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Cell No. : Cell Name
RCB0444 : RERF-LC-AI  update : 2021/05/20
CommentJapanese lung squamous carcinoma.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Akiyama, Mitoshi
Originator Akiyama, Mitoshi
Year of deposit 1989
Another name AOI
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue lung
Disease name squamous carcinoma
Classification cancer
Year of origin 1983
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_4402
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 45-102(50) : /47(2),48(11),49(9),50(12),51(6),52(2)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 50


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Reference
1152  Kyoizumi S, Akiyama M, Kouno N, Kobuke K, Hakoda M, Jones, S L, Yamakido M  Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.  Cancer Res  1985  45:3274-81  PubMed ID: 4005855

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User's Publication
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667
14507  Okita Y, Zheng L, Kawanishi K, Miyoshi H, Yanagihara K, Kato M.  Polyvinyl alcohol scaffolds and supplementation support 3D and sphere culturing of human cancer cell lines by reducing apoptosis and promoting cellular proliferation  Genes Cells  2021  26(5):336-343  PubMed ID: 33638919
14789  Chang A, Liu L, Ashby JM, Wu D, Chen Y, O'Neill SS, Huang S, Wang J, Wang G, Cheng D, Tan X, Petty WJ, Pasche BC, Xiang R, Zhang W, Sun P.  Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer  Cancer Res  2021  81(12):3358-3373  PubMed ID: 33853832
12073  Haruna M, Hirata M, Iwahori K, Kanazawa T, Yamamoto Y, Goto K, Kawashima A, Morimoto-Okazawa A, Funaki S, Shintani Y, Kumanogoh A, Wada H.  Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer.  Biol. Pharm. Bull.  2020    PubMed ID: 32115500
13246  Bilguun EO, Kaira K, Kawabata-Iwakawa R, Rokudai S, Shimizu K, Yokobori T, Oyama T, Shirabe K, Nishiyama M.  Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine.  BMC Cancer  2020    PubMed ID: 32993587
13773  Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H, Yamamoto M.  Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites  Cancer Sci  2020  111(2):667-678  PubMed ID: 31828882
13429  Erkhem-Ochir Bilguunm, Kyoichi Kaira, Reika Kawabata-Iwakawa, Susumu Rokudai, Kimihiro Shimizu, Takehiko Yokobori, Tetsunari Oyama, Ken Shirabe, Masahiko Nishiyama  Syntaxin binding protein 4 as a novel therapeutic target and an effective biomarker for better treatment selection in lung squamous cell carcinoma: A theranostic study  BMC Cancer  2020   
14834  Saito R, Miki Y, Abe T, Miyauchi E, Abe J, Nanamiya R, Inoue C, Sato I, Sasano H.  11β hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma  Br J Cancer  2020  123(1):61-71  PubMed ID: 32336752
11379  Omoto K, Matsuda R, Nakai Y, Tatsumi Y, Nakazawa T, Tanaka Y, Shida Y, Murakami T, Nishimura F, Nakagawa I, Motoyama Y, Nakamura M, Fujimoto K, Hiroyuki N.  Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.  Photodiagnosis Photodyn Ther  2019    PubMed ID: 30639584
11496  Miyake N, Chikumi H, Yamaguchi K, Takata M, Takata M, Okada K, Kitaura T, Nakamoto M, Yamasaki A.  Effect of Cetuximab and EGFR Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type EGFR and Use of KRAS as a Possible Biomarker for Treatment Responsiveness.  Yonago Acta Med  2019    PubMed ID: 30962749
11816  Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A.  Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.  Sci Rep  2019    PubMed ID: 31551535
14814  Hamanaka N, Nakanishi Y, Mizuno T, Horiguchi-Takei K, Akiyama N, Tanimura H, Hasegawa M, Satoh Y, Tachibana Y, Fujii T, Sakata K, Ogasawara K, Ebiike H, Koyano H, Sato H, Ishii N, Mio T.  YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification  Cancer Res  2019  79(22):5734-5745  PubMed ID: 31391186
10748  Matsumoto T, Nagashio R, Ryuge S, Igawa S, Kobayashi M, Fukuda E, Goshima N, Ichinoe M, Jiang SX, Satoh Y, Masuda N, Murakumo Y, Saegusa M, Sato Y.  Basigin expression as a prognostic indicator in stage I pulmonary adenocarcinoma.  Pathol. Int.  2018  68:232-240  PubMed ID: 29431238
10842  Yanagita K, Nagashio R, Jiang SX, Kuchitsu Y, Hachimura K, Ichinoe M, Igawa S, Fukuda E, Goshima N, Satoh Y, Murakumo Y, Saegusa M, Sato Y.  Cytoskeleton-Associated Protein 4 Is a Novel Serodiagnostic Marker for Lung Cancer.  Am. J. Pathol.  2018  188:1328-1333  PubMed ID: 29751934
11149  Shimizu K, Okita R, Saisho S, Maeda AI, Nojima Y, Nakata M.  Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer.  Anticancer Res.  2018  38(8):4637-4644  PubMed ID: 30061230
14822  Hayashi T, Desmeules P, Smith RS, Drilon A, Somwar R, Ladanyi M.  RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition  Clin Cancer Res  2018  24(6):1436-1447  PubMed ID: 29127119
7006  Iida K, Sakai R, Yokoyama S, Kobayashi N, Togo S, Yoshikawa HY, Rawangkan A, Namiki K, Suganuma M.  Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL.  Sci Rep  2017  7:17770  PubMed ID: 29259259
9953  Akizuki R, Shimobaba S, Matsunaga T, Endo S, Ikari A.  Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma.  Biochim. Biophys. Acta  2017  1864:293-302  PubMed ID: 27884700
14238  Ozono K, Ohishi Y, Onishi H, Nakamura K, Motoshita J, Kato M, Nakanishi R, Nakamura M, Oda Y.  Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma  Lab Invest  2017  97(11):1332-1342  PubMed ID: 28604655
14683  Ono C, Fukuhara T, Motooka D, Nakamura S, Okuzaki D, Yamamoto S, Tamura T, Mori H, Sato A, Uemura K, Fauzyah Y, Kurihara T, Suda T, Nishio A, Hmwe SS, Okamoto T, Tatsumi T, Takehara T, Chayama K, Wakita T, Koike K, Matsuura Y.  Characterization of miR-122-independent propagation of HCV  PLoS Pathog  2017  13(5):e1006374  PubMed ID: 28494029
14717  Kuji S, Watanabe R, Sato Y, Iwata T, Hirashima Y, Takekuma M, Ito I, Abe M, Nagashio R, Omae K, Aoki D, Kameya T.  A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases  Gynecol Oncol  2017  144(2):384-390.  PubMed ID: 27908529
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807
9887  Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.  Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.  Anticancer Res.  2016  36:6021-6029  PubMed ID: 27793929
12612  Yonesaka K, Hirotani K, Kawakami H, Takeda M, Kaneda H, Sakai K, Okamoto I, Nishio K, Jänne PA, Nakagawa K.  Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib  Oncogene  2016  35(7):878-86  PubMed ID: 25961915
14314  Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, Lundqvist A, Kiessling R, Seliger B, Nakata M.  Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells  PLoS One  2015  10(10):e0139809  PubMed ID: 26439264
15182  Saito K, Kobayashi M, Nagashio R, Ryuge S, Katono K, Nakashima H, Tsuchiya B, Jiang SX, Saegusa M, Satoh Y, Masuda N, Sato Y.  S100A16 is a Prognostic Marker for Lung Adenocarcinomas  Asian Pac J Cancer Prev  2015  16(16):7039-44  PubMed ID: 26514487
15436  Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Kojima E, Mitsuoka Y, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Yoshizawa H, Murai H, Nakamura Y.  A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity  Bioorg Med Chem  2015  23(9):2247-60  PubMed ID: 25801152
13951  Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.  RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer  Mol Cancer Res  2013  11(8):937-51  PubMed ID: 23686708
9094  Yumiko Shimura, Junya Suzuki, Miho Muraoka, Maria Carmelita Zulueta Kasuya, Koji Matsuoka, Kenichi Hatanaka  Large Scale Biosynthesis of Ganglioside Analogues by RERF-LC-AI Cells Cultured in HYPERFlask  Prep Biochem Biotechnol  2012  42 (4), 378-92  PubMed ID: 22708814
12718  Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.  Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells  Biochim Biophys Acta  2012  1823(6):1110-8  PubMed ID: 22546605
13664  Ohgidani M, Ichihara H, Goto K, Matsumoto Y, Ueoka R.  Anticancer effects of residual powder from Barley-Shochu distillation remnants against the orthotopic xenograft mouse models of hepatocellular carcinoma in vivo  Biol Pharm Bull  2012  35(6):984-7  PubMed ID: 22687544
14287  Kobayashi M, Matsumoto T, Ryuge S, Yanagita K, Nagashio R, Kawakami Y, Goshima N, Jiang SX, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y.  CAXII Is a sero-diagnostic marker for lung cancer  PLoS One  2012  7(3):e33952  PubMed ID: 22439015
14406  Miyake N, Chikumi H, Takata M, Nakamoto M, Igishi T, Shimizu E.  Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells   Oncol Rep  2012  28(3):848-54  PubMed ID: 22710790
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
5888  Kuwabara Y, Yamada T, Yamazaki K, Du WL, Banno K, Aoki D, Sakamoto M.  Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis.  Cancer Sci  2008  99(10):1933-9  PubMed ID: 19016752
15561  Kouta Funamoto, Yuji Komizu, Hideaki Ichihara, Osamu Tanoue, Koichi Goto, Ryuichi Ueoka  Antitumor and Immunostimulatory Effects of Residual Powder from Barley-Shochu Distillation Remnants  Journal of Health Science  2008  54:287-293 
6291  Asaka-Amano Y, Takiguchi Y, Yatomi M, Kurosu K, Kasahara Y, Tanabe N, Tatsumi K, Kuriyama T.  Effect of treatment schedule on the interaction of Cisplatin and radiation in human lung cancer cells.  Radiat Res  2007  167(6):637-44  PubMed ID: 17523845
3335  Yoshino K, Iimura E, Saijo K, Iwase S, Fukami K, Ohno T, Obata Y, Nakamura Y.  Essential role for gene profiling analysis in the authentication of human cell lines.  Hum Cell  2006  19(1):43-8  PubMed ID: 16643607
3061  Nagai, Yoshiaki, Miyazawa, Hitoshi, Tanaka, Tomoaki, Udagawa, Kiyoshi, Kato, Motoyasu, Fukuyama, Shunichiro, Yokote, Akemi, Kobayashi, Kunihiko, Kanazawa, Minoru, Hagiwara, Koichi, Hagiwara K  Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.  Cancer Res  2005  65:7276-82  PubMed ID: 16105816
3107  Hashimoto, Kiyoshi, Araki, Kunio, Osaki, Mitsuhiko, Nakamura, Hiroshige, Tomita, Katsuyuki, Shimizu, Eiji, Ito, Hisao  MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications.  Pathobiology  2004  71:193-200  PubMed ID: 15263808
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
13883  Kobayashi H, Takemura Y, Hayashi T, Ujiiye T, Kawase M, Niino Y, Miyachi H, Ohshima T, Hotta T.  Expression level of MDR1 message in peripheral blood leukocytes from healthy adults: a competitive nucleic acid sequence-based amplification assay for its determination  Clin Chem Lab Med  2004  42(10):1098-101  PubMed ID: 15552266
5955  Fujiwara H, Kikkawa Y, Sanzen N, Sekiguchi K.  Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins.  J Biol Chem  2001  276(20):17550-8  PubMed ID: 11278628
2427  Ando S, Nojima K, Ishihara H, Suzuki M, Ando M, Majima H, Ando K, Kuriyama T  Induction by carbon-ion irradiation of the expression of vascular endothelial growth factor in lung carcinoma cells.  Int J Radiat Biol  2000  76:1121-7  PubMed ID: 10947125
9026  H Uchida, N Kiyokawa, T Taguchi, H Horie, J Fujimoto, T Takeda  Shiga Toxins Induce Apoptosis in Pulmonary Epithelium-Derived Cells  Infect Dis  1999  180 (6), 1902-11  PubMed ID: 10558947
6249  Teraoka S1 Kyoizumi S, Suzuki T, Yamakido M, Akiyama M.  Growth suppressive efficacy of human lak cells against human lung-cancer implanted into scid mice.  Int J Oncol  1995  6(6):1271-7  PubMed ID: 21556669
15096  Teraoka S, Kyoizumi S, Seyama T, Yamakido M, Akiyama M.  A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue  Jpn J Cancer Res  1995  86(5):419-23  PubMed ID: 7790314
15105  Teraoka S, Kyoizumi S, Seyama T, Yamakido M, Akiyama M.  Scid mice model for the in-vivo study of human oncotherapy - studies on the growth and metastasis of human lung-cancer  Int J Oncol  1994  5(3):501-8  PubMed ID: 21559605



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