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22096
Watanabe D, Hiroshima M, Yasui M, Ueda M.
Single molecule tracking based drug screening.
Nat Commun
2024
15(1):8975
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19545
Chinsuwan T, Hirabayashi K, Mishima S, Hasegawa A, Tanaka M, Mochizuki H, Shimoi A, Murakami T, Yagyu S, Shimizu K, Nakazawa Y.
Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers
Mol Ther Oncolytics
2023
31:100728
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21008
Zhang A, Abdellatef SA, Nakanishi J.
Mechanistic investigation into selective cytotoxic activities of gold nanoparticles functionalized with epidermal growth factor variants.
Anal Sci
2023
PubMed ID: 36639559
DOI: 10.1007/s44211-022-00256-7
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21088
Tsuruyama T.
Kullback-Leibler Divergence of an Open-Queuing Network of a Cell-Signal-Transduction Cascade.
Entropy (Basel)
2023
25(2)
PubMed ID: 36832692
DOI: 10.3390/e25020326
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16738
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama
Critical Residues of Clostridium perfringens Delta-Toxin for Oligomerization and Receptor Binding
BPB Reports
2022
5:66-69
DOI: 10.1248/bpbreports.5.3_66
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20774
Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.
Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.
Nat Commun
2022
13(1):4063
PubMed ID: 35831322
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20881
Kiso-Farnè K, Tsuruyama T.
Epidermal growth factor receptor cascade prioritizes the maximization of signal transduction.
Sci Rep
2022
12(1):16950
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20954
Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M.
ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.
Nat Commun
2022
13(1):7476
PubMed ID: 36463234
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20965
Morisaka H, Takaishi M, Akira S, Sano S.
Keratinocyte Regnase-1, a down-regulator of skin inflammation, contributes to protection against tumor promotion by limiting COX-2 expression.
J Invest Dermatol
2022
PubMed ID: 36470473
DOI: 10.1016/j.jid.2022.11.007
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13912
Yamamoto S, Nakanishi J.
Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle
Anal Sci
2021
37(5):741-745
PubMed ID: 33390415
DOI: 10.2116/analsci.20SCP16
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20118
Abiko Y, Kurosawa K, Yamakawa H, Kumagai Y.
Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells.
J Toxicol Sci
2021
46(4),177-185
PubMed ID: 33814511
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14839
Pascarelli S, Merzhakupova D, Uechi GI, Laurino P.
Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling
J Biol Chem
2021
297(1):100872
PubMed ID: 34126069
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20427
Tsumagari K, Chang CH, Ishihama Y.
A protocol for analyzing the protein terminome of human cancer cell line culture supernatants.
STAR Protoc
2021
2(3):100682
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20442
Zhang A, Nakanishi J.
Improved anti-cancer effect of epidermal growth factor-gold nanoparticle conjugates by protein orientation through site-specific mutagenesis.
Sci Technol Adv Mater
2021
22(1):616-626
PubMed ID: 34512175
DOI: 10.1080/14686996.2021.1944783
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13433
Setsuko Tsuboi, Takashi Jin
Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours
RSC Adv
2020
10(47):28171-28179
PubMed ID: 35519107
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13442
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara
The Inhibitory Effect of Cholera Toxin B Subunit on Clostridium Perfringens Iota-Toxin-Induced Cytotoxicity
BPB Reports
2020
DOI: 10.1248/bpbreports.3.4_146
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13557
Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y.
Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B
J Toxicol Sci
2020
45(6):349-36
PubMed ID: 32493877
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11730
Kobayashi Y, Iwakura Y, Sotoyama H, Kitayama E, Takei N, Someya T, Nawa H.
Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases.
Transl Psychiatry
2019
PubMed ID: 31371697
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9926
Setsuko Tsuboia and Takashi Jin
BRET based dual-colour (visible/near-infrared) molecular imaging using a quantum dot/EGFP–luciferase conjugate
RSC Adv
2019
9:34964-34971
PubMed ID: 35530680
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12371
Abiko Y, Nakai Y, Luong NC, Bianco CL, Fukuto JM, Kumagai Y.
Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na 2 S 2: Evidence for One-Electron Reduction Reaction
Chem Res Toxicol
2019
32(4):551-556
PubMed ID: 30719914
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19254
Kariya Y, Oyama M, Hashimoto Y, Gu J, Kariya Y.
β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3-N-Glycan Complex.
Mol Cancer Res
2018
16(6):1024-1034
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11076
Toyama K, Nomura W, Kobayakawa T, Tamamura H.
Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
Bioconjug. Chem.
2018
29(6):2050-2057
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Osaki T, Nakanishi T, Aoki M, Omizu T, Nishiura D, Kitamura M.
Soluble Expression in Escherichia coli of a Single-Domain Antibody-Tumor Necrosis Factor α Fusion Protein Specific for Epidermal Growth Factor Receptor.
Monoclon Antib Immunodiagn Immunother
2018
PubMed ID: 29474158
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4467
Toyama K, Kobayakawa T, Nomura W, Tamamura H.
Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
Chem. Pharm. Bull.
2018
66(11):1083-1089
PubMed ID: 30381661
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6021
Hasegawa G, Akatsuka K, Nakashima Y, Yokoe Y, Higo N, Shimonaka M.
Tamoxifen inhibits the proliferation of non‑melanoma skin cancer cells by increasing intracellular calcium concentration.
Int J Oncol
2018
53(5):2157-2166
PubMed ID: 30226592
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Sudo K, Niikura K, Iwaki K, Kohyama S, Fujiwara K, Doi N.
Human-derived fusogenic peptides for the intracellular delivery of proteins.
J Control Release
2017
255:1-11
PubMed ID: 28385674
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14029
Shibuya Y, Haga N, Asano R, Nakazawa H, Hattori T, Takeda D, Sugiyama A, Kurotani R, Kumagai I, Umetsu M, Makabe K.
Generation of camelid VHH bispecific constructs via in-cell intein-mediated protein trans-splicing
Protein Eng Des Sel
2017
30(1):15-21
PubMed ID: 27881685
DOI: 10.1093/protein/gzw057
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9117
Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama
Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis
PLoS One
2016
11 (1), e0147957
PubMed ID: 26807591
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12681
Toyama K, Mizuguchi T, Nomura W, Tamamura H.
Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization
Bioorg Med Chem
2016
24(16):3406-12
PubMed ID: 27283787
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Niikura K, Horisawa K, Doi N.
Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation
J Biochem
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PubMed ID: 26338729
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Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor
Int J Cancer
2016
139(3):700-11
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Hara-Chikuma M, Watanabe S, Satooka H.
Involvement of aquaporin-3 in epidermal growth factor receptor signaling via hydrogen peroxide transport in cancer cells
Biochem Biophys Res Commun
2016
471(4):603-9
PubMed ID: 26896765
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14093
Batzaya Byambaa, Tomohiro Konno, Kazuhiko Ishihara
Photoinduced detachment of cells adhered on 2-methacryloyloxyethyl phosphorylcholine polymer with cell binding molecule through photocleavable linkage
Reactive and Functional Polymers
2016
104:30-37
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14188
Daisuke Takahashi, Takashi Nagao, Shota Sotokawa, Kazunobu Toshima
Target-selective photo-degradation of a sialyl Lewis a (sLea) conjugate and photo-cytotoxicity against sLea positive cancer cells using an anthraquinone-antibody hybrid
MedChemComm
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Osaki T, Wang CX, Tachibana T, Azuma M, Kitamura M, Nakanishi T.
Generation and Characterization of Rat Monoclonal Antibodies Against Epidermal Growth Factor Receptor
Monoclon Antib Immunodiagn Immunother
2015
34(6):418-22
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14980
Abiko Y, Luong NC, Kumagai Y.
A Biotin-PEAC5-maleimide labeling assay to detect electrophiles
J Toxicol Sci
2015
40(3):405-11
PubMed ID: 25972200
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15531
Osaki T, Fujisawa S, Kitaguchi M, Kitamura M, Nakanishi T.
Development of a bispecific antibody tetramerized through hetero-associating peptides
FEBS J
2015
282(22):4389-401
PubMed ID: 26337767
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15865
Yutaka Hitomi, Toshiyuki Takeyasu, Masahito Kodera
Development of Green-Emitting Iron Complex-Based Fluorescent Probes for Intracellular Hydrogen Peroxide Imaging
Bulletin of the Chemical Society of Japan
2014
87:819-824
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7928
Shoji Y, Miyamoto M, Ishikawa K, Yoshioka T, Mishra R, Ichinokawa K, Matsumura Y, Itoh T, Shinohara T, Hirano S, Kondo S.
The CD40-CD154 interaction would correlate with proliferation and immune escape in pancreatic ductal adenocarcinoma.
J Surg Oncol
2011
103:230-8
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7956
Uchino T, Ikarashi Y, Nishimura T.
Effects of coating materials and size of titanium dioxide particles on their cytotoxicity and penetration into the cellular membrane.
J Toxicol Sci
2011
36:95-100
PubMed ID: 21297346
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18580
Iijima M, Matsuzaki T, Yoshimoto N, Niimi T, Tanizawa K, Kuroda S.
Fluorophore-labeled nanocapsules displaying IgG Fc-binding domains for the simultaneous detection of multiple antigens
Biomaterials
2011
32(34):9011-20
PubMed ID: 21864900
DOI: 10.1016/j.biomaterials.2011.08.012
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19029
Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y.
LRRN4 and UPK3B are markers of primary mesothelial cells
PLoS One
2011
6(10):e25391
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5355
Kishor Mazumder et al
Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines
Phytochemistry Letters
2011
4:287-291
DOI: 10.1016/j.phytol.2011.04.019
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9083
Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai
Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis
Infect Immun
2011
79 (11), 4353-60
PubMed ID: 21911469
DOI: 10.1128/IAI.05677-11
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13818
Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura
Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene
Journal of Electromagnetic Analysis and Applications
2010
2:382-394
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18312
Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431
Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431
Biochem Biophys Res Commun
2008
373(1):36-41
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Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S.
Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction.
Endocr. Relat. Cancer
2008
15:451-63
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18668
Hirano T, Morii H, Nakazawa K, Murakami D, Yamashita A, Asahi J, Orimo H, Tamae K, Tokura Y.
Enhancement of adipogenesis induction by conditioned media obtained from cancer cells
Cancer Lett
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Involvement of EGFR in the response of squamous cell carcinoma of the head and neck cell lines to gefitinib
Oncol Rep
2008
19(1):65-71
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18869
Hong J, Yokomakura A, Nakano Y, Ishihara K, Kaneda M, Onodera M, Nakahama K, Morita I, Niikura K, Ahn JW, Zee O, Ohuchi K.
Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells
FEBS Lett
2006
580(11):2723-30
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17939
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Anti-angiogenic effect of an insertional fusion protein of human basic fibroblast growth factor and ribonuclease-1
Protein Eng Des Sel
2005
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Tsuji T, Kawada Y, Kai-Murozono M, Komatsu S, Han SA, Takeuchi K, Mizushima H, Miyazaki K, Irimura T.
Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3).
Clin Exp Metastasis
2002
19(2):127-34
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Tanimura A, Tojyo Y, Turner RJ.
Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins
J Biol Chem
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Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts.
Br J Cancer
1999
80(8):1137-43
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Takenouchi T, Kadosaka M, Shin SY, Munekata E.
Biological actions of the epidermal growth factors-like domain peptides of mouse schwannoma-derived growth factor and human amphiregulin
J Pept Res
1999
53(2):120-5
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Possible regulation of epidermal growth factor-receptor tyrosine autophosphorylation by calcium and G proteins in chemically permeabilized rat UMR106 cells
Arch Oral Biol
1999
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Ishida A, Sasaguri T, Miwa Y, Kosaka C, Taba Y, Abumiya T.
Tumor suppressor p53 but not cGMP mediates NO-induced expression of p21(Waf1/Cip1/Sdi1) in vascular smooth muscle cells
Mol Pharmacol
1999
56(5):938-46
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17247
Yasuyuki Suzuki, Yasuhiro Ozawa, Kazuo Murakami, Hitoshi Miyazaki
Inhibition of epidermal growth factor-induced stat1 activation by lysophosphatidic acid is mediated by pertussis toxin-sensitive g proteins and tyrosine phosphatase in human epidermoid carcinoma A431 cells
IUBMB Life
1998
44:979-987
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18115
Suzuki Y, Ozawa Y, Murakami K, Miyazaki H.
Lysophosphatidic acid inhibits epidermal-growth-factor-induced Stat1 signaling in human epidermoid carcinoma A431 cells
Biochem Biophys Res Commun
1997
240(3):856-61
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Sato T, Nakajima H, Fujio K, Mori Y.
Enhancement of prostaglandin E2 production by epidermal growth factor requires the coordinate activation of cytosolic phospholipase A2 and cyclooxygenase 2 in human squamous carcinoma A431 cells.
Prostaglandins
1997
53(5):355-69
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2069
Okada N, Fushimi M, Nagata Y, Fukunaga T, Tsutsumi Y, Nakagawa S, Mayumi T.
Evaluation of angiogenic inhibitors with an in vivo quantitative angiogenesis method using agarose microencapsulation and mouse hemoglobin enzyme-linked immunosorbent assay.
Jpn J Cancer Res
1996
87(9):952-7
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Osada H, Kono T, Miwa K, Yamada C.
Phorbol-ester-stimulated human lymphoid cell lines produce a plasminogen activator modulator inducing cell-bound urokinase-type plasminogen activator in malignant tumor cell lines
Int J Cancer
1996
65(2):178-85
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17933
Takenouchi T, Kadosaka M, Shin SY, Munekata E.
Chemical synthesis and biological activities of the EGF-like domain of mouse schwannoma-derived growth factor (SDGF)
Int J Pept Protein Res
1995
46(5):391-6
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Synthesis and biological activity of N-terminal-truncated derivatives of human epidermal growth factor (h-EGF)
Peptides
1995
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Okada N, Fushimi M, Nagata Y, Fukunaga T, Tsutsumi Y, Nakagawa S, Mayumi T.
A quantative in vivo method of analyzing human tumor-induced angiogenesis in mice using agarose microencapsulation and hemoglobin enzyme-linked immunosorbent assay.
Jpn J Cancer Res
1995
86(12):1182-8
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Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines.
Cancer Lett
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82(1):27-32
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APC gene messenger RNA: novel isoforms that lack exon 7
Cancer Res
1993
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Hirano Y, Okuno M, Hayashi T, Goto K, Nakajima A.
Cell-attachment activities of surface immobilized oligopeptides RGD, RGDS, RGDV, RGDT, and YIGSR toward five cell lines
J Biomater Sci Polym Ed
1993
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Yoshiaki Hirano, Motoya Okuno, Toshio Hayashi, Akio Nakajima
Liquid-Phase Synthesis and Cell Attachment Activity of Bioactive Pentapeptide YIGSR.
Polymer Journal
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