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細胞番号 : 細胞名
RCB0444 : RERF-LC-AI  update : 2021/02/26
細胞特性(Comment:英)Japanese lung squamous carcinoma.
細胞特性(日)肺扁平上皮癌の典型例として利用される。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Akiyama, Mitoshi
樹立者 Akiyama, Mitoshi
寄託日 1989
別名 AOI
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
採取組織 lung
病名 squamous carcinoma
細胞分類 cancer
初代培養日 1983
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
ウィルス(HIV) (-)
アイソザイム検査 LD, NP
染色体検査 45-102(50) : /47(2),48(11),49(9),50(12),51(6),52(2)/
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 1件
Reference(日) 0件
利用者成果(英) 33件
利用者成果(日) 1件

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Reference(英)
1152  Kyoizumi S, Akiyama M, Kouno N, Kobuke K, Hakoda M, Jones, S L, Yamakido M  Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.  Cancer Res  1985  45:3274-81  PubMed ID: 4005855

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Reference(日)

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利用者成果(英)
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667
12073  Haruna M, Hirata M, Iwahori K, Kanazawa T, Yamamoto Y, Goto K, Kawashima A, Morimoto-Okazawa A, Funaki S, Shintani Y, Kumanogoh A, Wada H.  Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer.  Biol. Pharm. Bull.  2020    PubMed ID: 32115500
13246  Bilguun EO, Kaira K, Kawabata-Iwakawa R, Rokudai S, Shimizu K, Yokobori T, Oyama T, Shirabe K, Nishiyama M.  Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine.  BMC Cancer  2020    PubMed ID: 32993587
13773  Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H, Yamamoto M.  Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites  Cancer Sci  2020  111(2):667-678  PubMed ID: 31828882
11379  Omoto K, Matsuda R, Nakai Y, Tatsumi Y, Nakazawa T, Tanaka Y, Shida Y, Murakami T, Nishimura F, Nakagawa I, Motoyama Y, Nakamura M, Fujimoto K, Hiroyuki N.  Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.  Photodiagnosis Photodyn Ther  2019    PubMed ID: 30639584
11496  Miyake N, Chikumi H, Yamaguchi K, Takata M, Takata M, Okada K, Kitaura T, Nakamoto M, Yamasaki A.  Effect of Cetuximab and EGFR Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type EGFR and Use of KRAS as a Possible Biomarker for Treatment Responsiveness.  Yonago Acta Med  2019    PubMed ID: 30962749
11816  Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A.  Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.  Sci Rep  2019    PubMed ID: 31551535
10748  Matsumoto T, Nagashio R, Ryuge S, Igawa S, Kobayashi M, Fukuda E, Goshima N, Ichinoe M, Jiang SX, Satoh Y, Masuda N, Murakumo Y, Saegusa M, Sato Y.  Basigin expression as a prognostic indicator in stage I pulmonary adenocarcinoma.  Pathol. Int.  2018  68:232-240  PubMed ID: 29431238
10842  Yanagita K, Nagashio R, Jiang SX, Kuchitsu Y, Hachimura K, Ichinoe M, Igawa S, Fukuda E, Goshima N, Satoh Y, Murakumo Y, Saegusa M, Sato Y.  Cytoskeleton-Associated Protein 4 Is a Novel Serodiagnostic Marker for Lung Cancer.  Am. J. Pathol.  2018  188:1328-1333  PubMed ID: 29751934
11149  Shimizu K, Okita R, Saisho S, Maeda AI, Nojima Y, Nakata M.  Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer.  Anticancer Res.  2018  38(8):4637-4644  PubMed ID: 30061230
7006  Iida K, Sakai R, Yokoyama S, Kobayashi N, Togo S, Yoshikawa HY, Rawangkan A, Namiki K, Suganuma M.  Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL.  Sci Rep  2017  7:17770  PubMed ID: 29259259
9953  Akizuki R, Shimobaba S, Matsunaga T, Endo S, Ikari A.  Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma.  Biochim. Biophys. Acta  2017  1864:293-302  PubMed ID: 27884700
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807
9887  Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.  Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.  Anticancer Res.  2016  36:6021-6029  PubMed ID: 27793929
12612  Yonesaka K, Hirotani K, Kawakami H, Takeda M, Kaneda H, Sakai K, Okamoto I, Nishio K, Jänne PA, Nakagawa K.  Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib  Oncogene  2016  35(7):878-86  PubMed ID: 25961915
13951  Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.  RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer  Mol Cancer Res  2013  11(8):937-51  PubMed ID: 23686708
9094  Yumiko Shimura, Junya Suzuki, Miho Muraoka, Maria Carmelita Zulueta Kasuya, Koji Matsuoka, Kenichi Hatanaka  Large Scale Biosynthesis of Ganglioside Analogues by RERF-LC-AI Cells Cultured in HYPERFlask  Prep Biochem Biotechnol  2012  42 (4), 378-92  PubMed ID: 22708814
12718  Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.  Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells  Biochim Biophys Acta  2012  1823(6):1110-8  PubMed ID: 22546605
13664  Ohgidani M, Ichihara H, Goto K, Matsumoto Y, Ueoka R.  Anticancer effects of residual powder from Barley-Shochu distillation remnants against the orthotopic xenograft mouse models of hepatocellular carcinoma in vivo  Biol Pharm Bull  2012  35(6):984-7  PubMed ID: 22687544
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
5888  Kuwabara Y, Yamada T, Yamazaki K, Du WL, Banno K, Aoki D, Sakamoto M.  Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis.  Cancer Sci  2008  99(10):1933-9  PubMed ID: 19016752
6291  Asaka-Amano Y, Takiguchi Y, Yatomi M, Kurosu K, Kasahara Y, Tanabe N, Tatsumi K, Kuriyama T.  Effect of treatment schedule on the interaction of Cisplatin and radiation in human lung cancer cells.  Radiat Res  2007  167(6):637-44  PubMed ID: 17523845
3335  Yoshino K, Iimura E, Saijo K, Iwase S, Fukami K, Ohno T, Obata Y, Nakamura Y.  Essential role for gene profiling analysis in the authentication of human cell lines.  Hum Cell  2006  19(1):43-8  PubMed ID: 16643607
3061  Nagai, Yoshiaki, Miyazawa, Hitoshi, Tanaka, Tomoaki, Udagawa, Kiyoshi, Kato, Motoyasu, Fukuyama, Shunichiro, Yokote, Akemi, Kobayashi, Kunihiko, Kanazawa, Minoru, Hagiwara, Koichi, Hagiwara K  Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.  Cancer Res  2005  65:7276-82  PubMed ID: 16105816
3107  Hashimoto, Kiyoshi, Araki, Kunio, Osaki, Mitsuhiko, Nakamura, Hiroshige, Tomita, Katsuyuki, Shimizu, Eiji, Ito, Hisao  MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications.  Pathobiology  2004  71:193-200  PubMed ID: 15263808
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
13883  Kobayashi H, Takemura Y, Hayashi T, Ujiiye T, Kawase M, Niino Y, Miyachi H, Ohshima T, Hotta T.  Expression level of MDR1 message in peripheral blood leukocytes from healthy adults: a competitive nucleic acid sequence-based amplification assay for its determination  Clin Chem Lab Med  2004  42(10):1098-101  PubMed ID: 15552266
5955  Fujiwara H, Kikkawa Y, Sanzen N, Sekiguchi K.  Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins.  J Biol Chem  2001  276(20):17550-8  PubMed ID: 11278628
2427  Ando S, Nojima K, Ishihara H, Suzuki M, Ando M, Majima H, Ando K, Kuriyama T  Induction by carbon-ion irradiation of the expression of vascular endothelial growth factor in lung carcinoma cells.  Int J Radiat Biol  2000  76:1121-7  PubMed ID: 10947125
9026  H Uchida, N Kiyokawa, T Taguchi, H Horie, J Fujimoto, T Takeda  Shiga Toxins Induce Apoptosis in Pulmonary Epithelium-Derived Cells  Infect Dis  1999  180 (6), 1902-11  PubMed ID: 10558947
6249  Teraoka S1 Kyoizumi S, Suzuki T, Yamakido M, Akiyama M.  Growth suppressive efficacy of human lak cells against human lung-cancer implanted into scid mice.  Int J Oncol  1995  6(6):1271-7  PubMed ID: 21556669

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利用者成果(日)
6252  寺岡 正悟, 秋山 實利, 山木戸 道郎  SCIDマウスに移植されたヒト肺癌に対するヒトLAK細胞の増殖抑制効果  肺癌  1995  35:163-172 



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