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Cell No. : Cell Name
RCB0500 : HGC-27  update : 2023/08/16
CommentHuman cell line derived from metastatic lymph node of gastric cancer (undifferentiated carcinoma).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Kimoto, Tetsuo
Originator Akagi, Tadaatsu
Year of deposit 1990
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Age at sampling adult
Tissue stomach, lymph node meta
Disease name gastric cancer
Metastastatic ability Yes
Metastatsd tissue lymph node
Classification cancer
Year of origin 1973
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1279
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 67-76(50) : 69(7),70(7),71(12),72(7),73(4),74(4)/
STR(human) OK
deposit info
lot info
Reference information Reference 5
User's Publication 89

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30  Yokota K, Kobayashi K, Kawahara Y, Hayashi S, Hirai Y, Mizuno M, Okada H, Akagi T, Tsuji T, Oguma K.  A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression  Biol Chem  2021  402(6):663-674  PubMed ID: 33544466   DOI: 10.1515/hsz-2020-0355
28  Yokota K, Ayada K, Ishii E, Oguma K, Yamasaki R, Kobayashi K, Yoshino T, Akagi T, Hayashi S, Hirai Y.  Gastric mucosal immunity induced by H. pylori infection  Nihon Rinsho  2001  59(2):342-8  PubMed ID: 11218410  
29  Yokota K, Kobayashi K, Kawahara Y, Hayashi S, Hirai Y, Mizuno M, Okada H, Akagi T, Tsuji T, Oguma K.  Gastric ulcers in SCID mice induced by Helicobacter pylori infection after transplanting lymphocytes from patients with gastric lymphoma  Gastroenterology  1999  117(4):893-9  PubMed ID: 10500072   DOI: 10.1016/s0016-5085(99)70348-3
27  Akagi T, Yoshino T, Motoi M, Takata H, Yano S, Miyoshi I, Oka T, Ohtsuki Y.  Isolation of virus-producing transformants from human gastric cancer cell line, HGC-27, infected with human T-cell leukemia virus type I  Jpn J Cancer Res  1988  79(7):836-42  PubMed ID: 3139597   DOI: 10.1111/j.1349-7006.1988.tb00045.x
1281  Akagi T, Kimoto T  Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer.  Acta Med Okayama  1976  30:215-9  PubMed ID: 136873  

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User's Publication
17775  Yusuke Takizawa*, Koume Yoda, Miho Ishii, Yuka Nagai, Takuro Kurita, Takanori Nakajima  The influence of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI) in caramel coloring III on gastrointestinal epithelial cells  J. Excipients and Food Chem  2023  14:22-32   
18073  Nor Azlin Safina Abdul Aziz, Maslinda Musa, Siti Hamimah Sheikh Abdul Kadir, Zeti Rahayu Abdul Karim, Narimah Abdul Hamid Hasani  Overexpression of Bactericidal/Permeability-Increasing Fold-Containing Family BPIFB1 in Gastric Cancer Cells Leads to Differential Expression of E-Cadherin and MUC5AC  Biology Bulletin  2023      DOI: 10.1134/s1062359022601756
21269  Saito-Adachi M, Hama N, Totoki Y, Nakamura H, Arai Y, Hosoda F, Rokutan H, Yachida S, Kato M, Fukagawa A, Shibata T.  Oncogenic structural aberration landscape in gastric cancer genomes.  Nat Commun  2023  14(1):3688  PubMed ID: 37349325   DOI: 10.1038/s41467-023-39263-1
21361  Wu C, Li D, Cheng X, Gu H, Qian Y, Feng L.  Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer cells via immunoglobulin domain-containing 1/zonula occluden-1 axis.  Cell Cycle  2023  1-20  PubMed ID: 37587724   DOI: 10.1080/15384101.2023.2231740
17567  Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer  Cancer Sci  2022  113(6):1984-1998  PubMed ID: 35307915   DOI: 10.1111/cas.15342
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20633  Chen Y, Jiang L, Xia L, Zhang G, Chen L.  ThPOK inhibits the immune escape of gastric cancer cells by inducing STPG1 to inactivate the ERK pathway.  BMC Immunol  2022  23(1):16  PubMed ID: 35379170   DOI: 10.1186/s12865-022-00485-5
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
16737  Yusuke Takizawa, Junya Oguri, Masaya Uno, Ami Onsui, Atsushi Ishimura, Takuro Kurita, Takanori Nakajima  Effects of A GLP‑1 Receptor Agonist on Gastrointestinal Epithelial Cells  Scholars Academic Journal of Pharmacy  2022  11:60-66    DOI: 10.36347/sajp.2022.v11i04.002
17107  Liu B, Katoh H, Komura D, Yamamoto A, Ochi M, Onoyama T, Abe H, Ushiku T, Seto Y, Suo J, Ishikawa S.  Functional genomics screening identifies aspartyl-tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers  J Pathol  2022  2022 Jun 13  PubMed ID: 35696251   DOI: 10.1002/path.5980
20908  Wang X, Zhang L, Liang Q, Wong CC, Chen H, Gou H, Dong Y, Liu W, Li Z, Ji J, Yu J.  DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance.  Oncogenesis  2022  11(1):66  PubMed ID: 36307394   DOI: 10.1038/s41389-022-00441-3
17777  Yusuke Takizawa*, Mizuki Arakawa, Takuro Kurita, Takanori Nakajima  The influence of 4-methylimidazole on the gastrointestinal epithelial cells  J. Excipients and Food Chem  2021  12:4-15   
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
20127  Chen R, Masuo K, Yogo A, Yokoyama S, Sugiyama A, Seno H, Yoshizawa A, Takaishi S.  SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.  Carcinogenesis  2021  42(2):190-201  PubMed ID: 33313663   DOI: 10.1093/carcin/bgaa133
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
20224  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E.  Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer.  Photodiagnosis Photodyn Ther  2021    PubMed ID: 34242818   DOI: 10.1016/j.pdpdt.2021.102420
20275  Gao F, Chen X, Lu J, Hu S, Xu H, Shi Y, Feng M, Ding J, Liu H, Luo C, Xie Z, Wang J.  Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer.  Eur J Med Chem  2021  215:113274  PubMed ID: 33592537   DOI: 10.1016/j.ejmech.2021.113274
20358  Zhang J, Wang F, Zhang H, Cao M.  A novel circular RNA circ_HN1/miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network regulates gastric cancer development.  Bioengineered  2021    PubMed ID: 34637682   DOI: 10.1080/21655979.2021.1989259
20415  Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T.  Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.  Oncol Lett  2021  22(4):735  PubMed ID: 34466148   DOI: 10.3892/ol.2021.12996
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
9737  Tomohiro Kohmoto, Kiyoshi Masuda, Katsutoshi Shoda, Rizu Takahashi, Sae Ujiro, Shoichiro Tange, Daisuke Ichikawa, Eigo Otsuji, Issei Imoto  Claudin-6 Is a Single Prognostic Marker and Functions as a Tumor-Promoting Gene in a Subgroup of Intestinal Type Gastric Cancer  Gastric Cancer  2020  23(3):403-417  PubMed ID: 31654186   DOI: 10.1007/s10120-019-01014-x
12060  Nishibeppu K, Komatsu S, Imamura T, Kiuchi J, Kishimoto T, Arita T, Kosuga T, Konishi H, Kubota T, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.  Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.  Sci Rep  2020    PubMed ID: 32081926   DOI: 10.1038/s41598-020-59939-8
13454  Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh  Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro  Personalized Medicine Universe  2020      DOI: 10.46459/pmu.2020001
14804  Xing M, Ooi WF, Tan J, Qamra A, Lee PH, Li Z, Xu C, Padmanabhan N, Lim JQ, Guo YA, Yao X, Amit M, Ng LM, Sheng T, Wang J, Huang KK, Anene-Nzelu CG, Ho SWT, Ray M, Ma L, Fazzi G, Lim KJ, Wijaya GC, Zhang S, Nandi T, Yan T, Chang MM, Das K, Isa ZFA, Wu J, Poon PSY, Lam YN, Lin JS, Tay ST, Lee MH, Tan ALK, Ong X, White K, Rozen SG, Beer M, Foo RSY, Grabsch HI, Skanderup AJ, Li S, Teh BT, Tan P.  Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer  J Clin Invest  2020  130(6):3005-3020  PubMed ID: 32364535   DOI: 10.1172/JCI126726
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826   DOI: 10.1038/s41586-019-1103-9
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
12282  Taslima T Lina, Jazmin Gonzalez, Irina V Pinchuk, Ellen J Beswick, Victor E Reyes  Helicobacter pylori elicits B7H3 expression on gastric epithelial cells: Implications in local T cell regulation and subset development during infection  Clin Oncol Res  2019  2(5)  PubMed ID: 31998864   DOI: 10.31487/j.cor.2019.05.05
12448  Zhang B, Zhang X, Jin M, Hu L, Zang M, Qiu W, Wang S, Liu B, Liu S, Guo D.  CagA increases DNA methylation and decreases PTEN expression in human gastric cancer  Mol Med Rep  2019  19(1):309-319  PubMed ID: 30431097   DOI: 10.3892/mmr.2018.9654
10725  Nakamura A, Matsunaga W, Gotoh A.  Autophagy Induced by Naftopidil Inhibits Apoptosis of Human Gastric Cancer Cells.  Anticancer Res.  2018  38:803-809  PubMed ID: 29374705   DOI: 10.21873/anticanres.12287
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864   DOI: 10.3892/or.2017.6093
4313  Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.  Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.  Am J Cancer Res  2018    PubMed ID: 30662802  
14272  Krishnan V, Chong YL, Tan TZ, Kulkarni M, Bin Rahmat MB, Tay LS, Sankar H, Jokhun DS, Ganesan A, Chuang LSH, Voon DC, Shivashankar GV, Thiery JP, Ito Y.  TGFβ Promotes Genomic Instability after Loss of RUNX3  Cancer Res  2018  78(1):88-102  PubMed ID: 29074538   DOI: 10.1158/0008-5472.CAN-17-1178
14733  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma  Carcinogenesis  2018  39(2):263-271  PubMed ID: 29228320   DOI: 10.1093/carcin/bgx139
9978  Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, Zwingenberger G, Weichert W, Luber B.  Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.  J. Cancer Res. Clin. Oncol.  2017  143:573-600  PubMed ID: 27933395   DOI: 10.1007/s00432-016-2308-z
10112  Asano M, Sakaguchi M, Tanaka S, Kashimura K, Mitani T, Kawase M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.  Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator.  Sci Rep  2017  7:41244  PubMed ID: 28145466   DOI: 10.1038/srep41244
10652  Lin Z, Lai S, He X, Zhuo W, Wang L, Si J, Chen S.  Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F.  Oncotarget  2017  8:97371-97383  PubMed ID: 29228617   DOI: 10.18632/oncotarget.22126
5804  Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki  Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26  Oncology Letters  2017  13(1):215-221  PubMed ID: 28123544   DOI: 10.3892/ol.2016.5386
14271  Muguruma N, Okamoto K, Nakagawa T, Sannomiya K, Fujimoto S, Mitsui Y, Kimura T, Miyamoto H, Higashijima J, Shimada M, Horino Y, Matsumoto S, Hanaoka K, Nagano T, Shibutani M, Takayama T.  Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1  Sci Rep  2017  7(1):6536  PubMed ID: 28747791   DOI: 10.1038/s41598-017-06857-x
14619  Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E.  Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer  Oncotarget  2017  8(60):101394-101405  PubMed ID: 29254173   DOI: 10.18632/oncotarget.20736
14744  Ohashi T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Imamura T, Kiuchi J, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma  Br J Cancer  2017  116(2):218-226  PubMed ID: 27898655   DOI: 10.1038/bjc.2016.394
5811  Maejima R et al  Enhanced expression of semaphorin 3E is involved in the gastric cancer development.  Int J Oncol  2016  49(3):887-94  PubMed ID: 27572291   DOI: 10.3892/ijo.2016.3593
5812  Hirashita Y et al  Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells.  Cancer Sci  2016  107(12):1919-1928  PubMed ID: 27699948   DOI: 10.1111/cas.13094
14170  Koichiro Hayashi, Wataru Sakamoto, Toshinobu Yogo  Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI-Guided Local Magnetic Thermochemotherapy  Advanced Functional Materials  2016  26:1708-1718    DOI: 10.1002/adfm.201504215
7458  Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK.  An integrative approach identified genes associated with drug response in gastric cancer.  Carcinogenesis  2015  36:441-51  PubMed ID: 25742747   DOI: 10.1093/carcin/bgv014
14961  Angiopoietin-like protein 2 is a potential biomarker for gastric cancer  Angiopoietin-like protein 2 is a potential biomarker for gastric cancer  Molecular Medicine Reports  2015  11:2653-2658  PubMed ID: 25484242   DOI: 10.3892/mmr.2014.3040
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
15244  Lina TT, Alzahrani S, House J, Yamaoka Y, Sharpe AH, Rampy BA, Pinchuk IV, Reyes VE.  Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion  PLoS One  2015  10(3):e0121841  PubMed ID: 25807464   DOI: 10.1371/journal.pone.0121841
5833  Sato M, Muguruma N, Nakagawa T, Okamoto K, Kimura T, Kitamura S, Yano H, Sannomiya K, Goji T, Miyamoto H, Okahisa T, Mikasa H, Wada S, Iwata M, Takayama T.  High antitumor activity of pladienolide B and its derivative in gastric cancer.  Cancer Sci  2014  105(1):110-6  PubMed ID: 24635824   DOI: 10.1111/cas.12317
6335  Matsumoto H, Tsuchiya T, Yoshiura K, Hayashi T, Hidaka S, Nanashima A, Nagayasu T.  ABCC11/MRP8 Expression in the Gastrointestinal Tract and a Novel Role for Pepsinogen Secretion.  Acta Histochem Cytochem  2014  47(3):85-94  PubMed ID: 25320405   DOI: 10.1267/ahc.13040
17146  Fawzy A. Attaby, Azza M. Abdel-Fattah, Labeeb M. Shaif, Mohamed M. Elsayed  Synthesis, Reactions, Characterization and Biological Evaluation of 2,3′-Bipyridine Derivatives (III)  Journal of Heterocyclic Chemistry  2014  51:927-936    DOI: 10.1002/jhet.1521
18077  Shiho Sakuma, Eiko Otake, Kan Torii, Motoki Nakamura, Akira Maeda, Ryoto Tujii, Haruo Akashi, Hiromi Ohi, Shigenobu Yano, Akimichi Morita  Photodynamic therapy with glycoconjugated chlorin photosensitizer  Journal of Porphyrins and Phthalocyanines  2013  17:331-342    DOI: 10.1142/S1088424613500065
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082   DOI: 10.1371/journal.pone.0056766
14697  Lina TT, Pinchuk IV, House J, Yamaoka Y, Graham DY, Beswick EJ, Reyes VE.  CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection  J Immunol  2013  191(7):3838-46  PubMed ID: 23997227   DOI: 10.4049/jimmunol.1300524
5850  Miyato H, Tsuno NH, Kitayama J.  Semaphorin 3C is involved in the progression of gastric cancer.  Cancer Sci  2012  103(11):1961-6  PubMed ID: 22924992   DOI: 10.1111/cas.12003
6316  Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F.  Identification of a potent epigenetic biomarker for resistance to camptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer.  Int J Oncol  2012  40(1):217-26  PubMed ID: 21901246   DOI: 10.3892/ijo.2011.1189
5860  Du L, Xiao X, Wang C, Zhang X, Zheng N, Wang L, Zhang X, Li W, Wang S, Dong Z.  Human leukocyte antigen-G is closely associated with tumor immune escape in gastric cancer by increasing local regulatory T cells.  Cancer Sci  2011  102(7):1272-80  PubMed ID: 21466615   DOI: 10.1111/j.1349-7006.2011.01951.x
5871  Galal SA, Hegab KH, Hashem AM, Youssef NS  Synthesis and antitumor activity of novel benzimidazole-5-carboxylic acid derivatives and their transition metal complexes as topoisomerease II inhibitors.  Eur J Med Chem   2010  45(12):5685-91  PubMed ID: 20884089   DOI: 10.1016/j.ejmech.2010.09.023
16973  Riyadh SM, Farghaly TA, Abdallah MA, Abdalla MM, Abd El-Aziz MR.  New pyrazoles incorporating pyrazolylpyrazole moiety: synthesis, anti-HCV and antitumor activity  Eur J Med Chem  2010  45(3):1042-50  PubMed ID: 20022411   DOI: 10.1016/j.ejmech.2009.11.050
8590  Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, Nagawa H.  Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.  J. Surg. Res.  2009  155:40-7  PubMed ID: 19394652   DOI: 10.1016/j.jss.2008.06.045
5878  Abdel-Fattah, Azza M.; Elsayed, Mohamed M.  Novel Synthesis, Reactions and anti-Cancer Activities of 4,4'-Benzene-1,4- diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile)  Current Organic Chemistry  2009  13:1751-1757   
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