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細胞番号 : 細胞名
RCB0466 : Lu-134-A  update : 2021/02/26
細胞特性(Comment:英)Small cell carcinoma, classic type. See Lu-134-B. Application consideration
細胞特性(日)日本人肺小細胞癌。Lu-134-Bと同一患者より、異なる培養条件で樹立された。培養開始にあたっての注意
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Terasaki, Takeo
樹立者 Terasaki, T. & Shimosato, Y.
寄託日 1990
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
80 years
採取組織 lung
病名 small cell carcinoma
細胞分類 cancer
初代培養日 1982
細胞寿命 infinite
細胞形態 other
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Suspension cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 dilution
継代密度 1 : 2 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
ウィルス(HIV) (-)
アイソザイム検査 LD, NP
染色体検査 28-64(50) : /38(4),39(1),40(1),41(2),42(3),43(2)/
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 9件
Reference(日) 2件
利用者成果(英) 17件
利用者成果(日) 0件

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Reference(英)
3149  Gemma A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M  Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.  Lung Cancer  2001  32:289-95  PubMed ID: 11390010
3150  Tanaka K, Terasaki T  Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines  Oncogene  1997  88:176-183  PubMed ID: 9119746
3148  Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare, E A, McMemamin, M G, Hussain, S P, Forrester K, Zariwala M, Xiong Y, Harris, C C  Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.  Int J Cancer  1996  68:605-11  PubMed ID: 8938142
3144  Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S  Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.  Cancer Res  1995  55:2206-11  PubMed ID: 7743525
3145  Sakuma T, Kodama K, Hara T, Eshita Y, Shibata N, Matsumoto M, Seya T, Mori Y  Levels of complement regulatory molecules in lung cancer: disappearance of the D17 epitope of CD55 in small-cell carcinoma.  Jpn J Cancer Res (--> Cancer Sci)  1993  84:753-9  PubMed ID: 7690355
1368  Matsumoto T, Terasaki T, Mukai K, Wada M, Okamoto A, Yokota J, Yamaguchi K, Kato K, Nagatsu T, Shimosato Y  Relation between nucleolar size and growth characteristics in small cell lung cancer cell lines.  Jpn J Cancer Res   1991  82:820-8  PubMed ID: 1715338
1113  Gamou S, Hunts J, Harigai H, Hirohashi S, Shimosato Y, Pastan I, Shimizu N  Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells.  Cancer Res  1987  47:2668-73  PubMed ID: 3032412
1118  Terasaki T, Shimosato Y, Nakajima T, Tsumuraya M, Morinaga S, Hirohashi S, Yamaguchi K, Kato K, Ichinose H, Nagatsu T  Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.  Jpn J Clin Oncol  1986  16:203-12  PubMed ID: 3022030
735  Terasaki T, Kameya T, Nakajima T, Tsumuraya M, Shimosato Y, Kato K, Ichinose H, Nagatsu T, Hasegawa T  Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.  Gann  1984  75:1089-99  PubMed ID: 6098504

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Reference(日)
1241  蒲生忍,清水信義  バイオテクノロジ-素材としての培養細胞 増殖因子  蛋白質 核酸 酵素  1988  33:1236-1237 
1263  寺崎武夫,下里幸雄  バイオテクノロジ-素材としての培養細胞 人癌細胞(I)  蛋白質 核酸 酵素  1988  33:2606-2608 

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利用者成果(英)
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
11097  Horie M, Miyashita N, Mattsson JSM, Mikami Y, Sandelin M, Brunnstrom H, Micke P, Nagase T, Saito A.  An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer.  J. Pathol.  2018  246(2):154-165  PubMed ID: 29876935
12940  Ohta T, Mita M, Hishinuma S, Ishii-Nozawa R, Takahashi K, Shoji M.  Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165  Front Endocrinol (Lausanne)  2017  8:94  PubMed ID: 28503166
12942  Horie M, Saito A, Ohshima M, Suzuki HI, Nagase T.  YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer  Cancer Sci  2016  107(12):1755-1766  PubMed ID: 27627196
4390  Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.  POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.  Pathol Int  2013  63(3):158-68  PubMed ID: 23530560
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
2481  Okudela K, Yazawa T, Woo T, Sakaeda M, Ishii J, Mitsui H, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Takahashi T, Sugimura H, Kitamura H.  Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis.  Am J Pathol  2009  175(2):867-81  PubMed ID: 19608870
12769  Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H.  Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis  Am J Pathol  2009  175(6):2646-56  PubMed ID: 19893046
3335  Yoshino K, Iimura E, Saijo K, Iwase S, Fukami K, Ohno T, Obata Y, Nakamura Y.  Essential role for gene profiling analysis in the authentication of human cell lines.  Hum Cell  2006  19(1):43-8  PubMed ID: 16643607
3409  Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.  Genes Chromosomes Cancer  2005  44:405-14  PubMed ID: 16114034
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
3094  Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu  Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res  2004  64:6410-5  PubMed ID: 15374948
2758  Harada, Hideki, Saijo, Kaoru, Watanabe, Satoru, Tsuboi, Koji, Nose, Tadao, Ishiwata, Isamu, Ohno, Tadao  Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT.  Jpn J Cancer Res  2002  93:313-9  PubMed ID: 11927014
2429  Fujita M, Fujita T, Kodama T, Tsuchida T, Higashino K  The inhibitory effect of cisplatin in combination with irradiation on lung tumor cell growth is due to induction of tumor cell apoptosis.  Int J Oncol  2000  17:393-7  PubMed ID: 10891552
2372  Fujita M, Tsuchida T, Fujita T, Higashino K  Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.  Oncol Rep  1999  6:353-7  PubMed ID: 10023004
2373  Fujita M, Tsuchida T, Higashino K  Effect of vesnarinone in combination with anti-cancer drugs on lung cancer cell lines.  Anticancer Drugs  1999  10:119-27  PubMed ID: 10194555
6407  Matsushima Y, Kinoshita Y, Nakata H, Inomoto-Naribayashi Y, Asahara M, Kawanami C, Nakamura A, Ito M, Matsui T, Fujiwara T, et al.  Gastrin receptor gene expression in several human carcinomas.  Jpn J Cancer Res  1994  85(8):819-24  PubMed ID: 7928627

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