CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0224 : ST2]

2436 Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H. B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation Eur J Immunol 1998 18(11):1767-71 PubMed ID: 3264531 DOI: 10.1002/eji.1830181117

8597 P A Welch, P D Burrows, A Namen, S Gillis, M D Cooper Bone Marrow Stromal Cells and interleukin-7 Induce Coordinate Expression of the BP-1/6C3 Antigen and pre-B Cell Growth Int Immunol 1990 2 (8), 697-705 PubMed ID: 2083232 DOI: 10.1093/intimm/2.8.697

2437 Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S. Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules J Exp Med 1990 171(5):1683-95 PubMed ID: 2332734 DOI: 10.1084/jem.171.5.1683

1987 Tominaga A, Mita S, Kikuchi Y, Hitoshi Y, Takatsu K, Nishikawa S, Ogawa M Establishment of IL-5-dependent early B cell lines by long-term bone marrow cultures. Growth Factors 1989 1:135-46 PubMed ID: 2624778 DOI: 10.3109/08977198909029123

2570 Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 1989 170:333-8 PubMed ID: 2787384 DOI: 10.1084/jem.170.1.333

965 Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J 1988 7:1337-43 PubMed ID: 3261687 DOI: 10.1002/j.1460-2075.1988.tb02949.x

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21006 Hatori T, Maeda T, Suzuki A, Takahashi K, Kato Y. SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Mol Med Rep 2023 27(2) PubMed ID: 36633137 DOI: 10.3892/mmr.2023.12937

20500 Negishi T, Mihara N, Chiba T, D'Armiento J, Chada K, Maeda M, Igarashi M, Imai K. High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development. Biochem Biophys Res Commun 2022 590:68-74 PubMed ID: 34973532 DOI: 10.1016/j.bbrc.2021.12.093

20580 Inoue M, Nagai-Yoshioka Y, Yamasaki R, Kawamoto T, Nishihara T, Ariyoshi W. Mechanisms involved in suppression of osteoclast supportive activity by transforming growth factor-β1 via the ubiquitin-proteasome system. PLoS One 2022 17(2):e0262612 PubMed ID: 35196318 DOI: 10.1371/journal.pone.0262612

16338 Gámez B, Morris EV, Olechnowicz SWZ, Webb S, Edwards JR, Sowman A, Turner CJ, Edwards CM. The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo Transl Oncol 2022 15(1):101301 PubMed ID: 34890968 DOI: 10.1016/j.tranon.2021.101301

16515 Sordi MB, Cabral da Cruz AC, Panahipour L, Gruber R. Enamel Matrix Derivative Decreases Pyroptosis-Related Genes in Macrophages Int J Mol Sci 2022 23(9):5078 PubMed ID: 35563469 DOI: 10.3390/ijms23095078

20671 Chen JR, Lazarenko OP, Blackburn ML, Chen JF, Randolph CE, Zabaleta J, Schroder K, Pedersen KB, Ronis MJJ. Nox4 expression in osteo-progenitors controls bone development in mice during early life. Commun Biol 2022 5(1):583 PubMed ID: 35701603 DOI: 10.1038/s42003-022-03544-0

16842 Phillips E, Ahmad N, Sun L, Iben J, Walkey CJ, Rusin A, Yuen T, Rosen CJ, Willis IM, Zaidi M, Johnson DL. MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass Elife 2022 11:e74740 PubMed ID: 35611941 DOI: 10.7554/eLife.74740

20928 Yu F, Li F, Yu P, Zhou B, Ye L. Identification and characterization of NFATc1+ skeletal stem cells in bone regeneration. Cell Rep 2022 41(6):111599 PubMed ID: 36351390 DOI: 10.1016/j.celrep.2022.111599

17334 Panahipour L, Abbasabadi AO, Kaiser V, Sordi MB, Kargarpour Z, Gruber R. Damaged Mesenchymal Cells Dampen the Inflammatory Response of Macrophages and the Formation of Osteoclasts J Clin Med 2022 11(14):4061 PubMed ID: 35887825 DOI: 10.3390/jcm11144061

13190 Parisi L, Buser D, Chappuis V, Asparuhova MB. Cellular responses to deproteinized bovine bone mineral biofunctionalized with bone-conditioned medium. Clin Oral Investig 2021 25(4):2159-2173 PubMed ID: 32870390 DOI: 10.1007/s00784-020-03528-6

13394 Tabuchi Y, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Hirayama J, Hoshi N, Mochizuki T. Genetic response to low‑intensity ultrasound on mouse ST2 bone marrow stromal cells. Mol Med Rep 2021 PubMed ID: 33398373 DOI: 10.3892/mmr.2020.11812

20134 Hariri H, Addison WN, St-Arnaud R. Ubiquitin specific peptidase Usp53 regulates osteoblast versus adipocyte lineage commitment. Sci Rep 2021 11(1):8418 PubMed ID: 33875709 DOI: 10.1038/s41598-021-87608-x

20179 Ito Y, Yamamoto M, Furukawa S, Fukui M, Morishita K, Kitao T, Shirahase H. Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats. Biol Pharm Bull 2021 44(5):659-668 PubMed ID: 33952822 DOI: 10.1248/bpb.b20-01002

14506 Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H. Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells BMC Musculoskelet Disord 2021 22(1):398 PubMed ID: 33910546 DOI: 10.1186/s12891-021-04278-6

14509 Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H. Serpinb1a suppresses osteoclast formation Biochem Biophys Rep 2021 26:101004 PubMed ID: 33997318 DOI: 10.1016/j.bbrep.2021.101004

14783 Yu J, Choi S, Park A, Do J, Nam D, Kim Y, Noh J, Lee KY, Maeng CH, Park KS. Bone Marrow Homeostasis Is Impaired via JAK/STAT and Glucocorticoid Signaling in Cancer Cachexia Model Cancers (Basel) 2021 13(5):1059 PubMed ID: 33801569 DOI: 10.3390/cancers13051059

16332 Lin Z, Nica C, Sculean A, Asparuhova MB. Positive Effects of Three-Dimensional Collagen-Based Matrices on the Behavior of Osteoprogenitors Front Bioeng Biotechnol 2021 9:708830 PubMed ID: 34368101 DOI: 10.3389/fbioe.2021.708830

16417 Kota SK, Lim ZW, Kota SB. Elavl1 Impacts Osteogenic Differentiation and mRNA Levels of Genes Involved in ECM Organization Front Cell Dev Biol 2021 9:606971 PubMed ID: 33614643 DOI: 10.3389/fcell.2021.606971

16795 Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R. Platelet-Rich Fibrin Decreases the Inflammatory Response of Mesenchymal Cells Int J Mol Sci 2021 22(21):11333 PubMed ID: 34768764 DOI: 10.3390/ijms222111333

11638 Crawford M, Leclerc V, Barr K, Dagnino L. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin. J. Invest. Dermatol. 2020 140(2):425-434 PubMed ID: 31330146 DOI: 10.1016/j.jid.2019.07.681

11881 Shiraishi N, Masumoto H, Takahashi K, Tenkumo T, Anada T, Suzuki O, Ogawa T, Sasaki K. Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus. Dent Mater J 2020 39(1):148-153. PubMed ID: 31666486 DOI: 10.4012/dmj.2018-376

6952 Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y. The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice. Commun Biol 2020 ;3(1):30 PubMed ID: 31949279 DOI: 10.1038/s42003-020-0754-2

12006 Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S. Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31964526 DOI: 10.1016/j.bbrc.2020.01.065

12040 Tabuchi Y, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Takeuchi SI, Shiiba M, Mochizuki T. Low-intensity pulsed ultrasound promotes the expression of immediate-early genes in mouse ST2 bone marrow stromal cells. J Med Ultrason (2001) 2020 PubMed ID: 32026128 DOI: 10.1007/s10396-020-01007-9

12123 Kawao N, Morita H, Iemura S, Ishida M, Kaji H. Roles of Dkk2 in the Linkage from Muscle to Bone during Mechanical Unloading in Mice. Int J Mol Sci 2020 PubMed ID: 32268570 DOI: 10.3390/ijms21072547

12200 Tomokazu Ohnishi, Joji Kusuyama, Kenjiro Bandow, Tetsuya Matsuguchi Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation Biochem J 2020 477(10):1795-1811 PubMed ID: 32242617 DOI: 10.1042/BCJ20190888

13151 Cornelis R, Hahne S, Taddeo A, Petkau G, Malko D, Durek P, Thiem M, Heiberger L, Peter L, Mohr E, Klaeden C, Tokoyoda K, Siracusa F, Hoyer BF, Hiepe F, Mashreghi MF, Melchers F, Chang HD, Radbruch A. Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells. Cell Rep 2020 PubMed ID: 32755576 DOI: 10.1016/j.celrep.2020.107982

13197 Yahiro Y, Maeda S, Morikawa M, Koinuma D, Jokoji G, Ijuin T, Komiya S, Kageyama R, Miyazono K, Taniguchi N. BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts. Bone Res 2020 PubMed ID: 32923015 DOI: 10.1038/s41413-020-00106-0

13352 Ma O, Le T, Talbott G, HoangThao Nguyen T, Ha D, Ho L. Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity. Pharmacol Res Perspect 2020 PubMed ID: 33191653 DOI: 10.1002/prp2.670

14181 Tsubaki M, Seki S, Takeda T, Chihara A, Arai Y, Morii Y, Imano M, Satou T, Shimomura K, Nishida S. The HGF/Met/NF-κB Pathway Regulates RANKL Expression in Osteoblasts and Bone Marrow Stromal Cells Int J Mol Sci 2020 21(21):7905 PubMed ID: 33114380 DOI: 10.3390/ijms21217905

14295 Takeda T, Tsubak M, Genno S, Matsuda T, Yamamoto Y, Ueda E, Imano M, Satou T, Nishida S. CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma J Physiol Pharmacol 2020 71(4) PubMed ID: 33214335 DOI: 10.26402/jpp.2020.4.02

14500 Asparuhova MB, Chappuis V, Stähli A, Buser D, Sculean A. Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts Clin Oral Investig 2020 24(11):3923-3937 PubMed ID: 32236725 DOI: 10.1007/s00784-020-03259-8

11318 Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation. Cytotechnology 2019 PubMed ID: 30474804 DOI: 10.1007/s10616-018-0236-2

11323 Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30502084 DOI: 10.1016/j.bbrc.2018.11.154

11366 Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B. Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling. J. Cell. Mol. Med. 2019 PubMed ID: 30614617 DOI: 10.1111/jcmm.14126

11439 Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM. Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. Cell Metab. 2019 PubMed ID: 30773468 DOI: 10.1016/j.cmet.2019.01.016

11460 Strauss FJ, Di Summa F, Stähli A, Matos L, Vaca F, Schuldt G, Gruber R. TGF-β activity in acid bone lysate adsorbs to titanium surface. Clin Implant Dent Relat Res 2019 PubMed ID: 30817088 DOI: 10.1111/cid.12734

11607 Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cell. Signal. 2019 PubMed ID: 31228531 DOI: 10.1016/j.cellsig.2019.109345

11659 Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice JBMR Plus 2019 PubMed ID: 31667457 DOI: 10.1002/jbm4.10201

11813 Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C. Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling. Dev. Cell 2019 PubMed ID: 31543445 DOI: 10.1016/j.devcel.2019.08.013

11856 Hamaya E, Fujisawa T, Tamura M. Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells. Int. J. Mol. Med. 2019 PubMed ID: 31638177 DOI: 10.3892/ijmm.2019.4376

11883 Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis. FASEB J. 2019 PubMed ID: 31675485 DOI: 10.1096/fj.201802729RRR

6927 Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019. Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. Front Immunol 2019 2019 May 28;10:1164 PubMed ID: 31191537 DOI: 10.3389/fimmu.2019.01164

6935 SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling Sains Malaysiana 2019 48(8):1697–1706 DOI: 10.17576/jsm-2019-4808-15

9727 Jinlu Dai, June Escara-Wilke, Jill M Keller, Younghun Jung, Russell S Taichman, Kenneth J Pienta, Evan T Keller Primary Prostate Cancer Educates Bone Stroma Through Exosomal Pyruvate Kinase M2 to Promote Bone Metastasis J Exp Med 2019 216(12):2883-2899 PubMed ID: 31548301 DOI: 10.1084/jem.20190158

10553 Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto and Keiichi Sasaki Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant Appl Sci 2019 9(1):172 DOI: 10.3390/app9010172

10554 Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells bioRxiv 2019 November 21 DOI: 10.1101/849638

12590 Mashimo K, Tsubaki M, Takeda T, Asano R, Jinushi M, Imano M, Satou T, Sakaguchi K, Nishida S. RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells Clin Exp Med 2019 19(1):133-141 PubMed ID: 30291461 DOI: 10.1007/s10238-018-0531-4

12591 Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation Biochem Biophys Res Commun 2019 509(2):435-440 PubMed ID: 30594398 DOI: 10.1016/j.bbrc.2018.12.093

12592 Takeno A, Kanazawa I, Tanaka KI, Notsu M, Sugimoto T. Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway Int J Mol Sci 2019 20(10):2481 PubMed ID: 31137461 DOI: 10.3390/ijms20102481

10666 Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T. Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts via Smad-independent mechanisms. Endocr. J. 2018 65:291-298 PubMed ID: 29249772 DOI: 10.1507/endocrj.EJ17-0229

10731 Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH. Cell type-specific suppression of mechanosensitive genes by audible sound stimulation. PLoS ONE 2018 13:e0188764 PubMed ID: 29385174 DOI: 10.1371/journal.pone.0188764

10764 Takeda T, Tsubaki M, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S. Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Biomed. Pharmacother. 2018 100:486-494 PubMed ID: 29477912 DOI: 10.1016/j.biopha.2018.02.019

10844 Takenaka Y, Mikami K, Seno S, Matsuda H. Automated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells. BMC Bioinformatics 2018 19:89 PubMed ID: 29745848 DOI: 10.1186/s12859-018-2072-y

11198 Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H. Coupling of bone resorption and formation by RANKL reverse signalling. Nature 2018 561(7722):195-200 PubMed ID: 30185903 DOI: 10.1038/s41586-018-0482-7

11099 Asparuhova MB, Caballe-Serrano J, Buser D, Chappuis V. Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity. Int J Oral Sci 2018 10(2):20 PubMed ID: 29895828 DOI: 10.1038/s41368-018-0021-2

11124 Kida J, Hata K, Nakamura E, Yagi H, Takahata Y, Murakami T, Maeda Y, Nishimura R. Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a. Sci Rep 2018 8(1):10375 PubMed ID: 29991769 DOI: 10.1038/s41598-018-28711-4

11153 Kuroda M, Ueda K, Kioka N. Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells. Sci Rep 2018 8(1):11581 PubMed ID: 30068914 DOI: 10.1038/s41598-018-29700-3

11193 Eppell SJ, Tong W, McMasters J, Soenjaya Y, Barbu AM, Ko A, Baskin JZ. Minor Review: An Overview of a Synthetic Nanophase Bone Substitute. Materials (Basel) 2018 11(9) PubMed ID: 30158464 DOI: 10.3390/ma11091556

4348 Kokubun K, Matsumura S, Yudasaka M, Iijima S, Shiba K. Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide. Int J Nanomedicine 2018 PubMed ID: 29588591 DOI: 10.2147/IJN.S155913

4349 Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T. Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells. Int J Mol Sci 2018 PubMed ID: 29904032 DOI: 10.3390/ijms19061772

4350 Aoto K, Ito K, Aoki S. Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts. Oncotarget 2018 PubMed ID: 30344924 DOI: 10.18632/oncotarget.26124

4351 Dubon MJ, Yu J, Choi S, Park KS. Transforming growth factor β induces bone marrow mesenchymal stem cell migration via noncanonical signals and N-cadherin. J. Cell. Physiol. 2018 PubMed ID: 28213973 DOI: 10.1002/jcp.25863

4502 Choi SM, Park JW. Multifunctional effects of a modification of SLA titanium implant surface with strontium-containing nanostructures on immunoinflammatory and osteogenic cell function. J Biomed Mater Res A 2018 106(12):3009-3020 PubMed ID: 30192064 DOI: 10.1002/jbm.a.36490

14552 Kota SK, Roening C, Patel N, Kota SB, Baron R. PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression Bone 2018 117:37-46 PubMed ID: 30189247 DOI: 10.1016/j.bone.2018.08.025

14900 Fujioka-Kobayashi M, Abd El Raouf M, Saulacic N, Kobayashi E, Zhang Y, Schaller B, Miron RJ. Superior bone-inducing potential of rhBMP9 compared to rhBMP2 J Biomed Mater Res A 2018 106(6):1561-1574. PubMed ID: 29396910 DOI: 10.1002/jbm.a.36359

9589 Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A. Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral. Clin Oral Implants Res 2017 28:327-333 PubMed ID: 26919609 DOI: 10.1111/clr.12802

9860 Fujioka-Kobayashi M, Schaller B, Saulacic N, Zhang Y, Miron RJ. Growth factor delivery of BMP9 using a novel natural bovine bone graft with integrated atelo-collagen type I: Biosynthesis, characterization, and cell behavior. J Biomed Mater Res A 2017 105:408-418 PubMed ID: 27699987 DOI: 10.1002/jbm.a.35921

9874 Fujioka-Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron RJ. An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering. J Craniomaxillofac Surg 2017 45:27-32 PubMed ID: 27840120 DOI: 10.1016/j.jcms.2016.10.008

9878 Fujioka-Kobayashi M, Schaller B, Zhang Y, Kandalam U, Hernandez M, Miron RJ. Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP). Clin Oral Investig 2017 21:1883-1893 PubMed ID: 27771827 DOI: 10.1007/s00784-016-1983-0

9967 Miron RJ, Fujioka-Kobayashi M, Zhang Y, Sculean A, Pippenger B, Shirakata Y, Kandalam U, Hernandez M. Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro. Clin Oral Investig 2017 21:2265-2272 PubMed ID: 27909893 DOI: 10.1007/s00784-016-2019-5

9975 Sato M, Suzuki T, Kawano M, Tamura M. Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells. Biomed Rep 2017 6:223-231 PubMed ID: 28357077 DOI: 10.3892/br.2016.824

10067 Zhang M, Osisami M, Dai J, Keller JM, Escara-Wilke J, Mizokami A, Keller ET. Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance. Mol. Cancer Res. 2017 15:457-466 PubMed ID: 28087740 DOI: 10.1158/1541-7786.MCR-16-0392

10074 Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F. Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metab. Clin. Exp. 2017 69:157-170 PubMed ID: 28285646 DOI: 10.1016/j.metabol.2017.01.006

10090 Kuroda M, Wada H, Kimura Y, Ueda K, Kioka N. Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes. J. Cell. Sci. 2017 130:989-1002 PubMed ID: 28115535 DOI: 10.1242/jcs.194779

10104 Chaweewannakorn W, Ariyoshi W, Okinaga T, Morikawa K, Saeki K, Maki K, Nishihara T. Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway. Biochem. Biophys. Res. Commun. 2017 485:621-626 PubMed ID: 28161637 DOI: 10.1016/j.bbrc.2017.01.181

10125 Fujioka-Kobayashi M, Schaller B, Saulacic N, Pippenger BE, Zhang Y, Miron RJ. Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2. Clin Exp Dent Res 2017 3:32-40 PubMed ID: 29744176 DOI: 10.1002/cre2.55

10316 Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H. Contribution of methylglyoxal to delayed healing of bone injury in diabetes. Mol Med Rep 2017 16:403-409 PubMed ID: 28534951 DOI: 10.3892/mmr.2017.6589

10395 Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A. Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. Int. J. Oncol. 2017 51:625-632 PubMed ID: 28656278 DOI: 10.3892/ijo.2017.4050

10401 Ouji Y, Sakagami M, Omori H, Higashiyama S, Kawai N, Kitahara T, Wanaka A, Yoshikawa M. Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells. Stem Cell Res 2017 23:50-56 PubMed ID: 28689068 DOI: 10.1016/j.scr.2017.06.013

10647 Ono-Ohmachi A, Ishida Y, Morita Y, Kato K, Y Nara T. Milk Basic Protein Facilitates Increased Bone Mass in Growing Mice. J. Nutr. Sci. Vitaminol. 2017 63:315-322 PubMed ID: 29225316 DOI: 10.3177/jnsv.63.315

14009 Chen JR, Lazarenko OP, Blackburn ML, Shankar K. Dietary factors during early life program bone formation in female rats FASEB J 2017 31(1):376-387 PubMed ID: 27733448 DOI: 10.1096/fj.201600703R

14377 Fujioka-Kobayashi M, Sawada K, Kobayashi E, Schaller B, Zhang Y, Miron RJ. Osteogenic potential of rhBMP9 combined with a bovine-derived natural bone mineral scaffold compared to rhBMP2 Clin Oral Implants Res 2017 28(4):381-387 PubMed ID: 26988608 DOI: 10.1111/clr.12804

14442 Fujioka-Kobayashi M, Schaler B, Shirakata Y, Nakamura T, Noguchi K, Zhang Y, Miron RJ. Comparison of Two Porcine Collagen Membranes Combined with rhBMP-2 and rhBMP-9 on Osteoblast Behavior In Vitro Int J Oral Maxillofac Implants 2017 32(4):e221-e230 PubMed ID: 28708926 DOI: 10.11607/jomi.5652

14448 Miron RJ, Fujioka-Kobayashi M, Buser D, Zhang Y, Bosshardt DD, Sculean A. Combination of Collagen Barrier Membrane with Enamel Matrix Derivative-Liquid Improves Osteoblast Adhesion and Differentiation Int J Oral Maxillofac Implants 2017 32(1):196-203 PubMed ID: 28095524 DOI: 10.11607/jomi.5011

14712 Fujioka-Kobayashi M, Schaller B, Zhang Y, Pippenger BE, Miron RJ. In vitro evaluation of an injectable biphasic calcium phosphate (BCP) carrier system combined with recombinant human bone morphogenetic protein (rhBMP)-9 Biomed Mater Eng 2017 28(3):293-304 PubMed ID: 28527192 DOI: 10.3233/BME-171675

7186 Park JW, Kang DG, Hanawa T. New bone formation induced by surface strontium-modified ceramic bone graft substitute. Oral Dis 2016 22:53-61 PubMed ID: 26458092 DOI: 10.1111/odi.12381

9531 Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S. RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines. Tumour Biol. 2016 37:9099-110 PubMed ID: 26762414 DOI: 10.1007/s13277-015-4761-8

9558 Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J. Oral Pathol. Med. 2016 45:730-739 PubMed ID: 26850833 DOI: 10.1111/jop.12430

9575 Dubon MJ, Park KS. The mechanisms of substance P-mediated migration of bone marrow-derived mesenchymal stem cell-like ST2 cells. Int. J. Mol. Med. 2016 37:1105-11 PubMed ID: 26936322 DOI: 10.3892/ijmm.2016.2496

9639 Yoshikawa M, Ouji Y. Induction of Inner Ear Hair Cells from Mouse Embryonic Stem Cells In Vitro. Methods Mol. Biol. 2016 1516:257-267 PubMed ID: 27032944 DOI: 10.1007/7651_2016_328

9752 Ye X, Huang H, Zhao N, Zhang J, Yang P. Inhibition of Runx2 signaling by TNF-α in ST2 murine bone marrow stromal cells undergoing osteogenic differentiation. In Vitro Cell. Dev. Biol. Anim. 2016 52:1026-1033 PubMed ID: 27401008 DOI: 10.1007/s11626-016-0068-3

9785 Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T. CXCL3 positively regulates adipogenic differentiation. J. Lipid Res. 2016 57:1806-1820 PubMed ID: 27512010 DOI: 10.1194/jlr.M067207

9882 Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep 2016 6:35930 PubMed ID: 27775020 DOI: 10.1038/srep35930

9961 Onishi T, Tazawa H, Hashimoto Y, Takeuchi M, Otani T, Nakamura S, Sakurai F, Mizuguchi H, Kishimoto H, Umeda Y, Shirakawa Y, Urata Y, Kagawa S, Fujiwara T. Tumor-specific delivery of biologics by a novel T-cell line HOZOT. Sci Rep 2016 6:38060 PubMed ID: 27901098 DOI: 10.1038/srep38060

9966 Fujioka-Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron RJ. Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential. J Clin Med 2016 5: PubMed ID: 27916889 DOI: 10.3390/jcm5120112

10871 Du M, Pan W, Duan X, Yang P, Ge S. Lower dosage of aspirin promotes cell growth and osteogenic differentiation in murine bone marrow stromal cells J Dent Sci 2016 11:315-322 PubMed ID: 30894990 DOI: 10.1016/j.jds.2016.03.009

10902 Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway Orthodontic Waves 2016 75, 105-113 DOI: 10.1016/j.odw.2016.10.007

10864 Fujioka-Kobayashi M, Sawada K, Kobayashi E, Schaller B, Zhang Y, Miron RJ. Recombinant Human Bone Morphogenetic Protein 9 (rhBMP9) Induced Osteoblastic Behavior on a Collagen Membrane Compared With rhBMP2 J Periodontol 2016 87(6):e101-7 PubMed ID: 26751345 DOI: 10.1902/jop.2016.150561

14079 Sugamori Y, Mise-Omata S, Maeda C, Aoki S, Tabata Y, Murali R, Yasuda H, Udagawa N, Suzuki H, Honma M, Aoki K. Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling Bioessays 2016 38(8):717-25 PubMed ID: 27345003 DOI: 10.1002/bies.201600104

14084 Sarker B, Li W, Zheng K, Detsch R, Boccaccini AR. Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin, and Bioactive Glass ACS Biomater Sci Eng 2016 2(12):2240-2254 PubMed ID: 33465897 DOI: 10.1021/acsbiomaterials.6b00470

7111 Endo K, Anada T, Yamada M, Seki M, Sasaki K, Suzuki O. Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles. Biomed Mater 2015 10:065019 PubMed ID: 26657659 DOI: 10.1088/1748-6041/10/6/065019

7265 Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O. Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect. Macromol Biosci 2015 15:1647-55 PubMed ID: 26200698 DOI: 10.1002/mabi.201500191

7338 Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C. MEK5 suppresses osteoblastic differentiation. Biochem. Biophys. Res. Commun. 2015 463:241-7 PubMed ID: 25998381 DOI: 10.1016/j.bbrc.2015.05.035

7434 Dubon MJ, Park KS. Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines. Exp Ther Med 2015 9:1185-1191 PubMed ID: 25780407 DOI: 10.3892/etm.2015.2291

7440 Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K. Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus. Int J Mol Sci 2015 16:5779-88 PubMed ID: 25775158 DOI: 10.3390/ijms16035779

7509 Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS Lett. 2015 589:447-54 PubMed ID: 25592835 DOI: 10.1016/j.febslet.2014.12.031

7511 Li C, Shi C, Kim J, Chen Y, Ni S, Jiang L, Zheng C, Li D, Hou J, Taichman RS, Sun H. Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling. J. Dent. Res. 2015 94:455-63 PubMed ID: 25586589 DOI: 10.1177/0022034514566431

7570 Y Ezoe, T Anada, H Yamazaki, T Handa, K Kobayashi, T Takahashi, O. Suzuki Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering. J Nanoparticle Res. 2015 17:127 DOI: 10.1007/s11051-015-2864-1

8888 Abe-Ohya R, Ishikawa T, Shiozawa H, Suda K, Nara F. Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists. J Recept Signal Transduct Res 2015 35(5):485-92 PubMed ID: 26053506 DOI: 10.3109/10799893.2015.1015736

6619 Peng J, Nemec M, Brolese E, Bosshardt DD, Schaller B, Buser D, Gruber R Bone-Conditioned Medium Inhibits Osteogenic and Adipogenic Differentiation of Mesenchymal Cells In Vitro. Clin Implant Dent Relat Res 2015 17(5):938-49 PubMed ID: 24461197 DOI: 10.1111/cid.12200

9369 Hirom iHagiwara, Roshan Basnet, Sundari I.Wiyasihati, Kyoko Nakata, Keitaro Hagiwara, Hitoshi Miyazaki, Kaoru Yoshida Carnosic acid inhibits the formation of osteoclasts through attenuation of expression of RANKL PharmaNutrition 2015 3:1-6 DOI: 10.1016/j.phanu.2014.11.003

9397 Shoichi Kaneshiro, Kosuke Ebina, Kenrin Shi, Kiyoshi Yoshida, Dai Otsuki, Hideki Yoshikawa, Chikahisa Higuchi Bruton Tyrosine Kinase (Btk) Suppresses Osteoblastic Differentiation J Bone Miner Metab 2015 33(5):486-95 PubMed ID: 25230818 DOI: 10.1007/s00774-014-0612-8

12236 K Sawada, J Caballé-Serrano, G Schuldt Filho, D D Bosshardt, B Schaller, D Buser 6, R Gruber Thermal processing of bone: in vitro response of mesenchymal cells to bone-conditioned medium Int J Oral Maxillofac Surg 2015 44(8):1060-6 PubMed ID: 25868709 DOI: 10.1016/j.ijom.2015.03.012

14310 Filho GS, Caballé-Serrano J, Sawada K, Bosshardt DD, Bianchini MA, Buser D, Gruber R. Conditioned medium of demineralized freeze-dried bone activates gene expression in periodontal fibroblasts in vitro J Periodontol 2015 86(6):827-34 PubMed ID: 25786563 DOI: 10.1902/jop.2015.140676

13891 Nakamura R, Kayamori K, Oue E, Sakamoto K, Harada K, Yamaguchi A. Transforming growth factor-β synthesized by stromal cells and cancer cells participates in bone resorption induced by oral squamous cell carcinoma Biochem Biophys Res Commun 2015 458(4):777-82 PubMed ID: 25681764 DOI: 10.1016/j.bbrc.2015.02.013

6031 Hattori H, Ishihara M. Altered protein secretions during interactions between adipose tissue- or bone marrow-derived stromal cells and inflammatory cells Stem Cell Res Ther 2015 6(1):70 PubMed ID: 25884474 DOI: 10.1186/s13287-015-0052-y

5203 Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity. Bone 2014 281-91 PubMed ID: 25064526 DOI: 10.1016/j.bone.2014.07.005

2777 Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, Sakurai K, Nishihara T. The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. J Biol Chem 2014 289(27):19191-203 PubMed ID: 24821724 DOI: 10.1074/jbc.M114.551416

6592 Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y. Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development. PLoS One 2014 9(3):e91421 PubMed ID: 24618907 DOI: 10.1371/journal.pone.0091421

6604 Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S. Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. J Biol Chem 2014 89(14):9865-79 PubMed ID: 24563464 DOI: 10.1074/jbc.M113.520585

6610 Nishikawa R, Anada T, Ishiko-Uzuka R, Suzuki O. Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway. Dent Mater J 2014 33(2):242-51 PubMed ID: 24598239 DOI: 10.4012/dmj.2013-226

9332 Joji Kusuyama, Kenjiro Bandow, Mitsuo Shamoto, Kyoko Kakimoto, Tomokazu Ohnishi, Tetsuya Matsuguchi Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines Through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway J Biol Chem 2014 289(15):10330-44 PubMed ID: 24550383 DOI: 10.1074/jbc.M113.546382

9336 Ken-ichiro Tanaka, Hiroshi Kaji, Toru Yamaguchi, Ippei Kanazawa, Lucie Canaff, Geoffrey N Hendy, Toshitsugu Sugimoto Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK-eIF2α-ATF4 Pathway in the Commitment of Myoblastic Into Osteoblastic Cells Calcif Tissue Int 2014 94(4):454-64 PubMed ID: 24362451 DOI: 10.1007/s00223-013-9828-1

9345 Sunao Takeshita, Toshio Fumoto, Yoshinori Naoe, Kyoji Ikeda Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL J Biol Chem 2014 289(24):16699-710 PubMed ID: 24753250 DOI: 10.1074/jbc.M114.547919

9347 Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M Keller, Kenneth M Kozloff, Dana T Aftab, Frauke Schimmoller, Evan T Keller Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions Clin Cancer Res 2014 20(3):617-30 PubMed ID: 24097861 DOI: 10.1158/1078-0432.CCR-13-0839

9348 W Ariyoshi, T Okinaga, C B Knudson, W Knudson, T Nishihara High Molecular Weight Hyaluronic Acid Regulates Osteoclast Formation by Inhibiting Receptor Activator of NF-κB Ligand Through Rho Kinase Osteoarthritis Cartilage 2014 22(1):111-20 PubMed ID: 24185105 DOI: 10.1016/j.joca.2013.10.013

9350 Masakazu Notsu, Toru Yamaguchi, Kyoko Okazaki, Ken-ichiro Tanaka, Noriko Ogawa, Ippei Kanazawa, Toshitsugu Sugimoto Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion Endocrinology 2014 155(7):2402-10 PubMed ID: 24758301 DOI: 10.1210/en.2013-1818

9352 Kiyoshi Mori, Riko Kitazawa, Takeshi Kondo, Michiko Mori, Yasuhiro Hamada, Michiru Nishida, Yasuhiro Minami, Ryuma Haraguchi, Yutaka Takahashi, Sohei Kitazawa Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene PLoS One 2014 9(7):e102797 PubMed ID: 25036934 DOI: 10.1371/journal.pone.0102797

9271 Masato Tamura, Maki Uyama, Yuri Sugiyama, Mari Sato Canonical Wnt Signaling Activates miR-34 Expression During Osteoblastic Differentiation Mol Med Rep 2013 8(6):1807-11 PubMed ID: 24100761 DOI: 10.3892/mmr.2013.1713

9278 Shingen Nakamura, Hirokazu Miki, Shinsuke Kido, Ayako Nakano, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Keiichiro Watanabe, Takeshi Harada, Shiro Fujii, Kyoko Takeuchi, Kumiko Kagawa, Shuji Ozaki, Toshio Matsumoto, Masahiro Abe Activating Transcription Factor 4, an ER Stress Mediator, Is Required For, but Excessive ER Stress Suppresses Osteoblastogenesis by Bortezomib Int J Hematol 2013 98(1):66-73 PubMed ID: 23708974 DOI: 10.1007/s12185-013-1367-z

9289 Yuan Jiang, Jinlu Dai, Honglai Zhang, Joe L Sottnik, Jill M Keller, Katherine J Escott, Hitesh J Sanganee, Zhi Yao, Laurie K McCauley, Evan T Keller Activation of the Wnt Pathway Through AR79, a GSK3β Inhibitor, Promotes Prostate Cancer Growth in Soft Tissue and Bone Mol Cancer Res 2013 11(12):1597-610 PubMed ID: 24088787 DOI: 10.1158/1541-7786.MCR-13-0332-T

9292 James J Cody, Angel A Rivera, Gray R Lyons, Sherry W Yang, Minghui Wang, Jason W Ashley, Sreelatha Meleth, Xu Feng, Gene P Siegal, Joanne T Douglas Expression of Osteoprotegerin From a Replicating Adenovirus Inhibits the Progression of Prostate Cancer Bone Metastases in a Murine Model Lab Invest 2013 93(3):268-78 PubMed ID: 23358109 DOI: 10.1038/labinvest.2012.179

10992 Yasuhiro Takenaka, Ikuo Inoue, Takanari Nakano, Yuichi Shinoda, Masaaki Ikeda, Takuya Awata, Shigehiro Katayama A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2 PLoS One 2013 8(6):e65583 PubMed ID: 23840343 DOI: 10.1371/journal.pone.0065583

12708 Kim Y, Kelly OJ, Ilich JZ. Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth Lipids 2013 48(8):787-802 PubMed ID: 23757205 DOI: 10.1007/s11745-013-3803-5

7600 Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O. The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects. Acta Biomater 2012 8:1190-200 PubMed ID: 22198138 DOI: 10.1016/j.actbio.2011.12.002

7673 Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A. Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction. Oral Oncol. 2012 48:49-55 PubMed ID: 21945071 DOI: 10.1016/j.oraloncology.2011.08.026

6097 Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A. CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction. Biochem Biophys Res Commun 2012 424(3):456-61 PubMed ID: 22771802 DOI: 10.1016/j.bbrc.2012.06.132

6102 Tsubaki M, Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S. Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2. Mol Cell Endocrinol 2012 361(1-2):219-31 PubMed ID: 22579611 DOI: 10.1016/j.mce.2012.05.002

9248 Y Ouji, S Ishizaka, F Nakamura-Uchiyama, M Yoshikawa In Vitro Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Hair Cell-Like Cells Using Stromal Cell Conditioned Medium Cell Death Dis 2012 3(5):e314 PubMed ID: 22622133 DOI: 10.1038/cddis.2012.56

9251 Shoichiro Kokabu, Laura Gamer, Karen Cox, Jonathan Lowery, Kunikazu Tsuji, Regina Raz, Aris Economides, Takenobu Katagiri, Vicki Rosen BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction With Acvr2b Mol Endocrinol 2012 26(1):87-94 PubMed ID: 22074949 DOI: 10.1210/me.2011-1168

7674 Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P. Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells. Cell Prolif. 2011 44:420-7 PubMed ID: 21951285 DOI: 10.1111/j.1365-2184.2011.00769.x

7774 Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K. Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292. Clin. Exp. Metastasis 2011 28:649-59 PubMed ID: 21688034 DOI: 10.1007/s10585-011-9398-4

7829 Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S. Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells. Arch. Pharm. Res. 2011 34:469-75 PubMed ID: 21547680 DOI: 10.1007/s12272-011-0316-8

7921 Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Exp. Cell Res. 2011 317:1134-46 PubMed ID: 21338601 DOI: 10.1016/j.yexcr.2011.02.008

7943 Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH. A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 2011 286:12328-39 PubMed ID: 21324897 DOI: 10.1074/jbc.M110.176099

7955 Tamura M, Sato MM, Nashimoto M. Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells. Int. J. Biochem. Cell Biol. 2011 43:760-7 PubMed ID: 21296678 DOI: 10.1016/j.biocel.2011.01.021

8004 Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M. Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations. Exp. Cell Res. 2011 317:745-56 PubMed ID: 21211534 DOI: 10.1016/j.yexcr.2010.12.015

8069 Tsuneto M, Yamane T, Hayashi S. Methods for investigation of osteoclastogenesis using mouse embryonic stem cells. Methods Mol. Biol. 2011 690:239-53 PubMed ID: 21042997 DOI: 10.1007/978-1-60761-962-8_16

8575 Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa, Hiroshi Suzuki Rab27a and Rab27b Are Involved in Stimulation-Dependent RANKL Release From Secretory Lysosomes in Osteoblastic Cells J Bone Miner Res 2011 26(4):689-703 PubMed ID: 20939018 DOI: 10.1002/jbmr.268

8102 Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells. Biol. Pharm. Bull. 2010 33:1733-9 PubMed ID: 20930384 DOI: 10.1248/bpb.33.1733

8113 Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol. Cancer Ther. 2010 9:2960-9 PubMed ID: 20858724 DOI: 10.1158/1535-7163.MCT-10-0489

8139 Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT. Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer. Cancer Gene Ther. 2010 17:893-905 PubMed ID: 20798695 DOI: 10.1038/cgt.2010.47

8182 Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K. Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway. Bone 2010 47:756-65 PubMed ID: 20637325 DOI: 10.1016/j.bone.2010.07.008

8220 Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M. Cytodifferentiation activity of synthetic human enamel sheath protein peptides. J. Periodont. Res. 2010 45:643-9 PubMed ID: 20572923 DOI: 10.1111/j.1600-0765.2010.01279.x

8295 Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet 2010 6(7):e1001019 PubMed ID: 20628571 DOI: 10.1371/journal.pgen.1001019

16149 Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells Am J Pathol 2010 176(2):968-80 PubMed ID: 20035059 DOI: 10.2353/ajpath.2010.090299

8359 Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology 2009 61:125-34 PubMed ID: 20162352 DOI: 10.1007/s10616-010-9253-5

8493 Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 2009 114:4441-50 PubMed ID: 19762485 DOI: 10.1182/blood-2009-07-233718

8530 Yoshikawa H, Yoshioka K, Nakase T, Itoh K. Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study. Clin. Orthop. Relat. Res. 2009 467:3087-95 PubMed ID: 19609629 DOI: 10.1007/s11999-009-0976-6

8570 Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O. Octacalcium phosphate-precipitated alginate scaffold for bone regeneration. Tissue Eng Part A 2009 15:3525-35 PubMed ID: 19456237 DOI: 10.1089/ten.TEA.2009.0048

8584 Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T. Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. Anticancer Res. 2009 29:1089-94 PubMed ID: 19414350

8594 Mogi M, Kondo A. Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells. Biochem. Biophys. Res. Commun. 2009 384:82-6 PubMed ID: 19393224 DOI: 10.1016/j.bbrc.2009.04.084

8652 Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K. Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing. J. Bone Miner. Metab. 2009 27:355-63 PubMed ID: 19229473 DOI: 10.1007/s00774-009-0040-3

8669 Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O. The effect of microstructure of octacalcium phosphate on the bone regenerative property. Tissue Eng Part A 2009 15:1965-73 PubMed ID: 19132890 DOI: 10.1089/ten.tea.2008.0300

8766 Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T. Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads. J Biomed Mater Res A 2009 88:599-607 PubMed ID: 18314893 DOI: 10.1002/jbm.a.31833

6536 Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol 2009 9:70 PubMed ID: 20025746 DOI: 10.1186/1471-213X-9-70

8180 Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells. BMC Musculoskelet Disord 2009 10:109 PubMed ID: 19728893 DOI: 10.1186/1471-2474-10-109

8183 Nose M, Yamazaki H, Hagino H, Morio Y, Hayashi S, Teshima R. Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients. J Bone Miner Metab 2009 27(1):57-65 PubMed ID: 19082778 DOI: 10.1007/s00774-008-0011-0

6530 Anada T, Kumagai T, Honda Y, Masuda T, Kamijo R, Kamakura S, Yoshihara N, Kuriyagawa T, Shimauchi H, Suzuki O. Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells. Tissue Eng Part A 2008 14(6):965-78 PubMed ID: 19230123 DOI: 10.1089/tea.2007.0339

7863 Maehira F1, Iinuma Y, Eguchi Y, Miyagi I, Teruya S. Effects of soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice. J Bone Miner Metab 2008 26(5):446-55 PubMed ID: 18758902 DOI: 10.1007/s00774-007-0845-x

7919 Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K. Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells. J Bone Miner Metab 2008 26(2):152-8 PubMed ID: 18301971 DOI: 10.1007/s00774-007-0803-7

7920 Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y. Effects of alkylphenols on bone metabolism in vivo and in vitro. Toxicol Lett 2008 181(1):13-8 PubMed ID: 18621119 DOI: 10.1016/j.toxlet.2008.06.863

7930 You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 2008 42(1):172-9 PubMed ID: 17997378 DOI: 10.1016/j.bone.2007.09.047

7073 Tsubaki M, Kato C, Manno M, Ogaki M, Satou T, Itoh T, Kusunoki T, Tanimori Y, Fujiwara K, Matsuoka H, Nishida S. Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways. Mol Cell Biochem 2007 304(1-2):53-60 PubMed ID: 17549607 DOI: 10.1007/s11010-007-9485-7

7354 Takahashi N, Udagawa N, Kobayashi Y, Suda T. Generation of osteoclasts in vitro, and assay of osteoclast activity. Methods Mol Med 2007 135:285-301 PubMed ID: 17951666 DOI: 10.1007/978-1-59745-401-8_18

7383 Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B. Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem 2007 102(6):1458-71 PubMed ID: 17486635 DOI: 10.1002/jcb.21366

7386 Amano S, Arai M, Goto S, Togari A. Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells. Biochim Biophys Acta 2007 1770(6):966-73 PubMed ID: 17383824 DOI: 10.1016/j.bbagen.2007.02.009

7391 Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y. Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner. J Immunol 2007 179(10):6715-24 PubMed ID: 17982061 DOI: 10.4049/jimmunol.179.10.6715

7392 Niikura K, Nakajima S, Takano M, Yamazaki H. FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats. Bone 2007 40(4):888-94 PubMed ID: 17157574 DOI: 10.1016/j.bone.2006.10.015

13955 Nakagawa K, Imai Y, Ohta Y, Takaoka K. Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation Bone 2007 41(4):543-8 PubMed ID: 17681894 DOI: 10.1016/j.bone.2007.06.013

8891 Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N. Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells. J Biomed Mater Res A 2006 77:507-11 PubMed ID: 16482552 DOI: 10.1002/jbm.a.30661

8913 Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro J Hard Tissue Biology 2006 15:27-33 DOI: 10.2485/jhtb.15.27

6151 Nagayoshi K, Ohkawa H, Yorozu K, Higuchi M, Higashi S, Kubota N, Fukui H, Imai N, Gojo S, Hata J, Kobayashi Y, Umezawa A. Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification. J Cell Physiol 2006 208(1):188-94 PubMed ID: 16575918 DOI: 10.1002/jcp.20652

6493 Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006 99(1):196-208 PubMed ID: 16598753 DOI: 10.1002/jcb.20890

6997 Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K. Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells. Bone 2006 38(2):206-14 PubMed ID: 16203197 DOI: 10.1016/j.bone.2005.08.006

7012 Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T. CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol 2006 26(16):6105-16 PubMed ID: 16880521 DOI: 10.1128/MCB.02429-05

7024 Shin HH, Kim SJ, Kang SY, Lee DS, Choi HS. Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprotegerin in bone marrow stromal cells. Bone 2006 39(4):716-23 PubMed ID: 16750437 DOI: 10.1016/j.bone.2006.03.015

12830 Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano A. Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis Microbes Infect 2006 8(4):1025-34 PubMed ID: 16476562 DOI: 10.1016/j.micinf.2005.10.021

13953 Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M. Porcine enamel protein fractions contain transforming growth factor-beta1 J Periodontol 2006 77(10):1688-94 PubMed ID: 17032111 DOI: 10.1902/jop.2006.050352

13957 Suzuki O, Kamakura S, Katagiri T, Nakamura M, Zhao B, Honda Y, Kamijo R. Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite Biomaterials 2006 27(13):2671-81 PubMed ID: 16413054 DOI: 10.1016/j.biomaterials.2005.12.004

3294 Deshimaru, Ryota, Ishitani, Ken, Makita, Kazuya, Horiguchi, Fumi, Nozawa, Shiro Analysis of fatty acid composition in human bone marrow aspirates. Keio J Med 2005 54:150-5 PubMed ID: 16237277 DOI: 10.2302/kjm.54.150

2879 Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. Biochem Biophys Res Commun 2005 328:91-7 PubMed ID: 15670755 DOI: 10.1016/j.bbrc.2004.12.145

3366 Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis. Am J Physiol Cell Physiol 2005 288:C156-68 PubMed ID: 15342339 DOI: 10.1152/ajpcell.00092.2004

3183 Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol 2005 25:1971-9 PubMed ID: 15713650 DOI: 10.1128/MCB.25.5.1971-1979.2005

2843 Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Am J Pathol 2005 166:1817-26 PubMed ID: 15920166 DOI: 10.1016/S0002-9440(10)62491-1

3377 Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res 2005 65:7554-60 PubMed ID: 16140917 DOI: 10.1158/0008-5472.CAN-05-1317

8993 Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N. Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells. J Biomed Mater Res A 2005 75:210-5 PubMed ID: 16059889 DOI: 10.1002/jbm.a.30416

9055 Kandler B, Maitz P, Fischer MB, Watzek G, Gruber R. Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation. Bone 2005 36:671-7 PubMed ID: 15784190 DOI: 10.1016/j.bone.2005.01.015

6866 O. Suzuki　et al Effects of mechanical stress and scaffold material on osteogenesis and chondrogenesis IEEE Xplore 2005 DOI: 10.1109/MHS.2005.1589996

6870 Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL. Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone 2005 37(3):313-22 PubMed ID: 16023419 DOI: 10.1016/j.bone.2005.04.040

6877 Liu J, Yang H, Liu W, Cao X, Feng X. Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. J Cell Biochem 2005 96(4):716-27 PubMed ID: 16052479 DOI: 10.1002/jcb.20569

2871 Notoya M, Otsuka E, Yamaguchi A, Hagiwara H Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochem Biophys Res Commun 2004 324:655-60 PubMed ID: 15474477 DOI: 10.1016/j.bbrc.2004.09.101

2910 Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology 2004 145:751-9 PubMed ID: 14563699 DOI: 10.1210/en.2003-0726

2926 French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004 165:855-67 PubMed ID: 15331410 DOI: 10.1016/S0002-9440(10)63348-2

6737 Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H. Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells. Biochem Pharmacol 2004 67(1):119-27 PubMed ID: 14667934 DOI: 10.1016/j.bcp.2003.08.038

6739 Karst M, Gorny G, Galvin RJ, Oursler MJ. Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation. J Cell Physiol 2004 200(1):99-106 PubMed ID: 15137062 DOI: 10.1002/jcp.20036

15606 Gorny G, Shaw A, Oursler MJ. IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro Exp Cell Res 2004 294(1):149-58 PubMed ID: 14980510 DOI: 10.1016/j.yexcr.2003.11.009

16483 Osteopontin as a positive regulator in the osteoclastogenesis of arthritis Biochem Biophys Res Commun 2004 316(3):809-15 PubMed ID: 15033472 DOI: 10.1016/j.bbrc.2004.02.124

3059 Tazoe, Michiko, Mogi, Makio, Goto, Shigemi, Togari, Akifumi Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells. Arch Oral Biol 2003 48:615-9 PubMed ID: 12828991 DOI: 10.1016/s0003-9969(03)00100-6

5407 Yamagami H, Nishioka T, Ochiai E, Fukushima K, Nomura M, Kasugai S, Moritani S, Yokogawa K, Miyamoto K. Inhibition of osteoclastogenesis by a phosphodiesterase 4 inhibitor XT-611 through synergistic action with endogenous prostaglandin E2. Biochem Pharmacol 2003 66(5):801-7 PubMed ID: 12948861 DOI: 10.1016/s0006-2952(03)00409-x

4964 Gruber R, Graninger W, Bobacz K, Watzek G, Erlacher L. BMP-6-induced osteogenic differentiation of mesenchymal cell lines is not modulated by sex steroids and resveratrol. Cytokine 2003 23(4-5):133-7 PubMed ID: 12967649 DOI: 10.1016/s1043-4666(03)00223-0

4415 Itoh F, Aoyagi S, Furihata-Komatsu H, Aoki M, Kusama H, Kojima M, Kogo H. Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures. Eur J Pharmacol 2003 477(1):9-16 PubMed ID: 14512092 DOI: 10.1016/j.ejphar.2003.08.011

6629 Takahashi N, Udagawa N, Tanaka S, Suda T. Generating murine osteoclasts from bone marrow. Methods Mol Med 2003 80:129-44 PubMed ID: 12728715 DOI: 10.1385/1-59259-366-6:129

6662 Fratzl-Zelman N, Glantschnig H, Rumpler M, Nader A, Ellinger A, Varga F. The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones. Cell Biol Int 2003 27(6):459-68 PubMed ID: 12798773 DOI: 10.1016/s1065-6995(03)00037-4

6696 Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003 144(2):681-92 PubMed ID: 12538631 DOI: 10.1210/en.2002-220682

6697 Ding J, Nagai K, Woo JT. Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Biosci Biotechnol Biochem 2003 67(2):314-21 PubMed ID: 12728992 DOI: 10.1271/bbb.67.314

6704 Ha H, Ho J, Shin S, Kim H, Koo S, Kim IH, Kim C. Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition. Arch Pharm Res 2003 26(11):929-36 PubMed ID: 14661859 DOI: 10.1007/bf02980202

6707 Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y. Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res 2003 18(2):360-9 PubMed ID: 12568414 DOI: 10.1359/jbmr.2003.18.2.360

15417 Shalhoub V, Grisanti M, Padagas J, Scully S, Rattan A, Qi M, Varnum B, Vezina C, Lacey D, Martin D. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells Crit Rev Eukaryot Gene Expr 2003 13(2-4):89-106 PubMed ID: 14696958 DOI: 10.1615/critreveukaryotgeneexpr.v13.i24.30

16305 Nagano M, Ryu BY, Brinster CJ, Avarbock MR, Brinster RL. Maintenance of mouse male germ line stem cells in vitro Biol Reprod 2003 68(6):2207-14 PubMed ID: 12606373 DOI: 10.1095/biolreprod.102.014050

2518 Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect J Periodontal Res 2003 38(3):333-42 PubMed ID: 12753373 DOI: 10.1034/j.1600-0765.2003.00667.x

2773 Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP). Cell Tissue Res 2002 309:269-79 PubMed ID: 12172786 DOI: 10.1007/s00441-002-0587-y

2546 Kitazawa, Riko, Kitazawa, Sohei Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter. Biochem Biophys Res Commun 2002 290:650-5 PubMed ID: 11785948 DOI: 10.1006/bbrc.2001.6251

3000 Sakuta K, Sakai H, Mori H, Morihata H, Kuno M Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts. Bone 2002 31:374-80 PubMed ID: 12231409 DOI: 10.1016/s8756-3282(02)00838-4

2999 Sakuta, Koichi, Morihata, Hirokazu, Mori, Hiroyuki, Sakai, Hiromu, Kuno, Miyuki Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts. Osaka City Med J 2002 48:29-38 PubMed ID: 12375695

3582 Miura M, Tanaka K, Komatsu Y, Suda M, Yasoda A, Sakuma Y, Ozasa A, Nakao K. A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation. Biochem Biophys Res Commun 2002 291(4):987-94 PubMed ID: 11866463 DOI: 10.1006/bbrc.2002.6561

6673 Kuriyama K, Higuchi C, Tanaka K, Yoshikawa H, Itoh K. A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein-2-induced bone formation in vivo. Biochem Biophys Res Commun 2002 299(5):903-9 PubMed ID: 12470665 DOI: 10.1016/s0006-291x(02)02754-7

6675 Tsutsumimoto T, Wakabayashi S, Kinoshita T, Horiuchi H, Takaoka K. A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cells. Bone 2002 31(3):396-401 PubMed ID: 12231412 DOI: 10.1016/s8756-3282(02)00839-6

6684 Kitazawa S, Kitazawa R. Epigenetic control of mouse receptor activator of NF-kappa B ligand gene expression. Biochem Biophys Res Commun 2002 293(1):126-31 PubMed ID: 12054573 DOI: 10.1016/S0006-291X(02)00189-4

6692 Wakabayashi S, Tsutsumimoto T, Kawasaki S, Kinoshita T, Horiuchi H, Takaoka K. Involvement of phosphodiesterase isozymes in osteoblastic differentiation. J Bone Miner Res 2002 17(2):249-56 PubMed ID: 11811555 DOI: 10.1359/jbmr.2002.17.2.249

6693 Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T. Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem 2002 277(50):49011-8 PubMed ID: 12384500 DOI: 10.1074/jbc.M207804200

6698 Goseki-Sone M, Yamada A, Hamatani R, Mizoi L, Iimura T, Ezawa I. Phosphate depletion enhances bone morphogenetic protein-4 gene expression in a cultured mouse marrow stromal cell line ST2. Biochem Biophys Res Commun 2002 ;299(3):395-9 PubMed ID: 12445813 DOI: 10.1016/s0006-291x(02)02646-3

6699 Tang L, Ebara S, Kawasaki S, Wakabayashi S, Nikaido T, Takaoka K. FK506 enhanced osteoblastic differentiation in mesenchymal cells. Cell Biol Int 2002 26(1):75-84 PubMed ID: 11779223 DOI: 10.1006/cbir.2001.0812

6700 Mikuni-Takagaki Y, Naruse K, Azuma Y, Miyauchi A. The role of calcium channels in osteocyte function. J Musculoskelet Neuronal Interact 2002 2(3):252-5 PubMed ID: 15758446

6702 Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology 2002 143(6):2349-56 PubMed ID: 12021200 DOI: 10.1210/endo.143.6.8854

17294 Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway J Biol Chem 2002 277(16):14221-6 PubMed ID: 11827970 DOI: 10.1074/jbc.M111551200

17296 Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo J Clin Endocrinol Metab 2002 87(9):4273-9 PubMed ID: 12213884 DOI: 10.1210/jc.2002-020656

17299 Ishida A, Fujita N, Kitazawa R, Tsuruo T. Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone J Biol Chem 2002 277(29):26217-24 PubMed ID: 12011070 DOI: 10.1074/jbc.M111093200

2771 Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers. J Bone Miner Metab 2001 19:220-7 PubMed ID: 11448014 DOI: 10.1007/s007740170024

2772 Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines. Cell Tissue Res 2001 304:351-9 PubMed ID: 11456411 DOI: 10.1007/s004410100347

6657 Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 2001 166(5):3574-9 PubMed ID: 11207318 DOI: 10.4049/jimmunol.166.5.3574

6663 Yamagishi T, Otsuka E, Hagiwara H. Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis. Endocrinology 2001 142(8):3632-7 PubMed ID: 11459812 DOI: 10.1210/endo.142.8.8310

6666 Ding J, Woo JT, Nagai K. The effects of retinoic acid on reversing the adipocyte differentiation into an osteoblastic tendency in ST2 cells, a murine bone marrow-derived stromal cell line. Cytotechnology 2001 36(1-3):125-36 PubMed ID: 19003323 DOI: 10.1023/A:1014056012278

16947 Fan X, Fan D, Gewant H, Royce CL, Nanes MS, Rubin J. Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells Am J Physiol Endocrinol Metab 2001 280(1):E103-11. PubMed ID: 11120664 DOI: 10.1152/ajpendo.2001.280.1.E103

16962 Yano K, Shibata O, Mizuno A, Kobayashi F, Higashio K, Morinaga T, Tsuda E. Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy Biochem Biophys Res Commun 2001 288(1):217-24 PubMed ID: 11594776 DOI: 10.1006/bbrc.2001.5745

17283 Yamanaka R, Zullo SA, Tanaka R, Blaese M, Xanthopoulos KG. Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki forest virus-mediated complementary DNA J Neurosurg 2001 94(3):474-81 PubMed ID: 11235953 DOI: 10.3171/jns.2001.94.3.0474

2430 Otsuka E, Kato Y, Hirose S, Hagiwara H Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 2000 141:3006-11 PubMed ID: 10919289 DOI: 10.1210/endo.141.8.7597

5400 Kawaguchi N, Noda M. Mitf is expressed in osteoclast progenitors in vitro. Exp Cell Res 2000 260(2):284-91 PubMed ID: 11035923 DOI: 10.1006/excr.2000.5020

3984 Naruse K, Mikuni-Takagaki Y, Azuma Y, Ito M, Oota T, Kameyama K, Itoman M. Anabolic response of mouse bone-marrow-derived stromal cell clone ST2 cells to low-intensity pulsed ultrasound. Biochem Biophys Res Commun 2000 268(1):216-20 PubMed ID: 10652238 DOI: 10.1006/bbrc.2000.2094

3987 Gruber R, Nothegger G, Ho GM, Willheim M, Peterlik M. Differential stimulation by PGE(2) and calcemic hormones of IL-6 in stromal/osteoblastic cells. Biochem Biophys Res Commun 2000 270(3):1080-5 PubMed ID: 10772953 DOI: 10.1006/bbrc.2000.2573

3988 Koyama A, Otsuka E, Inoue A, Hirose S, Hagiwara H. Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2). Eur J Pharmacol 2000 391(3):225-31 PubMed ID: 10729362 DOI: 10.1016/s0014-2999(00)00100-x

3990 Takami M, Takahashi N, Udagawa N, Miyaura C, Suda K, Woo JT, Martin TJ, Nagai K, Suda T. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 2000 141(12):4711-9 PubMed ID: 11108286 DOI: 10.1210/endo.141.12.7852

3996 Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone 2000 27(6):769-76 PubMed ID: 11113387 DOI: 10.1016/s8756-3282(00)00396-3

13683 Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity Blood 2000 96(5):1953-60. PubMed ID: 10961900

1898 Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines Biochem Biophys Res Commun 2000 275(3):768-75 PubMed ID: 10973797 DOI: 10.1006/bbrc.2000.3379

2998 Sakai H, Nakamura F, Kuno M Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts J Physiol 1999 515:157-168 PubMed ID: 9925886 DOI: 10.1111/j.1469-7793.1999.157ad.x

2545 Kitazawa R, Kitazawa S, Maeda S Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1999 1445:134-41 PubMed ID: 10209265 DOI: 10.1016/s0167-4781(99)00032-9

2370 Otsuka E, Yamaguchi A, Hirose S, Hagiwara H Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid Am J Physiol 1999 277(1 Pt 1):132-138 PubMed ID: 10409116 DOI: 10.1152/ajpcell.1999.277.1.C132

2420 Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol 1999 383:387-93 PubMed ID: 10594333 DOI: 10.1016/s0014-2999(99)00551-8

5398 Shalhoub V, Faust J, Boyle WJ, Dunstan CR, Kelley M, Kaufman S, Scully S, Van G, Lacey DL. Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. J Cell Biochem 1999 72(2):251-61 PubMed ID: 10022507

3960 Fujiwara M, Tagashira S, Harada H, Ogawa S, Katsumata T, Nakatsuka M, Komori T, Takada H. Isolation and characterization of the distal promoter region of mouse Cbfa1. Biochim Biophys Acta 1999 1446(3):265-72 PubMed ID: 10524201 DOI: 10.1016/s0167-4781(99)00113-x

3964 Nagai M, Sato N. Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochem Biophys Res Commun 1999 257(3):719-23 PubMed ID: 10208850 DOI: 10.1006/bbrc.1999.0524

3967 Tomohiro ShimizuJe-Tae WooKazuo Nagai Screening for Bioactive Compounds that Induce the Differentiation of Bone Marrow-Derived Preadipocytic Cell Line, ST2, into the Cells of Osteoblastic Phenotype Animal Cell Technology: Basic & Applied Aspects 1999 10:353–356 DOI: 10.1007/0-306-46865-4_61

3973 Goseki-Sone M, Yamada A, Asahi K, Hirota A, Ezawa I, Iimura T. Phosphate depletion enhances tissue-nonspecific alkaline phosphatase gene expression in a cultured mouse marrow stromal cell line ST2. Biochem Biophys Res Commun 1999 265(1):24-8 PubMed ID: 10548485 DOI: 10.1006/bbrc.1999.1624

3529 Quinn JM, Morfis M, Lam MH, Elliott J, Kartsogiannis V, Williams ED, Gillespie MT, Martin TJ, Sexton PM. Calcitonin receptor antibodies in the identification of osteoclasts. Bone 1999 25(1):1-8 PubMed ID: 10423015 DOI: 10.1016/s8756-3282(99)00094-0

6648 Isaacs SD, Fan X, Fan D, Gewant H, Murphy TC, Farmer P, Taylor WR, Nanes MS, Rubin J. Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells. J Cell Physiol 1999 179(2):193-200 PubMed ID: 10199558 DOI: 10.1002/(SICI)1097-4652(199905)179:2<193::AID-JCP9>3.0.CO;2-3

13802 Yano K, Tsuda E, Washida N, Kobayashi F, Goto M, Harada A, Ikeda K, Higashio K, Yamada Y. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis J Bone Miner Res 1999 14(4):518-27 PubMed ID: 10234572 DOI: 10.1359/jbmr.1999.14.4.518

2274 Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms. J Bone Miner Res 1998 13:986-95 PubMed ID: 9626630 DOI: 10.1359/jbmr.1998.13.6.986

3943 Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K, Akatsu T. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun. 1998 252(3):747-52 PubMed ID: 9837778 DOI: 10.1006/bbrc.1998.9723

3947 Takai H, Kanematsu M, Yano K, Tsuda E, Higashio K, Ikeda K, Watanabe K, Yamada Y. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem 1998 273(42):27091-6 PubMed ID: 9765225 DOI: 10.1074/jbc.273.42.27091

3949 Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M, Kanno T, Murakami A, Tsuda E, Morinaga T, Higashio K. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology. 1998 139(3):1329-37 PubMed ID: 9492069 DOI: 10.1210/endo.139.3.5837

3950 Yamaguchi T, Chattopadhyay N, Kifor O, Brown EM. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology 1998 139(8):3561-8 PubMed ID: 9681508 DOI: 10.1210/endo.139.8.6163

3951 Harada H, Kuboi Y, Miki R, Honda C, Masushige S, Nakatsuka M, Koga Y, Kato S. Cloning of rabbit TR4 and its bone cell-specific activity to suppress estrogen receptor-mediated transactivation. Endocrinology 1998 139(1):204-12 PubMed ID: 9421416 DOI: 10.1210/endo.139.1.5682

9167 K N Weilbaecher, C L Hershey, C M Takemoto, M A Horstmann, T J Hemesath, A H Tashjian, D E Fisher Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3 J Exp Med 1998 187 (5), 775-85 PubMed ID: 9480987 DOI: 10.1084/jem.187.5.775

13808 Ragab AA, Lavish SA, Banks MA, Goldberg VM, Greenfield EM. Osteoclast differentiation requires ascorbic acid J Bone Miner Res 1998 13(6):970-7 PubMed ID: 9626628 DOI: 10.1359/jbmr.1998.13.6.970

15428 Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 1998 93(2):165-76 PubMed ID: 9568710 DOI: 10.1016/s0092-8674(00)81569-x

16637 Yamaguchi K, Kinosaki M, Goto M, Kobayashi F, Tsuda E, Morinaga T, Higashio K. Characterization of structural domains of human osteoclastogenesis inhibitory factor. J Biol Chem 1998 273:5117-23 PubMed ID: 9478964 DOI: 10.1074/jbc.273.9.5117

2997 Shibata T, Sakai H, Nakamura F, Shioi A, Kuno M Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts. J Membr Biol 1997 158:59-67 PubMed ID: 9211721 DOI: 10.1007/s002329900243

3938 Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997 234(1):137-42 PubMed ID: 9168977 DOI: 10.1006/bbrc.1997.6603

3939 Natsume T, Tomita S, Iemura S, Kinto N, Yamaguchi A, Ueno N. Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4. J Biol Chem 1997 272(17):11535-40 PubMed ID: 9111068 DOI: 10.1074/jbc.272.17.11535

1600 Quinn JM, Sabokbar A, Denne M, de Vernejoul MC, McGee JO, Athanasou NA. Inhibitory and stimulatory effects of prostaglandins on osteoclast differentiation Calcif Tissue Int 1997 60(1):63-70 PubMed ID: 9030482 DOI: 10.1007/s002239900187

2065 Jimi E, Shuto T, Ikebe T, Jingushi S, Hirata M, Koga T Basic fibroblast growth factor inhibits osteoclast-like cell formation. J Cell Physiol 1996 168:395-402 PubMed ID: 8707875 DOI: 10.1002/(SICI)1097-4652(199608)168:2<395::AID-JCP18>3.0.CO;2-2

4868 Romas E, Udagawa N, Zhou H, Tamura T, Saito M, Taga T, Hilton DJ, Suda T, Ng KW, Martin TJ. The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J Exp Med 1996 183(6):2581-91 PubMed ID: 8676079 DOI: 10.1084/jem.183.6.2581

3926 Jimi E, Nakamura I, Amano H, Taguchi Y, Tsurukai T, Tamura M, Takahashi N, Suda T. Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology. 1996 137(8):2187-90 PubMed ID: 8754795 DOI: 10.1210/endo.137.8.8754795

3927 Yamaguchi 1, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, Rosen V, Yoshiki S. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun 1996 220(2):366-71 PubMed ID: 8645311 DOI: 10.1006/bbrc.1996.0411

17218 Fujikawa Y, Quinn JM, Sabokbar A, McGee JO, Athanasou NA. The human osteoclast precursor circulates in the monocyte fraction Endocrinology 1996 137(9):4058-60 PubMed ID: 8756585 DOI: 10.1210/endo.137.9.8756585

2064 Jimi E, Shuto T, Koga T Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells. Endocrinology 1995 136:808-11 PubMed ID: 7835314 DOI: 10.1210/endo.136.2.7835314

3975 Lacey DL, Erdmann JM, Teitelbaum SL, Tan HL, Ohara J, Shioi A. Interleukin 4, interferon-gamma, and prostaglandin E impact the osteoclastic cell-forming potential of murine bone marrow macrophages Endocrinology 1995 2367-76 PubMed ID: 7750457 DOI: 10.1210/endo.136.6.7750457

3079 Shuto T, Jimi E, Kukita T, Hirata M, Koga T Granulocyte-macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures. Endocrinology 1994 134:831-7 PubMed ID: 8299579 DOI: 10.1210/endo.134.2.8299579

10123 Baskin LS, Duckett JW. Dorsal tunica albuginea plication for hypospadias curvature. J. Urol. 1994 151:1668-71 PubMed ID: 8189595 DOI: 10.1016/s0022-5347(17)35341-7

15411 Quinn JM, McGee JO, Athanasou NA. Cellular and hormonal factors influencing monocyte differentiation to osteoclastic bone-resorbing cells Endocrinology 1994 134(6):2416-23 PubMed ID: 8194468 DOI: 10.1210/endo.134.6.8194468

1513 Flanagan, A M, Horton, M A, Dorey, E L, Collins, D A, Evely, R S, Moseley, J M, Firkin, F C, Chambers, T J, Helfrich, M H, Martin, T J An assessment of the ability of human bone marrow cultures to generate osteoclasts. Int J Exp Pathol 1992 73:387-401 PubMed ID: 1320395

1512 Athanasou, N A, Quinn, J M Human tumour-associated macrophages are capable of bone resorption. Br J Cancer 1992 65:523-6 PubMed ID: 1562461 DOI: 10.1038/bjc.1992.108

1515 Kerby, J A, Hattersley G, Collins, D A, Chambers, T J Derivation of osteoclasts from hematopoietic colony-forming cells in culture. J Bone Miner Res 1992 7:353-62 PubMed ID: 1585838 DOI: 10.1002/jbmr.5650070316

10334 J Quinn, C Joyner, J T Triffitt, N A Athanasou Polymethylmethacrylate-induced Inflammatory Macrophages Resorb Bone J Bone Joint Surg Br 1992 74(5):652-8 PubMed ID: 1527108 DOI: 10.1302/0301-620X.74B5.1527108

1514 Shioi A, Teitelbaum, S L, Ross, F P, Welgus, H G, Suzuki H, Ohara J, Lacey, D L Interleukin 4 Inhibits Murine Osteoclast Formation In Vitro J Cell Biol 1991 47:272-277 PubMed ID: 1665152 DOI: 10.1002/jcb.240470313

1431 Hong, M H, Jin, C H, Sato T, Ishimi Y, Abe E, Suda T Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells. Endocrinology 1991 129:2774-9 PubMed ID: 1935807 DOI: 10.1210/endo-129-5-2774

1382 Sato T, Hong, M H, Jin, C H, Ishimi Y, Udagawa N, Shinki T, Abe E, Suda T The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3. FEBS Lett 1991 285:21-4 PubMed ID: 2065778 DOI: 10.1016/0014-5793(91)80715-f

1330 Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin, T J, Suda T Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A 1990 87:7260-4 PubMed ID: 2169622 DOI: 10.1073/pnas.87.18.7260

1327 Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989 125:1805-13 PubMed ID: 2676473 DOI: 10.1210/endo-125-4-1805