CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0224 : ST2]

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12040 Tabuchi Y, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Takeuchi SI, Shiiba M, Mochizuki T. Low-intensity pulsed ultrasound promotes the expression of immediate-early genes in mouse ST2 bone marrow stromal cells. J Med Ultrason (2001) 2020 PubMed ID: 32026128 DOI: 10.1007/s10396-020-01007-9

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13151 Cornelis R, Hahne S, Taddeo A, Petkau G, Malko D, Durek P, Thiem M, Heiberger L, Peter L, Mohr E, Klaeden C, Tokoyoda K, Siracusa F, Hoyer BF, Hiepe F, Mashreghi MF, Melchers F, Chang HD, Radbruch A. Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells. Cell Rep 2020 PubMed ID: 32755576 DOI: 10.1016/j.celrep.2020.107982

13197 Yahiro Y, Maeda S, Morikawa M, Koinuma D, Jokoji G, Ijuin T, Komiya S, Kageyama R, Miyazono K, Taniguchi N. BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts. Bone Res 2020 PubMed ID: 32923015 DOI: 10.1038/s41413-020-00106-0

13352 Ma O, Le T, Talbott G, HoangThao Nguyen T, Ha D, Ho L. Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity. Pharmacol Res Perspect 2020 PubMed ID: 33191653 DOI: 10.1002/prp2.670

14181 Tsubaki M, Seki S, Takeda T, Chihara A, Arai Y, Morii Y, Imano M, Satou T, Shimomura K, Nishida S. The HGF/Met/NF-κB Pathway Regulates RANKL Expression in Osteoblasts and Bone Marrow Stromal Cells Int J Mol Sci 2020 21(21):7905 PubMed ID: 33114380 DOI: 10.3390/ijms21217905

14295 Takeda T, Tsubak M, Genno S, Matsuda T, Yamamoto Y, Ueda E, Imano M, Satou T, Nishida S. CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma J Physiol Pharmacol 2020 71(4) PubMed ID: 33214335 DOI: 10.26402/jpp.2020.4.02

14500 Asparuhova MB, Chappuis V, Stähli A, Buser D, Sculean A. Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts Clin Oral Investig 2020 24(11):3923-3937 PubMed ID: 32236725 DOI: 10.1007/s00784-020-03259-8

11318 Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation. Cytotechnology 2019 PubMed ID: 30474804 DOI: 10.1007/s10616-018-0236-2

11323 Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30502084 DOI: 10.1016/j.bbrc.2018.11.154

11366 Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B. Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling. J. Cell. Mol. Med. 2019 PubMed ID: 30614617 DOI: 10.1111/jcmm.14126

11439 Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM. Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. Cell Metab. 2019 PubMed ID: 30773468 DOI: 10.1016/j.cmet.2019.01.016

11460 Strauss FJ, Di Summa F, Stähli A, Matos L, Vaca F, Schuldt G, Gruber R. TGF-β activity in acid bone lysate adsorbs to titanium surface. Clin Implant Dent Relat Res 2019 PubMed ID: 30817088 DOI: 10.1111/cid.12734

11607 Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. Cell. Signal. 2019 PubMed ID: 31228531 DOI: 10.1016/j.cellsig.2019.109345

11659 Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice JBMR Plus 2019 PubMed ID: 31667457 DOI: 10.1002/jbm4.10201

11813 Böhm AM, Dirckx N, Tower RJ, Peredo N, Vanuytven S, Theunis K, Nefyodova E, Cardoen R, Lindner V, Voet T, Van Hul M, Maes C. Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling. Dev. Cell 2019 PubMed ID: 31543445 DOI: 10.1016/j.devcel.2019.08.013

11856 Hamaya E, Fujisawa T, Tamura M. Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells. Int. J. Mol. Med. 2019 PubMed ID: 31638177 DOI: 10.3892/ijmm.2019.4376

11883 Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis. FASEB J. 2019 PubMed ID: 31675485 DOI: 10.1096/fj.201802729RRR

6927 Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH.Front Immunol. 2019 May 28;10:1164. doi: 10.3389/fimmu.2019.01164. eCollection 2019. Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. Front Immunol 2019 2019 May 28;10:1164 PubMed ID: 31191537 DOI: 10.3389/fimmu.2019.01164

6935 SOO LENG LEE*, ZAINAL ARIFF ABDUL RAHMAN, HIDETSUGU TSUJIGIWA, MEI HAMADA, KIYOFUMI TAKABATAKE, KEISUKE NAKANO, HITOSHI NAGATSUKA & CHONG HUAT SIAR An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling Sains Malaysiana 2019 48(8):1697–1706 DOI: 10.17576/jsm-2019-4808-15

9727 Jinlu Dai, June Escara-Wilke, Jill M Keller, Younghun Jung, Russell S Taichman, Kenneth J Pienta, Evan T Keller Primary Prostate Cancer Educates Bone Stroma Through Exosomal Pyruvate Kinase M2 to Promote Bone Metastasis J Exp Med 2019 216(12):2883-2899 PubMed ID: 31548301 DOI: 10.1084/jem.20190158

10553 Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto and Keiichi Sasaki Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant Appl Sci 2019 9(1):172 DOI: 10.3390/app9010172

12590 Mashimo K, Tsubaki M, Takeda T, Asano R, Jinushi M, Imano M, Satou T, Sakaguchi K, Nishida S. RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells Clin Exp Med 2019 19(1):133-141 PubMed ID: 30291461 DOI: 10.1007/s10238-018-0531-4

12591 Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation Biochem Biophys Res Commun 2019 509(2):435-440 PubMed ID: 30594398 DOI: 10.1016/j.bbrc.2018.12.093

12592 Takeno A, Kanazawa I, Tanaka KI, Notsu M, Sugimoto T. Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway Int J Mol Sci 2019 20(10):2481 PubMed ID: 31137461 DOI: 10.3390/ijms20102481

10459 Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. J. Cell. Physiol. 2018 233:2549-2559 PubMed ID: 28786489 DOI: 10.1002/jcp.26130

10666 Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T. Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts via Smad-independent mechanisms. Endocr. J. 2018 65:291-298 PubMed ID: 29249772 DOI: 10.1507/endocrj.EJ17-0229

10731 Kumeta M, Takahashi D, Takeyasu K, Yoshimura SH. Cell type-specific suppression of mechanosensitive genes by audible sound stimulation. PLoS ONE 2018 13:e0188764 PubMed ID: 29385174 DOI: 10.1371/journal.pone.0188764

10764 Takeda T, Tsubaki M, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S. Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Biomed. Pharmacother. 2018 100:486-494 PubMed ID: 29477912 DOI: 10.1016/j.biopha.2018.02.019

10844 Takenaka Y, Mikami K, Seno S, Matsuda H. Automated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells. BMC Bioinformatics 2018 19:89 PubMed ID: 29745848 DOI: 10.1186/s12859-018-2072-y

11198 Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H. Coupling of bone resorption and formation by RANKL reverse signalling. Nature 2018 561(7722):195-200 PubMed ID: 30185903 DOI: 10.1038/s41586-018-0482-7

11099 Asparuhova MB, Caballe-Serrano J, Buser D, Chappuis V. Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity. Int J Oral Sci 2018 10(2):20 PubMed ID: 29895828 DOI: 10.1038/s41368-018-0021-2

11124 Kida J, Hata K, Nakamura E, Yagi H, Takahata Y, Murakami T, Maeda Y, Nishimura R. Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a. Sci Rep 2018 8(1):10375 PubMed ID: 29991769 DOI: 10.1038/s41598-018-28711-4

11153 Kuroda M, Ueda K, Kioka N. Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells. Sci Rep 2018 8(1):11581 PubMed ID: 30068914 DOI: 10.1038/s41598-018-29700-3

11193 Eppell SJ, Tong W, McMasters J, Soenjaya Y, Barbu AM, Ko A, Baskin JZ. Minor Review: An Overview of a Synthetic Nanophase Bone Substitute. Materials (Basel) 2018 11(9) PubMed ID: 30158464 DOI: 10.3390/ma11091556

4348 Kokubun K, Matsumura S, Yudasaka M, Iijima S, Shiba K. Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide. Int J Nanomedicine 2018 PubMed ID: 29588591 DOI: 10.2147/IJN.S155913

4349 Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T. Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells. Int J Mol Sci 2018 PubMed ID: 29904032 DOI: 10.3390/ijms19061772

4350 Aoto K, Ito K, Aoki S. Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts. Oncotarget 2018 PubMed ID: 30344924 DOI: 10.18632/oncotarget.26124

4351 Dubon MJ, Yu J, Choi S, Park KS. Transforming growth factor β induces bone marrow mesenchymal stem cell migration via noncanonical signals and N-cadherin. J. Cell. Physiol. 2018 PubMed ID: 28213973 DOI: 10.1002/jcp.25863

4502 Choi SM, Park JW. Multifunctional effects of a modification of SLA titanium implant surface with strontium-containing nanostructures on immunoinflammatory and osteogenic cell function. J Biomed Mater Res A 2018 106(12):3009-3020 PubMed ID: 30192064 DOI: 10.1002/jbm.a.36490

14552 Kota SK, Roening C, Patel N, Kota SB, Baron R. PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression Bone 2018 117:37-46 PubMed ID: 30189247 DOI: 10.1016/j.bone.2018.08.025

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9589 Miron RJ, Fujioka-Kobayashi M, Zhang Y, Caballé-Serrano J, Shirakata Y, Bosshardt DD, Buser D, Sculean A. Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine-derived natural bone mineral. Clin Oral Implants Res 2017 28:327-333 PubMed ID: 26919609 DOI: 10.1111/clr.12802

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9874 Fujioka-Kobayashi M, Mottini M, Kobayashi E, Zhang Y, Schaller B, Miron RJ. An in vitro study of fibrin sealant as a carrier system for recombinant human bone morphogenetic protein (rhBMP)-9 for bone tissue engineering. J Craniomaxillofac Surg 2017 45:27-32 PubMed ID: 27840120 DOI: 10.1016/j.jcms.2016.10.008

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10125 Fujioka-Kobayashi M, Schaller B, Saulacic N, Pippenger BE, Zhang Y, Miron RJ. Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2. Clin Exp Dent Res 2017 3:32-40 PubMed ID: 29744176 DOI: 10.1002/cre2.55

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10395 Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A. Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. Int. J. Oncol. 2017 51:625-632 PubMed ID: 28656278 DOI: 10.3892/ijo.2017.4050

10401 Ouji Y, Sakagami M, Omori H, Higashiyama S, Kawai N, Kitahara T, Wanaka A, Yoshikawa M. Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells. Stem Cell Res 2017 23:50-56 PubMed ID: 28689068 DOI: 10.1016/j.scr.2017.06.013

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14442 Fujioka-Kobayashi M, Schaler B, Shirakata Y, Nakamura T, Noguchi K, Zhang Y, Miron RJ. Comparison of Two Porcine Collagen Membranes Combined with rhBMP-2 and rhBMP-9 on Osteoblast Behavior In Vitro Int J Oral Maxillofac Implants 2017 32(4):e221-e230 PubMed ID: 28708926 DOI: 10.11607/jomi.5652

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6610 Nishikawa R, Anada T, Ishiko-Uzuka R, Suzuki O. Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway. Dent Mater J 2014 33(2):242-51 PubMed ID: 24598239 DOI: 10.4012/dmj.2013-226

9332 Joji Kusuyama, Kenjiro Bandow, Mitsuo Shamoto, Kyoko Kakimoto, Tomokazu Ohnishi, Tetsuya Matsuguchi Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines Through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway J Biol Chem 2014 289(15):10330-44 PubMed ID: 24550383 DOI: 10.1074/jbc.M113.546382

9336 Ken-ichiro Tanaka, Hiroshi Kaji, Toru Yamaguchi, Ippei Kanazawa, Lucie Canaff, Geoffrey N Hendy, Toshitsugu Sugimoto Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK-eIF2α-ATF4 Pathway in the Commitment of Myoblastic Into Osteoblastic Cells Calcif Tissue Int 2014 94(4):454-64 PubMed ID: 24362451 DOI: 10.1007/s00223-013-9828-1

9345 Sunao Takeshita, Toshio Fumoto, Yoshinori Naoe, Kyoji Ikeda Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL J Biol Chem 2014 289(24):16699-710 PubMed ID: 24753250 DOI: 10.1074/jbc.M114.547919

9347 Jinlu Dai, Honglai Zhang, Andreas Karatsinides, Jill M Keller, Kenneth M Kozloff, Dana T Aftab, Frauke Schimmoller, Evan T Keller Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions Clin Cancer Res 2014 20(3):617-30 PubMed ID: 24097861 DOI: 10.1158/1078-0432.CCR-13-0839

9348 W Ariyoshi, T Okinaga, C B Knudson, W Knudson, T Nishihara High Molecular Weight Hyaluronic Acid Regulates Osteoclast Formation by Inhibiting Receptor Activator of NF-κB Ligand Through Rho Kinase Osteoarthritis Cartilage 2014 22(1):111-20 PubMed ID: 24185105 DOI: 10.1016/j.joca.2013.10.013

9350 Masakazu Notsu, Toru Yamaguchi, Kyoko Okazaki, Ken-ichiro Tanaka, Noriko Ogawa, Ippei Kanazawa, Toshitsugu Sugimoto Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion Endocrinology 2014 155(7):2402-10 PubMed ID: 24758301 DOI: 10.1210/en.2013-1818

9352 Kiyoshi Mori, Riko Kitazawa, Takeshi Kondo, Michiko Mori, Yasuhiro Hamada, Michiru Nishida, Yasuhiro Minami, Ryuma Haraguchi, Yutaka Takahashi, Sohei Kitazawa Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene PLoS One 2014 9(7):e102797 PubMed ID: 25036934 DOI: 10.1371/journal.pone.0102797

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9278 Shingen Nakamura, Hirokazu Miki, Shinsuke Kido, Ayako Nakano, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Keiichiro Watanabe, Takeshi Harada, Shiro Fujii, Kyoko Takeuchi, Kumiko Kagawa, Shuji Ozaki, Toshio Matsumoto, Masahiro Abe Activating Transcription Factor 4, an ER Stress Mediator, Is Required For, but Excessive ER Stress Suppresses Osteoblastogenesis by Bortezomib Int J Hematol 2013 98(1):66-73 PubMed ID: 23708974 DOI: 10.1007/s12185-013-1367-z

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8113 Okui T, Shimo T, Fukazawa T, Kurio N, Hassan NM, Honami T, Takaoka M, Naomoto Y, Sasaki A. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol. Cancer Ther. 2010 9:2960-9 PubMed ID: 20858724 DOI: 10.1158/1535-7163.MCT-10-0489

8139 Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT. Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer. Cancer Gene Ther. 2010 17:893-905 PubMed ID: 20798695 DOI: 10.1038/cgt.2010.47

8182 Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K. Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway. Bone 2010 47:756-65 PubMed ID: 20637325 DOI: 10.1016/j.bone.2010.07.008

8220 Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M. Cytodifferentiation activity of synthetic human enamel sheath protein peptides. J. Periodont. Res. 2010 45:643-9 PubMed ID: 20572923 DOI: 10.1111/j.1600-0765.2010.01279.x

8295 Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schönbach C, Suda T, Mizuno Y, Okazaki Y. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet 2010 6(7):e1001019 PubMed ID: 20628571 DOI: 10.1371/journal.pgen.1001019

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8359 Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology 2009 61:125-34 PubMed ID: 20162352 DOI: 10.1007/s10616-010-9253-5

8493 Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 2009 114:4441-50 PubMed ID: 19762485 DOI: 10.1182/blood-2009-07-233718

8530 Yoshikawa H, Yoshioka K, Nakase T, Itoh K. Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot study. Clin. Orthop. Relat. Res. 2009 467:3087-95 PubMed ID: 19609629 DOI: 10.1007/s11999-009-0976-6

8570 Fuji T, Anada T, Honda Y, Shiwaku Y, Koike H, Kamakura S, Sasaki K, Suzuki O. Octacalcium phosphate-precipitated alginate scaffold for bone regeneration. Tissue Eng Part A 2009 15:3525-35 PubMed ID: 19456237 DOI: 10.1089/ten.TEA.2009.0048

8584 Tanaka T, Kawashima H, Ohnishi K, Matsumura K, Yoshimura R, Matsuyama M, Kuratsukuri K, Nakatani T. Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. Anticancer Res. 2009 29:1089-94 PubMed ID: 19414350

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8766 Yamachika E, Tsujigiwa H, Shirasu N, Ueno T, Sakata Y, Fukunaga J, Mizukawa N, Yamada M, Sugahara T. Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads. J Biomed Mater Res A 2009 88:599-607 PubMed ID: 18314893 DOI: 10.1002/jbm.a.31833

6536 Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol 2009 9:70 PubMed ID: 20025746 DOI: 10.1186/1471-213X-9-70

8180 Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells. BMC Musculoskelet Disord 2009 10:109 PubMed ID: 19728893 DOI: 10.1186/1471-2474-10-109

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6530 Anada T, Kumagai T, Honda Y, Masuda T, Kamijo R, Kamakura S, Yoshihara N, Kuriyagawa T, Shimauchi H, Suzuki O. Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells. Tissue Eng Part A 2008 14(6):965-78 PubMed ID: 19230123 DOI: 10.1089/ten.tea.2007.0339

7863 Maehira F1, Iinuma Y, Eguchi Y, Miyagi I, Teruya S. Effects of soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice. J Bone Miner Metab 2008 26(5):446-55 PubMed ID: 18758902 DOI: 10.1007/s00774-007-0845-x

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7920 Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y. Effects of alkylphenols on bone metabolism in vivo and in vitro. Toxicol Lett 2008 181(1):13-8 PubMed ID: 18621119 DOI: 10.1016/j.toxlet.2008.06.863

7930 You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 2008 42(1):172-9 PubMed ID: 17997378 DOI: 10.1016/j.bone.2007.09.047

7073 Tsubaki M, Kato C, Manno M, Ogaki M, Satou T, Itoh T, Kusunoki T, Tanimori Y, Fujiwara K, Matsuoka H, Nishida S. Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways. Mol Cell Biochem 2007 304(1-2):53-60 PubMed ID: 17549607 DOI: 10.1007/s11010-007-9485-7

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7383 Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B. Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem 2007 102(6):1458-71 PubMed ID: 17486635 DOI: 10.1002/jcb.21366

7386 Amano S, Arai M, Goto S, Togari A. Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells. Biochim Biophys Acta 2007 1770(6):966-73 PubMed ID: 17383824 DOI: 10.1016/j.bbagen.2007.02.009

7391 Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y. Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner. J Immunol 2007 179(10):6715-24 PubMed ID: 17982061 DOI: 10.4049/jimmunol.179.10.6715

7392 Niikura K, Nakajima S, Takano M, Yamazaki H. FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats. Bone 2007 40(4):888-94 PubMed ID: 17157574 DOI: 10.1016/j.bone.2006.10.015

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6151 Nagayoshi K, Ohkawa H, Yorozu K, Higuchi M, Higashi S, Kubota N, Fukui H, Imai N, Gojo S, Hata J, Kobayashi Y, Umezawa A. Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo formation of a stem cell niche depends on dynamic, but not stable, membranous ossification. J Cell Physiol 2006 208(1):188-94 PubMed ID: 16575918 DOI: 10.1002/jcp.20652

6493 Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 2006 99(1):196-208 PubMed ID: 16598753 DOI: 10.1002/jcb.20890

6997 Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K. Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells. Bone 2006 38(2):206-14 PubMed ID: 16203197 DOI: 10.1016/j.bone.2005.08.006

7012 Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T. CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol 2006 26(16):6105-16 PubMed ID: 16880521 DOI: 10.1128/MCB.02429-05

7024 Shin HH, Kim SJ, Kang SY, Lee DS, Choi HS. Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprotegerin in bone marrow stromal cells. Bone 2006 39(4):716-23 PubMed ID: 16750437 DOI: 10.1016/j.bone.2006.03.015

12830 Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano A. Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis Microbes Infect 2006 8(4):1025-34 PubMed ID: 16476562 DOI: 10.1016/j.micinf.2005.10.021

13953 Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M. Porcine enamel protein fractions contain transforming growth factor-beta1 J Periodontol 2006 77(10):1688-94 PubMed ID: 17032111 DOI: 10.1902/jop.2006.050352

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3294 Deshimaru, Ryota, Ishitani, Ken, Makita, Kazuya, Horiguchi, Fumi, Nozawa, Shiro Analysis of fatty acid composition in human bone marrow aspirates. Keio J Med 2005 54:150-5 PubMed ID: 16237277 DOI: 10.2302/kjm.54.150

2879 Nishida S, Tsubaki M, Hoshino M, Namimatsu A, Uji H, Yoshioka S, Tanimori Y, Yanae M, Iwaki M, Irimajiri K Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. Biochem Biophys Res Commun 2005 328:91-7 PubMed ID: 15670755 DOI: 10.1016/j.bbrc.2004.12.145

3366 Oursler, Merry Jo, Bradley, Elizabeth W, Elfering, Sarah L, Giulivi, Cecilia Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis. Am J Physiol Cell Physiol 2005 288:C156-68 PubMed ID: 15342339 DOI: 10.1152/ajpcell.00092.2004

3183 Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol 2005 25:1971-9 PubMed ID: 15713650 DOI: 10.1128/MCB.25.5.1971-1979.2005

2843 Takeuchi, Tamotsu, Adachi, Yoshihiro, Ohtsuki, Yuji Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Am J Pathol 2005 166:1817-26 PubMed ID: 15920166 DOI: 10.1016/S0002-9440(10)62491-1

3377 Hall, Christopher L, Bafico, Anna, Dai, Jinlu, Aaronson, Stuart A, Keller, Evan T Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res 2005 65:7554-60 PubMed ID: 16140917 DOI: 10.1158/0008-5472.CAN-05-1317

8993 Tsujigiwa H, Nagatsuka H, Gunduz M, Rodriguez A, Rivera RS, Legeros RZ, Inoue M, Nagai N. Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells. J Biomed Mater Res A 2005 75:210-5 PubMed ID: 16059889 DOI: 10.1002/jbm.a.30416

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6877 Liu J, Yang H, Liu W, Cao X, Feng X. Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. J Cell Biochem 2005 96(4):716-27 PubMed ID: 16052479 DOI: 10.1002/jcb.20569

2871 Notoya M, Otsuka E, Yamaguchi A, Hagiwara H Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochem Biophys Res Commun 2004 324:655-60 PubMed ID: 15474477 DOI: 10.1016/j.bbrc.2004.09.101

2910 Fan, Xian, Roy, Eileen, Zhu, Liping, Murphy, Tamara C, Ackert-Bicknell, Cheryl, Hart, C Michael, Rosen, Clifford, Nanes, Mark S, Rubin, Janet Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology 2004 145:751-9 PubMed ID: 14563699 DOI: 10.1210/en.2003-0726

2926 French, Dorothy M, Kaul, Raji J, D'Souza, Aloma L, Crowley, Craig W, Bao, Min, Frantz, Gretchen D, Filvaroff, Ellen H, Desnoyers, Luc WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004 165:855-67 PubMed ID: 15331410 DOI: 10.1016/S0002-9440(10)63348-2

6737 Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H. Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells. Biochem Pharmacol 2004 67(1):119-27 PubMed ID: 14667934 DOI: 10.1016/j.bcp.2003.08.038

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6662 Fratzl-Zelman N, Glantschnig H, Rumpler M, Nader A, Ellinger A, Varga F. The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones. Cell Biol Int 2003 27(6):459-68 PubMed ID: 12798773 DOI: 10.1016/s1065-6995(03)00037-4

6696 Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003 144(2):681-92 PubMed ID: 12538631 DOI: 10.1210/en.2002-220682

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2518 Yoneda S, Itoh D, Kuroda S, Kondo H, Umezawa A, Ohya K, Ohyama T, Kasugai S. The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect J Periodontal Res 2003 38(3):333-42 PubMed ID: 12753373 DOI: 10.1034/j.1600-0765.2003.00667.x

2773 Sakiyama H, Nonaka T, Masuda R, Inoue N, Kuboki Y, Iijima M, Hirabayasi Y, Takahagi M, Yoshida K, Kuriiwa K, Yoshida M, Imajoh-Ohmi S Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP). Cell Tissue Res 2002 309:269-79 PubMed ID: 12172786 DOI: 10.1007/s00441-002-0587-y

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6673 Kuriyama K, Higuchi C, Tanaka K, Yoshikawa H, Itoh K. A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein-2-induced bone formation in vivo. Biochem Biophys Res Commun 2002 299(5):903-9 PubMed ID: 12470665 DOI: 10.1016/s0006-291x(02)02754-7

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6702 Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology 2002 143(6):2349-56 PubMed ID: 12021200 DOI: 10.1210/endo.143.6.8854

17294 Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway J Biol Chem 2002 277(16):14221-6 PubMed ID: 11827970 DOI: 10.1074/jbc.M111551200

17296 Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo J Clin Endocrinol Metab 2002 87(9):4273-9 PubMed ID: 12213884 DOI: 10.1210/jc.2002-020656

17299 Ishida A, Fujita N, Kitazawa R, Tsuruo T. Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone J Biol Chem 2002 277(29):26217-24 PubMed ID: 12011070 DOI: 10.1074/jbc.M111093200

2771 Sakiyama H, Masuda R, Inoue N, Yamamoto K, Kuriiwa K, Nakagawa K, Yoshida K Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers. J Bone Miner Metab 2001 19:220-7 PubMed ID: 11448014 DOI: 10.1007/s007740170024

2772 Masuda R, Sakiyama H, Nonaka T, Kwan A, Nakagawa K, Moriya H, Imajoh-Ohmi S, Honjo M, Yoshida K Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines. Cell Tissue Res 2001 304:351-9 PubMed ID: 11456411 DOI: 10.1007/s004410100347

6657 Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 2001 166(5):3574-9 PubMed ID: 11207318 DOI: 10.4049/jimmunol.166.5.3574

6663 Yamagishi T, Otsuka E, Hagiwara H. Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis. Endocrinology 2001 142(8):3632-7 PubMed ID: 11459812 DOI: 10.1210/endo.142.8.8310

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16947 Fan X, Fan D, Gewant H, Royce CL, Nanes MS, Rubin J. Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells Am J Physiol Endocrinol Metab 2001 280(1):E103-11. PubMed ID: 11120664 DOI: 10.1152/ajpendo.2001.280.1.E103

16962 Yano K, Shibata O, Mizuno A, Kobayashi F, Higashio K, Morinaga T, Tsuda E. Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy Biochem Biophys Res Commun 2001 288(1):217-24 PubMed ID: 11594776 DOI: 10.1006/bbrc.2001.5745

17283 Yamanaka R, Zullo SA, Tanaka R, Blaese M, Xanthopoulos KG. Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki forest virus-mediated complementary DNA J Neurosurg 2001 94(3):474-81 PubMed ID: 11235953 DOI: 10.3171/jns.2001.94.3.0474

2430 Otsuka E, Kato Y, Hirose S, Hagiwara H Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 2000 141:3006-11 PubMed ID: 10919289 DOI: 10.1210/endo.141.8.7597

5400 Kawaguchi N, Noda M. Mitf is expressed in osteoclast progenitors in vitro. Exp Cell Res 2000 260(2):284-91 PubMed ID: 11035923 DOI: 10.1006/excr.2000.5020

3984 Naruse K, Mikuni-Takagaki Y, Azuma Y, Ito M, Oota T, Kameyama K, Itoman M. Anabolic response of mouse bone-marrow-derived stromal cell clone ST2 cells to low-intensity pulsed ultrasound. Biochem Biophys Res Commun 2000 268(1):216-20 PubMed ID: 10652238 DOI: 10.1006/bbrc.2000.2094

3987 Gruber R, Nothegger G, Ho GM, Willheim M, Peterlik M. Differential stimulation by PGE(2) and calcemic hormones of IL-6 in stromal/osteoblastic cells. Biochem Biophys Res Commun 2000 270(3):1080-5 PubMed ID: 10772953 DOI: 10.1006/bbrc.2000.2573

3988 Koyama A, Otsuka E, Inoue A, Hirose S, Hagiwara H. Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E(2). Eur J Pharmacol 2000 391(3):225-31 PubMed ID: 10729362 DOI: 10.1016/s0014-2999(00)00100-x

3990 Takami M, Takahashi N, Udagawa N, Miyaura C, Suda K, Woo JT, Martin TJ, Nagai K, Suda T. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 2000 141(12):4711-9 PubMed ID: 11108286 DOI: 10.1210/endo.141.12.7852

3996 Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone 2000 27(6):769-76 PubMed ID: 11113387 DOI: 10.1016/s8756-3282(00)00396-3

13683 Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity Blood 2000 96(5):1953-60. PubMed ID: 10961900

1898 Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines Biochem Biophys Res Commun 2000 275(3):768-75 PubMed ID: 10973797 DOI: 10.1006/bbrc.2000.3379

2998 Sakai H, Nakamura F, Kuno M Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts J Physiol 1999 515:157-168 PubMed ID: 9925886 DOI: 10.1111/j.1469-7793.1999.157ad.x

2545 Kitazawa R, Kitazawa S, Maeda S Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1999 1445:134-41 PubMed ID: 10209265 DOI: 10.1016/s0167-4781(99)00032-9

2370 Otsuka E, Yamaguchi A, Hirose S, Hagiwara H Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid Am J Physiol 1999 277(1 Pt 1):132-138 PubMed ID: 10409116 DOI: 10.1152/ajpcell.1999.277.1.C132

2420 Yuhara S, Kasagi S, Inoue A, Otsuka E, Hirose S, Hagiwara H Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol 1999 383:387-93 PubMed ID: 10594333 DOI: 10.1016/s0014-2999(99)00551-8

5398 Shalhoub V, Faust J, Boyle WJ, Dunstan CR, Kelley M, Kaufman S, Scully S, Van G, Lacey DL. Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. J Cell Biochem 1999 72(2):251-61 PubMed ID: 10022507

3960 Fujiwara M, Tagashira S, Harada H, Ogawa S, Katsumata T, Nakatsuka M, Komori T, Takada H. Isolation and characterization of the distal promoter region of mouse Cbfa1. Biochim Biophys Acta 1999 1446(3):265-72 PubMed ID: 10524201 DOI: 10.1016/s0167-4781(99)00113-x

3964 Nagai M, Sato N. Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochem Biophys Res Commun 1999 257(3):719-23 PubMed ID: 10208850 DOI: 10.1006/bbrc.1999.0524

3967 Tomohiro ShimizuJe-Tae WooKazuo Nagai Screening for Bioactive Compounds that Induce the Differentiation of Bone Marrow-Derived Preadipocytic Cell Line, ST2, into the Cells of Osteoblastic Phenotype Animal Cell Technology: Basic & Applied Aspects 1999 10:353–356 DOI: 10.1007/0-306-46865-4_61

3973 Goseki-Sone M, Yamada A, Asahi K, Hirota A, Ezawa I, Iimura T. Phosphate depletion enhances tissue-nonspecific alkaline phosphatase gene expression in a cultured mouse marrow stromal cell line ST2. Biochem Biophys Res Commun 1999 265(1):24-8 PubMed ID: 10548485 DOI: 10.1006/bbrc.1999.1624

3529 Quinn JM, Morfis M, Lam MH, Elliott J, Kartsogiannis V, Williams ED, Gillespie MT, Martin TJ, Sexton PM. Calcitonin receptor antibodies in the identification of osteoclasts. Bone 1999 25(1):1-8 PubMed ID: 10423015 DOI: 10.1016/s8756-3282(99)00094-0

6648 Isaacs SD, Fan X, Fan D, Gewant H, Murphy TC, Farmer P, Taylor WR, Nanes MS, Rubin J. Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells. J Cell Physiol 1999 179(2):193-200 PubMed ID: 10199558 DOI: 10.1002/(SICI)1097-4652(199905)179:2<193::AID-JCP9>3.0.CO;2-3

13802 Yano K, Tsuda E, Washida N, Kobayashi F, Goto M, Harada A, Ikeda K, Higashio K, Yamada Y. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis J Bone Miner Res 1999 14(4):518-27 PubMed ID: 10234572 DOI: 10.1359/jbmr.1999.14.4.518

2274 Nishikawa M, Yamamoto M, Murakami T, Akatsu T, Kugai N, Nagata N A third-generation bisphosphonate, YM175, inhibits osteoclast formation in murine cocultures by inhibiting proliferation of precursor cells via supporting cell-dependent mechanisms. J Bone Miner Res 1998 13:986-95 PubMed ID: 9626630 DOI: 10.1359/jbmr.1998.13.6.986

3943 Murakami T, Yamamoto M, Ono K, Nishikawa M, Nagata N, Motoyoshi K, Akatsu T. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem Biophys Res Commun. 1998 252(3):747-52 PubMed ID: 9837778 DOI: 10.1006/bbrc.1998.9723

3947 Takai H, Kanematsu M, Yano K, Tsuda E, Higashio K, Ikeda K, Watanabe K, Yamada Y. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J Biol Chem 1998 273(42):27091-6 PubMed ID: 9765225 DOI: 10.1074/jbc.273.42.27091

3949 Yasuda H, Shima N, Nakagawa N, Mochizuki SI, Yano K, Fujise N, Sato Y, Goto M, Yamaguchi K, Kuriyama M, Kanno T, Murakami A, Tsuda E, Morinaga T, Higashio K. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology. 1998 139(3):1329-37 PubMed ID: 9492069 DOI: 10.1210/endo.139.3.5837

3950 Yamaguchi T, Chattopadhyay N, Kifor O, Brown EM. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology 1998 139(8):3561-8 PubMed ID: 9681508 DOI: 10.1210/endo.139.8.6163

3951 Harada H, Kuboi Y, Miki R, Honda C, Masushige S, Nakatsuka M, Koga Y, Kato S. Cloning of rabbit TR4 and its bone cell-specific activity to suppress estrogen receptor-mediated transactivation. Endocrinology 1998 139(1):204-12 PubMed ID: 9421416 DOI: 10.1210/endo.139.1.5682

9167 K N Weilbaecher, C L Hershey, C M Takemoto, M A Horstmann, T J Hemesath, A H Tashjian, D E Fisher Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3 J Exp Med 1998 187 (5), 775-85 PubMed ID: 9480987 DOI: 10.1084/jem.187.5.775

13808 Ragab AA, Lavish SA, Banks MA, Goldberg VM, Greenfield EM. Osteoclast differentiation requires ascorbic acid J Bone Miner Res 1998 13(6):970-7 PubMed ID: 9626628 DOI: 10.1359/jbmr.1998.13.6.970

15428 Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 1998 93(2):165-76 PubMed ID: 9568710 DOI: 10.1016/s0092-8674(00)81569-x

16637 Yamaguchi K, Kinosaki M, Goto M, Kobayashi F, Tsuda E, Morinaga T, Higashio K. Characterization of structural domains of human osteoclastogenesis inhibitory factor. J Biol Chem 1998 273:5117-23 PubMed ID: 9478964 DOI: 10.1074/jbc.273.9.5117

2997 Shibata T, Sakai H, Nakamura F, Shioi A, Kuno M Differential effect of high extracellular Ca2+ on K+ and Cl- conductances in murine osteoclasts. J Membr Biol 1997 158:59-67 PubMed ID: 9211721 DOI: 10.1007/s002329900243

18049 Wakikawa T, Shioi A, Hino M, Inaba M, Nishizawa Y, Tatsumi N, Morii H, Otani S. Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells Endocrinology 1997 138(10):4160-6 PubMed ID: 9322925 DOI: 10.1210/endo.138.10.5438

18082 Kania JR, Kehat-Stadler T, Kupfer SR. CD44 antibodies inhibit osteoclast formation J Bone Miner Res 1997 12(8):1155-64 PubMed ID: 9258745 DOI: 10.1359/jbmr.1997.12.8.1155

3938 Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997 234(1):137-42 PubMed ID: 9168977 DOI: 10.1006/bbrc.1997.6603

3939 Natsume T, Tomita S, Iemura S, Kinto N, Yamaguchi A, Ueno N. Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4. J Biol Chem 1997 272(17):11535-40 PubMed ID: 9111068 DOI: 10.1074/jbc.272.17.11535

1600 Quinn JM, Sabokbar A, Denne M, de Vernejoul MC, McGee JO, Athanasou NA. Inhibitory and stimulatory effects of prostaglandins on osteoclast differentiation Calcif Tissue Int 1997 60(1):63-70 PubMed ID: 9030482 DOI: 10.1007/s002239900187

2065 Jimi E, Shuto T, Ikebe T, Jingushi S, Hirata M, Koga T Basic fibroblast growth factor inhibits osteoclast-like cell formation. J Cell Physiol 1996 168:395-402 PubMed ID: 8707875 DOI: 10.1002/(SICI)1097-4652(199608)168:2<395::AID-JCP18>3.0.CO;2-2

17997 Clohisy DR, Ogilvie CM, Carpenter RJ, Ramnaraine ML. Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts J Orthop Res 1996 14(1):2-6 PubMed ID: 8618161 DOI: 10.1002/jor.1100140103

4868 Romas E, Udagawa N, Zhou H, Tamura T, Saito M, Taga T, Hilton DJ, Suda T, Ng KW, Martin TJ. The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J Exp Med 1996 183(6):2581-91 PubMed ID: 8676079 DOI: 10.1084/jem.183.6.2581

3926 Jimi E, Nakamura I, Amano H, Taguchi Y, Tsurukai T, Tamura M, Takahashi N, Suda T. Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology. 1996 137(8):2187-90 PubMed ID: 8754795 DOI: 10.1210/endo.137.8.8754795

3927 Yamaguchi 1, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, Rosen V, Yoshiki S. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun 1996 220(2):366-71 PubMed ID: 8645311 DOI: 10.1006/bbrc.1996.0411

17218 Fujikawa Y, Quinn JM, Sabokbar A, McGee JO, Athanasou NA. The human osteoclast precursor circulates in the monocyte fraction Endocrinology 1996 137(9):4058-60 PubMed ID: 8756585 DOI: 10.1210/endo.137.9.8756585

2064 Jimi E, Shuto T, Koga T Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells. Endocrinology 1995 136:808-11 PubMed ID: 7835314 DOI: 10.1210/endo.136.2.7835314

17981 Perkins SL, Kling SJ. Local concentrations of macrophage colony-stimulating factor mediate osteoclastic differentiation Am J Physiol 1995 269(6 Pt 1):E1024-30 PubMed ID: 8572192 DOI: 10.1152/ajpendo.1995.269.6.E1024

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17928 Lacey DL, Erdmann JM, Tan HL. Interleukin 4 increases type 5 acid phosphatase mRNA expression in murine bone marrow macrophages J Cell Biochem 1994 54(3):365-71 PubMed ID: 8200916 DOI: 10.1002/jcb.240540312

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1513 Flanagan, A M, Horton, M A, Dorey, E L, Collins, D A, Evely, R S, Moseley, J M, Firkin, F C, Chambers, T J, Helfrich, M H, Martin, T J An assessment of the ability of human bone marrow cultures to generate osteoclasts. Int J Exp Pathol 1992 73:387-401 PubMed ID: 1320395

1512 Athanasou, N A, Quinn, J M Human tumour-associated macrophages are capable of bone resorption. Br J Cancer 1992 65:523-6 PubMed ID: 1562461 DOI: 10.1038/bjc.1992.108

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17894 Quinn JM, Athanasou NA. Tumour infiltrating macrophages are capable of bone resorption J Cell Sci 1992 101 ( Pt 3):681-6 PubMed ID: 1522150 DOI: 10.1242/jcs.101.3.681

17895 Collins DA, Chambers TJ. Prostaglandin E2 promotes osteoclast formation in murine hematopoietic cultures through an action on hematopoietic cells J Bone Miner Res 1992 7(5):555-61 PubMed ID: 1615762 DOI: 10.1002/jbmr.5650070512

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10334 J Quinn, C Joyner, J T Triffitt, N A Athanasou Polymethylmethacrylate-induced Inflammatory Macrophages Resorb Bone J Bone Joint Surg Br 1992 74(5):652-8 PubMed ID: 1527108 DOI: 10.1302/0301-620X.74B5.1527108

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1330 Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin, T J, Suda T Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A 1990 87:7260-4 PubMed ID: 2169622 DOI: 10.1073/pnas.87.18.7260

1327 Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin, T J, Suda T The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 1989 125:1805-13 PubMed ID: 2676473 DOI: 10.1210/endo-125-4-1805