細胞番号 : 細胞名
RCB0468 : Lu-135
update : 2023/05/09
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| 細胞特性(Comment:英) | Small cell carcinoma, variant type. Application consideration |
| 細胞特性(日) | 日本人肺小細胞癌。バリアントタイプである。Dense cored granuleを殆ど認めない。培養開始にあたっての注意 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Terasaki, Takeo
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| 樹立者 |
Terasaki, T. & Shimosato, Y.
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| 寄託日 |
1990
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| 動物種 |
_human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 人種 |
Japanese
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| 性別 |
Male
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| 齢 |
69 years
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| 採取組織 |
lung
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| 病名 |
small cell carcinoma
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| 細胞分類 |
cancer
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| 初代培養日 |
1983
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|
細胞寿命 |
infinite
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| 細胞形態 |
other
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| Cellosaurus(Expasy) |
CVCL_1389
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Adherent/Suspension cells
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| 培地 |
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RPMI1640 + 10% FBS
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| 抗生物質 |
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Free
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継代方法 |
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dilution
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|
継代密度 |
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1 : 5 split
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| 継代・培地交換頻度 |
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Subculture : once/week, Medium Renewal : 2 times/week
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| 培養最適温度 |
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37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ |
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(-)
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| ウィルス（HIV) |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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27-58(50) : /40(3),41(3),42(6),43(3),45(1),46(4)/
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| 個体識別検査 |
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OK
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| 画像情報 |
寄託時情報 | ロット情報 |
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| 文献情報 |
Reference(英) |
13件
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| Reference(日) |
1件
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| 利用者成果(英) |
14件
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| 利用者成果(日) |
0件
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| Reference(英) |
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869
anaka K, Terasaki T.
Immunocytochemical expression of microtubule-associated protein-2 (MAP-2) in small cell lung cancer cell lines with neuronal-like processes
Jpn J Cancer Res
2002
93(6):699-705
PubMed ID: 12079519
DOI: 10.1111/j.1349-7006.2002.tb01309.x
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870
Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers
Am J Pathol
2002
161(1):207-16
PubMed ID: 12107105
DOI: 10.1016/S0002-9440(10)64172-7
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3149
Gemma A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M
Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.
Lung Cancer
2001
32:289-95
PubMed ID: 11390010
DOI: 10.1016/s0169-5002(00)00223-3
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3150
Tanaka K, Terasaki T
Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines
Oncogene
1997
88:176-183
PubMed ID: 9119746
DOI: 10.1111/j.1349-7006.1997.tb00363.x
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3148
Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare, E A, McMemamin, M G, Hussain, S P, Forrester K, Zariwala M, Xiong Y, Harris, C C
Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.
Int J Cancer
1996
68:605-11
PubMed ID: 8938142
DOI: 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO;2-2
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3144
Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S
Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.
Cancer Res
1995
55:2206-11
PubMed ID: 7743525
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1974
Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K
Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
Jpn J Cancer Res (--> Cancer Sci)
1994
85:718-22
PubMed ID: 8071114
DOI: 10.1111/j.1349-7006.1994.tb02420.x
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3141
Ookawa K, Shiseki M, Takahashi R, Yoshida Y, Terada M, Yokota J
Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations.
Oncogene
1993
8:2175-81
PubMed ID: 8393162
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1368
Matsumoto T, Terasaki T, Mukai K, Wada M, Okamoto A, Yokota J, Yamaguchi K, Kato K, Nagatsu T, Shimosato Y
Relation between nucleolar size and growth characteristics in small cell lung cancer cell lines.
Jpn J Cancer Res
1991
82:820-8
PubMed ID: 1715338
DOI: 10.1111/j.1349-7006.1991.tb02708.x
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3142
Nakagawa K, Yokota J, Wada M, Sasaki Y, Fujiwara Y, Sakai M, Muramatsu M, Terasaki T, Tsunokawa Y, Terada M, et al.
Levels of glutathione S transferase pi mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin.
Jpn J Cancer Res
1988
79:301-4
PubMed ID: 2836347
DOI: 10.1111/j.1349-7006.1988.tb01590.x
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1112
Yokota J, Wada M, Yoshida T, Noguchi M, Terasaki T, Shimosato Y, Sugimura T, Terada M
Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes.
Oncogene
1988
2:607-11
PubMed ID: 2838790
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1111
Yokota J, Akiyama T, Fung, Y K, Benedict, W F, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, et al.
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.
Oncogene
1988
3:471-5
PubMed ID: 2856251
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1118
Terasaki T, Shimosato Y, Nakajima T, Tsumuraya M, Morinaga S, Hirohashi S, Yamaguchi K, Kato K, Ichinose H, Nagatsu T
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn J Clin Oncol
1986
16:203-12
PubMed ID: 3022030
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| 利用者成果(英) |
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10922
Shigeaki Umeda et al
Loss of IL-24 expression facilitates invasion in lung adenocarcinoma
Int J Clin Exp Pathol
2017
10:173-185
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15988
Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, Ikehara Y, Narimatsu H.
Glycoproteomics approach for identifying Glycobiomarker candidate molecules for tissue type classification of non-small cell lung carcinoma
J Proteome Res
2014
13(11):4705-16
PubMed ID: 25244057
DOI: 10.1021/pr5006668
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16604
Okudela K, Katayama A, Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H, Ohashi K.
Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung
PLoS One
2014
9(2):e87193
PubMed ID: 24503901
DOI: 10.1371/journal.pone.0087193
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4390
Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.
POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.
Pathol Int
2013
63(3):158-68
PubMed ID: 23530560
DOI: 10.1111/pin.12042
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8174
Takezawa K, Okamoto I, Tsukioka S, Uchida J, Kiniwa M, Fukuoka M, Nakagawa K.
Identification of thymidylate synthase as a potential therapeutic target for lung cancer.
Br. J. Cancer
2010
103:354-61
PubMed ID: 20628382
DOI: 10.1038/sj.bjc.6605793
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18296
Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Katsuko S, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T.
Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma
Cancer Sci
2009
100(2):225-32
PubMed ID: 19068083
DOI: 10.1111/j.1349-7006.2008.01030.x
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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12769
Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H.
Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis
Am J Pathol
2009
175(6):2646-56
PubMed ID: 19893046
DOI: 10.2353/ajpath.2009.080571
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3395
Yonesaka, Kimio, Tamura, Kenji, Kurata, Takayasu, Satoh, Taroh, Ikeda, Masato, Fukuoka, Masahiro, Nakagawa, Kazuhiko
Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin.
Int J Cancer
2006
118:812-20
PubMed ID: 16108013
DOI: 10.1002/ijc.21350
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2929
Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles
Lancet
2004
63:775-781
PubMed ID: 15016488
DOI: 10.1016/S0140-6736(04)15693-6
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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3140
Koh T, Yokota J, Ookawa K, Kina T, Koshimura K, Miwa S, Ariyasu T, Yamada H, Osaka M, Haga H, et al.
Alternative splicing of the neurofibromatosis 1 gene correlates with growth patterns and neuroendocrine properties of human small-cell lung-carcinoma cells.
Int J Cancer
1995
60:843-7
PubMed ID: 7896456
DOI: 10.1002/ijc.2910600620
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6407
Matsushima Y, Kinoshita Y, Nakata H, Inomoto-Naribayashi Y, Asahara M, Kawanami C, Nakamura A, Ito M, Matsui T, Fujiwara T, et al.
Gastrin receptor gene expression in several human carcinomas.
Jpn J Cancer Res
1994
85(8):819-24
PubMed ID: 7928627
DOI: 10.1111/j.1349-7006.1994.tb02953.x
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13657
Ohta S, Honda A, Tokutake Y, Yoshida H, Hanai N.
Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3
Cancer Immunol Immunother
1993
36(4):260-6
PubMed ID: 8439988
DOI: 10.1007/BF01740908
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