細胞番号 : 細胞名
RCB0470 : Lu-140
update : 2024/01/17
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| 細胞特性(Comment:英) | Small cell carcimoma, classic type. Application consideration |
| 細胞特性(日) | 日本人肺小細胞癌。Dense cored granuleを殆ど認めない。培養開始にあたっての注意 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Terasaki, Takeo
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| 樹立者 |
Terasaki, T. & Shimosato, Y.
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| 寄託日 |
1990
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| 動物種 |
_human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 人種 |
Japanese
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| 性別 |
Male
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| 齢 |
53 years
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| 採取組織 |
lung
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| 病名 |
small cell carcinoma
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| 細胞分類 |
cancer
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| 初代培養日 |
1985
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|
細胞寿命 |
infinite
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| 細胞形態 |
other
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| Cellosaurus(Expasy) |
CVCL_3335
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Suspension cells
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| 培養方法 |
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浮遊細胞の培養に関する一般的な注意(Japanese)
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| 培地 |
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RPMI1640 + 10% FBS
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| 抗生物質 |
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Free
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|
継代方法 |
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dilution
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|
継代密度 |
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1 : 2 split
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| 継代・培地交換頻度 |
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Subculture : once/week, Medium Renewal : 2 times/week
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| 培養最適温度 |
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37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ/アコレプラズマ |
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(-)
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| ウィルス（HIV) |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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67-139(50) : /69(6),70(12),71(12),72(12),73(2)/
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| 個体識別検査 |
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OK
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| 文献情報 |
Reference(英) |
9件
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| Reference(日) |
1件
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| 利用者成果(英) |
9件
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| 利用者成果(日) |
0件
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| Reference(英) |
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870
Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers
Am J Pathol
2002
161(1):207-16
PubMed ID: 12107105
DOI: 10.1016/S0002-9440(10)64172-7
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3149
Gemma A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M
Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.
Lung Cancer
2001
32:289-95
PubMed ID: 11390010
DOI: 10.1016/s0169-5002(00)00223-3
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3150
Tanaka K, Terasaki T
Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines
Oncogene
1997
88:176-183
PubMed ID: 9119746
DOI: 10.1111/j.1349-7006.1997.tb00363.x
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3148
Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare, E A, McMemamin, M G, Hussain, S P, Forrester K, Zariwala M, Xiong Y, Harris, C C
Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.
Int J Cancer
1996
68:605-11
PubMed ID: 8938142
DOI: 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO;2-2
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3144
Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S
Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.
Cancer Res
1995
55:2206-11
PubMed ID: 7743525
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1974
Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K
Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
Jpn J Cancer Res (--> Cancer Sci)
1994
85:718-22
PubMed ID: 8071114
DOI: 10.1111/j.1349-7006.1994.tb02420.x
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1368
Matsumoto T, Terasaki T, Mukai K, Wada M, Okamoto A, Yokota J, Yamaguchi K, Kato K, Nagatsu T, Shimosato Y
Relation between nucleolar size and growth characteristics in small cell lung cancer cell lines.
Jpn J Cancer Res
1991
82:820-8
PubMed ID: 1715338
DOI: 10.1111/j.1349-7006.1991.tb02708.x
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1111
Yokota J, Akiyama T, Fung, Y K, Benedict, W F, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, et al.
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.
Oncogene
1988
3:471-5
PubMed ID: 2856251
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1118
Terasaki T, Shimosato Y, Nakajima T, Tsumuraya M, Morinaga S, Hirohashi S, Yamaguchi K, Kato K, Ichinose H, Nagatsu T
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn J Clin Oncol
1986
16:203-12
PubMed ID: 3022030
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| 利用者成果(英) |
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9502
Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Cancer Cell
2018
33:355-367.e7
PubMed ID: 29533781
DOI: 10.1016/j.ccell.2018.02.004
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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2481
Okudela K, Yazawa T, Woo T, Sakaeda M, Ishii J, Mitsui H, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Takahashi T, Sugimura H, Kitamura H.
Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis.
Am J Pathol
2009
175(2):867-81
PubMed ID: 19608870
DOI: 10.2353/ajpath.2009.080489
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12769
Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H.
Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis
Am J Pathol
2009
175(6):2646-56
PubMed ID: 19893046
DOI: 10.2353/ajpath.2009.080571
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19312
Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H.
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest
Nucleic Acids Res
2006
34(17):4878-92.
PubMed ID: 16973895
DOI: 10.1093/nar/gkl651
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16489
Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S.
Proteomic signatures for histological types of lung cancer
Proteomics
2005
5(11):2939-48
PubMed ID: 15996008
DOI: 10.1002/pmic.200401166
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2929
Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles
Lancet
2004
63:775-781
PubMed ID: 15016488
DOI: 10.1016/S0140-6736(04)15693-6
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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3140
Koh T, Yokota J, Ookawa K, Kina T, Koshimura K, Miwa S, Ariyasu T, Yamada H, Osaka M, Haga H, et al.
Alternative splicing of the neurofibromatosis 1 gene correlates with growth patterns and neuroendocrine properties of human small-cell lung-carcinoma cells.
Int J Cancer
1995
60:843-7
PubMed ID: 7896456
DOI: 10.1002/ijc.2910600620
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