細胞番号 : 細胞名
RCB0495 : KU812
update : 2022/03/16
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| 細胞特性(Comment:英) | Chronic myelogeneous leukemia, Ph1 chromosome (+), basophil-like cells. |
| 細胞特性(日) | 幼若好塩基球と考えられる慢性骨髄性白血病細胞。赤芽球への分化も見られる。RCB0496 KU812E、RCB0497 KU812Fの親株。 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Mizusawa, Hiroshi
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| 樹立者 |
Kishi, Kenji
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| 寄託日 |
1990
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| 動物種 |
human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 性別 |
Male
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| 採取組織 |
blood
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| 細胞分類 |
cancer
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| 入手歴 |
JCRB0104
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細胞寿命 |
infinite
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| 細胞形態 |
lymphocyte-like
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| Cellosaurus(Expasy) |
CVCL_0379
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Suspension cells
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| 培地 |
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RPMI1640 + 10% FBS
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| 抗生物質 |
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Free
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継代方法 |
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dilution
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|
継代密度 |
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1 : 10 split
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| 継代・培地交換頻度 |
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Subculture : 2 times/week
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| 培養最適温度 |
|
37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ |
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(-)
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| ウィルス（HIV) |
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(-)
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| ウィルス（HTLV-1) |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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50-108(50) : /58(1),59(4),60(8),61(5),62(5),63(9)/
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| 個体識別検査 |
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OK
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| 画像情報 |
寄託時情報 | ロット情報 |
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| 文献情報 |
Reference(英) |
8件
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| Reference(日) |
0件
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| 利用者成果(英) |
16件
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| 利用者成果(日) |
0件
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| Reference(英) |
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25
Sato N, Kishi K, Toba K, Watanabe K, Itoh H, Narita M, Takahashi M, Aizawa Y.
Simultaneous expression of CD13, CD22 and CD25 is related to the expression of Fc epsilon R1 in non-lymphoid leukemia
Leuk Res
2004
28(7):691-8
PubMed ID: 15158090
DOI: 10.1016/j.leukres.2003.10.034
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21
Fukuda T, Kamishima T, Tsuura Y, Suzuki T, Kakihara T, Naito M, Kishi K, Matsumoto K, Shibata A, Seito T.
Expression of the c-kit gene product in normal and neoplastic mast cells but not in neoplastic basophil/mast cell precursors from chronic myelogenous leukaemia
J Pathol
1995
177(2):139-46
PubMed ID: 7490680
DOI: 10.1002/path.1711770207
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1796
Valent P, Besemer J, Sillaber C, Butterfield, J H, Eher R, Majdic O, Kishi K, Klepetko W, Eckersberger F, Lechner K, et al.
Failure to detect IL-3-binding sites on human mast cells.
J Immunol
1990
145:3432-7
PubMed ID: 2230127
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1795
Nakazawa M, Mitjavila, M T, Debili N, Casadevall N, Mayeux P, Rouyer-Fessard P, Dubart A, Romeo, P H, Beuzard Y, Kishi K, et al.
KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation.
Blood
1989
73:2003-13
PubMed ID: 2540861
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1774
Fischkoff SA, Kishi K, Benjamin WR, Rossi RM, Hoessly MC, Hoxie JA, Seals C, Anderson L, Ishizaka T, Hakimi J.
Induction of differentiation of the human leukemia cell line, KU812.
Leuk Res
1987
11(12):1105-13
PubMed ID: 3695564
DOI: 10.1016/0145-2126(87)90164-0
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1765
Fukuda T, Kishi K, Ohnishi Y, Shibata A.
Bipotential cell differentiation of KU-812: evidence of a hybrid cell line that differentiates into basophils and macrophage-like cells.
Blood
1987
70(3):612-9
PubMed ID: 3304457
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1785
Kishi K.
A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors.
Leuk Res
1985
9(3):381-90
PubMed ID: 3858609
DOI: 10.1016/0145-2126(85)90060-8
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1784
Kishi K, Takahashi M, Aoki S, Nagai K, Hirosawa H, Koike T, Sakai C, Aoyagi Y, Sanada M, Moriyama Y, et al.
A new Ph1 positive cell line (KU812) from a patient with blastic crisis of chronic myelogenous leukemia
Nihon Ketsueki Gakkai Zasshi
1984
47(3):709-18
PubMed ID: 6591673
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| 利用者成果(英) |
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17652
Tatsuki Shibuta, Honoka Shimizu, Yukichi Takada, Asuka Fuku, Satoshi Tomiyasu, Tsukuru Umemura
miR-494 in Extracellular Vesicles as a Potent Biomarker of Chronic Myeloid Leukemia Treatment with Tyrosine Kinase Inhibitors
Hemato
2022
3:373-384
DOI: 10.3390/hemato3020026
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12497
Watanabe D, Nogami A, Okada K, Akiyama H, Umezawa Y, Miura O.
FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM
Cancers (Basel)
2019
11(12):1827
PubMed ID: 31756944
DOI: 10.3390/cancers11121827
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7368
Liao EC, Chang CY, Hsieh CW, Yu SJ, Yin SC, Tsai JJ.
An Exploratory Pilot Study of Genetic Marker for IgE-Mediated Allergic Diseases with Expressions of FcεR1α and Cε.
Int J Mol Sci
2015
16:9504-19
PubMed ID: 25923080
DOI: 10.3390/ijms16059504
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15072
Tang Y, Abe N, Yoshimoto M, Zhu B, Murata Y, Nakamura Y.
Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells
Biosci Biotechnol Biochem
2015
79(1):159-63
PubMed ID: 25253661
DOI: 10.1080/09168451.2014.963503
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7936
Motojima H, O Villareal M, Han J, Isoda H.
Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid.
Cytotechnology
2011
63:181-90
PubMed ID: 21331654
DOI: 10.1007/s10616-010-9333-6
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8071
Yamada P, Nemoto M, Shigemori H, Yokota S, Isoda H.
Isolation of 5-(hydroxymethyl)furfural from Lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells.
Planta Med.
2011
77:434-40
PubMed ID: 21031336
DOI: 10.1055/s-0030-1250402
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8314
Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H.
Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells.
Planta Med.
2010
76:1512-8
PubMed ID: 20354949
DOI: 10.1055/s-0030-1249775
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8529
Wu H, Qi H, Iwasaki D, Zhu B, Shimoishi Y, Murata Y, Nakamura Y.
JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812 cells.
Free Radic. Biol. Med.
2009
47:1028-38
PubMed ID: 19607912
DOI: 10.1016/j.freeradbiomed.2009.07.011
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12784
Yamada P, Zarrouk M, Kawasaki K, Isoda H.
Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells
J Ethnopharmacol
2008
116(2):279-87
PubMed ID: 18178046
DOI: 10.1016/j.jep.2007.11.028
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16902
Fujita K, Tsujimura A, Miyagawa Y, Kiuchi H, Matsuoka Y, Takao T, Takada S, Nonomura N, Okuyama A.
Isolation of germ cells from leukemia and lymphoma cells in a human in vitro model: potential clinical application for restoring human fertility after anticancer therapy
Cancer Res
2006
66(23):11166-71
PubMed ID: 17145860
DOI: 10.1158/0008-5472.CAN-06-2326
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3164
Takamatsu, Shinji, Inoue, Noboru, Katsumata, Toshiyuki, Nakamura, Katsumi, Fujibayashi, Yasuhisa, Takeuchi, Makoto
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
Biochemistry
2005
44:6343-9
PubMed ID: 15835923
DOI: 10.1021/bi047606a
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2848
Feng, Xingmin, Chuhjo, Tatsuya, Sugimori, Chiharu, Kotani, Takeharu, Lu, Xuzhang, Takami, Akiyoshi, Takamatsu, Hiroyuki, Yamazaki, Hirohito, Nakao, Shinji
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells.
Blood
2004
104:2425-31
PubMed ID: 15217832
DOI: 10.1182/blood-2004-05-1839
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2665
Iwasaki A, Doi T, Umetani M, Watanabe M, Suda M, Hattori Y, Nagoya T
Affinity improvement of the high-affinity immunoglobulin E receptor by phage display.
Biochem Biophys Res Commun
2002
293:542-8
PubMed ID: 12054635
DOI: 10.1016/S0006-291X(02)00261-9
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5969
Morita M, Yoshiuchi N, Arakawa H, Nishimura S.
CMAP: a novel cystatin-like gene involved in liver metastasis.
Cancer Res
1999
59(1):151-8
PubMed ID: 9892200
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17237
Isoda H, Kitamoto D, Shinmoto H, Matsumura M, Nakahara T.
Microbial extracellular glycolipid induction of differentiation and inhibition of the protein kinase C activity of human promyelocytic leukemia cell line HL60
Biosci Biotechnol Biochem
1997
61(4):609-14
PubMed ID: 9145519
DOI: 10.1271/bbb.61.609
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2119
Yoshinobu Matsuo, Ayumi Okochi, Toshio Ariyasu, Emi Iimura and Tadao Ohno
Identification of Cell Lines with Variabel Numbers of Tandem Repeat(VNTR) Amplified by Polymerase Chain Reaction
Tiss Cult Res Commun
1996
15:211-219
DOI: 10.11418/jtca1981.15.4_21
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