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Cell No. : Cell Name
RCB0434 : J774.1  update : 2023/09/04
CommentMacrophage-like cell
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Sakagami, Hiroshi
Originator Peter, Ralph
Year of deposit 1989
Another name J774A.1
Animal _mouse < Mammals
Strain name BALB/c
Gender Female
Tissue ascites
Classification other
History Nagumo, Noboru (Showa Univ.)
Lifespan infinite
Morphology other (macrophage-like)
Cellosaurus(Expasy) CVCL_4770
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 7
User's Publication 71

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1185  Sakagami H, Ikeda M, Konno K  Stimulation of tumor necrosis factor-induced human myelogenous leukemic cell differentiation by high molecular weight PSK subfraction.  Biochem Biophys Res Commun  1989  162:597-603  PubMed ID: 2757633   DOI: 10.1016/0006-291x(89)92352-8
1189  Sakagami H, Ikeda M, Unten S, Takeda K, Murayama J, Hamada A, Kimura K, Komatsu N, Konno K  Antitumor activity of polysaccharide fractions from pine cone extract of Pinus parviflora Sieb. et Zucc.  Anticancer Res  1987  7:1153-9  PubMed ID: 3481681  
1294  Ralph P, Nakoinz I  Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic or macrophage tumor cells in culture.  Cancer Res  1977  37:546-50  PubMed ID: 318922  
716  Ralph P, Nakoinz I  Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: enhancement by PPD and LPS.  J Immunol  1977  119:950-54  PubMed ID: 894031  
1141  Ralph P, Moore, M A, Nilsson K  Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines.  J Exp Med  1976  143:1528-33  PubMed ID: 1083890   DOI: 10.1084/jem.143.6.1528
1176  Ralph P, Prichard J, Cohn M  Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.  J Immunol  1975  114:898-905  PubMed ID: 1089721  
1177  Ralph P, Nakoinz I  Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line.  Nature  1975  257:393-4  PubMed ID: 1101071   DOI: 10.1038/257393a0

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User's Publication
21079  Nakanishi T, Izumi M, Suzuki R, Yamaguchi K, Sugamoto K, Erickson L, Kawahara S.  In vitro characterization of anti-inflammatory activities of 3RS, 7R, 11R-phytanic acid.  J Dairy Res  2023  1-8  PubMed ID: 36815363   DOI: 10.1017/S0022029923000146
21096  Yamada H, Uemura A, Miyasaka R.  8(R)-hydroxy-eicosapentaenoic acid (8R-HEPE) induces transcription of cholesterol efflux receptors via activation of liver X receptor in macrophages.  Biosci Biotechnol Biochem  2023    PubMed ID: 36881721   DOI: 10.1093/bbb/zbad025
21252  Koga A, Thongsiri C, Kudo D, Phuong DND, Iwamoto Y, Fujii W, Nagai-Yoshioka Y, Yamasaki R, Ariyoshi W.  Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles.  Biomedicines  2023  11(5)  PubMed ID: 37238962   DOI: 10.3390/biomedicines11051291
15283  Umezawa A, Maruyama C, Endo Y, Suenaga Y, Shijo Y, Kameyama N, Sato A, Nishitani A, Ayaori M, Waki M, Teramoto T, Ikewaki K.  Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial  J Atheroscler Thromb  2022  29(6):881-893  PubMed ID: 34024872   DOI: 10.5551/jat.62832
20481  Kurane T, Matsunaga T, Ida T, Sawada K, Nishimura A, Fukui M, Umemura M, Nakayama M, Ohara N, Matsumoto S, Akaike T, Matsuzaki G, Takaesu G.  GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.  FASEB J  2022  36(1):e22096  PubMed ID: 34907600   DOI: 10.1096/fj.202101074RR
20764  Takenaka Y, Tanaka R, Kitabatake K, Kuramochi K, Aoki S, Tsukimoto M.  Profiling Differential Effects of 5 Selective Serotonin Reuptake Inhibitors on TLRs-Dependent and -Independent IL-6 Production in Immune Cells Identifies Fluoxetine as Preferred Anti-Inflammatory Drug Candidate.  Front Pharmacol  2022  13:874375  PubMed ID: 35814203   DOI: 10.3389/fphar.2022.874375
20944  Saito H, Tachiura W, Nishimura M, Shimizu M, Sato R, Yamauchi Y.  Hydroxylation site-specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR.  J Biol Chem  2022  102733  PubMed ID: 36423680   DOI: 10.1016/j.jbc.2022.102733
13905  Tobita K, Hoshi F, Ohki T, Watanabe I.  Protein denature extracts of Lactobacillus crispatus KT-11 strain promote interleukin 12p40 production via Toll-like receptor 2 in J774.1 cell culture  J Food Biochem  2021  45(2):e13599.  PubMed ID: 33368417   DOI: 10.1111/jfbc.13599
20183  Tamai R, Mashima I, Kiyoura Y.  Alendronate Augments Lipid A-Induced IL-1α Release via Activation of ASC but Not Caspase-11.  Inflammation  2021    PubMed ID: 34080091   DOI: 10.1007/s10753-021-01489-w
20276  Lohning A, Kidachi Y, Kamiie K, Sasaki K, Ryoyama K, Yamaguchi H.  6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β).  Eur J Med Chem  2021  216:113250  PubMed ID: 33691258   DOI: 10.1016/j.ejmech.2021.113250
20287  Zhang T, Tsutsuki H, Islam W, Ono K, Takeda K, Akaike T, Sawa T.  ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation.  Redox Biol  2021  41:101930  PubMed ID: 33740502   DOI: 10.1016/j.redox.2021.101930
15290  Thongsiri C, Nagai-Yoshioka Y, Yamasaki R, Adachi Y, Usui M, Nakashima K, Nishihara T, Ariyoshi W.  Schizophyllum commune β-glucan: Effect on interleukin-10 expression induced by lipopolysaccharide from periodontopathic bacteria  Carbohydr Polym  2021  253:117285  PubMed ID: 33278951   DOI: 10.1016/j.carbpol.2020.117285
16070  Kamada K, Matsushita T, Yamashita T, Matsumoto T, Iwaguro H, Sobajima S, Kuroda R.  Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells  J Clin Med  2021  10(19):4309  PubMed ID: 34640324   DOI: 10.3390/jcm10194309
11977  Tamai R, Suzuki K, Mashima I, Kiyoura Y.  MPMBP down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB but not AP-1 activation.  Int. Immunopharmacol.  2020    PubMed ID: 31901621   DOI: 10.1016/j.intimp.2019.106085
12981  Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, Komada T, Inoue Y, Mise N, Kasahara T, Takahashi M.  Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.  J Cell Physiol  2020    PubMed ID: 32115713   DOI: 10.1002/jcp.29659
13022  Bracamonte ME, Álvarez AM, Sosa AM, Hoyos CL, Lauthier JJ, Cajal SP, Juarez M, Uncos RE, Sánchez-Valdéz FJ, Acuña L, Diosque P, Basombrío MA, Nasser JR, Hashiguchi Y, Korenaga M, Barroso PA, Marco JD.  High performance of an enzyme linked immunosorbent assay for American tegumentary leishmaniasis diagnosis with Leishmania (Viannia) braziliensis amastigotes membrane crude antigens.  PLoS One  2020    PubMed ID: 32379842   DOI: 10.1371/journal.pone.0232829
13348  Noritake K, Aki T, Isa S, Uemura K.  Pyroptotic cell death by exposure to 1-butanol in H9c2 cardiomyoblastoma cells.  Heliyon  2020    PubMed ID: 33294662   DOI: 10.1016/j.heliyon.2020.e05503
13734  Matsugaki A, Matsumoto S, Nakano T.  A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement  Int J Mol Sci  2020  21(18):6659  PubMed ID: 32932973   DOI: 10.3390/ijms21186659
20124  Tan XW, Kobayashi K, Shen L, Inagaki J, Ide M, Hwang SS, Matsuura E.  Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors.  Heliyon  2020  6(12):e05743  PubMed ID: 33376820   DOI: 10.1016/j.heliyon.2020.e05743
14498  Hirano S, Kanno S.  Relevance of autophagy markers to cytotoxicity of zinc compounds in macrophages  Toxicol In Vitro  2020  65:104816  PubMed ID: 32126253   DOI: 10.1016/j.tiv.2020.104816
12304  Tomo Shimizu, Osamu Miyazaki, Takeo Iwamoto, Tomoyuki Usui, Ryo Sato, Chika Hiraishi, Hiroshi Yoshida  A new method for measuring cholesterol efflux capacity uses stable isotope-labeled, not radioactive-labeled, cholesterol  J Lipid Res  2019  60(11):1959-1967  PubMed ID: 31455616   DOI: 10.1194/jlr.D086884
10747  Tamai R, Kiyoura Y.  Alendronate augments lipid A-induced IL-1β release and Smad3/NLRP3/ASC-dependent cell death.  Life Sci.  2018  198:8-17  PubMed ID: 29438662   DOI: 10.1016/j.lfs.2018.02.014
10832  Kitamura H, Saito N, Fujimoto J, Nakashima KI, Fujikura D.  Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro.  BMC Complement Altern Med  2018  18:138  PubMed ID: 29720160   DOI: 10.1186/s12906-018-2198-5
11239  Yano H, Uchida M, Saito T, Aoki T, Kremenik MJ, Oyanagi E.  Reduction of Real-Time Imaging of M1 Macrophage Chemotaxis toward Damaged Muscle Cells is PI3K-Dependent.  Antioxidants (Basel)  2018    PubMed ID: 30297636   DOI: 10.3390/antiox7100138
9855  Konda N, Saeki N, Nishino S, Ogawa K.  Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature.  Histochem. Cell Biol.  2017  147:317-339  PubMed ID: 27665280   DOI: 10.1007/s00418-016-1494-8
10402  Zhang R, Inagawa H, Takahashi M, Kawanishi H, Kazumura K, Tsuchiya H, Morishita N, Kobayashi Y, Masaki T, Kobara H, Soma GI.  Measurement of the Phagocytic Activity of Human Peripheral Blood Using a Highly Sensitive Fluorometric Detection Device Without Hemolysis.  Anticancer Res.  2017  37:3897-3903  PubMed ID: 28668892   DOI: 10.21873/anticanres.11771
10425  Sangkanjanavanich N, Kawai M, Kakuda T, Takai S.  Rescue of an intracellular avirulent Rhodococcus equi replication defect by the extracellular addition of virulence-associated protein A.  J. Vet. Med. Sci.  2017  79:1323-1326  PubMed ID: 28690290   DOI: 10.1292/jvms.17-0350
10508  Kitamura H, Ishino T, Shimamoto Y, Okabe J, Miyamoto T, Takahashi E, Miyoshi I.  Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells.  Mediators Inflamm.  2017  2017:6909415  PubMed ID: 29138532   DOI: 10.1155/2017/6909415
14248  Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M.  The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction  PLoS One  2017  12(5):e0176676  PubMed ID: 28493895   DOI: 10.1371/journal.pone.0176676
14570  Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages  Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages  Inflammation  2017  40(6):1933-1943  PubMed ID: 28766178   DOI: 10.1007/s10753-017-0634-1
7312  Motoyama K, Sako A, Ibrahim Abu Hashim I, Higashi T, Arima H.  Effects of dendrimer/cyclodextrin conjugates as gene transfer carriers on nitric oxide production from macrophages.  J. Pharm. Pharmacol.  2016  68:598-607  PubMed ID: 26076676   DOI: 10.1111/jphp.12439
9562  Hotta A, Fujita O, Uda A, Yamamoto Y, Sharma N, Tanabayashi K, Yamada A, Morikawa S.  Virulence of representative Japanese Francisella tularensis and immunologic consequences of infection in mice.  Microbiol. Immunol.  2016  60:168-76  PubMed ID: 26853540   DOI: 10.1111/1348-0421.12363
9711  Ando T, Komatsu T, Naiki Y, Takahashi K, Yokochi T, Watanabe D, Koide N.  GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells.  Immunopharmacol Immunotoxicol  2016  38:298-302  PubMed ID: 27251848   DOI: 10.1080/08923973.2016.1192191
9734  Zhang R, Kobayashi Y, Kazumura K, Tsuchiya H, Morishita N, Inagawa H, Soma G.  Development of an Evaluation Device for Phagocytic Activity of New Phagocytes Using Simple and pH-sensitive Particles that Do Not Require Pre-treatment.  Anticancer Res.  2016  36:3613-8  PubMed ID: 27354631  
9739  Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y.  The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.  Sci Rep  2016  6:28845  PubMed ID: 27349785   DOI: 10.1038/srep28845
10875    Immune cell response and subsequent bone formation induced by implantation of octacalcium phosphate in a rat tibia defect  RSC Adv  2016  6, 57475-57484    DOI: 10.1039/C6RA10834B
7231  Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.  The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.  Nat. Immunol.  2015  16:1034-43  PubMed ID: 26322480   DOI: 10.1038/ni.3257
7281  Kitahara N, Morisaka H, Aoki W, Takeda Y, Shibasaki S, Kuroda K, Ueda M.  Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation.  AMB Express  2015  5:127  PubMed ID: 26179440   DOI: 10.1186/s13568-015-0127-2
7503  Ito M, Matsuoka I.  Inhibition of P2Y6 receptor-mediated phospholipase C activation and Ca(2+) signalling by prostaglandin E2 in J774 murine macrophages.  Eur. J. Pharmacol.  2015  749:124-32  PubMed ID: 25614334   DOI: 10.1016/j.ejphar.2014.12.024
5303  Yu Z, Ono C, Aiba S, Kikuchi Y, Sora I, Matsuoka H, Tomita H.  Therapeutic concentration of lithium stimulates complement C3 production in dendritic cells and microglia via GSK-3 inhibition.  Glia  2015  63(2):257-70  PubMed ID: 25179772   DOI: 10.1002/glia.22749
15013  Hideaki Suzuki  Probiotics Aspergillus oryzae and Lactobacillus sakei reduce IgE and increase Th1 cytokines in an ovalbumin-induced murine model of allergy  Int J Anal Bio-Sci  2015  3:90-06   
15429  Ishikawa T, Ayaori M, Uto-Kondo H, Nakajima T, Mutoh M, Ikewaki K.  High-density lipoprotein cholesterol efflux capacity as a relevant predictor of atherosclerotic coronary diseaseHigh-density lipoprotein cholesterol efflux capacity as a relevant predictor of atherosclerotic coronary disease  Atherosclerosis  2015  242(1):318-22  PubMed ID: 26246268   DOI: 10.1016/j.atherosclerosis.2015.06.028
9257  Yoshimitsu Okazaki, Emiko Gotoh  Metal Ion Effects on Different Types of Cell Line, Metal Ion Incorporation Into L929 and MC3T3-E1 Cells, and Activation of Macrophage-Like J774.1 Cells  Mater Sci Eng C Mater Biol Appl  2013  33(4):1993-2001  PubMed ID: 23498224   DOI: 10.1016/j.msec.2013.01.015
16144  Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K.  Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound  Oncol Rep  2011  25(4):905-13  PubMed ID: 21249323   DOI: 10.3892/or.2011.1155
8085  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  In Vivo  2010  24:735-43  PubMed ID: 20952742  
8207  Kaori Yoshino, Kaoru Saijo, Chikako Noro and Yukio Nakamura  Development of a simple method to determine the mouse strain from which cultured cell lines originated  Interdisciplinary Bio Central   2010  2:0014    DOI: 10.4051/ibc.2010.2.4.0014
8813  Kanno S, Furuyama A, Hirano S.  A murine scavenger receptor MARCO recognizes polystyrene nanoparticles.  Toxicol. Sci.  2007  97:398-406  PubMed ID: 17361018   DOI: 10.1093/toxsci/kfm050
6295  Barroso PA, Marco JD, Calvopina M, Kato H, Korenaga M, Hashiguchi Y.  A trial of immunotherapy against Leishmania amazonensis infection in vitro and in vivo with Z-100, a polysaccharide obtained from Mycobacterium tuberculosis, alone or combined with meglumine antimoniate.  J Antimicrob Chemother  2007  59(6):1123-9  PubMed ID: 17439977   DOI: 10.1093/jac/dkm079
8866  Matsumoto M, Benno Y.  Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512.  Biosci. Biotechnol. Biochem.  2006  70:1287-92  PubMed ID: 16794305   DOI: 10.1271/bbb.50464
3345  Moro, Toru, Takatori, Yoshio, Ishihara, Kazuhiko, Konno, Tomohiro, Takigawa, Yorinobu, Matsushita, Tomiharu, Chung, Ung-Il, Nakamura, Kozo, Kawaguchi, Hiroshi  Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis.  Nat Mater  2004  3:829-36  PubMed ID: 15502835   DOI: 10.1038/nmat1233
17311  Banskota AH, Tezuka Y, Nguyen NT, Awale S, Nobukawa T, Kadota S.  DPPH radical scavenging and nitric oxide inhibitory activities of the constituents from the wood of Taxus yunnanensis  Planta Med  2003  69(6):500-5  PubMed ID: 12865966   DOI: 10.1055/s-2003-40641
17313  Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S.  Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity  Chem Pharm Bull (Tokyo)   2003  51(3):268-75  PubMed ID: 12612410   DOI: 10.1248/cpb.51.268
3222  Liu, Qingping, Kobayashi, Kazuko, Furukawa, Jun-ichi, Inagaki, Junko, Sakairi, Nobuo, Iwado, Akimasa, Yasuda, Tatsuji, Koike, Takao, Voelker, Dennis R, Matsuura, Eiji  Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages.  J Lipid Res  2002  43:1486-95  PubMed ID: 12235181   DOI: 10.1194/jlr.m20063-jlr200
6451  Ippoushi K, Itou H, Azuma K, Higashio H.  Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages.  Life Sci  2002  71(4):411-9  PubMed ID: 12044841   DOI: 10.1016/s0024-3205(02)01685-5
12848  Morita H, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.  Cytokine production by the murine macrophage cell line J774.1 after exposure to lactobacilli  Biosci Biotechnol Biochem  2002  66(9):1963-6  PubMed ID: 12400700   DOI: 10.1271/bbb.66.1963
15391  Shuji Kojima, Risa Kurozumi, Maiko Tuchiya  A New Functional Role of 5,6,7,8-tetrahydrobiopterin (BH4) as an Inhibitor of γ-glutamylcysteine Synthetase (γ-GCS) mRNA Expression  pteridines  2002  13:83-88    DOI: 10.1515/pteridines.2002.13.3.83
2473  Tanaka I, Ishihara H  Enhanced expression of the early retrotransposon in C3H mouse-derived myeloid leukemia cells.  Virology  2001  280:107-14  PubMed ID: 11162824   DOI: 10.1006/viro.2000.0732
2956  Shibaki T, Suzutani T, Yoshida I, Ogasawara M, Azuma M  Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type 1.  J Interferon Cytokine Res  2001  21:279-85  PubMed ID: 11429158   DOI: 10.1089/107999001300177466
4871  Feng R, Kabayama A, Uchida K, Hoshino H, Miwa M.  Cell-free entry of human T-cell leukemia virus type 1 to mouse cells.  Jpn J Cancer Res  2001  92(4):410-6  PubMed ID: 11346463   DOI: 10.1111/j.1349-7006.2001.tb01110.x
6165  Kobayashi K, Matsuura E, Liu Q, Furukawa J, Kaihara K, Inagaki J, Atsumi T, Sakairi N, Yasuda T, Voelker DR, Koike T.  A specific ligand for beta(2)-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages.  J Lipid Res  2001  42(5):697-709  PubMed ID: 11352976  
5393  Harada M, Imai J, Okuno S, Suzuki T.  Macrophage-mediated activation of camptothecin analogue T-2513-carboxymethyl dextran conjugate (T-0128): possible cellular mechanism for antitumor activity.  J Control Release  2000  69(3):389-97  PubMed ID: 11102679   DOI: 10.1016/s0168-3659(00)00320-5
2360  Tsutsui T, Kawaguchi H, Fujino A, Sakai A, Kaji H, Nakamura T  Exposure of macrophage-like cells to titanium particles does not affect bone resorption, but inhibits bone formation.  J Orthop Sci  1999  4:32-8  PubMed ID: 9914427   DOI: 10.1007/s007760050071
5325  Shige H, Ishikawa T, Suzukawa M, Nishiwaki M, Yamashita T, Nakajima K, Ito T, Higashi K, Ayaori M, Yonemura A, Nestel P, Nakamura H.  Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages.  Lipids  1998  33(12):1169-75  PubMed ID: 9930402   DOI: 10.1007/s11745-998-0320-9
18025  Murata-Kamiya N, Tsutsui T, Fujino A, Kasai H, Kaji H.  Determination of carcinogenic potential of mineral fibers by 8-hydroxydeoxyguanosine as a marker of oxidative DNA damage in mammalian cells  Int Arch Occup Environ Health  1997  70(5):321-6  PubMed ID: 9352335   DOI: 10.1007/s004200050225
18050  Miyagi K, Kawakami K, Saito A.  Role of reactive nitrogen and oxygen intermediates in gamma interferon-stimulated murine macrophage bactericidal activity against Burkholderia pseudomallei  Infect Immun  1997  65(10):4108-13  PubMed ID: 9317015   DOI: 10.1128/iai.65.10.4108-4113.1997
18067  Kishi Y, Sakita S, Ohta S, Watanabe T, Watanabe R, Ashikaga T, Numano F.  Co-culture of platelets with activated J774.1 cells: effects on platelet aggregation and cyclic nucleotides  Ann N Y Acad Sci  1997  811:525-32  PubMed ID: 9186632   DOI: 10.1111/j.1749-6632.1997.tb52036.x
17219  Xu G, Fujita J, Negayama K, Yuube K, Hojo S, Yamaji Y, Kawanishi K, Takahara J.  Effect of macrolide antibiotics on macrophage functions  Microbiol Immunol  1996  40(7):473-9  PubMed ID: 8865152   DOI: 10.1111/j.1348-0421.1996.tb01097.x
17229  Iizuka H, Watanabe Y, Kojima S.  Effect of 5,6,7,8-tetrahydroneopterin on oxidative modification of low-density lipoprotein, and its uptake in the macrophage-like cell line J774  Jpn J Pharmacol  1996  72(4):375-9  PubMed ID: 9015746   DOI: 10.1254/jjp.72.375
3024  Harada Y, Nagao S, Nakamura M, Okada F, Tanigawa Y  Effect of lipopolysaccharide on thymidine salvage as related to macrophage activation.  Immunology  1995  84:247-53  PubMed ID: 7751001  
13867  Hayakawa T, Yamashita K, Ohuchi E, Shinagawa A.  Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)  J Cell Sci  1994  107 ( Pt 9):2373-9.  PubMed ID: 7844157   DOI: 10.1242/jcs.107.9.2373
17211  Y. Nakashima, T. Shuto, K. Hayashi, T. Hotokebuchi, T. Inadome, T. Hara, Y. Sugioka  Stimulatory Effects of Ceramic Particles on the Production of Bone Resorbing Mediators  Bioceramics  1994  305-309    DOI: 10.1016/b978-0-08-042144-5.50051-0

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