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Cell No. : Cell Name
RCB0284 : Sq-1979  update : 2022/03/09
CommentMetastatic epithelial cell
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Ando, Koichi
Originator Majima, Hideyuki
Year of deposit 1989
Original cell NR-S1
Animal mouse < Mammals
Strain name C3H/He
Tissue cheek
Disease name carcinoma planoepitherial
Classification cancer
History Mycoplasma was decontaminated
Memo_1 Mycoplasma was eliminated with MC-210.
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_6541
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 1
User's Publication 7

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1086  Majima H  [Repair of sublethal damage in cultured cells derived from mouse squamous cell carcinoma following an irradiation of mixed neutrons and x-rays]  Nippon Igaku Hoshasen Gakkai Zasshi  1983  43:1307-17  PubMed ID: 6424091

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User's Publication
17186  Sakuma K, Kii T, Takahashi H, Suzuki S, Yoshikawa K, Ogawa T, Tanaka A.  An In Vivo Study of Local Administration of Low-dose Anti-PD-1 Antibody Using an Oral Cancer Cell Line  Anticancer Res  2022  42(9):4293-4303  PubMed ID: 36039414
20202  Matsunami A, Mizuno-Kamiya M, Kawaki H, Takayama E, Ueno K, Ando M, Morimoto-Ito H, Muramatsu Y, Sumitomo S, Kondoh N.  Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) cells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cells.  J Oral Biosci  2021    PubMed ID: 34153475
11681  Hiroe Morimoto-Ito, Masako Mizuno-Kamiya, Naoki Umemura, Yoshinori Inagaki, Eiji Takayama, Harumi Kawaki, Yasunori Muramatsu, Shinichiro Sumitomo, Nobuo Kondoh  Immunosuppressive Effect of Mesenchymal Stromal Cells is Enhanced by IL-1α from Oral Squamous Cell Carcinoma Cells  The Open Dentistry Journal  2019  13:221-227 
10705  Adachi M, Mizuno-Kamiya M, Takayama E, Kawaki H, Inagaki T, Sumi S, Motohashi M, Muramatsu Y, Sumitomo SI, Shikimori M, Yamazaki Y, Kondoh N.  Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line.  Oncol Lett  2018  15:3350-3356  PubMed ID: 29435078
11047    Suppressive effect of mesenchymal stromal cells on interferon-γ-producing capability of spleen cells was specifically enhanced through humoral mediator(s) from mouse oral squamous cell carcinoma Sq-1979 Cells In Vitro  Cancer Translational Medicine  2018  4, 9-16 
11026    The producing capabilities of Interferon-γ and Interleukin-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice  Cancer Transl Med  2017  3:194–9 
14354  Sumi S, Umemura N, Takayama E, Ohkoshi E, Adachi M, Mizuno-Kamiya M, Inagaki T, Kawaki H, Sumitomo S, Kondoh N.  Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells  Oncol Rep  2017  37(5):2897-2904  PubMed ID: 28405677

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