| 利用者成果(英) |
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19838
Naoi H, Suzuki Y, Miyagi A, Horiguchi R, Aono Y, Inoue Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Mii S, Ichihara M, Takahashi M, Suda T.
CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling
J Immunol
2024
Feb 9:ji2300285
PubMed ID: 38334455
DOI: 10.4049/jimmunol.2300285
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21542
Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A.
RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality.
J Am Chem Soc
2024
PubMed ID: 38170469
DOI: 10.1021/jacs.3c09524
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21615
Shimura T, Sunaga K, Yamazaki M, Honoka N, Sasatani M, Kamiya K, Ushiyama A.
Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response.
Int J Radiat Biol
2024
1-11
PubMed ID: 38166485
DOI: 10.1080/09553002.2023.2295297
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21980
Wajima T, Sugawara T, Tanaka E, Uchiya K-i.
Molecular characterization of a novel putative pathogen, Streptococcus nakanoensis sp. nov., isolated from sputum culture.
Microbiol Spectr
2024
PubMed ID: 39269180
DOI: 10.1128/spectrum.01354-24
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20512
Shimura T, Nakashiro C, Fujiwara K, Shiga R, Sasatani M, Kamiya K, Ushiyama A.
Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts.
J Radiat Res
2022
PubMed ID: 34977941
DOI: 10.1093/jrr/rrab122
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20585
Yanagimura N, Takeuchi S, Fukuda K, Arai S, Tanimoto A, Nishiyama A, Ogo N, Takahashi H, Asai A, Watanabe S, Kikuchi T, Yano S.
STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.
NPJ Precis Oncol
2022
6(1):11
PubMed ID: 35228642
DOI: 10.1038/s41698-022-00254-y
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16391
Sakamoto T, Yu Z, Otani Y.
Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells
Anal Chem
2022
Mar 2
PubMed ID: 35234461
DOI: 10.1021/acs.analchem.1c04804
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20770
Ito K, Nishida Y, Hamada S, Shimizu K, Sakai T, Ohkawara B, Alman BA, Enomoto A, Ikuta K, Koike H, Zhang J, Ohno K, Imagama S.
Efficacy of auranofin as an inhibitor of desmoid progression.
Sci Rep
2022
12(1):11918
PubMed ID: 35831372
DOI: 10.1038/s41598-022-15756-9
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20785
Ju N, Hayashi H, Shimamura M, Baba S, Yoshida S, Morishita R, Rakugi H, Nakagami H.
Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice.
Sci Rep
2022
12(1):12474
PubMed ID: 35864207
DOI: 10.1038/s41598-022-16843-7
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20843
Shimura T, Zaharieva E, Sasatani M, Kawai H, Kamiya K, Ushiyama A.
ACTIVATION OF HUMAN FIBROBLASTS BY CHRONIC RADIATION RATHER THAN ACUTE RADIATION.
Radiat Prot Dosimetry
2022
198(13-15):1098-1103
PubMed ID: 36083750
DOI: 10.1093/rpd/ncac065
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20934
Shimura T, Totani R, Ogasawara H, Inomata K, Sasatani M, Kamiya K, Ushiyama A.
Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation.
Int J Radiat Biol
2022
1-10
PubMed ID: 36383181
DOI: 10.1080/09553002.2023.2142980
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17329
Yap JMG, Ueda T, Kanemitsu Y, Takeda N, Fukumitsu K, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Oguri T, Ugawa S, Niimi A.
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release
Front Immunol
2022
13:921728
PubMed ID: 35941890
DOI: 10.3389/fimmu.2022.921728
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20050
Yap JMG, Ueda T, Kanemitsu Y, Takeda N, Fukumitsu K, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Oguri T, Ugawa S, Niimi A.
AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.
Respir Res
2021
22(1):51
PubMed ID: 33579280
DOI: 10.1186/s12931-021-01636-9
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20392
Shikata M, Toyooka T, Komaki Y, Ibuki Y.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation.
Chem Res Toxicol
2021
PubMed ID: 34784199
DOI: 10.1021/acs.chemrestox.1c00287
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9839
Tomohito Yoshihara, Yasuhiro Nanri, Satoshi Nunomura, Yukie Yamaguchi, Carol Feghali-Bostwick, Keiichi Ajito, Shoichi Murakami 4, Masaaki Mawatari, Kenji Izuhara
Periostin Plays a Critical Role in the Cell Cycle in Lung Fibroblasts
Respir Res
2020
21(1):38
PubMed ID: 32000779
DOI: 10.1186/s12931-020-1299-0
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12045
Yap JMG, Ueda T, Takeda N, Fukumitsu K, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Kanemitsu Y, Niimi A.
An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts.
Cytokine
2020
PubMed ID: 32050145
DOI: 10.1016/j.cyto.2020.155027
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13016
Sano M, Yada R, Nomura Y, Kusukawa T, Ando H, Matsumoto K, Wada K, Tanaka T, Ohara H, Aso Y.
Microbial Screening Based on the Mizoroki-Heck Reaction Permits Exploration of Hydroxyhexylitaconic-Acid-Producing Fungi in Soils.
Microorganisms
2020
PubMed ID: 32365722
DOI: 10.3390/microorganisms8050648
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13087
Nakano T, Ohara Y, Fujita H, Ainai A, Yamamura ET, Suzuki T, Hasegawa H, Sone T, Asano K.
Double-Stranded Structure of the Polyinosinic-Polycytidylic Acid Molecule to Elicit TLR3 Signaling and Adjuvant Activity in Murine Intranasal A(H1N1)pdm09 Influenza Vaccination.
DNA Cell Biol
2020
PubMed ID: 32580635
DOI: 10.1089/dna.2019.5324
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13278
Kometani T, Arai T, Chibazakura T.
Increased Expression of NPM1 Suppresses p27Kip1 Function in Cancer Cells.
Cancers (Basel)
2020
PubMed ID: 33050036
DOI: 10.3390/cancers12102886
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13531
Yamamoto Y, Korogi Y, Hirai T, Gotoh S.
A method of generating alveolar organoids using human pluripotent stem cells
Methods Cell Biol
2020
159:115-14
PubMed ID: 32586440
DOI: 10.1016/bs.mcb.2020.02.004
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11423
Fukuda K, Takeuchi S, Arai S, Katayama R, Nanjo S, Tanimoto A, Nishiyama A, Nakagawa T, Taniguchi H, Suzuki T, Yamada T, Nishihara H, Ninomiya H, Ishikawa Y, Baba S, Takeuchi K, Horiike A, Yanagitani N, Nishio M, Yano S.
Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status.
Cancer Res.
2019
PubMed ID: 30737231
DOI: 10.1158/0008-5472.CAN-18-2052
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11587
Shiraishi K, Nakajima T, Shichino S, Deshimaru S, Matsushima K, Ueha S.
In vitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture.
Biochem. Biophys. Res. Commun.
2019
PubMed ID: 31178143
DOI: 10.1016/j.bbrc.2019.05.187
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6901
Terasaki M, Ikuta M, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M.
Dietary Fucoxanthin Induces Anoikis in Colorectal Adenocarcinoma by Suppressing Integrin Signaling in a Murine Colorectal Cancer Model.
J Clin Med
2019
9(1):90
PubMed ID: 31905803
DOI: 10.3390/jcm9010090
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10822
Takashina T, Koyama T, Nohara S, Hasegawa M, Ishiguro A, Iijima K, Lu J, Shimura M, Okamura T, Sakuma T, Yamamoto T, Ishizaka Y.
Identification of a cell-penetrating peptide applicable to a protein-based transcription activator-like effector expression system for cell engineering.
Biomaterials
2018
173:11-21
PubMed ID: 29734017
DOI: 10.1016/j.biomaterials.2018.04.040
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11194
Park AM, Tsunoda I, Yoshie O.
Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.
J. Biol. Chem.
2018
293(41):15815-15826
PubMed ID: 30166342
DOI: 10.1074/jbc.RA118.003310
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4305
Nakano T, Yamamura ET, Fujita H, Sone T, Asano K.
Novel methods for nucleotide length control in double-stranded polyinosinic-polycytidylic acid production using uneven length components.
Biosci. Biotechnol. Biochem.
2018
PubMed ID: 30079840
DOI: 10.1080/09168451.2018.1501264
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7019
Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, Sone N, Nagasaki T, Matsumoto H, Muro S, Ito I, Hirai T, Kohno T, Suzuki Y, Mishima M.
Long-term expansion of alveolar stem cells derived from human iPS cells in organoids.
Nat. Methods
2017
14:1097-1106
PubMed ID: 28967890
DOI: 10.1038/nmeth.4448
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10135
Komiya K, Ohta S, Arima K, Ogawa M, Suzuki S, Mitamura Y, Nunomura S, Nanri Y, Yoshihara T, Kawaguchi A, Kadota JI, Rubin BK, Izuhara K.
Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts.
Respir. Res.
2017
18:37
PubMed ID: 28219384
DOI: 10.1186/s12931-017-0519-8
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10487
Adachi Y, Watanabe K, Kita K, Kitai H, Kotani H, Sato Y, Inase N, Yano S, Ebi H.
Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer.
Carcinogenesis
2017
38:1063-1072
PubMed ID: 28968756
DOI: 10.1093/carcin/bgx091
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5446
Endo S1, Nakata K2, Ohuchida K3, Takesue S1, Nakayama H1, Abe T1, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C5, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Gastroenterology
2017
152(6):1492-1506
PubMed ID: 28126348
DOI: 10.1053/j.gastro.2017.01.010
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14607
Nanjo S, Arai S, Wang W, Takeuchi S, Yamada T, Hata A, Katakami N, Okada Y, Yano S.
MET Copy Number Gain Is Associated with Gefitinib Resistance in Leptomeningeal Carcinomatosis of EGFR-mutant Lung Cancer
Mol Cancer Ther
2017
16(3):506-515
PubMed ID: 28138027
DOI: 10.1158/1535-7163.MCT-16-0522
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12930
Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O.
Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis
PLoS One
2016
11(2):e0148998
PubMed ID: 26859835
DOI: 10.1371/journal.pone.0148998
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10168
Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro Ogura, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa, Tohru Tanaka
5-Aminolevulinic Acid Enhances Cell Death Under Thermal Stress in Certain Cancer Cell Lines
Biosci Biotechnol Biochem
2015
79(3):422-31
PubMed ID: 25346276
DOI: 10.1080/09168451.2014.975186
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4396
Yamada T, Takeuchi S, Kita K, Bando H, Nakamura T, Matsumoto K, Yano S.
Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.
J Thorac Oncol
2012
7(2):272-80
PubMed ID: 22089117
DOI: 10.1097/JTO.0b013e3182398e69
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7848
Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Matsumoto K, Tanaka M.
Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells.
Anticancer Res.
2011
31:1279-87
PubMed ID: 21508376
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10407
Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A.
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
Nat. Immunol.
2011
12:37-44
PubMed ID: 21102435
DOI: 10.1038/ni.1963
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8639
Hirata N, Takahashi M, Yazawa M.
Diphosphorylation of regulatory light chain of myosin IIA is responsible for proper cell spreading.
Biochem. Biophys. Res. Commun.
2009
381:682-7
PubMed ID: 19254691
DOI: 10.1016/j.bbrc.2009.02.121
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8835
Yoshida K, Munakata H.
Connective tissue growth factor binds to fibronectin through the type I repeat modules and enhances the affinity of fibronectin to fibrin.
Biochim. Biophys. Acta
2007
1770:672-80
PubMed ID: 17239539
DOI: 10.1016/j.bbagen.2006.11.010
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3434
Nikawa H, Egusa H, Makihira S, Okamoto T, Kurihara H, Shiba H, Amano H, Murayama T, Yatani H, Hamada T.
An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells.
Mycoses
2006
49:14-7
PubMed ID: 16367812
DOI: 10.1111/j.1439-0507.2005.01176.x
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3202
Ohuchida, Kenoki, Mizumoto, Kazuhiro, Ogura, Yasuhiro, Ishikawa, Nami, Nagai, Eishi, Yamaguchi, Koji, Tanaka, Masao
Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer.
Clin Cancer Res
2005
11:2285-92
PubMed ID: 15788678
DOI: 10.1158/1078-0432.CCR-04-1581
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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2672
Manabe, Tatsuya, Mizumoto, Kazuhiro, Nagai, Eishi, Matsumoto, Kunio, Nakamura, Toshikazu, Nukiwa, Toshihiro, Tanaka, Masao, Matsuda, Takehisa
Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet.
Clin Cancer Res
2003
9:3158-66
PubMed ID: 12912968
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2709
Yagi, Yasuyuki, Sotani, Tomohiro, Nagao, Toshinori, Horio, Tomoyo, Yamamoto, Itaru, Gohda, Eiichi
Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibition.
Biochem Pharmacol
2003
66:1797-808
PubMed ID: 14563490
DOI: 10.1016/s0006-2952(03)00547-1
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9427
Yoshida K, Suzuki Y, Honda E, Amemiya K, Nakatani T, Ebina M, Narumi K, Satoh K, Munakata H.
Leucine-rich repeat region of decorin binds to filamin-A.
Biochimie
2002
84:303-8
PubMed ID: 12106908
DOI: 10.1016/s0300-9084(02)01391-3
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3786
Ogawa-Goto K, Irie S, Omori A, Miura Y, Katano H, Hasegawa H, Kurata T, Sata T, Arao Y.
An endoplasmic reticulum protein, p180, is highly expressed in human cytomegalovirus-permissive cells and interacts with the tegument protein encoded by UL48.
J Virol
2002
76(5):2350-62
PubMed ID: 11836413
DOI: 10.1128/jvi.76.5.2350-2362.2002
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2631
Saitoh T, Takemura S, Ueda K, Hosoya H, Nagayama M, Haga H, Kawabata K, Yamagishi A, Takahashi M
Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts.
FEBS Lett
2001
509:365-9
PubMed ID: 11749957
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2531
Masters JR, Thomson JA, Daly-Burns B, Reid YA, Dirks WG, Packer P, Toji LH, Ohno T, Tanabe H, Arlett CF, Kelland LR, Harrison M, Virmani A, Ward TH, Ayres KL, Debenham PG.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc Natl Acad Sci U S A.
2001
98(14):8012-7
PubMed ID: 11416159
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2070
Shindoh M, Higashino F, Kaya M, Yasuda M, Funaoka K, Hanzawa M, Hida K, Kohgo T, Amemiya A, Yoshida K, Fujinaga K
Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.
Am J Pathol
1996
148:693-700
PubMed ID: 8774124
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1808
Matsunaga T, Gohda E, Takebe T, Wu, Y L, Iwao M, Kataoka H, Yamamoto I
Expression of hepatocyte growth factor is up-regulated through activation of a cAMP-mediated pathway.
Exp Cell Res
1994
210:326-35
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10096
Zhao FQ, Glimm DR, Kennelly JJ.
Distribution of mammalian facilitative glucose transporter messenger RNA in bovine tissues.
Int. J. Biochem.
1993
25:1897-903
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1809
Gohda E, Matsunaga T, Kataoka H, Yamamoto I
TGF-beta is a potent inhibitor of hepatocyte growth factor secretion by human fibroblasts.
Cell Biol Int Rep
1992
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