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Cell No. : Cell Name
RCB0224 : ST2  update : 2023/11/20
CommentBone marrow stroma cell-derived
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Nishikawa, Shin-ichi
Originator Nishikawa, Shin-ichi
Year of deposit 1987
Animal _mouse < Mammals
Tissue bone marrow
Classification other
History Nishikawa(Kumamoto Univ.)
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_2205
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Chromosome mode 70-80(50) : /74(5),75(5),76(6),77(11),78(12)/
deposit info
lot info
Reference information Reference 11
User's Publication 335

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2436  Nishikawa S, Ogawa M, Nishikawa S, Kunisada T, Kodama H.  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation  Eur J Immunol  1998  18(11):1767-71  PubMed ID: 3264531   DOI: 10.1002/eji.1830181117
8597  P A Welch, P D Burrows, A Namen, S Gillis, M D Cooper  Bone Marrow Stromal Cells and interleukin-7 Induce Coordinate Expression of the BP-1/6C3 Antigen and pre-B Cell Growth  Int Immunol  1990  2 (8), 697-705   PubMed ID: 2083232   DOI: 10.1093/intimm/2.8.697
2437  Hayashi S, Kunisada T, Ogawa M, Sudo T, Kodama H, Suda T, Nishikawa S, Nishikawa S.  Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules  J Exp Med  1990  171(5):1683-95  PubMed ID: 2332734   DOI: 10.1084/jem.171.5.1683
171  Naito M, Takahashi K, Nishikawa S.  Development, differentiation, and maturation of macrophages in the fetal mouse liver  J Leukoc Biol  1990  48(1):27-37  PubMed ID: 2358750   DOI: 10.1002/jlb.48.1.27
173  Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S.  The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene  Nature  1990  345(6274):442-4  PubMed ID: 2188141   DOI: 10.1038/345442a0
1987  Tominaga A, Mita S, Kikuchi Y, Hitoshi Y, Takatsu K, Nishikawa S, Ogawa M  Establishment of IL-5-dependent early B cell lines by long-term bone marrow cultures.  Growth Factors  1989  1:135-46  PubMed ID: 2624778   DOI: 10.3109/08977198909029123
2570  Sudo T, Ito M, Ogawa Y, Iizuka M, Kodama H, Kunisada T, Hayashi S, Ogawa M, Sakai K, Nishikawa S  Interleukin 7 production and function in stromal cell-dependent B cell development.  J Exp Med  1989  170:333-8  PubMed ID: 2787384   DOI: 10.1084/jem.170.1.333
172  Naito M, Yamamura F, Nishikawa S, Takahashi K.  Development, differentiation, and maturation of fetal mouse yolk sac macrophages in cultures  J Leukoc Biol  1989  46(1):1-10  PubMed ID: 2732624   DOI: 10.1002/jlb.46.1.1
174  Nishikawa S, Hayashi S, Nishikawa S, Ogawa M, Kunisada T, Sudo T, Kodama H, Suda T.  Defect of scid mouse revealed in in vitro culture systems  Curr Top Microbiol Immunol  1989  152:39-46  PubMed ID: 2805796   DOI: 10.1007/978-3-642-74974-2_6
175  Nishikawa SI, Hayashi SI, Ogawa M, Kunisada T, Nishikawa S, Sudo T, Nakauchi H, Suda T.  Control of cell growth and differentiation during early B-cell development by stromal cell molecules  Cold Spring Harb Symp Quant Biol  1989  54 Pt 1:171-4  PubMed ID: 2639751   DOI: 10.1101/sqb.1989.054.01.021
965  Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K, Nishikawa S  B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.  EMBO J  1988  7:1337-43  PubMed ID: 3261687   DOI: 10.1002/j.1460-2075.1988.tb02949.x

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User's Publication
21637  Crawford M, Barr K, Dagnino L.  Analysis of Proliferation, Apoptosis, and Motility in Mouse Embryonic Melanocytic Precursor Cells.  Methods Mol Biol  2024    PubMed ID: 38441720   DOI: 10.1007/7651_2024_528
21648  Yamamoto M, Shibata Y, Ito Y, Fukui M, Kioka H, Shoji Y, Kitao T, Shirahase H, Hinoi E.  Osteoblastgenic and Osteogenic Effects of KY-273 with CDK8/19 Inhibitory Activity in Bone Marrow Mesenchymal Stem Cells and Female Rats.  Biol Pharm Bull  2024  47(3):669-679  PubMed ID: 38508765   DOI: 10.1248/bpb.b23-00834
21678  Takeda T, Tsubaki M, Genno S, Tomita K, Nishida S.  RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway.  Exp Cell Res  2024  436(2):113978  PubMed ID: 38382805   DOI: 10.1016/j.yexcr.2024.113978
17544  Shao F, Panahipour L, Gruber R.  Flavonoids from Dalbergia cochinchinensis: Impact on osteoclastogenesis  J Dent Sci  2023  18(1):112-119  PubMed ID: 36643234   DOI: 10.1016/j.jds.2022.06.026
17545  Mizukami Y, Kawao N, Takafuji Y, Ohira T, Okada K, Jo JI, Tabata Y, Kaji H.  Matrix vesicles promote bone repair after a femoral bone defect in mice  PLoS One  2023  18(4):e0284258  PubMed ID: 37027385   DOI: 10.1371/journal.pone.0284258
17750  Kitazawa S, Haraguchi R, Takaoka Y, Kitazawa R.  In situ sequence-specific visualization of single methylated cytosine on tissue sections using ICON probe and rolling-circle amplification  Histochem Cell Biol  2023  159(3):263-273  PubMed ID: 36418613   DOI: 10.1007/s00418-022-02165-2
19567  Yoshimasa Takafuji, Naoyuki Kawao, Takashi Ohira, Yuya Mizukami, Kiyotaka Okada, Jun-Ichiro Jo, Yasuhiko Tabata, Hiroshi Kaji  Extracellular vesicles secreted from mouse muscle cells improve delayed bone repair in diabetic mice  Endocrine Journal  2023  70:161-171    DOI: 10.1507/endocrj.ej22-0340
19614  Omori K, Otani S, Date Y, Ueno T, Ito T, Umeda M, Ito K.  C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development  Oncogene  2023  42(33):2485-2494  PubMed ID: 37402881   DOI: 10.1038/s41388-023-02761-z
19639  Verlinden L, Doms S, Janssens I, Meyer MB, Pike JW, Carmeliet G, Verstuyf A.  Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice  Front Endocrinol (Lausanne)  2023  14:1223021  PubMed ID: 37600714   DOI: 10.3389/fendo.2023.1223021
19734  Yamamoto M, Ito Y, Fukui M, Otake K, Shoji Y, Kitao T, Shirahase H, Hinoi E.  Osteogenic Effects of KY-054, a Novel Coumarin Derivative on Femur Cortical Bone in Ovariectomized Female Rats  Biol Pharm Bull  2023  1435-1443  PubMed ID: 37779045   DOI: 10.1248/bpb.b23-00324
19937  Seong CH, Chiba N, Fredy M, Kusuyama J, Ishihata K, Kibe T, Amir MS, Tada R, Ohnishi T, Nakamura N, Matsuguchi T.  Early induction of Hes1 by bone morphogenetic protein 9 plays a regulatory role in osteoblastic differentiation of a mesenchymal stem cell line  J Cell Biochem  2023  124(9):1366-1378  PubMed ID: 37565579   DOI: 10.1002/jcb.30452
19945  Ana Flávia Piquera Santos, Lara Cristina Cunha Cervantes, Roberta Okamoto, Antonio Carlos Guastaldi, Thallita Pereira Queiroz, Layla Panahipour, Reinhard Gruber, Francisley Ávila Souza  Interleukin-6 Expression of Osteogenic Cell Lines Grown on Laser-Treated and Hydroxyapatite-Coated Titanium Discs  Applied Sciences  2023  13:12646    DOI: 10.3390/app132312646
21006  Hatori T, Maeda T, Suzuki A, Takahashi K, Kato Y.  SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis.  Mol Med Rep  2023  27(2)  PubMed ID: 36633137   DOI: 10.3892/mmr.2023.12937
21086  Kargarpour Z, Panahipour L, Mildner M, Miron RJ, Gruber R.  Lipids of Platelet-Rich Fibrin Reduce the Inflammatory Response in Mesenchymal Cells and Macrophages.  Cells  2023  12(4)  PubMed ID: 36831301   DOI: 10.3390/cells12040634
21400  Crawford M, Barr K, Dagnino L.  Isolation, Purification, and Culture of Embryonic Melanoblasts from Green Fluorescent Protein-expressing Reporter Mice.  Bio Protoc  2023  13(17):e4805  PubMed ID: 37719067   DOI: 10.21769/BioProtoc.4805
21479  Uehara N, Shibusawa N, Mikami Y, Kyumoto-Nakamura Y, Sonoda S, Kato H, Yamaza T, Kukita T.  Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling.  Arch Biochem Biophys  2023  750:109821  PubMed ID: 37979903   DOI: 10.1016/
17599  Panahipour L, Sordi MB, Kargarpour Z, Gruber R.  TGF-β Signalling Mediates the Anti-Inflammatory Activity of Enamel Matrix Derivative In Vitro  Int J Mol Sci  2022  23(17):9778  PubMed ID: 36077174   DOI: 10.3390/ijms23179778
17606  Layla Panahipour, Anes Omerbasic, Azarakhsh Oladzad Abbasabadi, Jila Nasirzade, Zahra Kargarpour, Reinhard Gruber  Anti-Inflammatory Activity of a Demineralized Bone Matrix: An In Vitro Pilot Study  Applied Sciences  2022  12:876    DOI: 10.3390/app12020876
17612  Tanaka T, Takahashi A, Kobayashi Y, Saito M, Xiaolong S, Jingquan C, Ito Y, Kato T, Ochi H, Sato S, Yoshii T, Okawa A, Carlsson P, Inose H.  Foxf2 represses bone formation via Wnt2b/β-catenin signaling  Exp Mol Med  2022  54(6):753-764  PubMed ID: 35668101   DOI: 10.1038/s12276-022-00779-z
17747  Park JW, Seo JH, Lee HJ.  Enhanced osteogenic differentiation of mesenchymal stem cells by surface lithium modification in a sandblasted/acid-etched titanium implant  J Biomater Appl  2022  37(3):447-458  PubMed ID: 35594165   DOI: 10.1177/08853282221104242
20500  Negishi T, Mihara N, Chiba T, D'Armiento J, Chada K, Maeda M, Igarashi M, Imai K.  High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development.  Biochem Biophys Res Commun  2022  590:68-74  PubMed ID: 34973532   DOI: 10.1016/j.bbrc.2021.12.093
20580  Inoue M, Nagai-Yoshioka Y, Yamasaki R, Kawamoto T, Nishihara T, Ariyoshi W.  Mechanisms involved in suppression of osteoclast supportive activity by transforming growth factor-β1 via the ubiquitin-proteasome system.  PLoS One  2022  17(2):e0262612  PubMed ID: 35196318   DOI: 10.1371/journal.pone.0262612
16338  Gámez B, Morris EV, Olechnowicz SWZ, Webb S, Edwards JR, Sowman A, Turner CJ, Edwards CM.  The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo  Transl Oncol  2022  15(1):101301  PubMed ID: 34890968   DOI: 10.1016/j.tranon.2021.101301
16515  Sordi MB, Cabral da Cruz AC, Panahipour L, Gruber R.  Enamel Matrix Derivative Decreases Pyroptosis-Related Genes in Macrophages  Int J Mol Sci  2022  23(9):5078  PubMed ID: 35563469   DOI: 10.3390/ijms23095078
20671  Chen JR, Lazarenko OP, Blackburn ML, Chen JF, Randolph CE, Zabaleta J, Schroder K, Pedersen KB, Ronis MJJ.  Nox4 expression in osteo-progenitors controls bone development in mice during early life.  Commun Biol  2022  5(1):583  PubMed ID: 35701603   DOI: 10.1038/s42003-022-03544-0
16842  Phillips E, Ahmad N, Sun L, Iben J, Walkey CJ, Rusin A, Yuen T, Rosen CJ, Willis IM, Zaidi M, Johnson DL.  MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass  Elife  2022  11:e74740  PubMed ID: 35611941   DOI: 10.7554/eLife.74740
20928  Yu F, Li F, Yu P, Zhou B, Ye L.  Identification and characterization of NFATc1+ skeletal stem cells in bone regeneration.  Cell Rep  2022  41(6):111599  PubMed ID: 36351390   DOI: 10.1016/j.celrep.2022.111599
17334  Panahipour L, Abbasabadi AO, Kaiser V, Sordi MB, Kargarpour Z, Gruber R.  Damaged Mesenchymal Cells Dampen the Inflammatory Response of Macrophages and the Formation of Osteoclasts  J Clin Med  2022  11(14):4061  PubMed ID: 35887825   DOI: 10.3390/jcm11144061
21149  Panahipour L, Cervantes LCC, Oladzad Abbasabadi A, Sordi MB, Kargarpour Z, Gruber R.  Blocking of Caspases Exerts Anti-Inflammatory Effects on Periodontal Cells.  Life (Basel)  2022  12(7)  PubMed ID: 35888133   DOI: 10.3390/life12071045
13190  Parisi L, Buser D, Chappuis V, Asparuhova MB.  Cellular responses to deproteinized bovine bone mineral biofunctionalized with bone-conditioned medium.  Clin Oral Investig  2021  25(4):2159-2173  PubMed ID: 32870390   DOI: 10.1007/s00784-020-03528-6
13394  Tabuchi Y, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Hirayama J, Hoshi N, Mochizuki T.  Genetic response to low‑intensity ultrasound on mouse ST2 bone marrow stromal cells.  Mol Med Rep  2021    PubMed ID: 33398373   DOI: 10.3892/mmr.2020.11812
20134  Hariri H, Addison WN, St-Arnaud R.  Ubiquitin specific peptidase Usp53 regulates osteoblast versus adipocyte lineage commitment.  Sci Rep  2021  11(1):8418  PubMed ID: 33875709   DOI: 10.1038/s41598-021-87608-x
20179  Ito Y, Yamamoto M, Furukawa S, Fukui M, Morishita K, Kitao T, Shirahase H.  Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats.  Biol Pharm Bull  2021  44(5):659-668  PubMed ID: 33952822   DOI: 10.1248/bpb.b20-01002
14506  Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H.  Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells  BMC Musculoskelet Disord  2021  22(1):398  PubMed ID: 33910546   DOI: 10.1186/s12891-021-04278-6
14509  Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H.  Serpinb1a suppresses osteoclast formation  Biochem Biophys Rep  2021  26:101004  PubMed ID: 33997318   DOI: 10.1016/j.bbrep.2021.101004
14783  Yu J, Choi S, Park A, Do J, Nam D, Kim Y, Noh J, Lee KY, Maeng CH, Park KS.  Bone Marrow Homeostasis Is Impaired via JAK/STAT and Glucocorticoid Signaling in Cancer Cachexia Model  Cancers (Basel)  2021  13(5):1059  PubMed ID: 33801569   DOI: 10.3390/cancers13051059
16332  Lin Z, Nica C, Sculean A, Asparuhova MB.  Positive Effects of Three-Dimensional Collagen-Based Matrices on the Behavior of Osteoprogenitors  Front Bioeng Biotechnol  2021  9:708830  PubMed ID: 34368101   DOI: 10.3389/fbioe.2021.708830
16417  Kota SK, Lim ZW, Kota SB.  Elavl1 Impacts Osteogenic Differentiation and mRNA Levels of Genes Involved in ECM Organization  Front Cell Dev Biol  2021  9:606971  PubMed ID: 33614643   DOI: 10.3389/fcell.2021.606971
16795  Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R.  Platelet-Rich Fibrin Decreases the Inflammatory Response of Mesenchymal Cells  Int J Mol Sci  2021  22(21):11333  PubMed ID: 34768764   DOI: 10.3390/ijms222111333
17746  Nam D, Park A, Dubon MJ, Yu J, Kim W, Son Y, Park KS.  Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli  Int J Mol Sci  2020  21(22):8561  PubMed ID: 33202862   DOI: 10.3390/ijms21228561
17748  Park JW.  Positive regulation of Porphyromonas gingivalis lipopolysaccharide-stimulated osteoblast functions by strontium modification of an SLA titanium implant surface  J Biomater Appl  2020  34(6):802-811  PubMed ID: 31558092   DOI: 10.1177/0885328219878836
18711  Yamashita-Sugahara Y, Tokuzawa Y, Nakachi Y, Kanesaki-Yatsuka Y, Matsumoto M, Mizuno Y, Okazaki Y.  Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis  J Biol Chem  2020  295(15):5176  PubMed ID: 32277067   DOI: 10.1074/jbc.AAC120.013475
11638  Crawford M, Leclerc V, Barr K, Dagnino L.  Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin.  J. Invest. Dermatol.  2020  140(2):425-434  PubMed ID: 31330146   DOI: 10.1016/j.jid.2019.07.681
11881  Shiraishi N, Masumoto H, Takahashi K, Tenkumo T, Anada T, Suzuki O, Ogawa T, Sasaki K.  Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus.  Dent Mater J  2020  39(1):148-153.  PubMed ID: 31666486   DOI: 10.4012/dmj.2018-376
6952  Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y.  The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.  Commun Biol  2020  ;3(1):30  PubMed ID: 31949279   DOI: 10.1038/s42003-020-0754-2
12006  Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S.  Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 31964526   DOI: 10.1016/j.bbrc.2020.01.065
12040  Tabuchi Y, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Takeuchi SI, Shiiba M, Mochizuki T.  Low-intensity pulsed ultrasound promotes the expression of immediate-early genes in mouse ST2 bone marrow stromal cells.  J Med Ultrason (2001)  2020    PubMed ID: 32026128   DOI: 10.1007/s10396-020-01007-9
12123  Kawao N, Morita H, Iemura S, Ishida M, Kaji H.  Roles of Dkk2 in the Linkage from Muscle to Bone during Mechanical Unloading in Mice.  Int J Mol Sci  2020    PubMed ID: 32268570   DOI: 10.3390/ijms21072547
12200  Tomokazu Ohnishi, Joji Kusuyama, Kenjiro Bandow, Tetsuya Matsuguchi  Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation  Biochem J   2020  477(10):1795-1811  PubMed ID: 32242617   DOI: 10.1042/BCJ20190888
13151  Cornelis R, Hahne S, Taddeo A, Petkau G, Malko D, Durek P, Thiem M, Heiberger L, Peter L, Mohr E, Klaeden C, Tokoyoda K, Siracusa F, Hoyer BF, Hiepe F, Mashreghi MF, Melchers F, Chang HD, Radbruch A.  Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells.  Cell Rep  2020    PubMed ID: 32755576   DOI: 10.1016/j.celrep.2020.107982
13197  Yahiro Y, Maeda S, Morikawa M, Koinuma D, Jokoji G, Ijuin T, Komiya S, Kageyama R, Miyazono K, Taniguchi N.  BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts.  Bone Res  2020    PubMed ID: 32923015   DOI: 10.1038/s41413-020-00106-0
13352  Ma O, Le T, Talbott G, HoangThao Nguyen T, Ha D, Ho L.  Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity.  Pharmacol Res Perspect  2020    PubMed ID: 33191653   DOI: 10.1002/prp2.670
14181  Tsubaki M, Seki S, Takeda T, Chihara A, Arai Y, Morii Y, Imano M, Satou T, Shimomura K, Nishida S.  The HGF/Met/NF-κB Pathway Regulates RANKL Expression in Osteoblasts and Bone Marrow Stromal Cells  Int J Mol Sci  2020  21(21):7905  PubMed ID: 33114380   DOI: 10.3390/ijms21217905
14295  Takeda T, Tsubak M, Genno S, Matsuda T, Yamamoto Y, Ueda E, Imano M, Satou T, Nishida S.  CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma  J Physiol Pharmacol  2020  71(4)  PubMed ID: 33214335   DOI: 10.26402/jpp.2020.4.02
14500  Asparuhova MB, Chappuis V, Stähli A, Buser D, Sculean A.  Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts  Clin Oral Investig  2020  24(11):3923-3937  PubMed ID: 32236725   DOI: 10.1007/s00784-020-03259-8
11318  Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K.  4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation.  Cytotechnology  2019    PubMed ID: 30474804   DOI: 10.1007/s10616-018-0236-2
11323  Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS.  Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30502084   DOI: 10.1016/j.bbrc.2018.11.154
11366  Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B.  Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling.  J. Cell. Mol. Med.  2019    PubMed ID: 30614617   DOI: 10.1111/jcmm.14126
11439  Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM.  Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.  Cell Metab.  2019    PubMed ID: 30773468   DOI: 10.1016/j.cmet.2019.01.016
11460  Strauss FJ, Di Summa F, Stähli A, Matos L, Vaca F, Schuldt G, Gruber R.  TGF-β activity in acid bone lysate adsorbs to titanium surface.  Clin Implant Dent Relat Res  2019    PubMed ID: 30817088   DOI: 10.1111/cid.12734
11607  Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T.  Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.  Cell. Signal.  2019    PubMed ID: 31228531   DOI: 10.1016/j.cellsig.2019.109345
11659  Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko  3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice  JBMR Plus  2019    PubMed ID: 31667457   DOI: 10.1002/jbm4.10201
11813  Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C.  Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling.  Dev. Cell  2019    PubMed ID: 31543445   DOI: 10.1016/j.devcel.2019.08.013
11856  Hamaya E, Fujisawa T, Tamura M.  Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells.  Int. J. Mol. Med.  2019    PubMed ID: 31638177   DOI: 10.3892/ijmm.2019.4376
11883  Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH.  Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.  FASEB J.  2019    PubMed ID: 31675485   DOI: 10.1096/fj.201802729RRR
6927  Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019.  Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor.  Front Immunol  2019  2019 May 28;10:1164  PubMed ID: 31191537   DOI: 10.3389/fimmu.2019.01164
6935  SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR  An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling  Sains Malaysiana  2019  48(8):1697–1706    DOI: 10.17576/jsm-2019-4808-15
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9336  Ken-ichiro Tanaka, Hiroshi Kaji, Toru Yamaguchi, Ippei Kanazawa, Lucie Canaff, Geoffrey N Hendy, Toshitsugu Sugimoto  Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK-eIF2α-ATF4 Pathway in the Commitment of Myoblastic Into Osteoblastic Cells  Calcif Tissue Int  2014  94(4):454-64  PubMed ID: 24362451   DOI: 10.1007/s00223-013-9828-1
9345  Sunao Takeshita, Toshio Fumoto, Yoshinori Naoe, Kyoji Ikeda  Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL  J Biol Chem  2014  289(24):16699-710  PubMed ID: 24753250   DOI: 10.1074/jbc.M114.547919
9347  Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M Keller, Kenneth M Kozloff, Dana T Aftab, Frauke Schimmoller, Evan T Keller  Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions  Clin Cancer Res  2014  20(3):617-30  PubMed ID: 24097861   DOI: 10.1158/1078-0432.CCR-13-0839
9348  W Ariyoshi, T Okinaga, C B Knudson, W Knudson, T Nishihara  High Molecular Weight Hyaluronic Acid Regulates Osteoclast Formation by Inhibiting Receptor Activator of NF-κB Ligand Through Rho Kinase  Osteoarthritis Cartilage  2014  22(1):111-20  PubMed ID: 24185105   DOI: 10.1016/j.joca.2013.10.013
9350  Masakazu Notsu, Toru Yamaguchi, Kyoko Okazaki, Ken-ichiro Tanaka, Noriko Ogawa, Ippei Kanazawa, Toshitsugu Sugimoto  Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion  Endocrinology  2014  155(7):2402-10  PubMed ID: 24758301   DOI: 10.1210/en.2013-1818
9352  Kiyoshi Mori, Riko Kitazawa, Takeshi Kondo, Michiko Mori, Yasuhiro Hamada, Michiru Nishida, Yasuhiro Minami, Ryuma Haraguchi, Yutaka Takahashi, Sohei Kitazawa  Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene  PLoS One  2014  9(7):e102797  PubMed ID: 25036934   DOI: 10.1371/journal.pone.0102797
9271  Masato Tamura, Maki Uyama, Yuri Sugiyama, Mari Sato  Canonical Wnt Signaling Activates miR-34 Expression During Osteoblastic Differentiation  Mol Med Rep  2013  8(6):1807-11  PubMed ID: 24100761   DOI: 10.3892/mmr.2013.1713
9278  Shingen Nakamura, Hirokazu Miki, Shinsuke Kido, Ayako Nakano, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Keiichiro Watanabe, Takeshi Harada, Shiro Fujii, Kyoko Takeuchi, Kumiko Kagawa, Shuji Ozaki, Toshio Matsumoto, Masahiro Abe  Activating Transcription Factor 4, an ER Stress Mediator, Is Required For, but Excessive ER Stress Suppresses Osteoblastogenesis by Bortezomib  Int J Hematol  2013  98(1):66-73  PubMed ID: 23708974   DOI: 10.1007/s12185-013-1367-z
9289  Yuan Jiang, Jinlu Dai, Honglai Zhang, Joe L Sottnik, Jill M Keller, Katherine J Escott, Hitesh J Sanganee, Zhi Yao, Laurie K McCauley, Evan T Keller  Activation of the Wnt Pathway Through AR79, a GSK3β Inhibitor, Promotes Prostate Cancer Growth in Soft Tissue and Bone  Mol Cancer Res  2013  11(12):1597-610  PubMed ID: 24088787   DOI: 10.1158/1541-7786.MCR-13-0332-T
9292  James J Cody, Angel A Rivera, Gray R Lyons, Sherry W Yang, Minghui Wang, Jason W Ashley, Sreelatha Meleth, Xu Feng, Gene P Siegal, Joanne T Douglas  Expression of Osteoprotegerin From a Replicating Adenovirus Inhibits the Progression of Prostate Cancer Bone Metastases in a Murine Model  Lab Invest  2013  93(3):268-78  PubMed ID: 23358109   DOI: 10.1038/labinvest.2012.179
10992  Yasuhiro Takenaka, Ikuo Inoue, Takanari Nakano, Yuichi Shinoda, Masaaki Ikeda, Takuya Awata, Shigehiro Katayama  A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2  PLoS One  2013  8(6):e65583  PubMed ID: 23840343   DOI: 10.1371/journal.pone.0065583
12708  Kim Y, Kelly OJ, Ilich JZ.  Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth  Lipids  2013  48(8):787-802  PubMed ID: 23757205   DOI: 10.1007/s11745-013-3803-5
7600  Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O.  The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects.  Acta Biomater  2012  8:1190-200  PubMed ID: 22198138   DOI: 10.1016/j.actbio.2011.12.002
7673  Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.  Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction.  Oral Oncol.  2012  48:49-55  PubMed ID: 21945071   DOI: 10.1016/j.oraloncology.2011.08.026
6097  Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A.  CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.  Biochem Biophys Res Commun  2012  424(3):456-61  PubMed ID: 22771802   DOI: 10.1016/j.bbrc.2012.06.132
6102  Tsubaki M, Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S.  Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.  Mol Cell Endocrinol  2012  361(1-2):219-31  PubMed ID: 22579611   DOI: 10.1016/j.mce.2012.05.002
9248  Y Ouji, S Ishizaka, F Nakamura-Uchiyama, M Yoshikawa  In Vitro Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Hair Cell-Like Cells Using Stromal Cell Conditioned Medium  Cell Death Dis  2012  3(5):e314  PubMed ID: 22622133   DOI: 10.1038/cddis.2012.56
9251  Shoichiro Kokabu, Laura Gamer, Karen Cox, Jonathan Lowery, Kunikazu Tsuji, Regina Raz, Aris Economides, Takenobu Katagiri, Vicki Rosen  BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction With Acvr2b  Mol Endocrinol  2012  26(1):87-94  PubMed ID: 22074949   DOI: 10.1210/me.2011-1168
7674  Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P.  Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells.  Cell Prolif.  2011  44:420-7  PubMed ID: 21951285   DOI: 10.1111/j.1365-2184.2011.00769.x
7774  Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K.  Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.  Clin. Exp. Metastasis  2011  28:649-59  PubMed ID: 21688034   DOI: 10.1007/s10585-011-9398-4
7829  Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680   DOI: 10.1007/s12272-011-0316-8
7921  Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A.  Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo.  Exp. Cell Res.  2011  317:1134-46  PubMed ID: 21338601   DOI: 10.1016/j.yexcr.2011.02.008
7943  Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH.  A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.  J. Biol. Chem.  2011  286:12328-39  PubMed ID: 21324897   DOI: 10.1074/jbc.M110.176099
7955  Tamura M, Sato MM, Nashimoto M.  Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.  Int. J. Biochem. Cell Biol.  2011  43:760-7  PubMed ID: 21296678   DOI: 10.1016/j.biocel.2011.01.021
8004  Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M.  Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.  Exp. Cell Res.  2011  317:745-56  PubMed ID: 21211534   DOI: 10.1016/j.yexcr.2010.12.015
8069  Tsuneto M, Yamane T, Hayashi S.  Methods for investigation of osteoclastogenesis using mouse embryonic stem cells.  Methods Mol. Biol.  2011  690:239-53  PubMed ID: 21042997   DOI: 10.1007/978-1-60761-962-8_16
8575  Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa, Hiroshi Suzuki  Rab27a and Rab27b Are Involved in Stimulation-Dependent RANKL Release From Secretory Lysosomes in Osteoblastic Cells  J Bone Miner Res  2011  26(4):689-703   PubMed ID: 20939018   DOI: 10.1002/jbmr.268
8102  Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT.  Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.  Biol. Pharm. Bull.  2010  33:1733-9  PubMed ID: 20930384   DOI: 10.1248/bpb.33.1733
8113  Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A.  Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.  Mol. Cancer Ther.  2010  9:2960-9  PubMed ID: 20858724   DOI: 10.1158/1535-7163.MCT-10-0489
8139  Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.  Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.  Cancer Gene Ther.  2010  17:893-905  PubMed ID: 20798695   DOI: 10.1038/cgt.2010.47
8182  Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K.  Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.  Bone  2010  47:756-65  PubMed ID: 20637325   DOI: 10.1016/j.bone.2010.07.008
8220  Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M.  Cytodifferentiation activity of synthetic human enamel sheath protein peptides.  J. Periodont. Res.  2010  45:643-9  PubMed ID: 20572923   DOI: 10.1111/j.1600-0765.2010.01279.x
8295  Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y.  Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.  PLoS Genet  2010  6(7):e1001019  PubMed ID: 20628571   DOI: 10.1371/journal.pgen.1001019
16149  Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A.  Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells  Am J Pathol  2010  176(2):968-80  PubMed ID: 20035059   DOI: 10.2353/ajpath.2010.090299
8359  Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT.  Inhibitory effect of luteolin on osteoclast differentiation and function.  Cytotechnology  2009  61:125-34  PubMed ID: 20162352   DOI: 10.1007/s10616-010-9253-5
8493  Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA.  Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.  Blood  2009  114:4441-50  PubMed ID: 19762485   DOI: 10.1182/blood-2009-07-233718
8530  Yoshikawa H, Yoshioka K, Nakase T, Itoh K.  Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study.  Clin. Orthop. Relat. Res.  2009  467:3087-95  PubMed ID: 19609629   DOI: 10.1007/s11999-009-0976-6
8570  Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O.  Octacalcium phosphate-precipitated alginate scaffold for bone regeneration.  Tissue Eng Part A  2009  15:3525-35  PubMed ID: 19456237   DOI: 10.1089/ten.TEA.2009.0048
8584  Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T.  Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells.  Anticancer Res.  2009  29:1089-94  PubMed ID: 19414350  
8594  Mogi M, Kondo A.  Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells.  Biochem. Biophys. Res. Commun.  2009  384:82-6  PubMed ID: 19393224   DOI: 10.1016/j.bbrc.2009.04.084
8652  Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.  J. Bone Miner. Metab.  2009  27:355-63  PubMed ID: 19229473   DOI: 10.1007/s00774-009-0040-3
8669  Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O.  The effect of microstructure of octacalcium phosphate on the bone regenerative property.  Tissue Eng Part A  2009  15:1965-73  PubMed ID: 19132890   DOI: 10.1089/ten.tea.2008.0300
8766  Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T.  Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads.  J Biomed Mater Res A  2009  88:599-607  PubMed ID: 18314893   DOI: 10.1002/jbm.a.31833
6536  Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T.  Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.  BMC Dev Biol  2009  9:70  PubMed ID: 20025746   DOI: 10.1186/1471-213X-9-70
8180  Kim CH, Kim KH, Jacobs CR.  Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells.  BMC Musculoskelet Disord  2009  10:109  PubMed ID: 19728893   DOI: 10.1186/1471-2474-10-109
8183  Nose M, Yamazaki H, Hagino H, Morio Y, Hayashi S, Teshima R.  Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients.  J Bone Miner Metab  2009  27(1):57-65  PubMed ID: 19082778   DOI: 10.1007/s00774-008-0011-0
6530  Anada T, Kumagai T, Honda Y, Masuda T, Kamijo R, Kamakura S, Yoshihara N, Kuriyagawa T, Shimauchi H, Suzuki O.  Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells.  Tissue Eng Part A  2008  14(6):965-78  PubMed ID: 19230123   DOI: 10.1089/ten.tea.2007.0339
7863  Maehira F1, Iinuma Y, Eguchi Y, Miyagi I, Teruya S.  Effects of soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice.  J Bone Miner Metab  2008  26(5):446-55  PubMed ID: 18758902   DOI: 10.1007/s00774-007-0845-x
7919  Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K.  Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells.  J Bone Miner Metab  2008  26(2):152-8  PubMed ID: 18301971   DOI: 10.1007/s00774-007-0803-7
7920  Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y.  Effects of alkylphenols on bone metabolism in vivo and in vitro.  Toxicol Lett  2008  181(1):13-8  PubMed ID: 18621119   DOI: 10.1016/j.toxlet.2008.06.863
7930  You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR.  Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading.  Bone  2008  42(1):172-9  PubMed ID: 17997378   DOI: 10.1016/j.bone.2007.09.047
18620  Notoya M, Arai R, Katafuchi T, Minamino N, Hagiwara H.  A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts  Eur J Pharmacol  2007  560(2-3):234-9  PubMed ID: 17328890   DOI: 10.1016/j.ejphar.2007.01.034
7073  Tsubaki M, Kato C, Manno M, Ogaki M, Satou T, Itoh T, Kusunoki T, Tanimori Y, Fujiwara K, Matsuoka H, Nishida S.  Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways.  Mol Cell Biochem  2007  304(1-2):53-60  PubMed ID: 17549607   DOI: 10.1007/s11010-007-9485-7
7354  Takahashi N, Udagawa N, Kobayashi Y, Suda T.  Generation of osteoclasts in vitro, and assay of osteoclast activity.  Methods Mol Med  2007  135:285-301  PubMed ID: 17951666   DOI: 10.1007/978-1-59745-401-8_18
7383  Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B.  Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.  J Cell Biochem  2007  102(6):1458-71  PubMed ID: 17486635   DOI: 10.1002/jcb.21366
7386  Amano S, Arai M, Goto S, Togari A.  Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells.  Biochim Biophys Acta  2007  1770(6):966-73  PubMed ID: 17383824   DOI: 10.1016/j.bbagen.2007.02.009
7391  Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y.  Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner.  J Immunol  2007  179(10):6715-24  PubMed ID: 17982061   DOI: 10.4049/jimmunol.179.10.6715
7392  Niikura K, Nakajima S, Takano M, Yamazaki H.  FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.  Bone  2007  40(4):888-94  PubMed ID: 17157574   DOI: 10.1016/j.bone.2006.10.015
13955  Nakagawa K, Imai Y, Ohta Y, Takaoka K.  Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation  Bone  2007  41(4):543-8  PubMed ID: 17681894   DOI: 10.1016/j.bone.2007.06.013
8891  Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N.  Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.  J Biomed Mater Res A  2006  77:507-11  PubMed ID: 16482552   DOI: 10.1002/jbm.a.30661
8913  Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao  Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro  J Hard Tissue Biology  2006  15:27-33    DOI: 10.2485/jhtb.15.27
18628  Kim CH, You L, Yellowley CE, Jacobs CR.  Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling  Bone  2006  39(5):1043-1047  PubMed ID: 16860618   DOI: 10.1016/j.bone.2006.05.017
6151  Nagayoshi K, Ohkawa H, Yorozu K, Higuchi M, Higashi S, Kubota N, Fukui H, Imai N, Gojo S, Hata J, Kobayashi Y, Umezawa A.  Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification.  J Cell Physiol  2006  208(1):188-94  PubMed ID: 16575918   DOI: 10.1002/jcp.20652
6493  Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H.  Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways.  J Cell Biochem  2006  99(1):196-208  PubMed ID: 16598753   DOI: 10.1002/jcb.20890
6997  Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K.  Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells.  Bone  2006  38(2):206-14  PubMed ID: 16203197   DOI: 10.1016/j.bone.2005.08.006
7012  Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T.  CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.  Mol Cell Biol  2006  26(16):6105-16  PubMed ID: 16880521   DOI: 10.1128/MCB.02429-05
7024  Shin HH, Kim SJ, Kang SY, Lee DS, Choi HS.  Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprotegerin in bone marrow stromal cells.  Bone  2006  39(4):716-23  PubMed ID: 16750437   DOI: 10.1016/j.bone.2006.03.015
12830  Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano A.  Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis  Microbes Infect   2006  8(4):1025-34  PubMed ID: 16476562   DOI: 10.1016/j.micinf.2005.10.021
13953  Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M.  Porcine enamel protein fractions contain transforming growth factor-beta1  J Periodontol  2006  77(10):1688-94  PubMed ID: 17032111   DOI: 10.1902/jop.2006.050352
13957  Suzuki O, Kamakura S, Katagiri T, Nakamura M, Zhao B, Honda Y, Kamijo R.  Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite  Biomaterials  2006  27(13):2671-81  PubMed ID: 16413054   DOI: 10.1016/j.biomaterials.2005.12.004
3294  Deshimaru, Ryota, Ishitani, Ken, Makita, Kazuya, Horiguchi, Fumi, Nozawa, Shiro  Analysis of fatty acid composition in human bone marrow aspirates.  Keio J Med  2005  54:150-5  PubMed ID: 16237277   DOI: 10.2302/kjm.54.150
2879  Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K  Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.  Biochem Biophys Res Commun  2005  328:91-7  PubMed ID: 15670755   DOI: 10.1016/j.bbrc.2004.12.145
3366  Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia  Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.  Am J Physiol Cell Physiol  2005  288:C156-68  PubMed ID: 15342339   DOI: 10.1152/ajpcell.00092.2004
3183  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650   DOI: 10.1128/MCB.25.5.1971-1979.2005
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