CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0224 : ST2]

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13151 Cornelis R, Hahne S, Taddeo A, Petkau G, Malko D, Durek P, Thiem M, Heiberger L, Peter L, Mohr E, Klaeden C, Tokoyoda K, Siracusa F, Hoyer BF, Hiepe F, Mashreghi MF, Melchers F, Chang HD, Radbruch A. Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells. Cell Rep 2020 PubMed ID: 32755576 DOI: 10.1016/j.celrep.2020.107982

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11318 Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation. Cytotechnology 2019 PubMed ID: 30474804 DOI: 10.1007/s10616-018-0236-2

11323 Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30502084 DOI: 10.1016/j.bbrc.2018.11.154

11366 Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B. Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling. J. Cell. Mol. Med. 2019 PubMed ID: 30614617 DOI: 10.1111/jcmm.14126

11439 Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM. Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. Cell Metab. 2019 PubMed ID: 30773468 DOI: 10.1016/j.cmet.2019.01.016

11460 Strauss FJ, Di Summa F, Stähli A, Matos L, Vaca F, Schuldt G, Gruber R. TGF-β activity in acid bone lysate adsorbs to titanium surface. Clin Implant Dent Relat Res 2019 PubMed ID: 30817088 DOI: 10.1111/cid.12734

11607 Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cell. Signal. 2019 PubMed ID: 31228531 DOI: 10.1016/j.cellsig.2019.109345

11659 Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice JBMR Plus 2019 PubMed ID: 31667457 DOI: 10.1002/jbm4.10201

11813 Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C. Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling. Dev. Cell 2019 PubMed ID: 31543445 DOI: 10.1016/j.devcel.2019.08.013

11856 Hamaya E, Fujisawa T, Tamura M. Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells. Int. J. Mol. Med. 2019 PubMed ID: 31638177 DOI: 10.3892/ijmm.2019.4376

11883 Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis. FASEB J. 2019 PubMed ID: 31675485 DOI: 10.1096/fj.201802729RRR

6927 Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019. Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. Front Immunol 2019 2019 May 28;10:1164 PubMed ID: 31191537 DOI: 10.3389/fimmu.2019.01164

6935 SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling Sains Malaysiana 2019 48(8):1697–1706 DOI: 10.17576/jsm-2019-4808-15

9727 Jinlu Dai, June Escara-Wilke, Jill M Keller, Younghun Jung, Russell S Taichman, Kenneth J Pienta, Evan T Keller Primary Prostate Cancer Educates Bone Stroma Through Exosomal Pyruvate Kinase M2 to Promote Bone Metastasis J Exp Med 2019 216(12):2883-2899 PubMed ID: 31548301 DOI: 10.1084/jem.20190158

10553 Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto and Keiichi Sasaki Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant Appl Sci 2019 9(1):172 DOI: 10.3390/app9010172

12590 Mashimo K, Tsubaki M, Takeda T, Asano R, Jinushi M, Imano M, Satou T, Sakaguchi K, Nishida S. RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells Clin Exp Med 2019 19(1):133-141 PubMed ID: 30291461 DOI: 10.1007/s10238-018-0531-4

12591 Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation Biochem Biophys Res Commun 2019 509(2):435-440 PubMed ID: 30594398 DOI: 10.1016/j.bbrc.2018.12.093

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10992 Yasuhiro Takenaka, Ikuo Inoue, Takanari Nakano, Yuichi Shinoda, Masaaki Ikeda, Takuya Awata, Shigehiro Katayama A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2 PLoS One 2013 8(6):e65583 PubMed ID: 23840343 DOI: 10.1371/journal.pone.0065583

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7600 Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, Suzuki O. The effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects. Acta Biomater 2012 8:1190-200 PubMed ID: 22198138 DOI: 10.1016/j.actbio.2011.12.002

7673 Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A. Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction. Oral Oncol. 2012 48:49-55 PubMed ID: 21945071 DOI: 10.1016/j.oraloncology.2011.08.026

6097 Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A. CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction. Biochem Biophys Res Commun 2012 424(3):456-61 PubMed ID: 22771802 DOI: 10.1016/j.bbrc.2012.06.132

6102 Tsubaki M, Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S. Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2. Mol Cell Endocrinol 2012 361(1-2):219-31 PubMed ID: 22579611 DOI: 10.1016/j.mce.2012.05.002

9248 Y Ouji, S Ishizaka, F Nakamura-Uchiyama, M Yoshikawa In Vitro Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Hair Cell-Like Cells Using Stromal Cell Conditioned Medium Cell Death Dis 2012 3(5):e314 PubMed ID: 22622133 DOI: 10.1038/cddis.2012.56

9251 Shoichiro Kokabu, Laura Gamer, Karen Cox, Jonathan Lowery, Kunikazu Tsuji, Regina Raz, Aris Economides, Takenobu Katagiri, Vicki Rosen BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction With Acvr2b Mol Endocrinol 2012 26(1):87-94 PubMed ID: 22074949 DOI: 10.1210/me.2011-1168

7674 Huang H, Zhao N, Xu X, Xu Y, Li S, Zhang J, Yang P. Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells. Cell Prolif. 2011 44:420-7 PubMed ID: 21951285 DOI: 10.1111/j.1365-2184.2011.00769.x

7744 Yoshida K, Higuchi C, Nakura A, Yoshikawa H. Spleen tyrosine kinase suppresses osteoblastic differentiation through MAPK and PKCα. Biochem. Biophys. Res. Commun. 2011 411:774-9 PubMed ID: 21782794 DOI: 10.1016/j.bbrc.2011.07.023

7774 Furugaki K, Moriya Y, Iwai T, Yorozu K, Yanagisawa M, Kondoh K, Fujimoto-Ohuchi K, Mori K. Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292. Clin. Exp. Metastasis 2011 28:649-59 PubMed ID: 21688034 DOI: 10.1007/s10585-011-9398-4

7829 Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S. Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells. Arch. Pharm. Res. 2011 34:469-75 PubMed ID: 21547680 DOI: 10.1007/s12272-011-0316-8

7921 Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan NM, Honami T, Hatakeyama S, Ikeda M, Naomoto Y, Sasaki A. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Exp. Cell Res. 2011 317:1134-46 PubMed ID: 21338601 DOI: 10.1016/j.yexcr.2011.02.008

7943 Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH. A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 2011 286:12328-39 PubMed ID: 21324897 DOI: 10.1074/jbc.M110.176099

7955 Tamura M, Sato MM, Nashimoto M. Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells. Int. J. Biochem. Cell Biol. 2011 43:760-7 PubMed ID: 21296678 DOI: 10.1016/j.biocel.2011.01.021

8004 Taipaleenmaki H, Abdallah BM, AlDahmash A, Saamanen AM, Kassem M. Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations. Exp. Cell Res. 2011 317:745-56 PubMed ID: 21211534 DOI: 10.1016/j.yexcr.2010.12.015

8069 Tsuneto M, Yamane T, Hayashi S. Methods for investigation of osteoclastogenesis using mouse embryonic stem cells. Methods Mol. Biol. 2011 690:239-53 PubMed ID: 21042997 DOI: 10.1007/978-1-60761-962-8_16

8575 Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa, Hiroshi Suzuki Rab27a and Rab27b Are Involved in Stimulation-Dependent RANKL Release From Secretory Lysosomes in Osteoblastic Cells J Bone Miner Res 2011 26(4):689-703 PubMed ID: 20939018 DOI: 10.1002/jbmr.268

8102 Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells. Biol. Pharm. Bull. 2010 33:1733-9 PubMed ID: 20930384 DOI: 10.1248/bpb.33.1733

8113 Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol. Cancer Ther. 2010 9:2960-9 PubMed ID: 20858724 DOI: 10.1158/1535-7163.MCT-10-0489

8139 Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT. Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer. Cancer Gene Ther. 2010 17:893-905 PubMed ID: 20798695 DOI: 10.1038/cgt.2010.47

8182 Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K. Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway. Bone 2010 47:756-65 PubMed ID: 20637325 DOI: 10.1016/j.bone.2010.07.008

8220 Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M. Cytodifferentiation activity of synthetic human enamel sheath protein peptides. J. Periodont. Res. 2010 45:643-9 PubMed ID: 20572923 DOI: 10.1111/j.1600-0765.2010.01279.x

19100 Matsui A, Anada T, Masuda T, Honda Y, Miyatake N, Kawai T, Kamakura S, Echigo S, Suzuki O. Mechanical stress-related calvaria bone augmentation by onlayed octacalcium phosphate-collagen implant Tissue Eng Part A 2010 16(1):139-51 PubMed ID: 19642866 DOI: 10.1089/ten.TEA.2009.0284

19261 Ha H, Lee HY, Lee JH, Jung D, Choi J, Song KY, Jung HJ, Choi JS, Chang SI, Kim C. Formononetin prevents ovariectomy-induced bone loss in rats Arch Pharm Res 2010 33(4):625-32 PubMed ID: 20422373 DOI: 10.1007/s12272-010-0418-8

8295 Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet 2010 6(7):e1001019 PubMed ID: 20628571 DOI: 10.1371/journal.pgen.1001019

16149 Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells Am J Pathol 2010 176(2):968-80 PubMed ID: 20035059 DOI: 10.2353/ajpath.2010.090299

8359 Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology 2009 61:125-34 PubMed ID: 20162352 DOI: 10.1007/s10616-010-9253-5

8493 Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 2009 114:4441-50 PubMed ID: 19762485 DOI: 10.1182/blood-2009-07-233718

8530 Yoshikawa H, Yoshioka K, Nakase T, Itoh K. Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study. Clin. Orthop. Relat. Res. 2009 467:3087-95 PubMed ID: 19609629 DOI: 10.1007/s11999-009-0976-6

8570 Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O. Octacalcium phosphate-precipitated alginate scaffold for bone regeneration. Tissue Eng Part A 2009 15:3525-35 PubMed ID: 19456237 DOI: 10.1089/ten.TEA.2009.0048

8584 Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T. Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. Anticancer Res. 2009 29:1089-94 PubMed ID: 19414350

8594 Mogi M, Kondo A. Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells. Biochem. Biophys. Res. Commun. 2009 384:82-6 PubMed ID: 19393224 DOI: 10.1016/j.bbrc.2009.04.084

8652 Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K. Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing. J. Bone Miner. Metab. 2009 27:355-63 PubMed ID: 19229473 DOI: 10.1007/s00774-009-0040-3

8669 Honda Y, Anada T, Kamakura S, Morimoto S, Kuriyagawa T, Suzuki O. The effect of microstructure of octacalcium phosphate on the bone regenerative property. Tissue Eng Part A 2009 15:1965-73 PubMed ID: 19132890 DOI: 10.1089/ten.tea.2008.0300

8766 Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T. Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads. J Biomed Mater Res A 2009 88:599-607 PubMed ID: 18314893 DOI: 10.1002/jbm.a.31833

6536 Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol 2009 9:70 PubMed ID: 20025746 DOI: 10.1186/1471-213X-9-70

8180 Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells. BMC Musculoskelet Disord 2009 10:109 PubMed ID: 19728893 DOI: 10.1186/1471-2474-10-109

8183 Nose M, Yamazaki H, Hagino H, Morio Y, Hayashi S, Teshima R. Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients. J Bone Miner Metab 2009 27(1):57-65 PubMed ID: 19082778 DOI: 10.1007/s00774-008-0011-0

6530 Anada T, Kumagai T, Honda Y, Masuda T, Kamijo R, Kamakura S, Yoshihara N, Kuriyagawa T, Shimauchi H, Suzuki O. Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells. Tissue Eng Part A 2008 14(6):965-78 PubMed ID: 19230123 DOI: 10.1089/ten.tea.2007.0339

7863 Maehira F1, Iinuma Y, Eguchi Y, Miyagi I, Teruya S. Effects of soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice. J Bone Miner Metab 2008 26(5):446-55 PubMed ID: 18758902 DOI: 10.1007/s00774-007-0845-x

7919 Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K. Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells. J Bone Miner Metab 2008 26(2):152-8 PubMed ID: 18301971 DOI: 10.1007/s00774-007-0803-7

7920 Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y. Effects of alkylphenols on bone metabolism in vivo and in vitro. Toxicol Lett 2008 181(1):13-8 PubMed ID: 18621119 DOI: 10.1016/j.toxlet.2008.06.863

7930 You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 2008 42(1):172-9 PubMed ID: 17997378 DOI: 10.1016/j.bone.2007.09.047

15372 Ishii J, Kitazawa R, Mori K, McHugh KP, Morii E, Kondo T, Kitazawa S. Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF J Cell Biochem 2008 105(3):896-904 PubMed ID: 18759249 DOI: 10.1002/jcb.21886

18620 Notoya M, Arai R, Katafuchi T, Minamino N, Hagiwara H. A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts Eur J Pharmacol 2007 560(2-3):234-9 PubMed ID: 17328890 DOI: 10.1016/j.ejphar.2007.01.034

19404 Kitazawa R, Kitazawa S. Methylation status of a single CpG locus 3 bases upstream of TATA-box of receptor activator of nuclear factor-kappaB ligand (RANKL) gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis Mol Endocrinol 2007 21(1):148-58 PubMed ID: 17008384 DOI: 10.1210/me.2006-0205

7073 Tsubaki M, Kato C, Manno M, Ogaki M, Satou T, Itoh T, Kusunoki T, Tanimori Y, Fujiwara K, Matsuoka H, Nishida S. Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways. Mol Cell Biochem 2007 304(1-2):53-60 PubMed ID: 17549607 DOI: 10.1007/s11010-007-9485-7

7354 Takahashi N, Udagawa N, Kobayashi Y, Suda T. Generation of osteoclasts in vitro, and assay of osteoclast activity. Methods Mol Med 2007 135:285-301 PubMed ID: 17951666 DOI: 10.1007/978-1-59745-401-8_18

7383 Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B. Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem 2007 102(6):1458-71 PubMed ID: 17486635 DOI: 10.1002/jcb.21366

7386 Amano S, Arai M, Goto S, Togari A. Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells. Biochim Biophys Acta 2007 1770(6):966-73 PubMed ID: 17383824 DOI: 10.1016/j.bbagen.2007.02.009

7391 Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y. Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner. J Immunol 2007 179(10):6715-24 PubMed ID: 17982061 DOI: 10.4049/jimmunol.179.10.6715

7392 Niikura K, Nakajima S, Takano M, Yamazaki H. FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats. Bone 2007 40(4):888-94 PubMed ID: 17157574 DOI: 10.1016/j.bone.2006.10.015

13955 Nakagawa K, Imai Y, Ohta Y, Takaoka K. Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation Bone 2007 41(4):543-8 PubMed ID: 17681894 DOI: 10.1016/j.bone.2007.06.013

8891 Tsujigiwa H, Nagatsuka H, Lee YJ, Han PP, Gunduz M, Legeros RZ, Inoue M, Yamada M, Nagai N. Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells. J Biomed Mater Res A 2006 77:507-11 PubMed ID: 16482552 DOI: 10.1002/jbm.a.30661

8913 Hidetsugu Tsujigiwa, Andrea P. Rodriguez, Tohru Takagi, Hu Hai Long, Kan Rui, Zhenfu Lu, Xie Wei Li, Gao Wen-Xin, Jin Tan and Jing Xiao Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro J Hard Tissue Biology 2006 15:27-33 DOI: 10.2485/jhtb.15.27

18628 Kim CH, You L, Yellowley CE, Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling Bone 2006 39(5):1043-1047 PubMed ID: 16860618 DOI: 10.1016/j.bone.2006.05.017

6151 Nagayoshi K, Ohkawa H, Yorozu K, Higuchi M, Higashi S, Kubota N, Fukui H, Imai N, Gojo S, Hata J, Kobayashi Y, Umezawa A. Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification. J Cell Physiol 2006 208(1):188-94 PubMed ID: 16575918 DOI: 10.1002/jcp.20652

6493 Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006 99(1):196-208 PubMed ID: 16598753 DOI: 10.1002/jcb.20890

6997 Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K. Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells. Bone 2006 38(2):206-14 PubMed ID: 16203197 DOI: 10.1016/j.bone.2005.08.006

7012 Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T. CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol 2006 26(16):6105-16 PubMed ID: 16880521 DOI: 10.1128/MCB.02429-05

7024 Shin HH, Kim SJ, Kang SY, Lee DS, Choi HS. Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprotegerin in bone marrow stromal cells. Bone 2006 39(4):716-23 PubMed ID: 16750437 DOI: 10.1016/j.bone.2006.03.015

12830 Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano A. Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis Microbes Infect 2006 8(4):1025-34 PubMed ID: 16476562 DOI: 10.1016/j.micinf.2005.10.021

13953 Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M. Porcine enamel protein fractions contain transforming growth factor-beta1 J Periodontol 2006 77(10):1688-94 PubMed ID: 17032111 DOI: 10.1902/jop.2006.050352

13957 Suzuki O, Kamakura S, Katagiri T, Nakamura M, Zhao B, Honda Y, Kamijo R. Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite Biomaterials 2006 27(13):2671-81 PubMed ID: 16413054 DOI: 10.1016/j.biomaterials.2005.12.004

2300 Rossa C, Ehmann K, Liu M, Patil C, Kirkwood KL. MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells J Interferon Cytokine Res 2006 26(10):719-29 PubMed ID: 17032166 DOI: 10.1089/jir.2006.26.719

3294 Deshimaru, Ryota, Ishitani, Ken, Makita, Kazuya, Horiguchi, Fumi, Nozawa, Shiro Analysis of fatty acid composition in human bone marrow aspirates. Keio J Med 2005 54:150-5 PubMed ID: 16237277 DOI: 10.2302/kjm.54.150

2879 Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. Biochem Biophys Res Commun 2005 328:91-7 PubMed ID: 15670755 DOI: 10.1016/j.bbrc.2004.12.145

3366 Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis. Am J Physiol Cell Physiol 2005 288:C156-68 PubMed ID: 15342339 DOI: 10.1152/ajpcell.00092.2004

3183 Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol 2005 25:1971-9 PubMed ID: 15713650 DOI: 10.1128/MCB.25.5.1971-1979.2005

2843 Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Am J Pathol 2005 166:1817-26 PubMed ID: 15920166 DOI: 10.1016/S0002-9440(10)62491-1

3377 Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res 2005 65:7554-60 PubMed ID: 16140917 DOI: 10.1158/0008-5472.CAN-05-1317

8993 Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N. Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells. J Biomed Mater Res A 2005 75:210-5 PubMed ID: 16059889 DOI: 10.1002/jbm.a.30416

9055 Kandler B, Maitz P, Fischer MB, Watzek G, Gruber R. Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation. Bone 2005 36:671-7 PubMed ID: 15784190 DOI: 10.1016/j.bone.2005.01.015

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6870 Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL. Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone 2005 37(3):313-22 PubMed ID: 16023419 DOI: 10.1016/j.bone.2005.04.040

6877 Liu J, Yang H, Liu W, Cao X, Feng X. Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. J Cell Biochem 2005 96(4):716-27 PubMed ID: 16052479 DOI: 10.1002/jcb.20569

2871 Notoya M, Otsuka E, Yamaguchi A, Hagiwara H Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochem Biophys Res Commun 2004 324:655-60 PubMed ID: 15474477 DOI: 10.1016/j.bbrc.2004.09.101

2910 Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology 2004 145:751-9 PubMed ID: 14563699 DOI: 10.1210/en.2003-0726

2926 French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004 165:855-67 PubMed ID: 15331410 DOI: 10.1016/S0002-9440(10)63348-2

6737 Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H. Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells. Biochem Pharmacol 2004 67(1):119-27 PubMed ID: 14667934 DOI: 10.1016/j.bcp.2003.08.038

6739 Karst M, Gorny G, Galvin RJ, Oursler MJ. Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation. J Cell Physiol 2004 200(1):99-106 PubMed ID: 15137062 DOI: 10.1002/jcp.20036

15606 Gorny G, Shaw A, Oursler MJ. IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro Exp Cell Res 2004 294(1):149-58 PubMed ID: 14980510 DOI: 10.1016/j.yexcr.2003.11.009

16483 Osteopontin as a positive regulator in the osteoclastogenesis of arthritis Biochem Biophys Res Commun 2004 316(3):809-15 PubMed ID: 15033472 DOI: 10.1016/j.bbrc.2004.02.124

2253 Niikura K, Takano M, Sawada M. A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase Br J Pharmacol 2004 142(3):558-66 PubMed ID: 15148249 DOI: 10.1038/sj.bjp.0705812

3059 Tazoe, Michiko, Mogi, Makio, Goto, Shigemi, Togari, Akifumi Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells. Arch Oral Biol 2003 48:615-9 PubMed ID: 12828991 DOI: 10.1016/s0003-9969(03)00100-6

5407 Yamagami H, Nishioka T, Ochiai E, Fukushima K, Nomura M, Kasugai S, Moritani S, Yokogawa K, Miyamoto K. Inhibition of osteoclastogenesis by a phosphodiesterase 4 inhibitor XT-611 through synergistic action with endogenous prostaglandin E2. Biochem Pharmacol 2003 66(5):801-7 PubMed ID: 12948861 DOI: 10.1016/s0006-2952(03)00409-x

4964 Gruber R, Graninger W, Bobacz K, Watzek G, Erlacher L. BMP-6-induced osteogenic differentiation of mesenchymal cell lines is not modulated by sex steroids and resveratrol. Cytokine 2003 23(4-5):133-7 PubMed ID: 12967649 DOI: 10.1016/s1043-4666(03)00223-0

4415 Itoh F, Aoyagi S, Furihata-Komatsu H, Aoki M, Kusama H, Kojima M, Kogo H. Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures. Eur J Pharmacol 2003 477(1):9-16 PubMed ID: 14512092 DOI: 10.1016/j.ejphar.2003.08.011

6629 Takahashi N, Udagawa N, Tanaka S, Suda T. Generating murine osteoclasts from bone marrow. Methods Mol Med 2003 80:129-44 PubMed ID: 12728715 DOI: 10.1385/1-59259-366-6:129

6662 Fratzl-Zelman N, Glantschnig H, Rumpler M, Nader A, Ellinger A, Varga F. The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones. Cell Biol Int 2003 27(6):459-68 PubMed ID: 12798773 DOI: 10.1016/s1065-6995(03)00037-4

6696 Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003 144(2):681-92 PubMed ID: 12538631 DOI: 10.1210/en.2002-220682

6697 Ding J, Nagai K, Woo JT. Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Biosci Biotechnol Biochem 2003 67(2):314-21 PubMed ID: 12728992 DOI: 10.1271/bbb.67.314

6704 Ha H, Ho J, Shin S, Kim H, Koo S, Kim IH, Kim C. Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition. Arch Pharm Res 2003 26(11):929-36 PubMed ID: 14661859 DOI: 10.1007/bf02980202

6707 Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y. Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res 2003 18(2):360-9 PubMed ID: 12568414 DOI: 10.1359/jbmr.2003.18.2.360

15417 Shalhoub V, Grisanti M, Padagas J, Scully S, Rattan A, Qi M, Varnum B, Vezina C, Lacey D, Martin D. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells Crit Rev Eukaryot Gene Expr 2003 13(2-4):89-106 PubMed ID: 14696958 DOI: 10.1615/critreveukaryotgeneexpr.v13.i24.30

16305 Nagano M, Ryu BY, Brinster CJ, Avarbock MR, Brinster RL. Maintenance of mouse male germ line stem cells in vitro Biol Reprod 2003 68(6):2207-14 PubMed ID: 12606373 DOI: 10.1095/biolreprod.102.014050

2518 Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect J Periodontal Res 2003 38(3):333-42 PubMed ID: 12753373 DOI: 10.1034/j.1600-0765.2003.00667.x

2773 Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP). Cell Tissue Res 2002 309:269-79 PubMed ID: 12172786 DOI: 10.1007/s00441-002-0587-y

2546 Kitazawa, Riko, Kitazawa, Sohei Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter. Biochem Biophys Res Commun 2002 290:650-5 PubMed ID: 11785948 DOI: 10.1006/bbrc.2001.6251

3000 Sakuta K, Sakai H, Mori H, Morihata H, Kuno M Na+ dependence of extracellular Ca2+-sensing mechanisms leading to activation of an outwardly rectifying Cl- channel in murine osteoclasts. Bone 2002 31:374-80 PubMed ID: 12231409 DOI: 10.1016/s8756-3282(02)00838-4

2999 Sakuta, Koichi, Morihata, Hirokazu, Mori, Hiroyuki, Sakai, Hiromu, Kuno, Miyuki Cell swelling as an intermediate signal leading to activation of a Cl- channel in extracellular calcium-sensing of murine osteoclasts. Osaka City Med J 2002 48:29-38 PubMed ID: 12375695

3582 Miura M, Tanaka K, Komatsu Y, Suda M, Yasoda A, Sakuma Y, Ozasa A, Nakao K. A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation. Biochem Biophys Res Commun 2002 291(4):987-94 PubMed ID: 11866463 DOI: 10.1006/bbrc.2002.6561

6673 Kuriyama K, Higuchi C, Tanaka K, Yoshikawa H, Itoh K. A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein-2-induced bone formation in vivo. Biochem Biophys Res Commun 2002 299(5):903-9 PubMed ID: 12470665 DOI: 10.1016/s0006-291x(02)02754-7

6675 Tsutsumimoto T, Wakabayashi S, Kinoshita T, Horiuchi H, Takaoka K. A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cells. Bone 2002 31(3):396-401 PubMed ID: 12231412 DOI: 10.1016/s8756-3282(02)00839-6

6679 Hinoi E, Fujimori S, Takemori A, Yoneda Y. Cell death by pyruvate deficiency in proliferative cultured calvarial osteoblasts. Biochem Biophys Res Commun 2002 294(5):1177-83 PubMed ID: 12074601 DOI: 10.1016/S0006-291X(02)00578-8

6684 Kitazawa S, Kitazawa R. Epigenetic control of mouse receptor activator of NF-kappa B ligand gene expression. Biochem Biophys Res Commun 2002 293(1):126-31 PubMed ID: 12054573 DOI: 10.1016/S0006-291X(02)00189-4

6692 Wakabayashi S, Tsutsumimoto T, Kawasaki S, Kinoshita T, Horiuchi H, Takaoka K. Involvement of phosphodiesterase isozymes in osteoblastic differentiation. J Bone Miner Res 2002 17(2):249-56 PubMed ID: 11811555 DOI: 10.1359/jbmr.2002.17.2.249

6693 Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T. Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem 2002 277(50):49011-8 PubMed ID: 12384500 DOI: 10.1074/jbc.M207804200

6698 Goseki-Sone M, Yamada A, Hamatani R, Mizoi L, Iimura T, Ezawa I. Phosphate depletion enhances bone morphogenetic protein-4 gene expression in a cultured mouse marrow stromal cell line ST2. Biochem Biophys Res Commun 2002 ;299(3):395-9 PubMed ID: 12445813 DOI: 10.1016/s0006-291x(02)02646-3

6699 Tang L, Ebara S, Kawasaki S, Wakabayashi S, Nikaido T, Takaoka K. FK506 enhanced osteoblastic differentiation in mesenchymal cells. Cell Biol Int 2002 26(1):75-84 PubMed ID: 11779223 DOI: 10.1006/cbir.2001.0812

6700 Mikuni-Takagaki Y, Naruse K, Azuma Y, Miyauchi A. The role of calcium channels in osteocyte function. J Musculoskelet Neuronal Interact 2002 2(3):252-5 PubMed ID: 15758446

6702 Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology 2002 143(6):2349-56 PubMed ID: 12021200 DOI: 10.1210/endo.143.6.8854

17294 Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway J Biol Chem 2002 277(16):14221-6 PubMed ID: 11827970 DOI: 10.1074/jbc.M111551200

17296 Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo J Clin Endocrinol Metab 2002 87(9):4273-9 PubMed ID: 12213884 DOI: 10.1210/jc.2002-020656

17299 Ishida A, Fujita N, Kitazawa R, Tsuruo T. Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone J Biol Chem 2002 277(29):26217-24 PubMed ID: 12011070 DOI: 10.1074/jbc.M111093200

2771 Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers. J Bone Miner Metab 2001 19:220-7 PubMed ID: 11448014 DOI: 10.1007/s007740170024

2772 Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines. Cell Tissue Res 2001 304:351-9 PubMed ID: 11456411 DOI: 10.1007/s004410100347

6657 Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 2001 166(5):3574-9 PubMed ID: 11207318 DOI: 10.4049/jimmunol.166.5.3574

6663 Yamagishi T, Otsuka E, Hagiwara H. Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis. Endocrinology 2001 142(8):3632-7 PubMed ID: 11459812 DOI: 10.1210/endo.142.8.8310

6666 Ding J, Woo JT, Nagai K. The effects of retinoic acid on reversing the adipocyte differentiation into an osteoblastic tendency in ST2 cells, a murine bone marrow-derived stromal cell line. Cytotechnology 2001 36(1-3):125-36 PubMed ID: 19003323 DOI: 10.1023/A:1014056012278

16947 Fan X, Fan D, Gewant H, Royce CL, Nanes MS, Rubin J. Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells Am J Physiol Endocrinol Metab 2001 280(1):E103-11. PubMed ID: 11120664 DOI: 10.1152/ajpendo.2001.280.1.E103

16962 Yano K, Shibata O, Mizuno A, Kobayashi F, Higashio K, Morinaga T, Tsuda E. Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy Biochem Biophys Res Commun 2001 288(1):217-24 PubMed ID: 11594776 DOI: 10.1006/bbrc.2001.5745

2430 Otsuka E, Kato Y, Hirose S, Hagiwara H Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 2000 141:3006-11 PubMed ID: 10919289 DOI: 10.1210/endo.141.8.7597

5400 Kawaguchi N, Noda M. Mitf is expressed in osteoclast progenitors in vitro. Exp Cell Res 2000 260(2):284-91 PubMed ID: 11035923 DOI: 10.1006/excr.2000.5020

3984 Naruse K, Mikuni-Takagaki Y, Azuma Y, Ito M, Oota T, Kameyama K, Itoman M. Anabolic response of mouse bone-marrow-derived stromal cell clone ST2 cells to low-intensity pulsed ultrasound. Biochem Biophys Res Commun 2000 268(1):216-20 PubMed ID: 10652238 DOI: 10.1006/bbrc.2000.2094

3987 Gruber R, Nothegger G, Ho GM, Willheim M, Peterlik M. Differential stimulation by PGE(2) and calcemic hormones of IL-6 in stromal/osteoblastic cells. Biochem Biophys Res Commun 2000 270(3):1080-5 PubMed ID: 10772953 DOI: 10.1006/bbrc.2000.2573

3988 Koyama A, Otsuka E, Inoue A, Hirose S, Hagiwara H. Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2). Eur J Pharmacol 2000 391(3):225-31 PubMed ID: 10729362 DOI: 10.1016/s0014-2999(00)00100-x

3990 Takami M, Takahashi N, Udagawa N, Miyaura C, Suda K, Woo JT, Martin TJ, Nagai K, Suda T. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 2000 141(12):4711-9 PubMed ID: 11108286 DOI: 10.1210/endo.141.12.7852

3996 Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone 2000 27(6):769-76 PubMed ID: 11113387 DOI: 10.1016/s8756-3282(00)00396-3

13683 Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity Blood 2000 96(5):1953-60. PubMed ID: 10961900

1898 Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines Biochem Biophys Res Commun 2000 275(3):768-75 PubMed ID: 10973797 DOI: 10.1006/bbrc.2000.3379

2998 Sakai H, Nakamura F, Kuno M Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts J Physiol 1999 515:157-168 PubMed ID: 9925886 DOI: 10.1111/j.1469-7793.1999.157ad.x

2545 Kitazawa R, Kitazawa S, Maeda S Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1999 1445:134-41 PubMed ID: 10209265 DOI: 10.1016/s0167-4781(99)00032-9

2370 Otsuka E, Yamaguchi A, Hirose S, Hagiwara H Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid Am J Physiol 1999 277(1 Pt 1):132-138 PubMed ID: 10409116 DOI: 10.1152/ajpcell.1999.277.1.C132

2420 Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol 1999 383:387-93 PubMed ID: 10594333 DOI: 10.1016/s0014-2999(99)00551-8

5398 Shalhoub V, Faust J, Boyle WJ, Dunstan CR, Kelley M, Kaufman S, Scully S, Van G, Lacey DL. Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. J Cell Biochem 1999 72(2):251-61 PubMed ID: 10022507

3960 Fujiwara M, Tagashira S, Harada H, Ogawa S, Katsumata T, Nakatsuka M, Komori T, Takada H. Isolation and characterization of the distal promoter region of mouse Cbfa1. Biochim Biophys Acta 1999 1446(3):265-72 PubMed ID: 10524201 DOI: 10.1016/s0167-4781(99)00113-x

3964 Nagai M, Sato N. Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochem Biophys Res Commun 1999 257(3):719-23 PubMed ID: 10208850 DOI: 10.1006/bbrc.1999.0524

3967 Tomohiro ShimizuJe-Tae WooKazuo Nagai Screening for Bioactive Compounds that Induce the Differentiation of Bone Marrow-Derived Preadipocytic Cell Line, ST2, into the Cells of Osteoblastic Phenotype Animal Cell Technology: Basic & Applied Aspects 1999 10:353–356 DOI: 10.1007/0-306-46865-4_61

3973 Goseki-Sone M, Yamada A, Asahi K, Hirota A, Ezawa I, Iimura T. Phosphate depletion enhances tissue-nonspecific alkaline phosphatase gene expression in a cultured mouse marrow stromal cell line ST2. Biochem Biophys Res Commun 1999 265(1):24-8 PubMed ID: 10548485 DOI: 10.1006/bbrc.1999.1624

3529 Quinn JM, Morfis M, Lam MH, Elliott J, Kartsogiannis V, Williams ED, Gillespie MT, Martin TJ, Sexton PM. Calcitonin receptor antibodies in the identification of osteoclasts. Bone 1999 25(1):1-8 PubMed ID: 10423015 DOI: 10.1016/s8756-3282(99)00094-0

6648 Isaacs SD, Fan X, Fan D, Gewant H, Murphy TC, Farmer P, Taylor WR, Nanes MS, Rubin J. Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells. J Cell Physiol 1999 179(2):193-200 PubMed ID: 10199558 DOI: 10.1002/(SICI)1097-4652(199905)179:2<193::AID-JCP9>3.0.CO;2-3

13802 Yano K, Tsuda E, Washida N, Kobayashi F, Goto M, Harada A, Ikeda K, Higashio K, Yamada Y. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis J Bone Miner Res 1999 14(4):518-27 PubMed ID: 10234572 DOI: 10.1359/jbmr.1999.14.4.518

1903 Nakagawa N, Yasuda H, Yano K, Mochizuki Si, Kobayashi N, Fujimoto H, Yamaguchi K, Shima N, Morinaga T, Higashio K. Basic fibroblast growth factor inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D(3) through suppressing the production of osteoclast differentiation factor Biochem Biophys Res Commun 1999 265(1):45-50 PubMed ID: 10548488 DOI: 10.1006/bbrc.1999.1621

2274 Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms. J Bone Miner Res 1998 13:986-95 PubMed ID: 9626630 DOI: 10.1359/jbmr.1998.13.6.986

3943 Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K, Akatsu T. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun. 1998 252(3):747-52 PubMed ID: 9837778 DOI: 10.1006/bbrc.1998.9723

3947 Takai H, Kanematsu M, Yano K, Tsuda E, Higashio K, Ikeda K, Watanabe K, Yamada Y. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem 1998 273(42):27091-6 PubMed ID: 9765225 DOI: 10.1074/jbc.273.42.27091

3949 Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M, Kanno T, Murakami A, Tsuda E, Morinaga T, Higashio K. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology. 1998 139(3):1329-37 PubMed ID: 9492069 DOI: 10.1210/endo.139.3.5837

3950 Yamaguchi T, Chattopadhyay N, Kifor O, Brown EM. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology 1998 139(8):3561-8 PubMed ID: 9681508 DOI: 10.1210/endo.139.8.6163

3951 Harada H, Kuboi Y, Miki R, Honda C, Masushige S, Nakatsuka M, Koga Y, Kato S. Cloning of rabbit TR4 and its bone cell-specific activity to suppress estrogen receptor-mediated transactivation. Endocrinology 1998 139(1):204-12 PubMed ID: 9421416 DOI: 10.1210/endo.139.1.5682

9167 K N Weilbaecher, C L Hershey, C M Takemoto, M A Horstmann, T J Hemesath, A H Tashjian, D E Fisher Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3 J Exp Med 1998 187 (5), 775-85 PubMed ID: 9480987 DOI: 10.1084/jem.187.5.775

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15428 Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 1998 93(2):165-76 PubMed ID: 9568710 DOI: 10.1016/s0092-8674(00)81569-x

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1089 Takase M, Imamura T, Sampath TK, Takeda K, Ichijo H, Miyazono K, Kawabata M. Induction of Smad6 mRNA by bone morphogenetic proteins Biochem Biophys Res Commun 1998 244(1):26-9 PubMed ID: 9514869 DOI: 10.1006/bbrc.1998.8200

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1210 Breuil V, Cosman F, Stein L, Horbert W, Nieves J, Shen V, Lindsay R, Dempster DW. Human osteoclast formation and activity in vitro: effects of alendronate J Bone Miner Res 1998 13(11):1721-9. PubMed ID: 9797481 DOI: 10.1359/jbmr.1998.13.11.1721

1292 Muguruma Y, Lee MY. Isolation and characterization of murine clonogenic osteoclast progenitors by cell surface phenotype analysis Blood 1998 91(4):1272-9 PubMed ID: 9454757

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18049 Wakikawa T, Shioi A, Hino M, Inaba M, Nishizawa Y, Tatsumi N, Morii H, Otani S. Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells Endocrinology 1997 138(10):4160-6 PubMed ID: 9322925 DOI: 10.1210/endo.138.10.5438

18082 Kania JR, Kehat-Stadler T, Kupfer SR. CD44 antibodies inhibit osteoclast formation J Bone Miner Res 1997 12(8):1155-64 PubMed ID: 9258745 DOI: 10.1359/jbmr.1997.12.8.1155

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17997 Clohisy DR, Ogilvie CM, Carpenter RJ, Ramnaraine ML. Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts J Orthop Res 1996 14(1):2-6 PubMed ID: 8618161 DOI: 10.1002/jor.1100140103

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1327 Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989 125:1805-13 PubMed ID: 2676473 DOI: 10.1210/endo-125-4-1805