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Cell No. : Cell Name
RCB0256 : BALL-1  update : 2024/06/17
CommentHuman cell line derived from B cell leukemia.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Maekawa, T. (Ito,F.)
Year of deposit 1988
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Tissue blood
Disease name acute lymphoblastoid leukemia (B cell leukemia)
Classification cancer
Memo_1 Mycoplasma was eliminated with MC-210.
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_1075
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Culture method
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 46-48(50) : 46(4),47(22),48(24)
STR(human) OK
deposit info
lot info
Reference information Reference 6
User's Publication 27

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5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  83(20):7898-902  PubMed ID: 3464004   DOI: 10.1073/pnas.83.20.7898
179  Hiraki S, Miyoshi I, Nakamura K, Ohta T, Watanabe Y, Tsubota T, Tanaka T, Kimura I.  Growth characteristics of human leukemic B-cell, T-cell, and null-cell lines serially transplanted in hamsters  Gan  1979  70(6):791-7  PubMed ID: 317052  
180  Hiraki S, Miyoshi I, Nakamura K, Ohta T, Tsubota T, Uno J, Tanaka T, Kimura I.  Heterotransplantation of human leukemic B-cell, T-cell and null-cell lines in hamsters  Acta Med Okayama  1979  33(1):15-20  PubMed ID: 155978  
621  Miyoshi I, Hiraki S, Tsubota T, Kubonishi I, Matsuda Y, Nakayama T, Kishimoto H, Kimura I, Masuji H.  Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias.  Nature  1977  267(5614):843-4  PubMed ID: 197412   DOI: 10.1038/267843a0
177  Hiraki S, Miyoshi I, Masuji H, Kubonishi I, Matsuda Y.  Establishment of an Epstein-Barr virus-determined nuclear antigen-negative human B-cell line from acute lymphoblastic leukemia  J Natl Cancer Inst  1977  59(1):93-4  PubMed ID: 195075   DOI: 10.1093/jnci/59.1.93

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User's Publication
17199  Sawada M, Goto K, Morimoto-Okazawa A, Haruna M, Yamamoto K, Yamamoto Y, Nakagawa S, Hiramatsu K, Matsuzaki S, Kobayashi E, Kawashima A, Hirata M, Iwahori K, Kimura T, Ueda Y, Kimura T, Wada H.  PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer  Int Immunol  2020  32(6):397-405  PubMed ID: 32009163   DOI: 10.1093/intimm/dxaa010
4165  Miyata S, Wang LY, Kitanaka S.  3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt.  Leuk. Res.  2018    PubMed ID: 29179029   DOI: 10.1016/j.leukres.2017.08.007
10269  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.  Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages  J Clin Exp Hematop  2017  57:15-20  PubMed ID: 28420814   DOI: 10.3960/jslrt.17003
14307  Asano T, Narazaki H, Fujita A.  Genome-wide DNA methylation profiling of CpG islands in a morpholino anthracycline derivative-resistant leukemia cell line: p38 α as a novel candidate for resistance  Pharmacol Res Perspect  2016  5(1):e00285  PubMed ID: 28596837   DOI: 10.1002/prp2.285
7787  Hoshi O, Ushiki T.  Atomic force microscopy imaging of human metaphase chromosomes in liquid.  Methods Mol. Biol.  2011  736:109-15  PubMed ID: 21660724   DOI: 10.1007/978-1-61779-105-5_8
7977  Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M.  Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.  J. Biol. Chem.  2011  286:10702-11  PubMed ID: 21266579   DOI: 10.1074/jbc.M110.185793
8149  Ikeda K, Mizutani T, Hoshi O, Ushiki T, Haga H, Kawabata K.  Intermediate structure between chromatin fibers and chromosome revealed by mechanical stretching and SPM measurement.  Biochem. Biophys. Res. Commun.  2010  400:181-6  PubMed ID: 20719238   DOI: 10.1016/j.bbrc.2010.08.041
5879  Shinjiro Maruyama*, Taiki Akasaka, Koji Yamada and Hirofumi Tachibana  Bioactivity of High-molecular-weight Constituents of Cistanche tubulosa  Pharmacologyonline  2009  1:913-921   
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360   DOI: 10.1093/jb/mvp021
8726  Ushiki T, Shigeno M, Hoshi O.  Techniques for imaging human metaphase chromosomes in liquid conditions by atomic force microscopy.  Nanotechnology  2008  19:384022  PubMed ID: 21832581   DOI: 10.1088/0957-4484/19/38/384022
8756  Ushiki T, Hoshi O.  Atomic force microscopy for imaging human metaphase chromosomes.  Chromosome Res.  2008  16:383-96  PubMed ID: 18461479   DOI: 10.1007/s10577-008-1241-7
18824  Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S.  Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation  Bioorg Med Chem  2008  16(9):5039-49  PubMed ID: 18375133   DOI: 10.1016/j.bmc.2008.03.029
8795  Engelhardt P, Merilainen J, Zhao F, Uchiyama S, Fukui K, Lehto VP.  Whole-mount immunoelectron tomography of chromosomes and cells.  Methods Mol. Biol.  2007  369:387-405  PubMed ID: 17656761   DOI: 10.1007/978-1-59745-294-6_19
6289  Shinjiro MARUYAMA, Koji YAMADA, Hirofumi TACHIBANA  Cistanche salsa extract enhanced IgM production in the human B cell line BALL-1  Journal of Traditional Medicines  2007  24:209-211    DOI: 10.11339/jtm.24.209
15599  Kato N, Tanaka J, Sugita J, Toubai T, Miura Y, Ibata M, Syono Y, Ota S, Kondo T, Asaka M, Imamura M.  Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells  Leukemia  2007  21(10):2103-8  PubMed ID: 17625602   DOI: 10.1038/sj.leu.2404862
2974  Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong H, Chen L, Ogata K  Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia  Clin Cancer Res  2005  15:5708-5717  PubMed ID: 16115907   DOI: 10.1158/1078-0432.CCR-04-2672
8960  Higashi T, Miyakawa S, Uchiyama S, Matsunaga S, Takata H, Fujimoto S, Noda M, Terauchi A, Shimizu T, Oda M, Azuma T, Fukui K.  Generation of monoclonal antibodies against chromosomal antigens that have a high sequence similarity between human and mouse.  J. Biotechnol.  2005  120:262-72  PubMed ID: 16171883   DOI: 10.1016/j.jbiotec.2005.06.036
16563  Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M.  Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells  J Immunol  2005  174(3):1566-73  PubMed ID: 15661917   DOI: 10.4049/jimmunol.174.3.1566
3118  Uchiyama S, Kobayashi S, Takata H, Ishihara T, Sone T, Matsunaga S, Fukui K.  Protein composition of human metaphase chromosomes analyzed by two-dimensional electrophoreses.  Cytogenet Genome Res  2004  107(1-2):49-54  PubMed ID: 15305056   DOI: 10.1159/000079571
2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539   DOI: 10.1248/bpb.25.383
4451  Akutsu M, Furukawa Y, Tsunoda S, Izumi T, Ohmine K, Kano Y.  Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro  Leukemia  2002  16(9):1808-17  PubMed ID: 12200697   DOI: 10.1038/sj.leu.2402573
5423  Tanaka K, Hiramoto T, Fukuda T, Miyagawa K.  A novel human rad54 homologue, Rad54B, associates with Rad51.  J Biol Chem  2000  275(34):26316-21  PubMed ID: 10851248   DOI: 10.1074/jbc.M910306199
15575  Hamaguchi T, Masuda A, Morino T, Osada H.  Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases  Chem Biol  1997  4(4):279-86  PubMed ID: 9195865   DOI: 10.1016/s1074-5521(97)90071-5
17960  Suzuki K, Uchii M, Nozawa R.  Expression of calcitonin receptors on human myeloid leukemia cells  J Biochem   1995  118(2):448-52  PubMed ID: 8543584   DOI: 10.1093/oxfordjournals.jbchem.a124928
17964  Hamaguchi T, Sudo T, Osada H.  RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase  FEBS Lett  1995  372(1):54-8  PubMed ID: 7556642   DOI: 10.1016/0014-5793(95)00953-7
11023  T Nishihara , Y Ohsaki, N Ueda, T Koseki, Y Eto  Induction of apoptosis in B lineage cells by activin A derived from macrophages  J Interferon Cytokine Res  1995  15(6):509-16  PubMed ID: 7553220   DOI: 10.1089/jir.1995.15.509
1620  Sasaki, T., Kawai, K., Saijyo-Kurita, K. and Ohno, T.  Detergent Cytotoxicity:Simplified Assay of Cytolysis by Measuring LDH Activity  Toxicol in Vitro  1992  6:451-457  PubMed ID: 20732144   DOI: 10.1016/0887-2333(92)90052-s

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