023 78(8):113-116 PubMed ID: 37592420 DOI: 10.1691/ph.2023.3004

21487 Tsuchiya A, Suzuki M, Ryotaro I, Batubara I, Yamauchi K, Mitsunaga T. New flavan trimer from Daemonorops draco as osteoclastogenesis inhibitor. Fitoterapia 2023 105757 PubMed ID: 38008129 DOI: 10.1016/j.fitote.2023.105757

17548 Synthesis of a Dual-Color Fluorescent Dendrimer for Diagnosis of Cancer Metastasis in Lymph Nodes. Synthesis of a Dual-Color Fluorescent Dendrimer for Diagnosis of Cancer Metastasis in Lymph Nodes Polymers (Basel) 2022 14(20):4314 PubMed ID: 36297891 DOI: 10.3390/polym14204314

17561 Shan Q, Takabatake K, Kawai H, Oo MW, Sukegawa S, Fujii M, Nakano K, Nagatsuka H. Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor‑associated macrophages into the tumor microenvironment of oral squamous cell carcinoma Int J Oncol 2022 60(6):78 PubMed ID: 35514301 DOI: 10.3892/ijo.2022.5368

17568 Wang D, Nagata M, Matsumoto M, Amen Y, Wang D, Shimizu K. Potential of Hibiscus sabdariffa L. and Hibiscus Acid to Reverse Skin Aging Molecules 2022 27(18):6076 PubMed ID: 36144809 DOI: 10.3390/molecules27186076

17593 Mamta Kumawat, Harishkumar Madhyastha, Mandeep Singh, Devendra Jain, Hemant Kumar Daima Functional silver nanozymes regulate cell inflammatory cytokines expression in mouse macrophages Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022 650:129294 DOI: 10.1016/j.colsurfa.2022.129294

17603 Saiki P, Yoshihara M, Kawano Y, Miyazaki H, Miyazaki K. Anti-Inflammatory Effects of Heliangin from Jerusalem Artichoke ( Helianthus tuberosus) Leaves Might Prevent Atherosclerosis Biomolecules 2022 12(1):91 PubMed ID: 35053238 DOI: 10.3390/biom12010091

17621 Nagase K, Kojima N, Goto M, Akaike T, Kanazawa H. Thermoresponsive block copolymer brush for temperature-modulated hepatocyte separation J Mater Chem B 2022 10(42):8629-8641 PubMed ID: 35972447 DOI: 10.1039/d2tb01384c

17641 Suzuki Y, Kikuchi T, Goto H, Takayanagi Y, Kawamura S, Sawada N, Naiki Y, Kondo H, Hayashi JI, Hasegawa Y, Mitani A. Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells Int J Mol Sci 2022 23(23):15293 PubMed ID: 36499621 DOI: 10.3390/ijms232315293

17685 Fang K, Murakami Y, Kanda S, Shimono T, Dang AT, Ono M, Nishiyama T. Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1-Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis Int J Mol Sci 2022 23(14):7814 PubMed ID: 35887169 DOI: 10.3390/ijms23147814

17693 Agista AZ, Tanuseputero SA, Koseki T, Ardiansyah, Budijanto S, Sultana H, Ohsaki Y, Yeh CL, Yang SC, Komai M, Shirakawa H. Tryptamine, a Microbial Metabolite in Fermented Rice Bran Suppressed Lipopolysaccharide-Induced Inflammation in a Murine Macrophage Model Int J Mol Sci 2022 23(19):11209 PubMed ID: 36232510 DOI: 10.3390/ijms231911209

17749 Saito M, Watanabe H, Sasaki M, Ookubo M, Yarita T, Shiraiwa M, Asayama M. Coproduction of lipids and carotenoids by the novel green alga Coelastrella sp. depending on cultivation conditions Biotechnol Rep (Amst) 2022 e00769 PubMed ID: 36660172 DOI: 10.1016/j.btre.2022.e00769

18219 Shiba H, Nishio M, Sawada M, Tamaki M, Michigami M, Nakai S, Nakase I, Fujii I, Matsumoto A, Kojima C. Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells J Mater Chem B 2022 10(14):2463-2470 PubMed ID: 34935852 DOI: 10.1039/d1tb01980e

20345 Thein HSS, Hashimoto K, Kawashima N, Noda S, Okiji T. Evaluation of the anti-inflammatory effects of surface-reaction-type pre-reacted glass-ionomer filler containing root canal sealer in lipopolysaccharide-stimulated RAW264.7 macrophages. Dent Mater J 2022 PubMed ID: 34602587 DOI: 10.4012/dmj.2021-139

20526 Aki T, Funakoshi T, Unuma K, Uemura K. Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis 2022 PubMed ID: 35006493 DOI: 10.1007/s10495-022-01708-1

20542 Do KM, Kodama T, Shin MK, Nu LHT, Nguyen HM, Dang SV, Shiokawa KI, Hayakawa Y, Morita H. Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities. Phytochemistry 2022 196:113109 PubMed ID: 35091214 DOI: 10.1016/j.phytochem.2022.113109

16213 Jing‐Yi Xue, Giedre Grigelioniene, Zheng Wang, Gen Nishimura, Aritoshi Iida, Naomichi Matsumoto, Emma Tham, Noriko Miyake, Shiro Ikegawa, Long Guo SLC4A2 Deficiency Causes a New Type of Osteopetrosis J Bone Miner Res 2022 37(2):226-235 PubMed ID: 34668226 DOI: 10.1002/jbmr.4462

20578 Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Yatani H, Nishimura I, Egusa H. Cyclic Pressure-Induced Cytokines from Gingival Fibroblasts Stimulate Osteoclast Activity: Clinical Implications for Alveolar Bone Loss in Denture Wearers. J Prosthodont Res 2022 PubMed ID: 35185110 DOI: 10.2186/jpr.JPR_D_21_00238

16345 Kumawat M, Madhyastha H, Umapathi A, Singh M, Revaprasadu N, Daima HK. Surface Engineered Peroxidase-Mimicking Gold Nanoparticles to Subside Cell Inflammation Langmuir 2022 38(5):1877-1887 PubMed ID: 35099982 DOI: 10.1021/acs.langmuir.1c03088

16431 Do KM, Shin MK, Kodama T, Win NN, Prema P, Nguyen HM, Hayakawa Y, Morita H. Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation Planta Med 2022 88(11):913-920 PubMed ID: 34474490 DOI: 10.1055/a-1585-5877

20620 Kieu TQ, Tazawa K, Kawashima N, Noda S, Fujii M, Nara K, Hashimoto K, Han P, Okiji T. Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Sci Rep 2022 12(1):5176 PubMed ID: 35338195 DOI: 10.1038/s41598-022-08987-3

20635 Shinomiya K, Mukai A, Ito E, Yoneda K, Ueno M, Sotozono C, Kinoshita S, Hamuro J. Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration. Jpn J Ophthalmol 2022 PubMed ID: 35397057 DOI: 10.1007/s10384-022-00913-4

20655 Temizoz B, Hioki K, Kobari S, Jounai N, Kusakabe T, Lee MSJ, Coban C, Kuroda E, Ishii KJ. Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation. Int Immunol 2022 PubMed ID: 35419609 DOI: 10.1093/intimm/dxac012

20689 Li W, Miyashita A, Sekimizu K. Peanut triacylglycerols activate innate immunity both in insects and mammals. Sci Rep 2022 12(1):7464 PubMed ID: 35523841 DOI: 10.1038/s41598-022-11494-0

16504 Zhou Y, Takano T, Li X, Wang Y, Wang R, Zhu Z, Tanokura M, Miyakawa T, Hachimura S. β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway Commun Biol 2022 5(1):519 PubMed ID: 35641589 DOI: 10.1038/s42003-022-03369-x

16619 Mohamed IMA, Jamsransuren D, Matsuda S, Ogawa H, Takeda Y. Impact of Theaflavins-Enriched Tea Leaf Extract TY-1 against Surrogate Viruses of Human Norovirus: In Vitro Virucidal Study Pathogens 2022 11(5):533 PubMed ID: 35631054 DOI: 10.3390/pathogens11050533

16642 Gulay KCM, Aoshima K, Maekawa N, Suzuki T, Konnai S, Kobayashi A, Kimura T. Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages Sci Rep 2022 12(1):2124 PubMed ID: 35136176 DOI: 10.1038/s41598-022-06203-w

16558 Ito S, Nishiguchi A, Ichimaru H, Nagasaka K, Hirade H, Taguchi T. Prevention of postoperative adhesion with a colloidal gel based on decyl group-modified Alaska pollock gelatin microparticles Acta Biomater 2022 S1742-7061(22)00354-3 PubMed ID: 35697199 DOI: 10.1016/j.actbio.2022.06.014

16540 Elia Marin, Tetsuya Adachi, Francesco Boschetto, Wenliang Zhu, Keiji Adachi, Narisato Kanamura, Toshiro Yamamoto, Giuseppe Pezzotti Raman Spectroscopic Investigation of Osteoclastic Activity under the Influence of Bisphosphonate Applied Sciences 2022 12:3757 DOI: 10.3390/app12083757

16385 Shan Q, Takabatake K, Kawai H, Oo MW, Inada Y, Sukegawa S, Fushimi S, Nakano K, Nagatsuka H. Significance of cancer stroma for bone destruction in oral squamous cell carcinoma using different cancer stroma subtypes Oncol Rep 2022 47(4):81 PubMed ID: 35211756 DOI: 10.3892/or.2022.8292

20820 Kurata A, Kiyohara S, Imai T, Yamasaki-Yashiki S, Zaima N, Moriyama T, Kishimoto N, Uegaki K. Characterization of extracellular vesicles from Lactiplantibacillus plantarum. Sci Rep 2022 12(1):13330 PubMed ID: 35941134 DOI: 10.1038/s41598-022-17629-7

20823 Shi Y, Yasui M, Hara-Chikuma M. AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression. Biochem Biophys Rep 2022 31:101317 PubMed ID: 35967760 DOI: 10.1016/j.bbrep.2022.101317

17097 Kartikasari N, Yamada M, Watanabe J, Tiskratok W, He X, Kamano Y, Egusa H. Titanium surface with nanospikes tunes macrophage polarization to produce inhibitory factors for osteoclastogenesis through nanotopographic cues Acta Biomater 2022 137:316-330 PubMed ID: 34673230 DOI: 10.1016/j.actbio.2021.10.019

20837 Ueno S, Sudo T, Saya H, Sugihara E. Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages. Commun Biol 2022 5(1):904 PubMed ID: 36056141 DOI: 10.1038/s42003-022-03837-4

20863 Tanaka KI, Nakaguchi S, Shiota S, Nakada Y, Oyama K, Sakakibara O, Shimoda M, Sugimoto A, Ichitani M, Takihara T, Kinugasa H, Kawahara M. Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants. Biomolecules 2022 12(9) PubMed ID: 36139034 DOI: 10.3390/biom12091196

20886 Shan Q, Takabatake K, Omori H, Kawai H, Oo MW, Sukegawa S, Fujii M, Inada Y, Sano S, Nakano K, Nagatsuka H. Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line-derived xenograft model. Oncol Lett 2022 24(5):382 PubMed ID: 36238359 DOI: 10.3892/ol.2022.13502

20903 Kumawat M, Madhyastha H, Singh M, Revaprasadu N, Srinivas SP, Daima HK. Double functionalized haemocompatible silver nanoparticles control cell inflammatory homeostasis. PLoS One 2022 17(10):e0276296 PubMed ID: 36269783 DOI: 10.1371/journal.pone.0276296

17314 Ota N, Tanaka N, Sato A, Shen Y, Yalikun Y, Tanaka Y. Microenvironmental Analysis and Control for Local Cells under Confluent Conditions via a Capillary-Based Microfluidic Device Anal Chem 2022 Nov 16 PubMed ID: 36383697 DOI: 10.1021/acs.analchem.2c02815

17328 Azumi J, Shimada Y, Takeda T, Aso H, Nakamura T. The Organogermanium Compound 3-(Trihydroxygermyl) Propanoic Acid (THGP) Suppresses Inflammasome Activation Via Complexation with ATP J Biol Chem 2022 298(12):102676 PubMed ID: 36362152 DOI: 10.3390/ijms232113364

20959 Akita Y, Higashiyama M, Kurihara C, Ito S, Nishii S, Mizoguchi A, Inaba K, Tanemoto R, Sugihara N, Hanawa Y, Wada A, Horiuchi K, Okada Y, Narimatsu K, Komoto S, Tomita K, Takei F, Satoh Y, Saruta M, Hokari R. Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids. Dig Dis Sci 2022 PubMed ID: 36478314 DOI: 10.1007/s10620-022-07781-5

20962 Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, Sasaki T, Kudoh K, Ito K, Sango K, Nagai R, Yamamoto Y, Daimon M, Yamamoto H, Yagihashi S. RAGE activation in macrophages and development of experimental diabetic polyneuropathy. JCI Insight 2022 7(23) PubMed ID: 36477360 DOI: 10.1172/jci.insight.160555

20979 Motani K, Saito-Tarashima N, Nishino K, Yamauchi S, Minakawa N, Kosako H. The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER. Cell Rep 2022 41(12):111868 PubMed ID: 36543137 DOI: 10.1016/j.celrep.2022.111868

20989 Zhao D, Tu ATT, Shobo M, Le NBT, Yoshikawa C, Sugai K, Hakamata Y, Yamazaki T. Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-L-Lysine Induce Antibody Production as Vaccine Adjuvants. Biomolecules 2022 12(12) PubMed ID: 36551297 DOI: 10.3390/biom12121868

21025 Kojima S, Hakamata M, Asanuma T, Suzuki R, Tsuruda JI, Nonoyama T, Lin Y, Fukatsu H, Koide N, Umezawa K. Cellular Anti-Inflammatory and Antioxidant Activities of Bamboo Sasa albomarginata Leaf Extract and Its Constituent Coumaric Acid Methyl Ester. ScientificWorldJournal 2022 8454865 PubMed ID: 36330350 DOI: 10.1155/2022/8454865

17436 Watanabe M, Yahagi T, Shirayama T, Miyake K, Kotani H, Ogawa T, Matsuzaki K. Effects of a Whole Plant Extract of Scutellaria rubropunctata var. rubropunctata on Bone Metabolism with Estrogen Receptor Activation Plants (Basel) 2022 11(16):2075 PubMed ID: 36015379 DOI: 10.3390/plants11162075

11900 Fujihara Y, Abe T, Asawa Y, Nishizawa S, Saijo H, Hikita A, Hoshi K. Influence of Damage-Associated Molecular Patterns from Chondrocytes in Tissue-Engineered Cartilage. Tissue Eng Part A 2021 27(1-2):1-9 PubMed ID: 31724485 DOI: 10.1089/ten.TEA.2019.0185

13272 Tanaka KI, Kubota M, Shimoda M, Hayase T, Miyaguchi M, Kobayashi N, Ikeda M, Ishima Y, Kawahara M. Thioredoxin-albumin fusion protein prevents urban aerosol-induced lung injury via suppressing oxidative stress-related neutrophil extracellular trap formation. Environ Pollut 2021 PubMed ID: 33065363 DOI: 10.1016/j.envpol.2020.115787

13373 Kuriyama T, Fukuma Y, Imashiro C, Kabayama K, Kurashina Y, Takemura K. Detachment of RAW264.7 macrophages from a culture dish using ultrasound excited by a Langevin transducer. J Biosci Bioeng 2021 131(3):320-325 PubMed ID: 33250410 DOI: 10.1016/j.jbiosc.2020.11.003

13464 Sugiyama T, Hobro AJ, Pavillon N, Umakoshi T, Verma P, Smith N. Label-free Raman mapping of saturated and unsaturated fatty acid uptake, storage, and return toward baseline levels in macrophages Analyst 2021 146(4):1268-1280 PubMed ID: 33346264 DOI: 10.1039/d0an02077j

20004 Wada Y, Iyoda M, Matsumoto K, Suzuki T, Tachibana S, Kanazawa N, Honda H. Reno-protective effect of IL-34 inhibition on cisplatin-induced nephrotoxicity in mice. PLoS One 2021 16(1):e0245340 PubMed ID: 33428678 DOI: 10.1371/journal.pone.0245340

20009 Li SW, Takahara T, Que W, Fujino M, Guo WZ, Hirano SI, Ye LP, Li XK. Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling. Am J Physiol Gastrointest Liver Physiol 2021 PubMed ID: 33439102 DOI: 10.1152/ajpgi.00158.2020

20023 Madhyastha R, Madhyastha H, Nurrahmah QI, Purbasari B, Maruyama M, Nakajima Y. MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles. Inflammation 2021 PubMed ID: 33501624 DOI: 10.1007/s10753-021-01415-0

20065 Ma'mag LK, Zintchem AAA, Théodora KK, de Théodore AA, Lauve TY, Frédérich M, Bikobo DSN, Pegnyemb DE. Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae). Fitoterapia 2021 104869 PubMed ID: 33657429 DOI: 10.1016/j.fitote.2021.104869

20088 Nurrahmah QI, Madhyastha R, Madhyastha H, Purbasari B, Maruyama M, Nakajima Y. Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B/miR-21 signaling. Immunopharmacol Immunotoxicol 2021 1-10 PubMed ID: 33757404 DOI: 10.1080/08923973.2021.1902348

20176 Pengjam Y, Prajantasen T, Tonwong N, Panichayupakaranant P. Downregulation of miR-21 gene expression by CRE-Ter to modulate osteoclastogenesis: De Novo mechanism. Biochem Biophys Rep 2021 26:101002 PubMed ID: 33997317 DOI: 10.1016/j.bbrep.2021.101002

20196 Sano K, Miki M, Tanaka T, Munemura M, Munekane M, Yamasaki T, Mukai T. Electrostatically self-assembled gold nanorods with chondroitin sulfate for targeted photothermal therapy for melanoma. Photodiagnosis Photodyn Ther 2021 102402 PubMed ID: 34144259 DOI: 10.1016/j.pdpdt.2021.102402

20197 Ju N, Hayashi H, Shimamura M, Yoshida S, Nakamaru R, Nakagami H, Morishita R, Rakugi H. Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice. Immunohorizons 2021 5(6):438-447 PubMed ID: 34131020 DOI: 10.4049/immunohorizons.2000112

20199 Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun 2021 12(1):3655 PubMed ID: 34135341 DOI: 10.1038/s41467-021-23969-1

20243 Hattori H, Takaoka K, Ueta M, Oshitani M, Tamaoka J, Noguchi K, Kishimoto H. Senescent RAW264.7 cells exhibit increased production of nitric oxide and release inducible nitric oxide synthase in exosomes. Mol Med Rep 2021 24(3) PubMed ID: 34318909 DOI: 10.3892/mmr.2021.12320

20258 Yokota S, Matsumae G, Shimizu T, Hasegawa T, Ebata T, Takahashi D, Heguo C, Tian Y, Alhasan H, Takahata M, Kadoya K, Terkawi MA, Iwasaki N. Cardiotrophin like cytokine factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway. Bone 2021 116140 PubMed ID: 34364014 DOI: 10.1016/j.bone.2021.116140

20264 Kawai K, Nishigaki A, Moriya S, Egami Y, Araki N. Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages. Front Immunol 2021 12:649600 PubMed ID: 34135890 DOI: 10.3389/fimmu.2021.649600

20271 Takahashi F, Endo K, Matsui R, Yamamoto K, Tanaka S. Brassica rapa L. activates macrophages via Toll-like receptors. Biosci Biotechnol Biochem 2021 85(3):656-665 PubMed ID: 33589925 DOI: 10.1093/bbb/zbaa075

15168 Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells Nat Immunol 2021 22(8):947-957 PubMed ID: 34239121 DOI: 10.1038/s41590-021-00967-5

20285 Pavillon N, Smith NI. Deriving accurate molecular indicators of protein synthesis through Raman-based sparse classification. Analyst 2021 146(11):3633-3641 PubMed ID: 33949431 DOI: 10.1039/d1an00412c

20313 Yamaguchi M, Takagi K, Sato M, Sato A, Miki Y, Onodera Y, Miyashita M, Sasano H, Suzuki T. Androgens enhance the ability of intratumoral macrophages to promote breast cancer progression. Oncol Rep 2021 46(3) PubMed ID: 34278480 DOI: 10.3892/or.2021.8139

20315 Cheng TY, Lin YJ, Saburi W, Vieths S, Scheurer S, Schülke S, Toda M. β-(1→4)-Mannobiose Acts as an Immunostimulatory Molecule in Murine Dendritic Cells by Binding the TLR4/MD-2 Complex. Cells 2021 10(7) PubMed ID: 34359943 DOI: 10.3390/cells10071774

15262 Tanikawa T, Kitamura M, Hayashi Y, Tomida N, Uwaya A, Isami F, Inoue Y. Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells Medicines (Basel) 2021 8(8):43 PubMed ID: 34436222 DOI: 10.3390/medicines8080043

15263 Hiromu Ito Peroxynitrite Production Induced by LPS and X-ray Treatment Enhances Cellular Incorporation of Porphyrin in Mouse RAW264 Macrophages Applied Sciences 2021 11:3503 DOI: 10.3390/app11083503

15264 Yamasaki M, Yamasaki Y, Furusho R, Kimura H, Kamei I, Sonoda H, Ikeda M, Oshima T, Ogawa K, Nishiyama K. Onion ( Allium cepa L.)-Derived Nanoparticles Inhibited LPS-Induced Nitrate Production, However, Their Intracellular Incorporation by Endocytosis Was Not Involved in This Effect on RAW264 Cells Molecules 2021 26(9):2763 PubMed ID: 34067155 DOI: 10.3390/molecules26092763

15265 Nipitpon Srimai, Wasawat Kiatarkom, Hidetake Miyata Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells International Journal of Chemistry 2021 13:12-20 DOI: 10.5539/ijc.v13n1p12

15266 Kitazawa R, Haraguchi R, Kohara Y, Kitazawa S. RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter Biochem Biophys Res Commun 2021 572:86-91 PubMed ID: 34358968 DOI: 10.1016/j.bbrc.2021.07.100

15267 Noguchi T, Hidaka K, Kobayashi S, Matsumoto K, Yoshioka M, Hu X, Maloney DJ, Yang SM, Kato S. A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression Drug Dev Res 2021 21 Jun 1 PubMed ID: 34075610 DOI: 10.1002/ddr.21838

15268 Tsuchiya K, Hosojima S, Hara H, Kushiyama H, Mahib MR, Kinoshita T, Suda T. Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes Cell Rep 2021 34(12):108887 PubMed ID: 33761363 DOI: 10.1016/j.celrep.2021.108887

15269 Takahashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S. Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice Neurobiol Dis 2021 155:105392 PubMed ID: 34000416 DOI: 10.1016/j.nbd.2021.105392

15270 Shinjyo N, Nakayama H, Li L, Ishimaru K, Hikosaka K, Suzuki N, Yoshida H, Norose K. Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro J Ethnopharmacol 2021 267:113525 PubMed ID: 33129946 DOI: 10.1016/j.jep.2020.113525

15271 Kimura H, Tokuyama-Nakai S, Hirabayashi Y, Ishihara T, Jisaka M, Yokota K. Anti-inflammatory and bioavailability studies on dietary 3,5,4'-trihydroxy-6,7-methylenedioxyflavone-O-glycosides and their aglycone from indigo leaves in a murine model of inflammatory bowel disease J Pharm Biomed Anal 2021 193:113716 PubMed ID: 33152603 DOI: 10.1016/j.jpba.2020.113716

15272 Xi Yang, Satoru Komatsu, Sheethal Reghu, Eijiro Miyako Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics Nano Today 2021 37:101100 DOI: 10.1016/j.nantod.2021.101100

15276 Yoshida H, Tsuhako R, Sugita C, Kurokawa M. Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice Biol Pharm Bull 2021 44(3):422-430 PubMed ID: 33642550 DOI: 10.1248/bpb.b20-00849

15280 Yukino Tsunekage, Masatoshi Takeiri, Yuri Yoshioka, Shinichi Matsumura, Yoshihide Kimura, Kohsuke Kataoka Nasturtium officinale Extract Suppresses Osteoclastogenesis in RAW 264 Cells by Inhibiting IκB-Kinase β Natural Product Communications 2021 16:1934578X2110206 DOI: 10.1177/1934578x211020643

15285 Fuchi Y, Murase H, Kai R, Kurata K, Karasawa S, Sasaki S. Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells Bioconjug Chem 2021 32(2):385-393 PubMed ID: 33529519 DOI: 10.1021/acs.bioconjchem.1c00012

20352 Takenaga K, Koshikawa N, Nagase H. Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles. BMC Mol Cell Biol 2021 22(1):52 PubMed ID: 34615464 DOI: 10.1186/s12860-021-00391-5

15684 Kwaffo YA, Sarpong-Duah M, Owusu-Boateng K, Gbewonyo WS, Adjimani JP, Mosi L. Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages Exp Biol Med (Maywood) 2021 246(17):1884-1894 PubMed ID: 34038223 DOI: 10.1177/15353702211015628

20457 Hiyoshi M, Takahashi N, Eltalkhawy YM, Noyori O, Lotfi S, Panaampon J, Okada S, Tanaka Y, Ueno T, Fujisawa JI, Sato Y, Suzuki T, Hasegawa H, Tokunaga M, Satou Y, Yasunaga JI, Matsuoka M, Utsunomiya A, Suzu S. M-Sec induced by HTLV-1 mediates an efficient viral transmission. PLoS Pathog 2021 17(11):e1010126 PubMed ID: 34843591 DOI: 10.1371/journal.ppat.1010126

15891 Rimpei Kamegawa, Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, Beob Soo Kim, Kanjiro Miyata Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery ACS Applied Bio Materials 2021 4:7790-7799 PubMed ID: 35006762 DOI: 10.1021/acsabm.1c00704

20495 Safitri FA, Tu ATT, Hoshi K, Shobo M, Zhao D, Witarto AB, Sumarsono SH, Giri-Rachman EA, Tsukakoshi K, Ikebukuro K, Yamazaki T. Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold. Biomolecules 2021 11(11) PubMed ID: 34827615 DOI: 10.3390/biom11111617

16221 Yiting Li, Litong Ban, Shili Meng, Liang Huang, Ning Sun, Hongpeng Yang, Yu Wang, Linbo Wang Bioactivities of crude polysaccharide extracted from fermented soybean curd residue by Cordyceps militaris Biotechnology & Biotechnological Equipment 2021 35:342-353 DOI: 10.1080/13102818.2021.1875874

16374 Xiao L, Shiwaku Y, Hamai R, Tsuchiya K, Sasaki K, Suzuki O. Macrophage Polarization Related to Crystal Phases of Calcium Phosphate Biomaterials Int J Mol Sci 2021 22(20):11252 PubMed ID: 34681912 DOI: 10.3390/ijms222011252

16531 Nakashima Y, Gotoh K, Mizuguchi S, Setoyama D, Takata Y, Kanno T, Kang D. Attenuating Effect of Chlorella Extract on NLRP3 Inflammasome Activation by Mitochondrial Reactive Oxygen Species Front Nutr 2021 8:763492 PubMed ID: 34692754 DOI: 10.3389/fnut.2021.763492

17766 Nishiguchi A, Taguchi T. Designing an anti-inflammatory and tissue-adhesive colloidal dressing for wound treatment Colloids Surf B Biointerfaces 2020 188:110737 PubMed ID: 32004904 DOI: 10.1016/j.colsurfb.2019.110737

17767 Yamano A, Natsume N, Yamada M, Sumimoto S, Iwasaki A, Suenaga K, Teruya T. Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium J Nat Prod 2020 83(5):1585-1591 PubMed ID: 32267694 DOI: 10.1021/acs.jnatprod.0c00042

11608 Tsuhako R, Yoshida H, Sugita C, Kurokawa M. Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice. J Nat Med 2020 74(1):229-237. PubMed ID: 31218550 DOI: 10.1007/s11418-019-01332-5

11704 Miori Tanaka, Ayako Sugama, Kanako Sumi, Kozue Shimizu, Yoshimi Kishimoto, Kazuo Kondo, Kaoruko Iida Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo Nutrition Research 2020 73:58-66 PubMed ID: 31841748 DOI: 10.1016/j.nutres.2019.09.007

11757 Manabe Y, Takii Y, Sugawara T. Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses. J Nat Med 2020 74(1):127-134 PubMed ID: 31432315 DOI: 10.1007/s11418-019-01354-z

11863 Yamada K, Takizawa S, Ohgaku Y, Asami T, Furuya K, Yamamoto K, Takahashi F, Hamajima C, Inaba C, Endo K, Matsui R, Kitamura H, Tanaka S. MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. Gene 2020 PubMed ID: 31654705 DOI: 10.1016/j.gene.2019.144191

6906 Shinjyo N, Nakayama H, Ishimaru K, Hikosaka K, Mi-Ichi F, Norose K, Yoshida H. Hypericum erectum alcoholic extract inhibits Toxoplasma growth and Entamoeba encystation: an exploratory study on the anti-protozoan potential. J Nat Med 2020 74(1):294-305 PubMed ID: 31728823 DOI: 10.1007/s11418-019-01369-6

12001 Yoshimoto Y, Jo JI, Tabata Y. Preparation of antibody-immobilized gelatin nanospheres incorporating a molecular beacon to visualize the biological function of macrophages. Regen Ther 2020 PubMed ID: 31970268 DOI: 10.1016/j.reth.2019.12.009

12006 Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S. Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31964526 DOI: 10.1016/j.bbrc.2020.01.065

12009 Bandow K, Hasegawa H, Tomomura M, Tomomura A. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31973822 DOI: 10.1016/j.bbrc.2020.01.045

12016 Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. Sci Rep 2020 PubMed ID: 31969650 DOI: 10.1038/s41598-020-57935-6

12026 Tanaka M, Miyake H, Oka S, Maeda S, Iwasaki K, Mukai T. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochim Biophys Acta Biomembr 2020 PubMed ID: 32004520 DOI: 10.1016/j.bbamem.2020.183209

12048 Funakoshi-Tago M, Nonaka Y, Tago K, Takeda M, Ishihara Y, Sakai A, Matsutaka M, Kobata K, Tamura H. Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2. Sci Rep 2020 PubMed ID: 32054966 DOI: 10.1038/s41598-020-59380-x

12058 Phan TKT, Shahbazzadeh F, Kihara T. Alpha-mangostin reduces mechanical stiffness of various cells. Hum. Cell 2020 PubMed ID: 32078151 DOI: 10.1007/s13577-020-00330-0

12092 Kamiya Y, Kikuchi T, Goto H, Okabe I, Takayanagi Y, Suzuki Y, Sawada N, Okabe T, Suzuki Y, Kondo S, Hayashi JI, Mitani A. IL-35 and RANKL Synergistically Induce Osteoclastogenesis in RAW264 Mouse Monocytic Cells. Int J Mol Sci 2020 PubMed ID: 32197293 DOI: 10.3390/ijms21062069

12110 Uchikawa M, Kato M, Nagata A, Sanada S, Yoshikawa Y, Tsunematsu Y, Sato M, Suzuki T, Hashidume T, Watanabe K, Yoshikawa Y, Miyoshi N. Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-A^y mice. Sci Rep 2020 PubMed ID: 32231228 DOI: 10.1038/s41598-020-62541-7

12126 Amlabu WE, Antwi CA, Awandare G, Gwira TM. Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani. PLoS Negl Trop Dis 2020 PubMed ID: 32275665 DOI: 10.1371/journal.pntd.0008188

12130 Sanada S, Suzuki T, Nagata A, Hashidume T, Yoshikawa Y, Miyoshi N. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep 2020 PubMed ID: 32296105 DOI: 10.1038/s41598-020-63627-y

12171 Kazunori Sasaki, Yuri Inami, Kenichi Tominaga, Hideo Kigoshi, Takashi Arimura , and Hiroko Isoda Synthesis of 2-(2-Hydroxyethoxy)-3-hydroxysqualene and Characterization of Its Anti-Inflammatory Effects BioMed Research International 2020 PubMed ID: 32382581 DOI: 10.1155/2020/9584567

10948 Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages Front Immunol 2020 11:709 PubMed ID: 32373130 DOI: 10.3389/fimmu.2020.00709

12488 Takeda Y, Murata T, Jamsransuren D, Suganuma K, Kazami Y, Batkhuu J, Badral D, Ogawa H. Saxifraga spinulosa-Derived Components Rapidly Inactivate Multiple Viruses Including SARS-CoV-2 Viruses 2020 12(7):699 PubMed ID: 32605306 DOI: 10.3390/v12070699

13012 Kumagai M, Nishikawa K, Mishima T, Yoshida I, Ide M, Watanabe A, Fujita K, Morimoto Y. Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells. Biol Pharm Bull 2020 PubMed ID: 32378565 DOI: 10.1248/bpb.b20-00063

13036 Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K. Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. Nutrients 2020 PubMed ID: 32443660 DOI: 10.3390/nu12051479

13065 Crentsil JA, Yamthe LRT, Anibea BZ, Broni E, Kwofie SK, Tetteh JKA, Osei-Safo D. Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus. Front Pharmacol 2020 PubMed ID: 32523532 DOI: 10.3389/fphar.2020.00753

13097 Kim Y, Wu L, Park HC, Yang HC. Reduction of fibrous encapsulation by polyethylene glycol-grafted liposomes containing phosphatidylserine. Biomed Mater 2020 PubMed ID: 32615550 DOI: 10.1088/1748-605X/aba238

13137 Kawata R, Oda S, Koya Y, Kajiyama H, Yokoi T. Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production. Toxicology 2020 PubMed ID: 32739513 DOI: 10.1016/j.tox.2020.152544

13139 Kawai K, Egami Y, Nishigaki A, Araki N. Rab35 Targeting to the Plasma Membrane Is Dependent on the C-terminal Polybasic Cluster. Acta Histochem Cytochem 2020 PubMed ID: 32873993 DOI: 10.1267/ahc.20-00006

13146 Ertunc N, Sato C, Kitajima K. Sialic acid sulfation is induced by the antibiotic treatment in mammalian cells. Biosci Biotechnol Biochem 2020 PubMed ID: 32752946 DOI: 10.1080/09168451.2020.1792763

13150 Totani H, Shinjo K, Suzuki M, Katsushima K, Mase S, Masaki A, Ito A, Ri M, Kusumoto S, Komatsu H, Ishida T, Inagaki H, Iida S, Kondo Y. Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma. Oncogene 2020 PubMed ID: 32747750 DOI: 10.1038/s41388-020-01393-x

13168 Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T. Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue. Mol Biol Rep 2020 PubMed ID: 32808115 DOI: 10.1007/s11033-020-05727-6

13180 Wada S, Kanzaki H, Katsumata Y, Yamaguchi Y, Narimiya T, Attucks OC, Nakamura Y, Tomonari H. Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation. Front Cell Dev Biol 2020 PubMed ID: 32850850 DOI: 10.3389/fcell.2020.00740

13258 Takeuchi T, Horimoto Y, Oyama M, Nakatani S, Kobata K, Tamura M, Arata Y, Hatanaka T. Osteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment. Biol Pharm Bull 2020 PubMed ID: 32999159 DOI: 10.1248/bpb.b20-00221

13294 Nishigaki C, Nakayama M, Miyata H. Cell physiological responses of RAW264 macrophage cells to a 50-Hz magnetic field. Int J Radiat Biol 2020 PubMed ID: 33052723 DOI: 10.1080/09553002.2020.1837983

13298 Yang X, Sasano T, Ebana Y, Takeuchi JK, Ihara K, Yamazoe M, Furukawa T. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation. Circ J 2020 PubMed ID: 33087629 DOI: 10.1253/circj.CJ-20-0101

13324 Yahiro K, Ogura K, Goto Y, Iyoda S, Kobayashi T, Takeuchi H, Ohnishi M, Moss J. Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival. Sci Rep 2020 PubMed ID: 33144618 DOI: 10.1038/s41598-020-76027-z

13341 Matur M, Madhyastha H, Shruthi TS, Madhyastha R, Srinivas SP, Navya PN, Daima HK. Engineering bioactive surfaces on nanoparticles and their biological interactions. Sci Rep 2020 PubMed ID: 33184324 DOI: 10.1038/s41598-020-75465-z

13434 Frederick Ayertey, Ebenezer Ofori-Attah, Stephen Antwi, Michael Amoa-Bosompem, Georgina Djameh, Nathaniel Lartey Lartey, Mistuko Ohashi, Kwadwo Asamoah Kusi, Alfred Ampomah Appiah, Regina Appiah-Opong, Laud Kenneth Okine Anti-inflammatory activity and mechanism of action of ethanolic leaf extract of Morinda lucida Benth Journal of Traditional and Complementary Medicine 2020 PubMed ID: 34012871 DOI: 10.1016/j.jtcme.2020.07.001

13492 Masanori HASHIMOTO, Haruaki KITAGAWA, Yusuke TAKAHASHI, Mikako HAYASHI, Satoshi IMAZATO Cytotoxicity of S-PRG Fillers: Direct Exposure of Fillers and Eluates from the Fillers to RAW264 Cells Nano Biomedicine 2020 12:3-10 DOI: 10.11344/nano.12.3

13545 Quan H, Kim Y, Wu L, Park HC, Yang HC. Modulation of Macrophage Polarization by Phospholipids on the Surface of Titanium Molecules 2020 25(11):2700 PubMed ID: 32532146 DOI: 10.3390/molecules25112700

13614 Kuramoto M, Kawashima N, Tazawa K, Nara K, Fujii M, Noda S, Hashimoto K, Nozaki K, Okiji T. Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages Int Endod J 2020 53(12):1653-1665 PubMed ID: 32767860 DOI: 10.1111/iej.13386

13633 Lu DZ, Dong W, Feng XJ, Chen H, Liu JJ, Wang H, Zang LY, Qi MC. CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway Mol Cell Endocrinol 2020 508:110791 PubMed ID: 32173349 DOI: 10.1016/j.mce.2020.110791

13639 Nishiguchi A, Taguchi T. Development of an immunosuppressive camouflage-coating platform with nanocellulose and cell membrane vesicles J Biomater Sci Polym Ed 2020 31(15):1912-1924 PubMed ID: 32538290 DOI: 10.1080/09205063.2020.1783060

13643 Nishiguchi A, Taguchi T. Sustained-immunostimulatory nanocellulose scaffold to enhance vaccine efficacy J Biomed Mater Res A 2020 108(5):1159-1170 PubMed ID: 31990447 DOI: 10.1002/jbm.a.36890

13906 Ide M, Yoshida I, Kumagai M, Mishima T, Takahashi Y, Fujita K, Igarashi T, Matsuura E. Tithonia diversifolia-derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP-1 cells J Food Biochem 2020 44(7):e13268 PubMed ID: 32412116 DOI: 10.1111/jfbc.13268

15459 Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, Kataoka Y, Yamauchi A. Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression J Pharmacol Sci 2020 142(1):9-15 PubMed ID: 31771811 DOI: 10.1016/j.jphs.2019.11.002

16615 Aki T, Funakoshi T, Noritake K, Unuma K, Uemura K. Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells Sci Rep 2020 10(1):10581 PubMed ID: 32601294 DOI: 10.1038/s41598-020-67396-6

16816 Chie Kojima, Risa Katayama, Thi Lien Nguyen, Yuto Oki, Ayako Tsujimoto, Shin-ichi Yusa, Kohei Shiraishi, Akikazu Matsumoto Different antifouling effects of random and block copolymers comprising 2-methacryloyloxyethyl phosphorylcholine and dodecyl methacrylate European Polymer Journal 2020 136:109932 DOI: 10.1016/j.eurpolymj.2020.109932

16824 Natsuki Hayakawa, Takuya Yamada, Yukiya Kitayama, Toshifumi Takeuchi Cellular Interaction Regulation by Protein Corona Control of Molecularly Imprinted Polymer Nanogels Using Intrinsic Proteins ACS Applied Polymer Materials 2020 2:1465-1473 DOI: 10.1021/acsapm.9b01149

11167 Chaweewannakorn W, Ariyoshi W, Okinaga T, Fujita Y, Maki K, Nishihara T. Ameloblastin attenuates RANKL-mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T-cell cytoplasmic 1 (NFATc1). J. Cell. Physiol. 2019 234(2):1745-175 PubMed ID: 30105896 DOI: 10.1002/jcp.27045

11173 Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M. The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. J Nat Med 2019 73(1):59-66 PubMed ID: 30116953 DOI: 10.1007/s11418-018-1237-3

11279 Sun S, Li K, Xiao L, Lei Z, Zhang Z. Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7. Biomed. Pharmacother. 2019 PubMed ID: 30396084 DOI: 10.1016/j.biopha.2018.10.039

11335 Abe T, Sumi K, Kunimatsu R, Oki N, Tsuka Y, Nakajima K, Ando K, Tanimoto K. The effect of mesenchymal stem cells on osteoclast precursor cell differentiation. J Oral Sci 2019 PubMed ID: 30541990 DOI: 10.2334/josnusd.17-0315

11361 Islam Z, Inui T, Ishibashi O. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30595385 DOI: 10.1016/j.bbrc.2018.12.140

11380 Nemoto R, Fujieda K, Hiruta Y, Hishida M, Ayano E, Maitani Y, Nagase K, Kanazawa H. Liposomes with temperature-responsive reversible surface properties. Colloids Surf B Biointerfaces 2019 PubMed ID: 30641302 DOI: 10.1016/j.colsurfb.2019.01.007

11396 Yoshinaga N, Uchida S, Naito M, Osada K, Cabral H, Kataoka K. Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials 2019 PubMed ID: 30669016 DOI: 10.1016/j.biomaterials.2019.01.023

11383 Manabe Y, Hirata T, Sugawara T. Inhibitory Effect of Carotenoids on Ligand-induced Lipid Raft Translocation of Immunoreceptors. J Oleo Sci 2019 PubMed ID: 30651415 DOI: 10.5650/jos.ess18204

11389 Wang W, Nakashima KI, Hirai T, Inoue M. Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers. J Nat Med 2019 PubMed ID: 30656541 DOI: 10.1007/s11418-018-01277-1

11457 Takahashi S, Yoshida M, Watanabe MM, Isoda H. Anti-Inflammatory Effects of Aurantiochytrium limacinum 4W-1b Ethanol Extract on Murine Macrophage RAW264 Cells. Biomed Res Int 2019 PubMed ID: 30809537 DOI: 10.1155/2019/3104057

11437 Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee J, Iimura T, Imai Y. Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin. Bone 2019 PubMed ID: 30771488 DOI: 10.1016/j.bone.2019.02.011

11454 Antwi CA, Amisigo CM, Adjimani JP, Gwira TM. In vitro activity and mode of action of phenolic compounds on Leishmania donovani. PLoS Negl Trop Dis 2019 PubMed ID: 30802252 DOI: 10.1371/journal.pntd.0007206

11477 Zhang T, Ono K, Tsutsuki H, Ihara H, Islam W, Akaike T, Sawa T. Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock. Cell Chem Biol 2019 PubMed ID: 30853417 DOI: 10.1016/j.chembiol.2019.02.003

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11498 Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M. Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques. J Control Release 2019 PubMed ID: 30936020 DOI: 10.1016/j.jconrel.2019.03.025

11508 Saito H, Tanaka T, Sugahara M, Tanaka S, Fukui K, Wakashima T, Nangaku M. Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet. Lab. Invest. 2019 PubMed ID: 30952940 DOI: 10.1038/s41374-019-0239-4

11539 Suzuka H, Mimura A, Inaoka Y, Murase K. Magnetic Nanoparticles in Macrophages and Cancer Cells Exhibit Different Signal Behavior on Magnetic Particle Imaging. J Nanosci Nanotechnol 2019 PubMed ID: 31039837 DOI: 10.1166/jnn.2019.16619

11604 Miyazaki Y, Iwaihara Y, Bak J, Nakano H, Takeuchi S, Takeuchi H, Matsui T, Tachikawa D. The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 31221482 DOI: 10.1016/j.bbrc.2019.06.010

11617 Takeuchi T, Koinuma S, Yokosawa H, Arata Y. An Approach for the Identification of Proteins Modified with ISG15. Methods Mol. Biol. 2019 PubMed ID: 31256383 DOI: 10.1007/978-1-4939-9055-9_15

11736 Wang X, Batubara I, Yamauchi K, Mitsunaga T. Identification and structure-activity relationship (SAR) of chemical constituents from Daemonorops draco (Willd.) Blume and selected commercial flavonoids on anti-osteoclastogenesis activity. Fitoterapia 2019 PubMed ID: 31376421 DOI: 10.1016/j.fitote.2019.104280

11772 Okuda-Hanafusa C, Uchio R, Fuwa A, Kawasaki K, Muroyama K, Yamamoto Y, Murosaki S. Turmeronol A and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling. Food Funct 2019 PubMed ID: 31454011 DOI: 10.1039/c9fo00336c

11780 Tan H, Zhao C, Zhu Q, Katakura Y, Tanaka H, Ohnuki K, Shimizu K. Ursolic Acid Isolated from the Leaves of Loquat ( Eriobotrya japonica) Inhibited Osteoclast Differentiation through Targeting Exportin 5. J. Agric. Food Chem. 2019 PubMed ID: 30827108 DOI: 10.1021/acs.jafc.8b06954

11793 Mizuno Y, Taguchi T. Growth factor-free, angiogenic hydrogel based on hydrophobically modified Alaska pollock gelatin. J Tissue Eng Regen Med 2019 PubMed ID: 31503405 DOI: 10.1002/term.2957

11801 Ueta M, Takaoka K, Yamamura M, Maeda H, Tamaoka J, Nakano Y, Noguchi K, Kishimoto H. Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro. Mol Med Rep 2019 PubMed ID: 31545488 DOI: 10.3892/mmr.2019.10662

11810 Ara T, Koide M, Kitamura H, Sogawa N. Effects of shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) on prostaglandin E2 production in lipopolysaccharide-treated mouse macrophage RAW264.7 cells. PeerJ 2019 PubMed ID: 31576251 DOI: 10.7717/peerj.7725

11873 Ju N, Shimamura M, Hayashi H, Ikeda Y, Yoshida S, Nakamura A, Morishita R, Rakugi H, Nakagami H. Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis. Sci Rep 2019 PubMed ID: 31659208 DOI: 10.1038/s41598-019-51681-0

6944 Yo S, Hamamura K, Mishima Y, Hamajima K, Mori H, Furukawa K, Kondo H, Tanaka K, Sato T, Miyazawa K, Goto S, Togari A. Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging. Int J Mol Sci 2019 20(11):2825 PubMed ID: 31185614 DOI: 10.3390/ijms20112825

9468 Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma Induction of Lipid Droplets in Non-Macrophage Cells as Well as Macrophages by Liposomes and Exosomes Biochem Biophys Res Commun 2019 510(1):184-190 PubMed ID: 30678809 DOI: 10.1016/j.bbrc.2019.01.078

10512 Sayumi Yamada et al Anti-Inflammatory and Antimicrobial Activities of Aqueous Extracts of Wild Mushrooms from Japan International Journal of Medicinal Mushrooms 2019 21:469-486 DOI: 10.1615/IntJMedMushrooms.2019030637

10763 Ahmed Elkhateeb, Mona El-Shabrawy, Rehab F. Abdel-Rahman, Mona M. Marzouk, Ahmed H. El-Desoky, El-Sayed S. Abdel-Hameed & Sameh R. Hussein LC-MS-based metabolomic profiling of Lepidium coronopus water extract, anti-inflammatory and analgesic activities, and chemosystematic significance Medicinal Chemistry Research 2019 28:505–514 DOI: 10.1007/s00044-019-02309-5

10848 X.YangaZ.Lei, Y.YuaL.Xiao, D.Cheng, Z.Zhang Phytochemical characteristics of callus suspension culture of Helicteres angustifolia L. and its in vitro antioxidant, antidiabetic and immunomodulatory activities South African Journal of Botany 2019 121:178-185 DOI: 10.1016/j.sajb.2018.11.006

11886 Ali MFZ, Ohta T, Ido A, Miura C, Miura T. The Dipterose of Black Soldier Fly (Hermetia illucens) Induces Innate Immune Response through Toll-Like Receptor Pathway in Mouse Macrophage RAW264.7 Cells. Biomolecules 2019 PubMed ID: 31683715 DOI: 10.3390/biom9110677

11908 Pavillon N, Smith NI. Immune cell type, cell activation, and single cell heterogeneity revealed by label-free optical methods. Sci Rep 2019 PubMed ID: 31745140 DOI: 10.1038/s41598-019-53428-3

11914 Shimakura H, Gen-Nagata F, Haritani M, Furusaki K, Kato Y, Yamashita-Kawanishi N, LE DT, Tsuzuki M, Tohya Y, Kyuwa S, Saito H, Horimoto T, Onodera T, Haga T. Inactivation of human norovirus and its surrogate by the disinfectant consisting of calcium hydrogen carbonate mesoscopic crystals. FEMS Microbiol. Lett. 2019 PubMed ID: 31758686 DOI: 10.1093/femsle/fnz235

11948 Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H. Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter. Sci Rep 2019 PubMed ID: 31792273 DOI: 10.1038/s41598-019-54367-9

12316 Kitazawa R, Kinto-Shibahara S, Haraguchi R, Kohara Y, Kitazawa S. Activation of protein kinase C accelerates murine osteoclastogenesis partly via transactivation of RANK gene through functional AP-1 responsive element in RANK gene promoter Biochem Biophys Res Commun 2019 515(2):268-274 PubMed ID: 31146918 DOI: 10.1016/j.bbrc.2019.05.144

12336 Sakakura A, Pauze M, Namiki A, Funakoshi-Tago M, Tamura H, Hanaya K, Higashibayashi S, Sugai T. Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides Biosci Biotechnol Biochem 2019 83(2):185-191 PubMed ID: 30319060 DOI: 10.1080/09168451.2018.1530970

12555 Islam Z, Horikawa A, Inui T, Ishibashi O. Datasets of microarray analysis to identify Gpr137b-dependent interleukin-4-responsive genes in the mouse macrophage cell line RAW264 Data Brief 2019 23:103669 PubMed ID: 31372377 DOI: 10.1016/j.dib.2019.01.017

12556 Saiki P, Kawano Y, Nakajima Y, Van Griensven LJLD, Miyazaki K. Reporters Derived from RAW 264.7 for Anti-Inflammation Screening of Natural Products Int J Mol Sci 2019 20(18):4620 PubMed ID: 31540402 DOI: 10.3390/ijms20184620

12557 Kono Y, Gogatsubo S, Ohba T, Fujita T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field Drug Deliv 2019 26(1):935-943 PubMed ID: 31530198 DOI: 10.1080/10717544.2019.1662515

12559 Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T, Barbie DA, Mukaida N, Takahashi C. Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion Cancer Res 2019 79(15):3903-3915 PubMed ID: 31189648 DOI: 10.1158/0008-5472.CAN-18-3604

12978 Kojima C, Narita Y, Nakajima Y, Morimoto N, Yoshikawa T, Takahashi N, Handa A, Waku T, Tanaka N. Modulation of Cell Adhesion and Differentiation on Collagen Gels by the Addition of the Ovalbumin Secretory Signal Peptide. ACS Biomater Sci Eng 2019 PubMed ID: 33405701 DOI: 10.1021/acsbiomaterials.8b01505

15292 Nagata J, Yokodera H, Maeda G. In Vitro and in Vivo Studies on Anti-Inflammatory Effects of Traditional Okinawan Vegetable Methanol Extracts ACS Omega 2019 4(13):15660-15664 PubMed ID: 31572868 DOI: 10.1021/acsomega.9b02178

10342 Fujihara Y, Hikita A, Takato T, Hoshi K. Roles of macrophage migration inhibitory factor in cartilage tissue engineering. J. Cell. Physiol. 2018 233:1490-1499 PubMed ID: 28574571 DOI: 10.1002/jcp.26036

10432 Tokuyama-Nakai S, Kimura H, Ishihara T, Jisaka M, Yokota K. In Vitro Anti-inflammatory and Antioxidant Activities of 3,5,4'-Trihydroxy-6,7-Methylenedioxyflavone-O-Glycosides and Their Aglycone from Leaves of Polygonum tinctorium Lour. Appl. Biochem. Biotechnol. 2018 184:414-431 PubMed ID: 28721651 DOI: 10.1007/s12010-017-2555-8

10557 Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K. Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells. J. Biochem. 2018 163:143-153 PubMed ID: 29048484 DOI: 10.1093/jb/mvx069

10569 Yamaguchi Y, Kanzaki H, Katsumata Y, Itohiya K, Fukaya S, Miyamoto Y, Narimiya T, Wada S, Nakamura Y. Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation. J. Cell. Mol. Med. 2018 22:1138-1147 PubMed ID: 29063666 DOI: 10.1111/jcmm.13367

10614 Stockler-Pinto MB, Soulage CO, Borges NA, Cardozo LFMF, Dolenga CJ, Nakao LS, Pecoits-Filho R, Fouque D, Mafra D. From bench to the hemodialysis clinic: protein-bound uremic toxins modulate NF-κB/Nrf2 expression. Int Urol Nephrol 2018 50:347-354 PubMed ID: 29151180 DOI: 10.1007/s11255-017-1748-y

10645 Nagahara H, Seno T, Yamamoto A, Obayashi H, Inoue T, Kida T, Nakabayashi A, Kukida Y, Fujioka K, Fujii W, Murakami K, Kohno M, Kawahito Y. Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis. Biochem. Biophys. Res. Commun. 2018 495:1901-1907 PubMed ID: 29225172 DOI: 10.1016/j.bbrc.2017.12.035

10696 Kumagai M, Watanabe A, Yoshida I, Mishima T, Nakamura M, Nishikawa K, Morimoto Y. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol. Pharm. Bull. 2018 41:132-137 PubMed ID: 29311475 DOI: 10.1248/bpb.b17-00607

10708 Kon R, Tsubota Y, Minami M, Kato S, Matsunaga Y, Kimura H, Murakami Y, Fujikawa T, Sakurai R, Tomimoto R, Machida Y, Ikarashi N, Sugiyama K. CPT-11-Induced Delayed Diarrhea Develops via Reduced Aquaporin-3 Expression in the Colon. Int J Mol Sci 2018 19: PubMed ID: 29316651 DOI: 10.3390/ijms19010170

10711 Egami Y, Araki N. Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis. Microscopy (Oxf) 2018 67:68-74 PubMed ID: 29340604 DOI: 10.1093/jmicro/dfx131

10714 Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T. Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway. J Clin Biochem Nutr 2018 62:139-147 PubMed ID: 29610553 DOI: 10.3164/jcbn.17-54

10782 Miyashita T, Minami K, Ito M, Koizumi R, Sagane Y, Watanabe T, Niwa K. Emu Oil Reduces LPS-Induced Production of Nitric Oxide and TNF-α but not Phagocytosis in RAW 264 Macrophages. J Oleo Sci 2018 67:471-477 PubMed ID: 29526880 DOI: 10.5650/jos.ess17228

10790 El-Desoky AH, Abdel-Rahman RF, Ahmed OK, El-Beltagi HS, Hattori M. Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence. Phytomedicine 2018 42:126-134 PubMed ID: 29655678 DOI: 10.1016/j.phymed.2018.03.051

10799 Kawai C, Yamauchi A, Kuribayashi F. Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit. Microbiol. Immunol. 2018 62:269-280 PubMed ID: 29573449 DOI: 10.1111/1348-0421.12584

11027 Miyake T, Miyake T, Sakaguchi M, Nankai H, Nakazawa T, Morishita R. Prevention of Asthma Exacerbation in a Mouse Model by Simultaneous Inhibition of NF-kB and STAT6 Activation Using a Chimeric Decoy Strategy Mol Ther Nucleic Acids 2018 10:159-169 PubMed ID: 29499930 DOI: 10.1016/j.omtn.2017.12.005

11198 Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H. Coupling of bone resorption and formation by RANKL reverse signalling. Nature 2018 561(7722):195-200 PubMed ID: 30185903 DOI: 10.1038/s41586-018-0482-7

4050 Mukai Y, Yamanishi R. Retinol but not retinoic acid can enhance the glutathione level, in a manner similar to β-carotene, in a murine cultured macrophage cell line. Food Sci Nutr 2018 PubMed ID: 30258608 DOI: 10.1002/fsn3.726

11098 Ali MFZ, Yasin IA, Ohta T, Hashizume A, Ido A, Takahashi T, Miura C, Miura T. The silkrose of Bombyx mori effectively prevents vibriosis in penaeid prawns via the activation of innate immunity. Sci Rep 2018 8(1):8836 PubMed ID: 29892000 DOI: 10.1038/s41598-018-27241-3

11116 Tasaka T, Kuwada E, Izuchi Y, Nishigawa R, Yamada H, Unuma H, Tokunaga K, Hayakawa A, Go A, Go K, Uto Y. Concentration-dependent Activation of Inflammatory/Anti-inflammatory Functions of Macrophages by Hydrolyzed Whey Protein. Anticancer Res. 2018 38(7):4299-4304 PubMed ID: 29970565 DOI: 10.21873/anticanres.12728

11122 Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T. Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel. Biomacromolecules 2018 19(8):3280-3290 PubMed ID: 29985587 DOI: 10.1021/acs.biomac.8b00588

11186 Kawasaki K, Okuda-Hanafusa C, Aoyagi M, Taoka K, Yamamoto N, Muroyama K, Murosaki S, Yamamoto Y. Inhibitory effect of the compounds from the water extract of Curcuma longa on the production of PGE2 and NO in a macrophage cell line stimulated by LPS. Biosci. Biotechnol. Biochem. 2018 82(12):2109-2117 PubMed ID: 30146952 DOI: 10.1080/09168451.2018.1511366

11200 Odkhuu E, Komatsu T, Koide N, Naiki Y, Takeuchi K, Tanaka Y, Tsolmongyn B, Jambalganiin U, Morita N, Yoshida T, Gotoh B, Yokochi T. Sendai virus C protein limits NO production in infected RAW264.7 macrophages. Innate Immun 2018 24(7):430-438 PubMed ID: 30189760 DOI: 10.1177/1753425918796619

11074 Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, Matsumoto Y, Nochi T, Watanabe K, Aso H, Tomioka Y. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation. J. Biol. Chem. 2018 293(26):10186-10201 PubMed ID: 29760187 DOI: 10.1074/jbc.M117.796631

11112 Niino T, Tago K, Yasuda D, Takahashi K, Mashino T, Tamura H, Funakoshi-Tago M. A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis. Biochem. Pharmacol. 2018 155:182-197 PubMed ID: 29940171 DOI: 10.1016/j.bcp.2018.06.021

11249 Kamiya T, Tanimoto Y, Fujii N, Negishi T, Suzuki T, Hatano T, Arimoto-Kobayashi S. 2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae. Food Chem. Toxicol. 2018 PubMed ID: 30316843 DOI: 10.1016/j.fct.2018.10.028

11493 Katsumata Y, Kanzaki H, Honda Y, Tanaka T, Yamaguchi Y, Itohiya K, Fukaya S, Miyamoto Y, Narimiya T, Wada S, Nakamura Y. Single Local Injection of Epigallocatechin Gallate-Modified Gelatin Attenuates Bone Resorption and Orthodontic Tooth Movement in Mice. Polymers (Basel) 2018 10(12) PubMed ID: 30961309 DOI: 10.3390/polym10121384

11349 Sugiyama Y, Hiraiwa Y, Hagiya Y, Nakajima M, Tanaka T, Ogura SI. 5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages. BMC Immunol. 2018 PubMed ID: 30567499 DOI: 10.1186/s12865-018-0277-5

4441 Seisho Azuma, Yoshinobu Murakami, Eiko Azuma, Kimiye Baba, Masahiko Taniguchi Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels Trends in Immunotherapy 2018 2 DOI: 10.24294/ti.v2.i2.844

4324 Quan H, Kim Y, Park HC, Yang HC. Effects of phosphatidylserine-containing supported lipid bilayers on the polarization of macrophages. J Biomed Mater Res A 2018 PubMed ID: 29781181 DOI: 10.1002/jbm.a.36454

4325 Hoshi K, Yamazaki T, Yoshikawa C, Tsugawa W, Ikebukuro K, Sode K. Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production. Int J Nanomedicine 2018 PubMed ID: 30122920 DOI: 10.2147/IJN.S166259

4326 Saiki P, Nakajima Y, Van Griensven LJLD, Miyazaki K. Real-time monitoring of IL-6 and IL-10 reporter expression for anti-inflammation activity in live RAW 264.7 cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30301531 DOI: 10.1016/j.bbrc.2018.09.173

4327 Abe T, Sumi K, Kunimatsu R, Oki N, Tsuka Y, Nakajima K, Tanimoto K. Dynamic imaging of the effect of mesenchymal stem cells on osteoclast precursor cell chemotaxis for bone defects in the mouse skull. J Dent Sci 2018 PubMed ID: 30895145 DOI: 10.1016/j.jds.2018.08.001

4328 Sumi K, Abe T, Kunimatsu R, Oki N, Tsuka Y, Awada T, Nakajima K, Ando K, Tanimoto K. The effect of mesenchymal stem cells on chemotaxis of osteoclast precursor cells. J Oral Sci 2018 PubMed ID: 29925706 DOI: 10.2334/josnusd.17-0187

4329 Kajita T, Ariyoshi W, Okinaga T, Mitsugi S, Tominaga K, Nishihara T. Mechanisms involved in enhancement of osteoclast formation by activin-A. J. Cell. Biochem. 2018 PubMed ID: 29737562 DOI: 10.1002/jcb.26906

4330 Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways. Int. Immunopharmacol. 2018 PubMed ID: 30005227 DOI: 10.1016/j.intimp.2018.06.021

4331 El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S. New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella. Fitoterapia 2018 PubMed ID: 29729401 DOI: 10.1016/j.fitote.2018.05.001

4332 Tanaka M, Kishimoto Y, Sasaki M, Sato A, Kamiya T, Kondo K, Iida K. Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways. Oxid Med Cell Longev 2018 PubMed ID: 30533177 DOI: 10.1155/2018/9364364

4333 Kawabata K, Baba N, Sakano T, Hamano Y, Taira S, Tamura A, Baba S, Natsume M, Ishii T, Murakami S, Ohigashi H. Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. Biosci. Biotechnol. Biochem. 2018 PubMed ID: 29165050 DOI: 10.1080/09168451.2017.1401916

4334 Fukai E, Sato H, Watanabe M, Nakae D, Totsuka Y. Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes. Cancer Sci. 2018 PubMed ID: 29444368 DOI: 10.1111/cas.13534

4335 Hussain Z, Uyama T, Kawai K, Binte Mustafiz SS, Tsuboi K, Araki N, Ueda N. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Biochim Biophys Acta Mol Cell Biol Lipids 2018 PubMed ID: 29447909 DOI: 10.1016/j.bbalip.2018.02.002

4336 Takahashi S, Sakamaki M, Ferdousi F, Yoshida M, Demura M, Watanabe MM, Isoda H. Ethanol Extract of Aurantiochytrium mangrovei 18W-13a Strain Possesses Anti-inflammatory Effects on Murine Macrophage RAW264 Cells. Front Physiol 2018 PubMed ID: 30319432 DOI: 10.3389/fphys.2018.01205

4496 Su YW, Chim SM, Zhou L, Hassanshahi M, Chung R, Fan C, Song Y, Foster BK, Prestidge CA, Peymanfar Y, Tang Q, Butler LM, Gronthos S, Chen D, Xie Y, Chen L, Zhou XF, Xu J, Xian CJ. Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats. Bone 2018 116:232-247 PubMed ID: 30125729 DOI: 10.1016/j.bone.2018.08.010

4497 Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka T, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N. Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells. Int J Nanomedicine 2018 13:6079-6088 PubMed ID: 30323595 DOI: 10.2147/IJN.S172493

4498 Momozane T, Kawamura T, Itoh Y, Sanosaka M, Sasaki T, Kanzaki R, Ose N, Funaki S, Shintani Y, Minami M, Okumura M, Takemori H. Carnosol suppresses interleukin-6 production in mouse lungs injured by ischemia-reperfusion operation and in RAW264.7 macrophages treated with lipopolysaccharide. Biochem. Cell Biol. 2018 96(6):769-776 PubMed ID: 29958095 DOI: 10.1139/bcb-2017-0339

4499 Choodej S, Pudhom K, Mitsunaga T. Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. Planta Med. 2018 84(5):329-335 PubMed ID: 28962049 DOI: 10.1055/s-0043-120115

14915 Komatsu W, Kishi H, Yagasaki K, Ohhira S. Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species Eur J Pharmacol 2018 833:411-424 PubMed ID: 29932926 DOI: 10.1016/j.ejphar.2018.06.023

15294 Pavillon N, Hobro AJ, Akira S, Smith NI. Noninvasive detection of macrophage activation with single-cell resolution through machine learning Proc Natl Acad Sci U S A 2018 115(12):E2676-E2685 PubMed ID: 29511099 DOI: 10.1073/pnas.1711872115

7036 Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y. Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Sci Rep 2017 7:44754 PubMed ID: 28303974 DOI: 10.1038/srep44754

9723 Iwazaki K, Tanaka T, Hozumi Y, Okada M, Tsuchiya R, Iseki K, Topham MK, Kawamae K, Takagi M, Goto K. DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions. J. Cell. Physiol. 2017 232:617-624 PubMed ID: 27312515 DOI: 10.1002/jcp.25461

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9964 Shirasugi M, Nishioka K, Yamamoto T, Nakaya T, Kanamura N. Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. Biochem. Biophys. Res. Commun. 2017 482:1122-1128 PubMed ID: 27914813 DOI: 10.1016/j.bbrc.2016.11.168

10001 Quan H, Park HC, Kim Y, Yang HC. Modulation of the anti-inflammatory effects of phosphatidylserine-containing liposomes by PEGylation. J Biomed Mater Res A 2017 105:1479-1486 PubMed ID: 27998010 DOI: 10.1002/jbm.a.35981

10074 Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F. Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metab. Clin. Exp. 2017 69:157-170 PubMed ID: 28285646 DOI: 10.1016/j.metabol.2017.01.006

10085 Ariyoshi W, Okinaga T, Chaweewannakorn W, Akifusa S, Nisihara T. Mechanisms involved in enhancement of matrix metalloproteinase-9 expression in macrophages by interleukin-33. J. Cell. Physiol. 2017 232:3481-3495 PubMed ID: 28105703 DOI: 10.1002/jcp.25809

10122 Taniguchi M, Ochiai A, Toyoda R, Sato T, Saitoh E, Kato T, Tanaka T. Effects of arginine and leucine substitutions on anti-endotoxic activities and mechanisms of action of cationic and amphipathic antimicrobial octadecapeptide from rice α-amylase. J. Pept. Sci. 2017 23:252-260 PubMed ID: 28185358 DOI: 10.1002/psc.2983

10165 Takeuchi T, Sugimoto A, Imazato N, Tamura M, Nakatani S, Kobata K, Arata Y. Glucosamine Suppresses Osteoclast Differentiation through the Modulation of Glycosylation Including O-GlcNAcylation. Biol. Pharm. Bull. 2017 40:352-356 PubMed ID: 28250278 DOI: 10.1248/bpb.b16-00877

10169 Zhang J, Hiromoto S, Yamazaki T, Huang H, Jia G, Li H, Yuan G. Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method. Mater Sci Eng C Mater Biol Appl 2017 75:1178-1183 PubMed ID: 28415404 DOI: 10.1016/j.msec.2017.02.126

10190 Ichimura K, Shimizu T, Matsumoto A, Hirai S, Yokoyama E, Takeuchi H, Yahiro K, Noda M. Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157. Microbiologyopen 2017 6: PubMed ID: 28294553 DOI: 10.1002/mbo3.461

10215 Yamagata Y, Tomioka H, Sakamoto K, Sato K, Harada H, Ikeda T, Kayamori K. CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma. J. Oral Maxillofac. Surg. 2017 75:2144-2153 PubMed ID: 28399391 DOI: 10.1016/j.joms.2017.03.009

10230 Hashiguchi A, Hitachi K, Zhu W, Tian J, Tsuchida K, Komatsu S. Mung bean (Vigna radiata (L.)) coat extract modulates macrophage functions to enhance antigen presentation: A proteomic study. J Proteomics 2017 161:26-37 PubMed ID: 28373035 DOI: 10.1016/j.jprot.2017.03.025

10285 Fereig RM, Kuroda Y, Terkawi MA, Mahmoud ME, Nishikawa Y. Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice. PLoS ONE 2017 12:e0176324 PubMed ID: 28448521 DOI: 10.1371/journal.pone.0176324

10288 Kato T, Toyooka T, Ibuki Y, Masuda S, Watanabe M, Totsuka Y. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ 2017 39:12 PubMed ID: 28469735 DOI: 10.1186/s41021-017-0075-y

10335 Wu S, Yano S, Chen J, Hisanaga A, Sakao K, He X, He J, Hou DX. Polyphenols from Lonicera caerulea L. Berry Inhibit LPS-Induced Inflammation through Dual Modulation of Inflammatory and Antioxidant Mediators. J. Agric. Food Chem. 2017 65:5133-5141 PubMed ID: 28573848 DOI: 10.1021/acs.jafc.7b01599

10380 Murata K, Motomura Y, Tanaka T, Kanno S, Yano T, Onimaru M, Shimoyama A, Nishio H, Sakai Y, Oh-Hora M, Hara H, Fukase K, Takada H, Masuda S, Ohga S, Yamasaki S, Hara T. Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease. Clin. Exp. Immunol. 2017 190:54-67 PubMed ID: 28640392 DOI: 10.1111/cei.13002

10551 Saiki P, Kawano Y, Van Griensven LJLD, Miyazaki K. The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content. Food Funct 2017 8:4150-4158 PubMed ID: 29022634 DOI: 10.1039/c7fo01172e

10704 Hanagata N, Li X, Chen MH, Li J, Hattori S. Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities. Int J Nanomedicine 2017 13:43-62 PubMed ID: 29317815 DOI: 10.2147/IJN.S152141

10915 Effect of Particle Size of Gold Nanoparticles on Matrix Metalloprotease Inhibition, Cytotoxicity and Genotoxicity Journal of Biomaterials and Tissue Engineering, 2017 7, 139-146 DOI: 10.1166/jbt.2017.1555

10949 Effect of 50-Hz Sinusoidal Magnetic Field on the Production of Superoxide Anion and the Expression of Heat-shock Protein 70 in RAW264 Cells International Journal of Chemistry 2017 9 DOI: 10.5539/ijc.v9n2p23

4526 Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017 818, 7-16 PubMed ID: 28477879 DOI: 10.1016/j.mrgentox.2017.04.002

6471 Horigome S, Yoshida I, Ito S, Inohana S, Fushimi K, Nagai T, Yamaguchi A, Fujita K, Satoyama T, Katsuda SI, Suzuki S, Watai M, Hirose N, Mitsue T, Shirakawa H, Komai M. Inhibitory effects of Kaempferia parviflora extract on monocyte adhesion and cellular reactive oxygen species production in human umbilical vein endothelial cells. Eur J Nutr 2017 56(3):949-964 PubMed ID: 26704713 DOI: 10.1007/s00394-015-1141-5

9460 Nan Ma, Di Yang, Hirohiko Okamura, Jumpei Teramachi, Tomokazu Hasegawa, Lihong Qiu, Tatsuji Haneji Involvement of interleukin‑23 Induced by Porphyromonas Endodontalis Lipopolysaccharide in Osteoclastogenesis Mol Med Rep 2017 15(2):559-566 PubMed ID: 28000855 DOI: 10.3892/mmr.2016.6041

10050 Ha-Eun Yang, Yongjia Li, Akira Nishimura, Huei-Fen Jheng, Ana Yuliana, Ryuji Kitano-Ohue, Wataru Nomura, Nobuyuki Takahashi, Chu-Sook Kim, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada, Tsuyoshi Goto Synthesized Enone Fatty Acids Resembling Metabolites From Gut Microbiota Suppress Macrophage-Mediated Inflammation in Adipocytes Mol Nutr Food Res 2017 Oct;61(10) PubMed ID: 28544341 DOI: 10.1002/mnfr.201700064

10076 Yusuke Kono, Taketo Nakai, Hitomi Taguchi, Takuya Fujita Development of Magnetic Anionic Liposome/Atelocollagen Complexes for Efficient Magnetic Drug Targeting Drug Deliv 2017 24(1):1740-1749 PubMed ID: 29141461 DOI: 10.1080/10717544.2017.1402219

12320 Masayori Hagimori, Eri Hatabe, Kohei Sano, Hirotaka Miyazaki, Hitoshi Sasaki, Hideo Saji, Takahiro Mukai An Activatable Fluorescent γ-Polyglutamic Acid Complex for Sentinel Lymph Node Imaging Biol Pharm Bull 2017 40(3):297-302 PubMed ID: 28250270 DOI: 10.1248/bpb.b16-00773

14213 Into T, Horie T, Inomata M, Gohda J, Inoue JI, Murakami Y, Niida S. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88 Sci Rep 2017 7(1):1009 PubMed ID: 28432355 DOI: 10.1038/s41598-017-01246-w

14216 Horiuchi T, Sakata N, Narumi Y, Kimura T, Hayashi T, Nagano K, Liu K, Nishibori M, Tsukita S, Yamada T, Katagiri H, Shirakawa R, Horiuchi H. Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity J Biol Chem 2017 292(20):8436-8446 PubMed ID: 28373282 DOI: 10.1074/jbc.M116.769380

14220 Wang J, Ayano E, Maitani Y, Kanazawa H. Tunable Surface Properties of Temperature-Responsive Polymer-Modified Liposomes Induce Faster Cellular Uptake ACS Omega 2017 ;2(1):316-325 PubMed ID: 31457232 DOI: 10.1021/acsomega.6b00342

14255 Komatsu W, Itoh K, Akutsu S, Kishi H, Ohhira S. Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-κB and p38 signaling pathways Biosci Biotechnol Biochem 2017 1956-1966 PubMed ID: 28812425 DOI: 10.1080/09168451.2017.1362973

14379 Okabe I, Kikuchi T, Mogi M, Takeda H, Aino M, Kamiya Y, Fujimura T, Goto H, Okada K, Hasegawa Y, Noguchi T, Mitani A. IL-15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis J Cell Biochem 2017 118(4):739-747 PubMed ID: 27608420 DOI: 10.1002/jcb.25726

14456 Yokota S, Chosa N, Kyakumoto S, Kimura H, Ibi M, Kamo M, Satoh K, Ishisaki A. ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint Int J Mol Med 2017 39(4):799-808 PubMed ID: 28259960 DOI: 10.3892/ijmm.2017.2896

14479 Nishina A, Shimizu K, Koketsu M, Ninomiya M, Sato D, Suzuki T, Hayakawa S, Kimura H. 5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing I κ B α-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages Evid Based Complement Alternat Med 2017 7898973 PubMed ID: 28539967 DOI: 10.1155/2017/7898973

14480 Li G, Miura K, Kuno M. Extracellular phosphates enhance activities of voltage-gated proton channels and production of reactive oxygen species in murine osteoclast-like cells Pflugers Arch 2017 469(2):279-292 PubMed ID: 27999941 DOI: 10.1007/s00424-016-1931-5

14565 Igeta K, Kuwamura Y, Horiuchi N, Nozaki K, Shiraishi D, Aizawa M, Hashimoto K, Yamashita K, Nagai A. Morphological and functional changes in RAW264 macrophage-like cells in response to a hydrated layer of carbonate-substituted hydroxyapatite J Biomed Mater Res A 2017 105(4):1063-1070 PubMed ID: 28085214 DOI: 10.1002/jbm.a.35997

14570 Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages Inflammation 2017 40(6):1933-1943 PubMed ID: 28766178 DOI: 10.1007/s10753-017-0634-1

14571 Takakuwa S, Mizuno N, Takano T, Asakawa S, Sato T, Hiratsuka M, Hirasawa N. Down-regulation of Na +/H + exchanger 1 by Toll-like receptor stimulation in macrophages Immunobiology 2017 222(2):176-182 PubMed ID: 27771174 DOI: 10.1016/j.imbio.2016.10.005

14572 Kanaoka Y, Koga M, Sugiyama K, Ohishi K, Kataoka Y, Yamauchi A. Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through α 7 nAChR in macrophages Toxicology 2017 380:62-7 PubMed ID: 28202387 DOI: 10.1016/j.tox.2017.02.006

14656 Tanaka KI, Sugizaki T, Kanda Y, Tamura F, Niino T, Kawahara M Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury Sci Rep 2017 7:42813 PubMed ID: 28205623 DOI: 10.1038/srep42813

14714 Ikeda Y, Kawai K, Ikawa A, Kawamoto K, Egami Y, Araki N. Rac1 switching at the right time and location is essential for Fcγ receptor-mediated phagosome formation J Cell Sci 2017 130(15):2530-2540 PubMed ID: 28600322 DOI: 10.1242/jcs.201749

14725 Minegishi S, Yumura A, Miyoshi H, Negi S, Taketani S, Motterlini R, Foresti R, Kano K, Kitagishi H. Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model Complexes J Am Chem Soc 2017 139(16):5984-5991 PubMed ID: 28388069 DOI: 10.1021/jacs.7b02229

14773 Yokota H, Tsuzuki A, Shimada Y, Imai A, Utsumi D, Tsukahara T, Matsumoto M, Amagase K, Iwata K, Nakamura A, Yabe-Nishimura C, Kato S. NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis J Pharmacol Exp Ther 2017 360(1):192-200 PubMed ID: 27754929 DOI: 10.1124/jpet.116.235580

15301 Hayashi K, Sato Y, Maruoka H, Sakamoto W, Yogo T. Organic-Inorganic Hybrid Nanoparticles for Tracking the Same Cells Seamlessly at the Cellular, Tissue, and Whole Body Levels ACS Biomater Sci Eng 2017 3(6):1129-1135 PubMed ID: 33429587 DOI: 10.1021/acsbiomaterials.7b00181

7077 Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K. Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. Sci Rep 2016 6:23097 PubMed ID: 26975571 DOI: 10.1038/srep23097

7094 Ryohei Hamaguchi, Yukihiro Kuroda A Novel Biomarker for Cellular Toxicity and Phospholipid Accumulation by Cationic Amphiphilic Drugs. Chromatography 2016 37:35-38 DOI: 10.15583/jpchrom.2015.033

7119 Taniguchi M, Ochiai A, Matsushima K, Tajima K, Kato T, Saitoh E, Tanaka T. Endotoxin-neutralizing activity and mechanism of action of a cationic α-helical antimicrobial octadecapeptide derived from α-amylase of rice. Peptides 2016 75:101-8 PubMed ID: 26643956 DOI: 10.1016/j.peptides.2015.11.006

7148 Ohta T, Kusano K, Ido A, Miura C, Miura T. Silkrose: A novel acidic polysaccharide from the silkmoth that can stimulate the innate immune response. Carbohydr Polym 2016 136:995-1001 PubMed ID: 26572439 DOI: 10.1016/j.carbpol.2015.09.070

7157 Higuchi H, Shoji T, Murase Y, Iijima S, Nishijima K. Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Biosci. Biotechnol. Biochem. 2016 80:501-9 PubMed ID: 26540411 DOI: 10.1080/09168451.2015.1104238

7230 Takayama S, Hashimoto K, Kokubu E, Taniguchi M, Tajima K, Ochiai A, Saitoh E, Saito A, Ishihara K, Kato T. Inhibitory effects of a novel cationic dodecapeptide [CL(14-25)] derived from cyanate lyase of rice on endotoxic activities of LPSs from Escherichia coli and periodontopathic Aggregatibacter actinomycetemcomitans. Microb. Pathog. 2016 94:2-11 PubMed ID: 26318142 DOI: 10.1016/j.micpath.2015.08.011

7469 Hashimoto M, Sasaki J, Imazato S. Investigation of the cytotoxicity of aluminum oxide nanoparticles and nanowires and their localization in L929 fibroblasts and RAW264 macrophages. J. Biomed. Mater. Res. Part B Appl. Biomater. 2016 104:241-52 PubMed ID: 25715832 DOI: 10.1002/jbm.b.33377

9520 Lu Y, Cao L, Egami Y, Kawai K, Araki N. Cofilin contributes to phagocytosis of IgG-opsonized particles but not non-opsonized particles in RAW264 macrophages. Microscopy (Oxf) 2016 65:233-42 PubMed ID: 26754560 DOI: 10.1093/jmicro/dfv376

9550 Takeuchi T, Nagasaka M, Shimizu M, Tamura M, Arata Y. N-acetylglucosamine suppresses osteoclastogenesis in part through the promotion of O-GlcNAcylation. Bone Rep 2016 5:15-21 PubMed ID: 28326343 DOI: 10.1016/j.bonr.2016.02.001

9554 Kuno M, Li G, Moriura Y, Hino Y, Kawawaki J, Sakai H. Acid-inducible proton influx currents in the plasma membrane of murine osteoclast-like cells. Pflugers Arch. 2016 468:837-47 PubMed ID: 26843093 DOI: 10.1007/s00424-016-1796-7

9564 Wada T, Sunaga H, Miyata K, Shirasaki H, Uchiyama Y, Shimba S. Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation of Socs3 Gene Expression. J. Biol. Chem. 2016 291:7004-16 PubMed ID: 26865635 DOI: 10.1074/jbc.M115.693655

9569 Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine 2016 23:417-28 PubMed ID: 27002412 DOI: 10.1016/j.phymed.2016.01.006

9573 Maeda Y, Echizen K, Oshima H, Yu L, Sakulsak N, Hirose O, Yamada Y, Taniguchi T, Jenkins BJ, Saya H, Oshima M. Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment. Cancer Prev Res (Phila) 2016 9:253-63 PubMed ID: 26888865 DOI: 10.1158/1940-6207.CAPR-15-0315

9607 Sugiyama K, Muroi M, Kinoshita M, Hamada O, Minai Y, Sugita-Konishi Y, Kamata Y, Tanamoto K. NF-κB activation via MyD88-dependent Toll-like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol. J Toxicol Sci 2016 41:273-9 PubMed ID: 26961612 DOI: 10.2131/jts.41.273

9609 Nakabayashi H, Aoyama S, Kawahara M, Nagamune T. Differentiation signalobody: Demonstration of antigen-dependent osteoclast differentiation from a progenitor cell line. J. Biosci. Bioeng. 2016 122:357-63 PubMed ID: 26979343 DOI: 10.1016/j.jbiosc.2016.02.010

9612 Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J. Cell. Physiol. 2016 231:2761-7 PubMed ID: 26989816 DOI: 10.1002/jcp.25385

9673 Okahashi N, Nakata M, Kuwata H, Kawabata S. Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide. Infect. Immun. 2016 84:2042-2050 PubMed ID: 27113357 DOI: 10.1128/IAI.00134-16

9690 Elfeky M, Kaede R, Okamatsu-Ogura Y, Kimura K. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators Inflamm. 2016 2016:5701959 PubMed ID: 27313399 DOI: 10.1155/2016/5701959

9692 Kure A, Nakagawa K, Kondo M, Kato S, Kimura F, Watanabe A, Shoji N, Hatanaka S, Tsushida T, Miyazawa T. Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect. J. Agric. Food Chem. 2016 64:4246-54 PubMed ID: 27170112 DOI: 10.1021/acs.jafc.6b00964

9706 Zhang J, Hiromoto S, Yamazaki T, Niu J, Huang H, Jia G, Li H, Ding W, Yuan G. Effect of macrophages on in vitro corrosion behavior of magnesium alloy. J Biomed Mater Res A 2016 104:2476-87 PubMed ID: 27223576 DOI: 10.1002/jbm.a.35788

9740 Sunarso , Toita R, Tsuru K, Ishikawa K. A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses. J Mater Sci Mater Med 2016 27:127 PubMed ID: 27344451 DOI: 10.1007/s10856-016-5741-2

9747 Arikawa M, Kakinuma Y, Noguchi T, Todaka H, Sato T. Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation. Eur. J. Pharmacol. 2016 789:17-26 PubMed ID: 27373848 DOI: 10.1016/j.ejphar.2016.06.053

9818 Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, Katsumata Y, Makihira S, Kawai T, Taubman MA, Nakamura Y. A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. Sci Rep 2016 6:32259 PubMed ID: 27573075 DOI: 10.1038/srep32259

9882 Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep 2016 6:35930 PubMed ID: 27775020 DOI: 10.1038/srep35930

9922 Yamawaki T, Ito E, Mukai A, Ueno M, Yamada J, Sotozono C, Kinoshita S, Hamuro J. The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells. Invest. Ophthalmol. Vis. Sci. 2016 57:5945-5953 PubMed ID: 27820950 DOI: 10.1167/iovs.16-20604

9969 Domon H, Oda M, Maekawa T, Nagai K, Takeda W, Terao Y. Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. Sci Rep 2016 6:38013 PubMed ID: 27892542 DOI: 10.1038/srep38013

10852 Kejuan Li, Xi Yang, Xuansheng Hu, Chao Han, Zhongfang Lei, Zhenya Zhang In vitro antioxidant, immunomodulatory and anticancer activities of two fractions of aqueous extract from Helicteres angustifolia L. root Journal of the Taiwan Institute of Chemical Engineers 2016 61:75-82 DOI: 10.1016/j.jtice.2015.12.022

10857 Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients Journal of Cosmetics, Dermatological Sciences and Applications 2016 6, 9-18 DOI: 10.4236/jcdsa.2016.61002

10869 Isolation and Biochemical Characterization of Mucus Proteins in Japanese Bunching Onion (Allium fistulosum) Green Leaves Food Science and Technology Research 2016 22 DOI: 10.3136/fstr.22.235

9409 Nobutaka Sato 1, Jiro Ichikawa 1, Masanori Wako, Tetsuro Ohba, Masanori Saito, Hironao Sato, Kensuke Koyama, Tetsuo Hagino, Jonathan G Schoenecker, Takashi Ando, Hirotaka Haro Thrombin Induced by the Extrinsic Pathway and PAR-1 Regulated Inflammation at the Site of Fracture Repair Bone 2016 83:23-34 PubMed ID: 26475502 DOI: 10.1016/j.bone.2015.10.005

10109 Yusuke Kono, Ayu Iwasaki, Kenta Matsuoka, Takuya Fujita Effect of Mechanical Agitation on Cationic Liposome Transport Across an Unstirred Water Layer in Caco-2 Cells Biol Pharm Bull 2016 39(8):1293-9 PubMed ID: 27476939 DOI: 10.1248/bpb.b16-00050

12622 Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y, Sakamoto T, Nitta T, Kim M, Takahashi N, Yu R, Daiyasu H, Seno S, Matsuda H, Kawada T. Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes Cytokinec 2016 77:107-14 PubMed ID: 26556104 DOI: 10.1016/j.cyto.2015.11.001

12858 Hashimoto M, Kawai K, Kawakami H, Imazato S. Matrix metalloproteases inhibition and biocompatibility of gold and platinum nanoparticles J Biomed Mater Res A 2016 104(1):209-17. PubMed ID: 26282184 DOI: 10.1002/jbm.a.35557

12885 Ichikawa N, Yamashita K, Funakoshi T, Ichihara S, Fukai M, Ogura M, Kobayashi N, Zaitsu M, Yoshida T, Shibasaki S, Koshizuka Y, Tsunetoshi Y, Sato M, Einama T, Ozaki M, Umezawa K, Suzuki T, Todo S. Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease Inflamm Res 2016 65(3):245-60 PubMed ID: 26683259 DOI: 10.1007/s00011-015-0911-0

12936 Hayashida Y, Ikeda Y, Sawada K, Kawai K, Kato T, Kakehi Y, Araki N. Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor Int J Cancer 2016 139(3):700-11 PubMed ID: 26989815 DOI: 10.1002/ijc.30097

12956 Nagahara H, Yamamoto A, Seno T, Obayashi H, Kida T, Nakabayashi A, Kukida Y, Fujioka K, Fujii W, Murakami K, Kohno M, Kawahito Y. Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury Biosci Trends 2016 10(1):47-53. PubMed ID: 26911661 DOI: 10.5582/bst.2016.01027

13985 Nakayama M, Nakamura A, Hondou T, Miyata H. Evaluation of cell viability, DNA single-strand breaks, and nitric oxide production in LPS-stimulated macrophage RAW264 exposed to a 50-Hz magnetic field Int J Radiat Biol 2016 ;92(10):583-9 PubMed ID: 27430265 DOI: 10.1080/09553002.2016.1206224

14099 Yamamoto S, Ohta N, Matsumoto A, Horiguchi Y, Koide M, Fujino Y. Haloperidol Suppresses NF-kappaB to Inhibit Lipopolysaccharide-Induced Pro-Inflammatory Response in RAW 264 Cells Med Sci Monit 2016 22:367-72 PubMed ID: 26842661 DOI: 10.12659/msm.895739

14110 Taki M, Tagami T, Fukushige K, Ozeki T. Fabrication of nanocomposite particles using a two-solution mixing-type spray nozzle for use in an inhaled curcumin formulation Int J Pharm 2016 511(1):104-110 PubMed ID: 27374204 DOI: 10.1016/j.ijpharm.2016.06.134

14164 Yiting Li, Shili Meng, Min Shi, Xuansheng Hu, Yingnan Yang, Zhenya Zhang Bioactivity Evaluation of Crude Polysaccharide from Rice Bran Fermented by Preussia Aemulans and the Changes in its Nutritional Contents Journal of Food Biochemistry 2016 40:664-672 DOI: 10.1111/jfbc.12258

14578 Ito S, Tanaka Y, Oshino R, Okado S, Hori M, Isobe KI. GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation Cell Death Dis 2016 7(5):e2219 PubMed ID: 27171261 DOI: 10.1038/cddis.2016.116

15302 Yuichi Masuda, Chitose Maruyama, Kyuichi Kawabata, Yoshimitsu Hamano, Takayuki Doi Synthesis of (2S,3R,4R)-3,4-dihydroxyarginine and its inhibitory activity against nitric oxide synthase Tetrahedron 2016 72:5602-5611 DOI: 10.1016/j.tet.2016.07.050

7085 Hosokawa T, Tsuchiya Y, Okubo N, Kunimoto T, Minami Y, Fujiwara H, Umemura Y, Koike N, Kubo T, Yagita K. Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells. Acta Histochem Cytochem 2015 48:165-71 PubMed ID: 26855448 DOI: 10.1267/ahc.15025

7137 Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K. Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo. Sci Rep 2015 5:17205 PubMed ID: 26598133 DOI: 10.1038/srep17205

7142 Washio K, Kobayashi M, Saito N, Amagasa M, Kitamura H. Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production through NF-κB Activation in C2C12 Myoblasts. Evid Based Complement Alternat Med 2015 2015:349751 PubMed ID: 26604971 DOI: 10.1155/2015/349751

7221 Sawada Y, Sakamoto Y, Toh M, Ohara N, Hatanaka Y, Naka A, Kishimoto Y, Kondo K, Iida K. Milk-derived peptide Val-Pro-Pro (VPP) inhibits obesity-induced adipose inflammation via an angiotensin-converting enzyme (ACE) dependent cascade. Mol Nutr Food Res 2015 59:2502-10 PubMed ID: 26346532 DOI: 10.1002/mnfr.201500324

7229 Inoue K, Imai Y. Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation. Biochim. Biophys. Acta 2015 1852:2432-41 PubMed ID: 26319416 DOI: 10.1016/j.bbadis.2015.08.018

7274 Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K. IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. J. Clin. Invest. 2015 125:3269-79 PubMed ID: 26193638 DOI: 10.1172/JCI76765

7293 Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y. Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages. Endocrinology 2015 156:3680-94 PubMed ID: 26132918 DOI: 10.1210/EN.2015-1096

7321 Hashimoto M, Sasaki JI, Yamaguchi S, Kawai K, Kawakami H, Iwasaki Y, Imazato S. Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity. J. Dent. Res. 2015 94:1085-91 PubMed ID: 26040283 DOI: 10.1177/0022034515589282

7340 Suzuki N, Takimoto K, Kawashima N. Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions. J Endod 2015 41:1474-9 PubMed ID: 25990199 DOI: 10.1016/j.joen.2015.04.013

7420 Miyazaki T, Miyauchi S, Anada T, Tawada A, Suzuki O. Chondroitin Sulfate-E Binds to Both Osteoactivin and Integrin αVβ3 and Inhibits Osteoclast Differentiation. J. Cell. Biochem. 2015 116:2247-57 PubMed ID: 25820496 DOI: 10.1002/jcb.25175

7448 Takeuchi T, Shimakawa G, Tamura M, Yokosawa H, Arata Y. ISG15 regulates RANKL-induced osteoclastogenic differentiation of RAW264 cells. Biol. Pharm. Bull. 2015 38:482-6 PubMed ID: 25757932 DOI: 10.1248/bpb.b14-00410

7451 Hashimoto M, Imazato S. Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages. Dent Mater 2015 31:556-64 PubMed ID: 25749564 DOI: 10.1016/j.dental.2015.02.009

7467 Kawabata K, Kato Y, Sakano T, Baba N, Hagiwara K, Tamura A, Baba S, Natsume M, Ohigashi H. Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis. Biosci. Biotechnol. Biochem. 2015 79:799-807 PubMed ID: 25721815 DOI: 10.1080/09168451.2015.1006566

7492 Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M. Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury. Am. J. Physiol. Renal Physiol. 2015 308:F878-87 PubMed ID: 25656369 DOI: 10.1152/ajprenal.00590.2014

7501 Lai YT, Sato M, Ohta S, Akamatsu K, Nakao S, Sakai Y, Ito T. Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique. Colloids Surf B Biointerfaces 2015 127:1-7 PubMed ID: 25635614 DOI: 10.1016/j.colsurfb.2015.01.018

7505 Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages. Biosci. Biotechnol. Biochem. 2015 79:82-7 PubMed ID: 25603813 DOI: 10.1080/09168451.2014.962472

7517 Taniguchi M, Ochiai A, Takahashi K, Nakamichi S, Nomoto T, Saitoh E, Kato T, Tanaka T. Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice. Biopolymers 2015 104:73-83 PubMed ID: 25581614 DOI: 10.1002/bip.22605

7526 F Shima, T Akagi, M Shudo, E Mochizuki, T Tsuda, S Kuwabata M Akashi Interaction between living cells and polymeric particles: potential application of ionic liquid for evaluating the cellular uptake of biodegradable polymeric particles composed of poly(amino acid). Polymer Journal 2015 47:631-638 DOI: 10.1038/pj.2015.40

6343 Uto T, Tung NH, Taniyama R, Miyanowaki T, Morinaga O, Shoyama Y. Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa. Phytother Res 2015 29(12):1956-63 PubMed ID: 26463105 DOI: 10.1002/ptr.5490

6621 Koyama T, Kamemura K. Global increase in O-linked N-acetylglucosamine modification promotes osteoblast differentiation. Exp Cell Res 2015 338(2):194-202 PubMed ID: 26302267 DOI: 10.1016/j.yexcr.2015.08.009

9365 Akio Watanabe, Momochika Kumagai, Takashi Mishima, Junya Ito, Yurika Otoki, Teppei Harada, Tsuyoshi Kato, Mikihiko Yoshida, Misora Suzuki, Izumi Yoshida, Kazuhiro Fujita, Masatoshi Watai, Kiyotaka Nakagawa, Teruo Miyazawa Toddaculin, Isolated From of Toddalia Asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells PLoS One 2015 10(5):e0127158 PubMed ID: 25993011 DOI: 10.1371/journal.pone.0127158

9378 R Toita, Sunarso, A N Rashid, K Tsuru, K Ishikawa Modulation of the Osteoconductive Property and Immune Response of Poly(ether Ether Ketone) by Modification With Calcium Ions J Mater Chem B 2015 3(44):8738-8746 PubMed ID: 32262731 DOI: 10.1039/c5tb01679g

10173 Yao-Tong Lai, Seiichi Ohta, Kazuki Akamatsu, Shin-Ichi Nakao, Yasuyuki Sakai, Taichi Ito Size-dependent Interaction of Cells and Hemoglobin-Albumin Based Oxygen Carriers Prepared Using the SPG Membrane Emulsification Technique Biotechnol Prog . 2015 31(6):1676-84 PubMed ID: 26399378 DOI: 10.1002/btpr.2170

10195 Akihiko Nagao, Takashi Maoka, Hiroshi Ono, Eiichi Kotake-Nara, Miyuki Kobayashi, Mie Tomita A 3-hydroxy β-End Group in Xanthophylls Is Preferentially Oxidized to a 3-oxo ε-End Group in Mammals J Lipid Res 2015 56(2):449-62 PubMed ID: 25502844 DOI: 10.1194/jlr.P055459

12234 Masayori Hagimori, Naoko Mizuyama, Yoshinori Tominaga, Takahiro Mukai,Hideo Saji A low-molecular-weight fluorescent sensor with Zn2+ dependent bathochromic shift of emission wavelength and its imaging in living cells Dyes and Pigments 2015 113:205-209 DOI: 10.1016/j.dyepig.2014.07.032

12237 Shiro Kato, Yuki Masuda, Morichika Konishi, Tadao Oikawa Enantioselective analysis of D- and L-amino acids from mouse macrophages using high performance liquid chromatography J Pharm Biomed Anal 2015 116:101-4 PubMed ID: 25982753 DOI: 10.1016/j.jpba.2015.04.028

12245 Takashi Ando, Takayuki Komatsu, Yoshikazu Naiki, Takashi Yokochi, Daisuke Watanabe, Naoki Koide Pretreatment of LPS inhibits IFN-β-induced STAT1 phosphorylation through SOCS3 induced by LPS Biomed Pharmacother 2015 76:1-5 PubMed ID: 26653542 DOI: 10.1016/j.biopha.2015.10.019

12252 Yoshiro Kato, Hideki Kamiya, Naoki Koide, Erdenezaya Odkhuu, Takayuki Komatsu, Atsuko Watarai, Masaki Kondo, Koichi Kato, Jiro Nakamura, Takashi Yokochi Irbesartan attenuates production of high-mobility group box 1 in response to lipopolysaccharide via downregulation of interferon-β production Int Immunopharmacol 2015 26(1):97-102 PubMed ID: 25817178 DOI: 10.1016/j.intimp.2015.03.015

12259 Shusong Wu, Xi He, Xiaosong Wu, Si Qin, Jianhua He, Shirui Zhang, De-Xing Hou Inhibitory effects of blue honeysuckle (Lonicera caerulea L) on adjuvant-induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects J Functional Foods 2015 17:514-515 DOI: 10.1016/j.jff.2015.06.007

13961 Fujioka K, Kishida T, Ejima A, Yamamoto K, Fujii W, Murakami K, Seno T, Yamamoto A, Kohno M, Oda R, Yamamoto T, Fujiwara H, Kawahito Y, Mazda O. Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10 Biochem Biophys Res Commun 2015 456(3):785-91 PubMed ID: 25514036 DOI: 10.1016/j.bbrc.2014.12.040

14465 Okinaga T, Ariyoshi W, Nishihara T. Aggregatibacter actinomycetemcomitans Invasion Induces Interleukin-1β Production Through Reactive Oxygen Species and Cathepsin B J Interferon Cytokine Res 2015 35(6):431-40 PubMed ID: 25789553 DOI: 10.1089/jir.2014.0127

14969 Kiyomiya H, Ariyoshi W, Okinaga T, Kaneuji T, Mitsugi S, Sakurai T, Habu M, Yoshioka I, Tominaga K, Nishihara T. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression Biochem Biophys Res Commun 2015 460(2):320-6 PubMed ID: 25795135 DOI: 10.1016/j.bbrc.2015.03.033

14983 He YM, Zhu S, Ge YW, Kazuma K, Zou K, Cai SQ, Komatsu K. The anti-inflammatory secoiridoid glycosides from gentianae scabrae radix: the root and rhizome of Gentiana scabra J Nat Med 2015 69(3):303-12 PubMed ID: 25750086 DOI: 10.1007/s11418-015-0894-8

14991 Komiya M, Fujii G, Miyamoto S, Takahashi M, Ishigamori R, Onuma W, Ishino K, Totsuka Y, Fujimoto K, Mutoh M. Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice Cancer Sci 2015 106(11):1499-505 PubMed ID: 26310859 DOI: 10.1111/cas.12801

15020 Mori K, Ouchi K, Hirasawa N. The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages Int J Med Mushrooms 2015 17(7):609-18 PubMed ID: 26559695 DOI: 10.1615/intjmedmushrooms.v17.i7.10

15021 Tan H, Ashour A, Katakura Y, Shimizu K. A structure-activity relationship study on antiosteoclastogenesis effect of triterpenoids from the leaves of loquat (Eriobotrya japonica) Phytomedicine 2015 22(4):498-503 PubMed ID: 25925972 DOI: 10.1016/j.phymed.2015.03.002

15028 Inaba H, Yoshigai E, Okuyama T, Murakoshi M, Sugiyama K, Nishino H, Nishizawa M. Antipyretic analgesic drugs have different mechanisms for regulation of the expression of inducible nitric oxide synthase in hepatocytes and macrophages Nitric Oxide 2015 44:61-70 PubMed ID: 25499030 DOI: 10.1016/j.niox.2014.12.001

15148 Kojima C, Kameyama R, Yamada M, Ichikawa M, Waku T, Handa A, Tanaka N. Ovalbumin Delivery by Guanidine-Terminated Dendrimers Bearing an Amyloid-Promoting Peptide via Nanoparticle Formulation Bioconjug Chem 2015 26(8):1804-10 PubMed ID: 26186179 DOI: 10.1021/acs.bioconjchem.5b00325

13891 Nakamura R, Kayamori K, Oue E, Sakamoto K, Harada K, Yamaguchi A. Transforming growth factor-β synthesized by stromal cells and cancer cells participates in bone resorption induced by oral squamous cell carcinoma Biochem Biophys Res Commun 2015 458(4):777-82 PubMed ID: 25681764 DOI: 10.1016/j.bbrc.2015.02.013

15208 Wang Q, Yokoo H, Takashina M, Sakata K, Ohashi W, Abedelzaher LA, Imaizumi T, Sakamoto T, Hattori K, Matsuda N, Hattori Y. Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages Crit Care Med 2015 43(11):e508-20 PubMed ID: 26468714 DOI: 10.1097/CCM.0000000000001269

15255 Asakawa S, Kishimoto Y, Takano T, Okita K, Takakuwa S, Sato T, Hiratsuka M, Takeuchi O, Hirasawa N. Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability PLoS One 2015 10(3):e0119428 PubMed ID: 25742007 DOI: 10.1371/journal.pone.0119428

15444 Oka H, Kitagawa M, Takata T. F-spondin inhibits differentiation of clastic precursors via lipoprotein receptor-related protein 8 (LRP8) J Periodontol 2015 86(3):465-72 PubMed ID: 25299387 DOI: 10.1902/jop.2014.140419

15446 Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N. Specific biological responses of the synovial membrane to carbon nanotubes Sci Rep 2015 5:14314 PubMed ID: 26388047 DOI: 10.1038/srep14314

15305 Oh-Hashi K, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, Ishigaki S, Sobue G, Kiuchi K. Transcriptional and post-transcriptional regulation of transmembrane protein 132A Mol Cell Biochem 2015 405(1-2):291-9 PubMed ID: 25926156 DOI: 10.1007/s11010-015-2419-x

15479 Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy Sci Rep 2015 5:8327 PubMed ID: 25659802 DOI: 10.1038/srep08327

15103 Cuilian Tao, Yufang Zhu, Xianglan Li, Nobutaka Hanagata Binding of CpG oligodeoxynucleotides to mesoporous silica nanoparticles for enhancing delivery efficiency Microporous and Mesoporous Materials 2015 204:91-98 DOI: 10.1016/j.micromeso.2014.11.007

16692 Shimada H, Nakamura Y, Nakanishi T, Tamai I. OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion Biochem Pharmacol 2015 98(4):629-38 PubMed ID: 26474801 DOI: 10.1016/j.bcp.2015.10.009

17440 Tahara Y, Yasuoka J, Sawada S, Sasaki Y, Akiyoshi K. Effective CpG DNA delivery using amphiphilic cycloamylose nanogels Biomater Sci 2015 3(2):256-64 PubMed ID: 26218116 DOI: 10.1039/c4bm00293h

17452 Odkhuu E, Mendjargal A, Koide N, Naiki Y, Komatsu T, Yokochi T. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B Immunobiology 2015 220(1):136-41 PubMed ID: 25172547 DOI: 10.1016/j.imbio.2014.08.010

17457 Odkhuu E, Koide N, Tsolmongyn B, Jambalganiin U, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Involvement of redox balance in in vitro osteoclast formation of RAW 264.7 macrophage cells in response to LPS Innate Immun 2015 21(2):194-202 PubMed ID: 24595208 DOI: 10.1177/1753425914524242

17458 Shoji T, Higuchi H, Zaitsu Y, Nishijima K, Iijima S. Enhanced lentiviral vector production in 293FT cells expressing Siglec-9 Cytotechnology 2015 67(4):593-600 PubMed ID: 24464124 DOI: 10.1007/s10616-013-9679-7

17459 Ando M, Shoji T, Tu W, Higuchi H, Nishijima K, Iijima S. Lectin-dependent localization of cell surface sialic acid-binding lectin Siglec-9 Cytotechnology 2015 67(4):601-8 PubMed ID: 24449467 DOI: 10.1007/s10616-014-9691-6

18289 Jambalganiin U, Tsolmongyn B, Koide N, Odkhuu E, Naiki Y, Komatsu T, Yoshida T, Yokochi T. A novel mechanism for inhibition of lipopolysaccharide-induced proinflammatory cytokine production by valproic acid Int Immunopharmacol 2014 20(1):181-7 PubMed ID: 24631367 DOI: 10.1016/j.intimp.2014.02.032

6334 Itoh T, Tsuchida A, Muramatsu Y, Ninomiya M, Ando M, Tsukamasa Y, Koketsu M. Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes. Anaerobe 2014 27:56-63 PubMed ID: 24699048 DOI: 10.1016/j.anaerobe.2014.03.006

2777 Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, Sakurai K, Nishihara T. The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. J Biol Chem 2014 289(27):19191-203 PubMed ID: 24821724 DOI: 10.1074/jbc.M114.551416

6607 Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y. Constitutive and functional expression of runt-related transcription factor-2 by microglial cells. Neurochem Int 2014 74:24-35 PubMed ID: 24768841 DOI: 10.1016/j.neuint.2014.04.010

9114 Erdenezaya Odkhuu, Takayuki Komatsu, Yoshikazu Naiki, Naoki Koide, Takashi Yokochi Sendai Virus C Protein Inhibits Lipopolysaccharide-Induced Nitric Oxide Production Through Impairing Interferon-β Signaling Int Immunopharmacol 2014 23 (1), 267-72 PubMed ID: 25242386 DOI: 10.1016/j.intimp.2014.09.012

9323 Ran Zhao, Masayoshi Kamon, Kazuichi Sakamoto (–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell Food and Nutrition Sciences 2014 5:107-116 DOI: 10.4236/fns.2014.52014

9348 W Ariyoshi, T Okinaga, C B Knudson, W Knudson, T Nishihara High Molecular Weight Hyaluronic Acid Regulates Osteoclast Formation by Inhibiting Receptor Activator of NF-κB Ligand Through Rho Kinase Osteoarthritis Cartilage 2014 22(1):111-20 PubMed ID: 24185105 DOI: 10.1016/j.joca.2013.10.013

9349 Masanori Hashimoto, Hirokazu Toshima, Tetsu Yonezawa, Koji Kawai, Takashi Narushima, Masayuki Kaga, Kazuhiko Endo Responses of RAW264.7 Macrophages to Water-Dispersible Gold and Silver Nanoparticles Stabilized by Metal-Carbon σ-Bonds J Biomed Mater Res A 2014 102(6):1838-49 PubMed ID: 23784947 DOI: 10.1002/jbm.a.34854

9351 Miki Tadaishi, Yoriko Nishide, Yuko Tousen, Marlena C Kruger, Yoshiko Ishimi Cooperative Effects of Soy Isoflavones and Carotenoids on Osteoclast Formation J Clin Biochem Nutr 2014 54(2):109-15 PubMed ID: 24688220 DOI: 10.3164/jcbn.13-94

12850 Tada R, Koide Y, Yamamuro M, Tanaka R, Hidaka A, Nagao K, Aramaki Y. Maleylated-BSA suppresses lipopolysaccharide-induced IL-6 production by activating the ERK-signaling pathway in murine RAW264.7 cells Int Immunopharmacol 2014 19(1):5-9 PubMed ID: 24406428 DOI: 10.1016/j.intimp.2013.12.027

13737 Masanori Hashimoto, Hirokazu Toshima, Tetsu Yonezawa, Koji Kawai, Masahiro Iijima, Kazuhiko Endo Evaluation of Silver Nanoparticle Toxicity to RAW264.7 Cells in a Three-Dimensional Cell Culture Journal of Biomaterials and Tissue Engineering 2014 4:51-58 DOI: 10.1166/jbt.2014.1141

15027 Dan Zhu, Hongyi Sun, Shuhong Li, Xuansheng Hu, Xi Yuan, Chao Han, Zhenya Zhang Influence of Drying Methods on Antioxidant Activities and Immunomodulatory of Aqueous Extract From Soybean Curd Residue Fermentated by Grifola frondosa International Journal of Biology 2014 7:82-92 DOI: 10.5539/ijb.v7n1p82

15306 Itoh T, Koketsu M, Yokota N, Touho S, Ando M, Tsukamasa Y. Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway Food Chem Toxicol 2014 ;69:330-8 PubMed ID: 24795232 DOI: 10.1016/j.fct.2014.04.019

15307 Daisuke Yamanaka, Katsuya Tajima, Yoshiyuki Adachi, Ken-ichi Ishibashi, Noriko N. Miura, Masuro Motoi, Naohito Ohno Effect of polymeric caffeic acid on antitumour activity and natural killer cell activity in mice Journal of Functional Foods 2014 6:513-522 DOI: 10.1016/j.jff.2013.11.018

15308 Hayashi Y, Kuroda T, Kishimoto H, Wang C, Iwama A, Kimura K. Downregulation of rRNA transcription triggers cell differentiation PLoS One 2014 9(5):e98586 PubMed ID: 24879416 DOI: 10.1371/journal.pone.0098586

15309 Kusunoki H, Taniyama Y, Otsu R, Rakugi H, Morishita R. Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes Hypertens Res 2014 37(6):500-6 PubMed ID: 24621470 DOI: 10.1038/hr.2014.41

15310 Sato S, Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Oh-ishi S, Imaizumi K, Haga S, Hitomi Y, Izawa T, Ohira Y, Ohno H, Kizaki T. Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα ScientificWorldJournal 2014 2014:685854 PubMed ID: 25401152 DOI: 10.1155/2014/685854

15311 Araki N, Ikeda Y, Kato T, Kawai K, Egami Y, Miyake K, Tsurumaki N, Yamaguchi M. Development of an automated fluorescence microscopy system for photomanipulation of genetically encoded photoactivatable proteins (optogenetics) in live cells Microscopy (Oxf) 2014 63(3):255-60 PubMed ID: 24523516 DOI: 10.1093/jmicro/dfu003

15312 Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H. IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages Biochem Biophys Res Commun 2014 451(2):215-21 PubMed ID: 25088998 DOI: 10.1016/j.bbrc.2014.07.096

15313 Seiji GODA, Hiroshi HAYASHI, Yosuke UJII, Osamu TAKEUCHI, Reiko KOMASA, Eisuke DOMAE, Kazuyo YAMAMOTO, Naoyuki MATSUMOTO, Takashi IKEO Fibronectin inhibited RANKL-induced differentiation into osteoclast Journal of Oral Tissue Engineering 2014 11:227-233 DOI: 10.11223/jarde.11.227

15314 Sarntivijai S, Lin Y, Xiang Z, Meehan TF, Diehl AD, Vempati UD, Schürer SC, Pang C, Malone J, Parkinson H, Liu Y, Takatsuki T, Saijo K, Masuya H, Nakamura Y, Brush MH, Haendel MA, Zheng J, Stoeckert CJ, Peters B, Mungall CJ, Carey TE, States DJ, Athey BD, He Y. CLO: The cell line ontology J Biomed Semantics 2014 5:37 PubMed ID: 25852852 DOI: 10.1186/2041-1480-5-37

15315 Suk Hyun Choi, Dong-Seok Kim, Nobuyuki Kozukue, Hyun-Jeong Kim, Yosuke Nishitani, Masashi Mizuno, Carol E. Levin, Mendel Friedman Protein, free amino acid, phenolic, β-carotene, and lycopene content, and antioxidative and cancer cell inhibitory effects of 12 greenhouse-grown commercial cherry tomato varieties Journal of Food Composition and Analysis 2014 34:115-127 DOI: 10.1016/j.jfca.2014.03.005

15316 Xu Y, Ito T, Fushimi S, Takahashi S, Itakura J, Kimura R, Sato M, Mino M, Yoshimura A, Matsukawa A. Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice PLoS One 2014 9(9):e108914 PubMed ID: 25275324 DOI: 10.1371/journal.pone.0108914

15317 Uehara K, Takahashi A, Watanabe M, Nomura Y. Shark protein improves bone mineral density in ovariectomized rats and inhibits osteoclast differentiation Nutrition 2014 30(6):719-25 PubMed ID: 24800672 DOI: 10.1016/j.nut.2013.11.005

15319 Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico MA, Mitsutake K, Tokutomi N, Kai H, Shuto T. Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils J Biol Chem 2014 289(26):18097-109 PubMed ID: 24821721 DOI: 10.1074/jbc.M113.532093

15320 Phyu Phyu Khine Zar, Akiko Morishita, Fumio Hashimoto, Kozue Sakao, Makoto Fujii, Koji Wada, De-Xing Hou Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea Journal of Functional Foods 2014 6:523-533 DOI: 10.1016/j.jff.2013.11.019

15322 Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene J Nat Prod 2014 77(7):1670-7 PubMed ID: 24959987 DOI: 10.1021/np5002016

15323 Kato Y, Kamiya H, Koide N, Odkhuu E, Komatsu T, Dagvadorj J, Watarai A, Kondo M, Kato K, Nakamura J, Yokochi T. Spironolactone inhibits production of proinflammatory mediators in response to lipopolysaccharide via inactivation of nuclear factor-κB Immunopharmacol Immunotoxicol 2014 36(3):237-41 PubMed ID: 24852317 DOI: 10.3109/08923973.2014.921690

7584 T. Atsumi, A. Iwashita, I. Ohtsuka, N. Kakiuchi, Y. Sasaki, M. Mikage, K. Toriizuka Effects of Atractylodis Lanceae Rhizoma on inflammatory mediator production from the RAW264 macrophage cell line J Traditional Medicines 2013 30:124-131 DOI: 10.11339/jtm.30.124

5424 Takeshi KAWAHARA, Daichi NAKAYAMA, Keisuke TODA, Shyuichiro INAGAKI, Katsumi TANAKA, Hisako YASUI Suppressive Effect of Wild Saccharomyces cerevisiae and Saccharomyces paradoxus Strains on Ige Production by Mouse Spleen Cells Food Sci. Technol. Res 2013 19 (6), 1019 – 1027 DOI: 10.3136/fstr.19.1019

6086 Ito S, Tanaka Y, Nishio N, Thanasegaran S, Isobe K. Establishment of self-renewable GM-CSF-dependent immature macrophages in vitro from murine bone marrow. PLoS One 2013 8(10):e76943 PubMed ID: 24124601 DOI: 10.1371/journal.pone.0076943

6326 Horibe K, Nakamichi Y, Uehara S, Nakamura M, Koide M, Kobayashi Y, Takahashi N, Udagawa N. Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis. Immunology 2013 140(3):344-51 PubMed ID: 23826736 DOI: 10.1111/imm.12146

6466 Etoh T, Kim YP, Ohsaki A, Komiyama K, Hayashi M. Inhibitory effect of erythraline on Toll-like receptor signaling pathway in RAW264.7 cells. Biol Pharm Bull 2013 36(8):1363-9 PubMed ID: 23902980 DOI: 10.1248/bpb.b12-00910

6467 Etoh T, Kim YP, Tanaka H, Hayashi M. Anti-inflammatory effect of berkeleyacetal C through the inhibition of interleukin-1 receptor-associated kinase-4 activity. Eur J Pharmacol 2013 698(1-3):435-43 PubMed ID: 23127497 DOI: 10.1016/j.ejphar.2012.10.038

9096 Kyoko Ueda, Ryoko Kawabata, Takashi Irie, Yoshiaki Nakai, Yukinobu Tohya, Takemasa Sakaguchi Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts From Persimmon (Diospyros Kaki) on a Broad Range of Viruses PLoS One 2013 8 (1), e55343 PubMed ID: 23372851 DOI: 10.1371/journal.pone.0055343

9100 Hiroki Ishikawa, Naoki Awano, Toshie Fukui, Hiraku Sasaki, Shigeru Kyuwa The Protective Effects of Lactoferrin Against Murine Norovirus Infection Through Inhibition of Both Viral Attachment and Replication Biochem Biophys Res Commun 2013 434 (4), 791-6 PubMed ID: 23603257 DOI: 10.1016/j.bbrc.2013.04.013

9169 Akari Ishisaka, Kyuichi Kawabata, Satomi Miki, Yuko Shiba, Shoko Minekawa, Tomomi Nishikawa, Rie Mukai, Junji Terao, Yoshichika Kawai Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages PLoS One 2013 8 (11), e80843 PubMed ID: 24260490 DOI: 10.1371/journal.pone.0080843

9256 Masanori Hashimoto, Hirokazu Toshima, Tetsu Yonezawa, Koji Kawai, Takashi Narushima, Masayuki Kaga, Kazuhiko Endo Micromorphological Cellular Responses of MC3T3-E1 and RAW264.7 After Exposure to Water-Dispersible Silver Nanoparticles Stabilized by Metal-Carbon σ-Bonds Dent Mater J 2013 32(5):725-33 PubMed ID: 24088827 DOI: 10.4012/dmj.2012-203

9359 Yuriko Furuya, Atsushi Inagaki, Masud Khan, Kaoru Mori, Josef M Penninger, Midori Nakamura, Nobuyuki Udagawa, Kazuhiro Aoki, Keiichi Ohya, Kohji Uchida, Hisataka Yasuda Stimulation of Bone Formation in Cortical Bone of Mice Treated With a Receptor Activator of Nuclear factor-κB Ligand (RANKL)-binding Peptide That Possesses Osteoclastogenesis Inhibitory Activity J Biol Chem 2013 288(8):5562-71 PubMed ID: 23319583 DOI: 10.1074/jbc.M112.426080

9290 Hirohiko Okamura, Di Yang, Kaya Yoshida, Tatsuji Haneji Protein Phosphatase 2A Cα Is Involved in Osteoclastogenesis by Regulating RANKL and OPG Expression in Osteoblasts FEBS Lett 2013 587(1):48-53 PubMed ID: 23183242 DOI: 10.1016/j.febslet.2012.10.041

12258 Kazuhiro Nakaya, Makoto Ayaori, Harumi Uto-Kondo, Grace Megumi Sotherden, Takafumi Nishida, Haruka Katamoto, Yuko Miura, Shunichi Takiguchi, Emi Yakushiji, Maki Iizuka, Masatsune Ogura, Makoto Sasaki, Makiko Yogo, Tomohiro Komatsu, Takeshi Adachi, Chizuko Maruyama, Katsunori Ikewaki Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport Biochim Biophys Acta 2013 1831(8):1402-11 PubMed ID: 23747827 DOI: 10.1016/j.bbalip.2013.05.009

4394 Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K, Ohkubo Y, Hiwatashi D, Takeda T, Komatsu M. Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance. Horm Metab Res 2013 45(7):501-6 PubMed ID: 23508717 DOI: 10.1055/s-0033-1337933

14403 Tsolmongyn B, Koide N, Odkhuu E, Haque A, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation Cell Immunol 2013 282(2):100-5 PubMed ID: 23770718 DOI: 10.1016/j.cellimm.2013.04.011

15324 Rui Tada, Yusuke Koide, Mitsuaki Yamamuro, Akira Hidaka, Koichiro Nagao, Yoichi Negishi, Yukihiko Aramaki Maleylated-BSA induces TNF-α production through the ERK and NF-κB signaling pathways in murine RAW264.7 macrophages Open Journal of Immunology 2013 3:184-189 DOI: 10.4236/oji.2013.34023

15325 Yuka Takasugi, Futoshi Kurai, Issei Kazume, Masaki Otsuka, Yoichi Negishi, Rui Tada, Yukihiko Aramaki Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine Pharmacology & Pharmacy 2013 4:248-254 DOI: 10.4236/pp.2013.42035

15326 Yuko Katao, Hirofumi Sawai, Mika Shishido, Aki Omae, Wen Liao, Kaoru Inami, Naoyuki Matsumoto Augmentation of RANKL-induced osteoclast differentiation by Z-VAD-fmk, a pan-caspase inhibitor Journal of Osaka Dental University 2013 47:41-46 DOI: 10.18905/jodu.47.1_41

15327 Fumiaki Shima, Koshi Kawakami, Takami Akagi, Eiko Mochizuki, Tetsuya Tsuda, Susumu Kuwabata, Mitsuru Akashi Simple Observation of the Interaction between Nanoparticles and Cells by Scanning Electron Microscopy Employing Ionic Liquid Bulletin of the Chemical Society of Japan 2013 86:153-158 DOI: 10.1246/bcsj.20120227

15328 Fujii M, Kawai K, Egami Y, Araki N. Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation Sci Rep 2013 3:2385 PubMed ID: 23924974 DOI: 10.1038/srep02385

15329 Muramatsu S, Tanaka S, Mogushi K, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Nakayama K, Tanaka H, Yamaoka S, Arii S. Visualization of stem cell features in human hepatocellular carcinoma reveals in vivo significance of tumor-host interaction and clinical course Hepatology 2013 58(1):218-28 PubMed ID: 23447025 DOI: 10.1002/hep.26345

15330 Nishimura M, Nii T, Trimova G, Miura S, Umezawa K, Ushiyama A, Kubota T. The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome J Nephropathol 2013 2(2):114-21 PubMed ID: 24475437 DOI: 10.12860/JNP.2013.19

15331 Hiroshi HAYASHI, Yosuke UJII, Seiji GODA, Naoyuki MATSUMOTO Effect of VCAM-1 on the Differentiation into Osteoclast Journal of Oral Tissue Engineering 2013 11:154-162 DOI: 10.11223/jarde.11.154

15332 Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi H, Yamaji R, Inui H, Nakano Y, Yoshikawa T. Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression J Gastroenterol 2013 48(8):897-909 PubMed ID: 23188093 DOI: 10.1007/s00535-012-0719-4

15333 Tatsuya Murakami, Masashi Nakatani, Masahiro Kokubo, Hirotaka Nakatsuji, Mami Inada, Hiroshi Imahori, Masako Yudasaka, Sumio Iijima, Kunihiro Tsuchida Mechanism of Cell Interactions with Water-Dispersed Carbon Nanohorns Nanoscience and Nanotechnology Letters 2013 5:402-407 DOI: 10.1166/nnl.2013.1544

15334 Tanaka K, Ishihara T, Sugizaki T, Kobayashi D, Yamashita Y, Tahara K, Yamakawa N, Iijima K, Mogushi K, Tanaka H, Sato K, Suzuki H, Mizushima T. Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease Nat Commun 2013 4:2686 PubMed ID: 24189798 DOI: 10.1038/ncomms3686

15335 Seikou Kim, Kouichi Yamamoto, Yusuke Nakamura, Yuichi Otoyo, Atsushi Yamatodani A Possible Mechanism of Cisplatin-Induced Tumor Necrosis Factor (TNF)-α Production in Murine Macrophages Pharmacology & Pharmacy 2013 4:146-151 DOI: 10.4236/pp.2013.42021

15336 Tadahiro Etoh, Yong P. Kim, Masahiko Hayashi, Michiko Suzawa, Shiming Li, Chi-Tang Ho, Kanki Komiyama Inhibitory effect of a formulated extract from multiple citrus peels on LPS-induced inflammation in RAW 246.7 macrophages Functional Foods in Health and Disease 2013 3:242 DOI: 10.31989/ffhd.v3i6.50

15337 Phyu Phyu Khine Zar, Kozue Sakao, Fumio Hashimoto, Akiko Morishita, Makoto Fujii, Koji Wada, De-Xing Hou Antioxidant and anti-inflammatory activities of loquat (Eriobotrya japonica) tea Functional Foods in Health and Disease 2013 3:447 DOI: 10.31989/ffhd.v3i11.32

15773 Xi Yang, Yingnan Yang, Min Shi, Yuepeng Wang, Zhenya Zhang, Yifeng Lu Optimisation of Anthocyanin Extraction from Purple Pitaya and Verification of Antioxidant Properties, Antiproliferative Activity and Macrophage Proliferation Activity International Journal of Biology 2013 5 DOI: 10.5539/ijb.v5n3p19

16086 Kawabata K, Sugiyama Y, Sakano T, Ohigashi H. Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin Biofactors 2013 39(4):422-9 PubMed ID: 23554103 DOI: 10.1002/biof.1081

17188 Luquain-Costaz C, Lefai E, Arnal-Levron M, Markina D, Sakaï S, Euthine V, Makino A, Guichardant M, Yamashita S, Kobayashi T, Lagarde M, Moulin P, Delton-Vandenbroucke I. Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux Arterioscler Thromb Vasc Biol 2013 33(8):1803-11 PubMed ID: 23788762 DOI: 10.1161/ATVBAHA.113.301857

7589 Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, Todo S. A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. J Crohns Colitis 2012 6:215-25 PubMed ID: 22325176 DOI: 10.1016/j.crohns.2011.08.011

7599 Takano K, Sato K, Negishi Y, Aramaki Y. Involvement of actin cytoskeleton in macrophage apoptosis induced by cationic liposomes. Arch. Biochem. Biophys. 2012 518:89-94 PubMed ID: 22203089 DOI: 10.1016/j.abb.2011.12.009

7605 Odkhuu E, Koide N, Haque A, Tsolmongyn B, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T. Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ). Immunol. Lett. 2012 142:34-40 PubMed ID: 22193059 DOI: 10.1016/j.imlet.2011.12.001

7608 Takahashi K, Sugiyama T, Tokoro S, Neri P, Mori H. Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction. Cell. Immunol. 2012 273:73-8 PubMed ID: 22177846 DOI: 10.1016/j.cellimm.2011.11.004

7609 Uto T, Morinaga O, Tanaka H, Shoyama Y. Analysis of the synergistic effect of glycyrrhizin and other constituents in licorice extract on lipopolysaccharide-induced nitric oxide production using knock-out extract. Biochem. Biophys. Res. Commun. 2012 417:473-8 PubMed ID: 22178686 DOI: 10.1016/j.bbrc.2011.11.143

7621 Nakagawa S, Arai Y, Kishida T, Hiraoka N, Tsuchida S, Inoue H, Sakai R, Mazda O, Kubo T. Lansoprazole inhibits nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells. Inflammation 2012 35:1062-8 PubMed ID: 22134422 DOI: 10.1007/s10753-011-9412-7

7639 Uto T, Qin GW, Morinaga O, Shoyama Y. 17-Hydroxy-jolkinolide B, a diterpenoid from Euphorbia fischeriana, inhibits inflammatory mediators but activates heme oxygenase-1 expression in lipopolysaccharide-stimulated murine macrophages. Int. Immunopharmacol. 2012 12:101-9 PubMed ID: 22080918 DOI: 10.1016/j.intimp.2011.10.020

7667 Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H. Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice. J Physiol Sci 2012 62:59-62 PubMed ID: 21968540 DOI: 10.1007/s12576-011-0177-4

7678 Sugiyama T, Takahashi K, Tokoro S, Gotou T, Neri P, Mori H. Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression. Innate Immun 2012 18:429-37 PubMed ID: 21948282 DOI: 10.1177/1753425911416022

18461 Itoh T, Ando M, Tsukamasa Y, Wakimoto T, Nukaya H. Whiskey congeners suppress LPS/IFNγ-induced NO production in murine macrophage RAW 264 cells by inducing heme oxygenase-1 expression J Agric Food Chem 2012 60(51):12491-500 PubMed ID: 23199195 DOI: 10.1021/jf3040385

4881 Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol 2012 91(6):967-76 PubMed ID: 22422925 DOI: 10.1189/jlb.0112038

5417 Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung UI, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med 2012 10:80 PubMed ID: 22546323 DOI: 10.1186/1479-5876-10-80

6552 Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y, Hinoi E, Yoneda Y. Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts. J Cell Physiol 2012 227(10):3477-87 PubMed ID: 22252936 DOI: 10.1002/jcp.24048

9092 Hiroyasu Tsutsuki, Kinnosuke Yahiro, Kotaro Suzuki, Akira Suto, Kohei Ogura, Sayaka Nagasawa, Hideshi Ihara, Takeshi Shimizu, Hiroshi Nakajima, Joel Moss, Masatoshi Noda Subtilase Cytotoxin Enhances Escherichia Coli Survival in Macrophages by Suppression of Nitric Oxide Production Through the Inhibition of NF-κB Activation Infect Immun 2012 80 (11), 3939-51 PubMed ID: 22949549 DOI: 10.1128/IAI.00581-12

9246 Yoshikazu Morita, Aiko Ono-Ohmachi, Satoshi Higurashi, Hiroaki Matsuyama, Atsushi Serizawa, Tatsuo Takeya The bone-strengthening activity of milk basic protein is not dependent on lactoferrin International Dairy Journal 2012 27:40-46 DOI: 10.1016/j.idairyj.2012.07.003

10965 Makoto Ayaori, Emi Yakushiji, Masatsune Ogura, Kazuhiro Nakaya, Tetsuya Hisada, Harumi Uto-Kondo, Shunichi Takiguchi, Yoshio Terao, Makoto Sasaki, Tomohiro Komatsu, Maki Iizuka, Makiko Yogo, Yoshinari Uehara, Hiroyuki Kagechika, Tsuyoshi Nakanishi, Katsunori Ikewaki Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages Biochim Biophys Acta 2012 1821(4):561-72 PubMed ID: 22353356 DOI: 10.1016/j.bbalip.2012.02.004

15342 Toshiya KAWASAKI, Seiji GODA, Naoyuki MATSUMOTO Effect of Akt on the Differentiation into Osteoclasts Caused by RANKL Stimulation Journal of Oral Tissue Engineering 2012 10:67-76 DOI: 10.11223/jarde.10.67

15343 Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K. Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages J Nutr Sci Vitaminol (Tokyo) 2012 58(2):96-104 PubMed ID: 22790567 DOI: 10.3177/jnsv.58.96

15344 Kakutani R, Adachi Y, Takata H, Kuriki T, Ohno N. Essential role of Toll-like receptor 2 in macrophage activation by glycogen Glycobiology 2012 22(1):146-59 PubMed ID: 21873606 DOI: 10.1093/glycob/cwr122

15345 Miyashita K, Oyama T, Sakuta T, Tokuda M, Torii M. Anandamide induces matrix metalloproteinase-2 production through cannabinoid-1 receptor and transient receptor potential vanilloid-1 in human dental pulp cells in culture J Endod 2012 38(6):786-90 PubMed ID: 22595113 DOI: 10.1016/j.joen.2012.02.025

15346 Choi SH, Ahn JB, Kozukue N, Kim HJ, Nishitani Y, Zhang L, Mizuno M, Levin CE, Friedman M. Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells J Agric Food Chem 2012 60(15):3891-9 PubMed ID: 22482398 DOI: 10.1021/jf3003027

7558 Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages FEBS Lett 2012 586(10):1540-6 PubMed ID: 22673523 DOI: 10.1016/j.febslet.2012.04.018

7633 Yamamoto H, Abe Y, Miyazato A, Tanno D, Tanaka M, Miyasaka T, Ishii K, Kawakami K. Cryptococcus neoformans suppresses the activation of bone marrow-derived dendritic cells stimulated with its own DNA, but not with DNA from other fungi. FEMS Immunol. Med. Microbiol. 2011 63:363-72 PubMed ID: 22092563 DOI: 10.1111/j.1574-695X.2011.00859.x

7702 Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M, Hou DX. A genome-wide microarray highlights the antiinflammatory genes targeted by oolong tea theasinensin A in macrophages. Nutr Cancer 2011 63:1064-73 PubMed ID: 21864060 DOI: 10.1080/01635581.2011.596643

7704 Ozasa H, Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Uehara Y, Ogura M, Sasaki M, Komatsu T, Horii S, Mochizuki S, Yoshimura M, Ikewaki K. Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: findings from in vitro and ex vivo studies. Atherosclerosis 2011 219:141-50 PubMed ID: 21862012 DOI: 10.1016/j.atherosclerosis.2011.07.113

7725 Sakamoto T, Yamaguchi Y, Goto T, Takahashi N, Kawada T. An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages. Biosci. Biotechnol. Biochem. 2011 75:1582-7 PubMed ID: 21821941 DOI: 10.1271/bbb.110278

7745 Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M. Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem. Biophys. Res. Commun. 2011 411:143-9 PubMed ID: 21723254 DOI: 10.1016/j.bbrc.2011.06.116

7750 Fujimoto A, Akifusa S, Hirofuji T, Yamashita Y. Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell. Mol. Immunol. 2011 48:2052-8 PubMed ID: 21764457 DOI: 10.1016/j.molimm.2011.06.440

7789 Abiko Y, Miura T, Phuc BH, Shinkai Y, Kumagai Y. Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole. Toxicol. Appl. Pharmacol. 2011 255:32-9 PubMed ID: 21651925 DOI: 10.1016/j.taap.2011.05.013

7794 Haque A, Noman AS, Koide N, Odkhuu E, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T. An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Cancer Immunol. Immunother. 2011 60:1439-46 PubMed ID: 21644032 DOI: 10.1007/s00262-011-1048-9

7850 Egusa H, Doi M, Saeki M, Fukuyasu S, Akashi Y, Yokota Y, Yatani H, Kamisaki Y. The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells. Bone 2011 49:264-74 PubMed ID: 21504804 DOI: 10.1016/j.bone.2011.04.003

7851 Akagi T, Shima F, Akashi M. Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles. Biomaterials 2011 32:4959-67 PubMed ID: 21482432 DOI: 10.1016/j.biomaterials.2011.03.049

7901 Yamazaki Y, Kawano Y. Inhibitory effects of herbal alkaloids on the tumor necrosis factor-α and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages. Chem. Pharm. Bull. 2011 59:388-91 PubMed ID: 21372424 DOI: 10.1248/cpb.59.388

7921 Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Exp. Cell Res. 2011 317:1134-46 PubMed ID: 21338601 DOI: 10.1016/j.yexcr.2011.02.008

7949 Arisaka M, Takano K, Negishi Y, Arima H, Aramaki Y. Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes. Arch. Biochem. Biophys. 2011 508:72-7 PubMed ID: 21315683 DOI: 10.1016/j.abb.2011.02.003

7966 Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 2011 60:819-26 PubMed ID: 21282371 DOI: 10.2337/db10-0864

8010 Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol. Immunol. 2011 55:160-7 PubMed ID: 21204955 DOI: 10.1111/j.1348-0421.2010.00304.x

8052 Miyazaki T, Miyauchi S, Anada T, Imaizumi H, Suzuki O. Evaluation of osteoclastic resorption activity using calcium phosphate coating combined with labeled polyanion. Anal. Biochem. 2011 410:7-12 PubMed ID: 21078287 DOI: 10.1016/j.ab.2010.11.014

8058 Oshima H, Hioki K, Popivanova BK, Oguma K, Van Rooijen N, Ishikawa TO, Oshima M. Prostaglandin E? signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology 2011 140:596-607.e7 PubMed ID: 21070778 DOI: 10.1053/j.gastro.2010.11.007

8066 Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT. Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo. Eur. J. Pharmacol. 2011 650:511-8 PubMed ID: 21047508 DOI: 10.1016/j.ejphar.2010.10.048

8067 Kamio N, Akifusa S, Yamashita Y. Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species. Free Radic. Res. 2011 45:336-41 PubMed ID: 21034360 DOI: 10.3109/10715762.2010.532495

8135 Fukata N, Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukui T, Matsushita M, Nishio A, Tabata Y, Okazaki K. The effective therapy of cyclosporine A with drug delivery system in experimental colitis. J Drug Target 2011 19:458-67 PubMed ID: 20804404 DOI: 10.3109/1061186X.2010.511224

8415 Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun 2011 17:97-105 PubMed ID: 20023007 DOI: 10.1177/1753425909353641

8455 Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada H, Sugawara S, Endo Y. Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). Innate Immun 2011 17:3-15 PubMed ID: 19897531 DOI: 10.1177/1753425909347508

15296 Oka H, Mori M, Kihara H. F-spondin inhibits migration and differentiation of osteoclastic precursors J Periodontol 2011 82(12):1776-83 PubMed ID: 21488757 DOI: 10.1902/jop.2011.110111

15348 Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa TO, Oshima M. Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis Cancer Sci 2011 102(4):713-9 PubMed ID: 21205091 DOI: 10.1111/j.1349-7006.2011.01847.x

15349 Sugiyama K, Kawakami H, Kamata Y, Sugita-Konishi Y. Effect of a combination of deoxynivalenol and nivalenol on lipopolisaccharide-induced nitric oxide production by mouse macrophages Mycotoxin Res 2011 27(1):57-62 PubMed ID: 23605623 DOI: 10.1007/s12550-010-0076-1

15350 Kizaki T, Maegawa T, Sakurai T, Ogasawara JE, Ookawara T, Oh-ishi S, Izawa T, Haga S, Ohno H. Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages Biochem Biophys Res Commun 2011 413(3):454-9 PubMed ID: 21907183 DOI: 10.1016/j.bbrc.2011.08.117

15351 Terao Y, Ayaori M, Ogura M, Yakushiji E, Uto-Kondo H, Hisada T, Ozasa H, Takiguchi S, Nakaya K, Sasaki M, Komatsu T, Iizuka M, Horii S, Mochizuki S, Yoshimura M, Ikewaki K. Effect of sulfonylurea agents on reverse cholesterol transport in vitro and vivo J Atheroscler Thromb 2011 18(6):513-30 PubMed ID: 21636950 DOI: 10.5551/jat.7641

15352 Eisuke DOMAE, Yumiko OGAWA, Osamu TAKEUCHI, Yosuke UJII, Yu KATO, Toshiya KAWASAKI, Hiroshi HAYASHI, Reiko KOMASA, Naochika DOMAE, Seiji GODA, Takashi IKEO The Effect of Lysenin on the Differentiation into Osteoclast Cells Journal of Oral Tissue Engineering 2011 9:3-9 DOI: 10.11223/jarde.9.3

15353 Ishijima Y, Kawamura T, Kimura A, Kohno A, Okada T, Tsuji T, Watanabe Y. Toll-like receptor 4-dependent adjuvant activity of Kakkon-to extract exists in the high molecular weight polysaccharide fraction Int J Immunopathol Pharmacol 2011 24(1):43-54 PubMed ID: 21496386 DOI: 10.1177/039463201102400106

15354 Mukai S, Kitazawa R, Ishii J, Kondo T, Hakozaki A, Horiuchi K, Haraguch R, Mori K, Kitazawa S. Identification and analysis of function of a novel splicing variant of mouse receptor activator of NF-κB Mol Cell Biochem 2011 350(1-2):29-38 PubMed ID: 21153864 DOI: 10.1007/s11010-010-0679-z

15355 Takayuki Anno, Keiichi Motoyama, Taishi Higashi, Fumitoshi Hirayama, Kaneto Uekama, Hidetoshi Arima Preparation and evaluation of polyamidoamine dendrimer (G2)/branched-β-cyclodextrin conjugate as a novel gene transfer carrier Journal of Inclusion Phenomena and Macrocyclic Chemistry 2011 70:339-344 DOI: 10.1007/s10847-010-9868-3

15356 Cui H, Okuhira K, Ohoka N, Naito M, Kagechika H, Hirose A, Nishimaki-Mogami T. Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR Biochem Pharmacol 2011 81(6):819-24 PubMed ID: 21219878 DOI: 10.1016/j.bcp.2010.12.023

15357 Di Guan, Zhenya Zhang, Yingnan Yang, Guoqing Xing, Jiqiang Liu Immunomodulatory Activity of Polysaccharide from the Roots of Actinidia kolomikta on Macrophages International Journal of Biology 2011 3 DOI: 10.5539/ijb.v3n2p3

15359 Aoyagi Y, Adachi Y, Ozawa K, Yokomizo C, Gui MY, Jin YR, Li XW, Ohno N, Takeya K. Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation Bioorg Med Chem 2011 19(7):2450-7 PubMed ID: 21393004 DOI: 10.1016/j.bmc.2011.02.002

8050 Hou DX, Masuzaki S, Tanigawa S, Hashimoto F, Chen J, Sogo T, Fujii M. Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: structure-activity relationship and molecular mechanisms. J. Agric. Food Chem. 2010 58:12735-43 PubMed ID: 21082860 DOI: 10.1021/jf103605j

8060 Ueda H, Ippoushi K, Takeuchi A. Repeated oral administration of a squeezed ginger (Zingiber officinale) extract augmented the serum corticosterone level and had anti-inflammatory properties. Biosci. Biotechnol. Biochem. 2010 74:2248-52 PubMed ID: 21071834 DOI: 10.1271/bbb.100456

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

8102 Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells. Biol. Pharm. Bull. 2010 33:1733-9 PubMed ID: 20930384 DOI: 10.1248/bpb.33.1733

8113 Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol. Cancer Ther. 2010 9:2960-9 PubMed ID: 20858724 DOI: 10.1158/1535-7163.MCT-10-0489

8136 Shikama Y, Nagai Y, Okada S, Oizumi T, Shimauchi H, Sugawara S, Endo Y. Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate. Toxicol. Lett. 2010 199:123-8 PubMed ID: 20804833 DOI: 10.1016/j.toxlet.2010.08.013

8148 Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K. Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo. Atherosclerosis 2010 213:135-41 PubMed ID: 20723893 DOI: 10.1016/j.atherosclerosis.2010.07.024

8160 Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. J. Nat. Prod. 2010 73:1332-6 PubMed ID: 20695472 DOI: 10.1021/np100120c

8168 Yoshikawa K, Kokudo N, Hashimoto T, Yamamoto K, Inose T, Kimura T. Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity. Biol. Pharm. Bull. 2010 33:1355-9 PubMed ID: 20686231 DOI: 10.1248/bpb.33.1355

8181 Nakatsuka R, Nozaki T, Shinohara M, Ohura K. Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells. J. Pharmacol. Sci. 2010 113:271-5 PubMed ID: 20647687 DOI: 10.1254/jphs.09286sc

8208 Yano H, Uchida M, Nakai R, Ishida K, Kato Y, Kawanishi N, Shiva D. Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice. Eur. J. Appl. Physiol. 2010 110:797-803 PubMed ID: 20602110 DOI: 10.1007/s00421-010-1560-1

8210 Shadat NM, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53. Cancer Invest. 2010 28:806-12 PubMed ID: 20594067 DOI: 10.3109/07357907.2010.494323

8214 Sakai H, Moriura Y, Notomi T, Kawawaki J, Ohnishi K, Kuno M. Phospholipase C-dependent Ca2+-sensing pathways leading to endocytosis and inhibition of the plasma membrane vacuolar H+-ATPase in osteoclasts. Am. J. Physiol., Cell Physiol. 2010 299:C570-8 PubMed ID: 20592242 DOI: 10.1152/ajpcell.00486.2009

8224 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nonaka K, Yamashita Y. Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells. J. Cell. Biochem. 2010 111:597-606 PubMed ID: 20564237 DOI: 10.1002/jcb.22745

8228 Kato Y, Koide N, Komatsu T, Tumurkhuu G, Dagvadorj J, Kato K, Yokochi T. Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway. Horm. Metab. Res. 2010 42:632-6 PubMed ID: 20560107 DOI: 10.1055/s-0030-1255033

8229 Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation. Cell. Immunol. 2010 264:114-8 PubMed ID: 20557878 DOI: 10.1016/j.cellimm.2010.05.007

8249 Ohata S, Moriyama C, Yamashita A, Nishida T, Kusumoto C, Mochida S, Minami Y, Nakada J, Shomori K, Inagaki Y, Ohta Y, Matsura T. Polaprezinc Protects Mice against Endotoxin Shock. J Clin Biochem Nutr 2010 46:234-43 PubMed ID: 20490319 DOI: 10.3164/jcbn.09-125

8258 Yamaguchi N, Hamachi T, Kamio N, Akifusa S, Masuda K, Nakamura Y, Nonaka K, Maeda K, Hanazawa S, Yamashita Y. Expression levels of adiponectin receptors and periodontitis. J. Periodont. Res. 2010 45:296-300 PubMed ID: 20470261 DOI: 10.1111/j.1600-0765.2009.01222.x

8273 Xiao G, Miyazato A, Abe Y, Zhang T, Nakamura K, Inden K, Tanaka M, Tanno D, Miyasaka T, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Yamamoto N, Kunishima H, Hirakata Y, Kaku M, Kawakami K. Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell. Immunol. 2010 263:241-50 PubMed ID: 20451901 DOI: 10.1016/j.cellimm.2010.04.006

8282 Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression. Immunol. Lett. 2010 131:166-9 PubMed ID: 20417662 DOI: 10.1016/j.imlet.2010.04.006

8286 Khuda II, Koide N, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. Immunology 2010 131:59-66 PubMed ID: 20406300 DOI: 10.1111/j.1365-2567.2010.03274.x

8335 Kitagawa Y, Tohya Y, Ike F, Kajita A, Park SJ, Ishii Y, Kyuwa S, Yoshikawa Y. Indirect ELISA and indirect immunofluorescent antibody assay for detecting the antibody against murine norovirus S7 in mice. Exp. Anim. 2010 59:47-55 PubMed ID: 20224169 DOI: 10.1538/expanim.59.47

8368 Shimoda H, Shan SJ, Tanaka J, Seki A, Seo JW, Kasajima N, Tamura S, Ke Y, Murakami N. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J Med Food 2010 13:156-62 PubMed ID: 20136450 DOI: 10.1089/jmf.2009.1084

8369 Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int. Immunol. 2010 22:271-80 PubMed ID: 20133493 DOI: 10.1093/intimm/dxq005

8372 Arisaka M, Nakamura T, Yamada A, Negishi Y, Aramaki Y. Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. FEBS Lett. 2010 584:1016-20 PubMed ID: 20122929 DOI: 10.1016/j.febslet.2010.01.055

8373 Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, Uchikawa S, Takaishi H, Matsumoto M, Chiba K, Horiuchi K, Toyama Y. Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages. J. Immunol. 2010 184:2442-8 PubMed ID: 20118276 DOI: 10.4049/jimmunol.0901188

8396 Suzuki T, Chang MO, Kitajima M, Takaku H. Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses. Cell. Immunol. 2010 262:35-43 PubMed ID: 20060108 DOI: 10.1016/j.cellimm.2009.12.005

8426 Hirai S, Uemura T, Mizoguchi N, Lee JY, Taketani K, Nakano Y, Hoshino S, Tsuge N, Narukami T, Yu R, Takahashi N, Kawada T. Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Mol Nutr Food Res 2010 54:797-804 PubMed ID: 19998383 DOI: 10.1002/mnfr.200900208

8456 Fujimoto A, Akifusa S, Kamio N, Hirofuji T, Nonaka K, Yamashita Y. Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species. Free Radic. Res. 2010 44:128-34 PubMed ID: 19886750 DOI: 10.3109/10715760903348328

8462 Matsubara T, Ikeda F, Hata K, Nakanishi M, Okada M, Yasuda H, Nishimura R, Yoneda T. Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts. J. Bone Miner. Res. 2010 25:1068-76 PubMed ID: 19874196 DOI: 10.1359/jbmr.091039

8465 Sugiyama K, Muroi M, Tanamoto K, Nishijima M, Sugita-Konishi Y. Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. Toxicol. Lett. 2010 192:150-4 PubMed ID: 19857559 DOI: 10.1016/j.toxlet.2009.10.020

8488 Kishimoto Y, Tani M, Uto-Kondo H, Iizuka M, Saita E, Sone H, Kurata H, Kondo K. Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. Eur J Nutr 2010 49:119-26 PubMed ID: 19784539 DOI: 10.1007/s00394-009-0056-4

5872 Chen J, Uto T, Tanigawa S, Yamada-Kato T, Fujii M, Hou DX. Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl)hexyl isothiocyanate in macrophages. Exp Ther Med 2010 1(1):33-40 PubMed ID: 23136589 DOI: 10.3892/etm_00000006

8207 Kaori Yoshino, Kaoru Saijo, Chikako Noro and Yukio Nakamura Development of a simple method to determine the mouse strain from which cultured cell lines originated Interdisciplinary Bio Central 2010 2:0014 DOI: 10.4051/ibc.2010.2.4.0014

8268 Miyazaki T, Miyauchi S, Tawada A, Anada T, Suzuki O. Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells. Dent Mater J 2010 29(4):403-10 PubMed ID: 20610874 DOI: 10.4012/dmj.2009-132

15360 Ii H, Imai T, Yaegaki K, Irie K, Ekuni D, Morita M. Oral malodorous compound induces osteoclast differentiation without receptor activator of nuclear factor κB ligand J Periodontol 2010 81(11):1691-7 PubMed ID: 20583917 DOI: 10.1902/jop.2010.100116

15361 Uto T, Suangkaew N, Morinaga O, Kariyazono H, Oiso S, Shoyama Y. Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-kappaB and MAPK activation in murine macrophages Am J Chin Med 2010 38(5):985-94 PubMed ID: 20821828 DOI: 10.1142/S0192415X10008408

15362 Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis J Hepatol 2010 53(2):318-25 PubMed ID: 20570384 DOI: 10.1016/j.jhep.2010.03.008

15363 B. Sritularak, A. Tantituvanont1, P. Chanvorachote1, K. Meksawan1, T. Miyamoto2, Y. Kohno and K. Likhitwitayawuid Flavonoids with free radical scavenging activity and nitric oxide inhibitory effect from the stem bark of Artocarpus gomezianus Journal of Medicinal Plants Research 2010 4:387-392 DOI: 10.5897/JMPR09.433

15364 Takeichi SAKATA, Seiji GODA, Yumiko OGAWA, Takashi IKEO, Shosuke MORITA β1-Integrin-Dependent Macrophage Migration is Regulated by MAP Kinase Journal of Oral Tissue Engineering 2010 8:124-132 DOI: 10.11223/jarde.8.124

18302 Bouvier J, Zemski Berry KA, Hullin-Matsuda F, Makino A, Michaud S, Geloën A, Murphy RC, Kobayashi T, Lagarde M, Delton-Vandenbroucke I. Selective decrease of bis(monoacylglycero)phosphate content in macrophages by high supplementation with docosahexaenoic acid J Lipid Res 2009 50(2):243-55 PubMed ID: 18809971 DOI: 10.1194/jlr.M800300-JLR200

8359 Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology 2009 61:125-34 PubMed ID: 20162352 DOI: 10.1007/s10616-010-9253-5

8495 Katsuura S, Imamura T, Bando N, Yamanishi R. beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages. Mol Nutr Food Res 2009 53:1396-405 PubMed ID: 19760679 DOI: 10.1002/mnfr.200800566

8549 Shioiri T, Muroi M, Hatao F, Nishida M, Ogawa T, Mimura Y, Seto Y, Kaminishi M, Tanamoto K. Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide. Biochim. Biophys. Acta 2009 1792:1011-8 PubMed ID: 19559790 DOI: 10.1016/j.bbadis.2009.06.006

8550 Kamio N, Akifusa S, Yamaguchi N, Nonaka K, Yamashita Y. Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomycetemcomitans. FEMS Immunol. Med. Microbiol. 2009 56:241-7 PubMed ID: 19552715 DOI: 10.1111/j.1574-695X.2009.00573.x

8551 Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice. FEMS Immunol. Med. Microbiol. 2009 56:204-11 PubMed ID: 19538513 DOI: 10.1111/j.1574-695X.2009.00567.x

8578 Miyazato A, Nakamura K, Yamamoto N, Mora-Montes HM, Tanaka M, Abe Y, Tanno D, Inden K, Gang X, Ishii K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Mitsutake K, Gow NA, Kaku M, Kawakami K. Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans. Infect. Immun. 2009 77:3056-64 PubMed ID: 19433551 DOI: 10.1128/IAI.00840-08

8589 Seddek Al, Mahmoud ME, Shiina T, Hirayama H, Iwami M, Miyazawa S, Nikami H, Takewaki T, Shimizu Y. Extract from Calotropis procera latex activates murine macrophages. J Nat Med 2009 63:297-303 PubMed ID: 19399577 DOI: 10.1007/s11418-009-0335-7

8637 Tomimori Y, Mori K, Koide M, Nakamichi Y, Ninomiya T, Udagawa N, Yasuda H. Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss. J. Bone Miner. Res. 2009 24:1194-205 PubMed ID: 19257825 DOI: 10.1359/jbmr.090217

8640 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nishihara T, Yamashita Y. Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2. Free Radic. Biol. Med. 2009 46:1308-16 PubMed ID: 19250964 DOI: 10.1016/j.freeradbiomed.2009.02.014

8641 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Yamashita Y. Involvement of Ca(2+) in globular adiponectin-induced reactive oxygen species. Biochem. Biophys. Res. Commun. 2009 381:649-53 PubMed ID: 19249286 DOI: 10.1016/j.bbrc.2009.02.115

8642 Hassan F, Islam S, Tumurkhuu G, Dagvadorj J, Naiki Y, Komatsu T, Koide N, Yoshida T, Yokochi T. Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells. Cell. Immunol. 2009 256:99-103 PubMed ID: 19251253 DOI: 10.1016/j.cellimm.2009.01.013

8648 Kasugai C, Morikawa A, Naiki Y, Koide N, Komatsu T, Yoshida T, Yokochi T. Concanavalin A induces formation of osteoclast-like cells in RAW 264.7 mouse macrophage cells. Immunopharmacol Immunotoxicol 2009 31:103-7 PubMed ID: 19234958 DOI: 10.1080/08923970802438417

8654 Iftakhar-E-Khuda I, Koide N, Hassan F, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Novel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells. Clin. Exp. Immunol. 2009 155:552-8 PubMed ID: 19220841 DOI: 10.1111/j.1365-2249.2008.03779.x

8663 Noman AS, Koide N, Hassan F, I-E-Khuda I, Dagvadorj J, Tumurkhuu G, Islam S, Naiki Y, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression. Innate Immun 2009 15:33-41 PubMed ID: 19201823 DOI: 10.1177/1753425908099317

8691 Inden K, Kaneko J, Miyazato A, Yamamoto N, Mouri S, Shibuya Y, Nakamura K, Aoyagi T, Hatta M, Kunishima H, Hirakata Y, Itoh Y, Kaku M, Kawakami K. Toll-like receptor 4-dependent activation of myeloid dendritic cells by leukocidin of Staphylococcus aureus. Microbes Infect. 2009 11:245-53 PubMed ID: 19111627 DOI: 10.1016/j.micinf.2008.11.013

8739 Nakamura T, Kodama N, Arai Y, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ishikawa T, Ueno K, Yano S. Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7. J Nat Med 2009 63:21-7 PubMed ID: 18636311 DOI: 10.1007/s11418-008-0277-5

8740 Nakamura T, Kodama N, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ueno K, Ishikawa T, Yano S. Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7. J Nat Med 2009 63:107-10 PubMed ID: 18626726 DOI: 10.1007/s11418-008-0276-6

8742 Nakamura T, Kodama N, Oda M, Tsuchiya S, Arai Y, Kumamoto T, Ishikawa T, Ueno K, Yano S. The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells. J Nat Med 2009 63:15-20 PubMed ID: 18607531 DOI: 10.1007/s11418-008-0268-6

10145 Murakami M, Kawachi H, Ogawa K, Nishino Y, Funaba M. Receptor expression modulates the specificity of transforming growth factor-beta signaling pathways. Genes Cells 2009 14(4):469-82 PubMed ID: 19335617 DOI: 10.1111/j.1365-2443.2009.01283.x

8170 Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, Kato S, Terao J, Inakuma T, Takeda E. Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J Bone Miner Metab 2009 27(6):673-81 PubMed ID: 19495926 DOI: 10.1007/s00774-009-0088-0

11020 Masayuki TAIRA et al DNA Microarray Analyses of the Effects of LPS-stimulation and IC50 Nickel Ions on Gene Expressions of Mouse Macrophage-like Cell Line RAW264 Nano Biomedicine 2009 1:59-69 DOI: 10.11344/nano.1.59

12295 Ken Shirato, Takako Kizaki, Takuya Sakurai, Jun-Etsu Ogasawara, Yoshinaga Ishibashi, Takehiko Iijima, Chikako Okada, Izumi Noguchi, Kazuhiko Imaizumi, Naoyuki Taniguchi, Hideki Ohno Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1 Pflugers Arch 2009 459(1):93-103 PubMed ID: 19641936 DOI: 10.1007/s00424-009-0702-y

15368 Namba T, Tanaka K, Ito Y, Ishihara T, Hoshino T, Gotoh T, Endo M, Sato K, Mizushima T. Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis Am J Pathol 2009 174(5):1786-98 PubMed ID: 19359519 DOI: 10.2353/ajpath.2009.080864

15369 Iigo M, Alexander DB, Long N, Xu J, Fukamachi K, Futakuchi M, Takase M, Tsuda H. Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine Biochimie 2009 91(1):86-101 PubMed ID: 18634843 DOI: 10.1016/j.biochi.2008.06.012

15370 Aoyama T, Takeshita K, Kikuchi R, Yamamoto K, Cheng XW, Liao JK, Murohara T. gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice Biochem Biophys Res Commun 2009 383(2):216-21 PubMed ID: 19345673 DOI: 10.1016/j.bbrc.2009.03.154

16614 Kajiura T, Takeda T, Sakata S, Sakamoto M, Hashimoto M, Suzuki H, Suzuki M, Benno Y. Change of intestinal microbiota with elemental diet and its impact on therapeutic effects in a murine model of chronic colitis Dig Dis Sci 2009 54(9):1892-900 PubMed ID: 19058004 DOI: 10.1007/s10620-008-0574-6

18331 Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation Biochem Biophys Res Commun 2008 369(2):333-8 PubMed ID: 18267111 DOI: 10.1016/j.bbrc.2008.02.002

18376 Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Yoshida T, Yokochi T. Receptor activator of nuclear factor-kappa B ligand induces osteoclast formation in RAW 264.7 macrophage cells via augmented production of macrophage-colony-stimulating factor Microbiol Immunol 2008 52(12):585-90 PubMed ID: 19120972 DOI: 10.1111/j.1348-0421.2008.00076.x

8731 Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Yamashita Y. Regulation of globular adiponectin-induced apoptosis by reactive oxygen/nitrogen species in RAW264 macrophages. Free Radic. Biol. Med. 2008 45:1326-39 PubMed ID: 18775488 DOI: 10.1016/j.freeradbiomed.2008.08.005

8754 Yoshida H, Kwon AH, Habara K, Yamada M, Kaibori M, Kamiyama Y, Nishizawa M, Ito S, Okumura T. Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages. Shock 2008 30:734-9 PubMed ID: 18496239 DOI: 10.1097/SHK.0b013e318173ea0b

5375 Nishida K, Kuchiiwa S, Oiso S, Futagawa T, Masuda S, Takeda Y, Yamada K. Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. Cancer Sci 2008 99(8):1618-25 PubMed ID: 18754875 DOI: 10.1111/j.1349-7006.2008.00877.x

3578 Ando M, Tu W, Nishijima K, Iijima S. Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs. Biochem Biophys Res Commun 2008 369(3):878-83 PubMed ID: 18325328 DOI: 10.1016/j.bbrc.2008.02.111

6521 Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 2008 283(36):24682-9 PubMed ID: 18617520 DOI: 10.1074/jbc.M709857200

6804 Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivatio Biochem Biophys Res Commun 2008 374(4):683-7 PubMed ID: 18662673 DOI: 10.1016/j.bbrc.2008.07.090

13756 Murakami M, Kondo S, Funaba M. Expression and function of alternative splice variants of the mouse TGF-beta type I receptor Cell Biol Int 2008 32(7):848-54 PubMed ID: 18474439 DOI: 10.1016/j.cellbi.2008.03.020

13958 Kawanishi N, Tanaka Y, Kato Y, Shiva D, Yano H. Lipopolysaccharide-induced monocyte chemotactic protein-1 is enhanced by suppression of nitric oxide production, which depends on poor CD14 expression on the surface of skeletal muscle Cell Biochem Funct 2008 26(4):486-9 PubMed ID: 18383566 DOI: 10.1002/cbf.1471

15371 Suzuki N, Yoshimura Y, Deyama Y, Suzuki K, Kitagawa Y. Mechanical stress directly suppresses osteoclast differentiation in RAW264.7 cells Int J Mol Med 2008 21(3):291-6 PubMed ID: 18288375

15372 Ishii J, Kitazawa R, Mori K, McHugh KP, Morii E, Kondo T, Kitazawa S. Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF J Cell Biochem 2008 105(3):896-904 PubMed ID: 18759249 DOI: 10.1002/jcb.21886

15373 Yumiko Ogawa, Seiji Goda, Shosuke Morita The Effect of Methyl-β-cyclodextrin on the Differentiation of RAW264 Cells into Osteoclasts Oral Science International 2008 5:15-23 DOI: 10.1016/s1348-8643(08)80002-x

15375 Ken-ichiro Minato Immunomodulation Activity of a Polysaccharide Fraction of a Culinary-Medicinal Mushroom, Pleurotus citrinopileatus Singer (Agaricomycetideae), in Vitro International Journal of Medicinal Mushrooms 2008 10:235-244 DOI: 10.1615/intjmedmushr.v10.i3.40

15376 Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, Oshima M. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells EMBO J 2008 27(12):1671-81 PubMed ID: 18511911 DOI: 10.1038/emboj.2008.105

15377 Ryo Kakutani, Yoshiyuki Adachi, Hideki Kajiura, Hiroki Takata, Naohito Ohno, Takashi Kuriki Stimulation of macrophage by enzymatically synthesized glycogen: the relationship between structure and biological activity Biocatalysis and Biotransformation 2008 26:152-160 DOI: 10.1080/10242420701804541

16649 Yeh CM, Yeh CK, Hsu XY, Luo QM, Lin MY. Extracellular expression of a functional recombinant Ganoderma lucidium immunomodulatory protein by Bacillus subtilis and Lactococcus lactis Appl Environ Microbiol 2008 74(4):1039-49 PubMed ID: 18156317 DOI: 10.1128/AEM.01547-07

8850 Yamaguchi N, Kukita T, Li YJ, Martinez Argueta JG, Saito T, Hanazawa S, Yamashita Y. Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol. Med. Microbiol. 2007 49:28-34 PubMed ID: 17094790 DOI: 10.1111/j.1574-695X.2006.00164.x

18605 Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T. Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells Biochem Biophys Res Commun 2007 360(2):346-5 PubMed ID: 17597583 DOI: 10.1016/j.bbrc.2007.06.023

18607 Yanagishita T, Watanabe D, Akita Y, Nakano A, Ohshima Y, Tamada Y, Matsumoto Y. Construction of novel in vitro epithelioid cell granuloma model from mouse macrophage cell line Arch Dermatol Res 2007 299(8):399-403 PubMed ID: 17704931 DOI: 10.1007/s00403-007-0778-1

4889 Takayoshi Suganami, Kanami Tanimoto-Koyama, Junko Nishida, Michiko Itoh, Xunmei Yuan, Shinji Mizuarai, Hidehito Kotani, Shoji Yamaoka, Kensuke Miyake, Seiichiro Aoe, Yasutomi Kamei and Yoshihiro Ogawa Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid−Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages Arterioscler Thromb Vasc Biol 2007 27:84-91 PubMed ID: 17082484 DOI: 10.1161/01.ATV.0000251608.09329.9a

7269 Takarada T, Hinoi E, Kambe Y, Sahara K, Kurokawa S, Takahata Y, Yoneda Y. Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid. Eur J Pharmacol 2007 575(1-3):1-11 PubMed ID: 17698058 DOI: 10.1016/j.ejphar.2007.07.041

7349 Ito M, Haito S, Furumoto M, Uehata Y, Sakurai A, Segawa H, Tatsumi S, Kuwahata M, Miyamoto K. Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells. Am J Physiol Cell Physiol 2007 292(1):C526-34 PubMed ID: 16971494 DOI: 10.1152/ajpcell.00357.2006

7354 Takahashi N, Udagawa N, Kobayashi Y, Suda T. Generation of osteoclasts in vitro, and assay of osteoclast activity. Methods Mol Med 2007 135:285-301 PubMed ID: 17951666 DOI: 10.1007/978-1-59745-401-8_18

7387 Murakami Y, Hirata A, Ito S, Shoji M, Tanaka S, Yasui T, Machino M, Fujisawa S. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res 2007 27(2):801-7 PubMed ID: 17465205

10072 Yoshinari Uehara 1, Shin-ichiro Miura, Arnold von Eckardstein, Satomi Abe, Akihiro Fujii, Yoshino Matsuo, Stephan Rust, Stefan Lorkowski, Gerd Assmann, Tatsuo Yamada, Keijiro Saku Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element Atherosclerosis 2007 191(1):11-21 PubMed ID: 16730733 DOI: 10.1016/j.atherosclerosis.2006.04.018

12814 Uto T, Fujii M, Hou DX. Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate Oncol Rep 2007 17(1):233-8 PubMed ID: 17143503

15374 Natalie Ohashi, Miho Nakamura, Akiko Nagai, Yumi Tanaka, Yasutaka Sekijima, Kimihiro Yamashita Comparison of Hydroxyapatite with Carbonate Apatite in Osteoclastic Cell Resorptive Activity Key Engineering Materials 2007 361-363:1039-1042 DOI: 10.4028/www.scientific.net/kem.361-363.1039

15378 Yuki Kaneshita, Seiji Goda, Tatsuo Kawamoto The effect of matrix metalloproteinase-9 on the differentiation into osteoclast cells on RAW264 cells Orthodontic Waves 2007 66:122-128 DOI: 10.1016/j.odw.2007.09.003

15379 Kentaro Harutsugu, Kyoko Watanabe, Michiharu Daito The role of anti immune response on adenosine stimulated macrophages Pediatric Dental Journal 2007 1:40-46 DOI: 10.11411/pdj.17.40

15642 Junji TANAKA, Shao-Jie SHAN, Naoki KASAJIMA, Hiroshi SHIMODA Suppressive Effect of Defatted Kiwi Fruit Seed Extract on Acute Inflammation and Skin Pigmentation Food Science and Technology Research 2007 13:310-314 DOI: 10.3136/fstr.13.310

8815 Taira M, Sasaki K, Saitoh S, Nezu T, Sasaki M, Kimura S, Terasaki K, Sera K, Narushima T, Araki Y. Accumulation of element Ti in macrophage-like RAW264 cells cultured in medium with 1 ppm Ti and effects on cell viability, SOD production and TNF-alpha secretion. Dent Mater J 2006 25:726-32 PubMed ID: 17338307 DOI: 10.4012/dmj.25.726

8917 Soji Fukumoto, Paramasari Dirgahayu, Kozue Nunomura, Haruyo Matsuura andKazumitsu Hirai Suppression of LPS-induced Cyclooxygenase-2 (cox-2) Gene Expression in Mouse Macrophages by Excretory/Secretory Products of Spirometra erinaceieuropaei Plerocercoids Yonago Acta Med. 2006 49:39-47

6489 Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, Nakao A. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther 2006 8(5):R146 PubMed ID: 16945157 DOI: 10.1186/ar2038

6976 Nagai N, Anzawa T, Satoh Y, Suzuki T, Tajima K, Munekata M. Activities of MC3T3-E1 cells cultured on gamma-irradiated salmon atelocollagen scaffold. J Biosci Bioeng 2006 101(6):511-4 PubMed ID: 16935254 DOI: 10.1263/jbb.101.511

7020 Murakami Y, Shoji M, Ogiwara T, Tanaka S, Yokoe I, Fujisawa S. Preventive effect of ortho dimer of butylated hydroxyanisole on activator protein-1 activation and cyclooxygenase-2 expression in macrophages stimulated by fimbriae of Porphyromonas gingivalis, an oral anaerobe. Anticancer Res 2006 26(4B):2915-20 PubMed ID: 16886613

7039 Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H. Requirement of Smad3 for mast cell growth. Cell Immunol 2006 240(1):47-52 PubMed ID: 16839529 DOI: 10.1016/j.cellimm.2006.06.002

11012 Mohammad Samiul Alam, Mohammad Hasan Zaki, Jun Yoshitake, Teruo Akuta, Takayuki Ezaki, Takaaki Akaike Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection Microb Pathog 2006 40(3):116-25 PubMed ID: 16448800 DOI: 10.1016/j.micpath.2005.11.007

13660 Kimura Y, Sumiyoshi M, Suzuki T, Sakanaka M. Antitumor and antimetastatic activity of a novel water-soluble low molecular weight beta-1, 3-D-glucan (branch beta-1,6) isolated from Aureobasidium pullulans 1A1 strain black yeast Anticancer Res 2006 26(6B):4131-41 PubMed ID: 17201124

13729 Imamura T, Bando N, Yamanishi R. Beta-carotene modulates the immunological function of RAW264, a murine macrophage cell line, by enhancing the level of intracellular glutathione Biosci Biotechnol Biochem 2006 70(9):2112-20. PubMed ID: 16960387 DOI: 10.1271/bbb.60056

15381 KYOKO WATANABE, SHINYA SHIRASU, KIYOSHI DAITO, MASAHARU MOTOYAMA, YOSHITOMO OGAWA, KOJI NAKAI, KIYOSHI OHURA, MICHIHARU DAITO Differentiation of the expression of A2a adenosine receptor in macrophage cell lines RAW264 ORAL THERAPEUTICS AND PHARMACOLOGY 2006 25:8-16 DOI: 10.11263/jsotp1982.25.8

15382 Hida S, Nagi-Miura N, Adachi Y, Ohno N. Beta-glucan derived from zymosan acts as an adjuvant for collagen-induced arthritis Microbiol Immunol 2006 50(6):453-61 PubMed ID: 16785717 DOI: 10.1111/j.1348-0421.2006.tb03814.x

15383 Casolaro M, Bottari S, Ito Y. Vinyl polymers based on L-histidine residues. Part 2. Swelling and electric behavior of smart poly(ampholyte) hydrogels for biomedical applications Biomacromolecules 2006 ;7(5):1439-48 PubMed ID: 16677025 DOI: 10.1021/bm0509671

15384 Funaba M, Murakami M, Ikeda T, Ogawa K, Tsuchida K, Sugino H. Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells Biochim Biophys Acta 2006 1763(8):900-6 PubMed ID: 16872693 DOI: 10.1016/j.bbamcr.2006.06.002

3160 Wei, Ping, Taniguchi, Susumu, Sakai, Yoshiyuki, Imamura, Minako, Inoguchi, Toyoshi, Nawata, Hajime, Oda, Shinya, Nakabeppu, Yusaku, Nishimura, Junji, Ikuyama, Shoichiro Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages. J Biochem 2005 138:399-412 PubMed ID: 16272134 DOI: 10.1093/jb/mvi136

2903 Shimomura-Shimizu M, Sugiyama K, Muroi M, Tanamoto K Alachlor and carbaryl suppress lipopolysaccharide-induced iNOS expression by differentially inhibiting NF-kappaB activation. Biochem Biophys Res Commun 2005 332:793-9 PubMed ID: 15907790 DOI: 10.1016/j.bbrc.2005.05.024

2922 Musikacharoen, Tipayaratn, Oguma, Asako, Yoshikai, Yasunobu, Chiba, Norika, Masuda, Akio, Matsuguchi, Tetsuya Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling. Blood 2005 105:711-20 PubMed ID: 15345588 DOI: 10.1182/blood-2004-03-0842

3365 Ito, Mikiko, Matsuka, Naoko, Izuka, Michiyo, Haito, Sakiko, Sakai, Yuko, Nakamura, Rie, Segawa, Hiroko, Kuwahata, Masashi, Yamamoto, Hironori, Pike, Wesley J, Miyamoto, Ken-ichi Characterization of inorganic phosphate transport in osteoclast-like cells. Am J Physiol Cell Physiol 2005 288:C921-31 PubMed ID: 15601753 DOI: 10.1152/ajpcell.00412.2004

3392 Aki, Daisuke, Mashima, Ryuichi, Saeki, Kazuko, Minoda, Yasumasa, Yamauchi, Moriyasu, Yoshimura, Akihiko Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages. Genes Cells 2005 10:357-68 PubMed ID: 15773898 DOI: 10.1111/j.1365-2443.2005.00839.x

3210 Hou, De-Xing, Yanagita, Takashi, Uto, Takuhiro, Masuzaki, Satoko, Fujii, Makoto Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem Pharmacol 2005 70:417-25 PubMed ID: 15963474 DOI: 10.1016/j.bcp.2005.05.003

3190 Hassan, Ferdaus, Islam, Shamima, Mu, Mya Mya, Ito, Hiroyasu, Koide, Naoki, Mori, Isamu, Yoshida, Tomoaki, Yokochi, Takashi Lipopolysaccharide prevents doxorubicin-induced apoptosis in RAW 264.7 macrophage cells by inhibiting p53 activation. Mol Cancer Res 2005 3:373-9 PubMed ID: 16046548 DOI: 10.1158/1541-7786.MCR-05-0046

3098 Suganami, Takayoshi, Nishida, Junko, Ogawa, Yoshihiro A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005 25:2062-2068 PubMed ID: 16123319 DOI: 10.1161/01.ATV.0000183883.72263.13

3209 Uto, Takuhiro, Fujii, Makoto, Hou, De-Xing 6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages. Biochem Pharmacol 2005 70:1211-21 PubMed ID: 16139249 DOI: 10.1016/j.bcp.2005.07.011

9122 Kobayashi Y, Mizoguchi T, Take I, Kurihara S, Udagawa N, Takahashi N. Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1. J. Biol. Chem. 2005 280:11395-403 PubMed ID: 15647289 DOI: 10.1074/jbc.M411189200

2919 Abe T, Hemmi H, Miyamoto H, Moriishi K, Tamura S, Takaku H, Akira S, Matsuura Y. Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. J Virol 2005 79(5):2847-58 PubMed ID: 15709004 DOI: 10.1128/JVI.79.5.2847-2858.2005

5921 Uto T, Fujii M, Hou DX. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 transcription by 6-(methylsulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages. Biochem Pharmacol 2005 70(12):1772-84 PubMed ID: 16256955 DOI: 10.1016/j.bcp.2005.09.023

6868 Hirata A, Murakami Y, Atsumi T, Shoji M, Ogiwara T, Shibuya K, Ito S, Yokoe I, Fujisawa S. Ferulic acid dimer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in macrophages. In Vivo 2005 19(5):849-53 PubMed ID: 16097437

6869 Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res 2005 25(5):3367-74 PubMed ID: 16101151

6873 Murakami Y, Ito S, Atsumi T, Fujisawa S. Theoretical prediction of the relationship between phenol function and COX-2/AP-1 inhibition for ferulic acid-related compounds. In Vivo 2005 19(6):1039-43 PubMed ID: 16277019

6874 Okada N, Hirata A, Murakami Y, Shoji M, Sakagami H, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds. Anticancer Res 2005 25(5):3263-9 PubMed ID: 16101137

6875 Atsumi T, Murakami Y, Shibuya K, Tonosaki K, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol. Anticancer Res 2005 25(6B):4029-36 PubMed ID: 16309195

12262 Tomohiro Konno, Hirokazu Hasuda, Kazuhiko Ishihara, Yoshihiro Ito Photo-immobilization of a phospholipid polymer for surface modification Biomaterials 2005 26(12):1381-8 PubMed ID: 15482825 DOI: 10.1016/j.biomaterials.2004.04.047

12263 Hirokazu Hasuda , Oh Hyeong Kwon, Inn-Kyu Kang, Yoshihiro Ito Synthesis of photoreactive pullulan for surface modification Biomaterials 2005 26(15):2401-6 PubMed ID: 15585243 DOI: 10.1016/j.biomaterials.2004.07.065

15385 Kyoko Watanabe Differentiation by LPS and IFN-γ of expression of adenosine receptors in macrophage cell lines RAW264 and J774 Pediatric Dental Journal 2005 15:43-51 DOI: 10.1016/s0917-2394(05)70028-8

15386 Koji Tatebayashi, Eiko Matsui, Hideo Kaneko, Toshiyuki Fukao, Kimiko Kasahara, Naomi Kondo IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity Allergology International 2005 54:451-459 DOI: 10.2332/allergolint.54.451

15387 Kurozumi R, Takahashi M, Kojima S. Involvement of mitochondrial peroxynitrite in nitric oxide-induced glutathione synthesis Biol Pharm Bull 2005 28(5):779-85 PubMed ID: 15863878 DOI: 10.1248/bpb.28.779

15388 Mario Casolaro, Eugenio Paccagnini, Raniero Mendichi, Yoshihiro Ito Stimuli-Responsive Polymers Based on l-Phenylalanine Residues: Protonation Thermodynamics of Free Polymers and Cross-Linked Hydrogels Macromolecules 2005 38:2460-2468 DOI: 10.1021/ma047652i

15389 Hatao F, Hiki N, Mimura Y, Ogawa T, Kojima J, Mafune K, Hawkins LD, Muroi M, Tanamoto K, Kaminishi M. The induction of super-resistance using synthetic lipopolysaccharide receptor agonist rescues fatal endotoxemia in rats without excessive immunosuppression Shock 2005 23(4):365-70 PubMed ID: 15803061 DOI: 10.1097/01.shk.0000158961.01456.b9

2890 Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages. Gene 2004 342:137-43 PubMed ID: 15527973 DOI: 10.1016/j.gene.2004.07.032

2904 Itoh CE, Kizaki T, Hitomi Y, Hanawa T, Kamiya S, Ookawara T, Suzuki K, Izawa T, Saitoh D, Haga S, Ohno H Down-regulation of beta2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation. Biochem Biophys Res Commun 2004 322:979-84 PubMed ID: 15336560 DOI: 10.1016/j.bbrc.2004.08.050

3200 Suzuki, Shogo, Nishimaki-Mogami, Tomoko, Tamehiro, Norimasa, Inoue, Kazuhide, Arakawa, Reijiro, Abe-Dohmae, Sumiko, Tanaka, Arowu R, Ueda, Kazumitsu, Yokoyama, Shinji Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. Arterioscler Thromb Vasc Biol 2004 24:519-25 PubMed ID: 14726413 DOI: 10.1161/01.ATV.0000117178.94087.ba

3229 Okuhira, Kei-ichiro, Tsujita, Maki, Yamauchi, Yoshio, Abe-Dohmae, Sumiko, Kato, Koichi, Handa, Tetsurou, Yokoyama, Shinji Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDL. J Lipid Res 2004 45:645-52 PubMed ID: 14729855 DOI: 10.1194/jlr.M300257-JLR200

3193 Ban, Hyun Seung, Suzuki, Katsuya, Lim, Soon Sung, Jung, Sang Hoon, Lee, Sanghyun, Ji, Jun, Lee, Hye Seung, Lee, Yeon Sil, Shin, Kuk Hyun, Ohuchi, Kazuo Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells. Biochem Pharmacol 2004 67:1549-57 PubMed ID: 15041472 DOI: 10.1016/j.bcp.2003.12.016

3212 Kato, Sawako, Yuzawa, Yukio, Tsuboi, Naotake, Maruyama, Shoichi, Morita, Yoshiki, Matsuguchi, Tetsuya, Matsuo, Seiichi Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. J Am Soc Nephrol 2004 15:1289-99 PubMed ID: 15100369

2688 Takahashi, Tetsuyuki, Takasuka, Nobuo, Iigo, Masaaki, Baba, Masaki, Nishino, Hoyoku, Tsuda, Hiroyuki, Okuyama, Toru Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci 2004 95:448-53 PubMed ID: 15132774 DOI: 10.1111/j.1349-7006.2004.tb03230.x

3220 Adachi, Yoshiyuki, Ishii, Takashi, Ikeda, Yoshihiko, Hoshino, Akiyoshi, Tamura, Hiroshi, Aketagawa, Jun, Tanaka, Shigenori, Ohno, Naohito Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Infect Immun 2004 72:4159-71 PubMed ID: 15213161 DOI: 10.1128/IAI.72.7.4159-4171.2004

3364 Hatao, Fumihiko, Muroi, Masashi, Hiki, Naoki, Ogawa, Toshihisa, Mimura, Yoshikazu, Kaminishi, Michio, Tanamoto, Ken-ichi Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. J Leukoc Biol 2004 76:904-8 PubMed ID: 15258191 DOI: 10.1189/jlb.0504277

3197 Matsumoto, Masahito, Kogawa, Masakazu, Wada, Seiki, Takayanagi, Hiroshi, Tsujimoto, Masafumi, Katayama, Shigehiro, Hisatake, Koji, Nogi, Yasuhisa Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J Biol Chem 2004 279:45969-79 PubMed ID: 15304486 DOI: 10.1074/jbc.M408795200

2865 Ikeda, Fumiyo, Nishimura, Riko, Matsubara, Takuma, Tanaka, Sakae, Inoue, Jun-ichiro, Reddy, Sakamuri V, Hata, Kenji, Yamashita, Kenji, Hiraga, Toru, Watanabe, Toshiyuki, Kukita, Toshio, Yoshioka, Katsuji, Rao, Anjana, Yoneda, Toshiyuki Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 2004 114:475-84 PubMed ID: 15314684 DOI: 10.1172/JCI19657

3135 Kimura T. et al. Novel PVA-DNA nanoparticles prepared by ultra high pressure technology for gene delivery. Materials Science and Engineering C 2004 24:797-801 DOI: 10.1016/j.msec.2004.08.046

6477 Ogasawara T, Katagiri M, Yamamoto A, Hoshi K, Takato T, Nakamura K, Tanaka S, Okayama H, Kawaguchi H. Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). J Bone Miner Res 2004 19(7):1128-36 PubMed ID: 15176996 DOI: 10.1359/jbmr.2004.19.7.1128

6737 Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H. Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells. Biochem Pharmacol 2004 67(1):119-27 PubMed ID: 14667934 DOI: 10.1016/j.bcp.2003.08.038

13881 Sato A, Keng VW, Yamamoto T, Kasamatsu S, Ban T, Tanaka H, Satoh S, Yamada K, Noguchi T. Identification and characterization of the hematopoietic cell-specific enhancer-like element of the mouse hex gene J Biochem 2004 135(2):259-68 PubMed ID: 15047729 DOI: 10.1093/jb/mvh031

14419 Nakamichi K, Inoue S, Takasaki T, Morimoto K, Kurane I. Rabies virus stimulates nitric oxide production and CXC chemokine ligand 10 expression in macrophages through activation of extracellular signal-regulated kinases 1 and 2 J Virol 2004 78(17):9376-88 PubMed ID: 15308732 DOI: 10.1128/JVI.78.17.9376-9388.2004

17339 Islam S, Hassan F, Mu MM, Ito H, Koide N, Mori I, Yoshida T, Yokochi T. Piceatannol prevents lipopolysaccharide (LPS)-induced nitric oxide (NO) production and nuclear factor (NF)-kappaB activation by inhibiting IkappaB kinase (IKK) Microbiol Immunol 2004 48(10):729-36 PubMed ID: 15502405 DOI: 10.1111/j.1348-0421.2004.tb03598.x

17341 Hassan F, Islam S, Koide N, Mu MM, Ito H, Mori I, Yoshida T, Yokochi T. Role of p38 mitogen-activated protein kinase (MAPK) for vacuole formation in lipopolysaccharide (LPS)-stimulated macrophages Microbiol Immunol 2004 48(11):807-15 PubMed ID: 15557738 DOI: 10.1111/j.1348-0421.2004.tb03612.x

6705 Murakami Y, Shoji M, Hanazawa S, Tanaka S, Fujisawa S. Preventive effect of bis-eugenol, a eugenol ortho dimer, on lipopolysaccharide-stimulated nuclear factor kappa B activation and inflammatory cytokine expression in macrophages. Biochem Pharmacol 2003 66(6):1061-6 PubMed ID: 12963494 DOI: 10.1016/s0006-2952(03)00419-2

15298 Kyoko Watanabe, Yasutaka Azuma, Shinya Shirasu, Michiharu Daito, Kiyoshi Ohura Alteration of the Expression of A 2 a Adenosine Receptor and Toll-like Receptor 4 in Macrophage Cell Lines. Japanese Journal of Oral Biology 2003 45:437-444 DOI: 10.2330/joralbiosci1965.45.437

2664 Kizaki, Takako, Suzuki, Kenji, Hitomi, Yoshiaki, Taniguchi, Naoyuki, Saitoh, Daizoh, Watanabe, Kenji, Onoe, Kazunori, Day, Noorbibi K, Good, Robert A, Ohno, Hideki Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A 2002 99:9392-7 PubMed ID: 12089332 DOI: 10.1073/pnas.142206299

2654 Muroi, Masashi, Tanamoto, Ken-Ichi The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4. Infect Immun 2002 70:6043-7 PubMed ID: 12379680 DOI: 10.1128/iai.70.11.6043-6047.2002

2521 Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 2002 17(5):583-91 PubMed ID: 12433365 DOI: 10.1016/s1074-7613(02)00446-6

2529 Yamamoto A, Miyazaki T, Kadono Y, Takayanagi H, Miura T, Nishina H, Katada T, Wakabayashi K, Oda H, Nakamura K, Tanaka S. Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand. J Bone Miner Res 2002 17(4):612-21 PubMed ID: 11918218 DOI: 10.1359/jbmr.2002.17.4.612

6686 Naraba H, Yokoyama C, Tago N, Murakami M, Kudo I, Fueki M, Oh-Ishi S, Tanabe T. Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1. J Biol Chem 2002 277(32):28601-8 PubMed ID: 12034740 DOI: 10.1074/jbc.M203618200

15299 Shibuya A, Wada K, Nakajima A, Saeki M, Katayama K, Mayumi T, Kadowaki T, Niwa H, Kamisaki Y. Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264 FEBS Lett 2002 525(1-3):43-7 PubMed ID: 12163159 DOI: 10.1016/s0014-5793(02)03059-4

15390 Tsuboi N, Yoshikai Y, Matsuo S, Kikuchi T, Iwami K, Nagai Y, Takeuchi O, Akira S, Matsuguchi T. Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells J Immunol 2002 169(4):2026-33 PubMed ID: 12165529 DOI: 10.4049/jimmunol.169.4.2026

15391 Shuji Kojima, Risa Kurozumi, Maiko Tuchiya A New Functional Role of 5,6,7,8-tetrahydrobiopterin (BH4) as an Inhibitor of γ-glutamylcysteine Synthetase (γ-GCS) mRNA Expression pteridines 2002 13:83-88 DOI: 10.1515/pteridines.2002.13.3.83

15392 Risa Kurozumi, Shuji Kojima Low-level Nitric Oxide Blunts Oxidant Injury via Up-regulating Glutathione Synthes. Journal of Health Science 2002 48:140-147 DOI: 10.1248/jhs.48.140

17295 Wakabayashi I, Yasui K, Negoro M. Diverse effects of ethanol on the pathway of inducible prostaglandin E2 production in macrophages Prostaglandins Other Lipid Mediat 2002 ;67(1):61-74 PubMed ID: 11789898 DOI: 10.1016/s0090-6980(01)00176-9

2504 Haruta I, Kato Y, Hashimoto E, Minjares C, Kennedy S, Uto H, Yamauchi K, Kobayashi M, Yusa S, Muller U, Hayashi N, Miyazaki T Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages. J Biol Chem 2001 276:22910-4 PubMed ID: 11294859 DOI: 10.1074/jbc.M100324200

2973 Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. Immunogenetics 2001 53:649-55 PubMed ID: 11797098 DOI: 10.1007/s00251-001-0376-x

18566 Takahashi F, Takahashi K, Okazaki T, Maeda K, Ienaga H, Maeda M, Kon S, Uede T, Fukuchi Y. Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis Am J Respir Cell Mol Biol 2001 24(3):264-71 PubMed ID: 11245625 DOI: 10.1165/ajrcmb.24.3.4293

3777 Arima H, Kihara F, Hirayama F, Uekama K. Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins. Bioconjug Chem 2001 12(4):476-84 PubMed ID: 11459450 DOI: 10.1021/bc000111n

6657 Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 2001 166(5):3574-9 PubMed ID: 11207318 DOI: 10.4049/jimmunol.166.5.3574

9033 E Noiri, A Nakao, K Uchida, H Tsukahara, M Ohno, T Fujita, S Brodsky, M S Goligorsky Oxidative and Nitrosative Stress in Acute Renal Ischemia Am J Physiol Renal Physiol 2001 281 (5), F948-57 PubMed ID: 11592952 DOI: 10.1152/ajprenal.2001.281.5.F948

15393 Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, Mano H, Hirasawa H, Tokuhisa T. Isoform-dependent interaction of BRDG1 with Tec kinase Biochem Biophys Res Commun 2001 289(2):414-20 PubMed ID: 11716489 DOI: 10.1006/bbrc.2001.6008

15394 Aramaki Y, Takano S, Tsuchiya S. Cationic liposomes induce macrophage apoptosis through mitochondrial pathway Arch Biochem Biophys 2001 392(2):245-50 PubMed ID: 11488598 DOI: 10.1006/abbi.2001.2458

15395 Takano S, Aramaki Y, Tsuchiya S. Lipoxygenase may be involved in cationic liposome-induced macrophage apoptosis Biochem Biophys Res Commun 2001 288(1):116-20 PubMed ID: 11594761 DOI: 10.1006/bbrc.2001.5731

15396 Matsumoto M, Hisatake K, Nogi Y, Tsujimoto M. Regulation of receptor activator of NF-kappaB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factor J Biol Chem 2001 276(35):33086-92 PubMed ID: 11425859 DOI: 10.1074/jbc.M104299200

15397 Matsuguchi T, Musikacharoen T, Johnson TR, Kraft AS, Yoshikai Y. A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines Mol Cell Biol 2001 21(20):6999-7009 PubMed ID: 11564882 DOI: 10.1128/MCB.21.20.6999-7009.2001

15623 Ke X, Terashima M, Nariai Y, Nakashima Y, Nabika T, Tanigawa Y. Nitric oxide regulates actin reorganization through cGMP and Ca(2+)/calmodulin in RAW 264.7 cells Biochim Biophys Acta 2001 1539(1-2):101-13 PubMed ID: 11389972 DOI: 10.1016/s0167-4889(01)00090-8

16918 Van Dien M, Takahashi K, Mu MM, Koide N, Sugiyama T, Mori I, Yoshida T, Yokochi T. Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice Microbiol Immunol 2001 45(11):751-6 PubMed ID: 11791668 DOI: 10.1111/j.1348-0421.2001.tb01311.x

3224 Abe-Dohmae S, Suzuki S, Wada Y, Aburatani H, Vance, D E, Yokoyama S Characterization of apolipoprotein-mediated HDL generation induced by cAMP in a murine macrophage cell line. Biochemistry 2000 39:11092-9 PubMed ID: 10998247 DOI: 10.1021/bi0008175

3225 Suzuki S, Abe-Dohmae S, Fukutomi T, Ito S, Itoh M, Yokoyama S Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. J Cardiovasc Pharmacol 2000 36:609-16 PubMed ID: 11065221 DOI: 10.1097/00005344-200011000-00010

3991 Matsumoto M, Sudo T, Maruyama M, Osada H, Tsujimoto M. Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor. FEBS Lett 2000 486(1):23-8 PubMed ID: 11108836 DOI: 10.1016/s0014-5793(00)02231-6

3994 Iwahashi H, Takeshita A, Hanazawa S. Prostaglandin E2 stimulates AP-1-mediated CD14 expression in mouse macrophages via cyclic AMP-dependent protein kinase A. J Immunol 2000 164(10):5403-8 PubMed ID: 10799905 DOI: 10.4049/jimmunol.164.10.5403

3531 Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem 2000 275(40):31155-61 PubMed ID: 10859303 DOI: 10.1074/jbc.M001229200

15403 Hiroyuki Iizuka, Hirofumi Sagara, Shuji Kojima Modulation of LPS-induced Cell Death by 5,6,7,8-Tetrahydrobiopterin pteridines 1999 10:202-206 DOI: 10.1515/pteridines.1999.10.4.202

15405 Keiichiro Yoshida, Michio Ono, Hajime Sawada Lipopolysaccharide-induced vacuoles in macrophages: Their origin is plasma membrane-derived organelles and endoplasmic reticulum, but not lysosomes Journal of Endotoxin Research 1999 5:127-137 DOI: 10.1177/09680519990050030601

2423 Okada S, Zhang H, Hatano M, Tokuhisa T A physiologic role of Bcl-xL induced in activated macrophages. J Immunol 1998 160:2590-6 PubMed ID: 9510156

15402 Yoko Ishihara Norihiko Kohyama Atsu CELLULAR BIOLOGICAL EFFECTS AND A SINGLE TRANSTRACHEAL INJECTION TEST IN THREE TYPES OF WHISKER FIBERS Inhalation Toxicology 1998 10:275-291 DOI: 10.1080/089583798197682

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18026 Adachi Y, Okazaki M, Ohno N, Yadomae T. Leukocyte activation by (1-->3)-beta-D glucans Mediators Inflamm 1997 6(4):251-6 PubMed ID: 18472853 DOI: 10.1080/09629359791569

18030 Hirano S, Ando M. Fluoride mediates apoptosis in osteosarcoma UMR 106 and its cytotoxicity depends on the pH Arch Toxicol 1997 72(1):52-8 PubMed ID: 9458191 DOI: 10.1007/s002040050468

18074 Miura T, Ohno N, Miura NN, Shimada S, Yadomae T. Inactivation of a particle beta-glucan by proteins in plasma and serum Biol Pharm Bull 1997 20(10):1103-7 PubMed ID: 9353573 DOI: 10.1248/bpb.20.1103

15398 Ohata T, Fukuda K, Takahashi M, Sugimura T, Wakabayashi K. Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids Jpn J Cancer Res 1997 88(3):234-7 PubMed ID: 9140106 DOI: 10.1111/j.1349-7006.1997.tb00372.x

15399 Iwamoto N, Ito K, Kakuchi J, Yoshioka T. Quenching of nitric oxide by an oral carbonaceous adsorbent Jpn J Pharmacol 1997 74(2):213-6 PubMed ID: 9243331 DOI: 10.1254/jjp.74.213

15400 Arima H, Aramaki Y, Tsuchiya S. Contribution of trypsin-sensitive proteins to binding of cationic liposomes to the mouse macrophage-like cell line RAW264.7 J Pharm Sci 1997 86(7):786-90 PubMed ID: 9232517 DOI: 10.1021/js960530m

17244 Izumi S, Ohno N, Kawakita T, Nomoto K, Yadomae T. Wide range of molecular weight distribution of mitogenic substance(s) in the hot water extract of a Chinese herbal medicine, Bupleurum chinense Biol Pharm Bull 1997 20(7):759-64 PubMed ID: 9255416 DOI: 10.1248/bpb.20.759

17987 Rie SUZUKI， Toshitaka KIDO， Naoko MIURA， Masahiro YAMAMOTO， Yasuhiro KOMATSU and Kazunori FUKUDA Inhibitory effects of herbal medicines on nitric oxide production in macrophage and hepatoma cell lines induced by inflammatory stimuli Journal of Traditional Medicines 1996 13:165-172

18008 Asai K, Kato H, Kimura S, Mukai S, Kawahito Y, Sano H, Kondo M, Akaogi K, Hirose K. Induction of gene expression for nitric oxide synthase by immunomodulating drugs in the RAW264.7 murine macrophage cell line Cancer Immunol Immunother 1996 42(5):275-9 PubMed ID: 8706048 DOI: 10.1007/s002620050282

18010 Kanematsu M, Takagi K, Masuda N, Suketa Y. Lead inhibits nitric oxide production transiently by mRNA level in murine macrophage cell lines Biol Pharm Bull 1996 19(7):949-51. PubMed ID: 8839967 DOI: 10.1248/bpb.19.949

18019 Suzuki T, Ohno N, Chiba N, Miura NN, Adachi Y, Yadomae T. Immunopharmacological activity of the purified insoluble glucan, zymocel, in mice J Pharm Pharmacol 1996 48(12):1243-8 PubMed ID: 9004185 DOI: 10.1111/j.2042-7158.1996.tb03930.x

14430 Yoshimoto T, Kojima K, Funakoshi T, Endo Y, Fujita T, Nariuchi H. Molecular cloning and characterization of murine IL-12 genes J Immunol 1996 156(3):1082-8 PubMed ID: 8557982

17952 Joto N, Akimoto T, Someya K, Tohgo A. Production of tumor necrosis factor induced by synthetic low-toxicity lipid A analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase-MAP kinase signaling pathway in murine macrophages Cell Immunol 1995 160(1):1-7 PubMed ID: 7531115 DOI: 10.1016/0008-8749(95)80002-z

17975 Okazaki M, Adachi Y, Ohno N, Yadomae T. Structure-activity relationship of (1-->3)-beta-D-glucans in the induction o Biol Pharm Bull 1995 18(10):1320-7 PubMed ID: 8593430 DOI: 10.1248/bpb.18.1320

15401 K. Takada, N. Ohno, T. Yadomae Physicochemical and biological characterizations of complex formation between lipopolysaccharide and lysozyme Journal of Endotoxin Research 1995 2:255-262 DOI: 10.1177/096805199500200405

17926 Adachi Y, Okazaki M, Ohno N, Yadomae T. Enhancement of cytokine production by macrophages stimulated with (1-->3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa Biol Pharm Bull 1994 17(12):1554-60 PubMed ID: 7537572 DOI: 10.1248/bpb.17.1554

1645 Tanida N, Ohno N, Adachi Y, Matsuura M, Nakano M, Kiso M, Hasegawa A, Yadomae T Modification of Immunopharmacologicaln Activities of Synthetic Monosaccharide Lipid A Analogue, GLA60, by Lysozyme J Biochem 1992 112:616-623 PubMed ID: 1478920 DOI: 10.1093/oxfordjournals.jbchem.a123949