Cell No. : Cell Name RCB0466 : Lu-134-A  update : 2024/01/17
Comment			Small cell carcinoma, classic type. See Lu-134-B. Application consideration
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Terasaki, Takeo
		Originator	Terasaki, T. & Shimosato, Y.
		Year of deposit	1990
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Race	Japanese
		Gender	Male
		Age at sampling	80 years
		Tissue	lung
		Disease name	small cell carcinoma
		Classification	cancer
		Year of origin	1982
		Lifespan	infinite
		Morphology	other
		Cellosaurus(Expasy)	CVCL_1387
			deposit info	lot info
		Medium	Medium List
		Culture type		Suspension cells
		Culture method		General Guidelines for Culturing Suspension Cells, 浮遊細胞の培養に関する一般的な注意(Japanese)
		Culture medium		RPMI1640 + 10% FBS
		Antibiotics		Free
		Passage method		dilution
	Culture information	Passage ratio		1 : 2 split
		SC frequency		Subculture : once/week, Medium Renewal : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma/Acholeplasma		(-)
		Virus (HIV)		(-)
		Isozyme		LD, NP
		Chromosome mode		28-64(50) : /38(4),39(1),40(1),41(2),42(3),43(2)/
		STR(human)		OK
Images			deposit info	lot info
Reference information		Reference	12
		User's Publication	25

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Reference

869  anaka K, Terasaki T.  Immunocytochemical expression of microtubule-associated protein-2 (MAP-2) in small cell lung cancer cell lines with neuronal-like processes  Jpn J Cancer Res  2002  93(6):699-705  PubMed ID: 12079519   DOI: 10.1111/j.1349-7006.2002.tb01309.x

870  Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J.  A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers  Am J Pathol  2002  161(1):207-16  PubMed ID: 12107105   DOI: 10.1016/S0002-9440(10)64172-7

3149  Gemma A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M  Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.  Lung Cancer  2001  32:289-95  PubMed ID: 11390010   DOI: 10.1016/s0169-5002(00)00223-3

3150  Tanaka K, Terasaki T  Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines  Oncogene  1997  88:176-183  PubMed ID: 9119746   DOI: 10.1111/j.1349-7006.1997.tb00363.x

3148  Gemma A, Takenoshita S, Hagiwara K, Okamoto A, Spillare, E A, McMemamin, M G, Hussain, S P, Forrester K, Zariwala M, Xiong Y, Harris, C C  Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.  Int J Cancer  1996  68:605-11  PubMed ID: 8938142   DOI: 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO;2-2

3144  Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S  Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.  Cancer Res  1995  55:2206-11  PubMed ID: 7743525

1974  Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K  Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.  Jpn J Cancer Res (--> Cancer Sci)  1994  85:718-22  PubMed ID: 8071114   DOI: 10.1111/j.1349-7006.1994.tb02420.x

3145  Sakuma T, Kodama K, Hara T, Eshita Y, Shibata N, Matsumoto M, Seya T, Mori Y  Levels of complement regulatory molecules in lung cancer: disappearance of the D17 epitope of CD55 in small-cell carcinoma.  Jpn J Cancer Res (--> Cancer Sci)  1993  84:753-9  PubMed ID: 7690355   DOI: 10.1111/j.1349-7006.1993.tb02040.x

1368  Matsumoto T, Terasaki T, Mukai K, Wada M, Okamoto A, Yokota J, Yamaguchi K, Kato K, Nagatsu T, Shimosato Y  Relation between nucleolar size and growth characteristics in small cell lung cancer cell lines.  Jpn J Cancer Res   1991  82:820-8  PubMed ID: 1715338   DOI: 10.1111/j.1349-7006.1991.tb02708.x

1113  Gamou S, Hunts J, Harigai H, Hirohashi S, Shimosato Y, Pastan I, Shimizu N  Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells.  Cancer Res  1987  47:2668-73  PubMed ID: 3032412

1118  Terasaki T, Shimosato Y, Nakajima T, Tsumuraya M, Morinaga S, Hirohashi S, Yamaguchi K, Kato K, Ichinose H, Nagatsu T  Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.  Jpn J Clin Oncol  1986  16:203-12  PubMed ID: 3022030

735  Terasaki T, Kameya T, Nakajima T, Tsumuraya M, Shimosato Y, Kato K, Ichinose H, Nagatsu T, Hasegawa T  Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.  Gann  1984  75:1089-99  PubMed ID: 6098504

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User's Publication

22524  Kasai F, Fukushima M, Miyagi Y, Nakamura Y.  Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan  Hum Cell  2024  37(4):944-950  PubMed ID: 38639832   DOI: 10.1007/s13577-024-01055-0

21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3

9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004

11097  Horie M, Miyashita N, Mattsson JSM, Mikami Y, Sandelin M, Brunnstrom H, Micke P, Nagase T, Saito A.  An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer.  J. Pathol.  2018  246(2):154-165  PubMed ID: 29876935   DOI: 10.1002/path.5109

12940  Ohta T, Mita M, Hishinuma S, Ishii-Nozawa R, Takahashi K, Shoji M.  Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165  Front Endocrinol (Lausanne)  2017  8:94  PubMed ID: 28503166   DOI: 10.3389/fendo.2017.00094

12942  Horie M, Saito A, Ohshima M, Suzuki HI, Nagase T.  YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer  Cancer Sci  2016  107(12):1755-1766  PubMed ID: 27627196   DOI: 10.1111/cas.13078

18292  Walls M, Baxi SM, Mehta PP, Liu KK, Zhu J, Estrella H, Li C, Zientek M, Zong Q, Smeal T, Yin MJ.  Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216  Clin Cancer Res  2014  20(3):631-43  PubMed ID: 24240111   DOI: 10.1158/1078-0432.CCR-13-1663

19328  Ono H, Motoi N, Nagano H, Miyauchi E, Ushijima M, Matsuura M, Okumura S, Nishio M, Hirose T, Inase N, Ishikawa Y.  Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer  Cancer Med  2014  3(3):632-42  PubMed ID: 24591352   DOI: 10.1002/cam4.220

15988  Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, Ikehara Y, Narimatsu H.  Glycoproteomics approach for identifying Glycobiomarker candidate molecules for tissue type classification of non-small cell lung carcinoma  J Proteome Res   2014  13(11):4705-16  PubMed ID: 25244057   DOI: 10.1021/pr5006668

4390  Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.  POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.  Pathol Int  2013  63(3):158-68  PubMed ID: 23530560   DOI: 10.1111/pin.12042

19029  Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y.  LRRN4 and UPK3B are markers of primary mesothelial cells  PLoS One  2011  6(10):e25391  PubMed ID: 21984916   DOI: 10.1371/journal.pone.0025391

6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x

2481  Okudela K, Yazawa T, Woo T, Sakaeda M, Ishii J, Mitsui H, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Takahashi T, Sugimura H, Kitamura H.  Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis.  Am J Pathol  2009  175(2):867-81  PubMed ID: 19608870   DOI: 10.2353/ajpath.2009.080489

12769  Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, Ogawa N, Masuda M, Sugimura H, Kitamura H.  Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis  Am J Pathol  2009  175(6):2646-56  PubMed ID: 19893046   DOI: 10.2353/ajpath.2009.080571

19312  Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H.  Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest  Nucleic Acids Res  2006  34(17):4878-92.  PubMed ID: 16973895   DOI: 10.1093/nar/gkl651

3335  Yoshino K, Iimura E, Saijo K, Iwase S, Fukami K, Ohno T, Obata Y, Nakamura Y.  Essential role for gene profiling analysis in the authentication of human cell lines.  Hum Cell  2006  19(1):43-8  PubMed ID: 16643607   DOI: 10.1111/j.1749-0774.2005.00007.x

3409  Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.  Genes Chromosomes Cancer  2005  44:405-14  PubMed ID: 16114034   DOI: 10.1002/gcc.20253

3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795

3094  Kaneda, Atsushi, Wakazono, Kuniko, Tsukamoto, Tetsuya, Watanabe, Naoko, Yagi, Yukiko, Tatematsu, Masae, Kaminishi, Michio, Sugimura, Takashi, Ushijima, Toshikazu  Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.  Cancer Res  2004  64:6410-5  PubMed ID: 15374948   DOI: 10.1158/0008-5472.CAN-04-1543

16648  Konishi J, Yamazaki K, Yokouchi H, Shinagawa N, Iwabuchi K, Nishimura M.  The characteristics of human NKT cells in lung cancer--CD1d independent cytotoxicity against lung cancer cells by NKT cells and decreased human NKT cell response in lung cancer patients  Hum Immunol  2004  65(11):1377-88  PubMed ID: 15556688   DOI: 10.1016/j.humimm.2004.09.003

2758  Harada, Hideki, Saijo, Kaoru, Watanabe, Satoru, Tsuboi, Koji, Nose, Tadao, Ishiwata, Isamu, Ohno, Tadao  Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT.  Jpn J Cancer Res  2002  93:313-9  PubMed ID: 11927014   DOI: 10.1111/j.1349-7006.2002.tb02174.x

2429  Fujita M, Fujita T, Kodama T, Tsuchida T, Higashino K  The inhibitory effect of cisplatin in combination with irradiation on lung tumor cell growth is due to induction of tumor cell apoptosis.  Int J Oncol  2000  17:393-7  PubMed ID: 10891552   DOI: 10.3892/ijo.17.2.393

2372  Fujita M, Tsuchida T, Fujita T, Higashino K  Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.  Oncol Rep  1999  6:353-7  PubMed ID: 10023004   DOI: 10.3892/or.6.2.353

2373  Fujita M, Tsuchida T, Higashino K  Effect of vesnarinone in combination with anti-cancer drugs on lung cancer cell lines.  Anticancer Drugs  1999  10:119-27  PubMed ID: 10194555   DOI: 10.1097/00001813-199901000-00015

6407  Matsushima Y, Kinoshita Y, Nakata H, Inomoto-Naribayashi Y, Asahara M, Kawanami C, Nakamura A, Ito M, Matsui T, Fujiwara T, et al.  Gastrin receptor gene expression in several human carcinomas.  Jpn J Cancer Res  1994  85(8):819-24  PubMed ID: 7928627   DOI: 10.1111/j.1349-7006.1994.tb02953.x