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Cell No. : Cell Name
RCB0483 : LA-N-1  update : 2019/01/18
CommentNeuroblastoma. N-myc gene amplification.
Comment from the depositor
Terms and conditionsNon-profit institutions only.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Nishi, Yoshisuke
Originator Seeger, Robert C.
Year of deposit 1990
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 2 years
Tissue bone marrow
Case history neuroblastoma (stage IV)
Metastastatic ability Yes
Metastatsd tissue bone marrow
Classification cancer
History Latt, S. A.
Lifespan infinite
Morphology other
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin (1min.) or pipetting
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 69-83(50) : /78(3),79(3),80(3),81(13),82(18),83(5)
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lot info
Reference information Reference 8
User's Publication 4

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4701  Chen RL1, Reynolds CP, Seeger RC.  Neutrophils are cytotoxic and growth-inhibiting for neuroblastoma cells with an anti-GD2 antibody but, without cytotoxicity, can be growth-stimulating.  Cancer Immunol Immunother.  2000  48(11):603-12  PubMed ID: 10663607
4700  Uçar K, Seeger RC, Challita PM, Watanabe CT, Yen TL, Morgan JP, Amado R, Chou E, McCallister T, Barber JR, et al.  Sustained cytokine production and immunophenotypic changes in human neuroblastoma cell lines transduced with a human gamma interferon vector.  Cancer Gene Ther  1995  2(3):171-81  PubMed ID: 8528960
1287  Gilbert F, Feder M, Balaban G, Brangman D, Lurie, D K, Podolsky R, Rinaldt V, Vinikoor N, Weisband J  Human neuroblastomas and abnormalities of chromosomes 1 and 17.  Cancer Res  1984  44:5444-9  PubMed ID: 6488196
4697  Sidell N, Altman A, Haussler MR, Seeger RC.  Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines.  Exp Cell Res  1983  148(1):21-30  PubMed ID: 6313408
4695  Danon YL, Epstein MB, Siegel MM, Rucker N, Myers CP, Norman A, Benedict WF, Seeger RC.  Variability in DNA distributions of human neuroblastomas after cyclophosphamide.  Cancer Treat Rep  1980  64(12):1275-81  PubMed ID: 7471116
4696  Siegel MM, Chung HS, Rucker N, Siegel SE, Seeger RC, Isaacs H Jr, Benedict WF.  In vitro and in vivo preclinical chemotherapy studies of human neuroblastoma.  Cancer Treat Rep  1980  64(8-9):975-9  PubMed ID: 7448832
1122  Seeger, R C, Rayner, S A, Banerjee A, Chung H, Laug, W E, Neustein, H B, Benedict, W F  Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.  Cancer Res  1977  37:1364-71  PubMed ID: 856461
4694  West GJ, Uki J, Herschman HR, Seeger RC.  Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.  Cancer Res  1977  37(5):1372-6  PubMed ID: 15722

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User's Publication
10728  Kurita M, Takada T, Wakabayashi N, Asami S, Ono S, Uchiyama T, Suzuki T.  Antitumor Effect of Burchellin Derivatives Against Neuroblastoma.  Anticancer Res.  2018  38:855-862  PubMed ID: 29374712
7941  Hayama T, Tabata K, Uchiyama T, Fujimoto Y, Suzuki T.  Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma.  J Nat Med  2011  65:431-9  PubMed ID: 21327520
9486  F H Lo, N K Mak, K N Leung  Studies on the Anti-Tumor Activities of the Soy Isoflavone Daidzein on Murine Neuroblastoma Cells  Biomed Pharmacother  2007  61(9):591-5  PubMed ID: 17905565
1969  Maruyama K, Tsukada T, Bandoh S, Sasaki K, Ohkura N, Yamaguchi K  Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines.  Cancer Lett  1995  96:117-22  PubMed ID: 7553599

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