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Cell No. : Cell Name
RCB0469 : Lu-139  update : 2024/01/17
CommentSmall cell carcinoma, classic type. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Terasaki, Takeo
Originator Tsumuraya, M. & Nakajima, T.
Year of deposit 1990
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 63 years
Tissue lung
Disease name small cell carcinoma
Classification cancer
Year of origin 1986
History M. Tsunuraya
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_1390
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Culture method
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 54-138(50) : /65(2),66(44),67(13),68(22),69(1)/
STR(human) OK
Reference information Reference 11
User's Publication 24

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870  Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J.  A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers  Am J Pathol  2002  161(1):207-16  PubMed ID: 12107105   DOI: 10.1016/S0002-9440(10)64172-7
3149  Gemma A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M  Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.  Lung Cancer  2001  32:289-95  PubMed ID: 11390010   DOI: 10.1016/s0169-5002(00)00223-3
3150  Tanaka K, Terasaki T  Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines  Oncogene  1997  88:176-183  PubMed ID: 9119746   DOI: 10.1111/j.1349-7006.1997.tb00363.x
3148  Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare, E A, McMemamin, M G, Hussain, S P, Forrester K, Zariwala M, Xiong Y, Harris, C C  Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.  Int J Cancer  1996  68:605-11  PubMed ID: 8938142   DOI: 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO;2-2
3144  Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S  Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.  Cancer Res  1995  55:2206-11  PubMed ID: 7743525  
1974  Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K  Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.  Jpn J Cancer Res (--> Cancer Sci)  1994  85:718-22  PubMed ID: 8071114   DOI: 10.1111/j.1349-7006.1994.tb02420.x
1368  Matsumoto T, Terasaki T, Mukai K, Wada M, Okamoto A, Yokota J, Yamaguchi K, Kato K, Nagatsu T, Shimosato Y  Relation between nucleolar size and growth characteristics in small cell lung cancer cell lines.  Jpn J Cancer Res   1991  82:820-8  PubMed ID: 1715338   DOI: 10.1111/j.1349-7006.1991.tb02708.x
3142  Nakagawa K, Yokota J, Wada M, Sasaki Y, Fujiwara Y, Sakai M, Muramatsu M, Terasaki T, Tsunokawa Y, Terada M, et al.  Levels of glutathione S transferase pi mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin.  Jpn J Cancer Res  1988  79:301-4  PubMed ID: 2836347   DOI: 10.1111/j.1349-7006.1988.tb01590.x
1112  Yokota J, Wada M, Yoshida T, Noguchi M, Terasaki T, Shimosato Y, Sugimura T, Terada M  Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes.  Oncogene  1988  2:607-11  PubMed ID: 2838790  
1111  Yokota J, Akiyama T, Fung, Y K, Benedict, W F, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, et al.  Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.  Oncogene  1988  3:471-5  PubMed ID: 2856251  
1118  Terasaki T, Shimosato Y, Nakajima T, Tsumuraya M, Morinaga S, Hirohashi S, Yamaguchi K, Kato K, Ichinose H, Nagatsu T  Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.  Jpn J Clin Oncol  1986  16:203-12  PubMed ID: 3022030  

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User's Publication
21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3
20732  Omori M, Noro R, Seike M, Matsuda K, Hirao M, Fukuizumi A, Takano N, Miyanaga A, Gemma A.  Inhibitors of ABCB1 and ABCG2 overcame resistance to topoisomerase inhibitors in small cell lung cancer.  Thorac Cancer  2022    PubMed ID: 35719112   DOI: 10.1111/1759-7714.14527
11373  Mahoney CE, Pirman D, Chubukov V, Sleger T, Hayes S, Fan ZP, Allen EL, Chen Y, Huang L, Liu M, Zhang Y, McDonald G, Narayanaswamy R, Choe S, Chen Y, Gross S, Cianchetta G, Padyana AK, Murray S, Liu W, Marks KM, Murtie J, Dorsch M, Jin S, Nagaraja N, Biller SA, Roddy T, Popovici-Muller J, Smolen GA.  A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.  Nat Commun  2019    PubMed ID: 30626880   DOI: 10.1038/s41467-018-07959-4
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004
11097  Horie M, Miyashita N, Mattsson JSM, Mikami Y, Sandelin M, Brunnstrom H, Micke P, Nagase T, Saito A.  An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer.  J. Pathol.  2018  246(2):154-165  PubMed ID: 29876935   DOI: 10.1002/path.5109
10922  Shigeaki Umeda et al  Loss of IL-24 expression facilitates invasion in lung adenocarcinoma   Int J Clin Exp Pathol  2017  10:173-185   
12942  Horie M, Saito A, Ohshima M, Suzuki HI, Nagase T.  YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer  Cancer Sci  2016  107(12):1755-1766  PubMed ID: 27627196   DOI: 10.1111/cas.13078
7379  Matsumoto M, Seike M, Noro R, Soeno C, Sugano T, Takeuchi S, Miyanaga A, Kitamura K, Kubota K, Gemma A.  Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer.  BMC Cancer  2015  15:241  PubMed ID: 25884680   DOI: 10.1186/s12885-015-1202-4
16604  Okudela K, Katayama A, Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H, Ohashi K.  Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung  PLoS One  2014  9(2):e87193  PubMed ID: 24503901   DOI: 10.1371/journal.pone.0087193
4390  Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.  POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.  Pathol Int  2013  63(3):158-68  PubMed ID: 23530560   DOI: 10.1111/pin.12042
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349   DOI: 10.1002/ijc.24865
18296  Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Katsuko S, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T.  Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma  Cancer Sci  2009  100(2):225-32  PubMed ID: 19068083   DOI: 10.1111/j.1349-7006.2008.01030.x
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
12769  Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H.  Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis  Am J Pathol  2009  175(6):2646-56  PubMed ID: 19893046   DOI: 10.2353/ajpath.2009.080571
13836  Murai Y, Hayashi S, Takahashi H, Tsuneyama K, Takano Y.  Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines  Pathol Res Pract  2005  201(2):109-15  PubMed ID: 15901131   DOI: 10.1016/j.prp.2005.01.002
16489  Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S.  Proteomic signatures for histological types of lung cancer  Proteomics  2005  5(11):2939-48  PubMed ID: 15996008   DOI: 10.1002/pmic.200401166
2929  Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y  Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles  Lancet  2004  63:775-781  PubMed ID: 15016488   DOI: 10.1016/S0140-6736(04)15693-6
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795
13883  Kobayashi H, Takemura Y, Hayashi T, Ujiiye T, Kawase M, Niino Y, Miyachi H, Ohshima T, Hotta T.  Expression level of MDR1 message in peripheral blood leukocytes from healthy adults: a competitive nucleic acid sequence-based amplification assay for its determination  Clin Chem Lab Med  2004  42(10):1098-101  PubMed ID: 15552266   DOI: 10.1515/CCLM.2004.226
2214  Katayama M, Iwamatsu A, Masutani H, Furuke K, Takeda K, Wada H, Masuda T, Ishii K  Expression of neural cell adhesion molecule L1 in human lung cancer cell lines.  Cell Struct Funct  1997  22:511-6  PubMed ID: 9431455   DOI: 10.1247/csf.22.511
3140  Koh T, Yokota J, Ookawa K, Kina T, Koshimura K, Miwa S, Ariyasu T, Yamada H, Osaka M, Haga H, et al.  Alternative splicing of the neurofibromatosis 1 gene correlates with growth patterns and neuroendocrine properties of human small-cell lung-carcinoma cells.  Int J Cancer  1995  60:843-7  PubMed ID: 7896456   DOI: 10.1002/ijc.2910600620
6407  Matsushima Y, Kinoshita Y, Nakata H, Inomoto-Naribayashi Y, Asahara M, Kawanami C, Nakamura A, Ito M, Matsui T, Fujiwara T, et al.  Gastrin receptor gene expression in several human carcinomas.  Jpn J Cancer Res  1994  85(8):819-24  PubMed ID: 7928627   DOI: 10.1111/j.1349-7006.1994.tb02953.x
1627  Takato FUJIWARA1, Teiichi MOTOYAMA1, Noriko ISHIHARA2, Hidenobu WATANABE1  Drug Sensitivity of Small Cell Gastrointestinal Carcinoma  ACTA MEDICA et BIOLOGICA   1994  42: 1-5   
1783  Fujiwara T, Motoyama T, Ishihara N, Watanabe H, Kumanishi T, Kato K, Ichinose H, Nagatsu T  Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.  Int J Cancer  1993  54:965-71  PubMed ID: 8392984   DOI: 10.1002/ijc.2910540617

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